succinylacetone has been researched along with heme in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (33.77) | 18.7374 |
| 1990's | 27 (35.06) | 18.2507 |
| 2000's | 17 (22.08) | 29.6817 |
| 2010's | 7 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebert, PS; Frykholm, BC; Hess, RA; Tschudy, DP | 2 |
| Castañeda, VL; Guzman, GS; Kinkade, JM; Parmley, RT; Pinnix, IB; Raju, SG | 1 |
| McCormick, S; Nauseef, WM; Yi, H | 1 |
| Padmanaban, G; Surolia, N | 1 |
| Fuchs, O; Hradilek, A; Neuwirt, J | 1 |
| Boynton, SB; Carter, BE; Connor, E; Fowler, B; Roth, KS; Wyss, PA | 1 |
| Padmanaban, G; Venkateswar, V | 1 |
| Affabris, E; Battistini, A; Bulgarini, D; Coccia, EM; Fiorucci, G; Marziali, G; Romeo, G; Rossi, GB; Scalzo, S; Testa, U | 1 |
| Bloomer, JR; Freese, D; Glock, M; Pascual-Leone, A; Payne, W; Rank, JM; Sharp, H | 1 |
| Bement, WJ; Guzelian, PS; Haugen, SA; Li, D; May, BK; Schuetz, EG; Sinclair, JF; Sinclair, PR | 1 |
| Halvorsen, S; Kvittingen, EA; Steen-Johnsen, J; Søvik, O | 1 |
| Carter, BE; Moses, LC; Roth, KS; Spencer, PD | 1 |
| Bain, MD; Bingham, P; Chalmers, RA; Jones, M; Purkiss, P; Stacey, TE | 1 |
| Iwasa, F; Kappas, A; Sassa, S | 1 |
| Adams, ML; Grasso, JA; Ostapiuk, I | 1 |
| Abraham, NG; Ahmed, T; Konwalinka, G; Levere, RD; Nelson, JC | 1 |
| Hansen, AJ; May, BK | 1 |
| Bottomley, SS; Bridges, KR; Wolfe, LC | 1 |
| DeFalco, MG; Giffhorn-Katz, S; Grasso, JA; Katz, NR; Liem, HH; Muller-Eberhard, U | 1 |
| Martinez-Medellin, J; Ponka, P; Schulman, HM | 1 |
| Anderson-Burham, LA; Bloomer, JR; Kang, K | 1 |
| Graber, SG; Woodworth, RC | 1 |
| Beaumont, C; de Verneuil, H; Grandchamp, B; Nordmann, Y | 1 |
| Ponka, P; Schulman, HM | 2 |
| Beru, N; Goldwasser, E; Sahr, K | 1 |
| Iacopetta, B; Morgan, E | 1 |
| Beaumont, C; da Silva, V; de Verneuil, H; Deybach, JC; Grandchamp, B; Nordmann, Y | 1 |
| Giger, U; Meyer, UA | 1 |
| De Matteis, F; Marks, GS | 1 |
| Kappas, A; Sassa, S | 1 |
| Atsmon, A; Ebert, PS; Frykholm, BC; Hess, RA; Tschudy, DP | 1 |
| Ponka, P; Schulman, HM; Wilczynska, A | 1 |
| De Matteis, F; Ray, DE | 1 |
| Atsmon, A; Epstein, O; Greenblat, Y; Schoenfeld, N | 1 |
| Bradley, D; Frykholm, BC; Hruska, RE; Lamon, JM; Silbergeld, EK | 1 |
| Frykholm, BC; Hess, RA; Tschudy, DP | 1 |
| Krantz, SB; Muta, K | 1 |
| Bonkovsky, HL; Cable, EE; Lambrecht, RW; Pepe, JA; Russo, SM | 1 |
| Bonkovsky, HL; Guzman, GS; Kinkade, JM; Pinnix, IB; Zaki, SR | 1 |
| Chan, RY; Kühn, LC; Ponka, P; Schulman, HM; Seiser, C | 1 |
| Boynton, S; Chu, J; Roth, KS; Wyss, PA | 1 |
| Cohan, DS; Garrick, LM; Garrick, MD; Gniecko, K; Grasso, JA; Liu, Y | 1 |
