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sulfaphenazole and tolbutamide

sulfaphenazole has been researched along with tolbutamide in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199011 (27.50)18.7374
1990's16 (40.00)18.2507
2000's7 (17.50)29.6817
2010's6 (15.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aoyama, R; Jones, JP; Rao, S; Rettie, A; Schrag, M; Trager, WF1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Ekins, S; Harwood, HJ; Hoover, DJ; Lawton, MP; Mankowski, DC; Treadway, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dai, R; Liu, Y; She, M; Wu, Z1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Brown, KF; Crooks, MJ1
Konishi, R; Shibasaki, J; Yamasaki, K1
Birkett, DJ; Pond, SM; Wade, DN1
Birkett, DJ; Doecke, CJ; Mackenzie, PI; McManus, ME; Miners, JO; Veronese, ME1
Birkett, DJ; Doecke, CJ; McManus, ME; Miners, JO; Pond, SM; Sansom, LN; Veronese, ME1
Birkett, DJ; Gregov, D; Miners, JO; Randles, D; Veronese, ME1
Brian, WR; Guengerich, FP; Lloyd, RS; Srivastava, PK; Umbenhauer, DR1
Back, DJ; Mönig, H; Ohnhaus, EE; Park, BK; Tjia, J1
Göres, E; Kiesewetter, R1
Christensen, LK; Kristensen, M1
Hellman, B1
Hanano, M; Iga, T; Sawada, Y; Sugita, O; Sugiyama, Y2
Ayrton, AD; Baldwin, SJ; Bloomer, JC; Chenery, RJ; Clarke, SE; Smith, GJ1
Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K1
Birkett, DJ; Miners, JO; Rees, DL; Valente, L; Veronese, ME1
Birkett, DJ; Doecke, CJ; Gasser, R; Mackenzie, PI; McManus, ME; Meyer, UA; Miners, JO; Rees, DL; Veronese, ME1
Feron, VJ; Groene, EM; Horbach, GJ; Kappers, WA; Kleij, LA; Witkamp, RF; Zweers-Zeilmaker, WM1
Gonzalez, FJ; Korzekwa, KR; Marra, C; Tracy, TS; Wrighton, SA1
Horbach, GJ; Witkamp, RF; Zweers-Zeilmaker, WM1
Shimada, T; Yamazaki, H1
Inoue, K; Kamataki, T; Kodama, T; Nagashima, K; Nakamura, K; Shimada, N; Shimizu, T; Yokoi, T1
Back, DJ; Eagling, VA; Tjia, JF1
Inoue, T; Kuroiwa, Y; Nakajima, M; Shimada, N; Tokudome, S; Yamamoto, T1
Inoue, K; Shimada, T; Yamazaki, H1
Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA1
Ito, K; Kanamitsu, S; Sugiyama, Y1
CHRISTENSEN, LK; HANSEN, JM; KRISTENSEN, M1
Chan, SL; Or, PM; Yeung, JH1
Huang, HH; Lin, LH; Zhang, P; Zhong, DF1
Pickova, J; Vestergren, AS; Zamaratskaia, G; Zlabek, V1
Burmistrova, OA; Poloznikov, AA; Sakharov, DA; Shkurnikov, MY; Zakhariants, AA1
Chappell, J; Kellie Turner, P; Ng, WT; Perkins, EJ; Posada, M; Twelves, C1

Other Studies

40 other study(ies) available for sulfaphenazole and tolbutamide

ArticleYear
A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Ligands; Models, Biological; Models, Molecular; Protein Binding; Reproducibility of Results; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship; Sulfaphenazole; Sulfonamides; Warfarin

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3

    Topics: Amides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Oxidoreductases; Quantitative Structure-Activity Relationship; Sterol 14-Demethylase

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3

    Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Displacement of tolbutamide, glibencalmide and chlorpropamide from serum albumin by anionic drugs.
    Biochemical pharmacology, 1976, May-15, Volume: 25, Issue:10

    Topics: Acetaminophen; Animals; Cattle; Chlorpropamide; Dialysis; Glyburide; Humans; Phenylbutazone; Protein Binding; Salicylates; Serum Albumin; Serum Albumin, Bovine; Sulfaphenazole; Tolbutamide; Warfarin

1976
Tolbutamide-sulfaphenazole interaction in rabbits.
    Journal of pharmacokinetics and biopharmaceutics, 1977, Volume: 5, Issue:3

    Topics: Animals; Drug Interactions; Kinetics; Male; Rabbits; Sulfaphenazole; Tolbutamide

