substance p has been researched along with pyrrolidonecarboxylic acid in 212 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (25.94) | 18.7374 |
| 1990's | 123 (58.02) | 18.2507 |
| 2000's | 29 (13.68) | 29.6817 |
| 2010's | 5 (2.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oehme, P; Richter, R | 1 |
| Boix, F; Huston, JP; Schwarting, RK | 1 |
| Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K; Terenius, L | 2 |
| Ferretti, JA; Jernigan, RL; Jiang, SP; Sumner, SC | 1 |
| Chang, FY; Lee, SD; Wang, PS; Yeh, GH | 2 |
| Beaujouan, JC; Chassaing, G; Glowinski, J; Lavielle, S; Loeuillet, D; Petitet, F; Saffroy, M; Torrens, Y | 1 |
| Gerhardt, P; Hasenöhrl, RU; Huston, JP | 2 |
| Coghill, RC; Frenk, H; Kellstein, DE; Mao, J; Mayer, DJ | 1 |
| Iwabuchi, Y; Masuhara, T; Sofuku, S | 1 |
| Garcia Anton, JM; Haro, I; Reig, F; Torres, JL; Valencia, G | 1 |
| Hagan, RM; Jones, BJ; Jordan, CC; Tyers, MB | 1 |
| Otsuka, M; Yanagisawa, M | 1 |
| Chorev, M; Gilon, C; Laufer, R; Selinger, Z; Wormser, U | 1 |
| Iwamoto, I; Kimura, A; Nakagawa, N; Tomioka, H; Yamazaki, H; Yoshida, S | 2 |
| Kisara, K; Manome, Y; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
| Herrera-Marschitz, M; Reid, MS; Terenius, L; Ungerstedt, U | 1 |
| Kisara, K; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K; Terenius, L; Yamada, T | 1 |
| Andrews, PV; Boyd, RL; Eglezos, A; Helme, RD | 1 |
| Elliott, PJ; Lorens, SA; Mitsushio, H; Paris, JM | 1 |
| Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D | 1 |
| Guard, S; Suman-Chauhan, N; Watling, KJ; Williams, BJ | 1 |
| Barnes, JM; Barnes, NM; Costall, B; Cox, AJ; Domeney, AM; Kelly, ME; Naylor, RJ | 1 |
| Lachowicz, L; Turski, WA | 3 |
| Gunne, L; Johansson, PE; Liminga, U | 1 |
| Dixon, DM; Fone, KC | 1 |
| Bar-Akiva, G; Chorev, M; Cordopatis, P; Gilon, C; Halle, D; Karagiannis, K; Selinger, Z; Stavropoulos, G | 1 |
| Chorev, M; Gilon, C; Laufer, R; Roques, BP; Roubini, E; Selinger, Z | 1 |
| Maggi, CA; Patacchini, R; Quartara, L; Rovero, P; Santicioli, P | 1 |
| Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-no, K; Yamada, T | 1 |
| Byk, G; Chorev, M; Gilon, C; Halle, D; Selinger, Z | 1 |
| Chang, FY; Ouyang, A; Sharp, D | 1 |
| Fardin, V; Garret, C | 1 |
| Hagan, RM; Jordan, CC; Karagiannis, K; Manolopoulou, A; Poulos, C; Stavropoulos, G | 1 |
| Charlton, CG; Helke, CJ; Keeler, JR | 2 |
| Koziołkiewicz, W; Lachowicz, L; Turska, E; Wasiak, T | 1 |
| Loewy, AD; Sanders, NL; Sawyer, WB; Takano, Y | 1 |
| Koziołkiewicz, W; Lachowicz, L; Turski, WA | 1 |
| Chorev, M; Friedman, ZY; Gilon, C; Rubini, E; Selinger, Z; Wormser, U | 1 |
| Barth, A; Bergmann, J; Hartrodt, B; Jakubke, HD; Lindau, J; Mehlis, B; Neubert, K; Rüger, M | 1 |
| Kubicki, J; Meltzer, B; Traczyk, WZ | 1 |
| Alpert, JE; Bannon, MJ; Elliott, PJ; Iversen, SD | 1 |
| de Caro, G; Massi, M | 1 |
| Elliott, PJ; Iversen, SD | 2 |
| Rice, WR; Singleton, FM | 1 |
| Chorev, M; Gilon, C; Laufer, R; Selinger, Z | 1 |
| Calas, B; Cave, A; Lecaer, JP; Michelot, R; Parello, J; Potier, P | 1 |
| Butler, A; Hagan, RM; Hill, JM; Ireland, SJ; Jordan, CC; Tyers, MB | 1 |
| Chorev, M; Ewenson, A; Gilon, C; Goldin, E; Karmeli, F; Laufer, R; Rachmilewitz, D; Selinger, Z; Silkoff, P | 1 |
| Chorev, M; Devor, M; Frey, J; Gilon, C; Laufer, R; Papir-Kricheli, D; Selinger, Z | 1 |
| Helke, CJ; O'Neill, JT; Phillips, ET | 1 |
| Magneney, S; Mayer, M; Michelot, R; Potier, P; Schmitt, P | 1 |
| Elliott, PJ | 1 |
| Bennett, GW; Fone, KC; Johnson, JV; Marsden, CA | 1 |
| Lorens, SA; Mitsushio, H; Paris, JM | 1 |
| Drapeau, G; Maggi, CA; Meli, A; Patacchini, R; Regoli, D; Renzi, D; Rovero, P; Santicioli, P; Surrenti, C | 1 |
| Chang, KS; Li, XS; Tanz, RD | 1 |
| Harting, J; Reuss, K; Wienrich, M | 1 |
| Barbanti, G; Beneforti, P; Maggi, CA; Meli, A; Patacchini, R; Rovero, P; Santicioli, P; Turini, D | 1 |
| Bennett, GW; Dixon, DM; Fone, KC; Marsden, CA | 1 |
| Kisara, K; Ohba, M; Sakurada, S; Sakurada, T; Yamada, T | 1 |
| Crawley, JN; Stivers, JA | 1 |
| Bermejo, J; Nieto, JL; Rico, M; Santoro, J | 1 |
| Babinska, A; Cierniewski, CS; Janecka, A; Koziolkiewicz, W | 1 |
| Del Rio, J; Naranjo, JR | 1 |
| Kubicki, J; Traczyk, WZ | 1 |
| Duriasz, H; Gajewska, S; Janicki, P; Mészáros, J; Szreniawski, Z; Tarchalska, B | 1 |
| Chorev, M; Friedman, ZY; Gilon, C; Laufer, R; Selinger, Z; Wormser, U | 2 |
| Cieszkowski, M; Jaworek, J; Konturek, SJ; Pawlik, W; Tasler, J | 1 |
| Lamers, CB; Modlin, IM; Walsh, JH | 1 |
| Antkowiak, K; Gregorowicz, K; Kosiński, S | 1 |
| Eison, AS; Hanley, MR; Iversen, LL; Iversen, SD; Sandberg, BE; Watson, SP | 1 |
| Lechago, J; Rosenquist, GL; Walsh, JH; Wong, HC | 1 |
| Brundish, DE; Eison, AS; Hanley, MR; Sandberg, BE; Wade, R; Watson, SP | 1 |
| Eison, AS; Eison, MS; Iversen, SD | 1 |
| Iversen, SD | 1 |
| Cotrait, M; Hospital, M | 1 |
| Dray, A; Hanley, MR; Pinnock, RD; Sandberg, BE | 1 |
| Costa, E; Del Río, J; Naranjo, JR; Yang, HY | 1 |
| Lembeck, F; Lundberg, JM; Saria, A; Skofitsch, G | 1 |
| de Wied, D; Gaffori, O; Stewart, JM | 1 |
| Burt, DR; Sharif, NA | 1 |
| Babińska, A; Cierniewski, CS; Janecka, A; Kosiołkiewicz, W | 1 |
| Iversen, LL; Watson, SP | 1 |
| Beaujouan, JC; Glowinski, J; Saffroy, M; Torrens, Y | 3 |
| Broccardo, M; Improta, G; Severini, C | 1 |
| Fujiwara, Y; Ishii, H; Kusunoki, M; Nakao, K; Utsunomiya, J; Yamamura, T | 1 |
| Maggi, CA; Patacchini, R | 1 |
| Altier, N; Stewart, J | 3 |
| Bock, MD; Doble, A; Fardin, V; Garret, C; Heuillet, E; Le Guern, J; Mayaux, JF; Ménager, J; Pradier, L | 1 |
| Fong, TM; Huang, RR; Strader, CD; Yu, H | 1 |
| Bordey, A; Emonds-Alt, X; Feltz, P; Gauthier, T; Le Fur, G; Lefevre, IA; Oury-Donat, F; Soubrie, P; Thurneyssen, O | 1 |
| Burcher, E; Lavielle, S; Zeng, XP | 1 |
| Boni, P; Evangelista, S; Maggi, CA | 1 |
| Maggi, CA; Meini, S; Patacchini, R | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Meini, S; Patacchini, R; Potier, E; Quartara, L; Sisto, A | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Davison, JS; Mathison, R | 3 |
