substance p has been researched along with neurokinin a in 1119 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 215 (19.21) | 18.7374 |
| 1990's | 658 (58.80) | 18.2507 |
| 2000's | 194 (17.34) | 29.6817 |
| 2010's | 45 (4.02) | 24.3611 |
| 2020's | 7 (0.63) | 2.80 |
| Authors | Studies |
|---|---|
| Vigna, SR | 1 |
| Buck, SH; Harbeson, SL; Le, TB; Shatzer, SA | 1 |
| Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; McElroy, AB; Porter, B; Ross, BC; Stephens-Smith, M; Ward, P | 1 |
| Cuello, AC; Elliott, P; Escher, E; Neugebauer, W | 1 |
| Breliere, JC; Emonds-Alt, X; Golliot, F; Le Fur, G; Pointeau, P | 1 |
| Bryce, D; Chalabi, PM; Desai, MC; Guarino, KJ; Heym, J; McLean, S; Pratt, K; Rosen, T; Seeger, TF; Windels, JH | 1 |
| Brawner, ME; Elshourbagy, NA; Foley, JJ; Giardina, GA; Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Potts, W; Sarau, HM; Schmidt, DB; Webb, EF | 1 |
| Cascieri, MA; Harrison, T; Korsgaard, MP; Sadowski, S; Seabrook, GR; Swain, CJ | 1 |
| Chassaing, G; Clodic, G; Karoyan, P; Lavielle, S; Sagan, S | 1 |
| Allen, J; Gembitsky, DS; Lovas, S; Murnin, M; Murphy, RF; Otvös, FL | 1 |
| Ames, RS; Brawner, ME; Buckley, PT; Elshourbagy, NA; Feild, JA; Foley, JJ; Giardina, GA; Hay, DW; Luttmann, MA; Nuthulaganti, P; Sarau, HM; Schmidt, DB | 1 |
| Bellucci, F; Carini, F; Catalani, C; Cucchi, P; Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Patacchini, R; Quartara, L; Ricci, R; Tramontana, M | 1 |
| Krause, JE; Sivam, SP | 1 |
| Ebii, K; Fujiwara, M; Fukunaga, R; Ninomiya, H; Taniguchi, T; Yamamoto, M | 1 |
| North, RA; Shen, KZ | 1 |
| Cooke, HJ; Reddix, RA | 1 |
| Fong, TM; Huang, RR; Strader, CD; Yu, H | 1 |
| Czarnobilski, K; Gustaw, P; Jaworek, J; Konturek, SJ; Pawlik, WW; Sendur, R; Yanaihara, N | 1 |
| Irvine, GB; Johnston, CF; Leung, PS; Shaw, C | 1 |
| Fujii, T; Matsuda, A; Miyake, H; Morimoto, H; Yamashita, M | 1 |
| Beaujouan, JC; Brunissen, A; Carruette, A; Chassaing, G; Garret, C; Glowinski, J; Lavielle, S; Petitet, F; Saffroy, M; Torrens, Y | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Tremblay, L | 1 |
| Fong, TM; Huang, RR; Strader, CD | 1 |
| Fong, TM; Strader, CD; Yu, H | 1 |
| Zilov, VG | 1 |
| Brunelleschi, S; Ceni, E; Fantozzi, R; Giotti, A; Parenti, A | 1 |
| Chrétien, L; Guillemette, G; Regoli, D; Tousignant, C | 1 |
| Mathé, AA; Srinivasan, GR; Stenfors, C; Theodorsson, E | 1 |
| Beesley, PW; Bollner, T; Thorndyke, MC | 1 |
| Flowers, JM; Hall, JM; Morton, IK | 1 |
| Drazen, JM; Martins, MA; Shore, SA | 5 |
| Conlon, JM; O'Harte, F; Wang, Y | 1 |
| Andersson, R; Edvinsson, L; Gullberg, U; Richter, J | 1 |
| Törnwall, J; Uusitalo, H; Virta, E | 1 |
| Hosoki, R; Kurihara, T; Otsuka, M; Saito, K; Seno, N; Suzuki, H; Yanagisawa, M; Yoshioka, K | 1 |
| Busija, DW; Chen, J | 1 |
| Chang, FY; Lee, SD; Wang, PS; Yeh, GH | 2 |
| Barbanti, G; Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R; Santicioli, P; Theodorsson, E; Turini, D | 1 |
| Atkinson, B; Foreman, JC; Hayes, N; Lee, TH; Morris, RW; Smith, CH | 1 |
| Burcher, E; Geraghty, DP; Mussap, CJ | 1 |
| Laurell, H; Peterson, PA; Pohl, JS; Provvedini, DM; Sundelin, JB; Wahlestedt, CR | 1 |
| Kalra, SP; Sahu, A | 1 |
| Hyman, PE; Kimura, S; McRoberts, JA; Snape, WJ; Tomomasa, T; Yuan, QX | 1 |
| Mio, M; Tasaka, K; Yoshida, T | 1 |
| Basile, S; Cheung, NS; Livett, BG | 1 |
| Broad, RM; Brodin, E; Cook, MA; McDonald, TJ | 1 |
| Broomfield, CA; Krumins, SA | 1 |
| Homma, I; Inoue, K; Sakai, Y | 1 |
| Haxhiu, MA; Haxhiu-Poskurica, B; Kumar, GK; Martin, RJ; Miller, MJ | 1 |
| Appell, KC; Fragale, BJ; Loscig, J; Singh, S; Tomczuk, BE | 1 |
| Wiesenfeld-Hallin, Z; Xu, XJ | 2 |
| Cheung, AH; Fong, TM; Huang, RR; Mazina, KE; Strader, CD | 1 |
| Akhundova, A; Fahrenholz, F; Gorbulev, V; Luzius, H | 1 |
| Brown, DR; Chandan, R; Larson, AA; Murray, CR; Parsons, AM; Seybold, VS; Soldani, G; Vogt, J | 1 |
| Conlon, JM; Jensen, J | 1 |
| Buckner, CK; DeHaas, CJ; Krell, RD; Kusner, EJ; Lengel, DJ; Marks, RL | 1 |
| Holst, JJ; Rasmussen, TN; Schmidt, P | 1 |
| Fujii, T; Kiyotoh, S; Maeda, Y; Morimoto, H; Murai, M; Nishikawa, M; Yamaoka, M | 1 |
| Bonici, B; Cuiné, F; Faucher, DC; Garret, C; Laduron, PM; Le Prado, N; Moussaoui, SM | 1 |
| Corcoran, BM; Haigh, AL | 1 |
| Edvinsson, L; Jansen, I; Nilsson, L | 1 |
| Ferrell, WR; Lam, FY | 2 |
| Clark, D; Elliott, PJ; Hagan, RM; Overton, P | 1 |
| Bartho, L; Maggi, CA; Patacchini, R; Santicioli, P | 1 |
| Bowery, B; Hill, RG; Main, M; Seabrook, GR; Wood, N | 1 |
| Bonavera, JJ; Kalra, PS; Kalra, SP; Sahu, A | 1 |
| Hrabec, E; Hrabec, Z; Płucienniczak, A | 1 |
| Ertl, RF; Koyama, S; O'Neill, D; Rennard, SI; Robbins, RA; Rubinstein, I; Von Essen, SG | 1 |
| Randic, M; Rusin, KI; Ryu, PD | 1 |
| Baraniuk, JN; Hausfeld, JH; Kaliner, MA; Lundgren, JD; Mérida, M; Mullol, J; Rieves, RD; Shelhamer, JH | 1 |
| Albus, K; Chao, HH; Hicks, TP | 1 |
| Elliott, PJ; Mason, GS | 1 |
| Kanazawa, I; Konishi, S; Ogawa, T; Song, SY | 2 |
| Chen, JQ; Imai, Y; Inoki, R; Yonehara, N | 1 |
| Akazawa, C; Nakanishi, S; Ohkubo, H; Yokota, Y | 1 |
| Fujii, T; Maeda, Y; Morimoto, H; Murai, M | 1 |
| Katsumata, K; Kisara, K; Manome, Y; Sakurada, S; Sakurada, T; Tan-No, K; Uchiumi, H | 1 |
| Desmazes, N; Dusser, DJ; Lacroix, H; Lockhart, A | 1 |
| Eglezos, A; Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R; Quartara, L | 1 |
| Alouan, LA; Armour, CL; Badgery-Parker, T; Black, JL; Burcher, E; Diment, LM; Johnson, PR | 1 |
| Dalsgaard, CJ; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Culman, J; Itoi, K; Jost, N; Lebrun, C; Stauss, B; Tschöpe, C; Unger, T | 1 |
| Drazen, JM; Gerard, C; Gerard, NP; Martins, MA; Shore, SA | 1 |
| Koelbel, CB; Leduc, L; Mayer, EA; Snape, WJ; Vandeventer, G | 1 |
| Bartfai, T; Iverfeldt, K; Solti, M | 1 |
| Brunner, SL; Cook, JA; Tanaka, DT | 1 |
| Helke, CJ; Niederer, AJ | 1 |
| Lindstrand, K; Luts, A; Montavon, P; Sundler, F | 1 |
| Advenier, C; Dion, S; Drapeau, G; Naline, E; Nantel, F; Regoli, D; Rouissi, N | 1 |
| Moritoki, H; Takase, H; Tanioka, A | 1 |
| Cecconi, R; Geppetti, P; Maggi, CA; Meini, S; Nardi, M; Patacchini, R; Romani, A; Tramontana, M | 1 |
| Barbanti, G; Giachetti, A; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P; Turini, D | 1 |
| Karlsson, JA; Kröll, F; Lundberg, JM; Persson, CG | 1 |
| Iwamoto, I; Kimura, A; Tanaka, M; Tomioka, H; Yoshida, S | 2 |
| de Caro, G; Gentili, L; Massi, M; Perfumi, M; Schulkin, J | 1 |
| Horii, S; Kanemura, T; Takeyama, K; Takizawa, T; Tamaoki, J | 1 |
| Ek, L; Theodorsson, E | 1 |
| Kangrga, I; Randic, M | 1 |
| Beurling-Harbury, C; Erdös, EG; Jackman, HL; Li, XY; Skidgel, RA; Tamei, H; Tan, FL | 1 |
| Brown, JR; Ewan, GB; Hagan, RM; Ireland, SJ; Jordan, CC; Ward, P | 1 |
| Bleicher, S; Freyer-Barski, A; Hahn, HL; Hümmer, B | 1 |
| Dolara, P; Maggi, CA; Morbidelli, L; Pacini, M; Ziche, M | 1 |
| Carter, MS; Krause, JE | 1 |
| Kimura, S | 1 |
| Krause, JE; Smart, BM; Takeda, J; Takeda, Y | 1 |
| Allen, JM; Guthrie, DJ; Irvine, GB; Murphy, RF; Shanab, AA; Walker, B | 1 |
| Baroldi, P; Maggi, CA; Meli, A; Patacchini, R; Theodorsson, E | 1 |
| Jin, JG; Nakayama, S; Takaki, M | 1 |
| Kondo, M; Takizawa, T; Tamaoki, J | 1 |
| Dion, S; Drapeau, G; Nantel, F; Regoli, D; Rhaleb, NE; Rouissi, N | 2 |
| Brunelleschi, S; Fantozzi, R; Giotti, A; Ledda, F; Maggi, CA; Vanni, L | 1 |
| Bladon, CM; El-Yassir, N; Fleetwood-Walker, SM; Hope, PJ; Mitchell, R; Molony, V | 1 |
| Fujimori, K; Inoue, K; Nakazawa, K; Takanaka, A | 1 |
| Otsuka, M; Yanagisawa, M | 1 |
| Couture, R; Jacques, L | 1 |
| Barnes, PJ; Giembycz, MA; Kroegel, C | 1 |
| Ando, K; Arai, S; Kawamura, K | 1 |
| Classen, M; Schepp, W; Schmidtler, J; Schusdziarra, V; Tatge, C | 1 |
| Willard, AL | 1 |
| Herrera-Marschitz, M; Hökfelt, T; Ohlin, M; Reid, MS; Ungerstedt, U; Valentino, KL | 1 |
| Herrera-Marschitz, M; Reid, MS; Ungerstedt, U | 1 |
| Herrera-Marschitz, M; Reid, MS; Terenius, L; Ungerstedt, U | 1 |
| Guth, PH; Holzer, P | 1 |
| Hellström, PM; Söder, O; Theodorsson, E | 1 |
| Brown, MJ; Price, JS | 1 |
| Gaedicke, G; McGregor, GP; Voigt, K | 1 |
| Geppetti, P; Grassi, J; Maillet, S; Mantellini, P; Renzi, D; Santicioli, P; Surrenti, C; Theodorsson, E | 1 |
| Jew, JY; Maher, JW; Sandler, AD; Schlegel, JF; Schmidt, CD; Weinstock, JV; Williams, TH | 1 |
| Christofi, FL; Cook, MA; McDonald, TJ | 1 |
| Buchanan, KD; Fairweather, I; Halton, DW; Johnston, CF; McKay, DM; Shaw, C | 1 |
| Abraham, WM; Ahmed, A; Baugh, LE; Cortes, A; Farmer, SG; Harbeson, SL; Soler, M | 1 |
| Brunelleschi, S; Fantozzi, R; Giotti, A; Tarli, S | 1 |
| Herrera-Marschitz, M; Hökfelt, T; Lindefors, N; Persson, H; Reid, MS; Ungerstedt, U | 1 |
| Dam, TV; Martinelli, B; Quirion, R | 1 |
| Brunelleschi, S; Ceni, E; Fantozzi, R; Giotti, A | 1 |
| Brene, S; Ericsson, A; Franchimont, P; Geenen, V; Legros, JJ; Persson, H; Robert, F; Vrindts-Gevaert, Y | 1 |
| Prabhakar, NR; Runold, M | 1 |
| Hyman, PE; Snape, WJ; Yagi, H | 1 |
| Ingenito, EP; Ingram, RH; Martins, MA; Pliss, LB | 1 |
| Baraniuk, JN; Goff, J; Kaliner, MA; Lundgren, JD; Merida, M; Mullol, J; Okayama, M; Shelhamer, JH | 1 |
| Andrews, PV; Boyd, RL; Eglezos, A; Helme, RD | 1 |
| Cherniack, NS; Haxhiu, MA; van Lunteren, E | 1 |
| Shinkai, M; Takayanagi, I | 1 |
| Furness, JB; Messenger, JP | 1 |
| Ball, DI; Coleman, RA; Sheldrick, RL | 1 |
| Chowdrey, HS; Jessop, DS; Lightman, SL | 1 |
| Ferner, RE; Kamali, F; Rawlins, MD | 1 |
| Giachetti, A; Maggi, CA; Meli, A; Patacchini, R | 1 |
| Hall, JM; Morton, IK | 2 |
| Besser, GM; Faria, M; Grossman, AB; Navarra, P; Tsagarakis, S | 1 |
| Brackmann, B; Chiwakata, C; Davidoff, M; Hunt, N; Ivell, R; Schulze, W | 1 |
| Bayliss, DA; Czyzyk-Krzeska, MF; Millhorn, DE; Seroogy, KB | 1 |
| Alafaci, C; Edvinsson, L; Jansen, I; Uddman, R | 1 |
| Munekata, E | 1 |
| Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yamada, T | 1 |
| Hagio, T; Kamiya, H; Nagashima, A; Nakayama, Y; Takano, Y; Tateishi, K | 1 |
| Ballati, L; Giachetti, A; Giuliani, S; Lecci, A; Maggi, CA; Manzini, S; Patacchini, R; Quartara, L; Renzetti, AR; Rovero, P | 1 |
| Constantine, JW; Lebel, WS; Woody, HA | 2 |
| Lei, SZ; Lipkowski, AW; Wilcox, GL | 1 |
| Alafaci, C; Edvinsson, L; Jansen, I; McCulloch, J; Uddman, R | 1 |
| Fujii, T; Kiyotoh, S; Morimoto, H; Murai, M; Nishikawa, M | 1 |
| Biswas, S; Chowdrey, HS; Jessop, DS; Lightman, SL | 1 |
| Albegger, K; Bernatzky, G; Graf, AH; Hacker, GW; Hauser-Kronberger, CE; Saria, A | 1 |
| Kerdelhue, B; Mitsuhashi, M; Parnet, P; Payan, DG; Turck, CW | 1 |
| Kambam, JR; Kruskal, JB; Naukam, RJ; Parris, WC | 1 |
| Barnes, PJ; Kuo, HP; Rogers, DF; Rohde, JA; Tokuyama, K | 1 |
| Gill, BK; Nakamura-Craig, M | 1 |
| Maggi, CA; Patacchini, R; Rovero, P; Santicioli, P | 1 |
| Armstrong, EP; Buchanan, KD; Eedy, DJ; Johnston, CF; Shaw, C | 1 |
| Bailey, CJ; Conlon, JM; Flatt, PR; McGregor, GP; Swanston-Flatt, SK | 1 |
| Lantz, I; Nyberg, F; Terenius, L | 1 |
| Giuliani, S; Maggi, CA; Patacchini, R; Santicioli, P | 1 |
| Furness, JB; Murphy, R; Pompolo, S; Shuttleworth, CW | 1 |
| Lee, CM; Tung, WL | 1 |
| Hall, JM; Mitchell, D; Morton, IK | 2 |
| Evangelista, S; Geppetti, P; Maggi, CA; Mantellini, P; Renzi, D; Santicioli, P; Surrenti, C | 1 |
| Barnes, J; Frossard, N | 1 |
| Gamse, R; Humpel, C; Javorsky, F; Saria, A | 2 |
| Holzer-Petsche, U | 1 |
| Dam, TV; Quirion, R; Yashpal, K | 1 |
| Maggi, CA; Patacchini, R; Quartara, L; Rovero, P; Santicioli, P | 1 |
| Myers, AC; Undem, BJ | 2 |
| Henry, JL; Salter, MW | 2 |
| Ekblom, A; Hansson, P; Holmlund, A; Lind, J; Lundeberg, T; Theodorsson, E | 1 |
| Boussougou, M; Jukic, D; Laprise, R; Regoli, D; Rouissi, N | 1 |
| Elliott, PJ; Hagan, RM; Mason, GS; Stephens-Smith, M | 1 |
| Beresford, IJ; Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; Ward, P | 1 |
| Maggi, CA; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Karanth, SS; Kuhn, DM; Levene, MM; Polak, JM; Springall, DR | 1 |
| Alving, K; Lundberg, JM; Matran, R | 1 |
| Buckner, CK; Fishleder, RI; Ghanekar, SV; Kays, JS; Krell, RD; Vann, JM; Will, JA | 1 |
| Jonassen, JA; Leeman, SE | 1 |
| Buck, SH; Fanger, BO; van Giersbergen, PL | 1 |
| Burcher, E; Geraghty, DP; McClure-Sharp, JM; Mussap, CJ; Watkins, DJ | 1 |
| Kobayashi, N; Onishi, Y; Otsuka, M; Sakuma, M; Suzuki, H; Yanagisawa, M; Yoshioka, K | 1 |
| Dube, G; Kalra, PS; Kalra, SP; Sahu, A | 1 |
| Brodin, E; Lorens, SA; Paris, JM | 1 |
| Kodner, A; Mayer, EA; Regoli, M; Sachs, G; Sun, XP; Supplisson, S | 1 |
| Nakanishi, S; Ohkubo, H | 1 |
| Bird, GS; Horstman, DA; Hughes, AR; Menniti, FS; Nogimori, K; Obie, J; Oliver, KG; Putney, JW; Sugiya, H; Takemura, H | 1 |
| Drapeau, G; Jukic, D; Regoli, D; Rhaleb, NE; Rouissi, N | 1 |
| Fujita, H; Kawabata, S; Kuraishi, Y; Matsumoto, T; Nakamura, A; Satoh, M | 1 |
| Luk, DE; Nolan, PN; Staszewska-Woolley, J | 1 |
| Kawashima, K; Kobayashi, N; Onishi, Y; Otsuka, M; Sakuma, M; Yanagisawa, M; Yoshioka, K | 1 |
| Brodin, E; Franck, J; Fried, G; Fried, K; Rosén, A; Yamamoto, Y | 1 |
| Appelgren, A; Appelgren, B; Eriksson, S; Kopp, S; Lundeberg, T; Nylander, M; Theodorsson, E | 1 |
| Franco-Cereceda, A | 1 |
| Barbanti, G; Giachetti, A; Giuliani, S; Maggi, CA; Quartara, L; Rovero, P; Turini, D | 1 |
| Claing, A; D'Orléans-Juste, P; Regoli, D; Télémaque, S; Warner, TD | 1 |
| Kayser, H; Schemann, M | 1 |
| Andersson, SE; Le Greves, P | 1 |
| Barr, AJ; Bernal, AL; Nimmo, AJ; Watson, SP | 1 |
| Kanai, Y; Misawa, M | 1 |
| Barnes, PJ; Chung, KF; Elwood, W; Lötvall, JO; Tokuyama, K | 1 |
| Imai, Y | 1 |
