tacrine has been researched along with 6-chlorotacrine in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 13 (56.52) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Barbe, J; Bonse, S; Krauth-Siegel, RL; Santelli-Rouvier, C | 1 |
| Andrisano, V; Bartolini, M; Belluti, F; Bisi, A; Cavalli, A; Cavrini, V; Gobbi, S; Piazzi, L; Rampa, A; Recanatini, M; Valenti, P | 1 |
| Gago, F; Luque, FJ; Martín-Santamaría, S; Muñoz-Muriedas, J | 1 |
| Lv, W; Xue, Y | 1 |
| Andrisano, V; Badia, A; Bartolini, M; Bidon-Chanal, A; Camps, P; Clos, MV; Formosa, X; Galdeano, C; González-Muñoz, GC; Luque, FJ; Mancini, F; Minguillón, C; Muñoz-Torrero, D; Ratia, M; Relat, J; Rodríguez-Franco, MI; Salmona, M; Sola, I; Viayna, E | 1 |
| Andrisano, V; Bartolini, M; Bergamini, C; Bolognesi, ML; Fato, R; Garcia, GE; Korabecny, J; Kuca, K; Lamba, D; Monti, B; Nepovimova, E; Peña-Altamira, LE; Pesaresi, A; Roberti, M; Samez, S; Uliassi, E | 1 |
| Andrs, M; Babkova, K; Bukum, N; Dolezal, R; Horova, A; Hrabinova, M; Jost, P; Jun, D; Kassa, J; Korabecny, J; Kuca, K; Malinak, D; Muckova, L; Nepovimova, E; Ondrejicek, A; Sepsova, V; Soukup, O | 1 |
| Bartolini, M; Bolognesi, ML; Guidotti, L; Hrabinova, M; Jeřábek, J; Korábečný, J; Kuča, K; Monti, B; Peña-Altamira, LE; Petralla, S; Roberti, M; Sepsova, V; Soukup, O; Uliassi, E | 1 |
| Bruhn, H; Fuß, A; Göllner, S; Holzgrabe, U; Katzowitsch, E; Krauth-Siegel, RL; Kucharski, A; Miliu, A; Schirmeister, T; Schmidt, I; Stich, A | 1 |
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Kumar, A; Mishra, P; Panda, G | 1 |
| Bartolini, M; Benkova, M; Bolognesi, ML; Brazzolotto, X; Caliandro, R; Chalupova, K; Chvojkova, M; Dolezal, R; Gastellier, AJ; Habartova, L; Hepnarova, V; Hrabinova, M; Jarosova, M; Jost, P; Jun, D; Kleteckova, L; Korabecny, J; Kristofikova, Z; Kuca, K; Lamba, D; Mezeiova, E; Misik, J; Monti, B; Muckova, L; Mzik, M; Nachon, F; Nepovimova, E; Pejchal, J; Pesaresi, A; Setnicka, V; Soukup, O; Uliassi, E; Vales, K; Valis, M; Zdarova Karasova, J | 1 |
| do Carmo Carreiras, M; Ismaili, L; Marco-Contelles, J | 1 |
| Andrisano, V; Aso, E; Bartolini, M; Brea, J; Ciruela, F; De Simone, A; Espargaró, A; Ferrer, I; Garrido, M; Ginex, T; Loza, MI; Luque, FJ; Messeguer, A; Muñoz-Torrero, D; Pallàs, M; Pérez, B; Pérez-Areales, FJ; Puigoriol-Illamola, D; Sabate, R | 1 |
| Angeloni, C; Bartolini, M; Bergamini, C; Bolognesi, ML; Chantegreil, F; de Camargo Nascente, L; de Melo Viana Teixeira, S; Freschi, M; Hrelia, S; Malaguti, M; Nachon, F; Prchal, L; Rossi, M; Salerno, A; Soares Romeiro, LA; Soukup, O | 1 |
| Chalupova, K; Gorecki, L; Hepnarova, V; Hrabinova, M; Hroudova, J; Janockova, J; Jun, D; Korabecny, J; Kristofikova, Z; Kucera, T; Kunes, J; Mezeiova, E; Muckova, L; Prchal, L; Soukup, O | 1 |
| Antosiewicz, J; Briggs, JM; Gilson, MK; Humblet, C; McCammon, JA; Straatsma, TP; Sussman, JL; Wlodek, ST | 1 |
| de Austria, C; del Monte-Millán, M; Dorronsoro, I; García-Palomero, E; Martínez, A; Medina, M; Muñoz-Ruiz, P; Rubio, L; Usán, P; Valenzuela, R | 1 |
| Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI | 1 |
| Dolezal, R; Hrabinova, M; Janockova, J; Jost, P; Jun, D; Kaping, D; Korabecny, J; Kuca, K; Kucera, T; Mezeiova, E; Muckova, L; Sepsova, V; Soukup, O; Spilovska, K | 1 |
| Kassa, J; Korabecny, J; Misik, J; Nepovimova, E; Pejchal, J; Soukup, O | 1 |
| Chrienova, Z; Hepnarova, V; Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Kobrlova, T; Korabecny, J; Kucera, T; Nepovimova, E; Skrenkova, K; Soukup, O; Vales, K | 1 |
| Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
2 review(s) available for tacrine and 6-chlorotacrine
| Article | Year |
|---|---|
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Ligands; Neuroprotective Agents | 2019 |
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cholinesterases; Humans; Ligands; Monoamine Oxidase; Neuroprotective Agents; Oxidative Stress; Pargyline; Propylamines | 2020 |
21 other study(ies) available for tacrine and 6-chlorotacrine
| Article | Year |
|---|---|
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.
