succinic semialdehyde has been researched along with gamma-aminobutyric acid in 82 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (41.46) | 18.7374 |
| 1990's | 5 (6.10) | 18.2507 |
| 2000's | 18 (21.95) | 29.6817 |
| 2010's | 23 (28.05) | 24.3611 |
| 2020's | 2 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Goochee, C; Kaufman, EE; Nelson, T; Sokoloff, L | 1 |
| Barker, HA; Bozler, G; Hensley, C; Ohsugi, M; Robertson, JM | 1 |
| Kawamata, I; Matsuda, M | 1 |
| Hudspeth, ME; Meganathan, R; Palaniappan, C; Sharma, V | 1 |
| Kaufman, EE; Nelson, T | 2 |
| Bruinvels, J; Fekkes, D; Schouten, MJ; van Bemmelen, FJ | 1 |
| Martin, DL; Martin, SB; Porter, TG | 1 |
| Hechler, V; Maitre, M; Mandel, P; Vayer, P | 1 |
| Brown, GK; Cromby, CH; Manning, NJ; Pollitt, RJ | 1 |
| Kaufman, EE; Miller, D; Nelson, T; Stadlan, N | 1 |
| Gibson, KM; Nyhan, WL; Pattarelli, PP | 1 |
| Fales, HM; Kaufman, EE; Levin, DM; Nelson, T | 1 |
| Henson, JM; Marek, LE | 1 |
| Alvarez, MA; Balaña, R; Garrido-Pertierra, A; Sànchez, M | 1 |
| Biondi, P; Manzocchi, A; Santaniello, E; Secchi, C | 1 |
| Cromlish, JA; Flynn, TG; Yoshimoto, CK | 1 |
| Forte-McRobbie, CM; Pietruszko, R | 1 |
| Brown, GK; Danks, DM; Gibson, KM; Haan, EA; Jansen, I; Nyhan, WL; Sweetman, L | 1 |
| Martin, DL; Martin, SB; Porter, TG; Spink, DC | 1 |
| Taberner, PV | 1 |
| Divry, P; Hanefeld, F; Hermier, M; Jakobs, C; Kneer, J; Rating, D; Siemes, H | 1 |
| Divry, P; Hanefeld, F; Hermier, M; Jakobs, C; Kneer, J; Rating, D | 1 |
| Cañadas, S; González, MP; Morales, V; Muñoz, F; Sánchez-Prieto, J | 1 |
| Gibson, KM; Sweetman, L | 1 |
| Bruinvels, J; Jacobs, AW; van der Laan, JW | 1 |
| Farrelly, JG; Hecker, LI; Stewart, ML | 1 |
| Cooper, RA; Donnelly, MI | 1 |
| Rivett, AJ; Tipton, KF | 1 |
| Bojasch, M; Hanefeld, F; Jakobs, C; Mönch, E; Rating, D; Siemes, H | 1 |
| Rivett, AJ; Smith, IL; Tipton, KF | 1 |
| Manzocchi, A; Santaniello, E | 1 |
| Kenealy, WR; Wolff, RA | 1 |
| Cho, SW; Choi, EY; Choi, SY; Hong, JW; Jang, SH; Lee, JE; Park, KA; Suk, JW; Yoo, BK | 1 |
| Harrison, DJ; Hayes, JD; Ireland, LS; Neal, GE | 1 |
| Bartolini, P; Bianchi, L; Capodarca, S; Cunningham, CM; Dachour, A; De Witte, P; Della Corte, L; Lallemand, F; Quertemont, E; Tipton, KF; Ward, RJ | 1 |
| Crouch, DH; Hayes, JD; Kelly, VP; Sherratt, PJ | 1 |
| Ellis, E; Hinshelwood, A; McGarvie, G | 1 |
| Nguyen, E; Picklo, MJ | 1 |
| Chatterjee, AK; Nayak, P | 1 |
| Amarnath, V; Gibson, KM; Murphy, TC; Picklo, MJ | 1 |
| MONFOORT, CH | 2 |
| ALBERS, RW; SALVADOR, RA | 1 |
| HOLZER, H; WITT, I | 1 |
| Vorob'ev, VE | 1 |
| Bravo, DT; Harris, DO; Parsons, SM | 1 |
| Bryk, R; Itoh, M; Nathan, C; Suematsu, M; Tian, J | 1 |
| Gibson, KM; Jakobs, C; Jansen, EE; Struys, EA | 1 |
