sulfamethoxazole hydroxylamine and sulfamethoxazole

sulfamethoxazole hydroxylamine has been researched along with sulfamethoxazole in 44 studies

Compound Research Comparison

Studies (sulfamethoxazole hydroxylamine)	Trials (sulfamethoxazole hydroxylamine)	Recent Studies (post-2010) (sulfamethoxazole hydroxylamine)	Studies (sulfamethoxazole)	Trials (sulfamethoxazole)	Recent Studies (post-2010) (sulfamethoxazole)
45	6	7	5,813	680	1,216

Protein Interaction Comparison

Protein	Taxonomy	sulfamethoxazole (IC50)
Dihydropteroate synthase	Escherichia coli K-12	4.7
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	4.7
Dihydrofolate reductase	Pneumocystis carinii	0.1
Endothelin-1 receptor	Rattus norvegicus (Norway rat)	4

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.27)	18.7374
1990's	17 (38.64)	18.2507
2000's	17 (38.64)	29.6817
2010's	8 (18.18)	24.3611
2020's	1 (2.27)	2.80

Authors

Authors	Studies
Ay, M; Çelik, A; Güngör, T; Yetiş, G	1
Almawi, WY; Bird, IA; Rieder, MJ; Sisson, E	1
Cribb, AE; Spielberg, SP	2
Dosch, HM; Leeder, JS; Spielberg, SP	1
Dosch, HM; Leeder, JS; Nakhooda, A; Spielberg, SP	1
Dosch, HM; Leeder, JS; Riley, RJ; Spielberg, SP	1
Cribb, AE; Miller, M; Spielberg, SP; Tesoro, A	1
Dosch, HM; Harper, PA; Lam, P; Leeder, JS; Spielberg, SP	1
Cribb, AE; Griffin, GP; Spielberg, SP	1
Bird, IA; Dekaban, GA; Krause, R; Rieder, MJ	1
Koopmans, PP; Mantel, MA; van der Meer, JW; van der Ven, AJ; Vree, TB	1
Delahunty, T; Lee, BL; Safrin, S	1
Carr, A; Cooper, DA; Penny, R; Tindall, B	1
Kalhorn, TF; Kharasch, ED; Mitra, AK; Slattery, JT; Thummel, KE; Unadkat, JD	1
Almawi, WY; Bird, IA; Hess, DA; Rieder, MJ	1
Almawi, WY; Bird, IA; Rieder, MJ; Sisson, ME	1
Lehmann, DF; Morse, PD; Newman, N	1
Hess, DA; Madrenas, J; Puvanesasingham, R; Rieder, MJ; Sisson, ME; Suria, H; Wijsman, J	1
Naisbitt, DJ; Park, BK; Pirmohamed, M; Stalford, AC; Vilar, FJ; Wilkins, EG	1
Britschgi, M; Burkhart, C; Depta, JP; Naisbitt, DJ; Park, KB; Pichler, WJ; von Greyerz, S	1
Miller, JL; Trepanier, LA	2
Cribb, AE; McQuaid, T; Renton, KW	1
Almawi, WY; Hess, DA; Lee, JT; Madrenas, J; O'Leary, EF; Rieder, MJ	1
Cribb, AE; Summan, M	1
Bajad, S; Beckwith, MD; Bellehumeur, JL; Graziano, FM; Trepanier, LA; Yoder, AR	1
Greenspan, DL; Hooton, TM; Jacobson, M; Slattery, JT; Trapnell, CB; Unadkat, JD; Winter, HR	1
Dearman, RJ; Hopkins, JE; Humphreys, N; Kimber, I; Naisbitt, DJ; Park, BK	1
Dekaban, GA; Rieder, MJ; Wijsman, JA	1
Amschler, J; Behrens, D; Clement, B; Havemeyer, A; Matschke, K; Wolf, S	1
Bedard, K; Breining, T; Cribb, AE; Ryan, PM	1
Bajad, SU; Graziano, FM; Guzinski, MV; Kurian, JR; Lavergne, SN; Maki, JE; Trepanier, LA; Yoder, AR	1
Roychowdhury, S; Svensson, CK; Vyas, PM	1
Clarke, SE; Hollis, FJ; Maggs, JL; Naisbitt, DJ; Park, BK; Sanderson, JP	1
Adeyanju, K; Dekaban, GA; Gilbert, PA; Krizova, A; Rieder, M	1
Sacco, JC; Trepanier, LA	1
Abouraya, M; Bhusari, S; Drescher, NJ; Padilla, ML; Pinkerton, ME; Sacco, JC; Trepanier, LA	1
Alkanani, AK; Frank, DN; Hara, N; Ir, D; Robertson, CE; Wagner, BD; Zipris, D	1
Elzagallaai, AA; Koren, G; Rieder, MJ	1
Bittner, F; Clement, B; Havemeyer, A; Krischkowski, C; Kunze, T; Mendel, RR; Ott, G; Plitzko, B; Reichmann, D	1
Bend, JR; Chen, DF; Rieder, MJ; Xia, XY; Yip, C; Zhang, L	1
Adeyanju, K; Bend, JR; Dekaban, GA; Rieder, MJ	1
Abuzgaia, AM; Bend, JR; Elzagallaai, AA; Loubani, E; Rieder, MJ; Sultan, EA	1

