swertiamarin has been researched along with itopride* in 1 studies
1 other study(ies) available for swertiamarin and itopride
| Article | Year |
|---|---|
Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice.
The Swertia japonica is used clinically as a remedy for gastrointestinal symptoms in Japan. We examined the effects of a S. japonica and swertiamarin on gastric emptying and gastrointestinal motility in atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice. All three preparations inhibited reductions in gastric emptying and gastrointestinal motility induced by dopamine (1mg/kg, intraperitoneal injection, ip). Neither the powder, swertiamarin, nor itopride had any effect on the reductions in gastric emptying and gastrointestinal motility caused by 5-HT (4 mg/kg, ip). These findings suggest that the powder and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D(2) receptor. Topics: Animals; Atropine; Benzamides; Benzyl Compounds; Disease Models, Animal; Dopamine; Gastric Emptying; Gastrointestinal Motility; Iridoid Glucosides; Japan; Male; Medicine, East Asian Traditional; Mice; Mice, Inbred ICR; Plant Extracts; Plants, Medicinal; Pyrones; Serotonin; Swertia | 2011 |