tacrine has been researched along with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 18 (66.67) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Andrisano, V; Bartolini, M; Bolognesi, ML; Cavalli, A; Ceccarini, L; McClymont, DW; Melchiorre, C; Mellor, IR; Minarini, A; Pascu, N; Rosini, M; Simoni, E; Tarozzi, A; Tumiatti, V | 1 |
| Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 2 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Cao, H; Chen, JG; Guan, XL; Guo, XJ; Jiang, FC; Li, L; Wang, CM; Wang, F; Wang, Y; Wu, PF; Xie, N | 1 |
| Chioua, M; del Pino, J; García-Font, N; González, MP; Hadjipavlou-Litina, D; Marco-Contelles, J; Oset-Gasque, MJ; Pérez-Peña, J; Raghuvanshi, DS; Ramos, E; Romero, A; Samadi, A; Singh, KN; Soriano, E | 1 |
| Boonyarat, C; Reubroycharoen, P; Thiratmatrakul, S; Tohda, M; Vajragupta, O; Waiwut, P; Yenjai, C | 1 |
| Arce, MP; Conde, S; González-Muñoz, GC; López, MG; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Dong, G; Guo, PP; Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, XB; Xie, SS | 1 |
| Andrs, M; Babkova, K; Bukum, N; Dolezal, R; Horova, A; Hrabinova, M; Jost, P; Jun, D; Kassa, J; Korabecny, J; Kuca, K; Malinak, D; Muckova, L; Nepovimova, E; Ondrejicek, A; Sepsova, V; Soukup, O | 1 |
| Amooru, GD; Ampasala, DR; Darla, MM; Devineni, SR; Eadlapalli, S; Kotapati, KV; Palaka, BK; Penumala, M; Shaik, JB; Vadde, R | 1 |
| Kong, LY; Li, F; Li, XM; Wang, J; Wang, XB; Wang, ZM; Wu, JJ | 1 |
| Bartolini, M; Bolognesi, ML; Guidotti, L; Hrabinova, M; Jeřábek, J; Korábečný, J; Kuča, K; Monti, B; Peña-Altamira, LE; Petralla, S; Roberti, M; Sepsova, V; Soukup, O; Uliassi, E | 1 |
| Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL | 1 |
| Bachurin, SO; Boltneva, NP; Burgart, YV; Chupakhin, ON; Kovaleva, NV; Lushchekina, SV; Makhaeva, GF; Richardson, RJ; Rudakova, EV; Saloutin, VI; Serebryakova, OG; Shchegol'kov, EV | 1 |
| Bachurin, SO; Boltneva, NP; Charushin, VN; Chupakhin, ON; Lushchekina, SV; Makhaeva, GF; Richardson, RJ; Rudakova, EV; Serebryakova, OG; Shchepochkin, AV; Ustyugov, AA | 1 |
| Feng, X; Hong, G; Li, G; Li, X; Liu, T; Mao, L; Xu, Z; Zhang, Y | 1 |
| Brazzolotto, X; Colletier, JP; Coquelle, N; Gobec, S; Jukič, M; Knez, D; Kos, J; Mravljak, J; Nachon, F; Pišlar, A; Sova, M; Žakelj, S | 1 |
| Beloglazkin, AA; Boltneva, NP; Borisov, RS; Kulikova, LN; Lushchekina, SV; Makhaeva, GF; Richardson, RJ; Rudakova, EV; Serebryakova, OG | 1 |
| Kay, G; Kong Thoo Lin, P; Megson, IL; Scipioni, M | 1 |
| Gobec, S; Godyń, J; Jończyk, J; Knez, D; Malawska, B; Panek, D; Pasieka, A; Sabaté, R; Valdivieso, ÁDR; Wichur, T; Więckowska, A; Więckowski, K | 1 |
| Benek, O; Benkova, M; Dolezal, R; Hepnarova, V; Hrabinova, M; Janockova, J; Jun, D; Kobrlova, T; Korabecny, J; Kucera, T; Mezeiova, E; Prchal, L; Sobolova, K; Soukup, O | 1 |
| Andrisano, V; Aso, E; Bartolini, M; Brea, J; Ciruela, F; De Simone, A; Espargaró, A; Ferrer, I; Garrido, M; Ginex, T; Loza, MI; Luque, FJ; Messeguer, A; Muñoz-Torrero, D; Pallàs, M; Pérez, B; Pérez-Areales, FJ; Puigoriol-Illamola, D; Sabate, R | 1 |
| Fang, L; Gou, S; Liu, Z; Xia, S; Zhang, B | 1 |
| Kumar, S; Mishra, S; Modi, G; Rai, H; Singh, G; Singh, GK; Singh, YP; Srikrishna, S | 1 |
| Amoroso, R; Carradori, S; De Filippis, B; Fantacuzzi, M | 1 |
| Decker, M; Fang, L; Heilmann, J; Kraus, B; Lehmann, J; Zhang, Y | 1 |
2 review(s) available for tacrine and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
| Article | Year |
|---|---|
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Coumaric Acids; Humans; Neuroprotective Agents; Oxidative Stress; Protein Multimerization | 2021 |
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.