| Wang, C; Wang, LH; Zhang, HB; Zhang, LH | 1 |
| Gibson, KM; Hoffmann, GF; Jakobs, C; Kölker, S; Okun, JG; Sauer, SW; Ten Brink, HJ | 1 |
| Brichac, J; Ho, KK; Honzatko, A; Lu, X; Picklo, MJ; Wang, R; Weiner, H | 1 |
| Ilg, T; Jaeger, M; Rothacker, B | 1 |
| Begley, TP; Hilmey, DG; Mukherjee, T | 1 |
| Ge, F; Ohnishi, K; Yagi, T; Yokochi, N; Yoshikane, Y; Yuan, B | 1 |
| Kakazu, Y; Kochi, H; Matsuo, G; Robert, M; Saito, N; Soga, T; Tomita, M | 1 |
| Fuchs, G; Kockelkorn, D | 1 |
| Abdenur, JE; Buechner, J; Christensen, E; de Kremer, RD; Errami, A; Gibson, KM; Gissen, P; Gradowska, W; Hobson, E; Islam, L; Jakobs, C; Korman, SH; Kranendijk, M; Kurczynski, T; Maranda, B; Meli, C; Rizzo, C; Salomons, GS; Sansaricq, C; Struys, EA; Trefz, FK; Webster, R; Wickenhagen, WV | 1 |
| Begley, TP; Ealick, SE; McCulloch, KM; Mukherjee, T | 1 |
| Feehily, C; Ham, R; Karatzas, KA; O'Byrne, CP | 1 |
| de Carvalho, LP; Ling, Y; Rhee, KY; Shen, C; Warren, JD | 1 |
| Kusano, M; Matsumoto, N; Oiwaka, A; Okada, K; Saito, K; Tameshige, T; Tatematsu, K; Toyokura, K; Tsugeki, R; Watanabe, K | 1 |
| Ma, L; Meng, X; Tang, H; Wang, L; Xu, P; Yao, Y; Yu, H; Zhang, D | 1 |
| Boughton, BA; Dobson, RC; Hutton, CA | 1 |
| Gökcan, H; Konuklar, FA | 1 |
| Bräsen, C; Esser, D; Kouril, T; Polkowska, J; Schrader, T; Siebers, B; Talfournier, F | 1 |
| Beigi, M; Eggeling, L; Fries, A; Müller, M; Sprenger, GA; Waltzer, S | 1 |
| Chan, MC; Claridge, TD; Flashman, E; Kawamura, A; Leung, IK; Loik, ND; McCullagh, JS; Rydzik, AM; Schofield, CJ; Tarhonskaya, H | 1 |
| Lee, KS; Park, SA; Park, YS | 1 |
| Deppenmeier, U; Meyer, M; Schweiger, P | 1 |
| Jimenez, S; Luca, G; Tafti, M; Vaucher, A; Vienne, J | 1 |
| Han, L; Peng, Q; Song, F; Wang, G; Wang, P; Wang, W; Yang, M; Zhang, J | 1 |
| Kumar, S; Punekar, NS | 1 |
| Bryant, DA; Liu, Y; Zhang, S | 1 |
| Gao, YG; Tang, D; Wang, C; Zhang, LH | 1 |
| Ludewig, F; Mekonnen, DW | 1 |
| Adam-Vizi, V; Chinopoulos, C; Fodor, V; Horvath, K; Kacso, G; Ravasz, D | 1 |
| Capo, C; Ciminelli, BM; Donati, MA; Falconi, M; Funghini, S; Iacovelli, F; Leo, S; Malaspina, P; Menduti, G; Rossi, L | 1 |
| Briozzo, P; Hájková, E; Jašková, L; Končitíková, R; Kopečná, M; Kopečný, D; Moréra, S; Šebela, M; Vigouroux, A; Vilím, J; von Schwartzenberg, K | 1 |
| Chaiyen, P; Maenpuen, S; Munkajohnpong, P; Phonbuppha, J; Tinikul, R | 1 |
| Arning, E; Ashcraft, P; Bottiglieri, T; Brown, M; Gibson, KM; Jansen, E; Kirby, T; Rinaldo, P; Roullet, JB; Salomons, GS; Turgeon, C; Walters, DC | 1 |
| Ichinose, Y; Matsui, H; Noutoshi, Y; Toyoda, K; Tumewu, SA; Yamamoto, M | 1 |
2 review(s) available for succinic semialdehyde and gamma-aminobutyric acid
| Article | Year |
|---|---|
An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway.
Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Dehydrogenases; Carbon; Catalysis; Cytosol; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Ketoglutaric Acids; Kinetics; Mitochondria; Mitochondrial Proteins; Oxidation-Reduction; Sodium Oxybate | 1991 |
Function of gamma-hydroxybutyrate: a putative neurotransmitter.
Topics: Animals; Binding Sites; Brain; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Neurotransmitter Agents; Sodium Oxybate | 1987 |
1 trial(s) available for succinic semialdehyde and gamma-aminobutyric acid
| Article | Year |
|---|---|
[Dynamics of local oxygen consumption an extraction under the condition of altered oxygen turnover in humans during head-down bed rest].
Topics: Adult; Blood Volume; gamma-Aminobutyric Acid; Humans; Hypokinesia; Male; Oxygen; Oxygen Consumption; Plethysmography, Impedance; Time Factors | 2003 |
79 other study(ies) available for succinic semialdehyde and gamma-aminobutyric acid
| Article | Year |
|---|---|
Purification and characterization of an NADP+-linked alcohol oxido-reductase which catalyzes the interconversion of gamma-hydroxybutyrate and succinic semialdehyde.
Topics: Aldehydes; Animals; Brain; Cricetinae; Cytosol; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Kinetics; Liver; Male; Mesocricetus; Molecular Weight; NADP; Substrate Specificity; Succinates; Tissue Distribution | 1979 |
Metabolism of L-beta-lysine in a Pseudomonas: conversion of 6-N-acetyl-L-beta-lysine to 3-keto-6-acetamidohexanoate and of 4-aminobutyrate to succinic semialdehyde by different transaminases.
Topics: Aminocaproates; Aminocaproic Acid; Enzyme Induction; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Kinetics; Lysine; Pseudomonas; Pyridoxal Phosphate; Pyruvates; Substrate Specificity; Transaminases | 1979 |
Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.
Topics: Aldehydes; Animals; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Mice; Penicillamine; Pyridoxine; Pyrimidines; Seizures; Semicarbazides; Succinates | 1976 |
Menaquinone (vitamin K2) biosynthesis: evidence that the Escherichia coli menD gene encodes both 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase activities.
Topics: Amino Acid Sequence; Anaerobiosis; Base Sequence; Carboxy-Lyases; Cloning, Molecular; DNA, Bacterial; Escherichia coli; gamma-Aminobutyric Acid; Genes, Bacterial; Molecular Sequence Data; Oxo-Acid-Lyases; Sequence Homology, Amino Acid; Vitamin K | 1992 |
Succinic semialdehyde as a substrate for the formation of gamma-aminobutyric acid.
Topics: 4-Aminobutyrate Transaminase; Animals; Carbon Radioisotopes; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kinetics; Male; Rats; Rats, Inbred Strains | 1985 |
Activation of glutamate apodecarboxylase by succinic semialdehyde and pyridoxamine 5'-phosphate.
Topics: Apoenzymes; Apoproteins; Binding, Competitive; Enzyme Activation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Glyoxylates; Ketoglutaric Acids; Kinetics; Oxaloacetates; Pyridoxamine; Pyruvates; Pyruvic Acid | 1986 |
Evidence for the participation of a cytosolic NADP+-dependent oxidoreductase in the catabolism of gamma-hydroxybutyrate in vivo.
Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Glucuronates; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Keto Acids; Kidney; Male; Muscles; Phenylacetates; Rats; Rats, Inbred Strains; Sodium Oxybate; Sodium Salicylate; Valproic Acid | 1987 |
Urinary organic acids in succinic semialdehyde dehydrogenase deficiency: evidence of alpha-oxidation of 4-hydroxybutyric acid, interaction of succinic semialdehyde with pyruvate dehydrogenase and possible secondary inhibition of mitochondrial beta-oxidati
Topics: Adipates; Carboxylic Acids; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Infant; Oxidation-Reduction; Propionates; Pyruvate Dehydrogenase Complex | 1987 |
Oxidation of gamma-hydroxybutyrate to succinic semialdehyde by a mitochondrial pyridine nucleotide-independent enzyme.
Topics: Animals; Brain; Carbon Dioxide; Cytosol; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Immunoassay; Kidney; Male; Mitochondria; NAD; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sodium Oxybate; Valproic Acid | 1988 |
Oxidation of [U-14C]succinic semialdehyde in cultured human lymphoblasts: measurement of residual succinic semialdehyde dehydrogenase activity in 11 patients with 4-hydroxybutyric aciduria.
