sulotroban has been researched along with thromboxane a2 in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (40.00) | 18.7374 |
| 1990's | 27 (54.00) | 18.2507 |
| 2000's | 3 (6.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giessler, C; Mentz, G; Mentz, P; Mest, HJ | 1 |
| Amerini, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Boschetti, E; Gresele, P; Migliacci, R; Nenci, GG; Vezza, R; Volpato, R | 1 |
| Ernst, A; Mest, HJ; Syka, J | 1 |
| Nigam, S; Zakrzewicz, A | 1 |
| Ercan, ZS; Sindel, S; Türker, R | 1 |
| Higo, K; Karasawa, A; Kubo, K; Shirakura, S | 1 |
| Karasawa, A; Kubo, K; Shirakura, S | 1 |
| De Clerck, F; Hemans, C; Van Ammel, K; Van de Water, A; Vandeplassche, G; Wouters, L; Xhonneux, R | 1 |
| Brüne, B; Ullrich, V | 1 |
| Higo, K; Karasawa, A; Kawakage, M; Kubo, K; Obase, H; Ohshima, E; Shirakura, S | 1 |
| Hamid-Bloomfield, S; Payne, AN; Petrovic, AA; Whittle, BJ | 1 |
| Ezumi, K; Narisada, M; Yamakawa, M | 1 |
| Battistini, B; Filep, JG; Sirois, P | 1 |
| Hauser, A; Heinroth-Hoffmann, I; Mest, HJ | 1 |
| Battistini, B; Filep, J; Sirois, P | 1 |
| de Chaffoy de Courcelles, D; De Clerck, F | 1 |
| McGiff, JC; Nasjletti, A; Quilley, J | 1 |
| Horohonich, S; Kopaciewicz, LJ; Kopia, GA; Ohlstein, EH; Shebuski, RJ; Storer, BL | 1 |
| Patscheke, H; Zehender, H | 1 |
| Fujita, T; Hasan, S; Shebuski, RJ; Storer, BL | 1 |
| Ciabattoni, G; Cinotti, GA; Feriozzi, S; Mavrikakis, G; Patrignani, P; Patrono, C; Pecci, G; Pierucci, A; Simonetti, BM | 1 |
| Arnout, J; Bounameaux, H; Deckmyn, H; Gresele, P; Perez-Requejo, JL; Vermylen, J | 1 |
| Arita, H; Hanasaki, K; Nakano, T | 1 |
| Patscheke, H; Witte, EC; Wolff, HP; Zehender, H | 1 |
| Bleifeld, W; Hamm, CW; Kupper, W; Terres, W | 1 |
| Brezinski, ME; Darius, H; Lefer, AM; Yanagisawa, A | 1 |
| Endele, R; Kaufmann, B; Neugebauer, G; Patscheke, H; Staiger, C; Stegmeier, K; Strein, K | 1 |
| Schrör, K; Thiemermann, C | 1 |
| Bugelski, PJ; Granett, JR; Shebuski, RJ; Smith, JM; Storer, BL | 1 |
| Ceuppens, JL; Deckmyn, H; Vermylen, J; Vertessen, S | 1 |
| Patscheke, H; Stegmeier, K | 2 |
| Ageel, AM; Parmar, NS; Tariq, M | 1 |
| Bell, M; Eliasen, K; Hüttemeier, P; Mogensen, T; Qvist, J; Sørensen, JN | 1 |
| Ernst, C; Neuhof, H; Roka, L; Seeger, W; Walmrath, D | 1 |
| Müller-Beckmann, B; Patscheke, H; Pill, J; Schmidt, FH; Stegmeier, K; Witte, EC; Wolff, HP | 1 |
| Bass, T; Bove, AA; Deutsch, E; Goldberg, S; Macdonald, RG; Margolis, JR; Savage, MP; Taussig, A; Vetrovec, G; Whitworth, HB | 1 |
| Brüne, B; Ullrich, V; von Appen, F | 1 |
| Harakawa, H; Ishii, A; Ishii, H; Miki, I; Obase, H; Ohmori, K; Ohshima, E; Sasaki, Y; Sato, H; Takami, H | 1 |
| oude Egbrink, MG; Reneman, RS; Slaaf, DW; Tangelder, GJ | 1 |
| Etoh, S; Hashimoto, O; Kaizu, K; Komine, N; Uriu, K | 1 |
| Becker, K; Bigl, H; Braquet, P; Förster, W; Lueddeckens, G; Sperling, J | 1 |
| Heptinstall, S; Lösche, W; Sanderson, HM; Vickers, J | 1 |
| Dieter, JP; Komiotis, D; Le Breton, GC; Lim, CT; Wencel-Drake, JD | 1 |
| Somova, L | 1 |
| Asai, F; Koike, H; Ogawa, T; Sugidachi, A | 1 |
| David, JL; de Leval, X; Delarge, J; Dogné, JM; Masereel, B | 1 |
| Kudoh, A; Matsuki, A | 1 |
| Fu, LW; Longhurst, JC; Phan, A | 1 |
1 review(s) available for sulotroban and thromboxane a2
| Article | Year |
|---|---|
New trends in thromboxane and prostacyclin modulators.