| Itotagawa, T | 1 |
| Amerini, S; Filippi, S; Ledda, F; Mantelli, L; Rubino, A | 1 |
| Drapeau, G; Guillemain, I; Imhoff, V; Regoli, D; Rollandy, I; Rossignol, B | 1 |
| Gustafsson, LE; Hedqvist, P; Persson, MG | 1 |
| Kanazawa, I | 1 |
| Aghajanian, GK; Andrade, R; Innis, RB | 1 |
| Chase, TN; Gullner, HG; O'Donohue, TL; Shults, CW; Yajima, H | 1 |
| Dam, TV; Quirion, R | 1 |
| Deutch, AY; Kalivas, PW; Maggio, JE; Mantyh, PW; Roth, RH | 1 |
| Brodin, E; Lindgren, PG; Lundberg, JM; Norheim, I; Oberg, K; Tatemoto, K; Theodorsson-Norheim, E | 1 |
| Hannah, PA; Hunter, JC; Maggio, JE | 1 |
| Giuliani, S; Maggi, CA; Meli, A; Regoli, D; Santicioli, P | 2 |
| Gamse, R; Saria, A | 2 |
| Jones, RS; Olpe, HR | 1 |
| Brodin, E; Dalsgaard, CJ; Haegerstrand, A; Hökfelt, T; Theodorsson-Norheim, E | 1 |
| Amann, R; Holzer-Petsche, U; Lembeck, F; Schimek, E | 1 |
| Bitar, KN; Grider, JR; Makhlouf, GM; Souquet, JC | 2 |
| Holzer, P | 2 |
| Dun, NJ; Ma, RC; Saria, A | 1 |
| Chorev, M; Friedman, ZY; Gilon, C; Laufer, R; Selinger, Z; Wormser, U | 1 |
| Kanazawa, I; Kimura, S; Ogawa, T | 1 |
| Kamiya, H; Takano, Y; Takeda, Y; Yamada, K | 1 |
| Kalivas, PW | 1 |
| Bannon, MJ; Deutch, AY; Goldstein, M; Kalivas, PW; Maggio, JE; Roth, RH; Tam, SY | 1 |
| Barchas, JD; Beck, O; Evans, CJ; Faull, K; Makk, G; Roth, KA; Tatemoto, K | 1 |
| Björklund, H; Dalsgaard, CJ; Hermansson, A; Jonsson, CE | 1 |
| D'Orléans-Juste, P; Dion, S; Drapeau, G; Escher, E; Mizrahi, J; Regoli, D | 2 |
| Brodin, E; Hökfelt, T; Hua, XY; Lundberg, JM; Theodorsson-Norheim, E | 1 |
| Goto, K; Kanazawa, I; Kubo, K; Munekata, E; Osakada, F | 1 |
| Buck, SH; Burcher, E; Lovenberg, W; O'Donohue, TL | 1 |
| Fischer, JA; Gamse, R; Lundberg, JM; Petermann, J; Saria, A; Theodorsson-Norheim, E | 1 |
| Eimerl, J; Ezra, D; Feuerstein, G; Goldstein, RE; Laurindo, FR; Peck, CC | 1 |
| Gamse, R; Lundberg, JM; Saria, A; Theodorsson-Norheim, E | 2 |
| Maggio, JE | 1 |
| Kamiya, HO; Kuromizu, K; Masui, H; Nagashima, A; Takano, Y | 1 |
| Affolter, HU; Bannon, MJ; Bonner, TI; Giraud, P; Lee, JM; Young, A | 1 |
| Brodin, E; Dalsgaard, CJ; Lindefors, N; Rosell, S; Theodorsson-Norheim, E | 1 |
| Bannon, MJ; Eskay, RL; Lee, JM; Maggio, JE; McLean, S; Roth, RH; Zamir, N | 1 |
| Brodin, E; Lindefors, N; Ungerstedt, U | 3 |
| Snyder, SH | 1 |
| Dalsgaard, CJ; Nilsson, AH; Nilsson, J; Sejersen, T | 1 |
| Giuliani, S; Maggi, CA; Manzini, S; Meli, A; Santicioli, P | 1 |
| Asseraf, A; Descours, B; Devillier, P; Marsac, J; Regoli, D; Renoux, M | 1 |
| D'Orléans-Juste, P; Dion, S; Drapeau, G; Regoli, D | 2 |
| Agoston, DV; Cole, T; Conlon, JM; Deacon, CF; Nau, R; Schäfer, G | 1 |
| Cridland, RA; Henry, JL | 1 |
| Bannon, MJ; Deutch, AY; Eskay, RL; Lee, JM; Maggio, JE; Roth, RH; Tam, SY; Zamir, N | 1 |
| Kobayashi, S; Suzuki, R; Yoshino, H | 1 |
| Fujiwara, M; Muramatsu, I; Nakanishi, S; Taniguchi, T; Ueda, N | 1 |
| Jacoby, HI; Lopez, I; Vaught, JL; Wright, D | 1 |
| Brodin, E; Gamse, R; Hua, XY; Lundberg, JM; Saria, A; Theodorsson-Norheim, E | 1 |
| Hua, XY; Lundberg, JM | 1 |
| Agoston, DV; Conlon, JM; Deacon, CF; Nau, R | 1 |
| Burks, TF; Shook, JE | 1 |
| Fujiwara, M; Kanazawa, I; Masuo, Y; Taniguchi, T | 1 |
| Carter, MS; Chirgwin, JM; Hershey, AD; Krause, JE; Xu, ZS | 1 |
| Dolata, J; Lindberg, S; Mercke, U | 1 |
| Holzer-Petsche, U; Lembeck, F; Seitz, H | 1 |
| Arai, H; Emson, PC | 1 |
| Lundberg, JM; Martling, CR; Theodorsson-Norheim, E | 1 |
| Bailey, CJ; Conlon, JM; Deacon, CF; Flatt, PR; Shaw, C | 1 |
| Foreman, JC | 1 |
| Edvinsson, L; Jansen, I | 1 |
| Ekström, J; Månsson, B; Tobin, G | 1 |
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| Ahangari, R; Coveñas, R; Csillik, B; Narváez, JA; Riquelme, R; Samsam, M; Tramu, G; Yajeya, J | 1 |
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| Boyd, ND; Bremer, AA; Leeman, SE; Tansky, MF; Wu, M | 1 |
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| Amin, M; Amin, S; Barbe, MF; Barr, AE; Clark, BD; Elliott, MB | 1 |
| Burcher, E; King, DW; Liu, L; Lubowski, DZ; Morgan, MJ; Shang, F | 1 |
| Andersson, KE; Imamura, T; Ishizuka, O; Kurizaki, Y; Nakayama, T; Nishizawa, O; Ogawa, T; Tanabe, T; Zhong, C | 1 |
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| Blennerhassett, MG; Liu, H; Lourenssen, S; Miller, DV; Paterson, WG; Wells, RW | 1 |
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| Alajbeg, IZ; Boras, VV; Brailo, V; Lukac, J; Lukac, M; Savage, NW | 1 |
| Bechrakis, N; Dietrich, H; Dimmer, A; Fischer-Colbrie, R; Kieselbach, G; Schmid, E; Teuchner, B; Troger, J | 1 |
| Berner, J; Bilkei-Gorzo, A; Lagercrantz, H; Shvarev, Y; Wickström, R | 1 |
| Bilkei-Gorzó, A; Frisch, P; Rácz, I; Zimmer, A | 1 |
| Berner, J; Bilkei-Gorzo, A; Racz, I; Wickström, R; Zimmer, A; Zimmermann, J | 1 |
| Boyle, EM; Laing, IA; McIntosh, N; Smith, J; Stenson, BJ; Stephen, RI; Wong, CM | 1 |
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| Imamura, T; Ishikawa, M; Ishizuka, O; Kurizaki, Y; Nishizawa, O; Noguchi, W; Zhang, L | 1 |
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55 review(s) available for substance p and neurokinin a
| Article | Year |
|---|---|
[Tachykinins in the central mechanisms of biological motivation].
Topics: Animals; Appetite; Appetite Depressants; Brain; Feeding Behavior; Models, Psychological; Neurokinin A; Neurokinin B; Rabbits; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1992 |
[Biosynthesis of substance P and other mammalian neurokinins].
Topics: Animals; Brain; Cattle; Humans; Neurokinin A; Neurokinin B; Neuropeptides; Protein Biosynthesis; Rats; Spinal Cord; Substance P; Swine; Transcription, Genetic | 1992 |
Neurokinin A and B.
Topics: Amino Acid Sequence; Animals; Humans; Molecular Sequence Data; Neurokinin A; Neurokinin B; Structure-Activity Relationship; Substance P; Tissue Distribution | 1991 |
Pulmonary physiology and pharmacology of neuropeptides.
Topics: Animals; Calcitonin Gene-Related Peptide; Humans; Hypersensitivity, Immediate; Inflammation; Lung; Neurokinin A; Neuropeptides; Substance P; Vasoactive Intestinal Peptide | 1991 |
Pharmacological and biochemical evidence for multiple types of tachykinin NK2 receptors.
Topics: Animals; Molecular Weight; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Concepts in characterization of tachykinin receptors.
Topics: Amino Acid Sequence; Animals; Molecular Sequence Data; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Sequence Homology, Nucleic Acid; Substance P; Tachykinins | 1991 |
Effects of various tachykinins on pituitary LH secretion, feeding, and sexual behavior in the rat.
Topics: Animals; Feeding Behavior; Female; Luteinizing Hormone; Male; Neurokinin A; Neurokinin B; Neuropeptides; Pituitary Gland, Anterior; Rats; Sexual Behavior, Animal; Substance P; Tachykinins | 1991 |
Molecular characterization of the three tachykinin receptors.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Molecular Sequence Data; Neurokinin A; Neurokinin B; Protein Conformation; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Sequence Homology, Nucleic Acid; Substance P; Tachykinins | 1991 |
Role of inositol phosphates in the actions of substance P on NK1 receptors in exocrine gland cells.
Topics: Animals; Calcium; Exocrine Glands; Inositol Phosphates; Models, Biological; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Signal Transduction; Substance P | 1991 |
[Recent advances in research on substance P and related neuropeptides].
Topics: Amino Acid Sequence; Animals; Base Sequence; Cats; Central Nervous System; Guinea Pigs; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Neurons; Neurotransmitter Agents; Oligopeptides; Rats; Substance P | 1985 |
Interactions between neuropeptides and dopamine neurons in the ventromedial mesencephalon.
Topics: Animals; Behavior, Animal; Cats; Cholecystokinin; Dopamine; Enkephalins; Haplorhini; Humans; Limbic System; Mesencephalon; Nerve Tissue Proteins; Neurokinin A; Neurotensin; Rats; Schizophrenia; Substance P; Swine | 1985 |
Brain enzymes as receptors: angiotensin-converting enzyme and enkephalin convertase.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Captopril; Carboxypeptidase H; Carboxypeptidases; Monoamine Oxidase; Nerve Tissue Proteins; Neurokinin A; Peptidyl-Dipeptidase A; Phorbol Esters; Protein Kinase C; Pyridines; Rats; Receptors, Cell Surface; Receptors, Drug; Substance P; Succinates; Tritium | 1986 |
Pharmacological receptors for substance P and neurokinins.
Topics: Animals; Dogs; Guinea Pigs; Neurokinin A; Neurokinin B; Neuropeptides; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1987 |
Neuropeptides and the pathogenesis of allergy.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Humans; Hypersensitivity; Inflammation; Mast Cells; Neurokinin A; Neuropeptides; Peripheral Nerves; Substance P | 1987 |
Peptides as neuromodulators in primary sensory neurons.
Topics: Amino Acid Sequence; Animals; Calcitonin Gene-Related Peptide; Neurokinin A; Neurokinin B; Neurons, Afferent; Neuropeptides; Neurotransmitter Agents; Substance P | 1987 |
Substance P antagonists and analgesia: a review of the hypothesis.
Topics: Amino Acid Sequence; Analgesics; Animals; Molecular Sequence Data; Neurokinin A; Neurokinin B; Species Specificity; Substance P | 1988 |
Control of vascular permeability and vascular smooth muscle in the respiratory tract by multiple neuropeptides.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Capillary Permeability; Eledoisin; Humans; Muscle, Smooth, Vascular; Neurokinin A; Neuropeptides; Respiratory Physiological Phenomena; Substance P; Tachykinins | 1989 |
Species variants of tachykinin receptor types.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cricetinae; Guinea Pigs; Kinetics; Molecular Sequence Data; Neurokinin A; Neurokinin B; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sequence Homology, Amino Acid; Species Specificity; Substance P; Urinary Bladder | 1994 |
[Neuropeptides of the nasal innervation and allergic rhinitis].
Topics: Allergens; Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Humans; Mast Cells; Microcirculation; Nasal Mucosa; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rhinitis, Allergic, Perennial; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1994 |
Neuropeptides in nasal mucosa.
Topics: Bradykinin; Calcitonin Gene-Related Peptide; Cytokines; Eicosanoids; Histamine H1 Antagonists; Humans; Nasal Mucosa; Nasal Polyps; Neurokinin A; Neuropeptide Y; Platelet Activating Factor; Receptors, Calcitonin Gene-Related Peptide; Rhinitis; Substance P; Vasoactive Intestinal Peptide | 1994 |
Protons: small stimulants of capsaicin-sensitive sensory nerves.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrophysiology; Guinea Pigs; Neurokinin A; Neurons, Afferent; Protons; Rats; Ruthenium Red; Substance P | 1994 |
Peptide-based tachykinin NK2 receptor antagonists.
Topics: Animals; Dipeptides; Humans; Neurokinin A; Neurokinin B; Oligopeptides; Peptide Fragments; Peptides; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1995 |
Tachykinin non-peptide antagonists: binding domain and molecular mode of action.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Biphenyl Compounds; GTP-Binding Proteins; Humans; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Receptors, Tachykinin; Recombinant Fusion Proteins; Substance P; Tachykinins | 1995 |
Peptidase modulation of airway effects of neuropeptides.
Topics: Amino Acid Sequence; Animals; Humans; Inflammation; Molecular Sequence Data; Neprilysin; Neurokinin A; Neuropeptides; Respiratory Physiological Phenomena; Respiratory System; Substance P; Vasoactive Intestinal Peptide | 1993 |
[Substance P receptor antagonist].
Topics: Amino Acid Sequence; Animals; Dactinomycin; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Platelet Aggregation; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
Substance P receptor (NK-1) in the central nervous system: possible functions from a morphological aspect.
Topics: Acetylcholine; Animals; Brain; Neurokinin A; Pain; Receptors, Glutamate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P | 1993 |
Participation of substance P in spinal physiological responses to peripheral aversive stimulation.
Topics: Animals; Biphenyl Compounds; Hypnotics and Sedatives; Neurokinin A; Neurons; Pain; Receptors, Neurokinin-2; Reflex; Spinal Cord; Substance P | 1993 |
The differential roles of substance P and neurokinin A in spinal cord hyperexcitability and neurogenic inflammation.
Topics: Afferent Pathways; Animals; Inflammation; Muscles; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Skin; Spinal Cord; Substance P | 1993 |
Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor.
Topics: Amino Acid Sequence; Animals; Epitopes; Kinetics; Ligands; Models, Structural; Molecular Sequence Data; Neurokinin A; Protein Structure, Secondary; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Interactions and coexistence of neuropeptides and serotonin in spinal autonomic systems.
Topics: Animals; Autonomic Nervous System; Ganglia, Sympathetic; Humans; Models, Neurological; Neurokinin A; Neuropeptides; Serotonin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1996 |
Beta-blocker induced asthma: a role for sensory nerve hyperresponsiveness?
Topics: Adrenergic beta-Antagonists; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Humans; Neurokinin A; Neurons, Afferent; Substance P | 1996 |
Tachykinins in the gut. Part I. Expression, release and motor function.
