substance p has been researched along with piperidines in 451 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (1.77) | 18.7374 |
| 1990's | 205 (45.45) | 18.2507 |
| 2000's | 183 (40.58) | 29.6817 |
| 2010's | 50 (11.09) | 24.3611 |
| 2020's | 5 (1.11) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, JG; Lu, YF; Nakayama, S; Takaki, M | 1 |
| Hill, DR; Stoessl, AJ | 1 |
| Ahlman, H; Dahlström, A; Lidberg, P | 1 |
| Ahlman, H; Dahlström, A; Grönstad, K; Jaffe, BM; Nilsson, O; Oberg, K | 1 |
| Brown, DR; Chang, EB; Field, M; Wang, NS | 1 |
| Fukuhara, I; Haruma, K; Kajiyama, G; Miyoshi, A; Ohgoshi, H; Sumii, K; Tanaka, K; Tari, A; Teshima, H; Yoshihara, M | 1 |
| Minami, Y; Toda, N | 1 |
| Barnes, PJ; Ichinose, M | 1 |
| Ahlman, H; Dahlström, A; Grönstad, K; Jaffe, BM; Oberg, K; Tisell, LE; Zinner, MJ | 1 |
| Micevych, PE; Szolcsanyi, J; Yaksh, TL | 1 |
| Bruns, RF; Cox, LM; Gitter, BD; Howbert, JJ; Lobb, KL; Mason, NR; Nixon, JA; Stengel, PW; Threlkeld, PG; Waters, DC | 1 |
| Beaujouan, JC; Glowinski, J; Saffroy, M; Torrens, Y | 3 |
| Ansay, M; Delaunois, A; Garbarg, M; Gustin, P | 1 |
| Bountra, C; Bunce, K; Dale, T; Gardner, C; Jordan, C; Twissell, D; Ward, P | 1 |
| Gether, U; Schwartz, TW; Zoffmann, S | 1 |
| Bichon, D; Doutremepuich, JD; Ducoux, JP; Emonds-Alt, X; Heaulme, M; Neliat, G; Proietto, V; Santucci, V; Steinberg, R; Vilain, P | 1 |
| Gerard, NP; Gether, U; Jensen, CJ; Schwartz, TW | 1 |
| Bordey, A; Emonds-Alt, X; Feltz, P; Gauthier, T; Le Fur, G; Lefevre, IA; Oury-Donat, F; Soubrie, P; Thurneyssen, O | 1 |
| Besson, G; Drazen, JM; Israel, E; Lilly, CM; Rodger, IW | 1 |
| Kamei, C; Nakamura, S; Tasaka, K | 1 |
| Bristow, LJ; Young, L | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Mattiasson, A | 1 |
| Maggi, CA; Meini, S; Patacchini, R | 1 |
| Buéno, L; Julia, V; Morteau, O | 1 |
| Fujii, T; Hirayama, Y; Kawamura, A; Yasumitsu, R | 1 |
| Hill, RG; Longmore, J; Razzaque, Z; Shaw, D | 1 |
| Couture, R; Picard, P; Regoli, D | 1 |
| Bartke, A; Debeljuk, L | 1 |
| Desai, MC; Rizzi, JP; Vincent, LA | 1 |
| Jackson, A; Rupniak, NM | 1 |
| Bristow, DR; Dupere, JR; Zamani, MR | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L | 1 |
| Chung, FZ; Grimson, P; Guard, S; Madden, Z; Pinnock, R; Suman-Chauhan, N; Watling, K; Woodruff, G | 1 |
| Chung, FZ; Hill, DR; Madden, Z; Pinnock, RD; Suman-Chauhan, N; Webdale, L; Woodruff, GN | 1 |
| Brain, SD; Hall, JM | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Giuliani, S; Maggi, CA; Zagorodnyuk, V | 1 |
| Bonham, AC; Longhurst, JC; Pan, HL | 1 |
| Bock, MD; Clot, J; Emile, L; Fardin, V; Garret, C; Habert-Ortoli, E; Le Guern, J; Loquet, I; Mercken, L; Pradier, L | 1 |
| Cascieri, MA; Fong, TM; Hardwicke, S; Lewis, RT; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Sadowski, S; Shepheard, S | 1 |
| Brain, SD; Newbold, P | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Meini, S | 1 |
| Inoue, M; Kaya, H; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Martini, F; Puizillout, JJ; Reynaud, JC | 1 |
| Henry, JL; Radhakrishnan, V | 2 |
| Gether, U; Lowe, JA; Schwartz, TW | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 1 |
| Fukuhara, S; Mukai, H; Munekata, E | 1 |
| Akasu, T; Ishimatsu, M; Yamada, K | 1 |
| Drazen, JM; Haley, KJ; Hall, AE; Kobzik, L; Lilly, CM; Rodger, IW | 1 |
| Fong, TM; Huang, RR; Strader, CD; Vicario, PP | 1 |
| Cioncolini, F; Figini, M; Geppetti, P; Javdan, P | 1 |
| Andrews, PL; Fossa, AA; Gonsalves, SF; McLean, S; Obach, S; Seeger, T; Watson, JW | 1 |
| Killingsworth, CR; Shore, SA | 1 |
| Barthò, L; Holzer, P; Maggi, CA; Patacchini, R | 1 |
| Chan, B; Geppetti, P; Hara, M; Lindén, A; Nadel, JA; Ricciardolo, FL; Yoshihara, S | 1 |
| Beaujouan, JC; Glowinski, J; Petitet, F; Saffroy, M; Torrens, Y | 1 |
| Breliere, JC; Emonds-Alt, X; Golliot, F; Le Fur, G; Pointeau, P | 1 |
| Boucher, S; Couture, R; Gitter, BD; Howbert, JJ; Picard, P; Regoli, D | 1 |
| Bertrand, C; Desai, MC; Hoffman, JI; Husseini, WK; Nadel, JA; Petersson, G; Piedimonte, G; Snider, RM | 1 |
| Advenier, C; Emonds-Alt, X; Qian, Y | 1 |
| Brelière, JC; Emonds-Alt, X; Gether, U; Lowe, JA; Nakanishi, S; Schwartz, TW; Snider, RM; Yokota, Y | 1 |
| Bertrand, C; Desai, MC; Geppetti, P; Nadel, JA; Piedimonte, G; Snider, RM | 1 |
| Desai, MC; Hoffman, JI; Husseini, WK; Nadel, JA; Piedimonte, G; Snider, RM | 1 |
| Bachy, A; Emerit, MB; Giudice, A; Gozlan, H; Hamon, M; Héaulme, M; Lefevre, IA; Manara, L; Michaud, JC; Souilhac, J | 1 |
| Bertrand, C; Bunnett, NW; Debas, HT; Geppetti, P; Huber, O; Nadel, JA; Pellegrini, CA | 1 |
| DeSautel, MG; Maher, JW; Sandler, AD; Schlegel, JF | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R | 1 |
| Bartho, L; Giuliani, S; Maggi, CA; Santicioli, P | 1 |
| Boucher, S; Couture, R; Picard, P; Regoli, D | 1 |
| Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Champion, E; Foulon, DM; Jones, TR; Masson, P; Rodger, IW | 1 |
| Bryce, DK; Desai, MC; Ganong, A; Longo, KP; McLean, S; Reynolds, LS; Robinson, G; Rosen, T; Seymour, PA; Snider, RM | 1 |
| Bryce, D; Chalabi, PM; Desai, MC; Guarino, KJ; Heym, J; McLean, S; Pratt, K; Rosen, T; Seeger, TF; Windels, JH | 1 |
| McKee, KT; Metters, KM; Millar, L; Rodger, IW | 1 |
| Everaert, E; Germonpré, PR; Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Beattie, DT; Brain, SD; Connor, HE; Escott, KJ | 1 |
| Doerfler, DL; Sailstad, DM; Selgrade, M; Veronesi, B | 1 |
| Maggi, CA; Zagorodnyuk, V | 1 |
| Calixto, JB; Campos, AH; Cechinel Filho, V; Dias, MA; Yunes, RA | 1 |
| Ikeda, K; Kubota, H; Miyata, K; Orita, A; Tomioka, K; Yamada, T | 1 |
| Burkholder, TP; Knippenberg, RW; Kudlacz, EM; Logan, DE; Poirot, M; Shatzer, SA; van Giersbergen, PL | 1 |
| Bryce, DK; Crawford, RT; DePasquale, M; Fossa, A; Ganong, A; Heym, J; McLean, S; Morrone, J; Nagahisa, A; Reynolds, LS; Rosen, T; Schmidt, AW; Seymour, PA; Tsuchiya, M; Watson, J; Zorn, S | 1 |
| Farina, C; Foley, JJ; Giardina, GA; Grugni, M; Hay, DW; Medhurst, AD; Raveglia, LF; Rigolio, R; Sarau, HM; Schmidt, DB; Vassallo, M; Vecchietti, V | 1 |
| Gascón, P; Rameshwar, P | 1 |
| Chan, CC; Rodger, IW; Savoie, C; Tousignant, C | 1 |
| Sammarco, J; Washabau, RJ | 1 |
| Neugebauer, V; Rumenapp, P; Schaible, HG | 1 |
| Beattie, DT; Beresford, IJ; Birch, PJ; Bowers, J; Connor, HE; Hagan, RM; Hawcock, AB; Marshall, FH; Ward, P | 1 |
| Antunes, E; Brain, SD; Costa, SK; de Nucci, G; Palframan, RT; Wilsoncroft, P | 1 |
| Jafri, MS; Weinreich, D | 2 |
| Chapman, RW; Danko, G; del Prado, M; Hey, JA | 1 |
| De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Tramontana, M | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH | 1 |
| Gehlert, DR; Gitter, BD; Hipskind, PA; Howbert, JJ; Schober, DA | 1 |
| Cascieri, M; Hargreaves, RJ; Hill, RG; Marmont, N; Rycroft, W; Tattersall, FD | 1 |
| KAMEI, CH | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 2 |
| Bernat, A; Herbert, JM | 1 |
| Marchionni, D; Nisato, D; Roccon, A | 1 |
| Henry, JL; Hui-Chan, CW; Yashpal, K | 1 |
| Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Ansay, M; Delaunois, A; Gustin, P; Segura, P; Vargas, M | 1 |
| Barnouin, MC; Emonds-Alt, X; Hayar, A; Jung, M; Le Fur, G; Michaud, JC; Mons, G; Soubrié, P; Souilhac, J; Steinberg, R | 1 |
| Lundberg, JM; Rinder, J | 1 |
| Cavero, I; Floch, A; Thiry, C | 1 |
| Bonnet, J; Canet, E; Dacquet, C; Fauchère, JL; Kucharczyk, N; Lonchampt, M; Regoli, D; Robineau, P | 1 |
| Brain, SD; Siney, L | 1 |
| Calixto, JB; De Lima, TC; Rae, GA; Ribeiro, SJ; Santos, AR; Teixeira, RM | 1 |
| Boyce, S; Carlson, E; Hill, RG; Rupniak, NMJ; Webb, JK | 1 |
| Carlton, SM; Coggeshall, RE; Zhou, S | 1 |
| Arakawa, M; Goto, F; Katori, M; Majima, M; Nagai, K | 1 |
| Caldwell, RW; Chiao, H | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D | 1 |
| Budai, D; Larson, AA | 1 |
| Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Nguyen-Le, XK; Regoli, D | 1 |
| Blazy, C; Brelire, JC; Casellas, P; Derocq, JM; Emonds-Alt, X; Le Fur, G; Ségui, M | 1 |
| Boyer, V; Harf, A; Jarreau, PH; Macquin-Mavier, I | 1 |
| Boucher, S; Couture, R; Gehlert, DR; Helton, DR; Hipskind, PA; Iyengar, S; Kallman, MJ; Li, DL; Lobb, KL; Nixon, JA; Schober, D; Simmons, RM | 1 |
| Costa, C; Cozzolino, A; Esposito, C; Falciani, M; Filippelli, A; Porta, R; Rossi, F | 1 |
| Kingsley, RE; Marfurt, CF | 1 |
| Boucher, RC; Costa, DL; Lehmann, JR; McCarty, D; Pickles, RJ; Piedimonte, G | 1 |
| Alonso, R; Carayon, P; Fournier, M; Le Fur, G; Petitpretre, G; Soubrié, P | 1 |
| Lucot, JB; McLean, S; Obach, RS; Watson, JW | 1 |
| Hay, DW; Medhurst, AD; Parsons, AA; Roberts, JC | 1 |
| Bertrand, C; Emanueli, C; Figini, M; Geppetti, P; Regoli, D; Sicuteri, R | 1 |
| Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ | 1 |
| Farley, DM; Kopp, UC; Smith, LA | 1 |
| Burkholder, TP; Kehne, JH; Knippenberg, RW; Kudlacz, EM; McCloskey, TC; Shatzer, SA | 1 |
| O'Grady, SM; Vetter, AE | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Hardwick, JC; Mawe, GM; Parsons, RL | 1 |
| Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Parsons, AA | 1 |
| Fisher, L; Pennefather, JN | 1 |
| MacNaughton, W; Moore, B; Vanner, S | 1 |
| Barbot, L; Cellier, E; Couture, R; Regoli, D | 1 |
| Chahl, LA; Yip, J | 2 |
| Advenier, C; Canet, E; Félétou, M; Girard, V | 1 |
| Bian, K; Bukoski, RD; Mupanomunda, M; Wang, Y | 1 |
| Holst, JJ; Rasmussen, TN; Schmidt, PT | 1 |
| Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL | 1 |
| Henry, JL; Iyengar, S; Radhakrishnan, V | 1 |
| Jino, H; Kanda, M; Kurahashi, K; Murase, K; Nakamura, S; Shirahase, H; Usui, H | 1 |
| Hosoki, R; Onishi, Y; Otsuka, M; Yanagisawa, M; Yoshioka, K | 1 |
| Anthes, J; Billah, M; Brown, JE; Cheewatrakoolpong, B; Egan, RW; Greenfeder, S; Murgolo, NJ | 1 |
| Evans, RH; Ofner, S; Olpe, HR; Pozza, MF; Schoeffel, C | 1 |
| Criscuoli, M; Lippi, A; Maggi, CA; Santicioli, P | 1 |
| Blackshaw, LA; Lynn, PA; Smid, SD; Templeman, R | 1 |
| Bunnett, NW; Emanueli, C; Figini, M; Geppetti, P; Grady, EF; Madeddu, P; Parisi, D; Regoli, D | 1 |
| Blumenthal, JA; Carey, HV; Onorato, JJ | 1 |
| Belmonte, KE; Costello, RW; Fryer, AD; Jacoby, DB | 1 |
| Bannon, MJ; Hahn, MK | 1 |
| Lieberman, DN; Mody, I | 1 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P | 1 |
| Corboz, MR; Hey, JA; Ramos, SI; Rivelli, MA; Rizzo, CA | 1 |
| Goadsby, PJ; Hoskin, KL; Knight, YE | 1 |
| Chapman, RW; Egan, RW; Kreutner, W; Schilling, A; Selig, W; Sherwood, JE; Young, S | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Bourque, MJ; Robitaille, R | 1 |
| Brené, S; Lindefors, N; Zachrisson, O | 1 |
| Bell, MI; Lee, K; Richardson, PJ | 1 |
| Kouznetsova, M; Nistri, A | 2 |
| Burcher, E; Nail, BS; Yuan, L | 1 |
| Colquhoun, EQ; Eldershaw, TP; Geraghty, DP; Griffiths, CD | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Moore, KA; Taylor, GE; Weinreich, D | 1 |
| Bindslev, N; Hansen, MB; Schmidt, P; Skadhauge, E; Thorbøll, JE | 1 |
| Bougault, I; Le Fur, G; Marco, N; Mons, G; Soubrié, P; Steinberg, R; Thirion, A | 1 |
| Brain, SD; Towler, PK | 1 |
| Fujiwara, H; Hirata, K; Kanazawa, H; Yoshikawa, J | 1 |
| Guo, JZ; Otsuka, M; Yoshioka, K | 1 |
| Kanda, M; Kurahashi, K; Murase, K; Nakamura, S; Shirahase, H | 1 |
| Furness, JB; Jenkinson, KM; Southwell, BR | 1 |
| Angelucci, D; Büchler, MW; Di Mola, FF; Di Sebastiano, P; Friess, H; Grossi, L; Innocenti, P; Marzio, L | 1 |
| Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G | 1 |
| Chen, P; Hua, XY; Marsala, M; Yaksh, TL | 1 |
| Bakhle, YS; Bell, C; Brogan, JD | 1 |
| Brain, SD; Brown, B; Hoult, JR; Pintér, E | 1 |
| Linden, DR; Seybold, VS | 1 |
| Ariumi, H; Hashiguchi, T; Hori, N; Kamiya, H; Migita, K; Saeki, M; Saito, R; Sakai, M; Suehiro, Y; Takano, Y | 1 |
| Buéno, L; Gebhart, GF; Julia, V; Su, X | 1 |
| Furness, JB; Mann, PT; Southwell, BR | 1 |
| Binder, W; Scott, C; Walker, JS | 1 |
| Häbler, HJ; Jänig, W; Stegmann, JU; Timmermann, L | 1 |
| Perfumi, MC; Piccoli, M; Romagnoli, S; Santoni, G; Spreghini, E | 1 |
| Barbot, L; Cellier, E; Couture, R; Iyengar, S | 1 |
| Chabot, J; Coderre, TJ; Henry, JL; Pitcher, GM; Yashpal, K | 1 |
| Kohno, S; Nabe, T; Ogawa, K; Yamamura, H | 1 |
| Inoue, M; Renbäck, K; Ueda, H | 1 |
| Inoue, M; Katsuyama, S; Kisara, K; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K; Ueda, H | 1 |
| Barbara, G; Bunnett, NW; Collins, SM; Figini, M; Geppetti, P; Gerard, C; Gerard, N; Grady, EF; Qiu, B; Sturiale, S | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Abbadie, C; Basbaum, AI; Mantyh, PW; Marchand, S; Trafton, JA | 1 |
| Bönisch, H; Brüss, M; Göthert, M; Molderings, GJ | 1 |
| Katsuyama, S; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K | 1 |
| Kasparov, S; Paton, JF | 1 |
| Haefeli, WE; Linder, L; Romerio, SC | 1 |
| Gerard, NP; Nguyen, N; Pasricha, PJ; Saban, MR; Saban, R | 1 |
| Khawaja, AM; Liu, Y; Rogers, DF | 1 |
| Gascón, P; Hameed, M; Joshi, DD; Maloof, PB; Mosenthal, A; Qian, J; Rameshwar, P; Singh, D | 1 |
| Moore, KA; Undem, BJ; Weinreich, D | 1 |
| Bassirat, M; Khalil, Z | 1 |
| Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P | 1 |
| Barthó, L; Corinaldesi, R; De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Sternini, C; Tramontana, M | 1 |
| Calixto, JB; De Lima, TC; Ribeiro, SJ; Teixeira, RM | 1 |
| Bialecki, R; Caccese, R; Graham, A | 1 |
| Carter, JD; Devlin, RB; Oortgiesen, M; Simon, SA; Veronesi, B | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Barbot, L; Couture, R; Toma, N | 1 |
| Yonehara, N; Yoshimura, M | 2 |
| Kanda, M; Kurahashi, K; Nakamura, S; Shirahase, H | 1 |
| Geraghty, DP; Mazzone, SB | 1 |