Topics: Enzyme Inhibitors; Epoprostenol; Fibrinolytic Agents; Humans; Imidazoles; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase | 2000 |
4 trial(s) available for sulotroban and thromboxane a2
| Article | Year |
|---|---|
Thromboxane does not play a significant role in acute, cold-induced vasoconstriction in Raynaud's phenomenon. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.
Topics: Acute Disease; Adolescent; Adult; Cold Temperature; Double-Blind Method; Female; Fingers; Humans; Imidazoles; Male; Middle Aged; Prospective Studies; Raynaud Disease; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction | 1992 |
Improvement of renal function with selective thromboxane antagonism in lupus nephritis.
Topics: Adolescent; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Kidney; Lupus Nephritis; Male; Middle Aged; Random Allocation; Renal Circulation; Sulfonamides; Thromboxane A2 | 1989 |
Thromboxane A2 and prostacyclin do not modulate the systemic hemodynamic response to cold in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; beta-Thromboglobulin; Blood Pressure; Cold Temperature; Double-Blind Method; Epoprostenol; Fingers; Humans; Imidazoles; Indomethacin; Male; Platelet Aggregation; Regional Blood Flow; Sulfonamides; Thromboxane A2; Thromboxane B2; Vascular Resistance; Vasoconstriction | 1985 |
Effect of thromboxane A2 blockade on clinical outcome and restenosis after successful coronary angioplasty. Multi-Hospital Eastern Atlantic Restenosis Trial (M-HEART II)
Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Angiography; Coronary Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Sulfonamides; Thromboxane A2; Time Factors; Treatment Outcome | 1995 |
45 other study(ies) available for sulotroban and thromboxane a2
| Article | Year |
|---|---|
Interactions of prostanoids with the platelet activating factors.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Guinea Pigs; Heart; Iloprost; In Vitro Techniques; Indomethacin; Myocardial Contraction; Perfusion; Platelet Activating Factor; Prostaglandins; Sulfonamides; Thromboxane A2; Thromboxane B2; Triazoles | 1992 |
Effects of thromboxane agonists on cardiac adrenergic neurotransmission.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Sympathetic Nervous System; Synaptic Transmission; Thromboxane A2; Thromboxane B2 | 1992 |
Electrophysiological responses of the cochlea to transient asphyxia are influenced by arachidonate metabolites.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Cochlear Diseases; Epoprostenol; Female; Guinea Pigs; Imidazoles; Male; Phenylacetates; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Time Factors | 1992 |
Tumour cell proliferation by thromboxane A2: a receptor-mediated event.
Topics: Animals; Cell Division; Iloprost; Indomethacin; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Tumor Cells, Cultured | 1991 |
Possible thromboxane A2 mediated effect of angiotensin II in the rabbit isolated perfused kidney.