Topics: Animals; Esophagus; Gastric Mucosa; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Intestinal Mucosa; Nerve Fibers; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Signal Transduction; Substance P | 1997 |
Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation.
Topics: Animals; Digestive System; Digestive System Physiological Phenomena; Gastric Mucosa; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Neurokinin A; Neurons, Afferent; Pancreas; Receptors, Tachykinin; Regional Blood Flow; Saliva; Signal Transduction; Substance P; Synaptic Transmission | 1997 |
Hematopoietic modulation by the tachykinins.
Topics: Animals; Hematopoiesis; Humans; Neurokinin A; Substance P; Tachykinins | 1997 |
Neurogenic vasodilatation and plasma leakage in the skin.
Topics: Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Humans; Neurokinin A; Neurons, Afferent; Neuropeptides; Skin; Substance P; Vasodilation | 1998 |
Hematopoietic regulation mediated by interactions among the neurokinins and cytokines.
Topics: Animals; Bone Marrow Cells; Hematopoiesis; Humans; Neurokinin A; Receptors, Neurokinin-2; Stromal Cells; Substance P | 1997 |
Efferent functions of C-fiber nociceptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Efferent Pathways; Fibromyalgia; Humans; Inflammation; Nerve Fibers; Neurokinin A; Nociceptors; Skin; Substance P; Swine | 1998 |
Distinct neurochemical features of acute and persistent pain.
Topics: Acute Disease; Animals; Chronic Disease; Humans; Isoenzymes; Mice; Mice, Knockout; Neurochemistry; Neurokinin A; Pain; Protein Kinase C; Protein Precursors; Substance P; Tachykinins | 1999 |
Role of tachykinins in asthma.
Topics: Asthma; Humans; Lung; Neurogenic Inflammation; Neurokinin A; Neurons, Afferent; Receptors, Tachykinin; Substance P | 2000 |
Neurokinin mediation of edema and inflammation.
Topics: Animals; Edema; Humans; Inflammation; Neurokinin A; Neurokinin B; Substance P; Tachykinins | 2000 |
Actions of tachykinins within the heart and their relevance to cardiovascular disease.
Topics: Action Potentials; Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Cardiovascular Diseases; Cholinergic Fibers; Coronary Vessels; Ganglia; Heart; Hemodynamics; Humans; Myocardial Ischemia; Neurokinin A; Receptors, Tachykinin; Substance P; Tachykinins | 2000 |
Physiology of meningeal innervation: aspects and consequences of chemosensitivity of meningeal nociceptors.
Topics: Afferent Pathways; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Dinoprostone; Disease Models, Animal; Headache; Humans; Meninges; Neurokinin A; Neuropeptides; Nociceptors; Prostaglandins; Substance P | 2001 |
Tachykinin receptors in the gut: physiological and pathological implications.
Topics: Animals; Colonic Diseases, Functional; Digestive System; Digestive System Physiological Phenomena; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Inflammatory Bowel Diseases; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 2001 |
[The research progress on preprotachykinin].
Topics: Animals; Humans; Neurokinin A; Protein Precursors; RNA, Messenger; Substance P; Tachykinins | 1999 |
[Role of neurotrophin and neuropeptides in bronchial asthma].
Topics: Asthma; Calcitonin Gene-Related Peptide; Humans; Nerve Growth Factor; Neurokinin A; Neuropeptides; Substance P | 2004 |
The role of tachykinins in central nervous system inflammatory responses.
Topics: Animals; Astrocytes; Central Nervous System; Humans; Inflammation; Microglia; Neurokinin A; Neurokinin B; Neurons; Oligodendroglia; Substance P; Tachykinins | 2004 |
Non-neuronal mammalian tachykinin expression.
Topics: Animals; Gene Expression Regulation; Ligands; Neurokinin A; Neurokinin B; Peptides; Physalaemin; Protein Binding; Receptors, Neurokinin-1; Substance P; Tachykinins | 2004 |
Tachykinin-mediated modulation of the immune response.
Topics: Animals; Antiviral Agents; Bone Marrow; Hematopoietic Stem Cells; Humans; Immune System; Infections; Inflammation; Neurokinin A; Neurons; Receptors, Neurokinin-1; Substance P; T-Lymphocytes; Tachykinins | 2004 |
Selective and combined neurokinin receptor antagonists.
Topics: Animals; Central Nervous System Diseases; Drug Combinations; Gastrointestinal Diseases; Humans; Lung Diseases; Neurokinin A; Neurokinin B; Pain; Receptors, Tachykinin; Substance P; Urologic Diseases; Vomiting | 2005 |
Extending the understanding of sensory neuropeptides.
Topics: Animals; Asthma; Bronchoconstriction; Clinical Trials as Topic; Disease Models, Animal; Humans; Neurokinin A; Neurons, Afferent; Neurotransmitter Agents; Pulmonary Disease, Chronic Obstructive; Receptors, Tachykinin; Respiratory System; Respiratory System Agents; Substance P | 2006 |
Neurokinin3 receptor regulation of the airways.
Topics: Animals; Central Nervous System; Humans; Lung; Models, Neurological; Neurokinin A; Neurotransmitter Agents; Receptors, Neurokinin-3; Substance P | 2006 |
Neuropeptides in dental pulp: the silent protagonists.
Topics: Alveolar Bone Loss; Animals; Calcitonin Gene-Related Peptide; Dental Pulp; Humans; Neurogenic Inflammation; Neurokinin A; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Pulpitis; Substance P; Toothache; Vasoactive Intestinal Peptide | 2008 |
Tachykinin receptors antagonism for asthma: a systematic review.
Topics: Anti-Asthmatic Agents; Asthma; Humans; Neurokinin A; Neurokinin B; Receptors, Tachykinin; Substance P; Treatment Outcome | 2011 |
Neuropeptide effects in the trigeminal system: pathophysiology and clinical relevance in migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dura Mater; Humans; Membrane Potentials; Migraine Disorders; Neurokinin A; Neuropeptide Y; Piperazines; Quinazolines; Receptors, Calcitonin Gene-Related Peptide; Substance P; Trigeminal Ganglion; Trigeminal Nucleus, Spinal; Vasoactive Intestinal Peptide | 2011 |
Tachykinin NK
Topics: Humans; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Substance P; Tachykinins | 2021 |
11 trial(s) available for substance p and neurokinin a
| Article | Year |
|---|---|
Cutaneous responses to vasoactive intestinal polypeptide in chronic idiopathic urticaria.
Topics: Adult; Calcitonin Gene-Related Peptide; Chronic Disease; Female; Humans; Intradermal Tests; Male; Microcirculation; Middle Aged; Neurokinin A; Skin; Substance P; Urticaria; Vasoactive Intestinal Peptide | 1992 |
The effects of enalapril and sulindac on the dermal response to substance P and neurokinin A.
Topics: Adult; Double-Blind Method; Enalapril; Humans; Male; Neurokinin A; Random Allocation; Skin; Skin Tests; Substance P; Sulindac | 1991 |
Comparison of neurokinin A and substance P on cardiovascular and airway function in man.
Topics: Adult; Female; Hemodynamics; Humans; Male; Neurokinin A; Neuropeptides; Substance P; Trachea | 1988 |
Pentagastrin infusions in patients with panic disorder. II. Neuroendocrinology.
Topics: Adrenocorticotropic Hormone; Adult; Agoraphobia; Arousal; Catecholamines; Female; Growth Hormone; Hormones; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Neurokinin A; Panic Disorder; Pentagastrin; Pituitary-Adrenal System; Receptors, Cholecystokinin; Single-Blind Method; Substance P; Vasoactive Intestinal Peptide | 1994 |
Neuropeptides in the saliva of healthy subjects.
Topics: Adult; Calcitonin Gene-Related Peptide; Citric Acid; Female; Humans; Male; Mastication; Neurokinin A; Neuropeptide Y; Neuropeptides; Parotid Gland; Radioimmunoassay; Saliva; Salivary Glands; Substance P; Vasoactive Intestinal Peptide | 1997 |
The influence of sensory stimulation (acupuncture) on the release of neuropeptides in the saliva of healthy subjects.
Topics: Acupuncture Therapy; Adult; Calcitonin Gene-Related Peptide; Citric Acid; Electroacupuncture; Female; Humans; Kinetics; Male; Mastication; Neurokinin A; Neuropeptide Y; Neuropeptides; Parotid Gland; Saliva; Substance P; Vasoactive Intestinal Peptide | 1998 |
Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma.
Topics: Adult; Albumins; alpha-Macroglobulins; Asthma; Biomarkers; Capillary Permeability; Ceruloplasmin; Cross-Over Studies; Female; Fibrinogen; Humans; Male; Neurokinin A; Single-Blind Method; Sputum; Statistics, Nonparametric; Substance P | 2002 |
Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans.
Topics: Adolescent; Adult; Blood Pressure; Diastole; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Intestinal Mucosa; Intestine, Small; Laser-Doppler Flowmetry; Male; Manometry; Myoelectric Complex, Migrating; Neurokinin A; Pulse; Regional Blood Flow; Skin; Statistics, Nonparametric; Stimulation, Chemical; Substance P | 2003 |
Sputum substance P and neurokinin A are reduced during exacerbations of chronic obstructive pulmonary disease.
Topics: Aged; Female; Humans; Male; Middle Aged; Neurokinin A; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Smoking; Sputum; Substance P | 2005 |
Stromal derived growth factor-1alpha: another mediator in neural-emerging immune system through Tac1 expression in bone marrow stromal cells.
Topics: Adolescent; Adult; Bone Marrow Cells; Cells, Cultured; Chemokine CXCL12; Chemokines, CXC; Dose-Response Relationship, Drug; Female; Hematopoiesis; Humans; Male; Nerve Tissue; Neurokinin A; NF-kappa B; Protein Precursors; Stromal Cells; Substance P; Tachykinins | 2007 |
Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.
Topics: Acetates; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Asthma, Aspirin-Induced; Cell Count; Cyclopropanes; Cysteine; Eosinophils; Female; Humans; Leukotriene Antagonists; Leukotrienes; Male; Middle Aged; Nasal Lavage Fluid; Nasal Polyps; Neurokinin A; Quinolines; Substance P; Sulfides; Treatment Outcome | 2011 |
1053 other study(ies) available for substance p and neurokinin a
| Article | Year |
|---|---|
The N-terminal domain of substance P is required for complete homologous desensitization but not phosphorylation of the rat neurokinin-1 receptor.
Topics: Animals; Cell Line, Transformed; Inositol 1,4,5-Trisphosphate; Kidney; Neurokinin A; Peptide Fragments; Phosphorylation; Protein Structure, Tertiary; Rats; Receptors, Neurokinin-1; Second Messenger Systems; Substance P; Transfection | 2001 |
A new class of high affinity ligands for the neurokinin A NK2 receptor: psi (CH2NR) reduced peptide bond analogues of neurokinin A4-10.
Topics: Amino Acid Sequence; Animals; Cricetinae; In Vitro Techniques; Ligands; Molecular Sequence Data; Neurokinin A; Oxidation-Reduction; Peptide Fragments; Phosphatidylinositols; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Urinary Bladder | 1992 |
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Lactams; Male; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Protein Conformation; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Structure-Activity Relationship; Tachykinins | 1992 |
Synthesis and immunological evaluation of N-terminal, noncrossreactive tachykinin antigens.
Topics: Animals; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred BALB C; Neurokinin A; Neurokinin B; Substance P; Tachykinins | 1988 |
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Cricetinae; Duodenum; Guinea Pigs; In Vitro Techniques; Kinetics; Mesocricetus; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1993 |
Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.
Topics: Amino Acid Sequence; Animals; Autoradiography; Brain; Guinea Pigs; Male; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Radioligand Assay; Stereoisomerism; Substance P | 1993 |
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Dogs; Humans; Mice; Piperidines; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin | 1997 |
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Fluorescent Dyes; Fura-2; Humans; Lactams; Molecular Conformation; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spectrometry, Fluorescence; Structure-Activity Relationship | 1998 |
Asymmetric synthesis of Boc-N-methyl-p-benzoyl-phenylalanine. Preparation of a photoreactive antagonist of substance P.
Topics: Alkylation; Animals; Biotin; CHO Cells; Cricetinae; Cyclic AMP; Humans; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Phenylalanine; Photochemistry; Receptors, Neurokinin-2; Structure-Activity Relationship; Substance P | 1998 |
Importance of the aromatic residue at position 6 of [Nle(10)]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Structure-Activity Relationship; Trachea | 1999 |
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
Topics: Amino Acid Sequence; Animals; Calcium; Cloning, Molecular; Humans; Mice; Molecular Sequence Data; Neurokinin A; Quinolines; Receptors, Neurokinin-3 | 2001 |
Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Blood Pressure; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Ileum; Male; Muscle, Smooth; Protein Precursors; Pulmonary Artery; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Saliva; Salivation; Sequence Homology, Amino Acid; Tachykinins; Urinary Bladder | 2002 |
Tachykinin systems in the spinal cord and basal ganglia: influence of neonatal capsaicin treatment or dopaminergic intervention on levels of peptides, substance P-encoding mRNAs, and substance P receptor mRNA.
Topics: Animals; Animals, Newborn; Basal Ganglia; Blotting, Northern; Capsaicin; Chromatography, High Pressure Liquid; Dopamine Agents; Dynorphins; Endorphins; Female; Haloperidol; Injections, Subcutaneous; Neurokinin A; Neurons; Neurotoxins; Pregnancy; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; RNA, Messenger; Spinal Cord; Substance P; Tachykinins | 1992 |
Neurokinin A-stimulated phosphoinositide breakdown in rabbit iris sphincter muscle.
Topics: Animals; Atropine; Binding, Competitive; Calcium; Female; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Neurokinin A; Oculomotor Muscles; Phosphatidylinositols; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons.
Topics: Animals; Calcium; Cations; Chlorides; In Vitro Techniques; Ion Channel Gating; Ion Channels; Locus Coeruleus; Magnesium; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Potassium; Potassium Channels; Rats; Substance P; Tetrodotoxin | 1992 |
Neurokinin 1 receptors mediate substance P-induced changes in ion transport in guinea-pig ileum.
Topics: Animals; Biological Transport, Active; Electric Stimulation; Electrochemistry; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Ions; Male; Neurokinin A; Piroxicam; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Tetrodotoxin | 1992 |
The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides.
Topics: Amino Acid Sequence; Animals; Cell Line; Glutamates; Glutamic Acid; Glycosylation; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Neurokinin B; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P; Transfection; Valine | 1992 |
Role of tachykinins in the control of pancreatic secretion and circulation.
Topics: Amino Acid Sequence; Amylases; Anesthesia; Animals; Dogs; Dose-Response Relationship, Drug; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Oxygen Consumption; Pancreas; Pancreatic Hormones; Rats; Rats, Wistar; Regional Blood Flow; Stimulation, Chemical; Substance P; Tachykinins | 1992 |
Immunochemical characterisation of tachykinin immunoreactivity in the nervous system of the garden snail, Helix aspersa.
Topics: Amino Acid Sequence; Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Eledoisin; Fluorescent Antibody Technique; Helix, Snails; Kassinin; Molecular Sequence Data; Nervous System; Neurokinin A; Neurons; Radioimmunoassay; Substance P; Tachykinins | 1992 |
Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation.
Topics: Amino Acid Sequence; Animals; Capillary Permeability; Histamine; Male; Molecular Sequence Data; Neurokinin A; Nicotiana; Oligopeptides; Peptides, Cyclic; Plants, Toxic; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Smoke; Substance P; Tachykinins; Trachea | 1992 |
[Pro9]SP and [pGlu6, Pro9]SP(6-11) interact with two different receptors in the guinea-pig ileum as demonstrated with new SP antagonists.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Duodenum; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Neurokinin A; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Synaptosomes | 1992 |
Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2, and NK3 tachykinin receptors.
Topics: Animals; Atropine; Corpus Striatum; Dopamine; Male; Neurokinin A; Neurokinin B; Pempidine; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Membranes; Synaptic Transmission; Tetrodotoxin | 1992 |
Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Membrane; Chlorides; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Neurokinin B; Oocytes; Polymerase Chain Reaction; Protein Conformation; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins; Substance P; Xenopus | 1992 |
Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cloning, Molecular; Humans; Indoles; Isoindoles; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Protein Conformation; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Recombinant Proteins; Substance P | 1992 |
Enhanced responsiveness of ovalbumin-sensitized guinea-pig alveolar macrophages to tachykinins.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Glucuronidase; Guinea Pigs; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Ovalbumin; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Superoxides; Tachykinins; Thromboxane B2 | 1992 |
Characterization of NK-1 receptors in guinea pig and rat brain membranes with NK-1 peptides and a non-peptide antagonist.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Brain; Guinea Pigs; Membranes; Molecular Sequence Data; Neurokinin A; Neurokinin B; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
Electroconvulsive stimuli and brain peptides: effect of modification of seizure duration on neuropeptide Y, neurokinin A, substance P and neurotensin.
Topics: Animals; Brain; Diazepam; Eicosanoids; Electroshock; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Neurotensin; Rats; Rats, Sprague-Dawley; Seizures; Substance P; Time Factors; Tissue Distribution | 1992 |
Pattern of substance P- and cholecystokinin-like immunoreactivity during regeneration of the neural complex in the ascidian Ciona intestinalis.
Topics: Animals; Cholecystokinin; Ganglia; In Vitro Techniques; Insulin; Nerve Regeneration; Neurokinin A; Substance P; Urochordata | 1992 |
A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder.
Topics: Animals; Carbachol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1992 |
Effect of the NEP inhibitor SCH32615 on airway responses to intravenous substance P in guinea pigs.
Topics: Airway Resistance; Animals; Blood Pressure; Captopril; Dipeptides; Guinea Pigs; Injections, Intravenous; Male; Neprilysin; Neurokinin A; Substance P; Thiorphan | 1992 |
Structural characterization of tachykinins (neuropeptide gamma, neurokinin A, and substance P) from a reptile, Alligator mississipiensis.
Topics: Alligators and Crocodiles; Amino Acid Sequence; Animals; Brain; Chromatography, Gel; Chromatography, High Pressure Liquid; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Radioimmunoassay; Sequence Homology, Amino Acid; Substance P; Tachykinins | 1992 |
Calcitonin gene-related peptide (CGRP) activates human neutrophils--inhibition by chemotactic peptide antagonist BOC-MLP.
