sulfuretin has been researched along with aurone* in 4 studies
4 other study(ies) available for sulfuretin and aurone
| Article | Year |
|---|---|
Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase.
Xanthine oxidase is a potential target for treatment of hyperuricemia and gout. In this study, a number of A- and B-ring carboxylated aurone derivatives were synthesized and evaluated for their ability to inhibit xanthine oxidase in vitro. According to the results obtained, two different ranges of inhibitory activity were observed. The aurones with carboxylic acid group at the 4'-position of B-ring were found to be potent inhibitors of the enzyme with IC Topics: Benzofurans; Binding Sites; Carboxylic Acids; Catalytic Domain; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship; Xanthine Oxidase | 2017 |
Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives.
A series of 6-hydroxyaurones and their analogues have been synthesized and evaluated for their in vitro α-glucosidase inhibitory and glucose consumption-promoting activity. These compounds exhibited varying degrees of α-glucosidase inhibitory activity, 11 of them showing higher potency than that of the control standard acarbose (IC Topics: alpha-Glucosidases; Benzofurans; Glucose; Glycoside Hydrolase Inhibitors; Hep G2 Cells; Humans; Molecular Docking Simulation; Saccharomyces cerevisiae | 2017 |
Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.
Alzheimer's disease (AD), a progressive and neurodegenerative disorder of the brain, is the most common cause of dementia among elderly people. To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (AChE). In the present study, aurone derivatives were designed and synthesized as AChE inhibitors based on the lead structure of sulfuretin. Of those synthesized, compound 10d showed ca. 1700-fold and 6-fold higher AChE inhibitory activity than sulfuretin and galantamine, respectively. This compound also ameliorated scopolamine-induced memory deficit in mice when administered orally at the dose of 1 and 2mg/kg. Topics: Alzheimer Disease; Animals; Benzofurans; Cholinesterase Inhibitors; Male; Mice | 2015 |
Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE(2) production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE(2) production and were less cytotoxic than sulfuretin. Topics: Animals; Anti-Infective Agents; Benzofurans; Cell Line, Tumor; Dinoprostone; Lipopolysaccharides; Mice; Nitric Oxide | 2011 |