| Barthó, L; Benkó, R; Lázár, Z; Lénárd, L; Maggi, CA; Penke, B; Szolcsányi, J; Tóth, G | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Lagente, V; Naline, E | 1 |
| Berggreen, E; Heyeraas, KJ | 1 |
| Hitzel, L; Keown, LE; Ladduwahetty, T; Lewis, RT; MacLeod, AM; Merchant, KJ; Stevenson, GI; Verrier, H | 1 |
| Carlson, EC; de Felipe, C; Harrison, T; Hunt, S; Oates, B; Owen, S; Rupniak, NM; Seward, E; Wheeldon, A | 1 |
| Crane, LH; Hamlin, GP; Nimmo, AJ; Williams, MJ | 1 |
| Ariumi, H; Hyakusoku, M; Kamiya, H; Nago, S; Saito, R; Takano, Y | 1 |
| Kamiki, T; Kohno, S; Nabe, T; Tanpo, T; Yasui, K | 1 |
| Holzer, P; Shahbazian, A | 1 |
| Berggreen, P; Ersbøll, AK; Grøndahl, ML; Hansen, MB; Maltbaek, JS; Skadhauge, E; Thorbøll, JE | 1 |
| Farkas, B; Helyes, ZS; Németh, J; Oroszi, G; Pintér, E; Szolcsányi, J; Thán, M | 1 |
| Oh, EJ; Thompson, LP; Weinreich, D | 1 |
| Bakhle, YS; Beddy, P; Bell, C; Campbell, VA; Foley, A | 1 |
| Belmonte, KE; Costello, RW; Evans, CM; Fryer, AD; Gleich, GJ; Jacoby, DB | 1 |
| Lam, FF; Yip, AL | 1 |
| Compernolle, F; De Wit, T; Hoornaert, GJ; Van Emelen, K | 1 |
| Black, LS; D'Angelo, R; Dalby, PL; Gesztesi, Z; MacLean, D; Scuderi, PE; Wender, RH; White, PF; Wright, W | 1 |
| Kim, D; Moore, BA; Vanner, S | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G | 1 |
| Broccardo, M; Improta, G | 1 |
| Amann, R; Egger, T; Schuligoi, R | 1 |
| Brugger, F; Gentsch, C; Hauser, K; Ofner, S; Schilling, W; Vassout, A; Veenstra, S | 1 |
| Cruwys, SC; Hood, VC; Kidd, BL; Urban, L | 1 |
| Jurzak, M; Langlois, X; Leysen, JE; te Riele , P; Wintmolders, C | 1 |
| Amadesi, S; Ansel, JC; Armstrong, CA; Bonaccorsi, P; Bunnett, NW; Geppetti, P; Gerard, NP; Grady, EF; Klein, R; Lu, B; Luger, TA; Olerud, JE; Scholzen, TE; Steinhoff, M | 1 |
| Hu, C; Jiang, X; King, KA; Piedimonte, G; Rodriguez, MM; Romaguera, R | 1 |
| Krysiak, PS; Preiksaitis, HG | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Furness, JB; Southwell, BR | 1 |
| Abbadie, C; Basbaum, AI; Trafton, JA | 1 |
| Chen, J; Zheng, JH | 1 |
| Gibbins, IL; Jobling, P; Messenger, JP | 1 |
| Dey, RD; Fedan, JS; Frazer, DG; Maize, DF; Satterfield, BE; Wu, ZX | 1 |
| Abbott, BM; Aharony, D; Albert, JS; Barthlow, HG; Bernstein, PR; Bialecki, RA; Brown, F; Caccese, R; Ghanekar, S; Lengel, D; McCarthy, M; Ohnmacht, C; Rumsey, WL; Russell, K; Shenvi, A; Undem, B; Wenrich, B | 1 |
| Hughes, J; Maneuf, YP; McKnight, AT | 1 |
| Aggio, A; Carnicelli, V; Ciccocioppo, R; Onori, L; Severi, C; Taddei, G; Tonini, M | 1 |
| Manning, BP; Mawe, GM | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; O'Donoghue, DP; Selve, N | 1 |
| Hayashi, K; Ishii, A; Kaise, T; Karasawa, A; Ohmori, K; Sano, J; Sato, H | 1 |
| Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT | 1 |
| Carpenter, TC; Stenmark, KR | 1 |
| Jurzak, M; Langlois, X; Leysen, JE; te Riele, P; Wintmolders, C | 1 |
| Andrews, PL; Endo, T; Hamaue, N; Hirafuji, M; Minami, M; Nagahisa, A; Nemoto, M; Ogawa, T; Yokota, H; Yoshioka, M | 1 |
| Advenier, C; D'Agostino, B; Falciani, M; Filippelli, A; Gallelli, L; Marrocco, G; Piegari, E; Rossi, F | 1 |
| Couture, R; Lessard, A | 1 |
| Allouard, N; Bert, L; Bougault, I; Le-Fur, G; Rodier, D; Soubrié, P; Steinberg, R | 1 |
| Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K | 1 |
| Lever, IJ; Malcangio, M | 1 |
| Chen, CF; Chu, SJ; Lai, YL; Ma, MC | 1 |
| Bradesi, S; Bueno, L; Eutamene, H; Fioramonti, J | 1 |
| Hillier, MC; Reider, PJ | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Gueudet, C; Le Fur, G; Maffrand, JP; Michaud, JC; Naline, E; Oury-Donat, F; Pascal, M; Poncelet, M; Proietto, V; Soubrié, P; Steinberg, R; Vilain, P | 1 |
| Bredesen, DE; Castro-Obregón, S; Chen, SF; Del Rio, G; Frankowski, H; Nicholls, DG; Rao, RV; Stoka, V; Swanson, RA; Vesce, S | 1 |
| Anukwu, LU; Canning, BJ; Kajekar, R; Myers, AC; Reynolds, SM | 1 |
| Ashton, D; Fransen, JF; Hens, KA; Heylen, L; Hillen, LC; Janssens, F; Jurzak, MR; Leysen, JE; Mahieu, M; Megens, AA; Vermeire, JC; Vermote, PC | 1 |
| Bigg, CS; Coulson, FR; O'Donnell, SR | 1 |
| Angstwurm, K; Bille, MB; Dirnagl, U; Hoffmann, O; Keilwerth, N; Reuter, U; Schumann, RR; Weber, JR | 1 |
| Akhtar, R; Brain, SD; Gerard, NP; Grant, AD | 1 |
| Bakalkin, G; Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, C; Sakurada, T; Tadano, T; Tan-No, K; Terenius, L | 1 |
| Boscan, P; Kasparov, S; Paton, JF | 1 |
| Angulo, JA; Cadet, JL; Yu, J | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Furuta, S; Mobarakeh, JI; Onodera, K; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, H; Watanabe, T; Yanai, K | 1 |
| Bakhle, YS; Bell, C; Brady, F | 1 |
| Helyes, Z; Jakab, B; Németh, J; Pintér, E; Szolcsányi, J; Thán, M | 1 |
| De Swert, KO; Joos, GF; Leclere, PG; Lefebvre, RA; Pauwels, RA; Tournoy, KG | 1 |
| Kakuta, S; Oda, S; Tanihata, S; Uchiyama, T | 1 |
| Chien, CT; Hsu, SM; Lai, MK; Lin, TB; Yu, HJ | 1 |
| Adkins, B; Auais, A; Napchan, G; Piedimonte, G | 1 |
| Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T | 1 |
| Aggio, A; Ciccocioppo, R; Loreto, MF; Onori, L; Taddei, G; Tonini, M; Vicini, R | 1 |
| Dey, RD; Satterfield, BE; Wu, ZX | 1 |
| Choi, SS; Han, EJ; Han, KJ; Kim, DH; Lee, HK; Lee, JK; Suh, HW | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Boscan, P; Paton, JF; Pickering, AE | 1 |
| Ogier, R; Raggenbass, M | 1 |
| Cvetkovic, V; Fellmann, D; Griffond, B; Poncet, F; Risold, PY | 1 |
| El-Mahmoudy, A; Khalifa, M; Matsuyama, H; Shimizu, Y; Takewaki, T | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A | 1 |
| Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Hamada, K; Hanioka, N; Imazumi, K; Maeda, Y; Manda, T; Matsuo, M; Mutoh, S; Yamamoto, T | 1 |
| Bonham, AC; Bric, JM; Chen, CY; Evans, SJ; Joad, JP; Munch, PA; Pinkerton, KE | 1 |
| Clark, JD; Davies, MF; Guo, TZ; Jacobs, CR; Kingery, WS; Offley, SC | 1 |
| Advenier, C; Bardou, M; Cui, YY; D'Agostino, B; Faisy, C; Naline, E; Rouget, C | 1 |
| Amantini, C; Lucciarini, R; Perfumi, M; Piccoli, M; Pompei, P; Santoni, G | 1 |
| Jang, JH; Leem, JW; Nam, TS; Paik, KS | 1 |
| de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM | 1 |
| Boyd, EA; Guo, TZ; Jacobs, CR; Kingery, WS; Offley, SC | 1 |
| Bornstein, JC; Johnson, PJ | 1 |
| Goromaru, T; Hirakawa, T; Ishida, M; Itoh, Y; Nakano, H; Oishi, R; Sendo, T | 1 |
| Castro, E; Coveñas, R; Muñoz, M; Pérez, A; Rosso, M | 1 |
| De Lima, TC; Duarte, FS; Testolin, R | 1 |
| Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Yamashita, M | 1 |
| Baroni, S; Betti, L; Cassano, GB; Giannaccini, G; Giusti, L; Lucacchini, A; Marazziti, D | 1 |
| Guo, ZQ; Huang, PQ; Liu, LX; Ruan, YP | 1 |
| Bellucci, F; Candenas, ML; Catalani, C; Catalioto, RM; Faiella, A; Giolitti, A; Giuliani, S; Maggi, CA; Meini, S; Pinto, FM; Quartara, L; Rotondaro, L | 1 |
| Charette, AB; Grenon, M; Lemire, A; Pourashraf, M | 1 |
| Bienenstock, J; Furuno, T; Ma, D; Nakanishi, M; van der Kleij, HP | 1 |
| Akici, A; Ercan, F; Erin, N; Ersoy, Y; Oktay, S | 1 |
| Fiebich, BL; Heinen, M; Herpfer, I; Kupferschmid, S; Langosch, JM; Lieb, K; Walden, J | 1 |
| Boscan, P; Dutschmann, M; Herbert, H; Paton, JF | 1 |
| Comet, MA; Hamon, M; Laguzzi, R; Sévoz-Couche, C | 1 |
| Inoue, A; Kawamoto, M; Nakata, Y; Oshita, K; Tang, HB; Yuge, O | 1 |
| Bianchi, C; Della Corte, L; Fantin, M; Manzalini, M; Marti, M; Morari, M | 1 |
| Couture, R; Deschamps, K | 1 |
| Altamura, M; Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Guidi, A; Maggi, CA; Meini, S; Pasqui, F; Rotondaro, L; Zappitelli, S | 1 |
| De Man, JG; De Schepper, HU; De Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC | 1 |
| Coveñas, R; Muñoz, M; Pérez, A; Piruat, JI; Rosso, M; Rosso, R; Zamarriego, C | 1 |
| Coveñas, R; Montero, I; Muñoz, M; Pérez, A; Rosso, M; Rosso, R; Soult, JA; Zamarriego, C | 1 |
| Bertrand, PP; Bornstein, JC; Monro, RL | 1 |
| Easton, AS; Fraser, PA; Hu, DE | 1 |
| Abe, T; Arisaka, O; Morimoto, H; Ohori, M; Yamada, Y; Yoshihara, S | 1 |
| Akici, A; Ercan, F; Erin, N; Ersoy, Y; Hürdag, C | 1 |
| Brain, SD; Costa, SK; Muscará, MN; Poston, RN; Yshii, LM | 1 |
| Huizinga, JD; Nieuwmeyer, F; Ye, J | 1 |
| Abdel-Aziz, H; Ploch, M; Verspohl, EJ; Windeck, T | 1 |
| Bianchetti, A; Croci, T; Di Marzo, V; Di Palo, S; Ferla, G; Guagnini, F; Matias, I; Mukenge, S; Valenti, M | 1 |
| Benetti, E; Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Rosa, AC | 1 |
| Brouillette, J; Cloutier, F; Couture, R; Deschamps, K; Neugebauer, W; Ongali, B | 1 |
| Andreetta, F; Carletti, R; Corsi, M; Griffante, C | 1 |
| Peña, F; Ramirez, JM; Tryba, AK | 1 |
| Burns, D; Eskola, O; Hargreaves, R; Hietala, J; Kajander, J; Nyman, MJ; Sanabria, S; Solin, O; Vahlberg, T | 1 |
| Akada, Y; Amano, K; Fukudome, Y; Itoh, M; Ogawa, S; Yamamoto, I; Yamasaki, F | 1 |
| Cicha, MZ; Kopp, UC; Smith, LA | 1 |
| Fiebich, BL; Hamke, M; Herpfer, I; Lieb, K; Wandelt, C | 1 |
| Hauer-Jensen, M; Kulkarni, A; Qiu, X; Wang, J | 1 |
| Fong, AY; Potts, JT | 2 |
| Andoh, T; Kuraishi, Y | 1 |
| Brain, SD; Costa, SK; Gilmore, D; Hyslop, S; Starr, A | 1 |
| Fabry, Z; Johnson, MJ; Karman, J; Lee, J; Ling, C; Reinke, EK; Sandor, M; Weinstock, JV | 1 |
| Elliott, JC; Lysle, DT; Wagner, AF | 1 |
| Budai, D; Khasabov, SG; Mantyh, PW; Simone, DA | 1 |
| Ando, K; Haneda, E; Higuchi, M; Ikehira, H; Inaji, M; Maeda, J; Nagai, Y; Nakao, R; Narazaki, M; Obayashi, S; Okauchi, T; Suhara, T; Suzuki, H; Suzuki, K; Zhang, MR | 1 |
| Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Appleyard, CB; Morales, M; Santiago, C | 1 |
| Coveñas, R; González-Moles, MA; Montero, I; Muñoz, M; Robles, MJ; Rosso, M | 1 |
| Inoue, T; Ishikawa, T; Kamei, C; Ohtsu, H; Rahman, MA; Yatsuzuka, R | 1 |
| Chen, J; Fu, CY; Han, M; Long, Y; Tian, XZ; Wang, R | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Long, Y; Wang, R | 1 |
| Aguilar, FJ; Esteban, F; González-Moles, MA; Muñoz, M; Redondo, M; Rosso, M | 1 |
| Adolfsson, R; Ahlstedt, I; de Verdier, J; Drmota, T; Engberg, S; Johansson, A; Jussila, R; Kristensson, E; Leffler, A; Lindström, E; Novén, A; Påhlman, I; Sigfridsson, K; Sundqvist, M; von Mentzer, B | 1 |
| Bilbao, A; Fernandez-Espejo, E; Ferrer, B; Gorriti, MA; Martín, AB; Moratalla, R; Navarro, M; Rodriguez de Fonseca, F | 1 |
| Coste, J; Dallel, R; Luccarini, P; Miraucourt, LS; Voisin, DL | 1 |
| Asai, H; Ishii, T; Kiuchi, S; Nagasaki, M; Okamoto, M; Saito, A; Taniguchi, H; Watanabe, Y | 1 |
| Chang, LC; Chen, WC; Li, PC; Lin, SC | 1 |
| Alfaro, MF; Hyde, DM; Oslund, KL; Putney, LF; Schelegle, ES; Tyler, NK; Walby, WF | 1 |
| Barrett, E; Xu, F; Xu, J | 1 |
| Abad, J; Darmani, NA; Ramirez, J; Ray, AP; Thrush, GR; Wang, Y | 1 |
| Kamei, C; Kuyama, S; Ogawa, M; Yokota, E | 1 |
| Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T | 1 |
| Antunes, E; Camargo, EA; de Nucci, G; Ferreira, T; Landucci, EC; Ribela, MT | 1 |
| Brocco, M; de Nanteuil, G; deJong, TR; Dekeyne, A; Girardon, S; Mannoury la Cour, C; Millan, MJ; Olivier, B; Touzard, M; Veiga, S | 1 |
| Chicchi, GG; Ebner, K; Ferraguti, F; Schmidhammer, H; Singewald, GM; Singewald, N; Spetea, M; Sreepathi, HK; Thurner, CC; Tsao, KL | 1 |
| Darmani, NA; Griggs, L; Ray, AP | 1 |
| Coveñas, R; Muñoz, M; Robles-Frías, MJ; Rosso, M; Salinas-Martín, MV | 1 |
| Dolber, PC; Douglas, KL; Eldaif, BM; Fraser, MO; Jin, H; Nassar, R; Zhang, X | 1 |
| Camargo, Lde L; Costa, SK; Denadai-Souza, A; Keeble, JE; Muscará, MN; Ribela, MT | 1 |
| Ebner, K; Muigg, P; Singewald, G; Singewald, N | 1 |
| Boudaka, A; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J | 1 |
| De Ponti, F; Ursino, MG; Vasina, V | 1 |
| Cicha, MZ; Grisk, O; Hökfelt, T; Kopp, UC; Mähler, N; Schlüter, T; Smith, LA; Steinbach, A | 1 |
| El Manira, A; Grillner, S; Hill, RH; Thörn Pérez, C | 1 |
| Katsuyama, S; Kohno, K; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Shiohira, H; Tsuzuki, M | 1 |
| Grider, JR; Kuemmerle, JF; Li, Y; Mahavadi, S; Martin, BR; Murthy, KS; Qiao, LY | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Qiao, Y; Sahbaie, P; Shi, X; Yeomans, DC | 1 |
| Clark, JD; Guo, TZ; Kingery, WS; Li, WW; Liang, D; Shi, X; Wei, T | 1 |
| Wang, DH; Xie, C | 1 |
| Hamity, MV; Hammond, DL; White, SR | 1 |
| Asano, K; Ikeda, T; Kureyama, N; Yamamoto, K; Yamatodani, A | 1 |
| Chen, W; Lao, L; Marvizón, JC; Zhang, G | 1 |
| Alysandratos, KD; Angelidou, A; Asadi, S; Conti, P; Kalogeromitros, D; Kempuraj, D; Leeman, S; Peterson, E; Stavrianeas, N; Tagen, M; Theoharides, TC; Vasiadi, M; Zhang, B | 1 |
| Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S | 1 |
| Mizoguchi, H; Sakurada, S; Watanabe, C; Yonezawa, A | 1 |
| Câmara, PR; Casatti, CA; Cenac, N; Costa, SK; Denadai-Souza, A; Muscará, MN; Vergnolle, N; Yshii, LM | 1 |
| Corboz, MR; Eckel, SP; Rivelli, MA | 1 |
| Coveñas, R; González-Ortega, A; Muñoz, M | 1 |
| Dong, R; Lu, BS; Zhang, M | 1 |
| Bani, MS; Bettica, PU; Charney, DS; Feder, A; Kinkead, B; Luckenbaugh, DA; Mathew, SJ; Murrough, JW; Parides, MK; Ratti, EM; Trist, DG; Vythilingam, M; Zarate, CA | 1 |
| Kruse, CG; McCreary, AC; Wadman, WJ; Werkman, TR | 1 |
| Bonham, AC; Joad, JP; Pinkerton, KE; Sekizawa, S | 1 |
| Almendro, V; Ametller, E; Casas, I; Fernández-Nogueira, P; García-Recio, S; Gascón, P; Mayordomo, C; Pastor-Arroyo, EM; Vinyals, L | 1 |
| Alkam, T; Amos, B; Chebolu, S; Darmani, NA | 1 |
| Coveñas, R; Rodriguez, FD | 1 |
| Fish, EW; Heilig, M; Krouse, MC; Malanga, CJ; Robinson, JE; Thorsell, A | 1 |
| Åhs, F; Appel, L; Danfors, T; Fredrikson, M; Furmark, T; Kumlien, E; Linnman, C | 1 |
| Henry, PJ; Mann, TS; Taylor, SJ | 1 |
| Aricò, G; Parenti, C; Ronsisvalle, G; Scoto, GM | 1 |