| Goso, C; Manzini, S; Palma, C | 1 |
| Burcher, E; Stamatakos, C | 1 |
| Brunissen, A; Carruette, A; Chassaing, G; Garret, C; Lavielle, S | 1 |
| Hall, JM; Mitchell, D; Morton, IK | 1 |
| Burcher, E; Zeng, XP | 1 |
| Katsumata, K; Kisara, K; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 2 |
| Aunis, D; Bader, MF; Vitale, N | 1 |
| Katsumata, K; Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
| Cornish, JL; van den Buuse, M | 3 |
| Anagnostides, S; Chorev, M; Karagiannis, K; Ministrouski, I; Selinger, Z; Stavropoulos, G | 1 |
| Chang, DK; Guo, W; Lee, CM; Wong, TC | 1 |
| Djamgoź, MB; Downing, JE | 1 |
| Giuliani, S; Maggi, CA; Meini, S; Patacchini, R | 1 |
| Amodeo, P; Chorev, M; Halle, D; Naider, F; Ron, D; Saviano, G; Selinger, Z; Tallon, M; Temussi, PA | 1 |
| Itoshima, T; Kato, N; Masui, A; Nakajima, T; Tsunashima, K; Yanaihara, N | 1 |
| Iwamoto, I; Nakagawa, N; Yoshida, S | 1 |
| Bock, MD; Clerc, F; Fardin, V; Flamand, O; Foucault, F; Garret, C; Jolly, A | 1 |
| Brunner, S; John, C; Tanaka, DT | 1 |
| Ahluwalia, A; Giuliani, S; Maggi, CA | 1 |
| Glowinski, J | 1 |
| Betschart, J; Blanchard, JC; Garret, C; Grall, I; Piot, O; Ravard, S | 1 |
| Jafri, MS; Weinreich, D | 1 |
| Coelho, J; Martins, A; Mattioli, R | 1 |
| Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH | 1 |
| Bitan, G; Byk, G; Gilon, C; Halle, D; Selinger, Z; Zeltser, I | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML | 1 |
| John, C; Kazem, E; Tanaka, DT | 1 |
| Cavero, I; Floch, A; Thiry, C | 1 |
| Bertrand, C; Emanueli, C; Figini, M; Geppetti, P; Javdan, P | 1 |
| Carmody, J; Messlinger, K; Pawlak, M | 1 |
| Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Nguyen-Le, XK; Regoli, D | 1 |
| Hastrup, H; Schwartz, TW | 1 |
| Baldwin, DH; Christie, AE; Graubard, K; Marder, E | 1 |
| Chikama, T; Nakamura, M; Nishida, T; Ofuji, K | 1 |
| Fox, AJ; Naeem, S; Patel, IA; Urbán, L; Walpole, C | 1 |
| Taché, Y; Yang, H | 1 |
| Baker, CW; Ernst, SA; Ohnishi, H; Williams, JA; Yule, DI | 1 |
| Bertrand, C; Emanueli, C; Figini, M; Geppetti, P; Regoli, D; Sicuteri, R | 1 |
| Beaujouan, JC; Chassaing, G; Glowinski, J; Lavielle, S; Saffroy, M; Sagan, S; Torrens, Y | 1 |
| Cornish, JL; Van den Buuse, M; Wilks, DP | 1 |
| Bunnett, NW; Moore, BA; Sharkey, KA; Vanner, S | 1 |
| Baamonde, A; Hidalgo, A; Menéndez, L | 1 |
| Berthier, A; Dreux, C; Huleux, C; Rossignol, B | 1 |
| Cody, C; Jones, RS; Maubach, KA | 1 |
| Kisara, K; Sakurada, T; Tan-No, K | 1 |
| Evans, RH; Ofner, S; Olpe, HR; Pozza, MF; Schoeffel, C | 1 |
| Criscuoli, M; Lippi, A; Maggi, CA; Santicioli, P | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Bourque, MJ; Robitaille, R | 1 |
| van den Buuse, M | 1 |
| Ciucci, A; Manzini, S; Palma, C; Werge, TM | 1 |
| Endo, T; Hamaue, N; Hirafuji, M; Ihira, E; Kikuchi, K; Kisara, K; Minami, M; Monma, Y; Sakurada, T; Tan-no, K | 1 |
| Alvarez-Vega, M; Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L | 1 |
| Löfgren, O; Lundeberg, T; Qi, Y | 1 |
| Boquet, D; Couraud, JY; Créminon, C; Frobert, Y; Grassi, J; Sagot, MA; Wijkhuisen, A | 1 |
| Inoue, M; Kisara, K; Ohba, M; Sakurada, C; Sakurada, S; Sakurada, T; Tan-No, K; Yuhki, M | 1 |
| Hasenöhrl, RU; Huston, JP; Nikolaus, S | 1 |
| Barbot, L; Cellier, E; Couture, R; Iyengar, S | 1 |
| Broccardo, M; Improta, G; Tabacco, A | 1 |
| Katsuyama, S; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K | 1 |
| Motoi, H; Sato, K; Suzuki, Y | 1 |
| Yang, H; Yuan, PQ | 1 |
| Catanzariti, R; van Den Buuse, M | 1 |
| Amadesi, S; Bertrand, C; Geppetti, P; Nadel, JA; Ricciardolo, FL; Trevisani, M | 1 |
| Potargowicz, E; Traczyk, WZ | 1 |
| Huston, JP; Nikolaus, S; Schwarting, RK | 1 |
| Holzer, P; Shahbazian, A | 1 |
| Bertrand, PP; Bian, XC; Bornstein, JC; Furness, JB | 1 |
| Broccardo, M; Improta, G | 1 |
| Alvarez-Vega, M; Baamonde, A; Hidalgo, A; Menéndez, L | 1 |
| Cassone, MC; Collino, M; Dianzani, C; Fantozzi, R; Ferrara, C; Lombardi, G | 1 |
| Lewis, MW; Travagli, RA | 1 |
| Allouard, N; Bert, L; Bougault, I; Le-Fur, G; Rodier, D; Soubrié, P; Steinberg, R | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Masler, EP | 1 |
| Baamonde, A; Hidalgo, A; Lastra, A; Menéndez, L; Villanueva, N | 1 |
| Broccardo, M; Improta, G; Linari, G; Nucerito, V | 1 |
| Furuta, S; Mobarakeh, JI; Onodera, K; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, H; Watanabe, T; Yanai, K | 1 |
| Aggio, A; Ciccocioppo, R; Loreto, MF; Onori, L; Taddei, G; Tonini, M; Vicini, R | 1 |
| Bolle, P; Severini, C; Tucci, P; Valeri, P | 1 |
| Furuta, T; Kaneko, T; Koyano, K; Tomioka, R; Yanagawa, Y | 1 |
| Fletcher, PJ; Placenza, FM; Rotzinger, S; Vaccarino, FJ | 1 |
| De Lima, TC; Duarte, FS; Testolin, R | 1 |
| Balhorn, A; Dakhama, A; El Gazzar, M; Gelfand, EW; Joetham, A; Kanehiro, A; Kodama, T; Larsen, GL; Loader, JE; Miyahara, N; Park, JW; Takeda, K; Taube, C | 1 |
| Nies, M; Ro, JY; Zhang, Y | 1 |
| De Man, JG; De Schepper, HU; De Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC | 2 |
| Blier, P; Gobbi, G | 1 |
| Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A | 1 |
| Bian, GL; Chen, LW; Wang, YQ; Wei, LC; Yung, KL | 1 |
| Kobayashi, T; Namiki, A; Satoh, JI; Tohse, N; Watanabe, H; Yamakage, M | 1 |
| Katsuyama, S; Kohno, K; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Shiohira, H; Tsuzuki, M | 1 |
| Mizoguchi, H; Sakurada, S; Watanabe, C; Yonezawa, A | 1 |
| Chan, YS; Chen, LW; Chu, JM; Yung, KK | 1 |
| Andrade, D; Bertolin, TC; Blaber, M; Caliendo, G; Juliano, L; Juliano, MA; Kondo, MY; Oliveira, JR; Oliveira, LC; Santagada, V; Santos, JA; Severino, B | 1 |
| De Lima, TC; Duarte, FS; Duzzioni, M; Leme, LR; Smith, Sde P | 1 |
| Bleeker, D; Heitman, LH; IJzerman, AP; Nederpelt, I; Tuijt, B | 1 |
6 review(s) available for substance p and pyrrolidonecarboxylic acid
| Article | Year |
|---|---|
Bulbospinal substance P and sympathetic regulation of the cardiovascular system: a review.