1977
Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:5 Pt 1

    Topics: Adult; Depression, Chemical; Drug Interactions; Half-Life; Humans; Male; Oxyphenbutazone; Phenylbutazone; Sulfaphenazole; Time Factors; Tolbutamide

1977
Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.
    Biochemical and biophysical research communications, 1991, Mar-29, Volume: 175, Issue:3

    Topics: Animals; Base Sequence; Cell Line; Cytochrome P-450 Enzyme System; DNA; Gene Library; Humans; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Molecular Sequence Data; Oligonucleotide Probes; Phenytoin; Recombinant Proteins; Substrate Specificity; Sulfaphenazole; Tolbutamide; Transfection

1991
Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.
    British journal of clinical pharmacology, 1991, Volume: 31, Issue:2

    Topics: Binding, Competitive; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Sulfaphenazole; Tolbutamide

1991
Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:3

    Topics: Administration, Oral; Adult; Chromatography; Female; Half-Life; Humans; Hydroxylation; Male; Phenotype; Random Allocation; Sulfaphenazole; Tolbutamide

1990
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
    Biochemistry, 1989, Jun-13, Volume: 28, Issue:12

    Topics: Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Electrophoresis; Gene Expression Regulation; Genetic Vectors; Hexobarbital; Humans; Liver; Mephenytoin; Mixed Function Oxygenases; Oxidation-Reduction; Plasmids; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Sulfaphenazole; Tolbutamide

1989
Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide.
    European journal of clinical pharmacology, 1988, Volume: 34, Issue:2

    Topics: Adult; Antipyrine; Cimetidine; Female; Half-Life; Humans; Male; Oxidation-Reduction; Pharmaceutical Preparations; Primaquine; Sulfaphenazole; Tolbutamide

1988
[Dangers in drug combinations].
    Zeitschrift fur arztliche Fortbildung, 1972, Feb-15, Volume: 66, Issue:4

    Topics: Dicumarol; Dosage Forms; Drug Antagonism; Drug Interactions; Drug Synergism; Erythroblastosis, Fetal; Female; Humans; Isocarboxazid; Microsomes, Liver; Phenylbutazone; Pregnancy; Sulfaphenazole; Sulfonamides; Tolbutamide

1972
[Drug induced changes of the blood glucose lowering effect of oral hypoglycemic agents].
    Acta diabetologica latina, 1969, Volume: 6 Suppl 1

    Topics: Aged; Blood Glucose; Chlorpropamide; Chromatography, Thin Layer; Dicumarol; Drug Synergism; Humans; Hypoglycemia; Hypoglycemic Agents; Liver; Protein Binding; Sulfaphenazole; Sulfur Isotopes; Tolbutamide

1969
Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells.
    Metabolism: clinical and experimental, 1974, Volume: 23, Issue:9

    Topics: Animals; Binding Sites; Drug Synergism; Female; Glyburide; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Phenylbutazone; Serum Albumin; Sucrose; Sulfaphenazole; Sulfisomidine; Sulfisoxazole; Sulfonamides; Tolbutamide

1974
Effect of sulfaphenazole on tolbutamide distribution in rabbits: analysis of interspecies differences in tissue distribution of tolbutamide.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:5

    Topics: Animals; Male; Rabbits; Rats; Species Specificity; Sulfaphenazole; Tissue Distribution; Tolbutamide

1984
Prediction of drug-drug interaction from in vitro plasma protein binding and metabolism. A study of tolbutamide-sulfonamide interaction in rats.
    Biochemical pharmacology, 1981, Dec-15, Volume: 30, Issue:24

    Topics: Animals; Blood Proteins; Drug Interactions; Half-Life; Male; Mathematics; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Sulfadimethoxine; Sulfamethoxazole; Sulfaphenazole; Sulfonamides; Tolbutamide

1981
Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9.
    Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide

1995
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:4

    Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin

1995
Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diuretics; Humans; In Vitro Techniques; Kinetics; Liver; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Sulfonamides; Tolbutamide; Torsemide

1995
Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily.
    The Biochemical journal, 1993, Jan-15, Volume: 289 ( Pt 2)

    Topics: Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cell Line; Cytochrome P-450 Enzyme System; DNA; Humans; Hydroxylation; Isoenzymes; Kinetics; Liver; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide; Transfection

1993
Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.
    Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Drug Interactions; Enzyme Inhibitors; Flurbiprofen; Gene Expression; Humans; Hydroxylation; Ketoprofen; Lung; Methylation; Mixed Function Oxygenases; Phenylbutazone; Sulfaphenazole; Tolbutamide; Transfection

