tacrine has been researched along with bis(7)-tacrine in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 15 (55.56) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Carlier, PR; Du, DM; Han, Y; Liu, J; Pang, YP | 1 |
| Carlier, PR; Chow, ES; El Yazal, J; Han, Y; Liu, J; Pang, YP | 1 |
| Campiani, G; Chiasserini, L; Fattorusso, C; Fedorko, JM; Gaeta, A; Pellerano, C; Savini, L; Saxena, A | 1 |
| Hsiao, G; Hu, MK; Wu, LJ; Yen, MH | 1 |
| Campiani, G; Catalanotti, B; Chiasserini, L; Fattorusso, C; Gaeta, A; McKissic, D; Novellino, E; Pellerano, C; Savini, L; Saxena, A | 1 |
| Badia, A; Camps, P; Clos, MV; Formosa, X; Muñoz-Torrero, D; Petrignet, J | 1 |
| Agnusdei, M; Belinskaya, T; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fedorko, JM; Gaeta, A; Gemma, S; Greig, NH; Holloway, HW; Nacci, V; Novellino, E; Persico, M; Savini, L; Saxena, A | 1 |
| Alcaro, S; Anzini, M; Cappelli, A; Gallelli, A; Makovec, F; Manini, M; Mennuni, L; Menziani, MC; Ortuso, F; Vomero, S | 1 |
| Brumshtein, B; Carlier, PR; Greenblatt, HM; Pang, YP; Rydberg, EH; Shaya, D; Silman, I; Sussman, JL; Williams, LD; Wong, DM | 1 |
| Andrisano, V; Bartolini, M; Bolognesi, ML; Cavalli, A; Melchiorre, C; Recanatini, M; Rosini, M; Valgimigli, L | 1 |
| Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A | 1 |
| Lv, W; Xue, Y | 1 |
| Mohamed, T; Rao, PP | 1 |
| Andrisano, V; Bartolini, M; Belluti, F; Bisi, A; Gobbi, S; Mancini, F; Rampa, A; Rizzo, S | 1 |
| Andrisano, V; Badia, A; Bartolini, M; Bidon-Chanal, A; Camps, P; Clos, MV; Formosa, X; Galdeano, C; González-Muñoz, GC; Luque, FJ; Mancini, F; Minguillón, C; Muñoz-Torrero, D; Ratia, M; Relat, J; Rodríguez-Franco, MI; Salmona, M; Sola, I; Viayna, E | 1 |
| Chen, J; Huang, L; Li, X; Luo, Z; Mao, F; Zhou, Q | 1 |
| Golzmann, A; Holzgrabe, U; Kucharski, A; Ngwa, CJ; Pradel, G; Schirmeister, T; Schmidt, I; Sologub, L | 1 |
| Borges, ACA; Câmara, VS; Campo, LF; Ceschi, MA; da Costa, JS; Dardenne, LE; de Souza, DF; Gonçalves, CAS; Guedes, IA; Karl, ALM; Konrath, EL; Lopes, JPB | 1 |
| Bruhn, H; Fuß, A; Göllner, S; Holzgrabe, U; Katzowitsch, E; Krauth-Siegel, RL; Kucharski, A; Miliu, A; Schirmeister, T; Schmidt, I; Stich, A | 1 |
| Alejandre-Ramos, D; Bartolini, M; Bolognesi, ML; Fernández-Bolaños, JG; Lagunes, I; López, Ó; Maya, I; Monti, B; Padrón, JM; Peña-Altamira, LE; Roldán-Peña, JM | 1 |
| Andrisano, V; Apperley, KYP; Bartolini, M; Baschieri, A; Basso, M; Chen, HH; De Simone, A; Guardigni, M; Keillor, JW; Kobrlova, T; Milelli, A; Montanari, S; Soukup, O; Valgimigli, L | 1 |
| Barocelli, E; Bock, A; Chirinda, B; Dallanoce, C; De Amici, M; Decker, M; Flammini, L; Holzgrabe, U; Irmen, M; Matera, C; Messerer, R; Sotriffer, C; Tränkle, C; Wehle, S | 1 |
| Alvim Guedes, I; Antonio Ceschi, M; da Costa Franarin, G; de Salles, CMC; Emmanuel Dardenne, L; Ferreira Dantas, R; Lopes, JPB; Paes Silva-Jr, F; Roberto Senger, M; Seibert Lüdtke, D; Silva, L | 1 |
| Kumar, A; Mishra, P; Panda, G | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| Bartolini, M; Bolognesi, ML; Fernández-Bolaños, JG; Franconetti, A; Hicke, J; Lagunes, I; López, Ó; Maya, I; Monti, B; Naldi, M; Padrón, JM; Petralla, S; Poeta, E; Roldán-Peña, JM; Romero-Real, V | 1 |
| Du, C; Du, K; Feng, C; Lv, W; Shen, R; Sun, H; Xi, M | 1 |
1 review(s) available for tacrine and bis(7)-tacrine
| Article | Year |
|---|---|
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Ligands; Neuroprotective Agents | 2019 |
26 other study(ies) available for tacrine and bis(7)-tacrine
| Article | Year |
|---|---|
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Sesquiterpenes; Tacrine | 1999 |
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; In Vitro Techniques; Ligands; Protein Binding; Rats; Structure-Activity Relationship; Tacrine | 1999 |
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Catalytic Domain; Ligands; Tacrine | 2001 |
Homodimeric tacrine congeners as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Dimerization; Humans; In Vitro Techniques; Rats; Structure-Activity Relationship; Tacrine | 2002 |
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Ligands; Models, Molecular; Structure-Activity Relationship; Tacrine | 2003 |
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Aminoquinolines; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Structure-Activity Relationship; Tacrine | 2005 |