Trials

6 trial(s) available for sulfamethoxazole hydroxylamine and sulfamethoxazole

Article	Year
Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole. British journal of clinical pharmacology, 1994, Volume: 38, Issue:2 Topics: Acetylation; Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Sulfamethoxazole; White People	1994
The hydroxylamine of sulfamethoxazole and adverse reactions in patients with acquired immunodeficiency syndrome. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:2 Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Leucovorin; Male; Middle Aged; Pneumonia, Pneumocystis; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination	1994
Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers. Clinical pharmacology and therapeutics, 1996, Volume: 59, Issue:3 Topics: Adult; Antifungal Agents; Cimetidine; Fluconazole; Histamine H2 Antagonists; Humans; Ketoconazole; Male; Microsomes, Liver; Reference Values; Sulfamethoxazole	1996
The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus. Journal of clinical pharmacology, 1998, Volume: 38, Issue:5 Topics: Adult; Anti-Infective Agents; Anti-Ulcer Agents; Antibiotic Prophylaxis; Cimetidine; Double-Blind Method; Drug Interactions; Female; HIV Infections; Humans; Male; Pilot Projects; Sulfamethoxazole; Trimethoprim	1998
The effect of clarithromycin, fluconazole, and rifabutin on sulfamethoxazole hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283). Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:4 Topics: Adult; Anti-Infective Agents; Area Under Curve; CD4 Lymphocyte Count; Clarithromycin; Drug Interactions; Female; Fluconazole; HIV Infections; HIV-1; Humans; Male; Middle Aged; Rifabutin; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination	2004
Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso. Toxicology, 2006, May-01, Volume: 222, Issue:1-2 Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cell Separation; Cyclic N-Oxides; Drug Hypersensitivity; Female; Glutathione; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidation-Reduction; Spin Labels; Sulfamethoxazole	2006

Other Studies

38 other study(ies) available for sulfamethoxazole hydroxylamine and sulfamethoxazole