1996
Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation.
    European journal of clinical pharmacology, 1997, Volume: 52, Issue:4

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dealkylation; Humans; In Vitro Techniques; Microsomes, Liver; Naproxen; Piroxicam; Sulfaphenazole; Tolbutamide; Transfection; Vaccinia virus; Warfarin

1997
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus).
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:8

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Female; Goats; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Phenylbutazone; Phenytoin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Sulfonamides; Tolbutamide

1997
Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers.
    Biochemical pharmacology, 1997, Dec-01, Volume: 54, Issue:11

    Topics: Animals; Anticoagulants; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfaphenazole; Tolbutamide; Warfarin

1997
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: 1-Propanol; Caffeine; Chlorzoxazone; Coumarins; Cyclosporine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Phenothiazines; Precipitin Tests; Sulfaphenazole; Tolbutamide

1998
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
    British journal of clinical pharmacology, 1998, Volume: 45, Issue:2

    Topics: Animals; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Wistar; Substrate Specificity; Sulfaphenazole; Testosterone; Theophylline; Tolbutamide

1998
Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:3

    Topics: Alkylation; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gene Expression Regulation; Humans; Indomethacin; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Oxidoreductases, O-Demethylating; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide; Tumor Cells, Cultured; Warfarin

1998
Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1998, Volume: 28, Issue:2

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Genotype; Humans; Hydroxylation; Japan; Kinetics; Microsomes, Liver; Polymorphism, Genetic; Recombinant Proteins; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide; Warfarin

1998
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
    Journal of periodontal research, 1999, Volume: 34, Issue:3

    Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chromatography, High Pressure Liquid; Epilepsy; Female; Gingival Overgrowth; Humans; Hydroxylation; Liver; Male; Microsomes; Middle Aged; Phenytoin; Photosensitizing Agents; Rats; Rats, Wistar; Species Specificity; Statistics, Nonparametric; Sulfaphenazole; Tolbutamide

1999
Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.
    Pharmaceutical research, 2000, Volume: 17, Issue:3

    Topics: Animals; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypoglycemic Agents; Liver; Models, Biological; Predictive Value of Tests; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Tolbutamide

2000
SULPHAPHENAZOLE-INDUCED HYPOGLYCAEMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS.
    Lancet (London, England), 1963, Dec-21, Volume: 2, Issue:7321

    Topics: Aged; Diabetes Mellitus; Geriatrics; Humans; Hypoglycemia; Hypoglycemic Agents; Phenylbutazone; Sulfadiazine; Sulfadimethoxine; Sulfaphenazole; Tolbutamide

1963
Polysaccharide peptides from COV-1 strain of Coriolus versicolor inhibit tolbutamide 4-hydroxylation in the rat in vitro and in vivo.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2006, Volume: 44, Issue:8

    Topics: Animals; Basidiomycota; Carbohydrate Sequence; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxylation; Hypoglycemic Agents; Isoenzymes; Liver; Male; Microsomes, Liver; Molecular Sequence Data; Proteoglycans; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Tolbutamide

2006
[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:10

    Topics: Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Cunninghamella; Cytochrome P-450 CYP2C9; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Fungal Proteins; Indomethacin; Isoenzymes; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfaphenazole; Tolbutamide; Valproic Acid

2006
Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
    Molecular biology reports, 2012, Volume: 39, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diclofenac; Dioxoles; Ellipticines; Fish Proteins; Fluconazole; Hydroxylation; Ketoconazole; Kinetics; Lignans; Microsomes, Liver; Oxazines; Salmo salar; Sulfaphenazole; Tolbutamide

2012
Development of a Specific Substrate-Inhibitor Panel (Liver-on-a-Chip) for Evaluation of Cytochrome P450 Activity.
    Bulletin of experimental biology and medicine, 2016, Volume: 162, Issue:1

    Topics: Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Ketoconazole; Lab-On-A-Chip Devices; Liver; Mass Spectrometry; Mephenytoin; Microsomes, Liver; Omeprazole; Phencyclidine; Substrate Specificity; Sulfaphenazole; Testosterone; Tolbutamide

2016
Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam.
    European journal of drug metabolism and pharmacokinetics, 2018, Volume: 43, Issue:3

    Topics: Benzamides; Clinical Trials as Topic; Cytochrome P-450 CYP2C9; Drug Interactions; Humans; Models, Biological; Sulfaphenazole; Sulfonamides; Tolbutamide

2018