Topics: Animals; Autonomic Fibers, Preganglionic; Bicuculline; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Efferent Pathways; gamma-Aminobutyric Acid; Hypertension; Injections, Spinal; Medulla Oblongata; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred SHR; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P; Sympathetic Nervous System; Synaptic Transmission | 1985 |
Behavioural effects of substance P through dopaminergic pathways in the brain.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Diencephalon; Dopamine; Drug Stability; Endopeptidases; Exploratory Behavior; Hydroxydopamines; Limbic System; Metalloendopeptidases; Motor Activity; Neural Pathways; Neurons; Oxidopamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Telencephalon | 1982 |
The 'septide-sensitive' tachykinin receptor: still an enigma.
Topics: Animals; Cell Line; DNA, Complementary; Guinea Pigs; Ileum; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Tachykinin; Substance P; Transfection; Type C Phospholipases; Urinary Bladder | 1995 |
[Pharmacological profile of sendide, a tachykinin NK-1 receptor antagonist].
Topics: Analgesics; Animals; Biphenyl Compounds; Mice; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Spinal Cord; Substance P | 1997 |
Role of the mesolimbic dopamine system in cardiovascular homeostasis. Stimulation of the ventral tegmental area modulates the effect of vasopressin on blood pressure in conscious rats.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Consciousness; Dopamine; Drug Interactions; Homeostasis; Limbic System; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Substance P; Vasopressins; Ventral Tegmental Area | 1998 |
Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs.
Topics: Animals; Antidepressive Agents; Hippocampus; Humans; Indoles; Isoindoles; Ligands; Models, Neurological; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Serotonin; Substance P | 2005 |
206 other study(ies) available for substance p and pyrrolidonecarboxylic acid
| Article | Year |
|---|---|
Effect of substance P sequences on isolated neurons of Lymnaea stagnalis.
Topics: Acetylcholine; Animals; Brain; Dose-Response Relationship, Drug; Electric Conductivity; Eledoisin; Lymnaea; Membrane Potentials; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Tubocurarine | 1983 |
The C-terminal fragment of substance P enhances dopamine release in nucleus accumbens but not in neostriatum in freely moving rats.
Topics: Animals; Corpus Striatum; Dialysis; Dopamine; Male; Motor Activity; Neostriatum; Nucleus Accumbens; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Substance P | 1992 |
A selective and extremely potent antagonist of the neurokinin-1 receptor.
Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Binding, Competitive; Cell Membrane; Dose-Response Relationship, Drug; Injections, Spinal; Kinetics; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Structure-Activity Relationship; Substance P; Tachykinins | 1992 |
Conformational analysis of receptor selective tachykinin analogs: senktide and septide.
Topics: Amino Acid Sequence; Circular Dichroism; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Substance P | 1992 |
The motor actions of natural neurokinins and their specific agonists on the gastrointestinal tract of the rat.
Topics: Animals; Charcoal; Gastrointestinal Motility; Injections, Intraperitoneal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Pilot Projects; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1992 |
[A new tachykinin receptor revealed by substance P analogues in the guinea pig ileum].
Topics: Animals; Cell Membrane; Duodenum; Guinea Pigs; Ileum; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P | 1992 |
Positively reinforcing effects of the neurokinin substance P in the basal forebrain: mediation by its C-terminal sequence.
Topics: Animals; Conditioning, Psychological; Male; Microinjections; Motor Activity; Olivary Nucleus; Peptide Fragments; Prosencephalon; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Reinforcement, Psychology; Stereotyped Behavior; Substance P | 1992 |
Calcitonin gene-related peptide enhances substance P-induced behaviors via metabolic inhibition: in vivo evidence for a new mechanism of neuromodulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Bombesin; Calcitonin Gene-Related Peptide; Catheterization; Dose-Response Relationship, Drug; Drug Synergism; Injections, Spinal; Kainic Acid; Male; Microinjections; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine; Substance P | 1992 |
Sialogogic effects on rat submandibular gland of analogs of the C-terminal hexapeptide of substance P.
Topics: Animals; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Salivation; Submandibular Gland; Substance P | 1992 |
Synthesis and purification of two SP (6-11) analogues with enhanced selectivity for the NK-1 receptor.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1990 |
Effect of 5-HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amygdala; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Electric Stimulation; Hydroxyindoleacetic Acid; Injections; Limbic System; Male; Neural Pathways; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Serotonin Antagonists; Stereotaxic Techniques; Substance P | 1990 |
Pharmacological profile of a tachykinin antagonist, spantide, as examined on rat spinal motoneurones.
Topics: Analgesics; Animals; Animals, Newborn; Motor Neurons; Neurokinin A; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P; Tachykinins; Tetrodotoxin | 1990 |
Proteolytic resistance and biological activity of N-methylated analogs of [pGlu6] substance P6-11.
Topics: Animals; Hypothalamus; In Vitro Techniques; Methylation; Parotid Gland; Peptide Fragments; Peptide Hydrolases; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1990 |
Differential effects of two C-terminal peptides of substance P on human neutrophils.
Topics: Calcium; Chemotaxis, Leukocyte; Cytosol; Dose-Response Relationship, Drug; Humans; Neutrophils; Osmolar Concentration; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Superoxides | 1990 |
The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Injections, Spinal; Mice; Mice, Inbred Strains; N-Methylaspartate; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1990 |
Intranigral substance P modulation of striatal dopamine: interaction with N-terminal and C-terminal substance P fragments.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Injections; Male; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
N-terminal substance P fragments inhibit the spinally induced, NK 1 receptor mediated behavioural responses in mice.
Topics: Animals; Behavior, Animal; Bombesin; Injections, Spinal; Male; Mice; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Somatostatin; Spinal Cord; Substance P; Tachykinins | 1990 |
Tachykinin-mediated modulation of the primary antibody response in rats: evidence for mediation by an NK-2 receptor.
Topics: Animals; Animals, Newborn; Antibody Formation; Capsaicin; Denervation; Female; Immune System; Lymph Nodes; Male; Neurokinin A; Peptide Fragments; Peripheral Nerves; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1991 |
Neuronal sites mediating locomotor hyperactivity following central neurokinin agonist administration.
Topics: Animals; Brain; Catheterization; Cerebral Ventricles; Chromatography, High Pressure Liquid; Haloperidol; Hydroxydopamines; Infusions, Parenteral; Male; Motor Activity; Muscimol; Neurons; Oxidopamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Tegmentum Mesencephali | 1990 |
Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer.
Topics: Animals; Azepines; Cimetidine; Ethanol; Gastric Acid; Gastric Mucosa; Gastrins; Hydroxyzine; In Vitro Techniques; Ketotifen; Leukotriene B4; Male; Mast Cells; Pepsin A; Peptide Fragments; Platelet Activating Factor; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; SRS-A; Substance P; Triazoles | 1991 |
Pharmacological characterization of tachykinin-stimulated inositol phospholipid hydrolysis in peripheral tissues.
Topics: Animals; Cricetinae; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Muscles; Parotid Gland; Peptide Fragments; Peptides, Cyclic; Phosphatidylinositols; Pyrrolidonecarboxylic Acid; Rats; Substance P; Tachykinins; Urinary Bladder | 1990 |
Evidence for dose-dependent positively and negatively reinforcing effects of the substance P C-terminal analog DIME-C7.
Topics: Animals; Dose-Response Relationship, Drug; Male; Motor Activity; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Substance P | 1990 |
Neurochemical consequences following injection of the substance P analogue, DiMe-C7, into the rat ventral tegmental area.
Topics: Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Extrapyramidal Tracts; Female; Indoles; Injections; Limbic System; Motor Activity; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Substance P; Tegmentum Mesencephali | 1990 |
The possibility of participation of different protein kinases in the regulation of degradation of Glp6[125I]Tyr8SP6-11 with different endopeptidases in subcellular fractions of rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Brain; Cell Nucleus; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic GMP; Endopeptidases; Hippocampus; Neurotransmitter Agents; Peptide Fragments; Protease Inhibitors; Protein Kinases; Pyrrolidonecarboxylic Acid; Rats; Second Messenger Systems; Subcellular Fractions; Substance P; Synaptosomes; Tetradecanoylphorbol Acetate | 1991 |
The effect of the typical peptidases (proteases) inhibitors on the degradation of Glp6 (125I) Tyr8SP6-11 hexapeptide in the nuclear and synaptosomal fraction of the cortex and hippocampus of rat brain.