| Baumgartner, M; Bogdan, A; Callebert, J; Deybach, JC; Nordmann, Y; Puy, H; Touitou, Y; Voisin, P | 1 |
| Ponka, P; Richardson, DR; Vyoral, D | 1 |
| Bonkovsky, HL; Cable, EE; Donohue, SE; Gildemeister, OS; Lambrecht, RW; Pepe, JA | 1 |
| Laftah, A; Peters, TJ; Raja, KB; Simpson, RJ | 1 |
| Dinauer, MC; Yu, L; Zhen, L | 1 |
| Pandey, VC; Srivastava, P | 1 |
| Dolan, KG; Garrick, LM; Garrick, MD; Kulju, D; Romano, MA; Scott, D | 1 |
| Avadhani, NG; Damle, S; Lenka, N; Vijayasarathy, C | 1 |
| Bonkovsky, HL; Elbirt, KK; Kolluri, S | 1 |
| Franklin Bunn, H; Horiguchi, H | 1 |
| Abreu, L; Braz, GR; Masuda, H; Oliveira, PL | 1 |
| Berg, CL; Cohn, SM; Luo, RQ; Miller, SK; Worthington, MT | 1 |
| Cable, EE; Isom, HC; Miller, TG | 1 |
| Dailey, HA; Woodard, SI | 1 |
| Lee, HC; Zhang, L; Zhu, Y | 1 |
| Hon, T; Ye, W; Zhang, L; Zhu, Y | 1 |
| Chandra, NR; Chandrasekhar Sagar, BK; Dhanasekaran, S; Padmanaban, G; Rangarajan, PN | 1 |
| Fujita, H; Igarashi, K; Mori, H; Nakanishi, K; Saito, T; Sun, J; Tahara, T; Taketani, S; Yamamoto, M | 1 |
| Ye, W; Zhang, L | 2 |
| Igarashi, K; Sun, J; Tahara, T; Taketani, S | 1 |
| Hon, T; Sengupta, A; Zhang, L | 1 |
| Bonkovsky, HL; Kolluri, S; May, BK; Sadlon, TJ | 1 |
| Laftah, AH; Peters, TJ; Raja, KB; Simpson, RJ | 1 |
| Adams, MA; Nakatsu, K; Soong, J | 1 |
| Kataoka, T; Sakaino, M; Taketani, S | 1 |
| Adams, MA; Benjamin, CD; Bourque, SL; Nakatsu, K | 1 |
| Jaffe, EK; Ramirez, U; Roos, DS; Shanmugam, D; Wu, B | 1 |
| Abdulkarim, BA; Chavan, H; Krishnamurthy, P; Polireddy, K | 1 |
| Hakkola, J; Lämsä, V; Levonen, AL; Sormunen, R; Yamamoto, M | 1 |
| Bonkovsky, HL; Hamilton, A; Hou, W; Hwang, S; Li, T; Parsons, J; Schrum, L; Steuerwald, N; Tian, Q | 1 |
| Fuse, Y; Kobayashi, M; Nakajima, H; Nakajima, O; Nakajima-Takagi, Y | 1 |
| Adachi, Y; Fujisawa, JI; Izawa, S; Ohnishi, K; Sasai, M; Takeda, TA; Taketani, S | 1 |
1 trial(s) available for succinylacetone and heme
| Article | Year |
|---|---|
Hematin therapy for the neurologic crisis of tyrosinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Aminolevulinic Acid; Heme; Hemin; Heptanoates; Humans; Infant; Liver Transplantation; Male; Tyrosine | 1991 |
76 other study(ies) available for succinylacetone and heme
| Article | Year |
|---|---|
Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Heme; Hemoglobins; Heptanoates; Heptanoic Acids; Keto Acids; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Porphobilinogen Synthase | 1979 |
Ultrastructural, immunochemical, and cytochemical study of myeloperoxidase in myeloid leukemia HL-60 cells following treatment with succinylacetone, an inhibitor of heme biosynthesis.