| Clark, JD; Guo, TZ; Kingery, WS; Li, WW; Liang, DY; Sun, Y | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C | 1 |
| Thornton, E; Vink, R | 1 |
| Culman, J; Hunt, SP; Tauer, U; Zhao, Y | 1 |
| Hayashi, H; Oh-ishi, T; Onaga, T; Shimoda, T | 1 |
| Wang, DH; Wang, Y | 1 |
| Carranza, A; Coveñas, R; González-Ortega, A; Muñoz, M; Robles-Frias, MJ; Rosso, M; Salinas-Martín, MV | 1 |
| Boehm, U; de Croft, S; Herbison, AE | 1 |
| Clark, JD; Kingery, WS; Shi, X; Wang, L | 1 |
| Akiyama, T; Carstens, E; Carstens, MI; Takamori, K; Tominaga, M | 1 |
| Chen, R; Ding, F; Lin, D; Liu, K; Liu, R; Liu, Y; Ran, H; Sun, Y; Wang, J; Wang, Q; Wang, Y | 1 |
| Fisher, A; Ratti, E; Trower, MK; Upton, N | 1 |
| Ballard, TM; Bissantz, C; Bohnert, C; Knoflach, F; Knust, H; Malherbe, P; Marcuz, A; Ratni, H; Spooren, W; Weber, M | 1 |
| Almendro, V; Carranza, A; Coveñas, R; Garcia-Recio, S; González-Ortega, A; Muñoz, M; Salinas-Martín, MV | 1 |
| Endo, T; Komatsu, Y; Yanagawa, Y | 1 |
| Doyle, JR; Fortin, JP; Harwood, BN; Kopin, AS; Krishnaji, ST; Krishnamurthy, VM; Kumar, K; Lin, WE | 1 |
| Dong, J; Feng, F; Hong, L; Xu, G; Yang, J; Zhang, H | 1 |
| Ding, D; Hu, JL; Liu, XP; Ren, H; Wang, JG; Yang, WL; Yu, J; Zhang, L | 1 |
| Decorps, J; Fromy, B; Gohin, S; Sigaudo-Roussel, D | 1 |
| Kanyshkova, T; Lange, MD; Pape, HC; Romo-Parra, H; Sartori, SB; Singewald, N; Sosulina, L; Strippel, C; Walter, AL | 1 |
| Åhs, F; Appel, L; Fernandez, M; Frans, Ö; Fredrikson, M; Frick, A; Furmark, T; Jonasson, M; Lubberink, M; Palmquist, ÅM; Pissiota, A; von Knorring, L; Wallenquist, U | 1 |
| Clark, JD; Guo, TZ; Kingery, WS; Li, WW; Wei, T | 1 |
| De Lima, TC; Duarte, FS; Duzzioni, M; Leme, LR; Smith, Sde P | 1 |
| Antonioli, L; Bernardini, N; Blandini, F; Blandizzi, C; Cerri, S; Colucci, R; Cseri, K; Fornai, M; Haskó, G; Ippolito, C; Levandis, G; Pellegrini, C; Segnani, C; Tirotta, E | 1 |
| Chang, C; Ling, J; Lv, B; Ping, F; Qian, J; Shang, J; Song, H; Wang, L; Wang, Y; Zhou, J | 1 |
| Almeida, MPA; Bakhle, YS; Frade, TIC; Francischi, JN; Queiroz, BFG | 1 |
| Alevizos, M; Conti, P; Karagkouni, A; Leeman, SE; Norwitz, E; Taracanova, A; Theoharides, TC; Weng, Z | 1 |
| Bing, G; Byun, JK; Dang, DK; Hong, JS; Jang, CG; Jeong, JH; Kim, DJ; Kim, HC; Ko, SK; Nah, SY; Shin, EJ; Tran, HQ | 1 |
| He, F; Li, Q; Luo, C; Tao, L; Wu, X; Xu, X; Yang, Y; Zhang, Y; Zhang, Z | 1 |
| Bonci, A; Demarest, TG; Francis, TC; Shen, H; Yano, H | 1 |
| Andruszkow, H; Andruszkow, J; Greven, J; Hildebrand, F; Hofman, M; Kobbe, P; Kolejewska, A; Lammers, T; Möckel, D; Poeze, M; Rabenschlag, F; Teuben, MPJ | 1 |
| Ayer, S; Bliss, SA; Eljarrah, A; Gergues, M; Gnanavel, N; Greco, SJ; Nagula, V; Qian, J; Rameshwar, P; Sinha, G; Wu, Q; Yehia, G | 1 |
| Hatano, M; Kimura, K; Nishida, T; Uchi, SH; Yamada, N; Yanai, R | 1 |
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| Feng, N; Han, G; Hou, X; Li, Y; Liu, W; Wu, H; Xing, B; Zhang, J | 1 |
3 review(s) available for substance p and piperidines
| Article | Year |
|---|---|
Tachykinin non-peptide antagonists: binding domain and molecular mode of action.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Biphenyl Compounds; GTP-Binding Proteins; Humans; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Receptors, Tachykinin; Recombinant Fusion Proteins; Substance P; Tachykinins | 1995 |
Stereoselective synthesis from a process research perspective.
Topics: Animals; Carbapenems; Combinatorial Chemistry Techniques; Endothelin Receptor Antagonists; Humans; Indans; Muscarinic Antagonists; Pharmaceutical Preparations; Piperidines; Stereoisomerism; Substance P | 2002 |
Targeting opioid and neurokinin-1 receptors to treat alcoholism.
Topics: Alcoholism; Animals; Humans; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Opioid Peptides; Piperidines; Receptors, Neurokinin-1; Receptors, Opioid; Substance P | 2011 |
3 trial(s) available for substance p and piperidines
| Article | Year |
|---|---|
Neurokinin-1 receptor antagonist R116301 inhibits substance P-induced venodilation.
Topics: Administration, Oral; Adult; Area Under Curve; Butanols; Cross-Over Studies; Double-Blind Method; Hand; Humans; Malates; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Reference Values; Substance P; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Veins | 1999 |
Substance P (Neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures.
Topics: Administration, Oral; Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hysterectomy; Injections, Intravenous; Neurokinin-1 Receptor Antagonists; Ondansetron; Piperidines; Placebos; Postoperative Nausea and Vomiting; Preanesthetic Medication; Risk Factors; Serotonin Antagonists; Substance P | 2000 |
A selective neurokinin-1 receptor antagonist in chronic PTSD: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
Topics: Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Placebos; Psychiatric Status Rating Scales; Stress Disorders, Post-Traumatic; Substance P; Tetrazoles; Time Factors; Treatment Outcome; Young Adult | 2011 |
445 other study(ies) available for substance p and piperidines
| Article | Year |
|---|---|
Effects of piperine on the motility of the isolated guinea-pig ileum: comparison with capsaicin.
Topics: Alkaloids; Animals; Anticonvulsants; Atropine; Benzodioxoles; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Endings; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Ruthenium Red; Substance P; Tachyphylaxis; Tetrodotoxin | 1990 |
Autoradiographic visualization of NK-3 tachykinin binding sites in the rat brain, utilizing [3H]senktide.
Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Brain; Kinetics; Male; Organ Specificity; Paroxetine; Peptide Fragments; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Reference Values; Serotonin Antagonists; Substance P; Tachykinins; Tritium | 1990 |
On the nature of the contractile motor responses of the rat stomach elicited by serotonin or substance P in vitro.
Topics: Animals; Atropine; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Stomach; Substance P; Tachyphylaxis; Tetrodotoxin | 1985 |
The pentagastrin test in the diagnosis of the carcinoid syndrome.
Topics: Carcinoid Tumor; Female; Gastrointestinal Neoplasms; Humans; Hydroxyindoleacetic Acid; Ketanserin; Male; Malignant Carcinoid Syndrome; Pentagastrin; Piperidines; Receptors, Serotonin; Serotonin Antagonists; Substance P; Time Factors | 1985 |
Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide.
Topics: Amiloride; Animals; Bombesin; Calcium; Carbachol; Carrier Proteins; Cell Membrane Permeability; Chickens; Chinchilla; Dose-Response Relationship, Drug; Gallopamil; Ileum; Intestinal Mucosa; Loperamide; Neurotensin; Piperidines; Serotonin; Sodium-Hydrogen Exchangers; Substance P; Trifluoperazine | 1986 |
Effect of cisapride on the concentrations of beta-endorphinlike immunoreactivity and substance P-like immunoreactivity in the rat gastrointestinal tract.
Topics: Animals; beta-Endorphin; Cisapride; Cross Reactions; Digestive System; Intestinal Mucosa; Male; Muscle, Smooth; Piperidines; Radioimmunoassay; Rats; Substance P | 1987 |
Possible involvement of 5-lipoxygenase products in the generation of endothelium-derived relaxing factor.
Topics: Acetylcholine; Animals; Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Benzoquinones; Biological Assay; Biological Factors; Dogs; Endothelium, Vascular; Hydroquinones; In Vitro Techniques; Lipoxygenase Inhibitors; Nitric Oxide; Piperidines; Pyrogallol; Quinones; Spectrum Analysis; Substance P; Superoxide Dismutase; Vasodilation | 1989 |
Histamine H3-receptors modulate nonadrenergic noncholinergic neural bronchoconstriction in guinea-pig in vivo.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bronchi; Guinea Pigs; Histamine; In Vitro Techniques; Male; Methylhistamines; Phentolamine; Piperidines; Receptors, Histamine; Respiration; Substance P | 1989 |
The pentagastrin test in the diagnosis of the carcinoid syndrome. Blockade of gastrointestinal symptoms by ketanserin.
Topics: Aged; Calcium; Digestive System; Female; Humans; Ketanserin; Liver Neoplasms; Male; Malignant Carcinoid Syndrome; Middle Aged; Pentagastrin; Piperidines; Serotonin; Serotonin Antagonists; Substance P; Vasomotor System | 1985 |
Effect of intrathecal capsaicin analogues on the immunofluorescence of peptides and serotonin in the dorsal horn in rats.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Cholecystokinin; Enkephalin, Methionine; Fatty Acids, Unsaturated; Ganglia, Spinal; Kainic Acid; Male; Microscopy, Fluorescence; Nociceptors; Peptides; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Somatostatin; Substance P | 1983 |
Pharmacological characterization of LY303870: a novel, potent and selective nonpeptide substance P (neurokinin-1) receptor antagonist.
Topics: Airway Resistance; Animals; Binding, Competitive; Bronchi; Capillary Permeability; Cells, Cultured; Guinea Pigs; Humans; Indoles; Inositol Phosphates; Interleukin-6; Male; Muscle, Smooth, Vascular; Oligopeptides; Piperidines; Rabbits; Rats; Receptors, Neurokinin-1; Substance P; Trachea; Vasodilator Agents | 1995 |
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Modulation of acetylcholine, capsaicin and substance P effects by histamine H3 receptors in isolated perfused rabbit lungs.
Topics: Acetylcholine; Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Endothelium; Female; Histamine Agonists; Histamine Antagonists; Imidazoles; In Vitro Techniques; Lung; Male; Nerve Fibers; Piperidines; Pulmonary Edema; Rabbits; Receptors, Histamine H3; Serotonin; Substance P; Thiourea | 1995 |
Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.
Topics: Animals; Ferrets; Male; Neurokinin A; Piperidines; Stereoisomerism; Substance P; Vomiting | 1993 |
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection | 1993 |
In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
Topics: Animals; Brain; Bronchoconstriction; Capillary Permeability; Cell Line; Dogs; Endothelium, Vascular; Guinea Pigs; Humans; Hypotension; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1993 |
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Cell Line; Dipeptides; Humans; Indoles; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1994 |
SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
Topics: Astrocytoma; Binding, Competitive; Calcium; Electric Conductivity; Genes, fos; Humans; Inositol Phosphates; Iodine Radioisotopes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Succinimides; Taurine; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1994 |
Effects of antiallergic agents including levocabastine on experimental rhinitis in rats.
Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Nasal Mucosa; Piperidines; Platelet Activating Factor; Rats; Rats, Wistar; Rhinitis; Substance P | 1994 |
Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gerbillinae; Harderian Gland; Indoles; Injections, Intravenous; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P | 1994 |
Capsaicin-induced bladder hyperactivity in normal conscious rats.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Dose-Response Relationship, Drug; Female; Hexamethonium; Hexamethonium Compounds; Indoles; Isoindoles; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1994 |
Tachykinin NK1 receptor subtypes in the rat urinary bladder.
Topics: Animals; Benzamides; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Sulfones; Tachykinins; Urinary Bladder | 1994 |
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins | 1994 |
NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.
Topics: Animals; Benzamides; Capillary Permeability; Evans Blue; Hindlimb; Indoles; Isoindoles; Joints; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synovial Fluid; Tachykinins | 1993 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists.
Topics: Animals; Behavior, Animal; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
Immunoreactive substance P and neurokinin A in the hypothalamus and anterior pituitary gland of Siberian and Syrian hamsters and of rats.
Topics: Animals; Benzamides; Cricetinae; Female; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Hypothalamus; In Vitro Techniques; Male; Mesocricetus; Neurokinin A; Ovariectomy; Phodopus; Photoperiod; Piperidines; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1994 |
Importance of parallel vectors and "hydrophobic collapse" of the aligned aromatic rings: discovery of a potent substance P antagonist.
Topics: Chemical Phenomena; Chemistry, Physical; Humans; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1994 |
Non-specific inhibition of dopamine receptor agonist-induced behaviour by the tachykinin NK1 receptor antagonist CP-99,994 in guinea-pigs.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Dopamine Agonists; Grooming; Guinea Pigs; Haloperidol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oxazines; Piperidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1994 |
An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.
Topics: Animals; Carbachol; Cell Line, Transformed; Dose-Response Relationship, Drug; Glutamic Acid; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Hypothalamus; Inositol Phosphates; Kinetics; Mice; Neurons; Neuropeptide Y; Piperidines; Pyrimidinones; Ranitidine; Receptors, Histamine H1; Serotonin; Substance P; Tritium | 1994 |
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
Characterisation of [125I][MePhe7]neurokinin B binding to tachykinin NK3 receptors: evidence for interspecies variance.
