tacrine has been researched along with donepezil in 268 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 41 (15.30) | 18.2507 |
| 2000's | 93 (34.70) | 29.6817 |
| 2010's | 98 (36.57) | 24.3611 |
| 2020's | 36 (13.43) | 2.80 |
| Authors | Studies |
|---|---|
| Cardozo, MG; Hopfinger, AJ; Iimura, Y; Sugimoto, H; Yamanishi, Y | 1 |
| Bigg, DC; Briley, M; Calmel, F; Carilla, E; Vidaluc, JL | 1 |
| Chapin, D; Chen, YL; Hubbard, S; Ives, JL; Jones, SB; Jung, S; Liston, DR; Mahar, M; Nagel, AA; Vincent, LA | 1 |
| Biggers, CK; Blake, JF; Butler, TW; Chapin, DS; Chen, YL; Ives, JL; Jones, SB; Liston, DR; Nagel, AA; Villalobos, A | 1 |
| Chen, Y; Collantes, ER; Tong, W; Welsh, WJ | 1 |
| Bourguignon, JJ; Chayer, S; Contreras, JM; Rival, YM; Wermuth, CG | 1 |
| Contreras, JM; Parrot, I; Rival, YM; Sippl, W; Wermuth, CG | 1 |
| Andreani, A; Cavalli, A; Granaiola, M; Guardigli, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Recanatini, M; Roda, A | 1 |
| Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X | 1 |
| Campiani, G; Catalanotti, B; Chiasserini, L; Fattorusso, C; Gaeta, A; McKissic, D; Novellino, E; Pellerano, C; Savini, L; Saxena, A | 1 |
| Andrisano, V; Banzi, R; Bartolini, M; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V | 1 |
| Alley, GM; Brossi, A; Deschamps, JR; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, D; Yu, QS; Zhan, M | 1 |
| Agnusdei, M; Belinskaya, T; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fedorko, JM; Gaeta, A; Gemma, S; Greig, NH; Holloway, HW; Nacci, V; Novellino, E; Persico, M; Savini, L; Saxena, A | 1 |
| Alonso, D; Bidon-Chanal, A; Castro, A; Del Monte, M; Dorronsoro, I; García-Palomero, E; Luque, FJ; Martínez, A; Medina, M; Muñoz, P; Orozco, M; Rubio, L | 1 |
| Andrisano, V; Bartolini, M; Bidon-Chanal, A; de Austria, C; del Monte-Millán, M; Dorronsoro, I; García-Palomero, E; Luque, FJ; Martínez, A; Medina, M; Muñoz-Ruiz, P; Orozco, M; Rubio, L; Usán, P; Valenzuela, R | 1 |
| Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS | 1 |
| Andreani, A; Burnelli, S; Granaiola, M; Guardigli, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Rizzoli, M; Roda, A; Varoli, L | 1 |
| Chae, BS; Eun, JS; Kim, DK; Kim, KH; Kwon, YE; Lee, SK; Leem, JY; No, KT; Park, JY; Shin, JH; Shin, TY; Yang, JH | 1 |
| Andrisano, V; Banzi, R; Bartolini, M; Bergamini, C; Bolognesi, ML; Cattaneo, A; Cavalli, A; Fato, R; Hrelia, P; Lenaz, G; Melchiorre, C; Minarini, A; Recanatini, M; Rosini, M; Tarozzi, A; Tumiatti, V | 1 |
| Bolognesi, ML; Cavalli, A; Melchiorre, C; Minarini, A; Recanatini, M; Rosini, M; Tumiatti, V | 1 |
| Andrisano, V; Badia, A; Bartolini, M; Bidon-Chanal, A; Camins, A; Camps, P; Clos, MV; Estelrich, J; Formosa, X; Galdeano, C; Gómez, T; Lizondo, M; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Pallàs, M; Scarpellini, M; Viayna, E | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Lv, W; Xue, Y | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M | 1 |
| Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Al-Rashid, ZF; Hsung, RP | 1 |
| Campos, JM; Carotti, A; Catto, M; Conejo-García, A; Espinosa, A; Gallo, MA; Leonetti, F; Nicolotti, O; Núñez, Mdel C; Pisani, L | 1 |
| Boido, V; Carotti, A; Catto, M; Giangreco, I; Nicolotti, O; Novelli, F; Pisani, L; Sparatore, A; Sparatore, F; Tasso, B; Tonelli, M | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Bolea, I; Chioua, M; de Los Ríos, C; Juárez-Jiménez, J; Luque, FJ; Marco-Contelles, J; Pouplana, R; Samadi, A; Unzeta, M | 1 |
| Andrisano, V; Bartolini, M; Bolea, I; Chioua, M; de los Ríos, C; Gálvez, E; Iriepa, I; Marco-Contelles, J; Moraleda, I; Samadi, A; Unzeta, M; Valderas, C | 1 |
| Huang, L; Li, XS; Mao, F; Meng, FC; Qin, F; Shan, WJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bazureau, JP; Burgy, G; Carreaux, F; Cochet, C; Delhommel, F; Durieu, E; Elkins, JM; Filippakopoulos, P; Knapp, S; Lo, DC; Meijer, L; Oberholzer, AE; Pearl, LH; Schmid, RS; Soundararajan, M; Tahtouh, T | 1 |
| Carotti, A; Catto, M; Cellamare, S; Leonetti, F; Nicolotti, O; Pesce, P; Pisani, L; Stefanachi, A | 1 |
| Chandrashankra, O; Hu, Y; Ip, FC; Ip, NY; Zhang, J | 1 |
| Mohamed, T; Osman, W; Rao, PP; Tin, G | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, J; Chen, X; Huang, L; Li, X; Sun, Y | 1 |
| Huang, L; Li, X; Liu, A; Lu, C; Luo, HB; Luo, Z; Sheng, J; Sun, Y; Yan, J | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Huang, L; Li, J; Li, X; Liang, L; Luo, Z; Pang, Y; Sheng, J | 1 |
| Ismaïli, L; Iutzeler, A; Luzet, V; Pudlo, M; Refouvelet, B; Tomassoli, I | 1 |
| Huang, L; Li, X; Meng, F; Miao, H; Sun, Y | 1 |
| Bajda, M; Brus, B; Gobec, S; Guzior, N; Kos, J; Kurpiewska, K; Lewiński, K; Malawska, B; Pišlar, A; Skrok, M | 1 |
| Bajda, M; Brus, B; Gobec, S; Guzior, N; Malawska, B; Rakoczy, J | 1 |
| Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K | 1 |
| Asadipour, A; Emami, S; Foroumadi, A; Gouranourimi, A; Hekmat, S; Moghadam, FH; Moradi, A; Nadri, H; Pourshojaei, Y; Rahmani-Nezhad, S; Shafiee, A | 1 |
| Giridhar, R; Kanhed, AM; Machhi, J; Parikh, ZS; Pillai, PP; Sinha, A; Tripathi, A; Yadav, MR | 1 |
| Amooru, GD; Ampasala, DR; Darla, MM; Devineni, SR; Eadlapalli, S; Kotapati, KV; Palaka, BK; Penumala, M; Shaik, JB; Vadde, R | 1 |