Topics: Animals; Cell Nucleus; Cerebral Cortex; Hippocampus; Iodine Radioisotopes; Kinetics; Peptide Fragments; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Rats; Substance P; Synaptosomes; Tritium | 1990 |
Intranigral tachykinin NK3 receptor agonist elicits oral movements in rats.
Topics: Animals; Female; Infusions, Parenteral; Mastication; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachykinins | 1991 |
Acute and chronic effects of intrathecal galanin on behavioural and biochemical markers of spinal motor function in adult rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain Stem; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Galanin; Hydroxyindoleacetic Acid; Hypothalamus; Injections, Spinal; Insulin; Male; Methoxydimethyltryptamines; Motor Activity; Muscle Contraction; Peptides; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P; Thyrotropin-Releasing Hormone | 1991 |
Synthesis and biological activity of substance P C-terminal hexapeptide and heptapeptide analogues.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Peptide Fragments; Portal Vein; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vas Deferens | 1991 |
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Substance P; Vas Deferens | 1991 |
Tachykinin receptors in the guinea-pig isolated bronchi.
Topics: Amino Acid Sequence; Animals; Bronchi; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Neurokinin A; Oligopeptides; Peptide Fragments; Phenoxybenzamine; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Differential effects of substance P analogs on neurokinin 1 receptor agonists in the mouse spinal cord.
Topics: Analgesics; Animals; Behavior, Animal; Injections, Spinal; Male; Mice; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Spinal Cord; Substance P | 1991 |
Backbone cyclization: A new method for conferring conformational constraint on peptides.
Topics: Amino Acid Sequence; Cyclization; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Conformation; Pyrrolidonecarboxylic Acid; Substance P | 1991 |
Multiple neurokinin receptor subtypes are present in the colon of the cat and rat.
Topics: Animals; Atropine; Cats; Colon; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1991 |
Species differences between [3H] substance P binding in rat and guinea-pig shown by the use of peptide agonists and antagonists.
Topics: Animals; Brain Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Peptide Fragments; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Tachykinin; Species Specificity; Substance P; Tachykinins | 1991 |
Synthesis of a potent agonist of substance P by modifying the methionyl and glutaminyl residues of the C-terminal hexapeptide of substance P. Structure-activity relationships.
Topics: Amino Acid Sequence; Animals; Biological Assay; Colon; Glutamine; Guinea Pigs; Ileum; Methionine; Molecular Sequence Data; Peptide Fragments; Portal Vein; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1991 |
Cardiovascular effects of spinal cord substance P: studies with a stable receptor agonist.
Topics: Animals; Cardiovascular System; Dose-Response Relationship, Drug; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P; Sympathetic Nervous System | 1985 |
Effects of analogues of substance P fragments on the MAO activity in rat brain.
Topics: Animals; Brain; In Vitro Techniques; Male; Mitochondria; Monoamine Oxidase; Nerve Tissue Proteins; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P | 1985 |
LH-RH analogue acts as substance P antagonist by inhibiting spinal cord vasomotor responses.
Topics: Animals; Blood Pressure; Efferent Pathways; Gonadotropin-Releasing Hormone; Heart Rate; Male; Medulla Oblongata; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Vasomotor System | 1985 |
The preliminary evaluation of degradation of substance P(SP) fragment's analogue less than Glu SP6-11 in the subcellular fractions from different areas of rat brain.
Topics: Animals; Biotransformation; Brain; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Oligopeptides; Peptide Fragments; Peptide Hydrolases; Pyrrolidonecarboxylic Acid; Rats; RNA; Subcellular Fractions; Substance P | 1985 |
Desensitization of substance P-induced K+ release in rat parotid.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Parasympatholytics; Parotid Gland; Peptide Fragments; Potassium; Pyrrolidonecarboxylic Acid; Rats; Receptors, Adrenergic, alpha; Stimulation, Chemical; Substance P; Time Factors | 1985 |
[Synthesis of cyclic and non-cyclic tachykinin partial sequences. 2. Synthesis of the homocyclic substance P(6-11) hexapeptide].
Topics: Amino Acid Sequence; Animals; Cyclization; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1985 |
Arterial blood pressure response in conscious rabbits to administration of C-terminal fragment of substance P into the cerebral ventricles, intravenously and intragastrically.
Topics: Analgesics; Animals; Blood Pressure; Female; Injections; Injections, Intravenous; Injections, Intraventricular; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Stomach; Substance P | 1985 |
Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area.
Topics: Animals; Corpus Striatum; Dopamine; Frontal Lobe; Limbic System; Male; Mesencephalon; Neural Pathways; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Synaptic Transmission | 1986 |
Water intake modifications induced by tachykinins, bombesins and opioid peptides.
Topics: Angiotensin II; Animals; Bombesin; Columbidae; Drinking Behavior; Eledoisin; Endorphins; Enkephalins; Nerve Tissue Proteins; Oligopeptides; Opioid Peptides; Physalaemin; Pyrrolidonecarboxylic Acid; Rats; Substance P; Tachykinins; Vasopressins; Water-Electrolyte Balance | 1985 |
Behavioural effects of tachykinins and related peptides.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Eledoisin; Grooming; Injections, Intraventricular; Male; Motor Activity; Neuropeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Tachykinins; Tegmentum Mesencephali | 1986 |
Regulation of surfactant secretion from isolated Type II pneumocytes by substance P.
Topics: Animals; Lung; Peptide Fragments; Physalaemin; Pulmonary Surfactants; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Terbutaline; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurons; Oligopeptides; Parotid Gland; Peptide Fragments; Potassium; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1986 |
Synthesis of (pGlu-5, MePhe-8, Sar-9) substance P (5-11) (DiMe-C7) using a polyacrylamide resin and biological activity on guinea pig ileum and tracheal smooth muscle.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1987 |
Substance-P antagonists: effect on spontaneous and drug-induced locomotor activity in the rat.
Topics: Animals; Brain; Dopamine; Injections, Intraventricular; Male; Motor Activity; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P | 1987 |
Effect of the 5-HT3 receptor antagonist, GR38032F, on responses to injection of a neurokinin agonist into the ventral tegmental area of the rat brain.
Topics: Animals; Dopamine; Imidazoles; Injections; Male; Motor Activity; Nucleus Accumbens; Ondansetron; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Substance P; Tegmentum Mesencephali | 1987 |
Effect of substance P on rat gastrointestinal transit.
Topics: Animals; Gastrointestinal Transit; Hydroxylamines; Male; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1988 |
Behavioural effects of receptor-specific substance P agonists.
Topics: Animals; Behavior, Animal; Injections, Spinal; Male; Muscle Hypotonia; Pain Measurement; Paralysis; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Nerve Roots; Stereotyped Behavior; Substance P | 1987 |
The effects of the main body cations on the peptidase(s) activity against pyroGlu6[125I-Tyr8]SP6-11 in the nuclear and synaptosomal fraction of the cortex and hippocampus of rat brain.
Topics: Animals; Calcium; Cations; Cell Nucleus; Cerebral Cortex; Female; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Magnesium; Male; Osmolar Concentration; Peptide Fragments; Peptide Hydrolases; Potassium; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sodium; Substance P; Synaptosomes | 1987 |
Regional peripheral and CNS hemodynamic effects of intrathecal administration of a substance P receptor agonist.
Topics: Animals; Blood Pressure; Cardiac Output; Cerebrovascular Circulation; Heart Rate; Hemodynamics; Injections, Spinal; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Regional Blood Flow; Spinal Cord; Stroke Volume; Substance P; Vascular Resistance | 1987 |
N-acylated pentapeptides antagonists of substance P on guinea-pig ileum.
Topics: Acylation; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Substance P | 1988 |
Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion.
Topics: Animals; Avoidance Learning; Injections, Intraventricular; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P | 1988 |
Effect of intrathecal proctolin administration on the behaviour evoked by the thyrotrophin-releasing hormone (TRH) analogue (RX 77368) and the indoleamine, TRH, substance P and calcitonin gene-related peptide levels and choline acetyltransferase activity
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Choline O-Acetyltransferase; Drug Interactions; Hydroxyindoleacetic Acid; Injections, Spinal; Male; Neuropeptides; Neurotransmitter Agents; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P; Thyrotropin-Releasing Hormone | 1988 |
Intra-raphe neurokinin-induced hyperactivity: effects of 5,7-dihydroxytryptamine lesions.