Topics: Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; Molecular Sequence Data; Neurokinin B; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Tachykinin; Regression Analysis; Substance P | 1994 |
Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors.
Topics: Animals; Benzamides; Calcium; Calcium-Transporting ATPases; CHO Cells; Cricetinae; Cricetulus; Estrenes; Fura-2; Humans; Inositol Phosphates; Manganese; Neurokinin A; Peptide Fragments; Piperidines; Pyrrolidinones; Receptors, Neurokinin-3; Ryanodine; Second Messenger Systems; Structure-Activity Relationship; Substance P; Tachykinins; Terpenes; Thapsigargin; Type C Phospholipases | 1994 |
Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo.
Topics: Animals; Arginine; Arterioles; Cheek; Cricetinae; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Tachykinins; Vasoconstriction; Vasodilation | 1994 |
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin | 1994 |
Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder.
Topics: Animals; Cardiovascular Physiological Phenomena; Cats; Electric Stimulation; Female; Gallbladder; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 1995 |
Molecular determinants of the species selectivity of neurokinin type 1 receptor antagonists.
Topics: Androstanes; Animals; Benzimidazoles; Dipeptides; Humans; Indoles; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P | 1995 |
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan | 1995 |
An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Catalase; Dexamethasone; Drug Interactions; Edema; Histamine; Indoles; Indomethacin; Injections, Intradermal; Injections, Intravenous; Isoindoles; Male; Piperidines; Rabbits; Regional Blood Flow; Ruthenium Red; Skin; Substance P; Vasodilator Agents | 1995 |
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder | 1995 |
Regulation of substance P release mediated via prejunctional histamine H3 receptors.
Topics: Animals; Capillary Permeability; Electric Stimulation; Histamine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; Nerve Endings; Neurons, Afferent; Perfusion; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H3; Receptors, Presynaptic; Sciatic Nerve; Stimulation, Chemical; Substance P | 1995 |
Effects of substance P on cardiovascular regulation in the rabbit.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Electric Stimulation; Heart Rate; Injections, Intra-Arterial; Injections, Intraventricular; Male; Piperidines; Quinuclidines; Rabbits; Substance P; Vertebral Artery | 1995 |
Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344.
Topics: Animals; Biphenyl Compounds; Cats; Hot Temperature; Hypnotics and Sedatives; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Nociceptors; Piperidines; Spinal Cord; Spinal Nerve Roots; Substance P | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.
Topics: Animals; Benzamides; Calcium; Cell Line; Kinetics; Mice; Neuroblastoma; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured | 1995 |
Effects of CP-99,994, an NK1-receptor antagonist, on the inward current produced by substance P.
Topics: Animals; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Piperidines; Rana catesbeiana; Rats; Substance P | 1995 |
Substance P-induced histamine release in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Mast Cells; Perfusion; Piperidines; Pyrilamine; Receptors, Histamine; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Identification of residues involved in ligand binding to the neurokinin-2 receptor.
Topics: Amino Acid Sequence; Benzamides; Binding Sites; DNA Mutational Analysis; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Phosphatidylinositols; Piperidines; Receptors, Neurokinin-2; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Substance P; Tachykinins | 1995 |
Involvement of tachykinins in plasma extravasation induced by bradykinin and low pH medium in the guinea-pig conjunctiva.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Conjunctiva; Guinea Pigs; Hydrogen-Ion Concentration; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Bradykinin; Substance P; Tachykinins | 1995 |
The anti-emetic effects of CP-99,994 in the ferret and the dog: role of the NK1 receptor.
Topics: Animals; Antiemetics; Brain Stem; Dogs; Ferrets; Gagging; Indoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tropisetron; Vagus Nerve | 1995 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Activity of SR 142801 at peripheral tachykinin receptors.
Topics: Analysis of Variance; Animals; Binding, Competitive; Capsaicin; Cricetinae; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Portal Vein; Pulmonary Artery; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 1995 |
Corticotropin-releasing factor inhibits antigen-induced plasma extravasation in airways.
Topics: Animals; Capillary Permeability; Corticotropin-Releasing Hormone; Glycopeptides; Guinea Pigs; Hemodynamics; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Respiratory Physiological Phenomena; Respiratory System; Substance P; Tachykinins | 1995 |
The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea but not in the rat.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptosomes; Tachykinins; Type C Phospholipases | 1993 |
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Cricetinae; Duodenum; Guinea Pigs; In Vitro Techniques; Kinetics; Mesocricetus; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1993 |
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
Topics: Animals; Benzamides; Biphenyl Compounds; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Nociceptors; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P | 1993 |
Neurogenic vasodilation in the rat nasal mucosa involves neurokinin1 tachykinin receptors.
Topics: Animals; Capsaicin; Male; Neurons, Afferent; Olfactory Mucosa; Piperidines; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Vasodilation | 1993 |
Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
Topics: Animals; Autonomic Nervous System; Benzamides; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Nerve Endings; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
Topics: Animals; Benzamides; Binding Sites; Biphenyl Compounds; Cells, Cultured; Epitopes; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Hypertonic Solutions; Neurokinin A; Neurons, Afferent; Piperidines; Platelet Activating Factor; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium Chloride; Stimulation, Chemical; Substance P; Trachea; Tracheal Diseases | 1993 |
NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways.
Topics: Animals; Capsaicin; Inflammation; Male; Microspheres; Neurons, Afferent; Peptidyl-Dipeptidase A; Piperidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Regional Blood Flow; Respiratory System; Respiratory Tract Diseases; Substance P; Tachykinins; Vasodilation | 1993 |
SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo.
Topics: Animals; Blood-Brain Barrier; Brain; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Guinea Pigs; Ileum; Indoles; Male; Mice; Muscle Contraction; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Tropisetron | 1993 |
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
Topics: Adolescent; Adult; Aged; Atropine; Benzamides; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Esophagus; Glycopeptides; Humans; Isometric Contraction; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin | 1993 |
Neuroregulation of a chemosensitive afferent system in the canine distal esophagus.
Topics: Afferent Pathways; Animals; Atropine; Blood Pressure; Capsaicin; Chemoreceptor Cells; Dogs; Esophagus; Hexamethonium; Hexamethonium Compounds; Mucous Membrane; Nociceptors; Piperidines; Pressure; Pulse; Respiration; Substance P; Tetrodotoxin; Vagotomy | 1993 |
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder | 1993 |
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin | 1993 |
Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesis.
Topics: Animals; Benzamides; Biphenyl Compounds; Models, Neurological; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs.
Topics: Animals; Benzamides; Bronchial Spasm; Bronchoconstriction; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 1993 |
Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor.
Topics: Animals; Binding, Competitive; Calcium Channels; Capillary Permeability; Capsaicin; Cells, Cultured; Cricetinae; Guinea Pigs; Humans; In Vitro Techniques; Locus Coeruleus; Male; Motor Activity; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Species Specificity; Substance P | 1993 |
Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.
Topics: Amino Acid Sequence; Animals; Autoradiography; Brain; Guinea Pigs; Male; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Radioligand Assay; Stereoisomerism; Substance P | 1993 |
Identification of both NK1 and NK2 receptors in guinea-pig airways.
Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea | 1993 |
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
Topics: Animals; Benzamides; Blood Pressure; Bronchi; Capillary Permeability; Capsaicin; Cimetidine; Coloring Agents; Dose-Response Relationship, Drug; Evans Blue; Histamine Antagonists; Indoles; Inflammation; Isoindoles; Methysergide; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Neurokinin-1; Serotonin; Serotonin Antagonists; Substance P; Trachea | 1995 |
The involvement of calcitonin gene-related peptide (CGRP) and substance P in feline pial artery diameter responses evoked by capsaicin.
Topics: Anesthetics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cats; Cerebral Arteries; Female; Injections, Intravenous; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Substance P; Trigeminal Nerve; Vasomotor System | 1995 |
Neuropeptide modulation of chemically induced skin irritation.
Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission | 1995 |
Neuronal tachykinin NK2 receptors mediate release of non-adrenergic non-cholinergic inhibitory transmitters in the circular muscle of guinea-pig colon.
Topics: Animals; Colon; Guinea Pigs; Male; Membrane Potentials; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzamides; Dipeptides; Ethanol; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ion Channels; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Plant Extracts; Plants, Medicinal; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
RP67580, a neurokinin1 receptor antagonist, decreased restraint stress-induced defecation in rat.
Topics: Analgesics; Animals; Benzamides; Capsaicin; Defecation; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Restraint, Physical; Stereoisomerism; Stress, Psychological; Substance P | 1995 |
In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
Topics: Amino Acid Sequence; Animals; Asthma; Bronchoconstriction; Capillary Permeability; Guinea Pigs; Humans; Inositol Phosphates; Male; Methacholine Chloride; Mice; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Rats; Receptors, Neurokinin-2; Respiration; Species Specificity; Substance P | 1996 |
Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.
Topics: Animals; Blood Pressure; Capillary Permeability; Dogs; Female; Guinea Pigs; Humans; Locus Coeruleus; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Salivation; Substance P | 1996 |
2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.
Topics: Animals; Binding, Competitive; CHO Cells; Ciliary Body; Cricetinae; Cricetulus; Drug Design; Guinea Pigs; Humans; Muscle Contraction; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Structure-Activity Relationship; Substance P | 1996 |
Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma.
Topics: Amino Acid Sequence; Benzamides; Biphenyl Compounds; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Chemokine CCL4; Connective Tissue; Depression, Chemical; Erythroid Precursor Cells; Hematopoietic Stem Cells; Humans; Macrophage Inflammatory Proteins; Molecular Sequence Data; Monokines; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transforming Growth Factor beta | 1996 |
Involvement of NK1 and NK2 receptors in pulmonary responses elicited by non-adrenergic, non-cholinergic vagal stimulation in guinea-pigs.
Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Capillary Permeability; Enalapril; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Thiorphan; Trachea; Vagus Nerve | 1995 |
Effects of cisapride on feline colonic smooth muscle function.
Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channels; Cats; Cholecystokinin; Cholinergic Agonists; Cisapride; Colon; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Neurotensin; Nifedipine; Piperidines; Substance P; Tetrodotoxin | 1996 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageenan; Hyperalgesia; Iontophoresis; Kaolin; Knee Joint; Male; Neurokinin A; Nociceptors; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Spinal Cord; Substance P | 1996 |
The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist.
Topics: Animals; Binding, Competitive; Brain; Cattle; Cells, Cultured; Cerebral Arteries; CHO Cells; Cricetinae; Dogs; Ferrets; Gerbillinae; Hemodynamics; Humans; Ileum; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Portal Vein; Rabbits; Rats; Receptors, Neurotransmitter; Substance P; Tetrazoles; Transfection | 1995 |
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrilamine; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin Diseases; Spider Venoms; Substance P | 1996 |
Substance P hyperpolarizes vagal sensory neurones of the ferret.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Benzamides; Biphenyl Compounds; Cations, Divalent; Cesium; Electrophysiology; Ferrets; In Vitro Techniques; Male; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quaternary Ammonium Compounds; Receptors, Tachykinin; Substance P; Vagus Nerve | 1996 |
Augmentation of neurally evoked cholinergic bronchoconstrictor responses by prejunctional NK2 receptors in the guinea-pig.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Medulla Oblongata; Methacholine Chloride; Muscle, Smooth; Neurokinin A; Neurokinin B; Piperidines; Substance P | 1996 |
In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.
Topics: Adrenergic Agents; Animals; Colon; Dose-Response Relationship, Drug; Guanethidine; Hexamethonium; Male; Muscle Contraction; Neurokinin A; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Effect of SR 142801 on nitric oxide-dependent and independent responses to tachykinin NK3 receptor agonists in isolated guinea-pig colon.
Topics: Animals; Arginine; Colon; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P | 1995 |
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists.
Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P | 1996 |
[3H]LY303870, a novel nonpeptide radioligand for the NK-1 receptor.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cell Line; Corpus Striatum; Guinea Pigs; Humans; Indoles; Neurokinin-1 Receptor Antagonists; Piperidines; Substance P; Tissue Distribution; Tritium | 1996 |
Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin1 (NK1) receptor antagonist CP-99,994.
Topics: Animals; Antiemetics; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Morphine; Neurokinin A; Nicotine; Piperidines; Receptors, Neurokinin-1; Shrews; Stereoisomerism; Substance P; Vomiting | 1995 |
EFFECTS OF HISTAMINE AND RELATED COMPOUNDS ON THE BOVINE IRIS DILATOR.
Topics: Analysis of Variance; Animals; Cattle; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Ileum; Iris; Lethal Dose 50; Male; Methylhistamines; Muscle Contraction; Muscle, Smooth; p-Methoxy-N-methylphenethylamine; Piperidines; Potassium; Pyrilamine; Ranitidine; Receptors, Histamine H1; Substance P | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Effect of SR 140333, a selective NK1 antagonist, on antigen-induced oedema formation in rat skin.
Topics: Allergens; Animals; Edema; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin Diseases; Substance P | 1996 |
Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Injections, Intravenous; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Substance P | 1996 |
SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.
Topics: Animals; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs.
Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P | 1996 |
Interactions between acetylcholine and substance P effects on lung mechanics in the rabbit.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Histamine; Lung; Male; Muscle, Smooth; Perfusion; Piperidines; Pulmonary Circulation; Pulmonary Edema; Quinuclidines; Rabbits; Substance P; Vasoconstriction | 1996 |
Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
Topics: Animals; Capillary Permeability; Edema; Glycopeptides; Male; Mice; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Substance P | 1996 |
Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin NK3 receptor stimulation.
Topics: Adrenergic Fibers; Animals; Brain; Dose-Response Relationship, Drug; Gerbillinae; Guinea Pigs; Locus Coeruleus; Microdialysis; Neuropeptides; Norepinephrine; Peptide Fragments; Piperidines; Prazosin; Receptors, Neurokinin-3; Substance P | 1996 |
Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Female; Heart Rate; Male; Nasal Cavity; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Swine; Vasodilation | 1996 |
Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat.
Topics: Animals; Benzamides; Blood Pressure; Guinea Pigs; Hypotension; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
A water-soluble, stable dipeptide NK1 receptor-selective neurokinin receptor antagonist with potent in vivo pharmacological effects: S18523.
Topics: Animals; Bronchoconstriction; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Male; Mice; Neurokinin-1 Receptor Antagonists; Pain Measurement; Piperidines; Rabbits; Rats; Receptors, Neurokinin-1; Substance P; Tetrazoles | 1996 |
Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury.
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Edema; Male; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Skin; Substance P | 1996 |
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Postural Balance; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1996 |
Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils.
Topics: Animals; Female; Foot; Formaldehyde; Gerbillinae; Injections; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Nociceptors; Peptide Fragments; Piperidines; Stereoisomerism; Substance P; Time Factors | 1996 |
Localization and activation of substance P receptors in unmyelinated axons of rat glabrous skin.
Topics: Animals; Axons; Behavior, Animal; Foot; Hyperalgesia; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin; Staining and Labeling; Substance P; Tissue Distribution | 1996 |
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P | 1996 |
The role of substance P in myocardial dysfunction during ischemia and reperfusion.
Topics: Analgesics; Animals; Capsaicin; Guinea Pigs; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Piperidines; Substance P; Ventricular Dysfunction, Left | 1996 |
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1996 |
Role of substance P in the modulation of C-fiber-evoked responses of spinal dorsal horn neurons.
Topics: Animals; Evoked Potentials; Iontophoresis; Male; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Neurokinin receptors in the guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists.
Topics: Astrocytes; Humans; Interleukin-1; Interleukin-8; Monocytes; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Substance P; Tumor Cells, Cultured | 1996 |
Aerosolized tachykinin antagonists inhibit pentamidine-induce bronchoconstriction in guinea pigs.
Topics: Aerosols; Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Male; Pentamidine; Piperidines; Receptors, Neurokinin-2; Substance P | 1996 |
LY303870, a centrally active neurokinin-1 antagonist with a long duration of action.
Topics: Animals; Drug Synergism; Electroshock; Formaldehyde; Guinea Pigs; Humans; Indoles; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex, Startle; Species Specificity; Spinal Cord; Substance P | 1997 |
Transglutaminase-synthesized spermine derivative of substance P recognizes rat portal vein neurokinin-3 receptors.
Topics: Androstanes; Animals; Benzimidazoles; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Physalaemin; Piperidines; Portal Vein; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Thiorphan; Transglutaminases; Vasoconstriction | 1997 |
Topical substance P and corneal epithelial wound closure in the rabbit.
Topics: Administration, Topical; Animals; Cornea; Corneal Injuries; Epithelium; Male; Neurokinin A; Ophthalmic Solutions; Piperidines; Rabbits; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Wound Healing | 1997 |
Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation.
Topics: Adenoviruses, Human; Animals; Capillary Permeability; Capsaicin; Dexamethasone; Ficusin; Gene Transfer Techniques; Genetic Vectors; Glucocorticoids; Hot Temperature; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Photosensitizing Agents; Piperidines; Protein Denaturation; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Respiratory System; Substance P; Ultraviolet Rays | 1997 |
Evidence for modulation of dopamine-neuronal function by tachykinin NK3 receptor stimulation in gerbil mesencephalic cell cultures.
Topics: Animals; Calcium; Cells, Cultured; Dopamine; Gerbillinae; Intracellular Membranes; Mesencephalon; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
The effect of CP-99994 on the responses to provocative motion in the cat.
Topics: Animals; Antiemetics; Area Under Curve; Binding, Competitive; Cats; Half-Life; Injections, Subcutaneous; Motion Sickness; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Vomiting | 1997 |
Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Benzamides; Electric Stimulation; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Phenoxybenzamine; Piperidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1997 |
Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea.
Topics: Animals; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Fragments; Physalaemin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea | 1997 |
Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.
Topics: Anesthetics; Animals; Benzamides; Blood Pressure; Calcitonin Gene-Related Peptide; Dura Mater; Indoles; Isoindoles; Male; Microscopy, Video; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Vasodilator Agents | 1997 |
Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P.
