t-0070907 has been researched along with acetyl-isothiocyanate* in 1 studies
1 other study(ies) available for t-0070907 and acetyl-isothiocyanate
| Article | Year |
|---|---|
Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation.
Clinical microtubule-targeting drugs are functionally divided into microtubule-destabilizing and microtubule-stabilizing agents. Drugs from both classes achieve microtubule inhibition by binding different sites on tubulin and inhibiting or promoting polymerization with no concomitant effects on the protein levels of tubulin heterodimers. Here, we have identified a series of small molecules with diverse structures potentially representing a third class of novel tubulin inhibitors that promote degradation by covalent binding to Cys-239 of β-tubulin. The small molecules highlighted in this study include T0070907 (a peroxisome proliferator-activated receptor γ inhibitor), T007-1 (a T0070907 derivative), T138067, Topics: Benzamides; Cysteine; HCT116 Cells; HeLa Cells; Humans; Isothiocyanates; Protein Isoforms; Protein Multimerization; Proteolysis; Pyridines; Sulfonamides; Tubulin | 2019 |