| Bachurin, SO; Boltneva, NP; Lushchekina, SV; Makhaeva, GF; Proshin, AN; Richardson, RJ; Serebryakova, OG; Serkov, IV; Stupina, TS; Terentiev, AA | 1 |
| Jiang, N; Kong, LY; Lan, JS; Li, F; Wang, J; Wang, X; Wang, ZM; Wu, JJ; Xie, SS | 1 |
| Chimnoi, N; Khunnawutmanotham, N; Saparpakorn, P; Techasakul, S | 1 |
| Amjad, MW; Bukhari, SN; Hussain, MA; Hussain, Z; Jantan, I; Qin, HL; Sher, M; Zha, GF; Zhang, CP | 1 |
| Hoda, N; Jameel, E; Jayaram, B; Kumar, J; Manral, A; Maqbool, M; Saini, V; Shandilya, A; Tiwari, M | 1 |
| Hoda, N; Jameel, E; Jayaram, B; Kumar, J; Maqbool, M; Meena, P; Mobashir, M; Shandilya, A; Singh, A; Tiwari, M | 1 |
| Agrawal, N; Machhi, J; Murumkar, P; Parikh, Z; Pillai, P; Sharma, MK; Shidore, M; Shingala, K; Tripathi, A; Yadav, MR | 1 |
| Beazely, MA; Mohamed, T; Osman, W; Rao, PP; Sit, VM; Vasefi, MS | 1 |
| Aitken, L; Benek, O; Dohnal, V; Dolezal, R; Guest, P; Gunn-Moore, F; Hroch, L; Janockova, J; Kuca, K; Musil, K; Musilek, K; Smith, TK; Soukup, O | 1 |
| Brazzolotto, X; Chan, S; De la Mora, E; Deora, GS; Dighe, SN; Nachon, F; Parat, MO; Ross, BP | 1 |
| Ahmad, W; Amjad, MW; Bukhari, SN; Hussain, MA; Jantan, I; Leng, J; Naeem-Ul-Hassan, M; Qin, HL; Sher, M; Zhu, K | 1 |
| Bajda, M; Jończyk, J; Kieć-Kononowicz, K; Kuder, K; Malawska, B; Moore, C; Panek, D; Szałaj, N; Więckowska, A; Łażewska, D | 1 |
| Kong, LY; Li, F; Li, XM; Wang, J; Wang, XB; Wang, ZM; Wu, JJ | 1 |
| Cai, P; Kong, LY; Liu, QH; Wang, XB; Wang, ZM; Wu, JJ; Xu, DQ; Yang, XL | 1 |
| Bienkowski, P; Bucki, A; Gobec, S; Godyń, J; Głuch-Lutwin, M; Kazek, G; Knez, D; Kołaczkowski, M; Malawska, B; Marcinkowska, M; Mierzejewski, P; Sienkiewicz-Jarosz, H; Siwek, A; Wichur, T; Więckowska, A; Więckowski, K; Zaręba, P | 1 |
| Bajda, M; Gobec, S; Godyń, J; Janockova, J; Jończyk, J; Knez, D; Korabecny, J; Malawska, B; Mika, K; Panek, D; Soukup, O; Wichur, T; Więckowska, A | 1 |
| Foka, GB; Joubert, J; Kapp, E; Malan, SF; Oliver, DW; Repsold, BP | 1 |
| Ilgın, S; Özkay, Y; Sağlık, BN | 1 |
| Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL | 1 |
| Ahmed, W; Hoda, N; Jameel, E; Jayaram, B; Kumar, J; Maqbool, M; Meena, P; Mumtazuddin, S; Tiwari, M | 1 |
| Azzouz, R; Bohn, P; Gembus, V; Levacher, V; Papamicaël, C; Peauger, L; Sopková-de Oliveira Santos, J; Ţînţaş, ML | 1 |
| Asadipour, A; Bukhari, SNA; Emami, S; Firoozpour, L; Foroumadi, A; Golshani, M; Homayouni Moghadam, F; Jafari, M; Jalili-Baleh, L; Khoobi, M; Moradi, A; Nadri, H; Shakibaie, M | 1 |
| Andrisano, V; Apperley, KYP; Bartolini, M; Baschieri, A; Basso, M; Chen, HH; De Simone, A; Guardigni, M; Keillor, JW; Kobrlova, T; Milelli, A; Montanari, S; Soukup, O; Valgimigli, L | 1 |
| Anjum, R; Bernhardt, PV; Hibbs, D; Kalinowski, DS; Lin, HY; Palanimuthu, D; Poon, R; Richardson, DR; Sahni, S | 1 |
| Campillo, NE; Cañada, FJ; Carvalho, I; Castillo, WO; Chierrito, TPC; Jiménez-Barbero, J; Martinez, A; Moreira, NCS; Pedersoli-Mantoani, S; Pérez, C; Requena, C; Roca, C; Sakamoto-Hojo, ET; Sebastian-Perez, V; Takahashi, CS | 1 |
| Alabiso, F; Andrisano, V; Bartolini, M; Bergamini, C; Bortolami, M; Coluccia, A; Costi, R; De Vita, D; Di Santo, R; Fato, R; Pandolfi, F; Scipione, L | 1 |
| Azzouz, R; Gembus, V; Levacher, V; Papamicaël, C; Peauger, L; Sopková-de Oliveira Santos, J; Ţînţaş, ML | 1 |
| Huang, Q; Jiang, N; Li, Q; Liang, N; Liu, J; Xie, SS | 1 |
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Akbarzadeh, T; Amini, M; Bukhari, SNA; Edraki, N; Ghobadian, R; Mahdavi, M; Moradi, A; Nadri, H; Sharifzadeh, M | 1 |
| Brazzolotto, X; Colletier, JP; Coquelle, N; Gobec, S; Jukič, M; Knez, D; Kos, J; Mravljak, J; Nachon, F; Pišlar, A; Sova, M; Žakelj, S | 1 |
| Akbarzadeh, T; Amini, M; Asadi, M; Bukhari, SNA; Ghobadian, R; Khaleghzadeh-Ahangar, H; Mahdavi, M; Moradi, A; Nadri, H; Sharifzadeh, M | 1 |
| Alcaro, S; Bagetta, D; Borges, F; Cagide, F; Oliveira, PJ; Ortuso, F; Pérez, C; Reis, J; Rodríguez-Franco, MI; Teixeira, J; Uriarte, E; Valencia, ME | 1 |
| Kumar, A; Mishra, P; Panda, G | 1 |
| Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| Bolognesi, ML; da Costa Nunes, JL; de Oliveira Miranda, C; de Oliveira, AS; Gandini, A; Gervasoni, S; Jung, M; Kobrlova, T; Massenzio, F; Monti, B; Petralla, S; Rossi, M; Senger, J; Simões Heyn Roth Cardoso, G; Soares Romeiro, LA; Soukup, O; Vistoli, G | 1 |
| Han, J; Ji, L; Li, Z; Ma, J; Wang, M; Wu, M | 1 |
| Ji, J; Peng, Y; Rakesh, KP; Wang, S; Xu, M; Zhu, L | 1 |
| Amin, KM; Elsawah, MM; Mahmoud, WR; Nissan, YM; Ragab, MF; Refaey, RH | 1 |
| Bajda, M; Godyń, J; Hagenow, S; Kieć-Kononowicz, K; Kuder, K; Malawska, B; Stark, H; Stawarska, E; Zaręba, P; Łątka, K; Łażewska, D | 1 |
| Gobec, S; Godyń, J; Jończyk, J; Knez, D; Malawska, B; Panek, D; Pasieka, A; Sabaté, R; Valdivieso, ÁDR; Wichur, T; Więckowska, A; Więckowski, K | 1 |
| do Carmo Carreiras, M; Ismaili, L; Marco-Contelles, J | 1 |
| Cui, Z; Gao, J; Geng, H; Li, D; Li, H; Zhou, B; Zhou, L | 1 |
| Benek, O; Benkova, M; Dolezal, R; Hepnarova, V; Hrabinova, M; Janockova, J; Jun, D; Kobrlova, T; Korabecny, J; Kucera, T; Mezeiova, E; Prchal, L; Sobolova, K; Soukup, O | 1 |
| Gabr, M; Murugan, NA | 1 |