Topics: Heme; Heptanoates; Histocytochemistry; Humans; Immunohistochemistry; Leukemia, Myeloid; Microscopy, Electron; Neutrophils; Peroxidase; Tumor Cells, Cultured | 1992 |
Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidase.
Topics: Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Heme; Heptanoates; Humans; Immunosorbent Techniques; Kinetics; Lysosomes; Microscopy, Electron; Microscopy, Immunoelectron; Neutrophils; Peroxidase; Phosphorylation; Protein Precursors; Receptor, IGF Type 2; Tumor Cells, Cultured | 1992 |
de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Glutamates; Glutamic Acid; Heme; Heptanoates; Isoleucine; Plasmodium falciparum; Porphobilinogen Synthase; Protein Biosynthesis | 1992 |
Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells.
Topics: Animals; Gene Expression; Glutathione Peroxidase; Glycine; Heme; Heptanoates; Iron; Leukemia, Erythroblastic, Acute; Mice; Receptors, Transferrin; RNA, Messenger; Tumor Cells, Cultured | 1992 |
Renal heme metabolism in hereditary tyrosinemia: use of succinylacetone in rat renal tubules.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Cytochrome P-450 Enzyme System; Cytosol; Ferrochelatase; Heme; Heme Oxygenase (Decyclizing); Heptanoates; Kidney Cortex; Kidney Tubules; Male; Models, Biological; Porphyrins; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
Involvement of heme in the transcriptional activation of CYPIIB1/B2 gene by phenobarbitone in rat liver--studies with succinylacetone.
Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Heptanoates; In Vitro Techniques; Liver; Male; Phenobarbital; Porphobilinogen Synthase; Rats; RNA, Messenger; Transcription, Genetic | 1991 |
Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor number, and ferritin content in differentiating Friend erythroleukemia cells.
Topics: Cell Differentiation; Dimethyl Sulfoxide; Ferritins; Globins; Heme; Heptanoates; Humans; Leukemia, Erythroblastic, Acute; Receptors, Transferrin | 1991 |
Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Enzyme Induction; Extracellular Matrix; Heme; Heptanoates; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344; RNA, Messenger | 1990 |
Hereditary tyrosinemia of chronic course without rickets and renal tubular dysfunction.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Child, Preschool; Chronic Kidney Disease-Mineral and Bone Disorder; Female; Heme; Heptanoates; Humans; Hydrolases; Male; Porphobilinogen Synthase; Thrombocytopenia; Tyrosine | 1990 |
On rat renal aminolevulinate transport and metabolism in experimental Fanconi syndrome.
Topics: Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Animals; Biological Transport, Active; Fanconi Syndrome; Heme; Heptanoates; In Vitro Techniques; Kidney Tubules; Male; Maleates; Microvilli; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Dietary treatment eliminates succinylacetone from the urine of a patient with tyrosinaemia type 1.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Heme; Heptanoates; Heptanoic Acids; Humans; Infant; Methionine; Phenylalanine; Tyrosine | 1990 |
delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals.
Topics: 5-Aminolevulinate Synthetase; Carcinoma, Hepatocellular; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Half-Life; Heme; Hemin; Heptanoates; Humans; Iron; Liver Neoplasms; Methylcholanthrene; Time Factors; Tumor Cells, Cultured | 1989 |
The effects of inhibition of heme synthesis on the intracellular localization of iron in rat reticulocytes.
Topics: Animals; Centrifugation, Density Gradient; Chromatography, Gel; Cytoplasm; Heme; Heptanoates; Iron; Iron Radioisotopes; Mitochondria; Rats; Rats, Inbred Strains; Receptors, Transferrin; Reticulocytes | 1989 |
Erythropoietin controls heme metabolic enzymes in normal human bone marrow culture.