Topics: Aldehyde Oxidoreductases; Carbon Dioxide; Cells, Cultured; Child; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Infant; Kinetics; Lactates; Lactic Acid; Lymphocytes; Male; Malonates; Oxidation-Reduction; Sodium Oxybate; Succinate-Semialdehyde Dehydrogenase; Succinates; Succinic Acid; Valproic Acid | 1988 |
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria.
Topics: 3-Hydroxybutyric Acid; Animals; Chromatography, Paper; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutarates; Hydrogen-Ion Concentration; Hydroxybutyrates; Kidney; Kinetics; Mitochondria; NAD; NADP; Rats; Sodium Oxybate; Time Factors | 1988 |
Cloning and expression of the Escherichia coli K-12 sad gene.
Topics: Bacterial Proteins; Chromosome Mapping; Cloning, Molecular; Cosmids; DNA, Bacterial; Escherichia coli; gamma-Aminobutyric Acid; Gene Expression Regulation; Genes, Bacterial; Hydroxybutyrate Dehydrogenase; Mutation; Nucleic Acid Hybridization; Plasmids | 1988 |
Properties and functions of two succinic-semialdehyde dehydrogenases from Pseudomonas putida.
Topics: Cations, Divalent; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Kinetics; Molecular Weight; NAD; NADP; Pseudomonas; Putrescine; Temperature | 1988 |
Studies on analogues of succinic semialdehyde as substrates for succinate semialdehyde dehydrogenase from rat brain.
Topics: Aldehyde Oxidoreductases; Animals; Brain; Cyclopropanes; gamma-Aminobutyric Acid; Isomerism; Kinetics; Rats; Succinate-Semialdehyde Dehydrogenase | 1986 |
Purification and characterization of four NADPH-dependent aldehyde reductases from pig brain.
Topics: Alcohol Oxidoreductases; Animals; Brain; Cell Fractionation; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Molecular Weight; Stereoisomerism; Substrate Specificity; Swine | 1985 |
Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase.
Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Aldehyde Dehydrogenase; gamma-Aminobutyric Acid; Humans; Isoelectric Focusing; Kinetics; Liver; Molecular Weight; NAD; Oxidoreductases Acting on CH-NH Group Donors; Substrate Specificity | 1986 |
Properties of succinic semialdehyde dehydrogenase in cultured human lymphoblasts.
Topics: Cell-Free System; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Lymphocytes; NAD; Sodium Oxybate; Temperature | 1985 |
Transaminations catalysed by brain glutamate decarboxylase.
Topics: Aminobenzoates; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hydrogen-Ion Concentration; Isoenzymes; Models, Chemical; Pyridoxamine; Spectrophotometry; Swine | 1985 |
Alcohol dehydrogenase activity in rat brain: evidence for the metabolism of succinic semialdehyde to gamma-hydroxybutyrate.
Topics: Alcohol Oxidoreductases; Aldehydes; Animals; Brain; gamma-Aminobutyric Acid; Horses; Hydroxybutyrates; Kinetics; Rats; Succinates; Tritium | 1974 |
4-Hydroxybutyric aciduria: a new inborn error of metabolism. I. Clinical review.
Topics: Adolescent; Ataxia; Child; Female; gamma-Aminobutyric Acid; Humans; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Male; Metabolism, Inborn Errors; Sodium Oxybate | 1984 |
4-Hydroxybutyric aciduria: a new inborn error of metabolism. II. Biochemical findings.
Topics: Adolescent; Child; Female; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Male; Metabolism, Inborn Errors; Sodium Oxybate | 1984 |
Method of assay for 4-aminobutyrate-2-oxoglutarate aminotransferase.
Topics: 4-Aminobutyrate Transaminase; Animals; Colorimetry; gamma-Aminobutyric Acid; Ketoglutaric Acids; Phenylhydrazines; Rats | 1983 |
Enzymatic preparation of radiolabeled succinic semialdehyde.
Topics: Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; gamma-Aminobutyric Acid; Humans; Isotope Labeling | 1983 |
Effects of branched-chain fatty acids on GABA-degradation and behavior: further evidence for a role of GABA in quasi-morphine abstinence behavior.
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Brain Chemistry; Caproates; Dose-Response Relationship, Drug; Fatty Acids; gamma-Aminobutyric Acid; Humans; Male; Morphine Dependence; Pentanoic Acids; Rats; Rats, Inbred Strains; Valproic Acid | 1980 |
The metabolism of nitrosopyrrolidine by hepatocytes from Fischer rats.