Topics: 5,7-Dihydroxytryptamine; Action Potentials; Animals; Catecholamines; Dihydroxytryptamines; Male; Medial Forebrain Bundle; Motor Activity; Neural Pathways; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1989 |
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins.
Topics: Animals; Captopril; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Substance P; Tachykinins; Thiorphan | 1989 |
Effect of age and methacholine on the rate and coronary flow of isolated hearts of diabetic rats.
Topics: Aging; Animals; Atropine; Blood Glucose; Body Weight; Coronary Circulation; Diabetes Mellitus, Experimental; Heart; Heart Rate; In Vitro Techniques; Male; Methacholine Compounds; Organ Size; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Time Factors | 1989 |
Effects of receptor-selective neurokinin agonists and a neurokinin antagonist on the electrical activity of spinal cord neurones in culture.
Topics: Animals; Cells, Cultured; Electrophysiology; Female; Glutamates; Membrane Potentials; Microelectrodes; Neurons; Peptide Fragments; Pregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P; Tetrodotoxin | 1989 |
Further studies on the motor response of the human isolated urinary bladder to tachykinins, capsaicin and electrical field stimulation.
Topics: Adult; Aged; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Tachykinins; Thiorphan; Urinary Bladder | 1989 |
Intrathecal substance P and galanin attenuate TRH analogue-induced wet-dog shake behaviour.
Topics: Animals; Galanin; Injections, Spinal; Male; Motor Activity; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Thyrotropin-Releasing Hormone | 1989 |
Substance P analogues containing D-histidine antagonize the behavioural effects of intrathecally co-administered substance P in mice.
Topics: Amino Acid Sequence; Animals; Avoidance Learning; Behavior, Animal; Histidine; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Peptide Fragments; Peptides; Psychomotor Performance; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Substance P; Tachykinins | 1989 |
Substance P antagonists block carbachol-induced "boxing" behavior at a site of coexistence in the rat prefrontal cortex.
Topics: Amino Acid Sequence; Animals; Carbachol; Male; Microinjections; Molecular Sequence Data; Motor Activity; Neurotransmitter Agents; Peptide Fragments; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Substance P | 1988 |
NH resonances of Ribonuclease S-peptide in aqueous solution. Low temperature n.m.r. study.
Topics: Amides; Cold Temperature; Magnetic Resonance Spectroscopy; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Ribonucleases; Solutions; Substance P | 1985 |
Specificity of antisera obtained to substance P and its C-terminal hexapeptide.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Binding, Competitive; Epitopes; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Serum Albumin, Bovine; Substance P | 1985 |
Locomotor activation induced in rodent by substance P and analogues. Blockade of the effect of substance P by met-enkephalin antiserum.
Topics: Animals; Enkephalin, Methionine; Immune Sera; Male; Mice; Mice, Inbred ICR; Motor Activity; Naloxone; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P | 1984 |
The pressor response to substance P and hexapeptide [pGlu6]SP 6--11 injections into the cerebral ventricles in rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Propranolol; Pyrrolidonecarboxylic Acid; Rats; Substance P; Synaptic Transmission; Time Factors; Vagotomy | 1980 |
Substance P, hexapeptide pGlu6(SP6-11), analgesia and serotonin depletion.
Topics: Analgesics; Animals; Fenclonine; Injections, Intraventricular; Male; Mice; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Serotonin; Substance P | 1981 |
Persistent action of N-methylated analogs of substance P on rat parotid slices.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Parotid Gland; Peptide Fragments; Peptide Hydrolases; Potassium; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1981 |
Effect of substance P and its C-terminal hexapeptide on gastric and pancreatic secretion in the dog.
Topics: Animals; Bicarbonates; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Duodenum; Gastric Juice; Heart Rate; Hydrogen-Ion Concentration; Kinetics; Pancreatic Juice; Peptide Fragments; Proteins; Pyrrolidonecarboxylic Acid; Substance P | 1981 |
Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P.
Topics: Animals; Bombesin; Dogs; Food; Gastric Acid; Gastrins; Kinetics; Oligopeptides; Pancreatic Polypeptide; Peptide Fragments; Peptides; Pyrrolidonecarboxylic Acid; Substance P | 1981 |
Extinction of hippocampal theta rhythm evoked by mid-brain stimulation after intracerebroventricular administration of substance P fragment and enkephalin administration in rabbits.
Topics: Animals; Electric Conductivity; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hippocampus; Kinetics; Mesencephalon; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Substance P; Theta Rhythm | 1981 |
Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions.
Topics: Animals; Behavior, Animal; Brain; Motor Activity; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1982 |
Presence of ranatensin-like and bombesin-like peptides in amphibian brains.
Topics: Animals; Bombesin; Brain; Fluorescent Antibody Technique; Gastric Mucosa; Histocytochemistry; Neurons; Oligopeptides; Peptides; Physalaemin; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Rana catesbeiana; Rana pipiens; Skin; Substance P; Tissue Distribution; Xenopus laevis | 1982 |
Synthesis and metabolic stability of a tritium-labelled substance P analogue.
Topics: Animals; Biological Assay; Cross Reactions; Drug Stability; Guinea Pigs; Ileum; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Radioisotope Dilution Technique; Substance P; Tritium | 1982 |
The behavioural effects of a novel substance P analogue following infusion into the ventral tegmental area or substantia nigra of rat brain.
Topics: Animals; Behavior, Animal; Male; Motor Activity; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1982 |
Conformational studies on substance P. C-terminal pentapeptide pGlu-Phe-Phe-Gly-Leu-Met NH2.
Topics: Amino Acid Sequence; Animals; Oligopeptides; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Substance P | 1982 |
A comparison of the release of substance P and some synthetic analogues from micropipettes by microiontophoresis or pressure.
Topics: Electrophoresis; Iontophoresis; Peptide Fragments; Pressure; Pyrrolidonecarboxylic Acid; Substance P | 1983 |
Substance P-induced release of Met5-enkephalin from striatal and periaqueductal gray slices.
Topics: Animals; Arginine Vasopressin; Bombesin; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Naloxone; Neurotensin; Nociceptors; Peptide Fragments; Periaqueductal Gray; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P | 1983 |
Vascular protein linkage in various tissue induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge.
Topics: Animals; Antigens; Blood Proteins; Bradykinin; Capillary Permeability; Capsaicin; Guinea Pigs; Histamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1983 |
Influence of substance P and fragments on passive avoidance behavior.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Mice; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1984 |
Substance P degrading systems of rat parotid and hypothalamus.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Hypothalamus; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Oligopeptides; Parotid Gland; Peptide Fragments; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1984 |
Micromolar substance P reduces spinal receptor binding for thyrotropin-releasing hormone--possible relevance to neuropeptide coexistence?
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Efferent Pathways; Pyrrolidonecarboxylic Acid; Radioligand Assay; Raphe Nuclei; Rats; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1983 |
Immunogenic and antigenic properties of the COOH-terminal hexapeptide of substance P.
Topics: Animals; Epitopes; Immune Sera; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Radioimmunoassay; Substance P | 1984 |
3H-substance P binding to guinea-pig ileum longitudinal smooth muscle membranes.
Topics: Animals; Binding, Competitive; Cell Membrane; Eledoisin; Guinea Pigs; Ileum; Male; Muscle Contraction; Peptide Fragments; Phosphatidylinositols; Pyrrolidonecarboxylic Acid; Substance P; Tritium | 1984 |
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Parallel bioassay of PG-SPI, an amphibian acidic SP-like peptide, mammalian basic substance P, and neurokinins A and B on in vitro and in vivo test systems.
Topics: Amino Acid Sequence; Animals; Biological Assay; Biphenyl Compounds; Cricetinae; Evaluation Studies as Topic; Gastric Mucosa; Guinea Pigs; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Oligopeptides; Organ Culture Techniques; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Ranidae; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P | 1995 |
Long-term effects of small bowel transplantation on intestinal motility.
Topics: Analgesics; Animals; Atropine; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Lew; Reference Values; Substance P; Surgical Flaps; Tetrodotoxin; Time Factors; Transplantation, Isogeneic | 1995 |
Tachykinin NK1 receptors mediate both vasoconstrictor and vasodilator responses in the rabbit isolated jugular vein.
Topics: Animals; Dose-Response Relationship, Drug; Endothelium; Jugular Veins; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Tachykinin; Substance P; Tachykinins; Vasoconstriction; Vasodilation | 1995 |
Intra-VTA infusions of the substance P analogue, DiMe-C7, and intra-accumbens infusions of amphetamine induce analgesia in the formalin test for tonic pain.