Topics: 5-Aminolevulinate Synthetase; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Drug Synergism; Erythrocytes; Erythropoietin; Hematopoietic Stem Cells; Heme; Heme Oxygenase (Decyclizing); Hemin; Heptanoates; Humans; Hydroxymethylbilane Synthase; Osmolar Concentration; Reference Values | 1989 |
Effect of haem on cytochrome P-450 synthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation; Heme; Heptanoates; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Messenger; Steroid 11-beta-Hydroxylase | 1989 |
Iron metabolism in K562 erythroleukemic cells.
Topics: Cell Line; Deferoxamine; Heme; Heptanoates; Humans; Iron; Leukemia, Erythroblastic, Acute; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 1985 |
Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Cycloheximide; Deferoxamine; Heme; Heptanoates; Kinetics; Liver; Mannans; Rats; Receptors, Transferrin; Reference Values | 1988 |
Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes.
Topics: Animals; Depression, Chemical; Endocytosis; Heme; Hemin; Heptanoates; In Vitro Techniques; Iron; Male; Rats; Reticulocytes; Transferrin | 1988 |
Effect of succinylacetone administration on brain heme metabolism and behavior in mice.
Topics: Animals; Behavior, Animal; Brain; Heme; Heptanoates; Heptanoic Acids; Male; Mice; Mice, Inbred BALB C; Porphobilinogen Synthase | 1987 |
Myoglobin expression in L6 muscle cells. Role of differentiation and heme.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Cell Line; Cytarabine; DNA; Ferric Compounds; Heme; Hemin; Heptanoates; Muscles; Myoglobin; Porphobilinogen Synthase; Rats | 1986 |
Accumulation of porphobilinogen deaminase, uroporphyrinogen decarboxylase, and alpha- and beta-globin mRNAs during differentiation of mouse erythroleukemic cells. Effects of succinylacetone.
Topics: Ammonia-Lyases; Animals; Carboxy-Lyases; Cell Differentiation; Electrophoresis, Agar Gel; Friend murine leukemia virus; Globins; Heme; Heptanoates; Heptanoic Acids; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Mice; Nucleic Acid Hybridization; RNA, Messenger; Time Factors; Uroporphyrinogen Decarboxylase | 1985 |
Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis.
Topics: 2,2'-Dipyridyl; Animals; Erythrocytes; Glycine; Heme; Heptanoates; Iron; Isoniazid; Porphyrins; Protoporphyrins; Pyridoxal; Rabbits; Reticulocytes; Transferrin | 1985 |
Inhibition of heme synthesis in bone marrow cells by succinylacetone: effect on globin synthesis.
Topics: Animals; Biological Transport; Bone Marrow; Cells, Cultured; Erythropoietin; Globins; Heme; Heptanoates; Iron; Male; Protein Biosynthesis; Rats; RNA | 1983 |
Heme inhibits transferrin endocytosis in immature erythroid cells.
Topics: Animals; Cycloheximide; Endocytosis; Erythrocyte Aging; Erythrocytes; Heme; Hemin; Heptanoates; Hydrogen-Ion Concentration; Iron; Isoniazid; Liver; Rabbits; Rats; Reticulocytes; Transferrin | 1984 |
Effects of succinylacetone on dimethylsulfoxide-mediated induction of heme pathway enzymes in mouse friend virus-transformed erythroleukemia cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Transformation, Viral; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Induction; Friend murine leukemia virus; Heme; Hemin; Hemoglobins; Heptanoates; Heptanoic Acids; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Mice; Porphobilinogen Synthase | 1984 |
Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte culture.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Heptanoates; Heptanoic Acids; Kinetics; Liver | 1983 |
The effect of N-methylprotoporphyrin and succinyl-acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture.