Topics: Amino Acids; Animals; Carbon Dioxide; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Kinetics; Liver; Male; N-Nitrosopyrrolidine; Nitrosamines; Rats; Tetrahydrofolates | 1982 |
Succinic semialdehyde dehydrogenases of Escherichia coli: their role in the degradation of p-hydroxyphenylacetate and gamma-aminobutyrate.
Topics: Aldehyde Oxidoreductases; Enzyme Induction; Escherichia coli; gamma-Aminobutyric Acid; NAD; NADP; Phenylacetates; Succinate-Semialdehyde Dehydrogenase (NADP+) | 1981 |
Kinetic studies of the reduction of succinic semialdehyde by rat-brain aldehyde reductase.
Topics: Alcohol Oxidoreductases; Animals; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; NADP; Oxidation-Reduction; Rats | 1981 |
Urinary excretion of gamma-hydroxybutyric acid in a patient with neurological abnormalities. The probability of a new inborn error of metabolism.
Topics: Fatty Acids, Nonesterified; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Infant; Male; Nervous System Diseases; Sodium Oxybate | 1981 |
The enzymes catalysing succinic semialdehyde reduction in rat brain.
Topics: Animals; Barbital; Brain; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; In Vitro Techniques; Kinetics; NAD; NADP; Rats; Sodium Oxybate | 1981 |
A simple and convenient preparation of succinic semialdehyde.
Topics: Aldehyde Oxidoreductases; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; gamma-Aminobutyric Acid; Indicators and Reagents; Methods; Succinate-Semialdehyde Dehydrogenase (NADP+) | 1980 |
Purification and characterization of the oxygen-sensitive 4-hydroxybutanoate dehydrogenase from Clostridium kluyveri.
Topics: Air; Bacterial Proteins; Chromatography, Gel; Clostridium; Copper; Enzyme Activation; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Hydroxybutyrate Dehydrogenase; Iron; Kinetics; Metalloproteins; Molecular Weight; NAD; Oxygen; Protein Conformation | 1995 |
Distribution of succinic semialdehyde reductase in rat brain.
Topics: Animals; Antibodies, Monoclonal; Brain; Cattle; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Immunoenzyme Techniques; Limbic System; Microscopy, Immunoelectron; Rats; Reticular Formation; Sodium Oxybate; Tissue Distribution | 1997 |
Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.
Topics: Aflatoxin B1; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Isoenzymes; Liver; Molecular Sequence Data; Potassium Channels; Protein Structure, Secondary; Rats; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Substrate Specificity | 1998 |
Effects of ethanol and glutamate agonist infusion on the outflow of sulphoacetaldehyde: microdialysis studies.
Topics: Acetaldehyde; Animals; Brain; Ethanol; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Indans; Microdialysis; Perfusion; Rats | 2000 |
Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Catalysis; Cells, Cultured; Chromatography, Ion Exchange; Cloning, Molecular; Cytosol; Dimerization; DNA, Complementary; Female; gamma-Aminobutyric Acid; Golgi Apparatus; Humans; Immunoblotting; Immunohistochemistry; Kinetics; Liver; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sequence Homology, Amino Acid; Sodium Oxybate; Subcellular Fractions; Substrate Specificity | 2002 |
Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Catalysis; Cloning, Molecular; Enzyme Induction; Ethoxyquin; gamma-Aminobutyric Acid; Humans; Hydroxybutyrate Dehydrogenase; Liver; Mice; Molecular Sequence Data; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution | 2002 |
Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.
Topics: Acrolein; Aldehyde Oxidoreductases; Aldehydes; Animals; Brain Chemistry; gamma-Aminobutyric Acid; Glutathione; Lipid Peroxidation; Male; Mitochondria; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Succinate-Semialdehyde Dehydrogenase | 2003 |
Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain.
Topics: 4-Aminobutyrate Transaminase; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Body Weight; Brain; Brain Chemistry; Cerebellum; Chlorides; Diet, Protein-Restricted; Dietary Proteins; Drug Administration Schedule; Eating; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Telencephalon; Thalamus | 2003 |
Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehyde Oxidoreductases; Aldehydes; Animals; Benomyl; Brain Chemistry; Ditiocarb; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Mitochondria; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Succinate-Semialdehyde Dehydrogenase | 2003 |
On the ratio of thiamine pyrophosphate content and rate of succinic semialdehyde production in homogenates of various muscles of normal and thiamine-deficient pigeons.
Topics: Animals; Columbidae; gamma-Aminobutyric Acid; Muscles; Thiamine; Thiamine Pyrophosphate; Vitamin B Deficiency | 1952 |
Restoration of acetoin and succinic semialdehyde formation in pigeon muscle homogenates impaired by thiamine deficiency.