Topics: Amphetamine; Analgesia; Animals; Dopamine; Infusions, Parenteral; Male; Microinjections; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Substance P; Ventral Tegmental Area | 1993 |
Septide: an agonist for the NK1 receptor acting at a site distinct from substance P.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Indoles; Inositol Phosphates; Isoindoles; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioligand Assay; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Transfection | 1994 |
Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Structure, Secondary; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Transfection | 1994 |
SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
Topics: Astrocytoma; Binding, Competitive; Calcium; Electric Conductivity; Genes, fos; Humans; Inositol Phosphates; Iodine Radioisotopes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Succinimides; Taurine; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Evidence for tachykinin NK-2 receptors in guinea-pig airways from binding and functional studies, using [125I]-[Lys5,Tyr(I2)7,MeLeu9,Nle10]-NKA(4-10).
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Bronchi; Drug Interactions; Female; Guinea Pigs; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Peptide Fragments; Protease Inhibitors; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Substance P; Tachykinins | 1994 |
In vivo evidence for the activation of a septide-sensitive tachykinin receptor in guinea pig bronchoconstriction.
Topics: Animals; Biphenyl Compounds; Bronchial Spasm; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Hypnotics and Sedatives; Male; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Substance P; Sulfones | 1994 |
Tachykinin NK1 receptor subtypes in the rat urinary bladder.
Topics: Animals; Benzamides; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Sulfones; Tachykinins; Urinary Bladder | 1994 |
Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon.
Topics: Animals; Colon; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones | 1994 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
The involvement of sympathetic nerves in plasma extravasation induced by prostaglandin E2 and substance P.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Capillary Permeability; Dinoprostone; Guanethidine; Indomethacin; Male; Molecular Sequence Data; Norepinephrine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Substance P; Sympathetic Nervous System | 1994 |
Different susceptibility to neurokinin 1 receptor antagonists of substance P and septide-induced interleukin-6 release from U373 MG human astrocytoma cell line.
Topics: Astrocytoma; Binding, Competitive; Brain Neoplasms; Humans; Interleukin-6; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Tumor Cells, Cultured | 1994 |
Septide but not substance P stimulates inhibitory neurons in guinea-pig ileum.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P | 1994 |
Highly potent substance P antagonists substituted with beta-phenyl- or beta-benzyl-proline at position 10.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1994 |
Typical and atypical NK1 tachykinin receptor characteristics in the rabbit isolated iris sphincter.
Topics: Animals; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phenoxybenzamine; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 1994 |
Use of selective antagonists for further characterization of tachykinin NK-2, NK-1 and possible "septide-selective" receptors in guinea pig bronchus.
Topics: Amino Acid Sequence; Animals; Bronchi; Female; Guinea Pigs; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Substance P; Tachykinins | 1994 |
Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1994 |
Distinct heterotrimeric GTP-binding-proteins act in series to control the exocytotic machinery in chromaffin cells.
Topics: Adenosine Triphosphate; Aluminum Compounds; Amino Acid Sequence; Animals; Calcium; Cattle; Chromaffin System; Exocytosis; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Norepinephrine; Oligopeptides; Peptides; Protein Conformation; Pyrrolidonecarboxylic Acid; Substance P; Wasp Venoms | 1994 |
Comparison of antagonistic effects of sendide and CP-96,345 on a spinally mediated behavioural response in mice.
Topics: Analgesics; Animals; Behavior, Animal; Biphenyl Compounds; Hypnotics and Sedatives; Injections; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Peptide Fragments; Postural Balance; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spinal Cord; Subarachnoid Space; Substance P | 1994 |
Pressor responses to electrical and chemical stimulation of the rat brain A10 dopaminergic system.
Topics: Animals; Benzazepines; Blood Pressure; Brain; Dopamine; Electric Stimulation; Haloperidol; Heart Rate; Male; Microinjections; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Substance P; Ventral Tegmental Area | 1994 |
The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test.
Topics: Animals; Behavior, Animal; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1995 |
Synthesis of potent agonists of substance P by replacement of Met11 with Glu(OBzl) and N-terminal glutamine with Glp of the C-terminal hexapeptide and heptapeptide of substance P.
Topics: Amino Acid Sequence; Animals; Biological Assay; Glutamine; Guinea Pigs; Methionine; Molecular Sequence Data; Muscle, Smooth; Muscle, Smooth, Vascular; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Conformational study of two substance P hexapeptides by two-dimensional NMR.
Topics: Amino Acid Sequence; Chloroform; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein Folding; Pyrrolidonecarboxylic Acid; Solvents; Stereoisomerism; Substance P; Trifluoroethanol; Water | 1993 |
Electrophysiological effects of tachykinin analogues on ganglion cell activity in cyprinid fish retina.
Topics: Action Potentials; Animals; Cyprinidae; Eledoisin; Neurokinin A; Peptide Fragments; Physalaemin; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Tachykinin; Retinal Ganglion Cells; Species Specificity; Substance P; Tachykinins | 1993 |
Attenuated plasma extravasation to sensory neuropeptides in diabetic rats.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capillary Permeability; Diabetes Mellitus, Experimental; Male; Molecular Sequence Data; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Serum Albumin; Substance P | 1993 |
Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1993 |
Synthesis, biological activity, and conformational analysis of [pGlu6,N-MePhe8,Aib9] substance P (6-11): a selective agonist for the NK-3 receptor.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1993 |
Scratching behavior induced by bombesin-related peptides. Comparison of bombesin, gastrin-releasing peptide and phyllolitorins.
Topics: Amino Acid Sequence; Animals; Bombesin; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Gastrin-Releasing Peptide; Grooming; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin B; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Structure-Activity Relationship; Substance P | 1993 |
Effect of substance P on the expression of an adhesion molecule ICAM-1 in human vascular endothelial cells.
Topics: Antibodies, Monoclonal; Cell Adhesion Molecules; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Kinetics; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Umbilical Veins; Vascular Cell Adhesion Molecule-1; von Willebrand Factor | 1993 |
Mechanism for substance P-induced activation of human neutrophils and eosinophils.
Topics: Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophils; Humans; In Vitro Techniques; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Superoxides | 1993 |
Variations in affinities for the NK1 receptor: differences between the non-peptide substance P antagonists RP 67580 and CP-96,345 and the agonist septide.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Cell Line; Dogs; Guinea Pigs; Humans; Indoles; Isoindoles; Mice; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Submandibular Gland; Substance P | 1993 |
A selective and extremely potent antagonist of the neurokinin-1 receptor.
Topics: Analgesics; Animals; Behavior, Animal; Cell Membrane; Dose-Response Relationship, Drug; Injections, Spinal; Kinetics; Mice; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1993 |
Neuromodulation mediated by neurokinin-1 subtype receptors in adult rabbit airways.
Topics: Acetylcholine; Animals; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nervous System Physiological Phenomena; Parasympathetic Nervous System; Peptide Fragments; Physalaemin; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 1993 |
Altered vascular permeability responses to substance P in diabetic rats: interactions with a nitric oxide synthesis inhibitor.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Glucose; Blood Pressure; Capillary Permeability; Diabetes Mellitus, Experimental; Dinoprostone; Drinking; Injections, Intravenous; Male; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Substance P | 1993 |
Demonstration of a 'septide-sensitive' inflammatory response in rat skin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Dermatitis, Contact; Dose-Response Relationship, Drug; Edema; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Comparative behavioural profile of centrally administered tachykinin NK1, NK2 and NK3 receptor agonists in the guinea-pig.
Topics: Animals; Behavior, Animal; Guinea Pigs; Injections, Intraventricular; Male; Motor Activity; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Substance P hyperpolarizes vagal sensory neurones of the ferret.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Benzamides; Biphenyl Compounds; Cations, Divalent; Cesium; Electrophysiology; Ferrets; In Vitro Techniques; Male; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quaternary Ammonium Compounds; Receptors, Tachykinin; Substance P; Vagus Nerve | 1996 |
Reinforcing properties of the substance P C-fragment analog DiMe-C7 in Carassius auratus.
Topics: Animals; Behavior, Animal; Goldfish; Peptide Fragments; Pyrrolidonecarboxylic Acid; Reinforcement, Psychology; Substance P | 1996 |
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists.
Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P | 1996 |
Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; Molecular Sequence Data; Muscle, Smooth; Peptide Fragments; Peptides, Cyclic; Protein Binding; Protein Conformation; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1996 |
Distinct regulations by septide and the neurokinin-1 tachykinin receptor agonist [pro9]substance P of the N-methyl-D-aspartate-evoked release of dopamine in striosome- and matrix-enriched areas of the rat striatum.