Topics: 5-Aminolevulinate Synthetase; Animals; Chick Embryo; Ferrochelatase; Heme; Heptanoates; Heptanoic Acids; Liver; Phenobarbital; Porphyrins; Protoporphyrins | 1983 |
Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Cattle; Chick Embryo; Erythrocytes; Heme; Heptanoates; Heptanoic Acids; Humans; In Vitro Techniques; Liver; Mice; Mice, Inbred BALB C; Porphobilinogen Synthase; Species Specificity; Tyrosine | 1983 |
Growth inhibitory activity of succinylacetone: studies with Walker 256 carcinosarcoma, Novikoff hepatoma and L1210 leukemia.
Topics: Animals; Carcinoma 256, Walker; Cell Division; Cells, Cultured; Heme; Hemin; Heptanoates; Heptanoic Acids; Leukemia L1210; Liver; Liver Neoplasms, Experimental; Porphobilinogen Synthase; Rats; Rats, Inbred Strains | 1983 |
Uptake of hematin and growth of malignant murine erythroleukemia cells depleted of endogenous heme by succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Biological Transport; Cell Division; Heme; Hemin; Heptanoates; Heptanoic Acids; Keto Acids; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Temperature | 1981 |
Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitor or heme synthesis.
Topics: Animals; Globins; Heme; Heptanoates; Heptanoic Acids; Iron; Keto Acids; Kinetics; Rabbits; Reticulocytes | 1982 |
Studied on cerebellar haem metabolism in the rat in vivo.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cerebellum; Feedback; Heme; Heptanoates; Kinetics; Male; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Inbred Strains; Tissue Distribution | 1982 |
The effects of succinylacetone (4,6-dioxoheptanoic acid) on delta-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Drug Synergism; Enzyme Induction; Heme; Heptanoates; Heptanoic Acids; Levulinic Acids; Liver; Porphobilinogen Synthase | 1982 |
Neurotoxic aspects of porphyrinopathies: lead and succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Brain; gamma-Aminobutyric Acid; Heme; Heptanoates; Heptanoic Acids; Lead; Porphyrias; Rats; Seizures | 1982 |
The stimulation of globin synthesis by cobalt in reticulocytes with inhibited heme synthesis.
Topics: Animals; Cobalt; Globins; Heme; Heptanoates; Isoniazid; Keto Acids; Kinetics; Protein Biosynthesis; Rabbits; Reticulocytes | 1981 |
Inhibition of delta-aminolevulinic acid dehydrase by 4,6-dioxoheptanoic acid.
Topics: Animals; Binding Sites; Dithiothreitol; Heme; Heptanoates; Heptanoic Acids; Keto Acids; Kinetics; Liver; Porphobilinogen Synthase; Protein Binding; Rats | 1981 |
Inhibition of heme synthesis induces apoptosis in human erythroid progenitor cells.
Topics: Apoptosis; Cells, Cultured; Culture Media; Erythroid Precursor Cells; Erythropoietin; Ferritins; Heme; Heptanoates; Humans; Isoniazid; Proto-Oncogene Proteins c-myc; Recombinant Proteins; Stem Cells; Transferrin | 1995 |
Repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Enzyme Repression; Ferric Compounds; Glutethimide; Heme; Heme Oxygenase (Decyclizing); Heptanoates; Kinetics; Liver; Metalloporphyrins; Nitrilotriacetic Acid; Porphyrias | 1994 |
The post-translational processing of myeloperoxidase is regulated by the availability of heme.
Topics: Cell Compartmentation; Cytoplasmic Granules; Heme; Heptanoates; Humans; Peroxidase; Porphobilinogen Synthase; Protein Processing, Post-Translational; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Erythroid Precursor Cells; Gene Expression Regulation; Heme; Heptanoates; Iron; Iron-Regulatory Proteins; Isoniazid; Mice; Receptors, Transferrin; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 1994 |
Tissue distribution of succinylacetone in the rat in vivo: a possible basis for neurotoxicity in hereditary infantile tyrosinemia.