Topics: Acridines; Animals; Enzyme Inhibitors; Kinetics; Magnetic Resonance Spectroscopy; NADH, NADPH Oxidoreductases; Structure-Activity Relationship; Trypanosoma cruzi | 1999 |
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.
Topics: Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors; Erythrocytes; Humans; Models, Chemical; Models, Molecular; Molecular Conformation; Software; Static Electricity; Structure-Activity Relationship; Tacrine | 2000 |
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Inhibitory Concentration 50; Protein Binding; Quantitative Structure-Activity Relationship; Structure-Activity Relationship | 2004 |
Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.
Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Computational Biology; Drug Design; Models, Chemical; Quantitative Structure-Activity Relationship | 2010 |
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Membranes, Artificial; Mice; Models, Molecular; Peptide Fragments; Permeability; Prion Diseases; Prions; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Tacrine | 2012 |
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Targeted Therapy; Neurons; Oxidative Stress; Quinones; Rats, Wistar; Tacrine | 2014 |
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Topics: Acetylcholinesterase; Animals; Antioxidants; Blood-Brain Barrier; Catalysis; Cholinesterase Inhibitors; Chromans; Drug Design; Free Radical Scavengers; Hepatocytes; Humans; Injections, Intramuscular; Kinetics; Ligands; Male; Microsomes, Liver; Models, Molecular; Rats; Rats, Wistar; Tacrine | 2015 |
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Liver; Molecular Targeted Therapy; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Resveratrol; Stilbenes; Tacrine | 2017 |
Bistacrines as potential antitrypanosomal agents.
Topics: Animals; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Mice; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Tacrine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Ligands; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Tryptophan | 2019 |
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Topics: Alzheimer Disease; Animals; Antioxidants; Benzopyrans; Brain; Humans; Mice; Molecular Dynamics Simulation; Molecular Targeted Therapy; Oxidative Stress; Permeability; Protein Conformation | 2020 |
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anacardium; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cell Line; Cell Survival; Cytokines; Drug Design; Humans; Ligands; Lipopolysaccharides; Microglia; Molecular Dynamics Simulation; Neuroprotective Agents; Nuts; Plant Extracts; Structure-Activity Relationship; Tacrine | 2021 |
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Tryptophan | 2021 |
Binding of tacrine and 6-chlorotacrine by acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Models, Chemical; Molecular Structure; Protein Binding; Tacrine; Thermodynamics; Torpedo | 1996 |
Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Kinetics; Tacrine | 2006 |
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine | 2009 |
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Enzyme Activation; Glucuronates; Humans; Molecular Docking Simulation; Structure-Activity Relationship; Tacrine | 2017 |
Cholinesterase Inhibitor 6-Chlorotacrine - In Vivo Toxicological Profile and Behavioural Effects.
Topics: Animals; Avoidance Learning; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Male; Maze Learning; Mice, Inbred BALB C; Nootropic Agents; Rats, Wistar; Tacrine | 2018 |
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Capillary Permeability; Cell Survival; CHO Cells; Cholinesterase Inhibitors; Cricetulus; Glutamic Acid; HEK293 Cells; Humans; Ligands; Male; Memantine; Molecular Docking Simulation; Neuroprotective Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tacrine; Tissue Culture Techniques | 2019 |
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine | 2019 |