Topics: Angiotensin II; Animals; Female; Imidazoles; In Vitro Techniques; Kidney; Male; Norepinephrine; Perfusion; Rabbits; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Urine | 1991 |
Actions of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)-ethylidene]-6,11- dihydrodibenz[b,e]oxepine-1-carboxylate monohydrate on smooth muscle preparations.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzimidazoles; Benzoxepins; Blood Pressure; Cats; Dogs; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Phenylacetates; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Sulfonamides; Thromboxane A2 | 1991 |
Protective effects of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)-ethylidene]-6,11- dihydrodibenz[b,e]oxepine-2-carboxylate monohydrate against 9,11-dideoxy- 9 alpha, 11 alpha-epoxymethano-prostaglandin F2
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Benzimidazoles; Benzoxepins; Blood Pressure; Death, Sudden; Dose-Response Relationship, Drug; Guinea Pigs; Male; Phenylacetates; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Sulfonamides; Thromboxane A2; Thromboxanes; Ticlopidine | 1991 |
Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine coronary ar
Topics: Animals; Coronary Thrombosis; Coronary Vessels; Dogs; Endothelium, Vascular; Female; Hemodynamics; In Vitro Techniques; Male; Pentanoic Acids; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase | 1991 |
Different calcium pools in human platelets and their role in thromboxane A2 formation.
Topics: Antioxidants; Blood Platelets; Calcium; Calcium-Transporting ATPases; Fibrinolytic Agents; Humans; Hydroquinones; Nigericin; Platelet Activation; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Terpenes; Thapsigargin; Thrombin; Thromboxane A2; Thromboxane B2 | 1991 |
Antiplatelet effects of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)-ethylidene]-6,11- dihydrodibenz[b,e] oxepine-2-carboxylate monohydrate.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adult; Animals; Benzimidazoles; Benzoxepins; Cats; Dogs; Drug Interactions; Epinephrine; Guinea Pigs; Humans; In Vitro Techniques; Mice; Middle Aged; Phenylacetates; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Rabbits; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1991 |
The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C.
Topics: Administration, Inhalation; Anesthesia; Animals; Benzeneacetamides; Bronchi; Cyclooxygenase Inhibitors; Guinea Pigs; Hydantoins; Hydroxamic Acids; Indomethacin; Lipoxygenase Inhibitors; Male; Platelet Aggregation Inhibitors; Prostaglandin D2; Prostaglandins D; Receptors, Prostaglandin; Respiratory Function Tests; Sulfonamides; Thromboxane A2; Vagotomy | 1990 |
Computer-aided molecular modeling of a thromboxane receptor antagonist S-145 and its related compounds.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Computer Simulation; Fatty Acids, Monounsaturated; Models, Molecular; Molecular Conformation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thromboxane A2 | 1990 |
Endothelin induces thromboxane release and contraction of isolated guinea-pig airways.
Topics: Animals; Anti-Arrhythmia Agents; Bronchi; Dose-Response Relationship, Drug; Endothelins; Epoprostenol; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Phenylacetates; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxanes; Trachea | 1990 |
Effects of platelet activating factor antagonists on arachidonic acid-induced platelet aggregation and TXA2 formation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Blood Platelets; Diterpenes; Ginkgolides; Imidazoles; In Vitro Techniques; Lactones; Naphthalenes; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Triazoles | 1990 |
Potent thromboxane-mediated in vitro bronchoconstrictor effect of endothelin in the guinea-pig.
Topics: Animals; Bronchi; Endothelins; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Peptides; Sulfonamides; Thromboxane A2; Thromboxanes; Trachea | 1990 |
Effect of thromboxane A2 synthetase inhibition, singly and combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on inositol phospholipid turnover and on 5-HT release by washed human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Collagen; Humans; In Vitro Techniques; Indomethacin; Inositol Phosphates; Methacrylates; Platelet Activating Factor; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Serotonin; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Kidney; Male; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Prostaglandins H; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 1989 |
Combination of the thromboxane receptor antagonist, sulotroban (BM 13.177; SK&F 95587), with streptokinase: demonstration of thrombolytic synergy.