Topics: Calcitonin Gene-Related Peptide; Calcium; Cells, Cultured; Humans; Lactoferrin; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Neutrophils; Oligopeptides; Pertussis Toxin; Substance P; Virulence Factors, Bordetella | 1992 |
Substance P and neurokinin A immunoreactive nerve fibres in the developing salivary glands of the rat.
Topics: Adsorption; Animals; Female; Immunohistochemistry; Nerve Fibers; Neurokinin A; Parotid Gland; Pregnancy; Rats; Rats, Wistar; Salivary Glands; Submandibular Gland; Substance P | 1992 |
Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat.
Topics: Animals; Animals, Newborn; Endopeptidases; In Vitro Techniques; Neurokinin A; Neurotransmitter Agents; Protease Inhibitors; Rats; Rats, Wistar; Reflex, Monosynaptic; Spinal Cord; Substance P; Synapses; Synaptic Transmission; Tachykinins | 1992 |
Effects of trigeminal neurotransmitters on piglet pial arterioles.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arginine; Arterioles; Brain; Calcitonin Gene-Related Peptide; Dinoprostone; Indomethacin; Neurokinin A; Nitric Oxide; omega-N-Methylarginine; Pia Mater; Substance P; Swine; Trigeminal Nerve | 1992 |
The motor actions of natural neurokinins and their specific agonists on the gastrointestinal tract of the rat.
Topics: Animals; Charcoal; Gastrointestinal Motility; Injections, Intraperitoneal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Pilot Projects; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1992 |
Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Involvement of neurokinin-2 receptors.
Topics: Aged; Aged, 80 and over; Atropine; Electric Stimulation; Humans; Ileum; In Vitro Techniques; Middle Aged; Muscle Contraction; Nervous System Physiological Phenomena; Neurokinin A; Radioimmunoassay; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Tetrodotoxin | 1992 |
Radioiodinated substance P, neurokinin A, and eledoisin bind predominantly in NK1 receptors in guinea pig lung.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Eledoisin; Guanylyl Imidodiphosphate; Guinea Pigs; Iodine Radioisotopes; Kinetics; Lung; Molecular Sequence Data; Neurokinin A; Protease Inhibitors; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Succinimides | 1992 |
Molecular cloning of the murine substance K and substance P receptor genes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cosmids; DNA; Female; Gene Expression; Mice; Molecular Sequence Data; Neurokinin A; Polymerase Chain Reaction; Protein Conformation; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Restriction Mapping; Substance P; Xenopus laevis | 1992 |
Effects of tachykinins on luteinizing hormone release in female rats: potent inhibitory action of neuropeptide K.
Topics: Animals; Dose-Response Relationship, Drug; Estradiol; Female; Gonadotropin-Releasing Hormone; Injections, Intraventricular; Luteinizing Hormone; Neurokinin A; Neuropeptides; Ovariectomy; Pituitary Gland; Potassium; Progesterone; Radioimmunoassay; Rats; Substance P; Tachykinins; Time Factors | 1992 |
Postnatal changes in the substance P receptor on rabbit gastric smooth muscle.
Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Dose-Response Relationship, Drug; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Osmolar Concentration; Rabbits; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Stomach; Substance P; Tachykinins; Time Factors | 1992 |
Cortisol secretion induced by substance P from bovine adrenocortical cells and its inhibition by calmodulin inhibitors.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Calcium; Calmodulin; Cattle; Cyclic AMP; Dose-Response Relationship, Drug; Hydrocortisone; Imidazoles; Neurokinin A; Neurokinin B; Signal Transduction; Substance P; Sulfonamides; Trifluoperazine | 1992 |
Chromatographic evidence for the presence of multiple tachykinins in the bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Chromatography, High Pressure Liquid; Neurokinin A; Neuropeptides; Peptide Fragments; Radioimmunoassay; Substance P; Tachykinins | 1992 |
Adenosine A1 receptors mediate inhibition of tachykinin release from perifused enteric nerve endings.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dimethylphenylpiperazinium Iodide; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Phenethylamines; Potassium; Receptors, Purinergic; Structure-Activity Relationship; Substance P; Synaptosomes; Veratridine | 1992 |
Evidence of NK1 and NK2 tachykinin receptors and their involvement in histamine release in a murine mast cell line.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cell Membrane; Histamine Release; Mast Cells; Mice; Molecular Sequence Data; Neurokinin A; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Peptides; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
An ubiquitous modulating function of rabbit tracheal epithelium: degradation of tachykinins.
Topics: Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Choline; Electric Stimulation; Epithelium; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Protease Inhibitors; Rabbits; Substance P; Tachykinins; Trachea | 1992 |
Tracheal smooth muscle responses to substance P and neurokinin A in the piglet.
Topics: Animals; Animals, Newborn; Blood Pressure; Muscle Contraction; Muscle Development; Muscle, Smooth; Neprilysin; Neurokinin A; Substance P; Swine; Trachea | 1992 |
Antagonists that demonstrate species differences in neurokinin-1 receptors.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Biphenyl Compounds; Cell Line; Guinea Pigs; Humans; Molecular Sequence Data; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Species Specificity; Structure-Activity Relationship; Substance P | 1992 |
Intrathecal neurokinin A facilitates the spinal nociceptive flexor reflex evoked by thermal and mechanical stimuli and synergistically interacts with substance P.
Topics: Animals; Drug Synergism; Electric Stimulation; Electromyography; Hot Temperature; Injections, Spinal; Neurokinin A; Nociceptors; Physical Stimulation; Rats; Rats, Inbred Strains; Reflex, Stretch; Substance P | 1992 |
cDNA sequence and heterologous expression of the human neurokinin-3 receptor.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cell Line; Chloride Channels; Chlorides; Cloning, Molecular; DNA; Gene Expression; Humans; Kinetics; Membrane Proteins; Molecular Sequence Data; Neurokinin A; Oocytes; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins; RNA, Messenger; Sequence Homology, Nucleic Acid; Substance P; Transfection; Xenopus | 1992 |
Molecular cloning of substance P receptor cDNA from guinea-pig uterus.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Recombinant; Female; Guinea Pigs; Molecular Sequence Data; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Uterus | 1992 |
Neurokinin receptors and mucosal ion transport in porcine jejunum.
Topics: Animals; Autoradiography; Binding Sites; Biological Transport, Active; Female; Intestinal Mucosa; Jejunum; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Succinimides; Swine | 1992 |
Substance-P-related and neurokinin-A-related peptides from the brain of the cod and trout.
Topics: Amino Acid Sequence; Amino Acids; Animals; Brain Chemistry; Fishes; Molecular Sequence Data; Neurokinin A; Radioimmunoassay; Substance P; Trout | 1992 |
Tachykinin-induced dyspnea in conscious guinea pigs.
Topics: Aerosols; Animals; Drug Interactions; Dyspnea; Guinea Pigs; Male; Neurokinin A; SRS-A; Substance P; Thiorphan | 1992 |
Nervous control of the release of substance P and neurokinin A from the isolated perfused porcine ileum.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Chromatography, Gel; Electric Stimulation; Ileum; In Vitro Techniques; Neurokinin A; Norepinephrine; Perfusion; Phentolamine; Radioimmunoassay; Substance P; Swine | 1992 |
FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Cerebral Cortex; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1992 |
Distribution of neurokinin B in rat spinal cord and peripheral tissues: comparison with neurokinin A and substance P and effects of neonatal capsaicin treatment.
Topics: Animals; Animals, Newborn; Capsaicin; Ganglia, Spinal; Guinea Pigs; Male; Neurokinin A; Neurokinin B; Organ Specificity; Radioimmunoassay; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Cord; Substance P | 1992 |
The effect of tachykinins on sheep bronchomotor tone.
Topics: Animals; Atropine; Bronchi; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Hexamethonium Compounds; Injections, Intravenous; Motor Neurons; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Sheep; Substance P; Tachykinins; Vasoconstriction | 1992 |
Mechanisms of action of the dilatory response to calcitonin gene-related peptide in guinea pig basilary artery.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Basilar Artery; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Cromakalim; Cyclic AMP; Endothelium, Vascular; Glyburide; Guinea Pigs; In Vitro Techniques; Muscle, Smooth, Vascular; Neurokinin A; Nitric Oxide; Potassium Channels; Pyrroles; Second Messenger Systems; Substance P; Vasodilation; Vasodilator Agents | 1992 |
CGRP modulates nerve-mediated vasoconstriction of rat knee joint blood vessels.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Electric Stimulation; Humans; Joints; Male; Muscle, Smooth, Vascular; Nerve Fibers; Neurokinin A; Neurokinin B; Neuropeptides; Peripheral Nerves; Rats; Rats, Inbred Strains; Regional Blood Flow; Substance P; Vasoconstriction; Vasodilation | 1992 |
Neurokinin agonists differentially affect A9 and A10 dopamine cells in the rat.
Topics: Animals; Dopamine; Neurokinin A; Neurons; Peptide Fragments; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1992 |
Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Substance P; Synaptic Transmission; Tachykinins | 1992 |
Differences in neurokinin receptor pharmacology between rat and guinea-pig superior cervical ganglia.
Topics: Animals; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Neurokinin A; Neurokinin B; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Species Specificity; Substance P | 1992 |
Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanism of action.
Topics: Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intraventricular; Luteinizing Hormone; Male; Neurokinin A; Neurokinin B; Neuropeptides; Orchiectomy; Peptide Fragments; Rats; Rats, Inbred Strains; Reference Values; Substance P; Tachykinins | 1992 |
Bronchial epithelial cells release neutrophil chemotactic activity in response to tachykinins.
Topics: Animals; Bronchi; Epithelial Cells; Epithelium; Interleukin-8; Neprilysin; Neurokinin A; Neurokinin B; Peptide Fragments; Protease Inhibitors; Substance P; Tachykinins | 1992 |
Modulation of excitatory amino acid responses in rat dorsal horn neurons by tachykinins.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Calcium; Cesium; Colforsin; Glycine; Ibotenic Acid; In Vitro Techniques; N-Methylaspartate; Neurokinin A; Neurons; Peptides; Phorbol Esters; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P; Tachykinins | 1992 |
The effects of neuropeptides on mucous glycoprotein secretion from human nasal mucosa in vitro.
Topics: Calcitonin Gene-Related Peptide; Gastrin-Releasing Peptide; Glycoproteins; Methacholine Chloride; Nasal Mucosa; Neurokinin A; Neuropeptide Y; Neuropeptides; Organ Culture Techniques; Peptides; Substance P; Vasoactive Intestinal Peptide | 1992 |
Tachykinins preferentially excite certain complex cells in the infragranular layers of feline striate cortex.
Topics: Animals; Cats; Evoked Potentials, Visual; Female; Iontophoresis; Male; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Substance P; Tachykinins; Visual Cortex | 1992 |
Behavioural consequences following infusion of selective neurokinin agonists into the median raphe nucleus of the rat.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Injections; Molecular Sequence Data; Motor Activity; Neurokinin A; Peptide Fragments; Raphe Nuclei; Rats; Substance P | 1992 |
Fast and slow depolarizations produced by substance P and other tachykinins in sympathetic neurons of rat prevertebral ganglia.
Topics: Animals; Chromatography, High Pressure Liquid; Electrophysiology; Ganglia, Sympathetic; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neuromuscular Depolarizing Agents; Neurons; Radioimmunoassay; Rats; Substance P; Tachykinins; Temperature | 1992 |
Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw.
Topics: Animals; Autonomic Nervous System; Electric Stimulation; Foot; Histamine; Male; Microcirculation; Neurokinin A; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Serotonin; Skin; Skin Physiological Phenomena; Substance P; Tachykinins | 1992 |
Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors.
Topics: Animals; Cell Line; Cell Membrane; DNA; Iodine Radioisotopes; Models, Biological; Neurokinin A; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Restriction Mapping; Signal Transduction; Substance P; Substrate Specificity; Transfection | 1992 |
Effects of the tripeptide substance P antagonist, FR113680, on airway constriction and airway edema induced by neurokinins in guinea-pigs.
Topics: Amino Acid Sequence; Animals; Bronchi; Bronchoconstriction; Capsaicin; Electric Stimulation; Guinea Pigs; Histamine; Kinins; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Oligopeptides; Pulmonary Edema; Substance P; Trachea | 1992 |
Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists.
Topics: Analgesics; Animals; Behavior, Animal; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Opioid; Spinal Cord; Substance P | 1992 |
Carboxypeptidase M-like enzyme modulates the noncholinergic bronchoconstrictor response in guinea pig.
Topics: 3-Mercaptopropionic Acid; Animals; Bradykinin; Bronchoconstriction; Capsaicin; Electric Stimulation; GPI-Linked Proteins; Guinea Pigs; Histamine; Male; Metalloendopeptidases; Neurokinin A; Receptors, Cholinergic; Substance P; Vagus Nerve | 1992 |
Tachykinin receptors in the guinea-pig renal pelvis: activation by exogenous and endogenous tachykinins.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Kidney Pelvis; Male; Molecular Sequence Data; Muscle Contraction; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies.
Topics: Amino Acid Sequence; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1992 |
Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biphenyl Compounds; Electric Stimulation; Injections, Spinal; Nerve Fibers; Neurokinin A; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P; Sural Nerve | 1992 |
Identification of the central tachykinin receptor subclass involved in substance P-induced cardiovascular and behavioral responses in conscious rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1992 |
Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs.
Topics: Animals; Captopril; Dipeptides; Guinea Pigs; Kinetics; Lung; Male; Neurokinin A; Peptide Hydrolases; Perfusion; Substance P; Thiorphan; Trachea | 1990 |
Neurokinin inhibition of cholinergic myenteric neurons in canine antrum.
Topics: Acetylcholine; Animals; Atropine; Dinoprostone; Dogs; Electric Stimulation; Enkephalin, Methionine; Female; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth; Myenteric Plexus; Naloxone; Neurokinin A; Neurons; Nifedipine; Phentolamine; Propranolol; Pyloric Antrum; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1990 |
Substance P and neurokinin A, two coexisting tachykinins stimulating the release of [3H]5-HT from rat cerebral cortical slices.
Topics: Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Male; Neurokinin A; Potassium; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1990 |
Neurokinin receptors mediating substance P-induced contraction in adult rabbit airways.
Topics: Animals; Atropine; Bronchi; Glycopeptides; In Vitro Techniques; Isometric Contraction; Kinetics; Muscle Contraction; Muscle, Smooth; Neostigmine; Neurokinin A; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1990 |
Studies on the coexistence of substance P with other putative transmitters in the nodose and petrosal ganglia.
Topics: Animals; Calcitonin Gene-Related Peptide; Glossopharyngeal Nerve; Immunohistochemistry; Male; Neurokinin A; Nodose Ganglion; Rats; Rats, Inbred Strains; Substance P; Tyrosine 3-Monooxygenase; Vagus Nerve | 1990 |
Peptide-containing nerve fibers in the circumvallate papillae.
Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Cattle; Ferrets; Haplorhini; Mice; Nerve Fibers; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Substance P; Swine; Tongue; Vasoactive Intestinal Peptide | 1990 |
Receptors for neurokinins in human bronchus and urinary bladder are of the NK-2 type.
Topics: Bronchi; Humans; In Vitro Techniques; Middle Aged; Muscle, Smooth; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1990 |
Dual effects of capsaicin on responses of the rabbit ear artery to field stimulation.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Capsaicin; Ear, External; Electric Stimulation; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Muscle, Smooth, Vascular; Neurokinin A; Norepinephrine; Prostaglandins; Rabbits; Regional Blood Flow; Substance P; Sympathetic Nervous System; Synaptic Transmission | 1990 |
Effects of capsaicin, tachykinins, calcitonin gene-related peptide and bradykinin in the pig iris sphincter muscle.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; In Vitro Techniques; Iris; Neurokinin A; Radioimmunoassay; Substance P; Swine; Tachykinins | 1990 |
Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides.
Topics: Aged; Atropine; Electric Stimulation; Galanin; Humans; Ileum; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; omega-Conotoxins; Peptides; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1990 |
Capsaicin-induced bronchoconstriction and neuropeptide release in guinea pig perfused lungs.
Topics: Acetylcholine; Adenosine; Airway Resistance; Animals; Bronchi; Calcitonin Gene-Related Peptide; Capsaicin; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Guinea Pigs; Hydrogen-Ion Concentration; Lung; Lung Compliance; Male; Neurokinin A; Neuropeptides; Substance P; Tetrodotoxin | 1990 |
[Skin reactivity to substance P in asthmatics].
Topics: Adult; Asthma; Female; Humans; Male; Middle Aged; Neurokinin A; Peptide Fragments; Skin; Skin Tests; Substance P | 1990 |
Inhibition of salt appetite in the rat following injection of tachykinins into the medial amygdala.
Topics: Amygdala; Animals; Appetite; Desoxycorticosterone; Eledoisin; Male; Neurokinin A; Rats; Rats, Inbred Strains; Sodium, Dietary; Substance P; Tachykinins | 1990 |
Effect of the anti-asthmatic agent KC-404 on the contractile responses of rabbit airway smooth muscle to tachykinins.
Topics: Animals; Bronchodilator Agents; Chemical Phenomena; Chemistry; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Neurokinin A; Pyridines; Rabbits; Substance P; Tachykinins; Trachea | 1990 |
Tachykinins and calcitonin gene-related peptide in oxazolone-induced allergic contact dermatitis in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Dermatitis, Contact; Ear; Male; Mice; Mice, Inbred C57BL; Neurokinin A; Oxazoles; Oxazolone; Substance P; Tachykinins | 1990 |
Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice.
Topics: Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neurokinin A; Rats; Rats, Inbred Strains; Recombinant Proteins; Spinal Cord; Spinal Nerve Roots; Substance P | 1990 |
A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal "protective protein".
Topics: Amino Acid Sequence; Angiotensin I; Blood Platelets; Chromatography; Eledoisin; Esterases; Humans; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Lysosomes; Molecular Sequence Data; Molecular Weight; Neurokinin A; Peptide Hydrolases; Protease Inhibitors; Substance P; Substrate Specificity; Tachykinins | 1990 |
Potent and highly selective neurokinin antagonists.
Topics: Amino Acid Sequence; Animals; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Molecular Sequence Data; Molecular Structure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Protein Conformation; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1990 |
[Stimulation of mucous glands of the respiratory tract by neuropeptides: comparison of exogenous administration and endogenous liberation].
Topics: Animals; Exocrine Glands; Female; Ferrets; Male; Mucus; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1990 |
NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins.
