Compounds > tacrine

tacrine and benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide

tacrine has been researched along with benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's7 (70.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS1
Agnusdei, M; Belinskaya, T; Borriello, M; Brindisi, M; Butini, S; Campiani, G; Catalanotti, B; Fattorusso, C; Fiorini, I; Gemma, S; Nacci, V; Novellino, E; Panico, A; Persico, M; Ros, S; Saxena, A1
Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M1
de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M1
Alonso-Gil, S; Conde, S; López, MG; López-Iglesias, B; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI; Romero, A; Villarroya, M1
Glick, D; Gluzman, N; Loewenstein-Lichtenstein, Y; Soreq, H; Sternfeld, M; Zakut, H1
Ariel, N; Barak, D; Kaplan, D; Kronman, C; Ordentlich, A; Shafferman, A; Velan, B1
Ivorra, I; Morales, A; Olivera-Bravo, S1
Ashani, Y; Konstantinovskii, L; Roth, E; Shnyrov, VL; Silman, I; Weiner, L1
Boopathy, R; Chitra, L; Layer, PG; Rajesh, RV1

Other Studies

10 other study(ies) available for tacrine and benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide

ArticleYear
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
    Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7

    Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo

2006
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computational Biology; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tacrine

2008
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
    Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding

2009
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship

2010
New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
    Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9

    Topics: Alzheimer Disease; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Melatonin; Neuroprotective Agents; Spectrometry, Mass, Electrospray Ionization

2014
Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis.
    Molecular pharmacology, 1996, Volume: 50, Issue:6

    Topics: Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Mutagenesis, Site-Directed; Substrate Specificity; Tacrine; Xenopus laevis

1996
Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
    Biochemistry, 2001, Jun-26, Volume: 40, Issue:25

    Topics: Acetylcholinesterase; Amino Acid Substitution; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Binding Sites; Butyrates; Butyrylcholinesterase; Cholinesterase Inhibitors; Decamethonium Compounds; Edrophonium; Humans; Hydrolysis; Kinetics; Ligands; Molecular Mimicry; Mutagenesis, Site-Directed; Organophosphorus Compounds; Substrate Specificity; Tacrine

2001
The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane.
    British journal of pharmacology, 2005, Volume: 144, Issue:1

    Topics: Acetylcholine; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Carbachol; Cell Membrane; Cholinergic Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Conductivity; Female; Inhibitory Concentration 50; Kinetics; Membrane Proteins; Microinjections; Molecular Structure; Neurotransmitter Agents; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Receptors, Muscarinic; Receptors, Nicotinic; Tacrine; Torpedo; Xenopus

2005
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors.
    Biochemistry, 2009, Jan-27, Volume: 48, Issue:3

    Topics: Acetylcholinesterase; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Calorimetry; Cholinesterase Inhibitors; Decamethonium Compounds; Disulfides; Elapid Venoms; Entropy; Enzyme Activation; Enzyme Stability; Guanidine; Humans; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Spin Labels; Tacrine; Temperature; Torpedo

2009
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain.
    Biochimie, 2009, Volume: 91, Issue:9

    Topics: Acetylcholinesterase; Amidohydrolases; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Brain; Chick Embryo; Chickens; Cholinesterase Inhibitors; Donepezil; Enzyme Activation; Esterases; In Vitro Techniques; Indans; Isoflurophate; Piperidines; Tacrine

2009