Topics: Humans; Neurodegenerative Diseases; Polyphenols; Resveratrol; Stilbenes; Structure-Activity Relationship | 2022 |
25 other study(ies) available for tacrine and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
| Article | Year |
|---|---|
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Models, Molecular; Molecular Structure; Protein Binding; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2008 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding | 2009 |
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
Topics: Humans; Molecular Structure; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phenothiazines; Stereoisomerism; Thiazepines | 2010 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.
Topics: Acetylcholinesterase; Aging; Animals; Butyrylcholinesterase; CA1 Region, Hippocampal; Cell Line, Tumor; Cholinesterase Inhibitors; Humans; Liver; Long-Term Potentiation; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Tacrine | 2012 |
Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's
Topics: Alzheimer Disease; Antioxidants; Cell Line, Tumor; Cholinesterase Inhibitors; Humans; Models, Molecular; Neuroprotective Agents; Stereoisomerism; Tacrine | 2014 |
Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butyrylcholinesterase; Carbazoles; Cell Line; Cholinesterase Inhibitors; Electrophorus; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Oxidative Stress; Tacrine | 2014 |
Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.
Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Humans; Mitochondria; Molecular Structure; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Thiazepines | 2014 |
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
Topics: Alzheimer Disease; Animals; Antioxidants; Biphenyl Compounds; Blood-Brain Barrier; Cell Survival; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Chromans; Drug Design; In Vitro Techniques; Kinetics; Male; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; PC12 Cells; Picrates; Rats; Swine; Tacrine | 2015 |
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Topics: Acetylcholinesterase; Animals; Antioxidants; Blood-Brain Barrier; Catalysis; Cholinesterase Inhibitors; Chromans; Drug Design; Free Radical Scavengers; Hepatocytes; Humans; Injections, Intramuscular; Kinetics; Ligands; Male; Microsomes, Liver; Models, Molecular; Rats; Rats, Wistar; Tacrine | 2015 |
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Binding Sites; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Computer Simulation; Coumarins; Drug Evaluation, Preclinical; Galantamine; Humans; Hydrogen Peroxide; Male; Mice, Inbred BALB C; Models, Molecular; Neuroprotective Agents; Neurotoxicity Syndromes | 2016 |
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Iron; Kinetics; Melatonin; Molecular Docking Simulation; Peptide Fragments; Piperidines; Protein Multimerization; Rats; Zinc | 2016 |
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Liver; Molecular Targeted Therapy; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Resveratrol; Stilbenes; Tacrine | 2017 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species | 2017 |
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
Topics: Animals; Carboxylesterase; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Structure-Activity Relationship; Triazines | 2017 |
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Antioxidants; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Horses; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2017 |
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cholinesterase Inhibitors; Humans; Hydroxybenzoates; Models, Molecular; PC12 Cells; Pyrazines; Rats; Tacrine | 2018 |
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; Caco-2 Cells; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Models, Molecular; Neuroprotective Agents; Piperidines | 2018 |
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromones; Humans; Kinetics; Molecular Docking Simulation; Protein Structure, Tertiary; Structure-Activity Relationship | 2018 |
Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease.
Topics: | 2019 |
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Fluorescence Recovery After Photobleaching; Horses; Humans; Molecular Structure; Protein Aggregates; Pyrrolidines; Structure-Activity Relationship; Sulfonic Acids | 2020 |
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.
Topics: Berberine; Blood-Brain Barrier; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Prolyl Oligopeptidases | 2020 |
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Topics: Alzheimer Disease; Animals; Antioxidants; Benzopyrans; Brain; Humans; Mice; Molecular Dynamics Simulation; Molecular Targeted Therapy; Oxidative Stress; Permeability; Protein Conformation | 2020 |
ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Boronic Acids; Cells, Cultured; Cholinesterase Inhibitors; Cytokines; Dose-Response Relationship, Drug; Humans; Ibuprofen; Lipopolysaccharides; Mice; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Prodrugs; Reactive Oxygen Species; Structure-Activity Relationship; Tacrine | 2021 |
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromans; Coumaric Acids; Drug Design; Humans; Models, Chemical; Reactive Oxygen Species; Structure-Activity Relationship; Tacrine | 2008 |