Topics: Autoradiography; Cell Division; Fibroblasts; Humans; In Vitro Techniques; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Skin; Substance P; Tachykinins; Thiorphan; Thymidine | 1990 |
Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; DNA; Gene Expression Regulation; Male; Molecular Sequence Data; Neurokinin A; Nucleic Acid Conformation; Organ Specificity; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Inbred Strains; Restriction Mapping; RNA Splicing; RNA, Messenger; Sequence Homology, Nucleic Acid; Substance P; Tachykinins; Transcription, Genetic | 1990 |
[Localization and physiologic role of neuropeptides and their receptors--the tachykinin family of substance P, neurokinin A and neurokinin B].
Topics: Amino Acid Sequence; Animals; Binding Sites; Molecular Sequence Data; Nervous System; Neurokinin A; Neurokinin B; Neurotransmitter Agents; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1990 |
Regional distribution of neuropeptide gamma and other tachykinin peptides derived from the substance P gene in the rat.
Topics: Amino Acid Sequence; Animals; Brain; Chromatography, Gel; Chromatography, High Pressure Liquid; Duodenum; Male; Molecular Sequence Data; Neurokinin A; Organ Specificity; Peptide Fragments; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1990 |
An antagonist of neurokinin A, but not substance P, activity on tracheal smooth muscle from guinea-pig.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Substance P; Trachea | 1990 |
Immunoblockade by a specific tachykinin antiserum of the non-cholinergic contractile responses in the guinea-pig isolated bronchus.
Topics: Airway Resistance; Animals; Bronchi; Capsaicin; Electric Stimulation; Eledoisin; Guinea Pigs; Immune Sera; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Substance P | 1990 |
Capsaicin-sensitive and hexamethonium-insensitive circular muscle responses to mesenteric nerve stimulation in the isolated guinea pig ileum.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Ileum; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Substance P | 1990 |
Neutral endopeptidase inhibitor potentiates the tachykinin-induced increase in ciliary beat frequency in rabbit trachea.
Topics: Animals; Male; Mucociliary Clearance; Neprilysin; Neurokinin A; Rabbits; Stimulation, Chemical; Substance P; Thiorphan; Trachea | 1990 |
Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, kinins and angiotensins in isolated vessels.
Topics: Angiotensin II; Animals; Captopril; Carotid Arteries; Dogs; Female; In Vitro Techniques; Kinins; Leucine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Portal Vein; Protease Inhibitors; Pulmonary Artery; Rabbits; Rats; Rats, Inbred Strains; Substance P | 1990 |
Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, bradykinin and angiotensin in guinea pig, hamster and rat urinary bladders.
Topics: Angiotensin II; Animals; Cricetinae; Female; Guinea Pigs; In Vitro Techniques; Kinins; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder | 1990 |
Tachykinins activate guinea-pig alveolar macrophages: involvement of NK2 and NK1 receptors.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Macrophage Activation; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Neurokinin B; Pulmonary Alveoli; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P; Superoxides; Tachykinins | 1990 |
The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat.
Topics: Animals; Axons; Bombesin; Cats; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Hot Temperature; Kinetics; Neurokinin A; Neurons; Pain; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1990 |
Neurokinin A suppresses a voltage-gated K+ current in smooth muscle cells from rat vas deferens.
Topics: Action Potentials; Animals; Electrophysiology; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Potassium Channels; Rats; Rats, Inbred Strains; Substance P; Vas Deferens | 1990 |
Pharmacological profile of a tachykinin antagonist, spantide, as examined on rat spinal motoneurones.
Topics: Analgesics; Animals; Animals, Newborn; Motor Neurons; Neurokinin A; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P; Tachykinins; Tetrodotoxin | 1990 |
Studies on the vascular permeability induced by intrathecal substance P and bradykinin in the rat.
Topics: Adrenalectomy; Animals; Blood Proteins; Bradykinin; Capillary Permeability; Capsaicin; Decerebrate State; In Vitro Techniques; Injections, Spinal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Vagotomy | 1990 |
Characterization of eosinophil cell activation by peptides. Differential effects of substance P, melittin, and FMET-Leu-Phe.
Topics: Animals; Calcium; Cytoplasm; Eosinophils; Guinea Pigs; Kinetics; L-Lactate Dehydrogenase; Melitten; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Peritoneal Cavity; Peroxidases; Substance P; Superoxides; Thromboxane A2 | 1990 |
Comparative study on the innervation of nerves with calcitonin gene-related peptide, substance P and neurokinin A immunoreactivity in the walls of the cerebral arteries of small bats (Mammalia: Microchiroptera).
Topics: Acetylcholinesterase; Animals; Calcitonin Gene-Related Peptide; Cerebral Arteries; Chiroptera; Immunohistochemistry; Microscopy, Fluorescence; Neurokinin A; Neurons, Afferent; Species Specificity; Staining and Labeling; Substance P | 1990 |
Effect of substance P and neurokinin A on rat parietal cell function.
Topics: Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Cell Separation; Colforsin; Cyclic AMP; Female; Histamine; In Vitro Techniques; Kinetics; Neurokinin A; Parietal Cells, Gastric; Rats; Rats, Inbred Strains; Substance P | 1990 |
Substance P mediates synaptic transmission between rat myenteric neurones in cell culture.
Topics: Action Potentials; Animals; Cells, Cultured; Membrane Potentials; Myenteric Plexus; Neurokinin A; Neurons; Peptides; Potassium; Rats; Substance P; Synapses; Synaptic Transmission; Time Factors; Vasoactive Intestinal Peptide | 1990 |
Effects of intranigral substance P and neurokinin A on striatal dopamine release--I. Interactions with substance P antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Drug Interactions; Extracellular Space; Immunohistochemistry; Male; Neurokinin A; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
Effects of intranigral substance P and neurokinin A on striatal dopamine release--II. Interactions with bicuculline and naloxone.
Topics: Animals; Bicuculline; Corpus Striatum; Dopamine; Drug Combinations; Drug Interactions; Male; Naloxone; Neurokinin A; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
Intranigral substance P modulation of striatal dopamine: interaction with N-terminal and C-terminal substance P fragments.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Injections; Male; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1990 |
Neuropeptide control of rat gastric mucosal blood flow. Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Gastric Mucosa; Male; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Regional Blood Flow; Substance P; Vasoactive Intestinal Peptide | 1991 |
Occurrence, release, and effects of multiple tachykinins in cat colonic tissues and nerves.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Colon; Electric Stimulation; Eledoisin; Female; Ganglia, Autonomic; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Physalaemin; Physical Stimulation; Radioimmunoassay; Substance P; Tachykinins; Vasodilation | 1991 |
125I-neuropeptide Y binding activity of pig spleen cell membranes: effect of solubilisation.
Topics: Animals; Atrial Natriuretic Factor; Cell Membrane; Ligands; Neurokinin A; Neuropeptide Y; Receptors, Neuropeptide Y; Receptors, Neurotransmitter; Solubility; Spleen; Substance P; Swine; Vasoactive Intestinal Peptide | 1990 |
Neurokinin-immunoreactivity in human neuroblastomas. Evidence for selective expression of the preprotachykinin (PPT) II gene.
Topics: Chromatography, High Pressure Liquid; Gene Expression; Humans; Neuroblastoma; Neurokinin A; Neurokinin B; Protein Precursors; Radioimmunoassay; Substance P; Tachykinins | 1990 |
Enzyme immunoassay for tachykinin-like immunoreactivity in the guinea pig spinal cord.
Topics: Acetylcholinesterase; Animals; Capsaicin; Eledoisin; Guinea Pigs; Immunoenzyme Techniques; Kassinin; Male; Neurokinin A; Neurokinin B; Physalaemin; Potassium; Radioimmunoassay; Spinal Cord; Substance P; Tachykinins; Thiorphan | 1991 |
Tachykinins in the canine gastroesophageal junction.
Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Esophagogastric Junction; Esophagus; Gastric Mucosa; Immunohistochemistry; Manometry; Muscle Contraction; Neurokinin A; Neurokinin B; Neurons; Phentolamine; Radioimmunoassay; Substance P; Tachykinins; Tetrodotoxin | 1991 |
Neuropeptide release from isolated myenteric nerve endings derived from the guinea pig myenteric plexus.
Topics: Animals; Atropine; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Naloxone; Nerve Endings; Neurokinin A; Neuropeptides; Substance P; Xanthines | 1990 |
Mammalian regulatory peptide immunoreactivity in the trematode parasite Haplometra cylindracea and the lung of its frog host, Rana temporaria: comparative chromatographic characterisation using reverse-phase high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Gastrin-Releasing Peptide; Gastrins; Glucagon; Lung; Mammals; Neurokinin A; Neuropeptides; Peptides; Radioimmunoassay; Rana temporaria; Substance P; Trematoda | 1990 |
Airway effects of inhaled bradykinin, substance P, and neurokinin A in sheep.
Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Antigens, Helminth; Ascaris; Bradykinin; Bronchoconstriction; Bronchoconstrictor Agents; Carbachol; Dose-Response Relationship, Drug; Hypersensitivity; Neurokinin A; Sheep; Substance P | 1991 |
Priming effects of mammalian tachykinins on human neutrophils.
Topics: Dose-Response Relationship, Drug; Humans; Neurokinin A; Neurokinin B; Neutrophils; Platelet Activating Factor; Stimulation, Chemical; Substance P; Superoxides; Tachykinins | 1991 |
Striatonigral GABA, dynorphin, substance P and neurokinin A modulation of nigrostriatal dopamine release: evidence for direct regulatory mechanisms.
Topics: Animals; Corpus Striatum; Dialysis; Dopamine; Dynorphins; gamma-Aminobutyric Acid; Ibotenic Acid; Immunohistochemistry; Male; Neurokinin A; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; Reticular Formation; Substance P; Substantia Nigra; Tyrosine 3-Monooxygenase | 1990 |
Autoradiographic distribution of brain neurokinin-1/substance P receptors using a highly selective ligand [3H]-[Sar9,Met(O2)11]-substance P.
Topics: Animals; Autoradiography; Brain; Indicators and Reagents; Iodine Radioisotopes; Male; Neurokinin A; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Succinimides; Tritium | 1990 |
Tachykinins stimulate lyso-PAF:acetyl-CoA acetyltransferase activity in neutrophils.
Topics: Acetyltransferases; Animals; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Neurokinin B; Neutrophils; Rats; Rats, Inbred Strains; Stimulation, Chemical; Substance P; Tachykinins | 1990 |
Expression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymus.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Probes; Gene Expression; Humans; Immunohistochemistry; Infant; Male; Neurokinin A; Neuropeptide Y; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Substance P; Tachykinins; Thymus Gland; Tissue Distribution | 1990 |
Chemoreceptor responses to substance P, physalaemin and eledoisin: evidence for neurokinin-1 receptors in the cat carotid body.
Topics: Animals; Carotid Body; Cats; Chemoreceptor Cells; Dose-Response Relationship, Drug; Eledoisin; Female; Male; Neurokinin A; Physalaemin; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1990 |
Developmental changes in agonist-mediated colonic smooth muscle contraction in the rabbit.
Topics: Animals; Animals, Newborn; Atropine; Bethanechol; Bethanechol Compounds; Colon; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Potassium; Rabbits; Serotonin; Sincalide; Substance P | 1991 |
Effects of capsaicin on mechanical, cellular, and mediator responses to antigen in sensitized guinea pigs.
Topics: Animals; Antigens; Bronchoalveolar Lavage Fluid; Capsaicin; Guinea Pigs; Histamine; Immunization; Leukotrienes; Lung Compliance; Male; Neurokinin A; Ovalbumin; Prostaglandins; Substance P; Thromboxane B2 | 1991 |
Substance P and neurokinin A in human nasal mucosa.
Topics: Amino Acid Sequence; Autoradiography; Cells, Cultured; Chromatography, High Pressure Liquid; Glucosamine; Glycoconjugates; Humans; Immunohistochemistry; Lactoferrin; Molecular Sequence Data; Nasal Mucosa; Neurokinin A; Radioimmunoassay; Substance P; Tritium | 1991 |
Tachykinin-mediated modulation of the primary antibody response in rats: evidence for mediation by an NK-2 receptor.
Topics: Animals; Animals, Newborn; Antibody Formation; Capsaicin; Denervation; Female; Immune System; Lymph Nodes; Male; Neurokinin A; Peptide Fragments; Peripheral Nerves; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1991 |
Central action of tachykinins on activity of expiratory pumping muscles.
Topics: Animals; Cats; Dogs; Electromyography; Electrophysiology; Female; Injections; Male; Medulla Oblongata; Neurokinin A; Neurokinin B; Respiratory Muscles; Substance P; Tachykinins | 1990 |
Characterization of tachykinin receptors in urinary bladder from guinea pig.
Topics: Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1990 |
Projections of chemically-specified neurons in the guinea-pig colon.
Topics: Animals; Bombesin; Calbindins; Calcitonin Gene-Related Peptide; Colchicine; Colon; Denervation; Enkephalins; Female; Galanin; gamma-Aminobutyric Acid; Gastrin-Releasing Peptide; Guinea Pigs; Immunohistochemistry; Male; Myenteric Plexus; Neurokinin A; Neurons; Neuropeptide Y; Neuropeptides; Peptides; S100 Calcium Binding Protein G; Somatostatin; Substance P; Vasoactive Intestinal Peptide; Veratridine | 1990 |
Characterisation of the neurokinin receptors mediating contraction of isolated tracheal preparations from a variety of species.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P; Swine; Trachea | 1990 |
Substance P and substance K in the median eminence and paraventricular nucleus of the rat hypothalamus.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Median Eminence; Neurokinin A; Paraventricular Hypothalamic Nucleus; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Tissue Distribution | 1990 |
Tachykinin receptors in the circular muscle of the guinea-pig ileum.
Topics: Animals; Atropine; Carbachol; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1990 |
Novel selective agonists and antagonists confirm neurokinin NK1 receptors in guinea-pig vas deferens.
Topics: Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Vas Deferens | 1991 |
Inhibition of CRH-41 release by substance P, but not substance K, from the rat hypothalamus in vitro.
Topics: Animals; Corticotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Neurokinin A; Rats; Rats, Inbred Strains; Substance P | 1991 |
Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis.
Topics: Aged; Animals; Base Sequence; Cattle; Gene Expression Regulation; Humans; Immunohistochemistry; Leydig Cells; Male; Mice; Middle Aged; Molecular Sequence Data; Neurokinin A; Polymerase Chain Reaction; Protein Precursors; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Testis; Transcription, Genetic | 1991 |
Gene expression for peptides in neurons of the petrosal and nodose ganglia in rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Gene Expression; Glossopharyngeal Nerve; Immunohistochemistry; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Nodose Ganglion; Nucleic Acid Hybridization; Oligonucleotide Probes; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin; Substance P; Tachykinins | 1991 |
Evidence that calcitonin gene-related peptide contributes to the capsaicin-induced relaxation of guinea pig cerebral arteries.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Arteries; Guinea Pigs; Immunohistochemistry; Muscle Relaxation; Muscle, Smooth, Vascular; Neurokinin A; Substance P; Vasodilation | 1990 |
Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice.
Topics: Aggression; Animals; Behavior, Animal; Captopril; Dose-Response Relationship, Drug; Glycopeptides; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Neurokinin A; Substance P; Tachykinins | 1990 |
Tachykinin recovery during postmortem bronchoconstriction in guinea pig lungs.
Topics: Animals; Bronchi; In Vitro Techniques; Lung; Male; Neprilysin; Neurokinin A; Peptidyl-Dipeptidase A; Rats; Substance P | 1991 |
The central pressor actions of a novel tachykinin peptide, gamma-preprotachykinin-(72-92)-peptide amide.
Topics: Animals; Blood Pressure; Central Nervous System; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1991 |
In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.
Topics: Animals; Bronchi; Bronchoconstriction; Cerebral Cortex; Cricetinae; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Neurokinin A; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder; Vagus Nerve | 1991 |
Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor.
Topics: Animals; Aorta, Thoracic; Female; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1990 |
Opioid and neurokinin activities of substance P fragments and their analogs.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Neurokinin A; Neurokinin B; Peptide Fragments; Premedication; Substance P | 1991 |
Tachykinins (substance P, neurokinin A, neuropeptide K, and neurokinin B) in the cerebral circulation: vasomotor responses in vitro and in situ.
Topics: Animals; Arterioles; Basilar Artery; Binding, Competitive; Cats; Cerebral Arteries; Cerebrovascular Circulation; Endothelium, Vascular; Guinea Pigs; Humans; Neurokinin A; Neurokinin B; Neuropeptides; Pia Mater; Substance P; Tachykinins; Vasodilation | 1991 |
Effects of actinomycin D on airway constriction induced by tachykinins and capsaicin in guinea-pigs.
Topics: Airway Resistance; Animals; Capsaicin; Dactinomycin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine Antagonists; Male; Neurokinin A; Substance P; Tachykinins; Trachea | 1991 |
Skin reactivity to substance P, not to neurokinin A, is increased in allergic asthmatics.
Topics: Adult; Asthma; Erythema; Female; Humans; Male; Middle Aged; Neurokinin A; Peptide Fragments; Skin; Substance P | 1990 |
Substance P and substance K in the rat hypothalamus following monosodium glutamate lesions of the arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Chromatography, High Pressure Liquid; Corticotropin-Releasing Hormone; Dopamine; Hypothalamus; Neurokinin A; Radioimmunoassay; Rats; Rats, Inbred Strains; Sodium Glutamate; Substance P | 1991 |
Regulatory peptides and general neuroendocrine markers in human nasal mucosa, soft palate and larynx.
Topics: Biomarkers; Calcitonin Gene-Related Peptide; Endocrine Glands; Female; Humans; Immunohistochemistry; Larynx; Male; Nasal Mucosa; Neurokinin A; Palate, Soft; Peptides; Radioimmunoassay; Substance P | 1991 |
Tachykinin receptor cross-talk. Immunological cross-reactivity between the external domains of the substance K and substance P receptors.
Topics: Amino Acid Sequence; Animals; Calcium; Cells, Cultured; Cross Reactions; Epitopes; Humans; Lymphocytes; Molecular Sequence Data; Neurokinin A; Pancreas; Peptide Fragments; Protein Conformation; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Sequence Homology, Nucleic Acid; Signal Transduction; Structure-Activity Relationship; Substance P | 1991 |
The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis.