| Chen, Y; Feng, F; He, S; Li, Q; Liao, Q; Liu, W; Liu, Y; Lu, W; Sun, H; Xing, S; Xiong, B; Yang, H | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Du, H; Jiang, X; Liu, S; Ma, F; Ma, M; Xu, H | 1 |
| Boulouard, M; Claeysen, S; Corvaisier, S; Dallemagne, P; Davis, A; Freret, T; Hatat, B; Lalut, J; Lecoutey, C; Rochais, C; Since, M; Sopková-de Oliveira Santos, J; Toublet, FX | 1 |
| Baiula, M; Bolognesi, ML; Kobrlova, T; Mercolini, L; Monti, B; Petralla, S; Protti, M; Rossi, M; Soukup, O; Spampinato, SM | 1 |
| Chen, T; Chen, Y; Feng, F; Jiang, X; Li, Q; Liu, C; Liu, W; Lyu, W; Sun, H; Wang, S; Wang, Y; Xing, C | 1 |
| Andrys, R; Capek, J; Handl, J; Hrabinova, M; Janockova, J; Kobrlova, T; Korabecny, J; Marco-Contelles, JL; Mezeiova, E; Micankova, P; Muckova, L; Nepovimova, E; Pejchal, J; Rousar, T; Simunkova, M; Soukup, O; Valko, M | 1 |
| Kumar, S; Mishra, S; Modi, G; Rai, H; Singh, G; Singh, GK; Singh, YP; Srikrishna, S | 1 |
| Angeloni, C; Bartolini, M; Bergamini, C; Bolognesi, ML; Chantegreil, F; de Camargo Nascente, L; de Melo Viana Teixeira, S; Freschi, M; Hrelia, S; Malaguti, M; Nachon, F; Prchal, L; Rossi, M; Salerno, A; Soares Romeiro, LA; Soukup, O | 1 |
| Brazzolotto, X; Chantegreil, F; Dias, J; Gobec, S; Godyń, J; Höfner, G; Jończyk, J; Knez, D; Korabecny, J; Latacz, G; Lu, J; Malawska, B; Mezeiova, E; Panek, D; Pasieka, A; Pi, R; Szałaj, N; Tabor, J; Wanner, K; Więckowska, A | 1 |
| Chen, Y; Feng, F; He, S; Li, Q; Liao, Q; Liu, W; Lu, W; Sun, H; Wang, Y; Xing, S; Xiong, B | 1 |
| Brazzolotto, X; Bucki, A; Gobec, S; Godyń, J; Góral, I; Głuch-Lutwin, M; Honkisz-Orzechowska, E; Knez, D; Kołaczkowski, M; Latacz, G; Malawska, B; Panek, D; Pasieka, A; Sabate, R; Siwek, A; Wichur, T; Więckowska, A | 1 |
| Brazzolotto, X; Bucki, A; Gobec, S; Godyń, J; Góral, I; Głuch-Lutwin, M; Jukič, M; Knez, D; Kołaczkowski, M; Latacz, G; Malawska, B; Mordyl, B; Sałat, K; Siwek, A; Śniecikowska, J; Walczak, M; Wichur, T; Więckowska, A | 1 |
| Cheung, K; Fu, G; Fu, L; Hu, Y; Ip, FCF; Ip, NY; Kang, F; Ling, CY; Sun, P; Xie, F; Yang, F | 1 |
| Fan, L; Lei, F; Liu, Y; Sheng, K; Song, Y; Wu, L; Wu, S; Zhang, Y; Zhao, W | 1 |
| Chen, S; Du, J; Li, R; Li, Z; Liu, T; Xing, S | 1 |
| Bayomi, SM; El-Subbagh, HI; Ghaly, MA; Saad, KM; Waly, OM | 1 |
| Du, C; Du, K; Feng, C; Lv, W; Shen, R; Sun, H; Xi, M | 1 |
| Amoroso, R; Carradori, S; De Filippis, B; Fantacuzzi, M | 1 |
| Chen, L; Lei, Z; Sun, J; Sun, X; Wang, Y; Yue, S | 1 |
| Andricopulo, AD; Cenci, AR; de Oliveira, AS; Ferreira, LLG; Machado, V; Nunes, RJ; Sandjo, LP; Sens, L; Teixeira, KF; Tizziani, T; Yunes, RA | 1 |
| Fujii, T; Fujimoto, K; Kawashima, K; Sato, A; Suzuki, T; Yoshizawa, M | 1 |
| Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M | 1 |
| Palacios, JM | 1 |
| Schneider, LS | 2 |
| Cheng, DH; Ren, H; Tang, XC | 1 |
| Fricker, J | 1 |
| Nichols, ME | 1 |
| Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H | 1 |
| Kojima, J; Nakajima, K; Nakayama, K; Ochiai, M | 1 |
| Geldmacher, DS | 1 |
| Henry, RG; Wekstein, DR | 1 |
| Honma, A | 1 |
| Braida, D; Colibretti, L; Griffini, P; Lamperti, M; Paladini, E; Sala, M | 1 |
| Nordberg, A; Svensson, AL | 1 |
| Cheng, DH; Tang, XC | 1 |
| Tang, XC; Wang, T | 1 |
| Peskind, ER | 1 |
| Cummings, JL | 1 |
| Sunderland, T; Tune, LE | 1 |
| Lacomblez, L | 1 |
| Derquesné, C | 1 |
| Larson, EB; Shadlen, MF | 1 |
| Hecker, J | 1 |
| Hu, GY; Lin, JH; Tang, XC | 1 |
| Cross, AJ; De Souza, RJ; Green, AR; Misra, A; Murray, TK; Snape, MF; Williams, JL | 1 |
| Pryse-Phillips, W | 1 |
| Tang, XC; Wang, H | 1 |
| Dom, R; Lemière, J; Van Gool, D | 1 |
| Trabucchi, M | 1 |
| Kosasa, T; Kuriya, Y; Matsui, K; Yamanishi, Y | 3 |
| Kosasa, T; Kuriya, Y; Yamanishi, Y | 1 |
| Burns, A; Page, S; Russell, E | 1 |
| Kaur, J; Zhang, MQ | 1 |
| Mumenthaler, MS; O'Hara, R; Yesavage, JA | 1 |
| Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H | 1 |
| Danysz, W; Moebius, HJ; Quack, G; Wenk, GL | 1 |
| Cummings, J; Fillit, H | 1 |
| Beyreuther, K; Emilien, G; Maloteaux, JM; Masters, CL | 1 |
| Braida, D; Ottonello, F; Sala, M; Virag, W | 1 |
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62 review(s) available for tacrine and donepezil
| Article | Year |
|---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium Channel Blockers; Chelating Agents; Cholinesterase Inhibitors; Humans; Huntington Disease; Ligands; Multiple Sclerosis; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurotransmitter Agents; Parkinson Disease; Plaque, Amyloid | 2008 |
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Ligands; Neuroprotective Agents | 2019 |
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Triazoles | 2019 |
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cholinesterases; Humans; Ligands; Monoamine Oxidase; Neuroprotective Agents; Oxidative Stress; Pargyline; Propylamines | 2020 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Coumaric Acids; Humans; Neuroprotective Agents; Oxidative Stress; Protein Multimerization | 2021 |
Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Fluorescent Dyes; Humans; Molecular Structure; Neoplasms; Tetralones | 2022 |
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.