Topics: Acetoin; Animals; Columbidae; gamma-Aminobutyric Acid; Ketones; Muscles; Succinates; Thiamine; Thiamine Deficiency; Vitamin B Deficiency | 1954 |
Succinic semialdehyde oxidation by a soluble dehydrogenase from brain.
Topics: Brain; gamma-Aminobutyric Acid; Hemorrhage; Humans; Oxidation-Reduction; Oxidoreductases; Succinates | 1958 |
[DEMONSTRATION OF C14-LABELLED SUCCINIC SEMIALDEHYDE].
Topics: Aldehydes; Carbon Isotopes; gamma-Aminobutyric Acid; Glutamates; Indicators and Reagents; Radioisotopes; Radionuclide Imaging; Research; Succinates | 1963 |
Reliable, sensitive, rapid and quantitative enzyme-based assay for gamma-hydroxybutyric acid (GHB).
Topics: Central Nervous System Depressants; Chromatography, Affinity; Cloning, Molecular; Cupriavidus necator; Escherichia coli; Ethanol; Forensic Medicine; gamma-Aminobutyric Acid; Genes, Bacterial; Humans; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; NAD; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Topics: Bacterial Proteins; Blotting, Western; Carboxy-Lyases; Citric Acid Cycle; Enzymes; gamma-Aminobutyric Acid; Glutamic Acid; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Species Specificity | 2005 |
Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography-tandem mass spectrometry: application to SSADH deficiency.
Topics: Blood Chemical Analysis; Calibration; Chromatography; Chromatography, Liquid; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Humans; Hydrazines; Linear Models; Mass Spectrometry; Mitochondria; Models, Chemical; Reproducibility of Results | 2005 |
Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens.
Topics: Agrobacterium tumefaciens; Aldehyde Dehydrogenase; Bacterial Proteins; Carboxylic Ester Hydrolases; Escherichia coli; gamma-Aminobutyric Acid; Gene Expression Regulation, Bacterial; Models, Biological; Molecular Structure; Operon; Promoter Regions, Genetic; Protein Binding; Sequence Deletion; Signal Transduction; Succinate-Semialdehyde Dehydrogenase | 2006 |
Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice).
Topics: Animals; Brain; Brain Diseases, Metabolic, Inborn; Citric Acid Cycle; Disease Models, Animal; Electron Transport; Energy Metabolism; gamma-Aminobutyric Acid; Glutathione; Mice; Mice, Knockout; Mitochondria; Mitochondrial Diseases; Oxidative Stress; Sodium Oxybate; Subcellular Fractions; Succinate-Semialdehyde Dehydrogenase | 2007 |
Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehydes; Animals; Catalysis; Cations, Divalent; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; gamma-Aminobutyric Acid; Isoenzymes; Kinetics; Magnesium; Models, Molecular; NAD; Oxidation-Reduction; Protein Conformation; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2007 |
Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases.
Topics: Alanine; Aldehydes; Animals; Binding Sites; Cloning, Molecular; Cysteine; Drosophila Proteins; Enzyme Inhibitors; Escherichia coli Proteins; gamma-Aminobutyric Acid; Hydrocarbons, Aromatic; NAD; NADP; Nuclear Magnetic Resonance, Biomolecular; Substrate Specificity; Succinate-Semialdehyde Dehydrogenase | 2008 |
PLP catabolism: identification of the 2-(Acetamidomethylene)succinate hydrolase gene in Mesorhizobium loti MAFF303099.
Topics: Alphaproteobacteria; Bacterial Proteins; Cloning, Molecular; DNA Primers; Escherichia coli; gamma-Aminobutyric Acid; Hydrolases; Kinetics; Pseudomonas; Pyridoxal Phosphate; Recombinant Proteins; Succinate-Semialdehyde Dehydrogenase | 2008 |
Gene identification and characterization of the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid amidohydrolase from Mesorhizobium loti MAFF303099.
Topics: Alphaproteobacteria; Amidohydrolases; Bacterial Proteins; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Escherichia coli; gamma-Aminobutyric Acid; Gene Expression; Genes, Bacterial; Hydrogen-Ion Concentration; Hydrolases; Pyridoxine; Succinate-Semialdehyde Dehydrogenase; Temperature | 2008 |
Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Arabidopsis; Enzyme Activation; Escherichia coli K12; Escherichia coli Proteins; gamma-Aminobutyric Acid; Hydroxybutyrate Dehydrogenase; Metabolome; Molecular Sequence Data; Sequence Homology, Amino Acid; Sodium Oxybate; Stress, Physiological; Succinate-Semialdehyde Dehydrogenase | 2009 |
Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales.
