tacrine has been researched along with amyloid beta-peptides in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farlow, MR; Lahiri, DK; Sambamurti, K | 1 |
| Basun, H; Eckman, C; Lannfelt, L; Nilsberth, C; Younkin, S | 1 |
| Andrisano, V; Bartolini, M; Bolognesi, ML; Cavalli, A; Melchiorre, C; Recanatini, M; Rosini, M; Valgimigli, L | 1 |
| Chen, Y; Lehmann, J; Liao, H; Peng, S; Sun, J; Zhang, Y | 1 |
| Jiang, N; Kong, LY; Li, SY; Wang, KD; Wang, XB; Xie, SS | 1 |
| Cui, W; Han, YF; Hu, SQ; Hu, YJ; Lee, MY; Li, G; Mak, SH; Pang, YP; Wang, R | 1 |
| Carija, A; Muñoz-Torrero, D; Navarro, S; Ventura, S | 1 |
| Belfaitah, A; Bouraiou, A; Chioua, M; García-Font, N; Hayour, H; Iriepa, I; Marco-Contelles, J; Moraleda, I; Oset-Gasque, MJ; Pedraz, J | 1 |
| Edraki, N; Miri, R; Nadri, H; Riazimontazer, E; Sadeghpour, H; Sakhteman, A; Tüylü Küçükkılınç, T | 1 |
1 trial(s) available for tacrine and amyloid beta-peptides
| Article | Year |
|---|---|
Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Male; Peptide Fragments; Tacrine | 2002 |
8 other study(ies) available for tacrine and amyloid beta-peptides
| Article | Year |
|---|---|
The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Biological Transport; Culture Media, Conditioned; Endopeptidases; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Neurons; Peptide Fragments; Protein Processing, Post-Translational; Solubility; Tacrine; Tumor Cells, Cultured | 1998 |
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Copper; Drug Design; Ferric Compounds; Humans; Ligands; Models, Molecular; Peptide Fragments; Structure-Activity Relationship; Tacrine; Thermodynamics | 2007 |
Tacrine-flurbiprofen hybrids as multifunctional drug candidates for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Catalytic Domain; Cells, Cultured; Cholinesterase Inhibitors; Female; Flurbiprofen; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Conformation; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine | 2013 |
Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthraquinones; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Kinetics; Liver; Metals; Mice; Molecular Docking Simulation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Tacrine | 2014 |
Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Peptide Fragments; Rats, Sprague-Dawley; Reactive Oxygen Species; Tacrine | 2015 |
A fast and specific method to screen for intracellular amyloid inhibitors using bacterial model systems.
Topics: Amyloid; Amyloid beta-Peptides; Cost-Benefit Analysis; Drug Evaluation, Preclinical; Escherichia coli; Inclusion Bodies; Intracellular Space; Peptide Fragments; Protein Aggregates; Tacrine; Time Factors | 2016 |
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Drug Design; Electrophorus; Hep G2 Cells; Humans; Neuroprotective Agents; Oligomycins; Oxidative Stress; Peptide Fragments; Phosphorylation; Protein Aggregates; Rotenone; Tacrine; tau Proteins | 2016 |
Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Humans; Isatin; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Aggregates; Schiff Bases; Structure-Activity Relationship; Tacrine | 2019 |