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Topics: Acetylcholinesterase; Acridines; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; In Vitro Techniques; Ligands; Models, Molecular; Molecular Probes; Structure-Activity Relationship | 2005 |
Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.
Topics: Acetylcholinesterase; Acridines; Animals; Binding Sites; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Computer Simulation; Humans; In Vitro Techniques; Ligands; Male; Models, Molecular; Molecular Conformation; Piperazines; Quinolines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Structure-Activity Relationship; Thermodynamics | 2005 |
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Topics: Acetylcholinesterase; Alkenes; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Dimerization; Models, Molecular; Molecular Structure; Protein Conformation; Tacrine; Torpedo | 2006 |
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Copper; Drug Design; Ferric Compounds; Humans; Ligands; Models, Molecular; Peptide Fragments; Structure-Activity Relationship; Tacrine; Thermodynamics | 2007 |
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine | 2008 |
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.
Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Computational Biology; Drug Design; Models, Chemical; Quantitative Structure-Activity Relationship | 2010 |
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.
Topics: Animals; Catalytic Domain; Cholinesterase Inhibitors; Drug Design; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Models, Molecular; Pyrimidines; Structure-Activity Relationship | 2010 |
Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.
Topics: Alzheimer Disease; Dimerization; Drug Design; Humans; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Tacrine | 2011 |
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Membranes, Artificial; Mice; Models, Molecular; Peptide Fragments; Permeability; Prion Diseases; Prions; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Tacrine | 2012 |
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
Topics: Acetylcholinesterase; Animals; Azoles; Binding Sites; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Free Radical Scavengers; Horses; Humans; Hydrogen Peroxide; Isoindoles; Kinetics; Molecular Docking Simulation; Organoselenium Compounds; Peroxynitrous Acid; Protein Binding; Protein Structure, Tertiary; Tacrine | 2013 |
Bistacrine derivatives as new potent antimalarials.
Topics: Animals; Antimalarials; Carbon-13 Magnetic Resonance Spectroscopy; Dimerization; Inhibitory Concentration 50; Plasmodium; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Tacrine | 2016 |
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.
Topics: Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Electrophorus; Humans; L-Lactate Dehydrogenase; Models, Molecular; S100 Calcium Binding Protein beta Subunit; Tacrine; Thiazepines | 2016 |
Bistacrines as potential antitrypanosomal agents.
Topics: Animals; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Mice; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Tacrine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Chalcogens; Cholinesterase Inhibitors; Dimerization; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; Organoselenium Compounds; Peptide Fragments; Protein Aggregates; Structure-Activity Relationship; Tacrine | 2017 |
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cinnamates; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycogen Synthase Kinase 3 beta; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2017 |
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M
Topics: | 2017 |
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Galactose; Humans; Mice; Molecular Docking Simulation; Ribose; Structure-Activity Relationship; Tacrine; Torpedo; Xylose | 2018 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antineoplastic Agents; Butyrylcholinesterase; Cell Proliferation; Cholinesterase Inhibitors; Dimerization; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Electrophorus; Horses; Humans; Ligands; Models, Molecular; Molecular Structure; Neuroprotective Agents; Phenols; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured | 2019 |
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2022 |