Article	Year
Modification of existing antibiotics in the form of precursor prodrugs that can be subsequently activated by nitroreductases of the target pathogen. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Anti-Bacterial Agents; Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Kinetics; Nitroreductases; Prodrugs; Spectrophotometry, Ultraviolet; Staphylococcus; Sulfamethoxazole	2016
Suppression of T-lymphocyte proliferation by sulphonamide hydroxylamines. International journal of immunopharmacology, 1992, Volume: 14, Issue:7 Topics: Cell Survival; Humans; Immune Tolerance; In Vitro Techniques; Lymphocyte Activation; Mitogens; Sulfamethoxazole; T-Lymphocytes	1992
Sulfamethoxazole is metabolized to the hydroxylamine in humans. Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:5 Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Sulfamethoxazole	1992
Cellular toxicity of sulfamethoxazole reactive metabolites--I. Inhibition of intracellular esterase activity prior to cell death. Biochemical pharmacology, 1991, Feb-15, Volume: 41, Issue:4 Topics: Cell Membrane; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Esterases; Fluoresceins; Fluorescence; Humans; Hydrogen-Ion Concentration; Sulfamethoxazole	1991
Cellular toxicity of sulfamethoxazole reactive metabolites--II. Inhibition of natural killer activity in human peripheral blood mononuclear cells. Biochemical pharmacology, 1991, Feb-15, Volume: 41, Issue:4 Topics: Cell Survival; Cells, Cultured; Cytotoxicity, Immunologic; Esterases; Fluorescence; Glutathione; Humans; Killer Cells, Natural; Liver; Sulfamethoxazole	1991
Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: implications for mechanistic toxicology. Analytical biochemistry, 1990, Volume: 191, Issue:2 Topics: Aniline Compounds; Benzoquinones; Calcium; Chromatography, High Pressure Liquid; Cytosol; Fluorescent Dyes; Humans; Imines; Indoles; Ionophores; Kinetics; Leukocytes, Mononuclear; Mitogens; Sulfamethoxazole; Xanthenes	1990
Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogs. Molecular pharmacology, 1990, Volume: 38, Issue:5 Topics: Animals; Biotransformation; Dogs; Humans; Monocytes; Neutrophils; Oxidation-Reduction; Peroxidase; Peroxidases; Prostaglandin-Endoperoxide Synthases; Sulfamethoxazole; Sulfonamides	1990
An in vitro investigation of predisposition to sulphonamide idiosyncratic toxicity in dogs. Veterinary research communications, 1990, Volume: 14, Issue:3 Topics: Animals; Breeding; Cells, Cultured; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Leukocytes, Mononuclear; Male; Microsomes, Liver; Molecular Structure; Sulfamethoxazole	1990
Fluorescence-based viability assay for studies of reactive drug intermediates. Analytical biochemistry, 1989, Volume: 177, Issue:2 Topics: Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Fluorescent Dyes; Humans; Monocytes; Spectrometry, Fluorescence; Sulfamethoxazole	1989
N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Sulfamethoxazole	1995
Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Feb-01, Volume: 8, Issue:2 Topics: Adult; Cells, Cultured; Deltaretrovirus Infections; Dose-Response Relationship, Drug; Drug Hypersensitivity; HIV Infections; Humans; Models, Biological; Sulfamethoxazole; T-Lymphocytes; Toxicity Tests	1995
In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV. Clinical and experimental immunology, 1993, Volume: 94, Issue:1 Topics: Adult; CD4-CD8 Ratio; Cytokines; Cytotoxicity, Immunologic; Drug Hypersensitivity; Glutathione; HIV Infections; Humans; Male; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination	1993
The hydroxylamine of sulfamethoxazole synergizes with FK506 and cyclosporin A, inhibiting T-cell proliferation. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1 Topics: Actins; Cell Division; Cyclosporine; Drug Synergism; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Polyenes; RNA, Messenger; Sirolimus; Sulfamethoxazole; T-Lymphocytes; Tacrolimus	1997
Suppression of pokeweed mitogen-driven human IgM and IgG responses by the hydroxylamine of sulfamethoxazole. International journal of immunopharmacology, 1997, Volume: 19, Issue:5 Topics: Anti-Infective Agents; Antibody Formation; B-Lymphocytes; Humans; Immune Tolerance; Immunoglobulin G; Immunoglobulin M; Leukocytes, Mononuclear; Pokeweed Mitogens; Sulfamethoxazole	1997
Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:13 Topics: Apoptosis; CD8-Positive T-Lymphocytes; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Immunomagnetic Separation; Phosphatidylserines; Sulfamethoxazole; Sulfonamides; T-Lymphocyte Subsets	1999
