Compounds > tacrine

tacrine and ferulic acid

tacrine has been researched along with ferulic acid in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.67)29.6817
2010's11 (73.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Decker, M; Fang, L; Heilmann, J; Kraus, B; Lehmann, J; Zhang, Y1
Bautista-Aguilera, OM; Benchekroun, M; Buendía, I; Egea, J; Ismaili, L; Janockova, J; Jimeno, ML; Jun, D; León, R; Marco-Contelles, J; Michalska, P; Ouari, O; Refouvelet, B; Romero, A; Sepsova, V; Soukup, O1
Bonet, A; Chabchoub, F; Dgachi, Y; García-Iriepa, C; Godyń, J; Iriepa, I; Ismaili, L; Janockova, J; Luzet, V; Malawska, B; Marco-Contelles, J; Martin, H; Moraleda, I; Panek, D; Richert, L; Sokolov, O; Soukup, O1
Andrisano, V; Apperley, KYP; Bartolini, M; Baschieri, A; Basso, M; Chen, HH; De Simone, A; Guardigni, M; Keillor, JW; Kobrlova, T; Milelli, A; Montanari, S; Soukup, O; Valgimigli, L1
Fang, L; Gou, S; Liu, Z; Xia, S; Zhang, B1
Kumar, S; Mishra, S; Modi, G; Rai, H; Singh, G; Singh, GK; Singh, YP; Srikrishna, S1
İmamoğlu, R; Kısa, D; Koç, E1
Appenroth, D; Decker, M; Fang, L; Fleck, C; Lehmann, J; Lupp, A1
Appenroth, D; Decker, M; Fang, L; Fleck, C; Lehmann, J; Schott, Y1
Cui, W; Han, R; Han, Y; Hu, S; Li, W; Mak, S; Pi, R; Ye, M; Zhang, H1
Chao, X; Chen, X; Cheng, Z; Duan, X; Han, Y; Li, W; Liu, M; Liu, P; Mao, X; Mei, Z; Pi, R; Ye, M1
Andrisano, V; Bartolini, M; Benchekroun, M; Bolognesi, ML; de Andrés, L; Decker, M; Egea, J; Gharbi, T; Herrera-Arozamena, C; Ismaili, L; Jimeno, ML; López, MG; Luzet, V; Marco-Contelles, J; Monti, B; Pudlo, M; Refouvelet, B; Rodríguez-Franco, MI; Romero, A; Soriano, E; Wehle, S1
Chen, Z; Chu, J; Digiacomo, M; Han, Y; Lapucci, A; Macchia, M; Pi, R; Rapposelli, S; Wang, S; Yang, X1
Fu, Y; Han, L; Huang, X; Lei, H; Leng, Q; Li, X; Mu, Y; Qu, X; Wang, P; Wang, Z1
Bian, Y; Chen, Y; Li, Q; Lin, H; Mo, J; Pei, Y; Sun, H; Yang, H; Zhu, J1

Reviews

1 review(s) available for tacrine and ferulic acid

ArticleYear
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Apr-05, Volume: 215

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Coumaric Acids; Humans; Neuroprotective Agents; Oxidative Stress; Protein Multimerization

2021

Other Studies

14 other study(ies) available for tacrine and ferulic acid

ArticleYear
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
    Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9

    Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromans; Coumaric Acids; Drug Design; Humans; Models, Chemical; Reactive Oxygen Species; Structure-Activity Relationship; Tacrine

2008
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
    Journal of medicinal chemistry, 2016, 11-10, Volume: 59, Issue:21

    Topics: Alzheimer Disease; Antioxidants; Cell Death; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Coumaric Acids; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Melatonin; Molecular Structure; NF-E2-Related Factor 2; Structure-Activity Relationship

2016
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.
    European journal of medicinal chemistry, 2017, Jan-27, Volume: 126

    Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Antioxidants; Blood-Brain Barrier; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; GPI-Linked Proteins; Humans

2017
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: Alzheimer Disease; Animals; Cinnamates; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycogen Synthase Kinase 3 beta; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2017
ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker.
    European journal of medicinal chemistry, 2021, Feb-15, Volume: 212

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Boronic Acids; Cells, Cultured; Cholinesterase Inhibitors; Cytokines; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lipopolysaccharides; Mice; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Prodrugs; Reactive Oxygen Species; Structure-Activity Relationship; Tacrine

2021
Polyphenolic compounds: Synthesis, assessment of antimicrobial effect and enzymes inhibition against important medicinal enzymes with computational details.
    Bioorganic & medicinal chemistry letters, 2022, 06-01, Volume: 65

    Topics: Acetylcholinesterase; Anti-Infective Agents; Antioxidants; Cholinesterase Inhibitors; Cholinesterases; Humans; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Structure-Activity Relationship

2022
Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison to tacrine.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:5

    Topics: Alzheimer Disease; Animals; Chemical and Drug Induced Liver Injury; Coumaric Acids; Cytochrome P-450 Enzyme System; Female; Glutathione; Heme Oxygenase-1; Lipid Peroxidation; Liver; Liver Glycogen; Nitric Oxide Donors; Nootropic Agents; Oxidative Stress; Rats; Rats, Wistar; Tacrine

2010
Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:6

    Topics: Animals; Carbolines; Cognition; Cognition Disorders; Coumaric Acids; Female; Maze Learning; Rats; Rats, Wistar; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine; Tacrine

2010
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.
    Neurochemistry international, 2011, Volume: 59, Issue:7

    Topics: Animals; Apoptosis; Coumaric Acids; Dimerization; Enzyme Activation; Oxidopamine; PC12 Cells; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Tacrine

2011
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Coumaric Acids; Dimerization; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Models, Chemical; PC12 Cells; Peptides; Reactive Oxygen Species; Superoxide Dismutase; Tacrine

2012
Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
    ChemMedChem, 2015, Volume: 10, Issue:3

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Discovery; Hep G2 Cells; Humans; Models, Molecular; Neuroprotective Agents; Rats, Wistar; Tacrine

2015
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
    Bioorganic & medicinal chemistry letters, 2015, Feb-15, Volume: 25, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Caffeic Acids; Cell Line; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Humans; Models, Molecular; Structure-Activity Relationship; Tacrine; Thioctic Acid

2015
Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer's Disease.
    Molecules (Basel, Switzerland), 2016, Oct-11, Volume: 21, Issue:10

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Line; Cell Survival; Chelating Agents; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tacrine

2016
Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Aggregates; Scopolamine; Structure-Activity Relationship; Tacrine

2018