Topics: Animals; Animals, Newborn; Brain; Heme; Heptanoates; Kidney; Liver; Male; Nervous System Diseases; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tyrosine | 1993 |
Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone.
Topics: Anemia, Hypochromic; Animals; Cytosol; Heme; Heptanoates; Iron; Iron Radioisotopes; Mitochondria; Mutation; Porphobilinogen Synthase; Rats; Rats, Mutant Strains; Reticulocytes; Transferrin | 1993 |
Increased delta aminolevulinic acid and decreased pineal melatonin production. A common event in acute porphyria studies in the rat.
Topics: Acetylserotonin O-Methyltransferase; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminolevulinic Acid; Animals; Arylamine N-Acetyltransferase; Cells, Cultured; Enzyme Inhibitors; gamma-Aminobutyric Acid; Heme; Heptanoates; In Vitro Techniques; Isoproterenol; Male; Melatonin; Norepinephrine; Photoperiod; Pineal Gland; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Rats; Rats, Wistar; Tryptophan | 1996 |
Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism.
Topics: Animals; Blood Proteins; Cell Compartmentation; Cytosol; Deferoxamine; Enzyme Inhibitors; Heme; Hemoglobins; Heptanoates; Iron; Iron Chelating Agents; Membrane Proteins; Mitochondria; Models, Biological; Porphobilinogen Synthase; Protoporphyrins; Rabbits; Reticulocytes; Transferrin | 1996 |
Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Dactinomycin; Deferoxamine; Enzyme Inhibitors; Glutethimide; Heme; Heptanoates; Kinetics; Liver; Metalloporphyrins; Porphobilinogen Synthase; Regression Analysis; RNA, Messenger | 1996 |
Importance of haem biosynthesis in the control of intestinal iron absorption.
Topics: Animals; Duodenum; Enzyme Inhibitors; Heme; Heptanoates; Intestinal Absorption; Intestinal Mucosa; Iron; Mice; Porphobilinogen Synthase | 1997 |
Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits.
Topics: 3T3 Cells; Animals; Cell Differentiation; Cell Membrane; COS Cells; Cytochrome b Group; Dimerization; Enzyme Inhibitors; Enzyme Stability; Granulocytes; Granulomatous Disease, Chronic; Heme; Heptanoates; HL-60 Cells; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Membrane Transport Proteins; Mice; NADPH Dehydrogenase; NADPH Oxidase 2; NADPH Oxidases; Phagocytes; Phosphoproteins; Recombinant Proteins; Superoxides; Transfection; Tumor Cells, Cultured | 1997 |
Heme synthesizing enzymes of Plasmodium knowlesi: a simian malaria parasite.
Topics: 5-Aminolevulinate Synthetase; Animals; Antimalarials; Enzyme Inhibitors; Ferrochelatase; Glycine; Heme; Hemin; Heptanoates; Macaca mulatta; Plasmodium knowlesi; Porphobilinogen Synthase; Tryptophan Oxygenase | 1998 |
Evidence for and consequences of chronic heme deficiency in Belgrade rat reticulocytes.
Topics: Anemia, Hypochromic; Animals; Cell-Free System; Cycloheximide; Disease Models, Animal; Heme; Heptanoates; Iron; Rats; Reticulocytes | 1999 |
Tissue variant effects of heme inhibitors on the mouse cytochrome c oxidase gene expression and catalytic activity of the enzyme complex.
Topics: Adenosine Triphosphate; Animals; Brain; Catalysis; Cobalt; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex IV; Enzyme Induction; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Heptanoates; Iron; Kidney; Mice; Mitochondria; Mitochondria, Liver; Multienzyme Complexes; Organ Specificity; Porphobilinogen Synthase; RNA, Messenger | 1999 |
Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC).
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Chick Embryo; Chickens; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutethimide; Heme; Heptanoates; Liver; Liver Neoplasms; Phenobarbital; RNA, Messenger; Tumor Cells, Cultured | 1999 |
Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis.