Topics: Animals; Corpus Striatum; Dopamine; Extracellular Matrix; Indoles; Isoindoles; Male; N-Methylaspartate; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P | 1996 |
Neurokinin subtype receptors mediating substance P contraction in immature rabbit airways.
Topics: Animals; Atropine; Bronchi; Glycopeptides; Isometric Contraction; Muscle, Smooth; Neostigmine; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1996 |
Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat.
Topics: Animals; Benzamides; Blood Pressure; Guinea Pigs; Hypotension; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Neurokinin A; Neurokinin B; Nitric Oxide; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea | 1996 |
Lack of a role for substance P in the control of dural arterial flow.
Topics: Animals; Cerebral Arteries; Dura Mater; Electric Stimulation; Indoles; Isoindoles; Laser-Doppler Flowmetry; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Regional Blood Flow; Substance P | 1996 |
Stimulation of the rat mesolimbic dopaminergic system produces a pressor response which is mediated by dopamine D-1 and D-2 receptor activation and the release of vasopressin.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Ganglionic Blockers; Injections; Limbic System; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stimulation, Chemical; Substance P; Substantia Nigra; Vasopressins; Ventral Tegmental Area | 1995 |
Neurokinin receptors in the guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Regional expression of c-fos in rat brain following stimulation of the ventral tegmental area.
Topics: Animals; Blood Pressure; Brain Mapping; Electric Stimulation; Heart Rate; Hypothalamus; Limbic System; Male; Peptide Fragments; Proto-Oncogene Proteins c-fos; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Substance P; Tegmentum Mesencephali | 1996 |
Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; COS Cells; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P | 1996 |
Organization of the stomatogastric neuropil of the crab, Cancer borealis, as revealed by modulator immunocytochemistry.
Topics: Animals; Brachyura; Cholecystokinin; Fluorescent Antibody Technique, Indirect; Ganglia, Invertebrate; Neuropeptides; Neurotransmitter Agents; Oligopeptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Serotonin; Substance P | 1997 |
The NK1 receptor and its participation in the synergistic enhancement of corneal epithelial migration by substance P and insulin-like growth factor-1.
Topics: Animals; Cell Movement; Cornea; Drug Synergism; Epithelium; Insulin-Like Growth Factor I; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Substance P | 1997 |
Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1996 |
Substance P in the dorsal vagal complex inhibits medullary TRH-induced gastric acid secretion in rats.
Topics: Animals; Biphenyl Compounds; Cerebral Ventricles; Gastric Acid; Kainic Acid; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Substance P; Thyrotropin-Releasing Hormone; Vagus Nerve | 1997 |
Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen granules is involved in calcium-regulated amylase secretion.
Topics: Amylases; Animals; Calcium; Cytoplasmic Granules; Enzyme Precursors; Fluorescent Antibody Technique; GTP Phosphohydrolases; GTP-Binding Proteins; Microscopy, Fluorescence; Oligopeptides; Pancreas; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Rats; Substance P | 1997 |
Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea.
Topics: Animals; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Fragments; Physalaemin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea | 1997 |
High affinity binding of [3H]propionyl-[Met(O2)11]substance P(7-11), a tritiated septide-like peptide, in Chinese hamster ovary cells expressing human neurokinin-1 receptors and in rat submandibular glands.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Submandibular Gland; Substance P | 1997 |
Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder.
Topics: Analgesics; Animals; Benzamides; Binding Sites; Inositol Phosphates; Male; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins; Tritium; Type C Phospholipases; Urinary Bladder | 1997 |
A functional interaction between the mesolimbic dopamine system and vasopressin release in the regulation of blood pressure in conscious rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Consciousness; Denervation; Dopamine; Dopamine Antagonists; Heart Rate; Male; Microinjections; Peptide Fragments; Proto-Oncogene Proteins c-fos; Pyrrolidonecarboxylic Acid; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides; Stimulation, Chemical; Substance P; Supraoptic Nucleus; Vasopressins; Ventral Tegmental Area | 1997 |
Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum.
Topics: Animals; Electric Stimulation; Female; Ganglia, Autonomic; Guinea Pigs; Ileum; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Male; Membrane Potentials; Microscopy, Video; Muscle, Smooth; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurokinin-1; Submucous Plexus; Substance P; Vasodilation | 1997 |
Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Male; N-Methylaspartate; Neurokinin A; Pain; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Sulfonamides | 1997 |
A "septide-sensitive" receptor is not involved in tachykinin-mediated secretory and inositol phosphate responses in rat parotid gland: are several transduction pathways involved after the stimulation of the NK1 receptor?
Topics: Animals; Cells, Cultured; Indoles; Inositol Phosphates; Isoindoles; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Parotid Gland; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Salivary Proteins and Peptides; Signal Transduction; Substance P; Tachykinins | 1998 |
Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions.
Topics: Amphetamine; Analgesics, Non-Narcotic; Animals; Central Nervous System Stimulants; Formaldehyde; Male; Microinjections; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 1997 |
Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition.
Topics: Animals; Baclofen; Bicuculline; Entorhinal Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Phosphinic Acids; Propanolamines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Receptors, GABA-B; Substance P; Synapses; Tachykinins | 1998 |
Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine.
Topics: Adrenergic Antagonists; Amphetamine; Analgesia; Analgesics, Opioid; Animals; Benzazepines; Dopamine Antagonists; Flupenthixol; Male; Morphine; Nucleus Accumbens; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raclopride; Rats; Rats, Wistar; Salicylamides; Substance P; Ventral Tegmental Area | 1998 |
The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro.
Topics: Animals; Anti-Anxiety Agents; Gerbillinae; In Vitro Techniques; Motor Neurons; Neurokinin-1 Receptor Antagonists; Neuromuscular Depolarizing Agents; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinolines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1998 |
Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.
Topics: Animals; Calcium; Colon; Enteric Nervous System; Guinea Pigs; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Tachykinin; Substance P; Tachykinins | 1998 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction.
Topics: Acetylcholinesterase; Animals; Calcium; GTP-Binding Proteins; Muscarine; Muscle, Skeletal; Neostigmine; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rana pipiens; Receptors, Neurokinin-1; Schwann Cells; Substance P; Synapses; Virulence Factors, Bordetella | 1998 |
Point mutation increases a form of the NK1 receptor with high affinity for neurokinin A and B and septide.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Neurokinin A; Neurokinin B; Peptide Fragments; Point Mutation; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1998 |
Antiemetic effects of sendide, a peptide tachykinin NK1 receptor antagonist, in the ferret.
Topics: Animals; Antiemetics; Cisplatin; Ferrets; Ileum; In Vitro Techniques; Male; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Serotonin; Substance P; Vagus Nerve | 1998 |
Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-D-aspartate- and septide-induced nociceptive behaviour.
Topics: Analgesics; Animals; Bupivacaine; Imidazoles; Male; Morphine; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P | 1998 |
Rat gastrointestinal motor responses mediated via activation of neurokinin receptors.
Topics: Animals; Chromates; Chromium Radioisotopes; Gastric Emptying; Gastrointestinal Motility; Intubation, Gastrointestinal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sodium Compounds; Substance P | 1999 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Identification in the NK1 tachykinin receptor of a domain involved in recognition of neurokinin A and septide but not of substance P.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Chlorocebus aethiops; COS Cells; DNA, Complementary; Humans; In Vitro Techniques; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Point Mutation; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Tachykinins | 1999 |
Opioid activity of sendide, a tachykinin NK1 receptor antagonist.
Topics: Analgesics; Animals; Behavior, Animal; Bombesin; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Opioid; Substance P | 1999 |
Reinforcing effects of neurokinin substance P in the ventral pallidum: mediation by the tachykinin NK1 receptor.
Topics: Androstanes; Animals; Behavior, Animal; Benzimidazoles; Brain; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 1999 |
Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat.
Topics: Acetamides; Animals; Behavior, Animal; Blood Pressure; Capillary Permeability; Heart Rate; Indoles; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1999 |
Central tachykinin NK3 receptors in the inhibitory action on the rat colonic propulsion of a new tachykinin, PG-KII.
Topics: Animals; Colon; Gastrointestinal Transit; Injections, Intraventricular; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1999 |
Quantitative analysis of pyroglutamic acid in peptides.
