sulfoquinovosyl-diglyceride and 1-piperidinocyclohexanecarbonitrile

sulfoquinovosyl-diglyceride has been researched along with 1-piperidinocyclohexanecarbonitrile* in 1 studies

Other Studies

1 other study(ies) available for sulfoquinovosyl-diglyceride and 1-piperidinocyclohexanecarbonitrile

Article	Year
Telomerase inhibitors from cyanobacteria: isolation and synthesis of sulfoquinovosyl diacylglycerols from Microcystis aeruguinosa PCC 7806. Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Apr-02, Volume: 19, Issue:14 By using the Telospot assay, 27 different extracts of cyanobacteria were evaluated for telomerase inhibition. All extracts showed varying, but significant activity. We selected Microcystis aeruguinosa PCC 7806 to identify the active compound and a bioassay guided fractionation led us to isolate mixtures of sulfoquinovosyl diacylglycerols (SQDGs), which were identified by 2D NMR and MS/MS experiments. Pure SQDG derivatives were then synthesized. The IC(50) values of pure synthetic sulfoquinovosyl dipalmitoylglycerol and the monopalmitoylated derivative against telomerase were determined to be 17 and 40 μM, respectively. A structure-activity relationship study allowed the identification of compounds with modified lipophilic acyl groups that display improved activity. Topics: Diglycerides; Enzyme Inhibitors; Glycolipids; Microcystis; Phencyclidine; Structure-Activity Relationship; Tandem Mass Spectrometry; Telomerase	2013

Article

Year

Telomerase inhibitors from cyanobacteria: isolation and synthesis of sulfoquinovosyl diacylglycerols from Microcystis aeruguinosa PCC 7806.

Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Apr-02, Volume: 19, Issue:14

By using the Telospot assay, 27 different extracts of cyanobacteria were evaluated for telomerase inhibition. All extracts showed varying, but significant activity. We selected Microcystis aeruguinosa PCC 7806 to identify the active compound and a bioassay guided fractionation led us to isolate mixtures of sulfoquinovosyl diacylglycerols (SQDGs), which were identified by 2D NMR and MS/MS experiments. Pure SQDG derivatives were then synthesized. The IC(50) values of pure synthetic sulfoquinovosyl dipalmitoylglycerol and the monopalmitoylated derivative against telomerase were determined to be 17 and 40 μM, respectively. A structure-activity relationship study allowed the identification of compounds with modified lipophilic acyl groups that display improved activity.

Topics: Diglycerides; Enzyme Inhibitors; Glycolipids; Microcystis; Phencyclidine; Structure-Activity Relationship; Tandem Mass Spectrometry; Telomerase

2013