Topics: Animals; Biphenyl Compounds; Bradykinin; Indoles; Indomethacin; Isoindoles; Kidney; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Prostaglandins; Prostaglandins E; Rats; Rats, Sprague-Dawley; Substance P | 1997 |
The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.
Topics: Animals; Behavior, Animal; Capillary Permeability; Gerbillinae; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Male; Morpholines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Plethysmography, Whole Body; Radioligand Assay; Receptors, Neurokinin-2; Respiratory Mechanics; Substance P; Tachykinins | 1997 |
Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder.
Topics: Analgesics; Animals; Benzamides; Binding Sites; Inositol Phosphates; Male; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins; Tritium; Type C Phospholipases; Urinary Bladder | 1997 |
Mechanisms of electrolyte transport across the endometrium. II. Regulation by GRP and substance P.
Topics: Amiloride; Animals; Biological Transport; Cell Membrane Permeability; Electrolytes; Female; Gastrin-Releasing Peptide; Gastrointestinal Hormones; Ionomycin; Kinetics; Membrane Potentials; Models, Biological; Mucous Membrane; Myometrium; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Potassium; Substance P; Swine; Thapsigargin | 1997 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Tachykinin-induced activation of non-specific cation conductance via NK3 neurokinin receptors in guinea-pig intracardiac neurones.
Topics: Animals; Barium; Electrophysiology; Female; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins; Tetraethylammonium Compounds | 1997 |
In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Topics: Animals; In Vitro Techniques; Iris; Male; Miosis; Muscle Contraction; Muscle, Smooth; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 1997 |
Potencies of agonists acting at tachykinin receptors in the oestrogen-primed rat uterus: effects of peptidase inhibitors.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estradiol; Female; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins; Uterine Contraction; Uterus | 1997 |
Cellular pathways mediating tachykinin-evoked secretomotor responses in guinea pig ileum.
Topics: Animals; Capsaicin; Electric Stimulation; Evoked Potentials; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins | 1997 |
Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat.
Topics: Animals; Behavior, Animal; Cardiovascular System; Dogs; Indoles; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 1997 |
Localization of Fos-like immunoreactivity induced by the NK3 tachykinin receptor agonist, senktide, in the guinea-pig brain.
Topics: Animals; Behavior, Animal; Brain; Female; Guinea Pigs; Male; Neurons; Peptide Fragments; Piperidines; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-3; Substance P; Tyrosine 3-Monooxygenase | 1997 |
Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn.
Topics: Animals; Benzamides; Biphenyl Compounds; Cats; Iontophoresis; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Stereoisomerism; Substance P; Synapses | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
Topics: Amino Acid Sequence; Animals; Benzamides; Calcium; Calcium-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Ganglia, Spinal; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger; Substance P; Vascular Resistance; Vasodilation | 1997 |
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Substance P regulates Ih via a NK-1 receptor in vagal sensory neurons of the ferret.
Topics: Action Potentials; Animals; Benzamides; Cations; Ferrets; Ion Channel Gating; Ion Transport; Male; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Piperidines; Receptors, Neurokinin-1; Substance P; Vagus Nerve | 1998 |
The nonpeptide NK-1 receptor antagonists LY303870 and LY306740 block the responses of spinal dorsal horn neurons to substance P and to peripheral noxious stimuli.
Topics: Acetamides; Animals; Cats; Electric Stimulation; Indoles; Iontophoresis; Neurokinin-1 Receptor Antagonists; Neurons; Pain; Piperidines; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1998 |
[Tachykinin receptor subtypes involved in endothelium-dependent and -independent responses in rabbit intrapulmonary arteries].
Topics: Animals; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Artery; Rabbits; Receptors, Tachykinin; Substance P | 1997 |
Pharmacological profiles of new orally active nonpeptide tachykinin NK1 receptor antagonists.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Female; Gerbillinae; Guinea Pigs; Ileum; Male; Piperidines; Portal Vein; Rats; Rats, Wistar; Receptors, Tachykinin; Spinal Cord; Substance P; Vas Deferens | 1998 |
Two related neurokinin-1 receptor antagonists have overlapping but different binding sites.
Topics: Animals; Binding Sites; Biphenyl Compounds; COS Cells; Humans; Hypnotics and Sedatives; Models, Chemical; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1998 |
The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro.
Topics: Animals; Anti-Anxiety Agents; Gerbillinae; In Vitro Techniques; Motor Neurons; Neurokinin-1 Receptor Antagonists; Neuromuscular Depolarizing Agents; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinolines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1998 |
Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.
Topics: Animals; Calcium; Colon; Enteric Nervous System; Guinea Pigs; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Tachykinin; Substance P; Tachykinins | 1998 |
Activation of non-adrenergic non-cholinergic inhibitory pathways by endogenous and exogenous tachykinins in the ferret lower oesophageal sphincter.
Topics: Animals; Capsaicin; Electric Stimulation; Esophagogastric Junction; Female; Ferrets; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetrodotoxin | 1998 |
Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Coloring Agents; Data Interpretation, Statistical; Enalapril; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indicators and Reagents; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Organometallic Compounds; Piperidines; Quinuclidines; Substance P; Time Factors | 1998 |
Muscarinic inhibition of substance P induced ion secretion in piglet jejunum.
Topics: Animals; Atropine; Carbachol; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Gallamine Triethiodide; Histamine; Ion Transport; Jejunum; Mecamylamine; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Substance P; Swine; Time Factors | 1998 |
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve | 1998 |
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
Topics: Acetamides; Analgesics; Animals; Gene Expression Regulation; Genes, fos; Indoles; Isoindoles; Locus Coeruleus; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Restraint, Physical; Stereoisomerism; Stress, Physiological; Substance P; Synaptic Transmission | 1998 |
Substance P enhances NMDA channel function in hippocampal dentate gyrus granule cells.
Topics: Animals; Cells, Cultured; Dentate Gyrus; Ion Channel Gating; Male; Neurokinin-1 Receptor Antagonists; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P | 1998 |
5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine.
Topics: Animals; Benzofurans; Calcitonin Gene-Related Peptide; Gastrointestinal Motility; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Intestines; Peptide Fragments; Peristalsis; Piperidines; Rats; Reflex; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Vasoactive Intestinal Peptide | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
Tachykinin NK1 receptor-mediated vasorelaxation in human pulmonary arteries.
Topics: Dose-Response Relationship, Drug; Humans; Phenylephrine; Piperidines; Pulmonary Artery; Receptors, Neurokinin-1; Substance P; Vasoconstrictor Agents; Vasodilation | 1998 |
Substance P blockade with the potent and centrally acting antagonist GR205171 does not effect central trigeminal activity with superior sagittal sinus stimulation.
Topics: Afferent Pathways; Animals; Brain Mapping; Cats; Cranial Sinuses; Electric Stimulation; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptors; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Spinal Cord; Substance P; Synaptic Transmission; Tetrazoles; Trigeminal Nuclei | 1998 |
A method to measure dual NK1/NK2-antagonist activity in dogs.
Topics: Animals; Benzamides; Dogs; Male; Neurokinin A; Piperidines; Propofol; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory System; Substance P; Tachykinins | 1998 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction.
Topics: Acetylcholinesterase; Animals; Calcium; GTP-Binding Proteins; Muscarine; Muscle, Skeletal; Neostigmine; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rana pipiens; Receptors, Neurokinin-1; Schwann Cells; Substance P; Synapses; Virulence Factors, Bordetella | 1998 |
A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity.
Topics: Animals; Cell Survival; Corpus Striatum; Hippocampus; Kainic Acid; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Substance P; Tachykinins; Time Factors; Transcription, Genetic | 1998 |
Characterization of the mechanism of action of tachykinins in rat striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Chelating Agents; Corpus Striatum; Diazonium Compounds; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Interneurons; Male; Membrane Potentials; Patch-Clamp Techniques; Phenoxyacetates; Phosphodiesterase Inhibitors; Photochemistry; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 1998 |
Modulation by substance P of synaptic transmission in the mouse hippocampal slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mice; Microelectrodes; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tetrodotoxin; Time Factors | 1998 |
Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit.
Topics: Anesthesia; Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Drug Interactions; Glycopeptides; Neprilysin; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagus Nerve; Vasoconstriction | 1998 |
Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide.
Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Male; Muscle, Skeletal; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P | 1998 |
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages.
Topics: Animals; Antigens; Arachidonic Acid; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Endopeptidases; Glycopeptides; Guinea Pigs; Macrophage Activation; Macrophages, Alveolar; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1998 |
Serotonin unmasks functional NK-2 receptors in vagal sensory neurones of the guinea-pig.
Topics: Animals; Benzamides; Cycloheximide; Enzyme Inhibitors; Guinea Pigs; Hydrazines; Imidazoles; Indoles; Male; Membrane Potentials; Neurons, Afferent; Nitric Oxide; Nitric Oxide Donors; Nodose Ganglion; omega-N-Methylarginine; Penicillamine; Piperidines; Protein Synthesis Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; Tropisetron | 1999 |
Functional characterisation of tachykinin receptors mediating ion transport in porcine jejunum.
Topics: Animals; Binding, Competitive; Electric Stimulation; Evoked Potentials; Female; In Vitro Techniques; Indoles; Ion Transport; Isoindoles; Jejunum; Male; Membrane Potentials; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Swine | 1998 |
Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig.
Topics: Acetylcholine; Animals; Brain; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Male; Microdialysis; Nucleus Accumbens; Peptide Fragments; Piperidines; Prefrontal Cortex; Receptors, Neurokinin-3; Substance P; Substantia Nigra; Synaptic Transmission; Time Factors; Ventral Tegmental Area | 1998 |
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Edema; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Time Factors | 1998 |
Subthreshold concentration of endothelin-1-enhanced, capsaicin-induced bronchoconstriction in anaesthetized guinea-pigs.
Topics: Aerosols; Airway Resistance; Anesthesia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Guinea Pigs; Male; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Substance P | 1998 |
Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Neurokinin B; Neurons, Afferent; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Spinal Cord; Spinal Nerve Roots; Substance P | 1998 |
Endothelium-dependent contraction induced by substance P in canine cerebral arteries: involvement of NK1 receptors and thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Papaverine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Two affinities for a single antagonist at the neuronal NK1 tachykinin receptor: evidence from quantitation of receptor endocytosis.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Endocytosis; Female; Fluorescence; Guinea Pigs; Ileum; In Vitro Techniques; Male; Microscopy, Confocal; Neurokinin-1 Receptor Antagonists; Neurons; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 1999 |
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid | 1999 |
Neurogenic plasma leakage in mouse airways.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder | 1999 |
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.
Topics: Amino Acids; Analgesics; Animals; Dinoprostone; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1999 |
Decreased vascular permeability response to substance P in airways of genetically hypertensive rats.
Topics: Animals; Blood Pressure; Capillary Permeability; Capsaicin; Hypertension; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 1999 |
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors | 1999 |
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
Topics: Animals; Animals, Newborn; Body Temperature; Electric Stimulation; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Male; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Physical Stimulation; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spinal Cord; Substance P | 1999 |
Anti-emetic effects of a novel NK-1 receptor antagonist HSP-117 in ferrets.
Topics: Animals; Antiemetics; Benzofurans; Brain Stem; Cerebral Ventricles; Copper Sulfate; Emetics; Ferrets; In Vitro Techniques; Injections, Intraventricular; Male; Membrane Potentials; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Substance P; Vomiting | 1998 |
Role of neurokinin 3 receptors on responses to colorectal distention in the rat: electrophysiological and behavioral studies.
Topics: Animals; Colon; Electromyography; Gastrointestinal Motility; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscle Contraction; Pain Measurement; Peptide Fragments; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-3; Rectum; Sensory Thresholds; Substance P; Visceral Afferents | 1999 |
Internalization of the neurokinin 1 receptor in rat myenteric neurons.
Topics: Animals; Endocytosis; Hypertonic Solutions; Ileum; Immunohistochemistry; Male; Microscopy, Confocal; Monensin; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins | 1999 |
Involvement of substance P in the anti-inflammatory effects of the peripherally selective kappa-opioid asimadoline and the NK1 antagonist GR205171.
Topics: Acetamides; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Progression; Dose-Response Relationship, Drug; Joints; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Rats; Substance P; Tetrazoles | 1999 |
Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Electric Stimulation; Female; Ganglia, Spinal; Ganglia, Sympathetic; Hair; Hindlimb; Nerve Fibers; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P; Vasodilation | 1999 |
Neurokinin type-1 receptor antagonist inhibits enhancement of T cell functions by substance P in normal and neuromanipulated capsaicin-treated rats.
Topics: Animals; Capsaicin; CD4-Positive T-Lymphocytes; CD5 Antigens; Cell Division; Concanavalin A; Female; Interleukin-2; Lymphocyte Activation; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Specific Pathogen-Free Organisms; Spleen; Substance P | 1999 |
Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat.
Topics: Acetamides; Animals; Behavior, Animal; Blood Pressure; Capillary Permeability; Heart Rate; Indoles; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1999 |
Evidence for tonic activation of NK-1 receptors during the second phase of the formalin test in the Rat.
Topics: Animals; Autoradiography; Behavior, Animal; Electrophysiology; Formaldehyde; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Male; Neurons; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin; Spinal Cord; Substance P; Time Factors | 1999 |
Nanomolar concentrations of neuropeptides induce histamine release from peritoneal mast cells of a substrain of Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Histamine Release; Male; Mast Cells; Neurokinin A; Peritoneum; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Substance P; Tachykinins | 1999 |
Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice.
Topics: Animals; Hindlimb; Lysophospholipids; Male; Mice; Mice, Inbred Strains; Nerve Endings; Neurokinin-1 Receptor Antagonists; Pain; Peripheral Nerves; Pertussis Toxin; Piperidines; Stereoisomerism; Substance P; Time Factors; Virulence Factors, Bordetella | 1999 |
Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.
Topics: Aggression; Analgesics, Opioid; Animals; Antibodies, Blocking; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptin; Opioid Peptides; Piperidines; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Substance P | 1999 |
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.
Topics: Animals; Blood Proteins; Colitis; Dinitrofluorobenzene; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Peroxidase; Piperidines; Quinuclidines; Recombinant Proteins; Substance P | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Spinal opioid analgesia: how critical is the regulation of substance P signaling?
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Cells, Cultured; Embryo, Mammalian; Male; Morphine; Neurokinin-1 Receptor Antagonists; Pain; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P; Tetrazoles | 1999 |
Pharmacological differences and similarities between the native mouse 5-HT3 receptor in N1E-115 cells and a cloned short splice variant of the mouse 5-HT3 receptor expressed in HEK 293 cells.
Topics: Alternative Splicing; Animals; Binding, Competitive; Carbon Radioisotopes; Cell Line; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression; Genetic Variation; Guanidine; Humans; Hybrid Cells; Imidazoles; Indoles; Isoindoles; Membranes; Mice; Piperidines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Sequence Analysis, DNA; Serotonin; Serotonin Agents; Substance P; Transfection; Tritium; Tumor Cells, Cultured | 1999 |
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1999 |
Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bradycardia; Chemoreceptor Cells; Heart Rate; Losartan; Microinjections; Neurokinin-1 Receptor Antagonists; Phrenic Nerve; Piperidines; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reflex; Respiration; Respiratory Physiological Phenomena; Solitary Nucleus; Substance P | 1999 |
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.
Topics: Animals; Behavior, Animal; Brain; Cerebral Ventricles; Genes, fos; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Motor Activity; Neurokinin-1 Receptor Antagonists; Organ Specificity; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Substance P; Tyrosine 3-Monooxygenase | 1999 |
Nerve-mediated motility of ileal segments isolated from NK(1) receptor knockout mice.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Gastrointestinal Motility; Ileum; Male; Mice; Mice, Knockout; Neurokinin A; Neurons, Afferent; Nitric Oxide; Organ Culture Techniques; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-1; Substance P; Synaptic Transmission | 1999 |
Effect of non-peptide tachykinin NK(1) receptor antagonists on non-adrenergic, non-cholinergic neurogenic mucus secretion in ferret trachea.
Topics: Acetylcholine; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Ferrets; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; Mucus; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinolines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1999 |
Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.
Topics: Benzamides; Biphenyl Compounds; Bone Marrow Cells; Bone Marrow Neoplasms; Breast Neoplasms; Cell Division; Female; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Tumor Cells, Cultured | 2000 |
Antigen inhalation unmasks NK-2 tachykinin receptor-mediated responses in vagal afferents.
Topics: Animals; Antigens; Benzamides; Disease Models, Animal; Guinea Pigs; Male; Membrane Potentials; Microscopy, Electron, Scanning; Neurokinin-1 Receptor Antagonists; Ovalbumin; Patch-Clamp Techniques; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea; Tracheitis; Vagotomy; Vagus Nerve | 2000 |
Endothelin and free radicals modulate microvascular responses in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Electric Stimulation; Endothelin Receptor Antagonists; Endothelins; Free Radicals; Laser-Doppler Flowmetry; Male; Microcirculation; Nitroprusside; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sciatic Nerve; Skin; Streptozocin; Substance P; Superoxide Dismutase; Vasodilator Agents | 2000 |
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea | 1999 |
Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea-pig small intestine.
Topics: Adrenergic Agents; Animals; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Immunohistochemistry; Intestine, Small; Male; Myenteric Plexus; NADPH Dehydrogenase; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tetrodotoxin | 1999 |
Tachykinin NK(3)receptor involvement in anxiety.
Topics: Animals; Anxiety; Cerebral Ventricles; Injections, Intraventricular; Male; Maze Learning; Mice; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents | 1999 |
Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line.
Topics: Bronchi; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Transformed; Cytokines; Epithelial Cells; Gene Expression; Humans; Interleukin-6; Interleukin-8; Peptide Fragments; Piperidines; Protease Inhibitors; RNA, Messenger; Substance P; Thiorphan; Tumor Necrosis Factor-alpha | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
SR142801 behaves as a tachykinin NK-3 receptor agonist on a spinal nociceptive reflex in the rat.