Topics: Acyl Coenzyme A; Archaeal Proteins; Autotrophic Processes; Escherichia coli; gamma-Aminobutyric Acid; Hydroxybutyrates; Lactic Acid; Malondialdehyde; Oxidoreductases; Recombinant Proteins; Sulfolobales | 2009 |
Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria.
Topics: Alcohol Oxidoreductases; Algorithms; Body Fluids; DNA Mutational Analysis; gamma-Aminobutyric Acid; Genotype; Glutarates; Homozygote; Humans; Models, Genetic; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Mutation; Reproducibility of Results | 2010 |
Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase.
Topics: Alphaproteobacteria; Amino Acid Sequence; Bacterial Proteins; Catalysis; Catalytic Domain; Enzyme Stability; gamma-Aminobutyric Acid; Hydrolases; Hydrolysis; Molecular Sequence Data; Multigene Family; Protein Binding; Substrate Specificity; Vitamin B 6 | 2010 |
A modified rapid enzymatic microtiter plate assay for the quantification of intracellular γ-aminobutyric acid and succinate semialdehyde in bacterial cells.
Topics: Aminobutyrates; Bacteria; Chemistry Techniques, Analytical; gamma-Aminobutyric Acid | 2011 |
On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis.
Topics: Amino Acid Sequence; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mycobacterium tuberculosis; NADP; Nuclear Magnetic Resonance, Biomolecular; Sequence Alignment; Stereoisomerism; Substrate Specificity; Succinate-Semialdehyde Dehydrogenase | 2011 |
Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis.
Topics: Arabidopsis; Arabidopsis Proteins; Body Patterning; gamma-Aminobutyric Acid; Gene Expression Regulation, Plant; Genes, Plant; Green Fluorescent Proteins; Meristem; Metabolomics; Mutation; Phenotype; Plant Leaves; Succinate-Semialdehyde Dehydrogenase | 2011 |
A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.
Topics: Bacterial Proteins; gamma-Aminobutyric Acid; Gene Deletion; Genome, Bacterial; Mixed Function Oxygenases; Nicotine; Protein Structure, Tertiary; Pseudomonas putida; Pyridines | 2011 |
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; gamma-Aminobutyric Acid; Hydro-Lyases; Ligands; Protein Conformation; Protein Multimerization; Pyruvic Acid | 2012 |
Theoretical study on HF elimination and aromatization mechanisms: a case of pyridoxal 5' phosphate-dependent enzyme.
Topics: 4-Aminobutyrate Transaminase; gamma-Aminobutyric Acid; Hydrofluoric Acid; Models, Molecular; Molecular Structure; Pyridoxal Phosphate; Quantum Theory | 2012 |
Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus.
Topics: Archaeal Proteins; gamma-Aminobutyric Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Ketoglutaric Acids; Kinetics; Methylmalonate-Semialdehyde Dehydrogenase (Acylating); Nitrogen; Pentose Phosphate Pathway; Phylogeny; Polyamines; Succinate-Semialdehyde Dehydrogenase; Sulfolobus solfataricus | 2013 |
TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation.
Topics: Catalysis; Citric Acid Cycle; Escherichia coli; Escherichia coli Proteins; gamma-Aminobutyric Acid; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Mycobacterium tuberculosis; Pyruvate Oxidase | 2013 |
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
Topics: Alcohol Oxidoreductases; Ascorbic Acid; gamma-Aminobutyric Acid; Glutarates; Oxygenases; Succinic Acid | 2014 |
Kinetic characterization and molecular modeling of NAD(P)(+)-dependent succinic semialdehyde dehydrogenase from Bacillus subtilis as an ortholog YneI.
Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; gamma-Aminobutyric Acid; Kinetics; Models, Molecular; Molecular Sequence Data; NAD; NADP; Recombinant Proteins; Sequence Alignment; Succinate-Semialdehyde Dehydrogenase | 2014 |
Succinic semialdehyde reductase Gox1801 from Gluconobacter oxydans in comparison to other succinic semialdehyde-reducing enzymes.
Topics: Coenzymes; gamma-Aminobutyric Acid; Gene Expression; Gluconobacter oxydans; Hydroxybutyrate Dehydrogenase; Molecular Weight; NAD; NADP; Oxidation-Reduction; Protein Multimerization; Substrate Specificity | 2015 |
Central and peripheral metabolic changes induced by gamma-hydroxybutyrate.