Topics: Humans; Neurodegenerative Diseases; Polyphenols; Resveratrol; Stilbenes; Structure-Activity Relationship | 2022 |
New therapeutic approaches to Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Carbamates; Cholinergic Agents; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon | 1996 |
Dementia in the elderly.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Piperidines; Tacrine; United States | 1997 |
Providing dental care for patients diagnosed with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Caregivers; Cholinesterase Inhibitors; Dental Care for Chronically Ill; Dentist-Patient Relations; Donepezil; Family Relations; Humans; Indans; Middle Aged; Nootropic Agents; Oral Hygiene; Piperidines; Prevalence; Professional-Family Relations; Tacrine | 1997 |
[Therapeutic agents for Alzheimer's disease].
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Monoamine Oxidase Inhibitors; Neuropeptides; Phenylcarbamates; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Rivastigmine; Spiro Compounds; Tacrine | 1998 |
Pharmacologic approaches to cognitive deficits in Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Nootropic Agents; Piperidines; Placebos; Tacrine; Treatment Outcome; Trichlorfon | 1998 |
New therapeutic approaches to cognitive impairment.
Topics: Aged; Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Humans; Indans; Monoamine Oxidase Inhibitors; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon | 1998 |
New cholinergic therapies: treatment tools for the psychiatrist.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens; Female; Humans; Indans; Male; Piperidines; Selective Serotonin Reuptake Inhibitors; Selegiline; Tacrine; Vitamin E | 1998 |
What's new in Alzheimer's disease treatment? Reasons for optimism about future pharmacologic options.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines; Tacrine | 1999 |
Alzheimer's disease: the advent of effective therapy.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Diagnostic Imaging; Donepezil; Female; Humans; Indans; Male; Piperidines; Risk Factors; Tacrine | 1998 |
Do we have drugs for dementia? No.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Ginkgo biloba; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Piperidines; Plants, Medicinal; Selegiline; Tacrine; Vitamin E | 1999 |
Treatment of Alzheimer's disease: an evaluation of the cholinergic approach.
Topics: Acetylcholine; Alzheimer Disease; Animals; Carbamates; Chemical and Drug Induced Liver Injury; Cholinergic Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Rivastigmine; Tacrine | 1999 |
An economic perspective on Alzheimer's disease.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Combined Modality Therapy; Cost of Illness; Costs and Cost Analysis; Donepezil; Humans; Indans; Institutionalization; Italy; Mental Health Services; Neuropsychological Tests; Piperidines; Reality Therapy; Tacrine | 1999 |
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine | 2000 |
Prospects for pharmacological intervention in Alzheimer disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartic Acid Endopeptidases; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Endopeptidases; Hippocampus; Humans; Indans; N-Methylaspartate; Nerve Growth Factors; Nicotine; Piperidines; Tacrine | 2000 |
Cholinesterase inhibitors stabilize Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon | 2000 |
Cholinesterase inhibitors for Alzheimer's disease.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cost-Benefit Analysis; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
Approaches to memory loss in neuropsychiatric disorders.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Dementia; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Memory Disorders; Nootropic Agents; Piperidines; Premenopause; Randomized Controlled Trials as Topic; Tacrine | 2000 |
Use of cholinesterase inhibitors for treatment of Alzheimer disease.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
[Current strategies of pathogenetic therapy of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amino Acids; Aminoquinolines; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Estrogens; Ginkgo biloba; Humans; Indans; Memantine; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuronal Plasticity; Neuroprotective Agents; Neurotransmitter Agents; Nicergoline; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Piracetam; Pyrithioxin; Rivastigmine; Selegiline; Tacrine; Time Factors | 2001 |
[Perspectives for drug treatment in Alzheimer's disease].
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine.
Topics: Acetylcholine; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Disease Progression; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome | 2002 |
Clinical use of cholinomimetic agents: a review.
Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Brain Injuries; Carbamates; Clinical Trials as Topic; Cytidine Diphosphate Choline; Donepezil; Female; Follow-Up Studies; Humans; Indans; Injections, Intravenous; Injury Severity Score; Male; Middle Aged; Parasympathomimetics; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2002 |
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.
Topics: Aging; Alzheimer Disease; Biological Availability; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Half-Life; Humans; Indans; Intestinal Absorption; Liver; Phenylcarbamates; Piperidines; Protein Binding; Rivastigmine; Tacrine; Tissue Distribution | 2002 |
Medical treatment of Alzheimer's disease: past, present, and future.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forecasting; Galantamine; Humans; Indans; Male; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2002 |
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Binding Sites; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Molecular Conformation; Molecular Structure; Phenylcarbamates; Piperidines; Rivastigmine; Structure-Activity Relationship; Tacrine | 2001 |
[Anti-dementia drugs for Alzheimer disease in present and future].
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; tau Proteins | 2002 |
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Topics: Alkaloids; Cholinesterase Inhibitors; Donepezil; Indans; Molecular Conformation; Molecular Structure; Piperidines; Sesquiterpenes; Tacrine | 2002 |
Dementia.
Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E | 2003 |
[Current therapy of patients with dementia].
Topics: Activities of Daily Living; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Controlled Clinical Trials as Topic; Dementia; Dementia, Vascular; Donepezil; Dopamine Agents; Female; Galantamine; Ginkgo biloba; Humans; Indans; Male; Memantine; Meta-Analysis as Topic; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Placebos; Plant Preparations; Prospective Studies; Rivastigmine; Tacrine; Time Factors | 2003 |
Acetylcholinesterase inhibition in Alzheimer's Disease.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2004 |
[Drugs for the treatment of Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Antidepressive Agents; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Indans; Injections, Intramuscular; Physostigmine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tacrine | 2004 |
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies.
Topics: Aged; Basal Ganglia Diseases; Behavior; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Cognition Disorders; Donepezil; Humans; Indans; Lewy Body Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Tacrine | 2004 |
Dementia.
Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E | 2004 |
Dementia.
Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine | 2004 |
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2005 |
Dementia.
Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine | 2005 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2006 |
[Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Humans; Indans; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine | 2006 |
The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Geriatric Assessment; Humans; Indans; Mental Disorders; Nootropic Agents; Phenylcarbamates; Piperidines; Positron-Emission Tomography; Rivastigmine; Tacrine | 2007 |
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.
Topics: Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Indole Alkaloids; Isoquinolines; Phenylcarbamates; Physostigmine; Piperidines; Propidium; Rivastigmine; Steroids; Tacrine | 2007 |
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine | 2008 |
Diagnosis and treatment of dementia with Lewy bodies.
Topics: Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Nootropic Agents; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Tacrine | 2008 |
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation.