Topics: Amphibian Proteins; Bacillus; Bombesin; Chromatography, High Pressure Liquid; Gastrins; Gonadotropin-Releasing Hormone; Hormones; Humans; Peptide Hormones; Peptides; Pyrococcus; Pyroglutamyl-Peptidase I; Pyrrolidonecarboxylic Acid; Substance P; Thyrotropin-Releasing Hormone | 1999 |
Hyperthyroidism decreases thyrotropin-releasing hormone gene expression in the caudal raphe nuclei and the parapyramidal regions in rats.
Topics: Animals; Gene Expression; Hyperthyroidism; Male; Medulla Oblongata; Protein Precursors; Pyramidal Tracts; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Thyroidectomy; Thyrotropin-Releasing Hormone; Thyroxine | 1999 |
Stimulation of the ventral tegmental area enhances the effect of vasopressin on blood pressure in conscious rats.
Topics: Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Male; Methoxamine; Microinjections; Neurotensin; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Stimulation, Chemical; Substance P; Vasoconstrictor Agents; Vasopressins; Ventral Tegmental Area | 2000 |
Role of nitric oxide and septide-insensitive NK(1) receptors in bronchoconstriction induced by aerosolised neurokinin A in guinea-pigs.
Topics: Aerosols; Airway Resistance; Animals; Bronchoconstriction; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 2000 |
Role of substance P in central control of ovulation in female rats.
Topics: Animals; Capsaicin; Cerebral Ventricles; Enkephalin, Methionine; Epinephrine; Female; Gonadotropin-Releasing Hormone; Homeostasis; Ovulation; Peptide Fragments; Pseudopregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred BUF; Rats, Wistar; Substance P | 1999 |
Pretreatment with fragments of substance-P or with cholecystokinin differentially affects recovery from sub-total nigrostriatal 6-hydroxydopamine lesion.
Topics: Animals; Corpus Striatum; Dopamine; Functional Laterality; Male; Motor Activity; Oxidopamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Substance P; Substantia Nigra; Tetragastrin | 1999 |
Further evidence for the presence of "septide-sensitive" tachykinin binding sites in tissues possessing solely NK(1) tachykinin receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Humans; Indoles; Iodine Radioisotopes; Isoindoles; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protein Isoforms; Pyrrolidonecarboxylic Acid; Radioligand Assay; Rats; Receptors, Neurokinin-1; Substance P; Tetrazoles; Tumor Cells, Cultured | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Evidence for functional NK1-tachykinin receptors on motor neurones supplying the circular muscle of guinea-pig small and large intestine.
Topics: Animals; Colon; Duodenum; Enzyme Inhibitors; Guinea Pigs; Ileum; Immunohistochemistry; In Vitro Techniques; Indomethacin; Motor Neurons; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P | 2000 |
Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Time Factors | 2000 |
Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Behavior, Animal; Calcium; Calcium-Transporting ATPases; Dantrolene; Enzyme Inhibitors; Male; Muscle Relaxants, Central; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Thapsigargin | 2001 |
Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.
Topics: Adult; Biphenyl Compounds; Calcium; Calcium Channels; Calcium Signaling; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Humans; Interleukin-8; Ion Transport; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Substance P | 2001 |
Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus.
Topics: Animals; Antiemetics; Brain Stem; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; Neurokinin A; Patch-Clamp Techniques; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Presynaptic; Substance P; Tetrodotoxin; Vagus Nerve | 2001 |
Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiemetics; Dose-Response Relationship, Drug; Guinea Pigs; Locus Coeruleus; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Peptide Fragments; Piperidines; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tetrazoles | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Aminopeptidases in Caenorhabditis elegans and Panagrellus redivivus: detection using peptide and non-peptide substrates.
Topics: Amino Acids; Aminopeptidases; Animals; Anti-Bacterial Agents; Caenorhabditis elegans; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Insect Hormones; Nematoda; Oligopeptides; Peptides; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Species Specificity; Substance P | 2002 |
Spinal nociceptin inhibits septide but not N-methyl-D-aspartate-induced nociceptive behavior in rats.
Topics: Animals; Behavior, Animal; Injections, Spinal; Male; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord; Substance P | 2002 |
Selective tachykinin NK3-receptor agonists stimulate in vitro exocrine pancreatic secretion in the guinea pig.
Topics: Amylases; Animals; Atropine; Carbachol; Ceruletide; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Pancreas; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-3; Substance P; Substrate Specificity; Tachykinins | 2002 |
Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indoles; Injections, Spinal; Isoindoles; Male; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P | 2003 |
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.
Topics: Alanine; Animals; Atropine; Colon; Drug Interactions; Enzyme Inhibitors; Indoles; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peristalsis; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Substance P | 2003 |
Biologic activity of the tachykinins on lamb and sheep gallbladder.
Topics: Animals; Binding Sites; Capsaicin; Dose-Response Relationship, Drug; Female; Gallbladder; Male; Muscles; Neurokinin A; Neurokinin B; Peptide Fragments; Physalaemin; Protein Structure, Tertiary; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Sheep; Substance P; Tachykinins | 2003 |
GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex.
Topics: Animals; Animals, Newborn; Axons; Calbindin 2; Calbindins; Cell Count; Cerebral Cortex; Cholera Toxin; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunoenzyme Techniques; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Isoenzymes; Male; Membrane Potentials; Neurons; Neuropeptide Y; Parvalbumins; Patch-Clamp Techniques; Peptide Fragments; Polypyrimidine Tract-Binding Protein; Prosencephalon; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-3; S100 Calcium Binding Protein G; Somatostatin; Substance P; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2004 |
Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats.
Topics: Animals; Behavior, Addictive; Cocaine; Dose-Response Relationship, Drug; Male; Motor Activity; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Substance P; Ventral Tegmental Area | 2004 |
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Indoles; Injections, Intraventricular; Male; Maze Learning; Microinjections; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P; Thiorphan; Time Factors | 2004 |
Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection.
Topics: Animals; Antiemetics; Calcitonin Gene-Related Peptide; Humans; Inflammation; Lung; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Respiratory Hypersensitivity; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Substance P | 2005 |
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.
Topics: Action Potentials; Analgesics; Animals; Antipsychotic Agents; Atropine; Electric Stimulation; Ileum; Indoles; Isoindoles; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurons; Nitroarginine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2005 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Histamine; Histidine Decarboxylase; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Histamine H1; Receptors, Neurokinin-1; Substance P; Time Factors | 2005 |
The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ilium; In Vitro Techniques; Male; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nitroarginine; Peptide Fragments; Potassium Chloride; Pyrrolidonecarboxylic Acid; Substance P; Tachykinins; Tetrodotoxin | 2006 |
Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates kainic acid-inducing degeneration of neurons in the substantia nigra of mice.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Drug Synergism; Fluoresceins; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Neurons; Organic Chemicals; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinolines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Substantia Nigra; Tetrazolium Salts; Thiazoles | 2008 |
Desflurane but not sevoflurane can increase lung resistance via tachykinin pathways.
Topics: Airway Resistance; Anesthetics, Inhalation; Animals; Desflurane; Dose-Response Relationship, Drug; Efferent Pathways; Guinea Pigs; Isoflurane; Lung Compliance; Male; Methyl Ethers; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Reflex; Sevoflurane; Substance P; Tachykinins; Vagotomy; Vagus Nerve | 2009 |
Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.
Topics: Analgesics; Animals; Behavior, Animal; Butadienes; Central Nervous System Stimulants; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Nitric Oxide; Nitriles; Nociceptors; Pain; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Spinal Cord; Stereoisomerism; Substance P | 2009 |
Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Lumbar Vertebrae; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Pain; Pain Measurement; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Spinal Nerves; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2010 |
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.
Topics: Analysis of Variance; Animals; Apomorphine; bcl-Associated Death Protein; Caspase 3; Cell Death; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidopamine; Peptide Fragments; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Rotarod Performance Test; Signal Transduction; Substance P; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity.
Topics: Amino Acid Sequence; Binding Sites; Biocatalysis; Fluorescence Resonance Energy Transfer; Glycosaminoglycans; Humans; Hydrolysis; Kallikreins; Kinetics; Kininogens; Molecular Sequence Data; Osmolar Concentration; Peptide Hydrolases; Peptides; Pyrrolidonecarboxylic Acid; Semaphorins; Serpins; Somatostatin; Substance P; Substrate Specificity; Time Factors | 2015 |
Evidence for involvement of NK₃ receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.
Topics: Animals; Anxiety; Male; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 2016 |
Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor.
Topics: Algorithms; Animals; Astrocytoma; Binding, Competitive; Cell Line, Tumor; CHO Cells; Cricetulus; Electric Impedance; Humans; Kinetics; Ligands; Nerve Tissue Proteins; Neuroglia; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Tachykinins | 2016 |