Topics: Cell Survival; Deferoxamine; Enzyme Inhibitors; Erythropoietin; Heme; Heptanoates; Humans; Isoniazid; Protoporphyrins; Tumor Cells, Cultured | 2000 |
Heme biosynthesis and oogenesis in the blood-sucking bug, Rhodnius prolixus.
Topics: Animals; Blood; Carrier Proteins; Eating; Female; Heme; Heme-Binding Proteins; Hemeproteins; Hemolymph; Heptanoates; Oogenesis; Porphobilinogen Synthase; Rhodnius | 2001 |
Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines.
Topics: Carrier Proteins; Cell Line; Cell Membrane; Enzyme Inhibitors; Heme; Heptanoates; Humans; Intestinal Mucosa; Intestines; Kinetics; Liver; Metalloporphyrins; Temperature | 2001 |
Regulation of heme metabolism in rat hepatocytes and hepatocyte cell lines: delta-aminolevulinic acid synthase and heme oxygenase are regulated by different heme-dependent mechanisms.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Line; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hepatocytes; Heptanoates; Kinetics; Models, Biological; Porphobilinogen Synthase; Rats; RNA, Messenger; Tumor Cells, Cultured | 2000 |
Multiple regulatory steps in erythroid heme biosynthesis.
Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Heme; Heptanoates; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Porphyrins; Tumor Cells, Cultured | 2000 |
An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells.
Topics: Actins; Animals; Cell Cycle Proteins; Cell Differentiation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Deferoxamine; Enzyme Inhibitors; Erythropoiesis; Gene Expression Profiling; Gene Expression Regulation; Heme; Heptanoates; Humans; Iron Chelating Agents; K562 Cells; Neurons; Oligonucleotide Array Sequence Analysis; PC12 Cells; Rats; Tumor Suppressor Proteins | 2002 |
Heme deficiency interferes with the Ras-mitogen-activated protein kinase signaling pathway and expression of a subset of neuronal genes.
Topics: Animals; Blotting, Northern; Blotting, Western; Carrier Proteins; Enzyme Activation; Enzyme Inhibitors; Heme; Heptanoates; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; Neurons; PC12 Cells; ras Proteins; Rats; Receptor, trkA | 2002 |
Delta-aminolevulinic acid dehydratase from Plasmodium falciparum: indigenous versus imported.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cations; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Erythrocytes; Escherichia coli; Glutathione Transferase; Heme; Heptanoates; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Magnesium; Microscopy, Immunoelectron; Models, Molecular; Molecular Sequence Data; Peptides; Plasmodium falciparum; Porphobilinogen Synthase; Potassium; Recombinant Fusion Proteins; Recombinant Proteins; RNA; Sequence Homology, Amino Acid; Zinc | 2004 |
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Binding Sites; Blotting, Northern; Cell Line; Chelating Agents; Chromatin; Deferoxamine; Dimerization; Erythroid Cells; Fanconi Anemia Complementation Group Proteins; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Globins; Heme; Heptanoates; Humans; Iron; K562 Cells; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred BALB C; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; RNA; RNA, Messenger; Transcription Factors | 2004 |
Heme controls the expression of cell cycle regulators and cell growth in HeLa cells.
Topics: Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation; HeLa Cells; Heme; Heptanoates; Humans; In Situ Nick-End Labeling; Matrix Metalloproteinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nuclear Proteins; Phosphorylation; Promyelocytic Leukemia Protein; Proto-Oncogene Proteins c-raf; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2004 |
Heme deficiency causes apoptosis but does not increase ROS generation in HeLa cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Division; Cell Survival; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Heme; Heptanoates; Humans; In Situ Nick-End Labeling; Membrane Potentials; Mitochondria; Reactive Oxygen Species | 2004 |
Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Cell Nucleus; DNA-Binding Proteins; Enhancer Elements, Genetic; Enzyme Inhibitors; Erythroid Cells; Erythroid-Specific DNA-Binding Factors; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Genes, Reporter; Globins; Heme; Hemin; Heptanoates; Humans; K562 Cells; Mice; Multigene Family; NF-E2 Transcription Factor; NF-E2 Transcription Factor, p45 Subunit; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic; Up-Regulation | 2004 |
Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death.