Topics: Acetylcholinesterase; Animals; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Indans; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine; Up-Regulation | 2009 |
New drugs for Alzheimer's disease in Japan.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Japan; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2011 |
Effective pharmacological management of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome | 2011 |
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Ligands; Piperidines; Tacrine | 2017 |
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; Humans; Indans; Opioid Peptides; Pain; Piperidines; Tacrine | 2017 |
Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Humans; Indans; Inhibitory Concentration 50; Piperidines; Rivastigmine; Tacrine | 2017 |
The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Chemistry Techniques, Synthetic; Donepezil; Dopamine Agents; Drug Design; Drug Discovery; Humans; Indans; Memantine; Molecular Targeted Therapy; Neuroprotective Agents; Nootropic Agents; Rivastigmine; Tacrine | 2019 |
Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Rivastigmine; Tacrine | 2019 |
Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Repositioning; Galantamine; Humans; Rivastigmine; Tacrine | 2019 |
Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology.
Topics: Central Nervous System Agents; Central Nervous System Diseases; Cholinesterases; Combined Modality Therapy; Donepezil; Drug Design; Enzyme Inhibitors; Galantamine; Humans; Monoamine Oxidase; Rivastigmine; Structure-Activity Relationship; Tacrine | 2020 |
Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer's Disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Donepezil; Humans; Ligands; Tacrine | 2023 |
Chromone Containing Hybrid Analogs: Synthesis and Applications in Medicinal Chemistry.
Topics: Chemistry, Pharmaceutical; Chromones; Donepezil; Drug Discovery; Structure-Activity Relationship; Tacrine | 2023 |
2 trial(s) available for tacrine and donepezil
| Article | Year |
|---|---|
The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients.
Topics: Acetylcholine; Aged; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Electroencephalography; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Prospective Studies; Reaction Time; Rivastigmine; Tacrine; Treatment Outcome | 2003 |
Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study.
Topics: Adult; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Middle Aged; Pilot Projects; Piperidines; Prepulse Inhibition; Pyrazoles; Pyrimidines; Reaction Time; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Scopolamine; Serotonin Antagonists; Tacrine; Treatment Outcome; Young Adult | 2014 |
204 other study(ies) available for tacrine and donepezil
| Article | Year |
|---|---|
QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.
Topics: Cholinesterase Inhibitors; Indans; Models, Molecular; Piperidines; Structure-Activity Relationship | 1992 |
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.
Topics: Animals; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Molecular Conformation; Rats; Structure-Activity Relationship; Thiourea | 1995 |
Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.
Topics: Animals; Benzothiazoles; Butyrylcholinesterase; Cholinesterase Inhibitors; Corpus Striatum; Drug Design; Male; Mice; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles | 1995 |
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Avoidance Learning; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computer Graphics; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Morpholines; Piperidines; Prosencephalon; Structure-Activity Relationship | 1994 |
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Models, Molecular; Piperidines | 1996 |
Aminopyridazines as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Neostriatum; Piperidines; Pyridazines; Rats; Structure-Activity Relationship | 1999 |
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Models, Molecular; Molecular Conformation; Piperidines; Pyridazines; Pyridines; Structure-Activity Relationship; Torpedo | 2001 |
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
Topics: Acetylcholinesterase; Donepezil; Drug Evaluation, Preclinical; Indans; Indoles; Luminescent Measurements; Models, Molecular; Nootropic Agents; Piperidines; Pyrroles; Structure-Activity Relationship | 2001 |
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship | 2002 |
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Ligands; Models, Molecular; Structure-Activity Relationship; Tacrine | 2003 |
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Piperidines; Polyamines; Structure-Activity Relationship | 2004 |
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.
Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Benzofurans; Butyrylcholinesterase; Carbamates; Cell Line; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neurons; Oxepins; Structure-Activity Relationship | 2005 |
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Topics: Acetylcholinesterase; Acridines; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; In Vitro Techniques; Ligands; Models, Molecular; Molecular Probes; Structure-Activity Relationship | 2005 |
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Topics: Acetylcholinesterase; Animals; Binding Sites; Cattle; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Tacrine | 2005 |
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cell Line, Tumor; Cholinesterase Inhibitors; Dimerization; Drug Design; Erythrocytes; Fluorometry; Humans; Models, Molecular; Nootropic Agents; Protein Binding; Structure-Activity Relationship; Tacrine | 2005 |
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo | 2006 |
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Acylation; Alkylation; Animals; Benzene; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Imidazoles; Inhibitory Concentration 50; Kinetics; Luminescent Measurements; Thiazoles | 2008 |
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Molecular Structure; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Structure-Activity Relationship | 2007 |
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Humans; Ligands; Models, Molecular; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Polyamines; Protein Binding; Quinones; Reactive Oxygen Species; Structure-Activity Relationship; Substrate Specificity | 2007 |
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Structure-Activity Relationship; Tacrine | 2008 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.
Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Computational Biology; Drug Design; Models, Chemical; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship | 2010 |
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.
Topics: Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Inhibitory Concentration 50; Models, Biological; Models, Molecular; Molecular Structure; Pyrans | 2011 |
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cations; Cholinesterase Inhibitors; Dimerization; Heterocyclic Compounds; Models, Molecular; Quaternary Ammonium Compounds | 2011 |
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Crystallography, X-Ray; Dose-Response Relationship, Drug; Erythrocytes; Models, Molecular; Molecular Structure; Quinolizidines; Stereoisomerism; Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Isoenzymes; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Piperidines; Rats; Structure-Activity Relationship | 2011 |
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Heterocyclic Compounds; Humans; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Peptide Fragments; Propylamines; Protein Multimerization; Protein Structure, Secondary; Rats | 2012 |
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Chelating Agents; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Kinetics; Metals; Pyridines; Structure-Activity Relationship | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Topics: Alkaloids; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Cell Line; Chromatography, Affinity; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Dioxoles; Dyrk Kinases; Glutamic Acid; Humans; Imidazoles; In Vitro Techniques; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Porifera; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2012 |
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Coumarins; Horses; Humans | 2013 |
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Drug Design; Indans; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Structure-Activity Relationship | 2013 |
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Caffeine; Catalytic Domain; Cholinesterase Inhibitors; Humans; Hydrogen Bonding; Molecular Docking Simulation; Pentoxifylline; Protein Binding; Thermodynamics; Xanthine; Xanthines | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine | 2013 |
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Azoles; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Electrophorus; Glutathione Peroxidase; Humans; Indans; Isoindoles; Kinetics; Ligands; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Organoselenium Compounds; Peptide Fragments; Peroxynitrous Acid; Piperidines; Protein Multimerization; Protein Structure, Secondary; Thioredoxin-Disulfide Reductase; Toxicity Tests, Acute | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Azoles; Biocompatible Materials; Butyrylcholinesterase; Cholinesterase Inhibitors; Glutathione Peroxidase; Humans; Isoindoles; Organoselenium Compounds; Protein Binding | 2014 |
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Binding Sites; Catalytic Domain; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Piperidines; Quinolones; Structure-Activity Relationship | 2014 |
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates | 2014 |
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzylamines; Cell Line, Tumor; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Phthalimides; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship | 2015 |
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Delivery Systems; Drug Design; Drug Evaluation, Preclinical; Horses; Humans; Indoles; Protein Structure, Secondary | 2015 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2015 |
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.