Topics: Analgesics; Animals; Drug Interactions; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.
Topics: Analgesics; Animals; Benzamides; Evans Blue; Forelimb; Hyperthermia, Induced; Indoles; Inflammation; Isoindoles; Male; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Rats; Rats, Sprague-Dawley; Skin; Substance P | 2000 |
Endothelium-dependent relaxation followed by contraction mediated by NK(1) receptors in precontracted rabbit intrapulmonary arteries.
Topics: Animals; Benzamides; Benzoquinones; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Substance P | 2000 |
Facilitation of cholinergic transmission by substance P methyl ester in the mouse hippocampal slice preparation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Drug Synergism; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Tetrodotoxin; Valine | 2000 |
Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists.
Topics: Animals; Benzamides; Indoles; Isoindoles; Male; Microinjections; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Substance P; Tachykinins; Tidal Volume | 2000 |
Further evidence for the presence of "septide-sensitive" tachykinin binding sites in tissues possessing solely NK(1) tachykinin receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Humans; Indoles; Iodine Radioisotopes; Isoindoles; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protein Isoforms; Pyrrolidonecarboxylic Acid; Radioligand Assay; Rats; Receptors, Neurokinin-1; Substance P; Tetrazoles; Tumor Cells, Cultured | 2000 |
Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Physalaemin; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridoxal Phosphate; Receptors, Neurokinin-3; Sincalide; Substance P; Vasoactive Intestinal Peptide | 2000 |
NK-3 receptors are expressed on mouse striatal gamma-aminobutyric acid-ergic interneurones and evoke [(3)H] gamma-aminobutyric acid release.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; In Situ Hybridization; Interneurons; Mice; Mice, Inbred C57BL; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Piperidines; Protein Precursors; Receptors, Neurokinin-3; RNA, Messenger; Somatostatin; Substance P; Tachykinins | 2000 |
Neurokinin B- and specific tachykinin NK(3) receptor agonists-induced airway hyperresponsiveness in the guinea-pig.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstrictor Agents; Female; Guinea Pigs; Male; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins; Vasodilator Agents | 2000 |
Effect of the sensory neuropeptide antagonists h-CGRP((8-37)) and SR 140.33 on pulpal and gingival blood flow in ferrets.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dental Pulp; Electric Stimulation; Female; Ferrets; Gingiva; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Statistics, Nonparametric; Substance P | 2000 |
An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists.
Topics: Alcohols; Calorimetry; Diazonium Compounds; Magnetic Resonance Spectroscopy; Oxazoles; Piperidines; Stereoisomerism; Substance P | 2000 |
Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Buspirone; Diazepam; Dose-Response Relationship, Drug; Female; Fluoxetine; Gene Deletion; Guinea Pigs; Imipramine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Social Isolation; Stress, Psychological; Substance P; Tetrazoles; Vocalization, Animal | 2000 |
Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists.
Topics: Animals; Diestrus; Estrogens; Estrus; Female; Metestrus; Neurokinin A; Ovariectomy; Peptide Fragments; Piperidines; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Uterine Contraction | 2000 |
The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis.
Topics: Animals; Antiemetics; Antineoplastic Agents; Benzofurans; Chemoreceptor Cells; Cisplatin; Copper Sulfate; Drug Interactions; Ferrets; Fourth Ventricle; Male; Medulla Oblongata; Morphine; Narcotics; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Proto-Oncogene Proteins c-fos; Radioligand Assay; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Tachykinins; Tritium; Vomiting | 2000 |
Participation of neuropeptides in antigen-induced contraction of guinea pig bronchi via NK(2) but not NK(1) receptor stimulation.
Topics: Animals; Benzamides; Benzeneacetamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Female; gamma-Globulins; Guinea Pigs; Histamine H1 Antagonists; Leukotriene Antagonists; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Penicillin G; Piperidines; Pyrilamine; Receptors, Neurokinin-2; Substance P; Thiazoles; Trachea | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Regional differences in neurogenic signal transduction pathway of cholera toxin-induced fluid, electrolyte and serotonin accumulation in the porcine jejunum.
Topics: Animals; Body Fluids; Cholera Toxin; Dose-Response Relationship, Drug; Electrolytes; Female; Hexamethonium; Jejunum; Nicotinic Antagonists; Ondansetron; Piperidines; Receptors, Neurokinin-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Signal Transduction; Substance P; Swine | 2000 |
Substance P radioimmunoassay for quantitative characterization of sensory neurotransmitter release.
Topics: Alkaloids; Animals; Benzodioxoles; Calibration; Capsaicin; Diterpenes; Electric Stimulation; Enzyme Inhibitors; Female; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Radioimmunoassay; Rats; Rats, Wistar; Stimulation, Chemical; Substance P; Trachea | 1999 |
Sexually dimorphic regulation of NK-1 receptor-mediated electrophysiological responses in vagal primary afferent neurons.
Topics: Animals; Benzamides; Electrophysiology; Estradiol; Female; Gonadal Steroid Hormones; Guinea Pigs; Male; Membrane Potentials; Neurons, Afferent; Nodose Ganglion; Orchiectomy; Ovariectomy; Piperidines; Pregnancy; Quinolines; Receptors, Neurokinin-1; Serotonin; Sex Characteristics; Substance P; Testosterone | 2000 |
Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK(1) receptor numbers.
Topics: Animals; Binding, Competitive; Capillary Permeability; Diterpenes; Hypertension; Inflammation; Male; Membranes; Piperidines; Quinuclidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Spinal Cord; Substance P; Trachea; Tritium | 2000 |
Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.
Topics: Animals; Antibodies; Blood Proteins; Bronchial Hyperreactivity; Cyclophosphamide; Electric Stimulation; Eosinophil Granule Proteins; Female; Guinea Pigs; Heparin; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Ribonucleases; Substance P; Vagus Nerve | 2000 |
Unique gradual and sustained vasodilator response to substance P in the rabbit knee joint.
Topics: Administration, Topical; Animals; Benzamides; Cyclooxygenase Inhibitors; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Flurbiprofen; Hindlimb; Indoles; Injections, Intra-Articular; Joints; Neurokinin-1 Receptor Antagonists; Piperidines; Rabbits; Receptors, Neurokinin-2; Regional Blood Flow; Substance P; Vasodilation | 2000 |
Diastereoselective intramolecular Ritter reaction: generation of a cis-fused hexahydro-4aH-indeno[1,2-b]pyridine ring system with 4a,9b-diangular substituents.
Topics: Biphenyl Compounds; Chromatography, Thin Layer; Crystallography, X-Ray; Cyclization; Magnetic Resonance Spectroscopy; Molecular Structure; Neurokinin-1 Receptor Antagonists; Piperidines; Pyridines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 2000 |
Neural pathways regulating Brunner's gland secretion in guinea pig duodenum in vitro.
Topics: Animals; Brunner Glands; Capsaicin; Carbachol; Choline O-Acetyltransferase; Cholinergic Agonists; Cholinergic Fibers; Dimethylphenylpiperazinium Iodide; Duodenum; Electric Stimulation; Female; Ganglia, Sympathetic; Guanethidine; Guinea Pigs; Hexamethonium; In Vitro Techniques; Male; Muscarinic Antagonists; Neural Pathways; Neurotransmitter Agents; Nicotinic Agonists; Nicotinic Antagonists; Piperidines; Submucous Plexus; Substance P; Sympatholytics; Tetrodotoxin; Vagotomy; Vagus Nerve | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature | 2000 |
Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Time Factors | 2000 |
The tachykinin NK(1) receptor antagonist SR140333 prevents the increase of nerve growth factor in rat paw skin induced by substance P or neurogenic inflammation.
Topics: Animals; Hindlimb; Injections; Male; Nerve Growth Factor; Neurogenic Inflammation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Skin; Substance P | 2000 |
NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cattle; Dose-Response Relationship, Drug; Gerbillinae; Hindlimb; Humans; Inhibitory Concentration 50; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Binding; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Social Behavior; Species Specificity; Substance P; Tumor Cells, Cultured | 2000 |
Differential role of neurokinin receptors in human lymphocyte and monocyte chemotaxis.
Topics: Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Indoles; Inflammation; Monocytes; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; T-Lymphocytes | 2000 |
Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Gerbillinae; Guinea Pigs; Male; Membranes; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-3; Species Specificity; Substance P | 2001 |
Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Capsaicin; Croton Oil; Dermatitis, Allergic Contact; Dermatitis, Irritant; Enzyme Inhibitors; Female; Glycopeptides; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Skin; Substance P | 2001 |
Exaggerated neurogenic inflammation and substance P receptor upregulation in RSV-infected weanling rats.
Topics: Animals; Antibodies, Monoclonal; Body Weight; Cell Line; DNA Primers; Humans; Immunoenzyme Techniques; Lung; Neurogenic Inflammation; Neuropeptides; Piperidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Vasoactive Intestinal Peptide; Respiratory Syncytial Virus Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Up-Regulation | 2001 |
Tachykinins contribute to nerve-mediated contractions in the human esophagus.
Topics: Atropine; Autonomic Nervous System; Benzamides; Dose-Response Relationship, Drug; Esophagus; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Parasympatholytics; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Immunohistochemical demonstration of the NK(1) tachykinin receptor on muscle and epithelia in guinea pig intestine.
Topics: Animals; Carbocyanines; Colon; Endocytosis; Epithelial Cells; Female; Fluorescent Dyes; Guinea Pigs; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Rectum; Substance P | 2001 |
Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Intracellular Fluid; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P; Tetrazoles | 2001 |
Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat.
Topics: Analgesics; Animals; Bee Venoms; Consciousness; Disease Models, Animal; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P | 2001 |
Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons.
Topics: Action Potentials; Animals; Biotin; Coloring Agents; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Guinea Pigs; Image Processing, Computer-Assisted; Immune Sera; Male; Microelectrodes; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Protein Kinase C; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Sympathetic Fibers, Postganglionic; Tachykinins | 2001 |
Role of intrinsic airway neurons in ozone-induced airway hyperresponsiveness in ferret trachea.
Topics: Acetylcholine; Animals; Cholinergic Agonists; Culture Techniques; Electric Stimulation; Female; Ferrets; Methacholine Chloride; Muscarinic Agonists; Neurokinin-1 Receptor Antagonists; Neurons; Ozone; Piperidines; Substance P; Trachea; Tracheal Diseases | 2001 |
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
Topics: Administration, Oral; Animals; Bronchoconstriction; Cricetinae; Guinea Pigs; Humans; Ileum; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Sulfoxides | 2001 |
Gabapentin inhibits the substance P-facilitated K(+)-evoked release of [(3)H]glutamate from rat caudial trigeminal nucleus slices.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neurokinin-1 Receptor Antagonists; Organ Culture Techniques; Piperidines; Potassium; Pregabalin; Rats; Rats, Inbred Strains; Stereoisomerism; Substance P; Trigeminal Nucleus, Spinal; Tritium | 2001 |
Contribution of NK3 tachykinin receptors to propulsion in the rabbit isolated distal colon.
Topics: Animals; Colon; Complement C6; Dose-Response Relationship, Drug; Gastrointestinal Motility; In Vitro Techniques; Male; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 2001 |
Tachykinins mediate slow excitatory postsynaptic transmission in guinea pig sphincter of Oddi ganglia.
Topics: Animals; Calcium; Capsaicin; Culture Techniques; Excitatory Postsynaptic Potentials; Female; Ganglia; Guinea Pigs; Male; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Sphincter of Oddi; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 2001 |
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.
Topics: Animals; Antidiarrheals; Capsaicin; Colitis, Ulcerative; Colon; Crohn Disease; Epithelial Cells; Food Hypersensitivity; Guinea Pigs; Humans; Immunoglobulin E; Inflammatory Bowel Diseases; Male; Mast Cells; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P; Tachykinins | 2001 |
Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats.
Topics: Animals; Behavior, Animal; Capillary Permeability; Capsaicin; Chlorpheniramine; Dose-Response Relationship, Drug; Glycopeptides; Histamine; Histamine H1 Antagonists; Indoles; Injections, Intradermal; Male; Mast Cells; Methysergide; Neurons, Afferent; Peptides; Piperidines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Skin; Substance P | 2001 |
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine | 2001 |
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water | 2001 |
Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists.
Topics: Animals; Autoradiography; Beta Particles; Brain; Central Nervous System; Dose-Response Relationship, Drug; Gerbillinae; Male; Peptide Fragments; Piperidines; Radionuclide Imaging; Receptors, Neurokinin-3; Substance P | 2001 |
Effects of CP-99, 994, a tachykinin NK(1) receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK(1) and 5-HT(3) receptors.
Topics: Abdomen; Animals; Dose-Response Relationship, Drug; Ferrets; Granisetron; Injections, Intravenous; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Stereoisomerism; Substance P; Vagus Nerve | 2001 |
Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.
Topics: Acetylcholine; Aged; Benzamides; Bronchi; Cholinergic Fibers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Neurokinin A; Piperidines; Protein Precursors; Radioimmunoassay; Receptors, Neurokinin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Vasodilator Agents | 2001 |
Modulation of cardiac activity by tachykinins in the rat substantia nigra.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Atropine; Benzamides; Blood Pressure; Hemodynamics; Indoles; Isoindoles; Male; Microinjections; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachycardia; Tachykinins | 2001 |
Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiemetics; Dose-Response Relationship, Drug; Guinea Pigs; Locus Coeruleus; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Peptide Fragments; Piperidines; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tetrazoles | 2002 |
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P | 2001 |
CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Mice; Nociceptors; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Neurokinin-1; Rimonabant; Spinal Cord; Substance P | 2002 |
Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats.
Topics: Altitude; Animals; Blood Pressure; Blood Vessels; Capillaries; Chronic Disease; Female; Hypoxia; In Vitro Techniques; Piperidines; Pulmonary Circulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors | 2002 |
Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids.
Topics: Animals; Colon; Female; Gonadal Steroid Hormones; Histamine Release; Hormone Antagonists; Mifepristone; Neurokinin-1 Receptor Antagonists; Ovary; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Restraint, Physical; Stress, Psychological; Substance P | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist.
Topics: Animals; CHO Cells; Cricetinae; Gerbillinae; Guinea Pigs; Humans; Methylurea Compounds; Motor Activity; Neurokinin B; Peptide Fragments; Piperidines; Rabbits; Rats; Receptors, Neurokinin-3; Substance P | 2002 |
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death.
Topics: Animals; Annexin A5; Apoptosis; Caspase Inhibitors; Caspases; Cell Size; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fetus; Humans; Immunohistochemistry; Kidney; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Prosencephalon; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tryptophan | 2002 |
Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia.
Topics: Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Trachea; Vagotomy; Vagus Nerve | 2002 |
Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist.
Topics: Administration, Oral; Allergens; Animals; Butanols; Capsaicin; Cats; Dogs; Edema; Ferrets; Gerbillinae; Guinea Pigs; Histamine; Kinetics; Malates; Mice; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Platelet Activating Factor; Rabbits; Receptors, Neurokinin-1; Salivation; Substance P; Time Factors | 2002 |
Antagonism by NKP608 of substance P-induced plasma protein exudation in a novel preparation of perfused trachea in rats and guinea-pigs in vivo.
Topics: Animals; Blood Proteins; Dose-Response Relationship, Drug; Exudates and Transudates; Guinea Pigs; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachyphylaxis; Trachea | 2002 |
Triptans reduce the inflammatory response in bacterial meningitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Calcitonin Gene-Related Peptide; Cerebrovascular Circulation; Dura Mater; Humans; Indoles; Laser-Doppler Flowmetry; Leukocytes; Male; Meningitis, Pneumococcal; Mice; Mice, Inbred Strains; Oxadiazoles; Oxazolidinones; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Survival Rate; Tryptamines | 2002 |
Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.
Topics: Animals; Antipsychotic Agents; Benzamides; Cyclooxygenase Inhibitors; Edema; Enzyme Inhibitors; Extravascular Lung Water; Female; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Piperidines; Plasma; Pulmonary Edema; Receptors, Neurokinin-1; Substance P | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex.
Topics: Animals; Baroreflex; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Microinjections; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neurokinin-1; Solitary Nucleus; Substance P | 2002 |
Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain.
Topics: Androstanes; Animals; Autoradiography; Benzimidazoles; Binding Sites; Brain; Brain Chemistry; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fever; Glial Fibrillary Acidic Protein; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Piperidines; Signal Transduction; Substance P; Tyrosine 3-Monooxygenase | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indoles; Injections, Spinal; Isoindoles; Male; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P | 2003 |
Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat.
Topics: Animals; Baroreflex; Blood Pressure; Diterpenes; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Rest; Substance P; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Male; Neuropeptides; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Somatostatin; Substance P; Trachea | 2003 |
Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea.
Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Electric Stimulation; Mice; Mice, Knockout; Muscle Contraction; Parasympathetic Nervous System; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 2003 |
Antiemetic effect of a tachykinin NK1 receptor antagonist GR205171 on cisplatin-induced early and delayed emesis in the pigeon.
Topics: Animals; Antiemetics; Cisplatin; Columbidae; Female; Immunohistochemistry; Injections, Intramuscular; Injections, Intravenous; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Solitary Nucleus; Substance P; Tetrazoles; Vagus Nerve; Vomiting | 2003 |
Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS.
Topics: Animals; Benzamides; Biphenyl Compounds; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Female; Free Radical Scavengers; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Pelvis; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Neurokinin-1; Reflex, Abnormal; Signal Transduction; Sodium Chloride; Substance P; Superoxide Dismutase; Urinary Bladder; Urinary Bladder, Neurogenic; Urination; Visceral Afferents | 2003 |
Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats.