Topics: Angina Pectoris; Back Pain; Carcinoid Tumor; Eledoisin; Humans; Neurokinin A; Neurokinin B; Pericardial Effusion; Protein Binding; Saliva; Species Specificity; Substance P | 1991 |
Capsaicin and sensory neuropeptide stimulation of goblet cell secretion in guinea-pig trachea.
Topics: Anesthesia, General; Animals; Axons; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Exocrine Glands; Guinea Pigs; Male; Mucus; Neurokinin A; Neurokinin B; Neuropeptides; Substance P; Time Factors; Trachea | 1990 |
Effect of neurokinin A, substance P and calcitonin gene related peptide in peripheral hyperalgesia in the rat paw.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Inflammation; Male; Neurokinin A; Nociceptors; Rats; Rats, Inbred Strains; Substance P | 1991 |
Tachykinin receptors and noncholinergic bronchoconstriction in the guinea-pig isolated bronchi.
Topics: Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Guinea Pigs; Male; Neurokinin A; Neurons, Afferent; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Capsaicin-induced release of tachykinins: effects of enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Lung; Male; Neprilysin; Neurokinin A; Perfusion; Substance P | 1991 |
Specific neurokinin receptors mediate plasma extravasation in the rat knee joint.
Topics: Animals; Calcitonin Gene-Related Peptide; Cartilage, Articular; Injections; Knee Joint; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Neuropeptides of the primary sensory neurones in rat skin: an ontogenic study.
Topics: Aging; Animals; Calcitonin Gene-Related Peptide; Female; Male; Neurokinin A; Neurons, Afferent; Peptide PHI; Rats; Rats, Inbred Strains; Skin; Substance P | 1991 |
Substance P, neurokinin A and calcitonin gene-related peptide during development of the rat gastrointestinal tract.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Digestive System; Female; Gastric Mucosa; Intestine, Small; Male; Neurokinin A; Rats; Rats, Inbred Strains; Stomach; Substance P | 1991 |
Molecular heterogeneity of angiotensin converting enzyme in human cerebrospinal fluid.
Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Captopril; Chlorides; Chromatography, High Pressure Liquid; Enalapril; Enkephalin, Leucine; Humans; Molecular Sequence Data; Molecular Weight; Neurokinin A; Peptidyl-Dipeptidase A; Radioimmunoassay; Substance P | 1991 |
Tachykinin antagonists and capsaicin-induced contraction of the rat isolated urinary bladder: evidence for tachykinin-mediated cotransmission.
Topics: Adenosine Triphosphate; Animals; Bombesin; Capsaicin; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Rats; Rats, Inbred Strains; Receptors, Purinergic; Substance P; Synaptic Transmission; Tachykinins; Urinary Bladder | 1991 |
Comparison of the presence and actions of substance P and neurokinin A in guinea-pig taenia coli.
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Denervation; Female; Guinea Pigs; Immunohistochemistry; Male; Neurokinin A; Radioimmunoassay; Substance P | 1991 |
Effects of tachykinins on [3H]taurine release from human astrocytoma cells (U-373 MG).
Topics: Astrocytoma; Cell Line; Cyclic AMP; Humans; Isoproterenol; Kinetics; Neurokinin A; Substance P; Tachykinins; Taurine; Tritium | 1991 |
Neurokinin receptors in the rabbit iris sphincter characterised by novel agonist ligands.
Topics: Animals; In Vitro Techniques; Iris; Kinetics; Ligands; Male; Neurokinin A; Peptide Fragments; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Capsaicin-induced release of neurokinin A from muscle and mucosa of gastric corpus: correlation with capsaicin-evoked release of calcitonin gene-related peptide.
Topics: Animals; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Capsaicin; Gastric Mucosa; Immunoenzyme Techniques; Male; Muscles; Neurokinin A; Radioimmunoassay; Rats; Rats, Inbred Strains; Staining and Labeling; Stomach; Substance P | 1991 |
Effect of tachykinins in small human airways.
Topics: Bronchi; Bronchoconstriction; Carbachol; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Substance P; Thiorphan | 1991 |
5-HT3 receptor antagonists inhibit sensory neuropeptide release from the rat spinal cord.
Topics: Animals; Calcitonin Gene-Related Peptide; Granisetron; In Vitro Techniques; Indazoles; Indoles; Neurokinin A; Neurons, Afferent; Neuropeptides; Potassium; Rats; Rats, Inbred Strains; Serotonin Antagonists; Spinal Cord; Substance P; Tropisetron | 1990 |
Modulation of gastric contractions in response to tachykinins and bethanechol by extrinsic nerves.
Topics: Animals; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Female; Male; Muscle Contraction; Neurokinin A; Rats; Rats, Inbred Strains; Reflex; Stomach; Substance P; Tachykinins | 1991 |
Effects of dorsal rhizotomy on neurokinin receptor sub-types in the rat spinal cord: a quantitative autoradiographic study.
Topics: Analysis of Variance; Animals; Autoradiography; Eledoisin; Iodine Radioisotopes; Male; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Spinal Nerves; Substance P | 1991 |
Tachykinin receptors in the guinea-pig isolated bronchi.
Topics: Amino Acid Sequence; Animals; Bronchi; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Neurokinin A; Oligopeptides; Peptide Fragments; Phenoxybenzamine; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Functional interactions between capsaicin-sensitive and cholinergic nerves in the guinea pig bronchus.
Topics: Animals; Atropine; Bronchi; Bronchoconstriction; Capsaicin; Cholinergic Fibers; Electric Stimulation; Guinea Pigs; Male; Neurokinin A; Neurons, Afferent; Substance P; Vagus Nerve | 1991 |
Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin.
Topics: Animals; Cats; Electrophysiology; Iontophoresis; Neurokinin A; Neurons; Physalaemin; Spinal Cord; Substance P | 1991 |
Peptidase modulation of the pulmonary effects of tachykinins.
Topics: Animals; Captopril; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Neprilysin; Neurokinin A; Perfusion; Substance P; Thiorphan | 1991 |
Concentrations of neuropeptides substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid of the human temporomandibular joint. A correlation with symptoms, signs and arthroscopic fi
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Arthroscopy; Calcitonin Gene-Related Peptide; Cartilage, Articular; Female; Humans; Male; Middle Aged; Neurokinin A; Neuropeptide Y; Neuropeptides; Osteoarthritis; Substance P; Synovial Fluid; Synovitis; Temporomandibular Joint; Temporomandibular Joint Disorders; Vasoactive Intestinal Peptide | 1991 |
Neurokinin receptors antagonists: old and new.
Topics: Amino Acid Sequence; Analgesics; Animals; Dogs; Guinea Pigs; Kinetics; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Behavioural and biochemical responses following activation of midbrain dopamine pathways by receptor selective neurokinin agonists.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Dopamine; Haloperidol; Limbic System; Male; Mesencephalon; Molecular Sequence Data; Motor Activity; Neural Pathways; Neurokinin A; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1991 |
Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.
Topics: Administration, Cutaneous; Amino Acid Sequence; Animals; Bronchoconstriction; Capillary Permeability; Chromatography, High Pressure Liquid; Guinea Pigs; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Trachea | 1991 |
On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat.
Topics: Animals; Conditioning, Psychological; Electric Stimulation; Female; Injections, Spinal; Leg; Muscles; Neurokinin A; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P; Sural Nerve; Tachykinins | 1991 |
An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cats; Fluorescent Antibody Technique; Guinea Pigs; Humans; Neurokinin A; Neuropeptides; Oxidopamine; Rats; Rats, Inbred Strains; Skin; Substance P; Swine; Ubiquitin Thiolesterase | 1991 |
Pharmacological studies of tachykinin receptors mediating contraction of isolated airway smooth muscle.
Topics: Animals; Cricetinae; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Neurokinin A; Phenoxybenzamine; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1991 |
Developmental and hormonal regulation of the sex difference in preprotachykinin gene expression in rat anterior pituitaries.
Topics: Aging; Animals; Estradiol; Female; Gene Expression Regulation; Male; Neurokinin A; Orchiectomy; Pituitary Gland, Anterior; Protein Precursors; Rats; Reference Values; RNA, Messenger; Sex Characteristics; Substance P; Tachykinins; Testosterone; Thyroidectomy | 1991 |
Tachykinin-evoked release of neurotransmitters from isolated spinal cord of the newborn rat.
Topics: Acetylcholine; Animals; Animals, Newborn; gamma-Aminobutyric Acid; In Vitro Techniques; Neurokinin A; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tachykinins; Tetrodotoxin | 1991 |
Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation.
Topics: Animals; Electric Stimulation; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Transmission; Vas Deferens | 1991 |
Neurokinin innervation of the rat median raphe nucleus does not originate in the brain stem.
Topics: Animals; Axonal Transport; Brain Stem; Chromatography, High Pressure Liquid; Fluorescent Dyes; Male; Neurokinin A; Neurokinin B; Radioimmunoassay; Raphe Nuclei; Rats; Rats, Inbred Strains; Stilbamidines; Substance P | 1991 |
Neurokinin receptor-mediated regulation of [Ca]i and Ca-sensitive ion channels in mammalian colonic muscle.
Topics: Animals; Calcimycin; Calcium; Calcium Channels; Cells, Cultured; Colon; Membrane Potentials; Muscle, Smooth; Neurokinin A; Peptide Fragments; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1991 |
Endogenous 5-hydroxytryptamine modulates the release of tachykinins and calcitonin gene-related peptide from the rat spinal cord via 5-HT3 receptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Granisetron; In Vitro Techniques; Indazoles; Indoles; Neurokinin A; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Substance P; Tachykinins; Tropisetron | 1991 |
Characterization of bradykinin receptors in peripheral organs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Bradykinin; Cricetinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Jugular Veins; Leukotriene Antagonists; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Polyphloretin Phosphate; Prostaglandin Antagonists; Quinolines; Rabbits; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P; Trachea; Urinary Bladder | 1991 |
Involvement of substance P in hyperalgesia induced by intrathecal galanin.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Carrageenan; Galanin; Guinea Pigs; Ileum; In Vitro Techniques; Inflammation; Injections, Spinal; Male; Muscle, Smooth; Neurokinin A; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Substance P | 1991 |
Studies of reflexogenic effects of capsaicin and neuropeptides on neural afferents in the dog parietal pericardium.
Topics: Afferent Pathways; Animals; Arachidonic Acid; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Denervation; Dogs; Female; Heart Rate; Male; Neurokinin A; Neurokinin B; Neuropeptides; Pentolinium Tartrate; Pericardium; Propranolol; Substance P | 1991 |
Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat.
Topics: Acetylcholine; Animals; Animals, Newborn; Calcium; Dihydro-beta-Erythroidine; Edrophonium; Neurokinin A; Neurokinin B; Peptide Fragments; Physostigmine; Potassium; Rats; Rats, Inbred Strains; Secretory Rate; Spinal Cord; Stimulation, Chemical; Substance P; Tetrodotoxin; Veratridine | 1991 |
The effect of selective serotonergic neurotoxin treatment on tachykinin levels in the rat ventral spinal cord.
Topics: 5,7-Dihydroxytryptamine; Animals; Chromatography, High Pressure Liquid; Gene Expression Regulation; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P; Tachykinins | 1991 |
Neuropeptides in temporomandibular joints with rheumatoid arthritis: a clinical study.
Topics: Adult; Arthritis, Rheumatoid; Calcitonin Gene-Related Peptide; Female; Humans; Neurokinin A; Neuropeptide Y; Neuropeptides; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 1991 |
Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Neurokinin A; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Substance P; Tachykinins | 1991 |
Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs.
Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Kinetics; Lung; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Platelet Activating Factor; SRS-A; Substance P; Tachykinins | 1991 |
Resiniferatoxin-, capsaicin- and CGRP-evoked porcine coronary vasodilatation is independent of EDRF mechanisms but antagonized by CGRP(8-37).
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Dactinomycin; Diterpenes; Methylene Blue; Neurokinin A; Nitric Oxide; Peptide Fragments; Substance P; Vasodilation | 1991 |
NK2 tachykinin receptors and contraction of circular muscle of the human colon: characterization of the NK2 receptor subtype.
Topics: Aged; Amino Acid Sequence; Colon; Humans; In Vitro Techniques; Ligands; Middle Aged; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides; Protease Inhibitors; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Neurokinins produce selective venoconstriction via NK-3 receptors in the rat mesenteric vascular bed.
Topics: Acetylcholine; Animals; Bradykinin; Cholic Acids; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Perfusion; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Splanchnic Circulation; Structure-Activity Relationship; Substance P; Vasoconstriction; Vasodilation | 1991 |
Effects of tachykinins on myenteric neurones of the guinea-pig gastric corpus: involvement of NK-3 receptors.
Topics: Animals; Electrophysiology; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Neurokinin A; Neurokinin B; Neurons; Receptors, Neurotransmitter; Receptors, Tachykinin; Stomach; Substance P; Tachykinins | 1991 |
Ruthenium red and capsaicin induce a neurogenic inflammatory response in the rabbit eye: effects of omega-conotoxin GVIA and tetrodotoxin.
Topics: Animals; Aqueous Humor; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Capsaicin; Eye; Female; Inflammation; Intraocular Pressure; Male; Miosis; Neurokinin A; Nifedipine; omega-Conotoxin GVIA; Peptides, Cyclic; Rabbits; Ruthenium Red; Substance P; Tetrodotoxin | 1991 |
The presence of NK3 tachykinin receptors on rat uterus.
Topics: Animals; Binding, Competitive; Eledoisin; Female; Humans; In Vitro Techniques; Neurokinin A; Peptide Fragments; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Succinimides; Tachykinins; Uterine Contraction; Uterus | 1991 |
Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Bronchoconstriction; Dibenzazepines; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Neurokinin A; Phthalazines; Piperazines; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; SRS-A; Substance P | 1991 |
Differential effects of phosphoramidon on neurokinin A- and substance P-induced airflow obstruction and airway microvascular leakage in guinea-pig.
Topics: Administration, Inhalation; Airway Resistance; Animals; Bronchi; Capillary Permeability; Drug Synergism; Evans Blue; Exudates and Transudates; Glycopeptides; Guinea Pigs; In Vitro Techniques; Neprilysin; Neurokinin A; Propranolol; Protease Inhibitors; Serum Albumin; Substance P | 1991 |
[A pharmacological study of the participation of the peripheral endings of primary afferent neurons in the inflammatory response evoked by heat and mechanical noxious stimulation].
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Hot Temperature; Inflammation; Mice; Neurokinin A; Neurons, Afferent; Neuropeptides; Physical Stimulation; Rats; Substance P | 1990 |
[Immunohistochemical studies on the peptidergic nerve distribution in hard palate mucosa and gingiva of the rat].
Topics: Animals; Calcitonin Gene-Related Peptide; Epithelial Attachment; Fluorescent Antibody Technique; Gingiva; Immunohistochemistry; Mouth Mucosa; Nerve Fibers; Neurokinin A; Neuropeptide Y; Neuropeptides; Palate; Rats; Substance P; Vasoactive Intestinal Peptide | 1990 |
Modulation by adrenergic transmitters of the efferent function of capsaicin-sensitive nerves in cardiac tissue.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Guinea Pigs; Heart Atria; Heart Conduction System; Imidazoles; In Vitro Techniques; Male; Myocardial Contraction; Neurokinin A; Neurons, Afferent; Neuropeptide Y; Norepinephrine; Phenoxybenzamine; Substance P | 1991 |
Involvement of NK1 receptors and importance of the N-terminal sequence of substance P in the stimulation of protein secretion in rat parotid glands.
Topics: Amino Acid Sequence; Animals; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Parotid Gland; Proteins; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Stimulation, Chemical; Substance P | 1991 |
Nerve-induced tachykinin-mediated vasodilation in skeletal muscle is dependent on nitric oxide formation.
Topics: Animals; Arginine; Atropine; Bradykinin; Calcitonin Gene-Related Peptide; Dinoprostone; Dose-Response Relationship, Drug; Electric Stimulation; Hindlimb; Hyperemia; Muscles; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pancuronium; Rabbits; Substance P; Tachykinins; Vasodilation | 1991 |
Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra.
Topics: Animals; Dopamine; Iontophoresis; Kassinin; Male; Microinjections; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Peptides; Rats; Stimulation, Chemical; Substance P; Substantia Nigra; Synaptic Transmission | 1985 |
Demonstration and distribution of kassinin-like material (substance K) in the rat central nervous system.
Topics: Animals; Binding Sites; Brain; Chromatography, High Pressure Liquid; Immune Sera; Kassinin; Male; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P | 1985 |
Multiple tachykinin receptors in guinea pig brain. High densities of substance K (neurokinin A) binding sites in the substantia nigra.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Guinea Pigs; In Vitro Techniques; Male; Membranes; Nerve Tissue Proteins; Neurokinin A; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra | 1985 |
Substance K and substance P in the ventral tegmental area.
Topics: Animals; Autoradiography; Brain Mapping; Dopamine; Male; Motor Activity; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Substance P; Synaptic Transmission; Tegmentum Mesencephali | 1985 |
Neuropeptide K: a major tachykinin in plasma and tumor tissues from carcinoid patients.
Topics: Carcinoid Tumor; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Eledoisin; Humans; Immunoassay; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Substance P; Tachykinins | 1985 |
The regional distribution of kassinin-like immunoreactivity in central and peripheral tissues of the cat.
Topics: Adrenal Glands; Animals; Cats; Central Nervous System; Chromatography, High Pressure Liquid; Digestive System; Ganglia, Spinal; Ganglia, Sympathetic; Kassinin; Male; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Radioimmunoassay; Substance P; Tissue Distribution | 1985 |
Comparison of the effects of substance P and substance K on blood pressure, salivation and urinary bladder motility in urethane-anaesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Dose-Response Relationship, Drug; Male; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Salivation; Substance P; Urethane; Urinary Bladder | 1985 |
Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide.
Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Drug Synergism; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Neuropeptide Y; Oligopeptides; Rats; Substance P; Tachykinins | 1985 |
Tachykinin responses in the rat cingulate cortex: a comparison of the effects of iontophoretically applied substance P and neurokinin A.
Topics: Animals; Gyrus Cinguli; Iontophoresis; Male; Nerve Tissue Proteins; Neurokinin A; Neurons; Rats; Substance P; Tachykinins | 1985 |
Neurokinin A-like immunoreactivity in rat primary sensory neurons; coexistence with substance P.
Topics: Animals; Female; Ganglia, Spinal; Histocytochemistry; Immunochemistry; Nerve Tissue Proteins; Neurokinin A; Neurons; Rats; Rats, Inbred Strains; Skin; Spinal Cord; Substance P | 1985 |
In vivo and in vitro actions of mammalian tachykinins.