Topics: Amines; Benzylidene Compounds; Catalytic Domain; Cholinesterase Inhibitors; Chromones; Cyclization; Drug Design; Inhibitory Concentration 50; Models, Molecular | 2015 |
Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Flavins; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Structure-Activity Relationship | 2015 |
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Binding Sites; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Computer Simulation; Coumarins; Drug Evaluation, Preclinical; Galantamine; Humans; Hydrogen Peroxide; Male; Mice, Inbred BALB C; Models, Molecular; Neuroprotective Agents; Neurotoxicity Syndromes | 2016 |
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carboxylesterase; Cholinesterase Inhibitors; Enzyme Inhibitors; Horses; Humans; Molecular Docking Simulation; Swine; Thiazoles | 2016 |
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Donepezil; Dose-Response Relationship, Drug; Drug Design; Eels; Humans; Indans; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Structure-Activity Relationship | 2016 |
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Scopoletin; Structure-Activity Relationship | 2016 |
Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Cyclohexanones; Drug Design; Humans; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Protein Aggregates; Rats | 2016 |
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Drug Design; Humans; Molecular Docking Simulation; Molecular Targeted Therapy; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Pyridines; Triazines | 2016 |
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Humans; Kinetics; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Protein Conformation; Pyrimidines | 2016 |
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Male; Mice; Molecular Structure; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2016 |
Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Binding Sites; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2016 |
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Urea | 2016 |
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.
Topics: Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2016 |
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Carbon-13 Magnetic Resonance Spectroscopy; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Monoamine Oxidase Inhibitors; Neuroprotective Agents; PC12 Cells; Proton Magnetic Resonance Spectroscopy; Rats; Spectrometry, Mass, Electrospray Ionization; Tetralones | 2016 |
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.
Topics: Acetylcholinesterase; Amines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Kinetics; Ligands; Molecular Docking Simulation; Piperidines; Receptors, Histamine H3; Structure-Activity Relationship | 2016 |
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Iron; Kinetics; Melatonin; Molecular Docking Simulation; Peptide Fragments; Piperidines; Protein Multimerization; Rats; Zinc | 2016 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation | 2016 |
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Ligands; Male; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Rats; Rats, Wistar; Receptors, Serotonin | 2016 |
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
Topics: Amines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Binding Sites; Blood-Brain Barrier; Cholinesterases; Drug Delivery Systems; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregation, Pathological; Protein Binding; Saccharin | 2017 |
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzyl Compounds; Binding Sites; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Piperidines; Protein Aggregation, Pathological; Protein Binding; Structure-Activity Relationship | 2017 |
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Drug Design; Electrophorus; Indans; Kinetics; Mice; Molecular Docking Simulation; NIH 3T3 Cells; Piperidines; Protein Conformation; Structure-Activity Relationship | 2016 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species | 2017 |
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazines | 2017 |
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Animals; Cholinesterase Inhibitors; Donepezil; Drug Design; Female; Humans; Indans; Mice; Molecular Docking Simulation; Piperidines; Prodrugs | 2017 |
New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Death; Cell Proliferation; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hydrogen Peroxide; Molecular Structure; Neuroprotective Agents; PC12 Cells; Phthalazines; Protein Aggregates; Pyrazoles; Rats; Structure-Activity Relationship | 2017 |
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cinnamates; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycogen Synthase Kinase 3 beta; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2017 |
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiosemicarbazones; Tumor Cells, Cultured | 2017 |
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.
Topics: Acetylcholinesterase; Allosteric Regulation; Alzheimer Disease; Binding Sites; Cell Proliferation; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cell Proliferation; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Eels; Horses; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Aggregates; Pyridines; Structure-Activity Relationship | 2017 |
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dihydropyridines; Dose-Response Relationship, Drug; Electrophorus; Horses; Molecular Docking Simulation; Molecular Structure; Prodrugs; Pyridinium Compounds; Salts; Structure-Activity Relationship | 2018 |
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Line, Tumor; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Aggregates; Range of Motion, Articular; Structure-Activity Relationship; Thiocarbamates | 2018 |
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Butyrylcholinesterase; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Horses; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Pyridines; Structure-Activity Relationship; Torpedo | 2018 |
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; Caco-2 Cells; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Models, Molecular; Neuroprotective Agents; Piperidines | 2018 |
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Carbazoles; Cholinesterase Inhibitors; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Piperidines; Rats | 2018 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Targeted Therapy; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 2018 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles | 2019 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer's Disease.
Topics: | 2019 |
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protective Agents; Protein Multimerization; Rats; Structure-Activity Relationship; Sulfonamides | 2019 |
Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Male; Mice; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2019 |
Search for new multi-target compounds against Alzheimer's disease among histamine H
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzopyrans; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Histamine H3 Antagonists; Horses; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Piperidines; Receptors, Histamine H3; Structure-Activity Relationship | 2020 |
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Fluorescence Recovery After Photobleaching; Horses; Humans; Molecular Structure; Protein Aggregates; Pyrrolidines; Structure-Activity Relationship; Sulfonic Acids | 2020 |
Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.
Topics: Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Discovery; Humans; Inhibitory Concentration 50; Isoquinolines; Molecular Docking Simulation; Structure-Activity Relationship | 2020 |
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.
Topics: Berberine; Blood-Brain Barrier; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Prolyl Oligopeptidases | 2020 |
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands.
Topics: Acetylcholinesterase; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Molecular Docking Simulation; Neurodegenerative Diseases; Neuroprotective Agents; Protein Aggregates; Pyrazoles; tau Proteins | 2020 |
Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor.
Topics: Aminoquinolines; Animals; Benzimidazoles; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Female; Humans; Male; Mice, Inbred ICR; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuroprotective Agents; Protein Binding; Small Molecule Libraries | 2020 |
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Carbolines; Cell Line; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological | 2020 |
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Humans; Locomotion; Male; Mice; Models, Molecular; Molecular Structure; Prodrugs; Receptors, Serotonin; Structure-Activity Relationship | 2021 |
α-Linolenic Acid-Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis.
Topics: | 2020 |
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Glycogen Synthase Kinase 3 beta; Humans; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Pyridines; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2021 |
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Drug Design; Humans; Naphthoquinones; Structure-Activity Relationship | 2021 |
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anacardium; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Line; Cell Survival; Cytokines; Drug Design; Humans; Ligands; Lipopolysaccharides; Microglia; Molecular Dynamics Simulation; Neuroprotective Agents; Nuts; Plant Extracts; Structure-Activity Relationship; Tacrine | 2021 |
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Topics: Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; GABA Plasma Membrane Transport Proteins; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship | 2021 |
Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.
Topics: Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; Drug Design; Ghrelin; Half-Life; Humans; Mice; Mice, Inbred ICR; Molecular Dynamics Simulation; Neuroprotective Agents; Peptide Fragments; Quinolines; Rats, Sprague-Dawley; Structure-Activity Relationship; Up-Regulation | 2021 |
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Proliferation; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electrophorus; Hep G2 Cells; Horses; Humans; Indoles; Ligands; Mice; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Protein Aggregates; Receptors, Serotonin; Structure-Activity Relationship; tau Proteins | 2021 |
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Development; Electrophorus; Hep G2 Cells; Horses; Humans; Male; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Receptors, Serotonin; Structure-Activity Relationship | 2021 |
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Quinolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Synaptic Transmission; Tacrine | 2021 |
Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Biphenyl Compounds; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Neuroprotective Agents; Oxadiazoles; Picrates; Protein Aggregates; Structure-Activity Relationship | 2022 |
Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Models, Molecular; Neuroprotective Agents; Tacrine | 2022 |
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2022 |
Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Binding Sites; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Rats | 2022 |
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies.