Topics: Adjuvants, Immunologic; Animals; Asthma; Leukocyte Count; Lung; Lymphocyte Subsets; Male; Monocytes; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pneumonia, Viral; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Specific Pathogen-Free Organisms; Substance P | 2003 |
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Purinergic P2 Receptor Antagonists; Quinuclidines; Rabbits; Serotonin Antagonists; Substance P; Suramin; Trinitrobenzenesulfonic Acid | 2003 |
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.
Topics: Alanine; Animals; Atropine; Colon; Drug Interactions; Enzyme Inhibitors; Indoles; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peristalsis; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Substance P | 2003 |
Substance P released from intrinsic airway neurons contributes to ozone-enhanced airway hyperresponsiveness in ferret trachea.
Topics: Animals; Capsaicin; Electric Stimulation; Female; Ferrets; Ganglia; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neurons; Ozone; Piperidines; Substance P; Trachea | 2003 |
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzopyrans; Butyrates; Cyproheptadine; Dose-Response Relationship, Drug; Glutamic Acid; Histamine H2 Antagonists; Interferon-gamma; Interleukin-1; Male; Methysergide; Mice; Mice, Inbred ICR; Models, Chemical; Naloxone; Narcotic Antagonists; Pain; Piperidines; Protein Kinase C; Ranitidine; Receptors, Adrenergic; Receptors, Histamine; Receptors, Purinergic P1; Receptors, Serotonin; Serotonin Antagonists; Substance P; Theobromine; Tumor Necrosis Factor-alpha; Xanthines; Yohimbine | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii.
Topics: Animals; Baroreflex; GABA Agonists; Heart; Hindlimb; Isonicotinic Acids; Male; Microinjections; Nociceptors; Pain; Parasympathetic Nervous System; Physical Stimulation; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Sympathetic Nervous System; Tachycardia; Vagus Nerve | 2003 |
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2003 |
Diencephalic neurons producing melanin-concentrating hormone are influenced by local and multiple extra-hypothalamic tachykininergic projections through the neurokinin 3 receptor.
Topics: Animals; Brain; Colchicine; Feeding Behavior; Hypothalamic Hormones; Hypothalamus; Interneurons; Male; Melanins; Neural Pathways; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Organ Culture Techniques; Peptide Fragments; Piperidines; Pituitary Hormones; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Sexual Behavior; Substance P; Tachykinins | 2003 |
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan | 2003 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles | 2003 |
Contribution of tachykinin receptor subtypes to micturition reflex in guinea pigs.
Topics: Animals; Brain; Catheterization; CHO Cells; Cricetinae; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Indoles; Injections, Intravenous; Iodine Radioisotopes; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Spinal Cord; Substance P; Succinimides; Tetrazoles; Tissue Extracts; Transfection; Urinary Bladder; Urination | 2003 |
Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P.
Topics: Aerosols; Age Factors; Animals; Brain Stem; Bronchoconstriction; Citric Acid; Cough; Guinea Pigs; Homocysteine; Injections; Lung; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiration; Solitary Nucleus; Substance P; Tobacco Smoke Pollution | 2004 |
A substance P receptor (NK1) antagonist enhances the widespread osteoporotic effects of sciatic nerve section.
Topics: Absorptiometry, Photon; Age Factors; Animals; Body Weight; Bone Density; Denervation; Diaphyses; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Femur; Foot; Hindlimb; Indoles; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Osteoporosis; Piperidines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P; Tibia; Transcutaneous Electric Nerve Stimulation; Weight-Bearing | 2003 |
Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.
Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; Disease Models, Animal; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptin; Opioid Peptides; Piperidines; Receptors, Opioid; Substance P; Trachea; Vagotomy; Vasodilator Agents | 2004 |
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Atrophy; Autocrine Communication; Binding Sites; Capsaicin; Cell Death; Cell Division; Concanavalin A; Growth Substances; Male; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; T-Lymphocytes; Thymus Gland; Up-Regulation | 2004 |
Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Functional Laterality; Hyperalgesia; Lumbosacral Region; Male; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord Injuries; Statistics, Nonparametric; Substance P; Time Factors | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I.
Topics: Animals; Body Temperature; Bone Diseases, Metabolic; Casts, Surgical; Disease Models, Animal; Edema; Hindlimb; Indoles; Male; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Reflex Sympathetic Dystrophy; Signal Transduction; Substance P; Tibial Fractures | 2004 |
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission | 2004 |
Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent.
Topics: Animals; Antineoplastic Agents; Bronchoalveolar Lavage Fluid; Female; Histamine; Humans; Hypersensitivity; Indoles; Male; Neurokinin-1 Receptor Antagonists; Ovarian Neoplasms; Paclitaxel; Piperidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Retrospective Studies; Substance P | 2004 |
Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Glioma; Humans; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P | 2004 |
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Indoles; Injections, Intraventricular; Male; Maze Learning; Microinjections; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P; Thiorphan; Time Factors | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
Absence of NK1 receptors in human blood lymphocytes and granulocytes.
Topics: Adult; Animals; Antidepressive Agents; Cerebral Cortex; Female; Granulocytes; Humans; Lymphocytes; Male; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Stereoisomerism; Stress, Psychological; Substance P | 2004 |
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine.
Topics: Catalysis; Combinatorial Chemistry Techniques; HIV Protease Inhibitors; Molecular Structure; Neurokinin-1 Receptor Antagonists; Piperidines; Stereoisomerism; Substance P | 2004 |
Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Calcium; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Humans; Inositol Phosphates; Intracellular Space; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin A; Peptides, Cyclic; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Sequence Homology, Amino Acid; Substance P; Transfection; Tritium | 2004 |
Nucleophilic addition to 3-substituted pyridinium salts: expedient syntheses of (-)-L-733,061 and (-)-CP-99,994.
Topics: Molecular Structure; Piperidines; Pyridinium Compounds; Stereoisomerism; Structure-Activity Relationship; Substance P | 2004 |
Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptors.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Cell Line; Coculture Techniques; Fluorescent Antibody Technique; Interleukin-1; Mast Cells; Mice; Mice, Inbred BALB C; Neurites; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Scorpion Venoms; Substance P; Superior Cervical Ganglion | 2004 |
NK-1 antagonist CP99994 inhibits stress-induced mast cell degranulation in rats.
Topics: Animals; Cell Degranulation; Cold Temperature; Dose-Response Relationship, Drug; Food Deprivation; Immobilization; Mast Cells; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin; Stress, Psychological; Substance P | 2004 |
Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Neurokinin-1 Receptor Antagonists; Piperidines; Substance P; Time Factors | 2005 |
Neurokininergic mechanism within the lateral crescent nucleus of the parabrachial complex participates in the heart-rate response to nociception.
Topics: Afferent Pathways; Animals; Brachial Plexus; Decerebrate State; Efferent Pathways; Female; GABA Agonists; GABA-A Receptor Agonists; Heart Rate; Hypertension; Isonicotinic Acids; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Pons; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Sympathetic Nervous System; Tachycardia | 2005 |
Functional interaction between nucleus tractus solitarius NK1 and 5-HT3 receptors in the inhibition of baroreflex in rats.
Topics: Animals; Aorta; Baroreflex; Bradycardia; Electric Stimulation; Escape Reaction; Granisetron; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Solitary Nucleus; Substance P; Tetrazoles | 2005 |
CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.
Topics: Animals; Bradykinin; Calcium; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dose-Response Relationship, Drug; Dronabinol; Enzyme Induction; Enzyme Inhibitors; Ganglia, Spinal; Isoquinolines; Male; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Substance P; Sulfonamides; Time Factors | 2005 |
Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
Topics: Adrenergic Agents; Animals; Benzazepines; Bicuculline; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Oxidopamine; Piperidines; Potassium Chloride; Quinuclidines; Raclopride; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra; Tetrodotoxin; Time Factors | 2005 |
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2005 |
Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Inositol Phosphates; Iodine Radioisotopes; Ligands; Morpholines; Mutation, Missense; Neurokinin A; Phthalic Acids; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Substance P; Tritium | 2005 |
Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.
Topics: Action Potentials; Analgesics; Animals; Antipsychotic Agents; Atropine; Electric Stimulation; Ileum; Indoles; Isoindoles; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurons; Nitroarginine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2005 |
The NK1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line, Tumor; Glioma; Humans; Mitogens; Neuroblastoma; Piperidines; Receptors, Neurokinin-1; Substance P | 2005 |
Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Mitogens; Neurokinin-1 Receptor Antagonists; Piperidines; Retinal Neoplasms; Retinoblastoma; Substance P; Tetrazolium Salts | 2005 |
Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970.
Topics: Animals; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Granisetron; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurons; Peptide Fragments; Phenols; Piperidines; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Sulfonamides | 2005 |
TRPV1 activation results in disruption of the blood-brain barrier in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillaries; Capillary Permeability; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Microspheres; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Starch; Substance P; Tetrazoles; Time Factors; TRPV Cation Channels | 2005 |
Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.
Topics: Amides; Animals; Arachidonic Acids; Bronchi; Bronchoconstriction; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Agonists; Capsaicin; Electric Stimulation; Endocannabinoids; Ethanolamines; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Organ Culture Techniques; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Substance P | 2005 |
Inhibition of substance P activity prevents stress-induced bladder damage.
Topics: Animals; Cell Degranulation; Dose-Response Relationship, Drug; Injections, Intraventricular; Mast Cells; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sodium Chloride; Stress, Physiological; Substance P; Urinary Bladder Diseases; Urothelium | 2006 |
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
Topics: Albumins; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Glycoproteins; Immunohistochemistry; Inflammation; Injections, Intradermal; Iodine Isotopes; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Skin; Substance P; Tachykinins; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.
Topics: Action Potentials; Animals; Coiled Bodies; Dilatation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Mice; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.
Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Catechols; Cations; Cell Line, Tumor; Dose-Response Relationship, Drug; Fatty Alcohols; Guanidine; Guinea Pigs; Humans; Ileum; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Isotonic Contraction; Male; Mice; Organic Cation Transport Proteins; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Sodium Channels; Substance P; Tritium; Tropisetron; Veratridine; Zingiber officinale | 2006 |
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin | 2006 |
Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins | 2006 |
Upregulation of tachykinin NK-1 and NK-3 receptor binding sites in the spinal cord of spontaneously hypertensive rat: impact on the autonomic control of blood pressure.
Topics: Acetates; Animals; Autonomic Nervous System; Autoradiography; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Indoles; Injections, Spinal; Male; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Spinal Cord; Substance P; Thoracic Vertebrae; Up-Regulation | 2006 |
[3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain.
Topics: Adolescent; Aged, 80 and over; Animals; Aprepitant; Autoradiography; Binding, Competitive; Brain; Female; Gerbillinae; Humans; In Vitro Techniques; Kinetics; Ligands; Male; Middle Aged; Models, Animal; Morpholines; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Substance P; Tetrazoles; Tritium | 2006 |
Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Biological Clocks; Dose-Response Relationship, Drug; Drug Interactions; Flufenamic Acid; In Vitro Techniques; Ketanserin; Mice; Nerve Net; Neurons; Oxygen; Patch-Clamp Techniques; Piperidines; Receptor, Serotonin, 5-HT2A; Respiratory Burst; Respiratory Center; Respiratory Mechanics; Serotonin Antagonists; Substance P; Synaptic Transmission; Time Factors | 2006 |
Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [18F]SPA-RQ.
Topics: Adult; Aging; Brain; Brain Chemistry; Brain Mapping; Dopamine; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Neurokinin-1; Regression Analysis; Sex Characteristics; Substance P; Tetrazoles | 2007 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Mexiletine; Motor Activity; Neuralgia; Nitriles; Pain; Pain Measurement; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers; Stress, Mechanical; Substance P; Veratridine | 2006 |
Differential effects of endothelin on activation of renal mechanosensory nerves: stimulatory in high-sodium diet and inhibitory in low-sodium diet.
Topics: Animals; Antihypertensive Agents; Diet, Sodium-Restricted; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Ganglia, Spinal; Gene Expression Regulation; Hypertension; Kidney; Male; Mechanotransduction, Cellular; Neurons, Afferent; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sodium, Dietary; Substance P | 2006 |
Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor.
Topics: Animals; Animals, Newborn; Astrocytes; Astrocytoma; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Neurokinin-1 Receptor Antagonists; Oligonucleotide Array Sequence Analysis; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Time Factors | 2006 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea.
Topics: Animals; Diaphragm; Electric Stimulation; Male; Microinjections; Phrenic Nerve; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; Respiratory Center; Respiratory Function Tests; Respiratory Mechanics; Substance P; Vagus Nerve | 2006 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Suppression by bepotastine besilate of substance P-induced itch-associated responses through the inhibition of the leukotriene B4 action in mice.
Topics: Administration, Oral; Animals; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Ganglia, Spinal; Histamine H1 Antagonists; Leukotriene B4; Male; Mice; Mice, Inbred ICR; Neurons; Neutrophils; Piperidines; Pruritus; Pyridines; Skin; Substance P | 2006 |
How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Edema; Female; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Pruritus; Quinuclidines; Receptors, Neurokinin-1; Skin; Spider Venoms; Substance P; Vasculitis, Leukocytoclastic, Cutaneous | 2006 |
Substance P receptor mediated maintenance of chronic inflammation in EAE.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Immunosuppression Therapy; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P | 2006 |
NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla.
Topics: Animals; Capsaicin; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; Immunohistochemistry; Iontophoresis; Male; Medulla Oblongata; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2007 |
In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imaging systems.
Topics: Animals; Autoradiography; Brain; Brain Mapping; Fluorine Radioisotopes; Image Processing, Computer-Assisted; In Vitro Techniques; Piperidines; Positron-Emission Tomography; Primates; Receptors, Neurokinin-1; Rodentia; Substance P; Tetrazoles | 2007 |
A role for tachykinins in the regulation of human sperm motility.
Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138.
Topics: Apoptosis; Blotting, Western; Cell Count; Cell Proliferation; Child, Preschool; Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Retinal Neoplasms; Retinoblastoma; Stereoisomerism; Substance P; Tryptophan; Tumor Cells, Cultured | 2007 |
Involvement of chemical mediators in nasal allergic responses of HDC-KO mice.
Topics: Animals; Behavior, Animal; Chlorpheniramine; Histamine H1 Antagonists; Histidine Decarboxylase; Hydantoins; Immunization; Immunoglobulin E; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Seasonal; Sneezing; Substance P | 2007 |
Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
Topics: Animals; Anti-Infective Agents, Local; Clotrimazole; Coronary Vessels; Dequalinium; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperidines; Potassium; Potassium Channel Blockers; Protein Precursors; Quinoxalines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Prostaglandin; Substance P; Swine; Tachykinins; Tetraethylammonium; Vasodilation | 2007 |
Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Male; Mice; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Protein Precursors; Quinuclidines; Rats; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagotomy; Vagus Nerve | 2007 |
NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Laryngeal Neoplasms; Mitosis; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan | 2008 |
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Foot; Gerbillinae; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2007 |
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Arachidonic Acids; Behavior, Animal; Corpus Striatum; Dopamine Agonists; Enkephalins; Gene Expression Regulation; Grooming; Male; Models, Biological; Motor Activity; Movement; Nerve Tissue Proteins; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Substance P | 2008 |
Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons.
Topics: Afferent Pathways; Animals; Male; Nerve Fibers, Unmyelinated; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Presynaptic Terminals; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Nerve; Trigeminal Nuclei | 2008 |
Neurokinin-1 receptors modulate the excitability of expiratory neurons in the ventral respiratory group.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Exhalation; Homocysteine; Male; Models, Biological; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiratory Center; Substance P | 2008 |
Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor.
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Binding Sites; Brain; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Ferrets; Gerbillinae; Humans; Kinetics; Male; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P; Transfection; Vomiting | 2008 |
Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Benzamides; Biphenyl Compounds; Blood Pressure; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Catechin; Intercellular Adhesion Molecule-1; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oxidative Stress; Petroleum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Distress Syndrome; Smoke; Smoke Inhalation Injury; Substance P; Up-Regulation | 2008 |
Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair.
Topics: Animals; Apoptosis; Bronchi; Immunohistochemistry; Inhalation; Male; Neurokinin-1 Receptor Antagonists; Ozone; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiratory Mucosa; Substance P; Trachea | 2008 |
Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.
Topics: Animals; Bronchoalveolar Lavage; Capsaicin; Cell Survival; Female; Gene Expression Regulation, Enzymologic; Lung; Macrophages, Alveolar; Matrix Metalloproteinase 12; Mice; Piperidines; Pulmonary Emphysema; Receptors, Neurokinin-1; RNA, Messenger; Smoking; Substance P; Up-Regulation | 2008 |
Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.
Topics: Animals; Antiemetics; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enteric Nervous System; Neurokinin-1 Receptor Antagonists; Oncogene Proteins v-fos; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Shrews; Stereotyped Behavior; Substance P; Time Factors; Tissue Distribution; Vomiting | 2008 |
Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice.
Topics: Animals; Capsaicin; Cetirizine; Disease Models, Animal; Female; Histamine; Histamine Agonists; Histamine H1 Antagonists, Non-Sedating; Imidazoles; Mice; Mice, Inbred BALB C; Ovalbumin; Piperidines; Pyrrolidines; Receptors, Histamine H3; Rhinitis, Allergic, Perennial; Substance P; Thiourea | 2008 |
Neurokinin receptor modulation of respiratory activity in the rabbit.
Topics: Animals; Exhalation; Inhalation; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phrenic Nerve; Piperidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Vagotomy | 2008 |
Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
Topics: Acute Disease; Amylases; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Lung; Male; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Piperidines; Pneumonia; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: a comparison to other agents.
Topics: Animals; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fear; Female; Fluorobenzenes; Gerbillinae; Interpersonal Relations; Locomotion; Male; Mice; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Binding; Psychomotor Performance; Rats; Rats, Wistar; Substance P; Vocalization, Animal | 2008 |
Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429.
Topics: Amygdala; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Feedback; Ligands; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Stress, Psychological; Substance P; Synapses; Synaptic Transmission | 2008 |
Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.