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. AIDS research and human retroviruses, 2000, Dec-10, Volume: 16, Issue:18 Topics: Adult; Chromatography, High Pressure Liquid; Cysteine; Disease Progression; Drug Hypersensitivity; HIV Infections; HIV-1; Humans; Middle Aged; Oxidation-Reduction; Sulfamethoxazole; Sulfhydryl Compounds	2000
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells. British journal of pharmacology, 2001, Volume: 132, Issue:3 Topics: Adult; Anti-Infective Agents; CD4-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Down-Regulation; Drug Hypersensitivity; Drug Interactions; Female; Glutathione; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Receptors, Antigen, T-Cell; Sulfamethoxazole	2001
NADH-dependent reduction of sulphamethoxazole hydroxylamine in dog and human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:12 Topics: Adult; Animals; Anti-Infective Agents; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Erythromycin; Female; Humans; Inactivation, Metabolic; Kinetics; Male; Microsomes, Liver; Middle Aged; NAD; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Protein Synthesis Inhibitors; Species Specificity; Sulfamethoxazole; Tolbutamide	2000
Effect of lipopolysaccharide (LPS)-evoked host defense activation on hepatic microsomal formation and reduction of sulfamethoxazole hydroxylamine in the rat. Biochemical pharmacology, 2001, Aug-15, Volume: 62, Issue:4 Topics: Animals; Inflammation; Lipopolysaccharides; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Sprague-Dawley; Sulfamethoxazole	2001
Inhibition of cytokine production and interference in IL-2 receptor-mediated Jak-Stat signaling by the hydroxylamine metabolite of sulfamethoxazole. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:10 Topics: Cytokines; DNA-Binding Proteins; Humans; Interferon-gamma; Interleukin-1; Interleukin-4; Janus Kinase 1; Janus Kinase 3; Milk Proteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Interleukin-2; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Sulfamethoxazole; Trans-Activators; Tumor Necrosis Factor-alpha	2001
Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation. European journal of clinical pharmacology, 2002, Volume: 58, Issue:1 Topics: Adult; Antiprotozoal Agents; Aryl Hydrocarbon Hydroxylases; Atovaquone; Blood Proteins; Cells, Cultured; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Microsomes, Liver; Middle Aged; Naphthoquinones; Protein Binding; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfamethoxazole	2002
Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells. Chemico-biological interactions, 2002, Nov-10, Volume: 142, Issue:1-2 Topics: Animals; Anti-Infective Agents; Antibodies; Biotransformation; Blotting, Western; Cytosol; Cytotoxicity Tests, Immunologic; Humans; Hydroxylation; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Sulfamethoxazole; Tetrazolium Salts; Thiazoles; U937 Cells	2002
Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection. Journal of acquired immune deficiency syndromes (1999), 2004, Aug-15, Volume: 36, Issue:5 Topics: Adult; Anti-Infective Agents; Ascorbic Acid; Ascorbic Acid Deficiency; Case-Control Studies; CD4-CD8 Ratio; Cysteine; Dehydroascorbic Acid; Female; Glutathione; HIV Infections; Humans; In Vitro Techniques; Male; Middle Aged; Oxidation-Reduction; Sulfamethoxazole	2004
Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells. Toxicology, 2005, Jan-15, Volume: 206, Issue:2 Topics: Animals; Anti-Infective Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dinitrochlorobenzene; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Female; Interleukin-5; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Nitroso Compounds; Phthalic Anhydrides; Sulfamethoxazole; Th1 Cells; Th2 Cells	2005
Differential toxicity of reactive metabolites of clindamycin and sulfonamides in HIV-infected cells: influence of HIV infection on clindamycin toxicity in vitro. Journal of clinical pharmacology, 2005, Volume: 45, Issue:3 Topics: Animals; Anti-Infective Agents; Biotransformation; Cell Line; Cell Survival; Clindamycin; Coculture Techniques; Drug Combinations; Drug Hypersensitivity; HIV; Mice; Microsomes; Primaquine; Pyrimethamine; Sulfamethoxazole; T-Lymphocytes	2005
Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Life sciences, 2005, May-27, Volume: 77, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Cytochromes b5; Dapsone; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Oxidation-Reduction; Sulfamethoxazole; Swine	2005
Disruption of the endoplasmic reticulum by cytotoxins in LLC-PK1 cells. Toxicology letters, 2005, Nov-15, Volume: 159, Issue:2 Topics: Aniline Compounds; Animals; Calcium; Cell Line; Cell Survival; Cytotoxins; DNA Fragmentation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Fluorescent Dyes; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Iodoacetamide; L-Lactate Dehydrogenase; LLC-PK1 Cells; Membrane Proteins; Molecular Chaperones; Sulfamethoxazole; Swine; tert-Butylhydroperoxide; U937 Cells; Xanthenes	2005
Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4 Topics: Biological Transport; Biotransformation; Cell Differentiation; Cell Line; Dapsone; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Haptens; Humans; Microscopy, Confocal; Oxygenases; Peroxidase; Protein Binding; Proteins; Serum Albumin, Bovine; Sulfamethoxazole; Time Factors	2007
Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12 Topics: Ascorbic Acid; Chromatography, High Pressure Liquid; Deferoxamine; Edetic Acid; Enzyme Inhibitors; Ferrous Compounds; Humans; Hydrogen Peroxide; Hydroxylation; Kinetics; Microsomes, Liver; Molecular Structure; NADP; Sulfamethoxazole; Tandem Mass Spectrometry; Triazoles	2008
HIV Tat potentiates cell toxicity in a T cell model for sulphamethoxazole-induced adverse drug reactions. Virus genes, 2009, Volume: 38, Issue:3 Topics: Apoptosis; Cell Survival; HIV-1; Humans; Jurkat Cells; Sulfamethoxazole; T-Lymphocytes; tat Gene Products, Human Immunodeficiency Virus	2009
Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction. Pharmacogenetics and genomics, 2010, Volume: 20, Issue:1 Topics: Cytochrome-B(5) Reductase; Cytochromes b5; Female; Genetic Association Studies; Haplotypes; Humans; Hydroxylamines; Immunoblotting; Liver; Male; Microsomes, Liver; Middle Aged; Oxidation-Reduction; Polymorphism, Single Nucleotide; Sulfamethoxazole	2010
Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine. Archives of toxicology, 2010, Volume: 84, Issue:8 Topics: Animals; Anti-Infective Agents; Antioxidants; Ascorbic Acid; Ascorbic Acid Deficiency; Cell Proliferation; Cytochrome-B(5) Reductase; Cytochromes b5; Drug Hypersensitivity; Glutathione; Guinea Pigs; Inactivation, Metabolic; Liver; Male; Sulfamethoxazole; T-Lymphocytes	2010
Prevention of virus-induced type 1 diabetes with antibiotic therapy. Journal of immunology (Baltimore, Md. : 1950), 2012, Oct-15, Volume: 189, Issue:8 Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Combinations; Female; Inflammation Mediators; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Parvovirus; Peyer's Patches; Rats; Rats, Inbred Lew; Sulfadoxine; Sulfamethoxazole; Trimethoprim	2012
The predictive value of the in vitro platelet toxicity assay (iPTA) for the diagnosis of hypersensitivity reactions to sulfonamides. Journal of clinical pharmacology, 2013, Volume: 53, Issue:6 Topics: Adolescent; Adult; Aged; Blood Platelets; Case-Control Studies; Child; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Lymphocytes; Male; Middle Aged; Predictive Value of Tests; Reproducibility of Results; Sulfamethoxazole; Sulfonamides; Young Adult	2013
Reduction of sulfamethoxazole hydroxylamine (SMX-HA) by the mitochondrial amidoxime reducing component (mARC). Chemical research in toxicology, 2014, Oct-20, Volume: 27, Issue:10 Topics: Amino Acid Substitution; Animals; Biocatalysis; Chromatography, High Pressure Liquid; Cytochrome-B(5) Reductase; Cytochromes b5; HEK293 Cells; Humans; Kinetics; Liver; Mitochondria; Mitochondrial Proteins; Oxidation-Reduction; Oxidoreductases; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Sulfamethoxazole; Swine	2014
Potential Complementary Therapy for Adverse Drug Reactions to Sulfonamides: Chemoprotection Against Oxidative and Nitrosative Stress by TCM Constituents and Defined Mixtures. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2015, Volume: 18, Issue:4 Topics: Complementary Therapies; Drugs, Chinese Herbal; Humans; Jurkat Cells; Lipid Peroxidation; Medicine, Chinese Traditional; Oxidative Stress; Protein Carbonylation; Reactive Oxygen Species; Sulfamethoxazole	2015
HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells. Virology journal, 2018, 05-09, Volume: 15, Issue:1 Topics: Apoptosis; Disulfides; Gene Expression; HIV-1; Humans; Jurkat Cells; Mutation; Oxidants; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Plasmids; Proteome; Sulfamethoxazole; Sulfhydryl Compounds; tat Gene Products, Human Immunodeficiency Virus; Transgenes	2018
Role of Oxidative Stress in Hypersensitivity Reactions to Sulfonamides. Journal of clinical pharmacology, 2020, Volume: 60, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Blood Platelets; Cell Survival; Child; Drug Hypersensitivity; Drug Tolerance; Female; Glutathione; Healthy Volunteers; Humans; Leukocytes, Mononuclear; Lipid Peroxidation; Lymphocytes; Male; Middle Aged; Oxidative Stress; Patients; Protein Carbonylation; Reactive Oxygen Species; Sulfamethoxazole; Sulfonamides; Young Adult	2020