Topics: Animals; Blood Pressure; Eledoisin; Female; Guinea Pigs; Hindlimb; Histamine Release; Ileum; In Vitro Techniques; Jejunum; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rabbits; Rats; Rats, Inbred Strains; Salivation; Substance P; Tachykinins; Vas Deferens; Vasodilation | 1985 |
Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestines; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1985 |
Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat.
Topics: Anesthesia; Animals; Atropine; Blood Pressure; Gastrointestinal Motility; Guanethidine; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Substance P | 1985 |
Neurokinin A depolarizes neurons of the guinea pig inferior mesenteric ganglia.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Electric Conductivity; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Nerve Tissue Proteins; Neurokinin A; Potassium; Sodium; Stimulation, Chemical; Substance P | 1985 |
Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.
Topics: Animals; Atropine; Enkephalin, Methionine; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Naloxone; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Neurons; Neurotransmitter Agents; Oligopeptides; Peptide Fragments; Receptors, Muscarinic; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Substrate Specificity; Tachykinins | 1985 |
Regional distribution of substance P, neurokinin alpha and neurokinin beta in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection.
Topics: Animals; Central Nervous System; Ganglia, Spinal; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Nerve Roots; Spinal Nerves; Substance P | 1985 |
Substance K, a novel tachykinin injected bilaterally into the ventral tegmental area of rats increases behavioral response.
Topics: Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Rats, Inbred Strains; Substance P; Tegmentum Mesencephali; Time Factors | 1985 |
Substance K and substance P differentially modulate mesolimbic and mesocortical systems.
Topics: Animals; Cebus; Dopamine; Frontal Lobe; Immunoenzyme Techniques; Limbic System; Macaca; Male; Mesencephalon; Nerve Tissue Proteins; Neural Pathways; Neurokinin A; Neurotransmitter Agents; Rats; Substance P | 1985 |
Isolation and characterization of substance P, substance P 5-11, and substance K from two metastatic ileal carcinoids.
Topics: Amino Acid Sequence; Carcinoid Tumor; Chromatography, High Pressure Liquid; Humans; Ileal Neoplasms; Mass Spectrometry; Neoplasm Metastasis; Nerve Tissue Proteins; Neurokinin A; Peptide Fragments; Substance P; Tachykinins | 1985 |
Sensory and autonomic innervation of non-hairy and hairy human skin. An immunohistochemical study.
Topics: Autonomic Fibers, Postganglionic; Hair; Humans; Intermediate Filaments; Nerve Endings; Nerve Tissue Proteins; Neurokinin A; Neurons, Afferent; Neuropeptide Y; Phosphopyruvate Hydratase; Skin; Substance P; Tyrosine 3-Monooxygenase | 1986 |
Tachykinin receptors in smooth muscles: a study with agonists (substance P, neurokinin A) and antagonists.
Topics: Animals; Cricetinae; Eledoisin; Female; Guinea Pigs; In Vitro Techniques; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Physalaemin; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Species Specificity; Substance P | 1985 |
Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig.
Topics: Animals; Capsaicin; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Fluorescent Antibody Technique; Guinea Pigs; Nerve Tissue Proteins; Neurokinin A; Neurons, Afferent; Radioimmunoassay; Substance P; Tachykinins; Terminology as Topic; Tissue Distribution | 1985 |
The contractile activities of neurokinin A, B and related peptides on smooth muscles.
Topics: Amino Acid Sequence; Animals; Duodenum; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Structure-Activity Relationship; Substance P; Vas Deferens | 1986 |
Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder.
Topics: Animals; Autoradiography; Cerebral Cortex; Digestive System; Dose-Response Relationship, Drug; Eledoisin; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Mice; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Succinimides; Tachykinins; Urinary Bladder | 1986 |
Simultaneous release of several tachykinins and calcitonin gene-related peptide from rat spinal cord slices.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Chromatography, High Pressure Liquid; Female; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurokinin A; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1986 |
Tachykinin modulation of coronary blood flow.
Topics: Animals; Coronary Circulation; Female; Hemodynamics; Male; Myocardial Contraction; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Substance P; Swine; Tachykinins | 1986 |
Behavioral and neurochemical changes after intracisternal capsaicin treatment of the guinea pig.
Topics: Animals; Behavior, Animal; Capsaicin; Female; Guinea Pigs; Injections, Intraventricular; Male; Medulla Oblongata; Nasal Mucosa; Nerve Tissue Proteins; Neurokinin A; Substance P; Time Factors; Trigeminal Nucleus, Spinal | 1986 |
"Kassinin" in mammals: the newest tachykinins.
Topics: Amino Acid Sequence; Animals; Kassinin; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Radioimmunoassay; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Tissue Distribution | 1985 |
Distribution of substance K (neurokinin A) in the brain and peripheral tissues of rats.
Topics: Animals; Capsaicin; Central Nervous System; Chromatography, High Pressure Liquid; Female; Ileum; Male; Nerve Tissue Proteins; Neurokinin A; Radioimmunoassay; Rats; Rats, Inbred Strains; Submandibular Gland; Substance P; Vas Deferens | 1986 |
Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons.
Topics: Animals; Corpus Striatum; Haloperidol; Kinetics; Male; Nerve Tissue Proteins; Neurokinin A; Neurons; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger; Substance P; Substantia Nigra; Tachykinins | 1986 |
Tachykinin multiplicity in rat central nervous system as studied using antisera raised against substance P and neurokinin A.
Topics: Animals; Cross Reactions; Fluorescent Antibody Technique; Immunization; Intestinal Diseases; Male; Nerve Tissue Proteins; Neurokinin A; Peptides; Rabbits; Radioimmunoassay; Rats; Rupture; Spinal Cord; Substance P; Substantia Nigra; Tachykinins | 1986 |
The localization and characterization of substance P and substance K in striatonigral neurons.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Male; Nerve Tissue Proteins; Neurokinin A; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1986 |
Neuroleptic treatment induces region-specific changes in levels of neurokinin A and substance P in rat brain.
Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Haloperidol; Male; Nerve Tissue Proteins; Neurokinin A; Nucleus Accumbens; Organ Specificity; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Sulpiride | 1986 |
DNA synthesis induced by the neuropeptide substance K correlates to the level of myc-gene transcripts.
Topics: Animals; Cell Cycle; Cells, Cultured; Coturnix; Culture Media; Gene Expression Regulation; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Neurokinin A; Oncogene Proteins, Viral; Proto-Oncogene Proteins; Rats; Substance P; Tachykinins; Transcription, Genetic; Transfection | 1986 |
Activation of micturition reflex by substance P and substance K: indirect evidence for the existence of multiple tachykinin receptors in the rat urinary bladder.
Topics: Administration, Topical; Animals; Hydroxydopamines; Male; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Oxidopamine; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Spinal Cord; Substance P; Tetrodotoxin; Urinary Bladder; Urination | 1986 |
Motor effect of neurokinins on the rat duodenum: evidence for the involvement of substance K and substance P receptors.
Topics: Animals; Atropine; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Duodenum; Gastrointestinal Motility; Hexamethonium Compounds; Kassinin; Male; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tetrodotoxin | 1986 |
Histamine release and local responses of rat and human skin to substance P and other mammalian tachykinins.
Topics: Animals; Capillary Permeability; Histamine Release; Humans; In Vitro Techniques; Kassinin; Kinins; Mast Cells; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Rats, Inbred Strains; Skin; Skin Tests; Structure-Activity Relationship; Substance P | 1986 |
Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins.
Topics: Animals; Endothelium; In Vitro Techniques; Kassinin; Kinins; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Pulmonary Artery; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Substance P | 1986 |
Proteolytic inactivation of substance P and neurokinin A in the longitudinal muscle layer of guinea pig small intestine.
Topics: Aminopeptidases; Animals; Cell Fractionation; Cell Membrane; Endopeptidases; Epithelium; Guinea Pigs; Intestine, Small; Kinetics; Male; Microscopy, Electron; Muscle, Smooth; Neprilysin; Nerve Tissue Proteins; Neurokinin A; Peptide Fragments; Peptide Hydrolases; Substance P | 1986 |
Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Eledoisin; Injections, Spinal; Kinins; Male; Neurokinin A; Neuropeptides; Nociceptors; Physalaemin; Rats; Rats, Inbred Strains; Reflex; Substance P | 1986 |
Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin.
Topics: Animals; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Frontal Lobe; Male; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Stress, Psychological; Substance P; Tegmentum Mesencephali | 1986 |
[Effects of substance P, substance K and VIP on the mammalian iris sphincter muscles].
Topics: Animals; Cattle; Dogs; In Vitro Techniques; Iris; Neurokinin A; Neuropeptides; Oculomotor Muscles; Rabbits; Species Specificity; Substance P; Vasoactive Intestinal Peptide | 1986 |
Effects of neurokinin A, substance P and electrical stimulation on the rabbit iris sphincter muscle.
Topics: Amino Acid Sequence; Animals; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Rabbits; Substance P | 1986 |
Nociceptive behavior after intrathecal injections of substance P, neurokinin A and calcitonin gene-related peptide in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Female; Injections, Spinal; Mice; Neurokinin A; Neuropeptides; Pain; Peripheral Nerves; Spinal Cord; Substance P; Thermosensing | 1986 |
Differentiation of multiple neurokinin receptors in the guinea pig ileum.
Topics: Animals; Atropine; Binding, Competitive; Guinea Pigs; Ileum; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1986 |
Capsaicin induced release of multiple tachykinins (substance P, neurokinin A and eledoisin-like material) from guinea-pig spinal cord and ureter.
Topics: Animals; Capsaicin; Eledoisin; Female; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Proteinuria; Radioimmunoassay; Spinal Cord; Substance P; Tachykinins; Ureter | 1986 |
Dual capsaicin effects on ureteric motility: low dose inhibition mediated by calcitonin gene-related peptide and high dose stimulation by tachykinins?
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hemodynamics; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neuropeptides; Substance P; Tachykinins; Ureter | 1986 |
Conversion of neuropeptide K to neurokinin A and vesicular colocalization of neurokinin A and substance P in neurons of the guinea pig small intestine.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Guinea Pigs; Intestine, Small; Male; Myenteric Plexus; Neurokinin A; Neurons; Neuropeptides; Substance P; Synaptic Vesicles; Tachykinins; Tissue Distribution | 1987 |
A novel bioassay for the NK-2 neurokinin receptor: the guinea pig gallbladder.
Topics: Animals; Atropine; Biological Assay; Dose-Response Relationship, Drug; Eledoisin; Gallbladder; Guinea Pigs; Kassinin; Neurokinin A; Neuropeptides; Oligopeptides; Physalaemin; Proglumide; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Sincalide; Substance P; Tetrodotoxin | 1986 |
Levels of neurokinin A, neurokinin B and substance P in rabbit iris sphincter muscle.
Topics: Animals; Female; Iris; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Protein Precursors; Rabbits; RNA, Messenger; Substance P; Tachykinins | 1986 |
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.
Topics: Amino Acid Sequence; Animals; Base Sequence; Caudate Nucleus; Cloning, Molecular; DNA; DNA Restriction Enzymes; Neurokinin A; Neuropeptides; Nucleic Acid Hybridization; Protein Precursors; Putamen; Rats; Rats, Inbred Strains; RNA, Messenger; Substance P; Tachykinins | 1987 |
Effects of neurokinin A and calcitonin gene-related peptide on mucociliary activity in rabbit maxillary sinus.
Topics: Animals; Calcitonin Gene-Related Peptide; Cilia; Female; Male; Maxillary Sinus; Mucus; Neurokinin A; Neuropeptides; Rabbits; Substance P | 1986 |
Contractile effects of substance P and neurokinin A on the rat stomach in vivo and in vitro.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Female; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin | 1987 |
Regional distribution of neuropeptide K and other tachykinins (neurokinin A, neurokinin B and substance P) in rat central nervous system.
Topics: Animals; Antibodies; Antibody Specificity; Central Nervous System; Chromatography, High Pressure Liquid; Male; Neurokinin A; Neurokinin B; Neuropeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1986 |
Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways.
Topics: Airway Resistance; Bronchi; Chromatography, High Pressure Liquid; Humans; Neurokinin A; Neuropeptides; Pulmonary Artery; Radioimmunoassay; Substance P; Tachykinins; Vasodilator Agents | 1987 |
Substance P, neurokinin A, vasoactive intestinal polypeptide and gastrin releasing peptide in the intestine and pancreas of spontaneously obese-diabetic mice.
Topics: Animals; Diabetes Mellitus; Gastrin-Releasing Peptide; Insulin; Insulin Secretion; Intestines; Mice; Mice, Inbred C57BL; Mice, Obese; Mutation; Neurokinin A; Neuropeptides; Obesity; Pancreas; Peptides; Substance P; Vasoactive Intestinal Peptide | 1986 |
Characterization of tachykinin receptors in isolated basilar arteries of guinea-pig.
Topics: Animals; Basilar Artery; Dinoprost; Endothelium; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurokinin A; Neuropeptides; Prostaglandins F; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1987 |
Substance K and salivary secretion in the rat.
Topics: Amylases; Animals; Drug Synergism; Female; Neurokinin A; Neuropeptides; Parotid Gland; Rats; Rats, Inbred Strains; Saliva; Salivary Glands; Sublingual Gland; Submandibular Gland; Substance P; Vasoactive Intestinal Peptide | 1987 |
Pharmacological evidence for the possible coexistence of multiple receptor sites for mammalian tachykinins in rabbit iris sphincter smooth muscle.
Topics: Animals; Carbachol; Eledoisin; In Vitro Techniques; Iris; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1987 |
Trigeminal origin of beta-preprotachykinin products in feline pial blood vessels.
Topics: Animals; Arteries; Brain; Cats; Chromatography, High Pressure Liquid; Humans; Neurokinin A; Neuropeptides; Pia Mater; Radioimmunoassay; Substance P; Trigeminal Nerve | 1987 |
Action of the newly discovered mammalian tachykinins, substance K and neuromedin K, on gastroduodenal motility of anesthetized dogs.
Topics: Animals; Dogs; Duodenum; Eledoisin; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Physalaemin; Stomach; Substance P; Tachykinins | 1987 |
Neurokinin A and galanin in the thyroid gland: neuronal localization.
Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Cattle; Chickens; Denervation; Fluorescent Antibody Technique; Galanin; Ganglia, Sympathetic; Guinea Pigs; Histocytochemistry; Mice; Neurokinin A; Neurons; Neuropeptides; Peptides; Rats; Sheep; Substance P; Swine; Thyroid Gland | 1987 |
Further studies on the mechanisms of the tachykinin-induced activation of micturition reflex in rats: evidence for the involvement of the capsaicin-sensitive bladder mechanoreceptors.
Topics: Aging; Animals; Capsaicin; Diphenhydramine; Electric Stimulation; In Vitro Techniques; Indomethacin; Kassinin; Male; Mechanoreceptors; Neurokinin A; Neurokinin B; Neuropeptides; Oligopeptides; Rats; Rats, Inbred Strains; Substance P; Tetrodotoxin; Urinary Bladder; Urination | 1987 |
Effects of subchronic treatment with imipramine, zimelidine and alaproclate on regional tissue levels of substance P- and neurokinin A/neurokinin B-like immunoreactivity in the brain and spinal cord of the rat.
Topics: Alanine; Animals; Antidepressive Agents; Brain Chemistry; Central Nervous System; Imipramine; Immune Sera; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Zimeldine | 1987 |
Tachykinins in the central and peripheral nervous system of the ascidian Ciona intestinalis.
Topics: Chromatography, High Pressure Liquid; Ciona intestinalis; Histocytochemistry; Immunoenzyme Techniques; Nervous System; Neurokinin A; Neuropeptides; Radioimmunoassay; Substance P; Tachykinins; Tissue Distribution; Urochordata | 1987 |
Desensitization to substance P-induced vasodilation in vitro is not shared by endogenous tachykinin neurokinin A.
Topics: Animals; Atropine; Basilar Artery; Brain; Carotid Arteries; Chlorides; Dogs; In Vitro Techniques; Indomethacin; Inositol; Lithium; Lithium Chloride; Neurokinin A; Neuropeptides; Propranolol; Radioimmunoassay; Substance P; Tachykinins; Vasodilation | 1987 |
Microdialysis combined with a sensitive radioimmunoassay. A technique for studying in vivo release of neuropeptides.
Topics: Animals; Brain Chemistry; Dialysis; Male; Neurokinin A; Neuropeptides; Potassium Chloride; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P | 1987 |
Pharmacological analysis of 125I-Bolton and Hunter labelled eledoisin binding sites in rat spinal cord by quantitative autoradiography.
Topics: Animals; Autoradiography; Binding Sites; Cerebral Cortex; Eledoisin; Iodine Radioisotopes; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Spinal Cord; Substance P; Succinimides | 1987 |
Neuropeptides and secretion.
Topics: Amylases; Animals; Atropine; Calcitonin Gene-Related Peptide; Female; Male; Neurokinin A; Neuropeptides; Parasympathetic Nervous System; Parotid Gland; Rats; Rats, Inbred Strains; Saliva; Substance P; Vasoactive Intestinal Peptide | 1987 |
Comparison of the responses to the sensory neuropeptides, substance P, neurokinin A, neurokinin B and calcitonin gene-related peptide and to trigeminal nerve stimulation in the iris sphincter muscle of the rabbit.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Eledoisin; Female; Iris; Kinins; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Physalaemin; Potassium Chloride; Rabbits; Substance P; Trigeminal Nerve | 1987 |
Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract.
Topics: Animals; Capillary Permeability; Capsaicin; Electric Stimulation; Evans Blue; Ganglia; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Substance P; Urinary Tract | 1987 |
Substance P and calcitonin gene-related peptide: immunohistochemical localisation and microvascular effects in rabbit skeletal muscle.
Topics: Animals; Calcitonin Gene-Related Peptide; Histocytochemistry; Immunochemistry; Microcirculation; Muscles; Neurokinin A; Neuropeptides; Rabbits; Regional Blood Flow; Substance P | 1987 |
Neurokinin A in capsaicin-sensitive neurons of the guinea-pig inferior mesenteric ganglia: an additional putative mediator for the non-cholinergic excitatory postsynaptic potential.