Topics: Analgesics, Non-Narcotic; Animals; Area Postrema; Brain Stem; Cisplatin; Dronabinol; Drug Therapy, Combination; Female; Immunohistochemistry; Injections, Intraperitoneal; Microscopy, Confocal; Neurons; Oncogene Proteins v-fos; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Serotonin; Shrews; Solitary Nucleus; Substance P; Time Factors; Vomiting | 2009 |
The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Mitogens; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Stomach Neoplasms; Substance P | 2008 |
Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Female; Injections, Spinal; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex; Spinal Cord Ischemia; Spinal Nerves; Substance P; Time Factors; Urinary Bladder; Urination | 2008 |
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
Topics: Animals; Carrageenan; Data Interpretation, Statistical; Extravasation of Diagnostic and Therapeutic Materials; Inflammation; Interleukin-1beta; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Pain; Peroxidase; Piperidines; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serum Albumin, Radio-Iodinated; Substance P; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha | 2009 |
Substance P in stress and anxiety: NK-1 receptor antagonism interacts with key brain areas of the stress circuitry.
Topics: Animals; Anxiety; Brain; Genes, fos; Male; Maze Learning; Models, Biological; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Stress, Physiological; Substance P | 2008 |
Galanin modulates vagally induced contractions in the mouse oesophagus.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Electric Stimulation; Enzyme Inhibitors; Esophagus; Female; Galanin; Indoles; Male; Mice; Muscle Contraction; NG-Nitroarginine Methyl Ester; Phenanthrolines; Piperidines; Polyunsaturated Alkamides; Receptors, Galanin; Sensory System Agents; Substance P; Vagus Nerve | 2009 |
Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats.
Topics: Animals; Colitis; Dinitrofluorobenzene; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Substrate Specificity; Tumor Necrosis Factor-alpha | 2009 |
Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin.
Topics: Afferent Pathways; Animals; Antihypertensive Agents; Blood Pressure; Dinoprostone; Efferent Pathways; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Ganglia, Spinal; Gene Expression; Kidney; Kidney Pelvis; Male; Models, Biological; Myocytes, Smooth Muscle; Neuroglia; Norepinephrine; Oligopeptides; Peptides, Cyclic; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Reflex; Sodium, Dietary; Substance P | 2009 |
Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor network.
Topics: Action Potentials; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Lampreys; Locomotion; Models, Biological; Morpholines; N-Methylaspartate; Naphthalenes; Nerve Net; Neural Pathways; Neurotransmitter Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Spinal Cord; Substance P; Tachykinins | 2009 |
Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.
Topics: Analgesics; Animals; Behavior, Animal; Butadienes; Central Nervous System Stimulants; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Nitric Oxide; Nitriles; Nociceptors; Pain; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Spinal Cord; Stereoisomerism; Substance P | 2009 |
Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Colon; Dose-Response Relationship, Drug; Endocannabinoids; Guinea Pigs; In Vitro Techniques; Indoles; Motor Neurons; Neural Inhibition; Peristalsis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Sensory Receptor Cells; Substance P; Vasoactive Intestinal Peptide | 2009 |
Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Pain, Postoperative; Piperidines; Protein Precursors; Signal Transduction; Substance P; Tachykinins; Time Factors | 2009 |
The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome.
Topics: Animals; Antirheumatic Agents; Caspase 1; Caspases, Initiator; Complex Regional Pain Syndromes; Cytokines; Enzyme-Linked Immunosorbent Assay; Fractures, Bone; Gene Expression Regulation; Indoles; Interleukin 1 Receptor Antagonist Protein; Keratinocytes; Keratins; Male; Nerve Growth Factor; Nerve Tissue Proteins; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P; Time Factors | 2009 |
Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance.
Topics: Animals; Antihypertensive Agents; Cyclic AMP-Dependent Protein Kinases; Diuresis; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Renal; Isoquinolines; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Natriuresis; Neurons, Afferent; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Endothelin A; Receptor, Endothelin B; Substance P; Sulfonamides; TRPV Cation Channels | 2009 |
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.
Topics: Animals; Capsaicin; Central Nervous System Agents; Freund's Adjuvant; Hot Temperature; Male; Medulla Oblongata; Mustard Plant; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 2010 |
Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice.
Topics: Alopecia; Animals; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Precursors; Radiation Injuries, Experimental; Receptors, Neurokinin-1; Substance P; Tachykinins | 2010 |
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Topics: Animals; Capsaicin; Electric Stimulation; GABA-B Receptor Antagonists; Injections, Spinal; Male; Morpholines; Neurons; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; Substance P; TRPV Cation Channels | 2010 |
IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.
Topics: Calcium; Cytosol; Humans; Immunohistochemistry; Interleukin-33; Interleukins; Mast Cells; Neurokinin-1 Receptor Antagonists; Piperidines; Psoriasis; RNA, Messenger; Skin; Substance P; Vascular Endothelial Growth Factor A | 2010 |
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fentanyl; Freund's Adjuvant; Histamine Agonists; Hyperalgesia; Inflammation; Male; Methylhistamines; Mice; Naloxone; Pain; Piperidines; Receptors, Histamine H3; Skin; Substance P | 2010 |
Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Lumbar Vertebrae; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Pain; Pain Measurement; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Spinal Nerves; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2010 |
PAR(2) and temporomandibular joint inflammation in the rat.
Topics: Animals; Arthritis; Arthropathy, Neurogenic; Immunity, Innate; Injections, Intra-Articular; Male; Nerve Fibers; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Neurons; Neutrophil Infiltration; Neutrophils; Oligopeptides; Pain Measurement; Piperidines; Plasma; Quinuclidines; Rats; Rats, Wistar; Receptor, PAR-2; Sensory Receptor Cells; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Ganglion; Trypsin; Ubiquitin Thiolesterase | 2010 |
Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung.
Topics: Animals; Bronchoconstriction; Bronchoconstrictor Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Lung; Male; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P | 2010 |
The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines.
Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Substance P; Tryptophan | 2012 |
[The effect of central histamine H3 receptor on breathing activity of asthmatic guinea pigs].
Topics: Animals; Asthma; Brain; Guinea Pigs; Histamine Agonists; Histamine H3 Antagonists; Lateral Ventricles; Male; Methylhistamines; Muscle Contraction; Piperidines; Receptors, Histamine H3; Substance P; Trachea | 2006 |
NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig.
Topics: Action Potentials; Animals; Antipsychotic Agents; Dopamine; Dopamine Agonists; Electrophysiology; Guinea Pigs; Male; Mesencephalon; Neurons; Organ Culture Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Species Specificity; Substance P | 2011 |
Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure.
Topics: Animals; Brain Stem; Female; Macaca mulatta; Maternal Exposure; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Nicotiana; Patch-Clamp Techniques; Piperidines; Pregnancy; Quinuclidines; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Tobacco Smoke Pollution | 2011 |
Targeting of substance P induces cancer cell death and decreases the steady state of EGFR and Her2.
Topics: Antibodies; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Lapatinib; Ligands; Male; Neoplasms; Neurokinin-1 Receptor Antagonists; Piperidines; Prostatic Neoplasms; Quinazolines; Receptor, ErbB-2; Receptors, Neurokinin-1; Signal Transduction; Substance P; Trastuzumab | 2012 |
Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva).
Topics: Analysis of Variance; Animals; Antiemetics; Dose-Response Relationship, Drug; Drug Synergism; Female; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Shrews; Substance P; Tropisetron; Vomiting | 2011 |
Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Reinforcement, Psychology; Reward; Substance P | 2012 |
Increased neurokinin-1 receptor availability in temporal lobe epilepsy: a positron emission tomography study using [(11)C]GR205171.
Topics: Adult; Carbon Radioisotopes; Epilepsy, Temporal Lobe; Female; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Positron-Emission Tomography; Receptors, Neurokinin-1; Severity of Illness Index; Substance P; Temporal Lobe; Tetrazoles; Young Adult | 2011 |
Influence of influenza A infection on capsaicin-induced responses in murine airways.
Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Influenza A virus; Isoproterenol; Leukocytes; Male; Mice; Mice, Inbred BALB C; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Orthomyxoviridae Infections; Piperidines; Prostaglandin Antagonists; Respiratory Mucosa; Specific Pathogen-Free Organisms; Substance P; Trachea; TRPV Cation Channels; Xanthones | 2012 |
Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Hyperalgesia; Infusions, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Nociception; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2012 |
Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome.
Topics: Animals; Complex Regional Pain Syndromes; Disease Models, Animal; Indoles; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Nociception; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tibial Fractures | 2012 |
Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep.
Topics: Animals; Benzamides; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Sheep; Somatostatin; Substance P | 2012 |
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cells; Dopaminergic Neurons; Inflammation; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Substance P; Substantia Nigra; Tryptophan | 2012 |
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
Topics: Animals; Behavior, Animal; Benzamides; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptor Cross-Talk; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Substance P | 2012 |
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.
Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan | 2013 |
Role of substance P in renal injury during DOCA-salt hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Hydroxyproline; Hypertension; Isoindoles; Kidney; Male; Mice; Mice, Inbred C57BL; Piperidines; Receptors, Neurokinin-1; Substance P; Telemetry; Time Factors | 2012 |
The substance P/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists.
Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tryptophan; Tumor Cells, Cultured | 2012 |
Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arcuate Nucleus of Hypothalamus; Dynorphins; Green Fluorescent Proteins; Kisspeptins; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurokinin B; Neurons; Oligopeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Receptors, Tachykinin; Substance P | 2013 |
Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1/2 and JNK MAPK transcription pathways.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Proliferation; Cells, Cultured; Cytokines; Indoles; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin Gene-Related Peptide; Substance P; Transcription, Genetic; Transcriptional Activation | 2013 |
Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antirheumatic Agents; Bombesin; Chloroquine; Drug Combinations; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gastrin-Releasing Peptide; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pruritus; Substance P; Vesicular Glutamate Transport Protein 2 | 2014 |
Abnormal response to the anorexic effect of GHS-R inhibitors and exenatide in male Snord116 deletion mouse model for Prader-Willi syndrome.
Topics: Analysis of Variance; Animals; Anorexia; Disease Models, Animal; Eating; Exenatide; Fasting; Ghrelin; Humans; Hyperphagia; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Peptides; Piperidines; Prader-Willi Syndrome; Quinazolinones; Receptors, Ghrelin; RNA, Small Nucleolar; Substance P; Venoms | 2014 |
Neurokinin-1 receptor antagonist orvepitant is an effective inhibitor of itch-associated response in a Mongolian gerbil model of scratching behaviour.
Topics: Administration, Oral; Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pruritus; Substance P | 2014 |
Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Binding Sites; Carbamates; Central Nervous System Agents; Dopaminergic Neurons; Female; Gerbillinae; Guinea Pigs; HEK293 Cells; Humans; Locomotion; Male; Models, Molecular; Molecular Sequence Data; Mutation; Neurotransmitter Agents; Pars Compacta; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tissue Culture Techniques | 2014 |
The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer.
Topics: Antineoplastic Agents; Aprepitant; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MCF-7 Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan | 2014 |
Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.
Topics: Animals; Anthracenes; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; GABAergic Neurons; Glutamate Decarboxylase; Imidazoles; In Vitro Techniques; Isoindoles; Mice; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase Type III; Patch-Clamp Techniques; Piperidines; Quinolines; Quinuclidines; Signal Transduction; Substance P; Type C Phospholipases; Visual Cortex | 2016 |
A two-step strategy to enhance activity of low potency peptides.
Topics: Glycine; HEK293 Cells; Humans; Ligands; Peptides; Piperidines; Plasmids; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Recombinant Proteins; Signal Transduction; Substance P; Tetragastrin | 2014 |
Elevated SP/NK-1R in esophageal carcinoma promotes esophageal carcinoma cell proliferation and migration.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Calcium Channel Blockers; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Esophageal Neoplasms; Female; Humans; Imidazoles; Lymphatic Metastasis; Male; Mice, Nude; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Xenograft Model Antitumor Assays | 2015 |
Neurokinin-1 activation affects EGFR related signal transduction in triple negative breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cetuximab; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Middle Aged; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; RNA Interference; RNA, Small Interfering; Signal Transduction; Substance P; Triple Negative Breast Neoplasms | 2015 |
Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrodes; Electrophysiology; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Male; Microcirculation; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Skin; Substance P; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation.
Topics: Animals; Central Amygdaloid Nucleus; Fluorescent Antibody Technique; GABAergic Neurons; Gene Knock-In Techniques; Glutamate Decarboxylase; Green Fluorescent Proteins; Male; Membrane Potentials; Mice, Inbred C57BL; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Patch-Clamp Techniques; Piperidines; Potassium; Protein Kinase C-delta; Receptors, Neurokinin-1; Substance P; Tissue Culture Techniques | 2015 |
Overlapping expression of serotonin transporters and neurokinin-1 receptors in posttraumatic stress disorder: a multi-tracer PET study.
Topics: Adult; Amygdala; Aniline Compounds; Anxiety Disorders; Brain; Case-Control Studies; Cerebral Cortex; Female; Humans; Male; Piperidines; Positron-Emission Tomography; Receptors, Neurokinin-1; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stress Disorders, Post-Traumatic; Substance P; Sulfides; Tetrazoles; Transcriptome | 2016 |
Acute versus chronic phase mechanisms in a rat model of CRPS.
Topics: Animals; Antibodies; Antirheumatic Agents; Body Temperature; Complex Regional Pain Syndromes; Cytokines; Disease Models, Animal; Hindlimb; Indoles; Interleukin 1 Receptor Antagonist Protein; Male; Nerve Growth Factor; Neurokinin-1 Receptor Antagonists; Nociception; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sciatic Nerve; Substance P; Tibial Fractures; Time Factors | 2016 |
Evidence for involvement of NK₃ receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.
Topics: Animals; Anxiety; Male; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 2016 |
Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration.
Topics: Animals; Benzoxazoles; Disease Models, Animal; Dopamine; Enteric Nervous System; Eosinophils; Gastrointestinal Diseases; Gastrointestinal Motility; Glial Fibrillary Acidic Protein; Indoles; Male; Mast Cells; Neurodegenerative Diseases; Oxidopamine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Sympatholytics; Tyrosine 3-Monooxygenase | 2016 |
Neurokinin-1 receptor is a novel positive regulator of Wnt/ β-catenin signaling in melanogenesis.
Topics: Animals; beta Catenin; Cells, Cultured; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Humans; Intercellular Signaling Peptides and Proteins; Melanins; Melanocytes; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Phosphorylation; Piperidines; Receptors, Neurokinin-1; Skin; Skin Pigmentation; Substance P; Time Factors; Wnt Signaling Pathway | 2016 |
Ketamine-xylazine anaesthesia and orofacial administration of substance P: A lethal combination in rats.
Topics: Anesthesia; Animals; Edema; Isoflurane; Ketamine; Male; Models, Animal; Piperidines; Quinuclidines; Rats, Wistar; Substance P; Xylazine | 2017 |
SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors.
Topics: Biphenyl Compounds; Cell Line, Tumor; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Luteolin; MAP Kinase Signaling System; Mast Cells; NF-kappa B; Piperidines; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2017 |
Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor.
Topics: Animals; Dopamine; Dopaminergic Neurons; Dynorphins; Ginsenosides; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Reactive Oxygen Species; Receptors, Neurokinin-1; Receptors, Opioid, kappa; Substance P; Up-Regulation | 2018 |
Tachykinin NK1 receptor antagonist L-733,060 and substance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries, Traumatic; Gene Expression Regulation; Gene Knockout Techniques; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Motor Activity; Neurokinin-1 Receptor Antagonists; Neuroprotection; Oxidative Stress; Piperidines; Receptors, Neurokinin-1; Spatial Memory; Substance P | 2019 |
High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs.
Topics: Action Potentials; Animals; Aprepitant; Calcium Signaling; Cholinergic Neurons; Dopaminergic Neurons; Excitatory Postsynaptic Potentials; Interneurons; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Motivation; Neurokinin-1 Receptor Antagonists; Nucleus Accumbens; Photic Stimulation; Piperidines; Receptor, Muscarinic M1; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Neurokinin-1; Substance P | 2019 |
Effect of neurokinin-1-receptor blockage on fracture healing in rats.
Topics: Animals; Collagen Type I; Collagen Type II; Disease Models, Animal; Femoral Fractures; Fracture Healing; Gene Expression Regulation, Neoplastic; Male; Neurokinin-1 Receptor Antagonists; Osteocalcin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome | 2019 |
Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides.
Topics: Adolescent; Adult; Alternative Splicing; Animals; Benzamides; Biopsy; Bone Marrow; Bone Marrow Transplantation; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; HEK293 Cells; Hematopoiesis; Hematopoietic Stem Cells; HMGB1 Protein; Humans; Mice; Neuroimmunomodulation; Neurokinin A; Oligonucleotide Array Sequence Analysis; Piperidines; Primary Cell Culture; Substance P; Tachykinins; Transplantation Chimera; Young Adult | 2020 |
Role of the Neurokinin-1 Receptor in the Promotion of Corneal Epithelial Wound Healing by the Peptides FGLM-NH2 and SSSR in Neurotrophic Keratopathy.
Topics: Animals; Corneal Injuries; Epithelium, Corneal; Insulin-Like Growth Factor I; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; Signal Transduction; Substance P; Wound Healing | 2020 |
Blocking NK1 receptors disrupts the sequential and temporal organization of chain grooming in rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Grooming; Markov Chains; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Substance P | 2021 |
Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats.
Topics: Aging; Animals; Disease Models, Animal; Flavanones; Hip Fractures; Indoles; Male; Neurokinin-1 Receptor Antagonists; Nociceptive Pain; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance P | 2022 |
The NK1 antagonist L-733,060 facilitates sequence learning.
Topics: Animals; Conditioning, Operant; Learning; Piperidines; Rats; Receptors, Neurokinin-1; Reinforcement, Psychology; Reward; Substance P | 2023 |