Topics: | 2022 |
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Male; Movement; Physostigmine; Piperidines; Radioimmunoassay; Rats; Rats, Wistar; Tacrine | 1994 |
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1996 |
Alzheimer's disease: new pharmacological perspectives.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Dihydropyridines; Donepezil; Humans; Indans; Muscarinic Agonists; Oximes; Phenylcarbamates; Piperidines; Pyridines; Rivastigmine; Tacrine; Thiadiazoles | 1996 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1996 |
From mechanisms to drugs in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dioxoles; Donepezil; Humans; Indans; Memory, Short-Term; Piperidines; Rats; Tacrine | 1997 |
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed | 1997 |
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Motor Activity; Piperidines; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine; Tacrine | 1997 |
Donepezil (Aricept) therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tacrine | 1997 |
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Topics: Amnesia; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Male; Maze Learning; Morpholines; Motor Activity; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1998 |
Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.
Topics: Adrenal Gland Neoplasms; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; Donepezil; Indans; Mecamylamine; Neurons; Neuroprotective Agents; Neurotoxins; Nicotinic Antagonists; PC12 Cells; Peptide Fragments; Pheochromocytoma; Piperidines; Rats; Tacrine; Tubocurarine | 1998 |
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
Topics: Alkaloids; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Injections, Intraventricular; Male; Maze Learning; Memory; Memory, Short-Term; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1998 |
Advances in diagnosing and treating Alzheimer's disease.
Topics: Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tacrine | 1998 |
Alzheimer's disease management.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Piperidines; Selegiline; Tacrine; Vitamin E | 1998 |
[Drug therapy strategies in Alzheimer's disease].
Topics: Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Depression; Donepezil; Humans; Indans; Mental Disorders; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Sleep Wake Disorders; Tacrine | 1998 |
[Alzheimer's disease. Foreword].
Topics: Age Factors; Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 1998 |
Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
Topics: Action Potentials; Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; Indans; Male; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Neuromuscular Junction; Phrenic Nerve; Piperidines; Sesquiterpenes; Tacrine | 1997 |
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carbachol; Cholinesterase Inhibitors; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Indoles; Injections, Intraperitoneal; Isoquinolines; Logistic Models; Male; Physostigmine; Piperidines; Rats; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured | 1999 |
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats.
Topics: Acetylcholine; Acetylcholinesterase; Administration, Oral; Animals; Brain; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Indans; Male; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine | 1999 |
Effect of donepezil hydrochloride (E2020) on extracellular acetylcholine concentration in the cerebral cortex of rats.
Topics: Animals; Benzazepines; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Electrochemistry; Extracellular Space; Indans; Male; Microdialysis; Nootropic Agents; Peripheral Nervous System; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine | 1999 |
Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats.
Topics: Aging; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Erythrocytes; Indans; Male; Peripheral Nervous System; Piperidines; Rats; Rats, Inbred F344; Tacrine | 1999 |
New drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Carbamates; Donepezil; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Rivastigmine; Tacrine | 1999 |
Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats.
Topics: Administration, Oral; Alzheimer Disease; Animals; Benzazepines; Brain; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Male; Memory; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine | 2000 |
Update on Alzheimer's disease: recent findings and treatments.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Risk Factors; Tacrine | 2000 |
Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.
Topics: Acetylcholine; Age Factors; Animals; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Extracellular Space; Glucose; Indans; Macaca mulatta; Male; Microdialysis; Neurons; Physostigmine; Piperidines; Tacrine; Tomography, Emission-Computed; Wakefulness | 2000 |
No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Memantine; Piperidines; Rats; Rats, Inbred F344; Tacrine | 2000 |
Practice guidelines for the diagnosis and treatment of Alzheimer's disease in a managed care setting: Part II--Pharmacologic therapy. Alzheimer's Disease (AD) Managed Care Advisory Council.
Topics: Algorithms; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caregivers; Cholinesterase Inhibitors; Clinical Trials as Topic; Cost-Benefit Analysis; Donepezil; Drug Interactions; Estrogens; Female; Ginkgo biloba; Humans; Indans; Male; Managed Care Programs; Nootropic Agents; Patient Selection; Phytotherapy; Piperidines; Plants, Medicinal; Psychotropic Drugs; Quality of Health Care; Selegiline; Tacrine; Time Factors; Vitamin E | 2000 |
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine | 2000 |
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
Topics: Animals; Avoidance Learning; Basal Nucleus of Meynert; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning Disabilities; Male; Maze Learning; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 2000 |
The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different.
Topics: Aged; Alzheimer Disease; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, Nicotinic; Rivastigmine; Tacrine | 2000 |
Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat.
Topics: Animals; Body Temperature; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Hypothermia; Indans; Lacrimal Apparatus; Male; Phenylcarbamates; Piperidines; Rats; Rivastigmine; Saliva; Tacrine; Tremor; Trichlorfon | 2000 |
[Treatment of the elderly dementia patients].
Topics: Aged; Alzheimer Disease; Benzazepines; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Piperidines; Tacrine; Trichlorfon | 2000 |
Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Animals; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Inhibitory Concentration 50; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rivastigmine; Tacrine; Time Factors | 2000 |
Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats.
Topics: Acetylcholinesterase; Animals; Benzazepines; Benzoxazines; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Fasciculation; Indans; Male; Muscarinic Antagonists; Oxazines; Piperidines; Rats; Rats, Wistar; Tacrine; Yawning | 2001 |
Medications for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
Maintaining functional and behavioral abilities in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Treatment Outcome | 2001 |
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Choline O-Acetyltransferase; Cognition; Donepezil; Dose-Response Relationship, Drug; Enzyme Induction; Hippocampus; Indans; Male; Maze Learning; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2001 |
Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Cholinesterases; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Humans; Indans; Male; Phenothiazines; Piperidines; Quinolines; Rats; Rats, Wistar; Salivation; Tacrine; Temperature | 2002 |
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Memory Disorders; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2002 |
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Carbamates; Cholinesterase Inhibitors; Cognition; Donepezil; Evaluation Studies as Topic; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Piperidines; Reaction Time; Rivastigmine; Sensitivity and Specificity; Severity of Illness Index; Tacrine | 2001 |
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Animals; Benzazepines; Brain; Brain Ischemia; Cholinesterase Inhibitors; Coloring Agents; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Neuroprotective Agents; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine; Tetrazolium Salts | 2002 |
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine | 2002 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; Indans; Mice; Neuroblastoma; Piperidines; Protective Agents; Rats; Staurosporine; Tacrine | 2002 |
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Middle Aged; Phenylcarbamates; Piperidines; Product Surveillance, Postmarketing; Rivastigmine; Surveys and Questionnaires; Tacrine; Treatment Outcome | 2003 |
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
Topics: Allosteric Regulation; Animals; Carbamates; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Mice; Neurons; Phenylcarbamates; Piperidines; Receptors, Muscarinic; Receptors, Nicotinic; Recombinant Fusion Proteins; Rivastigmine; Tacrine; Trichlorfon | 2003 |
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine | 2004 |
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Ligands; Models, Molecular; Nootropic Agents; Piperidines; Rats; Structure-Activity Relationship; Tacrine | 2004 |
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Electric Stimulation; Galantamine; In Vitro Techniques; Indans; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Receptors, Purinergic; Rivastigmine; Stimulation, Chemical; Synaptic Transmission; Tacrine; Vas Deferens | 2004 |
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
Topics: Animals; Apoptosis; Cells, Cultured; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Glutamic Acid; Indans; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine | 2005 |
Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Cell Line, Transformed; Central Nervous System Agents; Choline; Cyclic N-Oxides; Donepezil; Endothelial Cells; Indans; Models, Biological; Nerve Tissue Proteins; Nitrogen Oxides; Organic Cation Transport Proteins; Piperidines; Plasma Membrane Neurotransmitter Transport Proteins; Rats; Symporters; Tacrine | 2005 |
Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cohort Studies; Cross-Sectional Studies; Databases, Factual; Dementia; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Nursing Homes; Piperidines; Proportional Hazards Models; Retrospective Studies; Tacrine | 2005 |
Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Models, Chemical; Models, Molecular; Molecular Structure; Piperidines; Protein Structure, Secondary; Tacrine | 2006 |
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Hippocampus; Indans; Isoflurophate; Membrane Potentials; Neurons; Nimodipine; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Tacrine; Time Factors | 2006 |
Pharmacological characterization of orally active cholinesterase inhibitory activity of Prunus persica L. Batsch in rats.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Male; Piperidines; Plant Extracts; Prunus; Rats; Rats, Wistar; Tacrine; Tissue Extracts | 2006 |
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Indans; Inflammation; Injections, Intraperitoneal; Interleukin-2; Lipopolysaccharides; Mice; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2007 |
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Autopsy; Cerebral Cortex; Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Donepezil; Drug Evaluation; Female; Galantamine; Humans; Indans; Lewy Body Disease; Male; Middle Aged; Neuroprotective Agents; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine; Tacrine; tau Proteins; Tauopathies | 2007 |
Effect of histamine on muscimol-induced working memory deficits in radial maze performance.