Topics: Alcohol Oxidoreductases; Animals; Body Composition; Cell Respiration; Cerebral Cortex; Corticosterone; Fatty Acids, Omega-3; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione Disulfide; Growth Hormone; Hydroxybutyrates; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Mitochondrial Proteins; Oxidation-Reduction; Prolactin; S-Adenosylhomocysteine; Weight Gain | 2015 |
Activation of gab cluster transcription in Bacillus thuringiensis by γ-aminobutyric acid or succinic semialdehyde is mediated by the Sigma 54-dependent transcriptional activator GabR.
Topics: Bacillus thuringiensis; Binding Sites; DNA, Bacterial; gamma-Aminobutyric Acid; Gene Expression Regulation, Bacterial; Promoter Regions, Genetic; Protein Binding; Transcription Factors; Transcription, Genetic | 2014 |
Characterization of succinic semialdehyde dehydrogenase from Aspergillus niger.
Topics: Adenosine Monophosphate; Aspergillus niger; Benzaldehydes; Binding, Competitive; Biocatalysis; Fungal Proteins; gamma-Aminobutyric Acid; Kinetics; Mycelium; NAD; Protein Binding; Substrate Specificity; Succinate-Semialdehyde Dehydrogenase | 2015 |
Metabolic engineering of Synechococcus sp. PCC 7002 to produce poly-3-hydroxybutyrate and poly-3-hydroxybutyrate-co-4-hydroxybutyrate.
Topics: Cyanobacteria; gamma-Aminobutyric Acid; Gene Deletion; Hydroxybutyrates; Metabolic Engineering; Metabolic Networks and Pathways; Mutation; Polyesters; RNA, Messenger; Synechococcus | 2015 |
Succinic Semialdehyde Promotes Prosurvival Capability of Agrobacterium tumefaciens.
Topics: Agrobacterium tumefaciens; Bacterial Proteins; gamma-Aminobutyric Acid; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Metabolic Networks and Pathways; Microarray Analysis; Microbial Viability; Nitrates; Operon; Oxidative Stress | 2016 |
Phenotypic and chemotypic studies using Arabidopsis and yeast reveal that GHB converts to SSA and induce toxicity.
Topics: Aldehyde Oxidoreductases; Arabidopsis; Carbon; Citric Acid Cycle; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Hydroxybutyrates; Mutation; Phenotype; Saccharomyces cerevisiae | 2016 |
Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation.
Topics: Adjuvants, Anesthesia; Animals; Female; gamma-Aminobutyric Acid; Male; Metabolism; Mice; Mice, Inbred C57BL; Mitochondria; Phosphorylation; Sodium Oxybate; Substrate Specificity | 2017 |
SSADH deficiency in an Italian family: a novel ALDH5A1 gene mutation affecting the succinic semialdehyde substrate binding site.
Topics: Amino Acid Metabolism, Inborn Errors; Binding Sites; Computer Simulation; Developmental Disabilities; DNA; Female; gamma-Aminobutyric Acid; HEK293 Cells; Heterozygote; Humans; Infant; Models, Molecular; Mutation; Mutation, Missense; Pedigree; Sodium Oxybate; Succinate-Semialdehyde Dehydrogenase | 2017 |
The ALDH21 gene found in lower plants and some vascular plants codes for a NADP
Topics: Bryophyta; Ferns; gamma-Aminobutyric Acid; Genes, Plant; Phylogeny; Protein Conformation; Structure-Activity Relationship; Substrate Specificity; Succinate-Semialdehyde Dehydrogenase; Succinic Acid | 2017 |
Selective determination of the catalytic cysteine pK
Topics: Acinetobacter baumannii; Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Kinetics; NADP; Sequence Homology, Amino Acid; Substrate Specificity; Succinate-Semialdehyde Dehydrogenase | 2018 |
Post-mortem tissue analyses in a patient with succinic semialdehyde dehydrogenase deficiency (SSADHD). I. Metabolomic outcomes.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Brain; Carnitine; Creatine; Creatinine; Developmental Disabilities; gamma-Aminobutyric Acid; Glycine; Humans; Male; Metabolomics; Succinate-Semialdehyde Dehydrogenase | 2020 |
Requirement of γ-Aminobutyric Acid Chemotaxis for Virulence of Pseudomonas syringae pv. tabaci 6605.
Topics: Bacterial Proteins; Chemotaxis; gamma-Aminobutyric Acid; Nicotiana; Plant Diseases; Pseudomonas syringae; Receptors, GABA; Sequence Deletion; Virulence | 2020 |