Topics: Animals; Dogs; Drug Synergism; Fibrinolytic Agents; Hemodynamics; Heparin; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Receptors, Prostaglandin; Receptors, Thromboxane; Regional Blood Flow; Streptokinase; Sulfonamides; Thromboxane A2; Thromboxane B2 | 1989 |
Polyvalent TXA2/PGH2 receptor antagonists with very high affinity.
Topics: Blood Platelets; Humans; In Vitro Techniques; Kinetics; Polylysine; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1989 |
Effect of selective endoperoxide/thromboxane A2 receptor antagonism with sulotroban on tPA-induced thrombolysis in a rabbit model of femoral arterial thrombosis.
Topics: Animals; Femoral Artery; Fibrinolytic Agents; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin Endoperoxides; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Recombinant Proteins; Regional Blood Flow; Sulfonamides; Thrombosis; Thromboxane A2; Tissue Plasminogen Activator | 1989 |
Two phasic generation of thromboxane A2 by the action of collagen on rat platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Indomethacin; Kinetics; Phospholipases; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Quinacrine; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1987 |
Irreversible inhibition of the TXA2/PGH2 receptor of human platelets by a photoaffinity ligand.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Affinity Labels; Azides; Blood Platelets; Fibrinolytic Agents; Humans; Kinetics; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1988 |
Resting myocardial ischemia after intravenous infusion of BM 13.177 (sulotroban), a thromboxane receptor antagonist.
Topics: Coronary Circulation; Coronary Disease; Fibrinolytic Agents; Humans; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1987 |
Anti-ischemic actions of a new thromboxane receptor antagonist during acute myocardial ischemia in cats.
Topics: Animals; Blood Pressure; Cats; Coronary Disease; Creatine Kinase; Heart Rate; Myocardium; Pancreas; Platelet Aggregation; Proteins; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1985 |
The pharmacokinetic and pharmacodynamic profiles of the thromboxane A-2 receptor blocker BM 13.177.
Topics: Adult; Blood Platelets; Collagen; Humans; Kidney; Kinetics; Male; Platelet Aggregation; Receptors, Cell Surface; Serotonin; Sulfonamides; Thromboxane A2; Time Factors | 1986 |
Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177).
Topics: Adenosine Triphosphate; Animals; Blood Platelets; Cats; Coronary Disease; Creatine Kinase; Electrocardiography; Fibrinolytic Agents; Heart Rate; Hemodynamics; Myocardium; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Time Factors | 1986 |
Influence of selective endoperoxide/thromboxane A2 receptor antagonism with sulotroban on lysis time and reocclusion rate after tissue plasminogen activator-induced coronary thrombolysis in the dog.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Dogs; Drug Therapy, Combination; Female; Fibrinolytic Agents; Male; Platelet Aggregation Inhibitors; Sulfonamides; Thromboxane A2; Tissue Plasminogen Activator | 1988 |
Effects of thromboxane A2 on lymphocyte proliferation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Antibodies, Monoclonal; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Imidazoles; Indomethacin; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins E; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes | 1985 |
Effects of the prostaglandin H2/thromboxane A2 antagonist BM 13.177 on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Collagen; Humans; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Serotonin; Sulfonamides; Thrombin; Thromboxane A2; Thromboxanes | 1985 |
Effect of thromboxane A2 and leukotriene C4 inhibitors on the experimentally induced gastric lesions in the rat.