Topics: Animals; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Histamine; Histidine; Indans; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Muscimol; Piperidines; Rats; Tacrine | 2007 |
Alzheimer's disease: will advances made in the past turn the tide?
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Memantine; Piperidines; Tacrine | 2007 |
Evaluation of centrally acting cholinesterase inhibitor exposures in adults.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gastrointestinal Diseases; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Poison Control Centers; Retrospective Studies; Rivastigmine; Tacrine | 2007 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezil; Glutathione; Indans; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Nootropic Agents; Oxidative Stress; Piperidines; Streptozocin; Tacrine | 2008 |
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine | 2008 |
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine | 2008 |
AAFP and ACP release guideline on dementia treatment.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Guidelines as Topic; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2008 |
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex.
Topics: Acetylcholine; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Galantamine; Humans; In Vitro Techniques; Indans; Middle Aged; Neocortex; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine; Young Adult | 2009 |
[Protection effects of acetylcholinesterase inhibitors on apoptosis].
Topics: Animals; Apoptosis; Cell Count; Cell Proliferation; Cell Survival; Chlorocebus aethiops; Cholinesterase Inhibitors; Donepezil; Drug Antagonism; HeLa Cells; Hepatitis B; Humans; Indans; Lipopolysaccharides; Piperidines; Tacrine; Vero Cells | 2008 |
The inhibitory avoidance test optimized for discovery of cognitive enhancers.
Topics: Animals; Avoidance Learning; Donepezil; Drug Evaluation, Preclinical; Drug Interactions; Indans; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Scopolamine; Tacrine | 2009 |
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain.
Topics: Acetylcholinesterase; Amidohydrolases; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Brain; Chick Embryo; Chickens; Cholinesterase Inhibitors; Donepezil; Enzyme Activation; Esterases; In Vitro Techniques; Indans; Isoflurophate; Piperidines; Tacrine | 2009 |
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acid Motifs; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Humans; Indans; Models, Molecular; Piperidines; Protein Multimerization; Protein Structure, Quaternary; Quinolines; Tacrine | 2010 |
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Galantamine; Half-Life; Hypothermia; Indans; Male; Metabolic Clearance Rate; Piperidines; Random Allocation; Rats; Rats, Inbred Strains; Receptor, Muscarinic M2; Salivation; Tacrine; Tears; Tremor | 2011 |
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Glutathione; Indans; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mitochondria; Motor Activity; Neurons; Nicotine; Piperidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Nicotinic; Streptozocin; Tacrine | 2011 |
Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures.
Topics: Acetylcholine; Animals; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Galantamine; Hippocampus; Indans; Mice; Mice, Inbred ICR; N-Methylaspartate; Organ Culture Techniques; Piperidines; Receptor, Muscarinic M1; Tacrine | 2013 |
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Quantitative Structure-Activity Relationship; Recombinant Proteins; Tacrine | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Hippocampus; Homocysteine; Hyperhomocysteinemia; Indans; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Nifedipine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Silver Staining; Tacrine | 2014 |
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential.
Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm | 2014 |
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
Topics: Animals; Cells, Cultured; Cholinergic Antagonists; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Muscarinic Antagonists; Muscle Fibers, Skeletal; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Tacrine | 2015 |
The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Quinuclidinyl Benzilate; Rats, Wistar; Tacrine | 2015 |
Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry.
Topics: Acetylcholine; Acetylcholinesterase; Ambenonium Chloride; Animals; Calorimetry; Cholinesterase Inhibitors; Donepezil; Edrophonium; Electrophorus; Fish Proteins; Galantamine; Indans; Kinetics; Piperidines; Tacrine; Thermodynamics | 2016 |
Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats--Is there a potential for Alzheimer's disease treatment?
Topics: Alzheimer Disease; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Piperidines; Quinuclidinyl Benzilate; Rats, Wistar; Tacrine | 2016 |
Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina.
Topics: Animals; Cholinesterase Inhibitors; Convulsants; Donepezil; Galantamine; Indans; Locomotion; Models, Biological; Piperidines; Planarians; Rivastigmine; Seizures; Survival Rate; Tacrine | 2016 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tacrine; Tandem Mass Spectrometry | 2016 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Gliosis; Hep G2 Cells; Hippocampus; Humans; Indans; Indoles; Learning; Male; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Plaque, Amyloid; Proof of Concept Study; Recognition, Psychology; Scopolamine; Tacrine | 2017 |
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Edrophonium; Enzymes, Immobilized; Galantamine; Humans; Indans; Kinetics; Ligands; Piperidines; Recombinant Fusion Proteins; Serum Albumin; Surface Plasmon Resonance; Tacrine | 2018 |
Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Survival; Cholinesterase Inhibitors; Donepezil; Kinetics; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Rats; Structure-Activity Relationship; Tacrine | 2020 |
Development of an Integrated Tissue Pretreatment Protocol for Enhanced MALDI MS Imaging of Drug Distribution in the Brain.
Topics: Animals; Aripiprazole; Brain; Brain Chemistry; Central Nervous System Agents; Clozapine; Donepezil; Haloperidol; Male; Mice; Mice, Inbred C57BL; Peritoneum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tacrine; Tissue Distribution | 2020 |
Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; Rivastigmine; Tacrine | 2021 |
Recent Modifications of Anti-dementia Agents Focusing on Tacrine and/or Donepezil Analogs.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Nootropic Agents; Tacrine | 2023 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma; Neurodegenerative Diseases; PTEN Phosphohydrolase; rho-Associated Kinases; Tacrine | 2022 |
Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Carboxylic Acids; Cholinesterase Inhibitors; Donepezil; Horses; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Neuroblastoma; Piperazines; Structure-Activity Relationship; Tacrine | 2024 |