Topics: Animals; Apoptosis; Caspases; Cell Survival; Collagen Type XI; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heme; Heptanoates; MAP Kinase Signaling System; Membrane Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Neurons; PC12 Cells; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Porphyrias; Rats; RNA-Binding Proteins; RNA, Messenger; SMN Complex Proteins; Up-Regulation; Vesicular Transport Proteins | 2005 |
Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH.
Topics: 5-Aminolevulinate Synthetase; Animals; Cell Line, Tumor; Chickens; Down-Regulation; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glutethimide; Heme; Heptanoates; Promoter Regions, Genetic; Up-Regulation | 2005 |
The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Antimicrobial Cationic Peptides; Duodenum; Enzyme Inhibitors; Heme; Hepcidins; Heptanoates; Intestinal Absorption; Iron Compounds; Male; Mice; Porphobilinogen; Porphobilinogen Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Acute depletion of heme by succinylacetone alters vascular responses but does not induce hypertension.
Topics: Animals; Blood Pressure; Blood Vessels; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Heptanoates; Hypertension; Male; Microsomes; Nitric Oxide Synthase; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Sprague-Dawley | 2008 |
Post-transcriptional regulation of the expression of ferrochelatase by its variant mRNA.
Topics: Animals; Cell Line; Enzyme Inhibitors; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Hemin; Heptanoates; Humans; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats.
Topics: Aminolevulinic Acid; Animals; Blood Pressure; Guanylate Cyclase; Heme; Hemodynamics; Heptanoates; Hypertension; Kidney; Male; Nitric Oxide Synthase; Organ Specificity; Porphobilinogen Synthase; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sodium; Soluble Guanylyl Cyclase | 2010 |
Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential.
Topics: Animals; Antiprotozoal Agents; Catalytic Domain; Cloning, Molecular; Gene Expression Regulation, Enzymologic; Genome; Heme; Heptanoates; Humans; Ions; Kinetics; Metals; Mice; Plastids; Porphobilinogen Synthase; Protein Structure, Quaternary; Protein Transport; Protozoan Proteins; Recombinant Proteins; Reproducibility of Results; Subcellular Fractions; Toxoplasma | 2010 |
Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma.
Topics: ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Disease Progression; G2 Phase; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Heme; Heptanoates; Humans; Liver Neoplasms; Mitosis; Tumor Stem Cell Assay; Up-Regulation | 2011 |
Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bilirubin; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Endoplasmic Reticulum; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase-1; Hemin; Hepatocytes; Heptanoates; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NF-E2-Related Factor 2; Protoporphyrins | 2012 |
Heme status affects human hepatic messenger RNA and microRNA expression.
Topics: Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation; Heme; Heptanoates; Humans; Liver; MicroRNAs; Oligonucleotide Array Sequence Analysis; Protoporphyrins; RNA, Messenger; Time Factors | 2013 |
Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Biosynthetic Pathways; Fanconi Anemia Complementation Group Proteins; Heme; Heme Oxygenase-1; Hemin; Heptanoates; Larva; Liver; Metabolic Networks and Pathways; NF-E2-Related Factor 2; Organ Specificity; Zebrafish; Zebrafish Proteins | 2015 |
Potential role of heme metabolism in the inducible expression of heme oxygenase-1.
Topics: Arsenites; Basic-Leucine Zipper Transcription Factors; Carbon Monoxide; Enzyme Induction; Fanconi Anemia Complementation Group Proteins; HEK293 Cells; HeLa Cells; Heme; Heme Oxygenase-1; Heptanoates; Humans; Isothiocyanates; Protoporphyrins; Sodium Compounds; Sulfoxides | 2017 |