Topics: Animals; Anti-Ulcer Agents; Chromones; Female; Fibrinolytic Agents; Male; Methacrylates; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; SRS-A; Stomach Ulcer; Sulfonamides; Thromboxane A2 | 1987 |
Effects of a thromboxane antagonist (BM 13.177) during endotoxin-induced pulmonary vasoconstriction in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Endotoxins; Escherichia coli; Female; Hypertension, Pulmonary; Lung; Sheep; Sulfonamides; Thromboxane A2; Thromboxane B2; Vasoconstriction | 1986 |
Influence of the thromboxane antagonist BM 13.177 on the arachidonic acid-induced increase in pulmonary vascular resistance and permeability in rabbit lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcimycin; Capillary Permeability; Fibrinolytic Agents; In Vitro Techniques; Indomethacin; Kinetics; Pulmonary Circulation; Rabbits; Sulfonamides; Thromboxane A2; Vascular Resistance; Vasoconstriction | 1985 |
The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Epoprostenol; Female; Fibrinolytic Agents; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Sulfonamides; Thrombosis; Thromboxane A2; Thromboxane B2; Thromboxanes | 1984 |
Investigation on a selective non-prostanoic thromboxane antagonist, BM 13.177, in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Epinephrine; Humans; Hydrogen Peroxide; Imidazoles; Indomethacin; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins E; Serotonin; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxanes | 1984 |
Receptor occupancy regulates Ca2+ entry and intracellular Ca2+ redistribution in activated human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Epoprostenol; Humans; Intracellular Fluid; Nitroprusside; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Signal Transduction; Sulfonamides; Terpenes; Thapsigargin; Thromboxane A2 | 1994 |
Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1.
Topics: Animals; Dibenzoxepins; Drug Design; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Structure-Activity Relationship; Sulfonamides; Thromboxane A2 | 1993 |
Different roles of prostaglandins in thromboembolic processes in arterioles and venules in vivo.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arterioles; Aspirin; Epoprostenol; Female; Hydroxyeicosatetraenoic Acids; Leukocytes; Male; Mesentery; Platelet Activation; Prostaglandins; Rabbits; Receptors, Thromboxane; Regional Blood Flow; Sulfonamides; Thromboembolism; Thromboxane A2; Venules; Videotape Recording | 1993 |
Acute and chronic effects of thromboxane A2 inhibition on the renal hemodynamics in streptozotocin-induced diabetic rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Hemodynamics; Kidney; Male; Methacrylates; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Renal Circulation; Streptozocin; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance; Vasoconstriction | 1994 |
Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig.
Topics: Animals; Aspirin; Blood Pressure; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Endothelins; Guinea Pigs; Imidazoles; Male; Naphthalenes; Prostaglandin-Endoperoxide Synthases; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasopressins | 1993 |
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents | 1996 |
Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Biotin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; Microscopy, Fluorescence; Molecular Probes; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Spectrometry, Fluorescence; Sulfonamides; Thromboxane A2 | 1996 |
Prostaglandin H2/thromboxane A2 pathway in platelet aggregation and activity of Dahl salt-sensitive rat--a sulotroban study.
Topics: Animals; Bleeding Time; Blood Pressure; Collagen; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred Strains; Sodium; Sulfonamides; Thromboxane A2 | 1996 |
Involvement of platelet-derived 5-hydroxytryptamine in thromboxane A2-induced aggregation in cat platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Platelets; Cats; Collagen; Cyclooxygenase Inhibitors; Drug Interactions; Female; Indomethacin; Ketanserin; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Serotonin Antagonists; Sulfonamides; Thromboxane A2 | 1998 |
Bradykinin-induced inositol 1,4,5-triphosphate in neonatal rat cardiomyocytes is activated by endotoxin.
Topics: Animals; Animals, Newborn; Bradykinin; Cinnamates; Endotoxins; Gallic Acid; Heart; In Vitro Techniques; Indomethacin; Inositol 1,4,5-Trisphosphate; Kinetics; Lipopolysaccharides; Myocardium; ortho-Aminobenzoates; Rats; Sulfonamides; Thromboxane A2 | 2000 |
Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthetics, Local; Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart; Hemodynamics; Histamine H1 Antagonists; Indoles; Kidney; Male; Myocardial Ischemia; Pressoreceptors; Procaine; Pyrilamine; Receptors, Thromboxane; Reflex; Serotonin Antagonists; Sulfonamides; Sympathetic Nervous System; Thromboxane A2; Tropisetron; Vagotomy | 2008 |