Topics: Animals; Capsaicin; Chromatography, High Pressure Liquid; Electrophysiology; Female; Ganglia, Sympathetic; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Neurotransmitter Agents; Radioimmunoassay; Substance P; Synaptic Transmission | 1987 |
Several mediators appear to interact in neurogenic inflammation.
Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; In Vitro Techniques; Inflammation; Neurokinin A; Neurokinin B; Neuropeptides; Rabbits; Rats; Rats, Inbred Strains; Substance P; Vasodilation | 1987 |
Coexisting peptides in capsaicin-sensitive sensory neurons: release and actions in the respiratory tract of the guinea-pig.
Topics: Animals; Capsaicin; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Neurokinin A; Neuropeptides; Perfusion; Substance P; Trachea; Vasodilation | 1987 |
Selective agonists for substance P and neurokinin receptors.
Topics: Animals; Dogs; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Protein Conformation; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P | 1987 |
Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.
Topics: Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Hydroxydopamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Norepinephrine; Oxidopamine; Peptides; Rats; Rats, Inbred Strains; Reserpine; Substance P; Vas Deferens | 1987 |
Effects of substance P and neurokinin A (substance K) on motor behavior: unique effect of substance P attributable to its amino-terminal sequence.
Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Molecular Conformation; Molecular Weight; Neurokinin A; Neuropeptides; Peptide Fragments; Substance P; Tachykinins | 1987 |
Monoclonal antibodies to substance P: production, characterization of their fine specificities, and use in immunocytochemistry.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens; Female; Ganglia, Sympathetic; Hybridomas; Immunization; Immunoenzyme Techniques; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Radioimmunoassay; Rats; Spinal Cord; Substance P | 1987 |
Dopaminergic regulation of tachykinin metabolism in the striatonigral pathway.
Topics: Animals; Apomorphine; Brain Chemistry; Corpus Striatum; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Male; Neurokinin A; Neuropeptides; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Dopamine; RNA, Messenger; Substance P; Substantia Nigra; Tachykinins | 1987 |
Receptors for substance P on isolated intestinal smooth muscle cells of the guinea pig.
Topics: Animals; Binding, Competitive; Guinea Pigs; Intestinal Mucosa; Iodine Radioisotopes; Kinetics; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1987 |
Peptide receptors in the airways.
Topics: Animals; Bradykinin; Carotid Arteries; Dogs; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neuropeptides; Portal Vein; Rats; Receptors, Neurotransmitter; Substance P; Trachea | 1987 |
Comparison of substance K-like and substance P-like fibers and cells in the rat hippocampus.
Topics: Animals; Hippocampus; Immunohistochemistry; Male; Neurokinin A; Neuropeptides; Pyramidal Tracts; Rats; Rats, Inbred Strains; Substance P | 1987 |
Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responses.
Topics: Adult; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Interactions; Erythema; Female; Humans; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Skin; Skin Tests; Substance P; Vasodilator Agents | 1987 |
Subcellular distribution of mammalian tachykinins in rat basal ganglia.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Cell Fractionation; Chromatography, High Pressure Liquid; Dopamine; Female; Microscopy, Electron; Neurokinin A; Neurokinin B; Neuropeptides; Norepinephrine; Putamen; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Synaptic Vesicles; Synaptosomes; Tachykinins | 1988 |
Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epithelium; Ferrets; In Vitro Techniques; Metalloendopeptidases; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin B; Neuropeptides; Substance P; Tachykinins; Thiorphan; Tiopronin; Trachea | 1987 |
Characterization of substance P contractile activity on isolated guinea pig lung tissues.
Topics: Animals; Dose-Response Relationship, Drug; Glycopeptides; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Platelet Activating Factor; Prostaglandins; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Trachea | 1987 |
Effects of three mammalian tachykinins on single enteric neurons.
Topics: Animals; Electrophysiology; Guinea Pigs; Intestine, Small; Male; Myenteric Plexus; Neurokinin A; Neurokinin B; Neurons; Neuropeptides; Substance P | 1987 |
Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Lung; Male; Neurokinin A; Neuropeptides; Random Allocation; Substance P | 1987 |
Responses to antidromic trigeminal nerve stimulation, substance P, NKA, CGRP and capsaicin in the rat eye.
Topics: Animals; Aqueous Humor; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Male; Neurokinin A; Neuropeptides; Pupil; Rats; Rats, Inbred Strains; Substance P; Trigeminal Nerve | 1987 |
Huntington's disease: changes in tachykinin content in postmortem brains.
Topics: Animals; Brain; Humans; Huntington Disease; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Neuropeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1987 |
Striatal tachykinin biosynthesis: regulation of mRNA and peptide levels by dopamine agonists and antagonists.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Male; Neurokinin A; Neuropeptides; Protein Precursors; Rats; RNA, Messenger; Substance P; Tachykinins | 1987 |
Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum.
Topics: Animals; Corpus Striatum; Ibotenic Acid; Immunohistochemistry; Male; Neurokinin A; Neuropeptides; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1987 |
Substance P, nicotinic acetylcholine receptors and antinociception in the rat.
Topics: Analgesics; Animals; Hexamethonium Compounds; Injections, Intraventricular; Male; Mecamylamine; Naloxone; Neurokinin A; Neurokinin B; Neuropeptides; Nicotine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Cholinergic; Substance P | 1987 |
Effects of substance P and substance K on the growth of cultured keratinocytes.
Topics: Animals; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Epidermis; Keratins; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Substance P | 1988 |
RFLPs associated with the substance P-neurokinin A gene (NKNA).
Topics: Chromosomes, Human, Pair 7; Genes; Humans; Neurokinin A; Neuropeptides; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Substance P | 1988 |
Contractile response of the human isolated urinary bladder to neurokinins: involvement of NK-2 receptors.
Topics: Aged; Female; Humans; In Vitro Techniques; Isometric Contraction; Male; Middle Aged; Neurokinin A; Neurokinin B; Neuropeptides; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1988 |
Characterization of the effects produced by neurokinins and three agonists selective for neurokinin receptor subtypes in a spinal nociceptive reflex of the rat.
Topics: Adrenalectomy; Animals; Bradykinin; Dioxanes; Hot Temperature; Idazoxan; Male; Naloxone; Neurokinin A; Neurokinin B; Neuropeptides; Nociceptors; Pain Measurement; Peptide Fragments; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1988 |
Actions of neuropeptide K and calcitonin gene-related peptide on inferior mesenteric ganglion cells--tachykinin interactions with non-cholinergic potentials evoked by ureteric nerve stimulation.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Ganglia; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Mesentery; Neurokinin A; Neuropeptides; Peripheral Nerves; Receptors, Cholinergic; Substance P; Tachykinins | 1988 |
[Arg3]substance P and neurokinin A from chicken small intestine.
Topics: Amino Acids; Animals; Chickens; Chromatography, Gel; Chromatography, High Pressure Liquid; Immunochemistry; Intestine, Small; Neurokinin A; Neuropeptides; Substance P | 1988 |
Neurokinin A-like immunoreactivity in feline dental pulp: its distribution, origin and coexistence with substance P-like immunoreactivity.
Topics: Animals; Cats; Dental Pulp; Female; Fluorescent Antibody Technique; Immune Sera; Male; Nerve Fibers; Neurokinin A; Neuropeptides; Substance P | 1988 |
Tachykinin-induced phosphoinositide breakdown in airway smooth muscle and epithelium: relationship to contraction.
Topics: Animals; Epithelium; Guinea Pigs; In Vitro Techniques; Kinins; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Oligopeptides; Phosphatidylinositols; Substance P; Tachykinins; Trachea | 1988 |
Role of extracellular calcium in the effects of substance P and neurokinin A on guinea pig trachea and human bronchus.
Topics: Animals; Bronchi; Calcium; Guinea Pigs; Humans; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Nicardipine; Substance P; Theophylline; Trachea; Verapamil | 1988 |
Non-adrenergic, non-cholinergic salivary secretion in the ferret.
Topics: Animals; Atropine; Carnivora; Drug Interactions; Electric Stimulation; Female; Ferrets; Male; Methacholine Chloride; Methacholine Compounds; Neurokinin A; Neuropeptides; Saliva; Salivary Glands; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1988 |
Neurokinin A-(4-10): a potent bronchospastic agent virtually devoid of sialologic properties in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Bronchial Spasm; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Salivation; Substance P; Trachea | 1988 |
Pharmacological studies of grooming and scratching behavior elicited by spinal substance P and excitatory amino acids.
Topics: Amino Acids; Animals; Behavior, Animal; Grooming; Injections, Spinal; Neurokinin A; Neurokinin B; Neuropeptides; Serotonin; Serotonin Antagonists; Somatostatin; Spinal Cord; Substance P; Tryptamines | 1988 |
Neurokinins induce a relaxation of the rat duodenum "in vivo" by activating postganglionic sympathetic elements in prevertebral ganglia: involvement of an NK-2 type of neurokinin receptor.
Topics: Adrenalectomy; Animals; Duodenum; Guanethidine; Kassinin; Male; Muscle Contraction; Muscle Relaxation; Neurokinin A; Neurokinin B; Neuropeptides; Norepinephrine; Oligopeptides; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1988 |
Capsaicin-sensitive tachykinin-like immunoreactivity in the thymus of rats and guinea-pigs.
Topics: Animals; Capsaicin; Chromatography, High Pressure Liquid; Cricetinae; Eledoisin; Guinea Pigs; Immunologic Techniques; Mice; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Species Specificity; Substance P; Tachykinins; Thymus Gland | 1988 |
Evidence for the existence of three classes of neurokinin receptors in brain. Differential ontogeny of neurokinin-1, neurokinin-2 and neurokinin-3 binding sites in rat cerebral cortex.
Topics: Aging; Animals; Cerebral Cortex; Eledoisin; Female; Male; Neurokinin A; Neuropeptides; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1988 |
Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease.
Topics: Animals; Digestive System; Dogs; Gastrointestinal Diseases; Neurokinin A; Neurokinin B; Neurons; Neuropeptides; Substance P | 1988 |
Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons.
Topics: Animals; Cats; Corpus Striatum; Dendrites; Dopamine; Female; Glutamates; Glutamic Acid; Male; Nerve Endings; Neurokinin A; Neuropeptides; Riluzole; Substance P; Substantia Nigra; Thiazoles | 1988 |
Effect of neuropeptides on production of inflammatory cytokines by human monocytes.
Topics: Cells, Cultured; Humans; Interleukin-1; Interleukin-6; Interleukins; Kinetics; Monocytes; Neurokinin A; Neuropeptides; Protein Biosynthesis; Substance P; Tumor Necrosis Factor-alpha | 1988 |
[Quantification of neurokinin A neurokinin B, and substance P in the guinea pig lung by high performance liquid chromatography and subsequent radioimmunoassay].
Topics: Animals; Bronchi; Chromatography, High Pressure Liquid; Guinea Pigs; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neuropeptides; Radioimmunoassay; Substance P | 1988 |
NK-1 receptors mediate the tachykinin stimulation of salivary secretion: selective agonists provide further evidence.
Topics: Animals; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Salivation; Substance P; Tachykinins | 1988 |
Tachykinin-like immunoreactivity in the mammalian urinary bladder: correlation with the functions of the capsaicin-sensitive sensory nerves.
Topics: Animals; Capsaicin; Guinea Pigs; Male; Mice; Muscle Contraction; Neurokinin A; Neurons, Afferent; Neuropeptides; Phenoxybenzamine; Rats; Rats, Inbred Strains; Species Specificity; Substance P; Tachykinins; Urinary Bladder | 1988 |
Coupling between inositol phosphate formation and DNA synthesis in smooth muscle cells stimulated with neurokinin A.
Topics: Animals; Cells, Cultured; DNA; Epidermal Growth Factor; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Neurokinin A; Neuropeptides; Platelet-Derived Growth Factor; Rats; Substance P; Sugar Phosphates | 1988 |
Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Glossopharyngeal Nerve; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Nodose Ganglion; Rats; Rats, Inbred Strains; Substance P; Vagus Nerve; Vasoactive Intestinal Peptide | 1988 |
Comparison of the effects of epithelium removal and of an enkephalinase inhibitor on the neurokinin-induced contractions of guinea-pig isolated trachea.
Topics: Airway Resistance; Animals; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Neprilysin; Neurokinin A; Neurokinin B; Substance P; Tachykinins; Thiorphan; Trachea | 1988 |
Tachykinin involvement in parasympathetic nerve-evoked salivation of the ferret.
Topics: Amylases; Animals; Atropine; Female; Ferrets; Male; Methacholine Chloride; Methacholine Compounds; Neurokinin A; Parasympathetic Nervous System; Parotid Gland; Rats; Salivary Proteins and Peptides; Salivation; Submandibular Gland; Substance P; Tachykinins | 1988 |
Mammalian tachykinins modulate the nicotinic secretory response of cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Cells, Cultured; Neurokinin A; Neurokinin B; Nicotine; Receptors, Nicotinic; Recombinant Proteins; Substance P | 1988 |
Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.
Topics: Amino Acid Sequence; Animals; Arthritis; Cell Line; Cell-Free System; Interleukin-1; Leukemia P388; Leukemia, Experimental; Macrophages; Mice; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Substance P | 1988 |
Presynaptic transmitters and depolarizing influences regulate development of the substantia nigra in culture.
Topics: Animals; Blotting, Western; Culture Techniques; Dopamine; Immunohistochemistry; Membrane Potentials; Mice; Neurokinin A; Neurotransmitter Agents; Substance P; Substantia Nigra; Tyrosine 3-Monooxygenase; Veratridine | 1988 |
The mechanism of tachykinin-induced bronchoconstriction in the rat.
Topics: Airway Resistance; Animals; Bronchi; Dose-Response Relationship, Drug; Eledoisin; Kassinin; Lung Compliance; Male; Neurokinin A; Neurokinin B; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Vagotomy | 1988 |
Tachykinins enhance the depression of spinal nociceptive neurons caused by cutaneously applied vibration in the cat.
Topics: Action Potentials; Animals; Caffeine; Cats; In Vitro Techniques; Neural Inhibition; Neurokinin A; Nociceptors; Physalaemin; Spinal Cord; Substance P; Tachykinins; Vibration | 1988 |
Characterization of the effects of neurokinins on canine antral muscle.
Topics: Acetylcholine; Animals; Atropine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dogs; Female; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Pyloric Antrum; Reference Values; Substance P; Tetrodotoxin | 1988 |
Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation.
Topics: Animals; Bradykinin; Capsaicin; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Nervous System; Neurokinin A; Pulmonary Artery; Sensation; Substance P; Tachykinins; Trachea; Vagus Nerve | 1988 |
Temperature dependence of the effect of tachykinins on whole guinea-pig ileum in vitro.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Neurokinin A; Reference Values; Substance P; Temperature | 1988 |
Involvement of substance P in noncholinergic excitation of rabbit colonic muscle.
Topics: Acetylcholine; Animals; Atropine; Calcium; Colon; Electric Stimulation; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Rabbits; Substance P | 1989 |
Substance P, neurokinin A and neurokinin B in the ocular response to injury in the rabbit.
Topics: Animals; Electric Stimulation; Eye; Eye Injuries; Female; In Vitro Techniques; Infrared Rays; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Pupil; Rabbits; Radioimmunoassay; Substance P | 1988 |
Effects and interactions of sensory neuropeptides on airway microvascular leakage in guinea-pigs.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capillary Permeability; Guinea Pigs; Male; Neurokinin A; Neurokinin B; Neuropeptides; Receptors, Neurotransmitter; Receptors, Tachykinin; Respiratory System; Substance P | 1988 |
Intra-raphe neurokinin-induced hyperactivity: effects of 5,7-dihydroxytryptamine lesions.
Topics: 5,7-Dihydroxytryptamine; Action Potentials; Animals; Catecholamines; Dihydroxytryptamines; Male; Medial Forebrain Bundle; Motor Activity; Neural Pathways; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1989 |
Co-existence and origin of peptidergic and adrenergic nerves in the guinea pig uterus. Retrograde tracing and immunocytochemistry, effects of chemical sympathectomy, capsaicin treatment and pregnancy.
Topics: Adrenergic Fibers; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cervix Uteri; Female; Fluorescent Antibody Technique; Ganglia, Spinal; Guinea Pigs; Hydroxydopamines; Immunohistochemistry; Neurokinin A; Neuropeptide Y; Neuropeptides; Oxidopamine; Pregnancy; Substance P; Swine; Sympathectomy, Chemical; Uterus | 1988 |
Release of substance P- and calcitonin gene-related peptide-like immunoreactivity and motor response of the isolated guinea pig gallbladder to capsaicin.
Topics: Animals; Atropine; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Substance P | 1989 |
Stimulation of afferent fibres of the guinea-pig ureter evokes potentials in inferior mesenteric ganglion neurones.
Topics: Animals; Capsaicin; Female; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Nerve Fibers; Neurokinin A; Neurons; Neurons, Afferent; Substance P; Time Factors; Ureter | 1988 |
Lithium increases rat striatal beta- and gamma-preprotachykinin messenger RNAs.
Topics: Animals; Corpus Striatum; Haloperidol; Immunohistochemistry; Lithium; Male; Neurokinin A; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Substance P; Tachykinins | 1989 |
Tissue levels and in vivo release of tachykinins and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation.
Topics: Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Hydroxydopamines; Male; Neurokinin A; Oxidopamine; Parkinson Disease; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Tachykinins | 1989 |
Neurokinin-alpha injected into the ventral tegmental area elicits a dopamine-dependent behavioral activation in the rat.
Topics: Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Injections, Intraventricular; Male; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substance P; Tegmentum Mesencephali | 1988 |
Lack of desensitization to neurokinin A due to partial agonist property of this peptide at parotid substance P receptors.
Topics: Animals; Calcium; Cytoplasm; Fluorescent Dyes; Male; Neurokinin A; Parotid Gland; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1989 |
Prostacyclin release induced by neurokinins in cultured human endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Humans; Neurokinin A; Neurokinin B; Substance P | 1989 |
Selective agonists for receptors of substance P and related neurokinins.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Kinetics; Molecular Sequence Data; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1989 |
Facilitation by tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves.
Topics: Animals; Eledoisin; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Neurokinin A; Neurons; Parasympathetic Nervous System; Substance P; Synaptic Transmission; Tachykinins; Trachea | 1989 |
Interactions between the tachykinins and calcitonin gene-related peptide lead to the modulation of oedema formation and blood flow in rat skin.
Topics: Animals; Calcitonin Gene-Related Peptide; Drug Interactions; Edema; Histamine Antagonists; Male; Neurokinin A; Neurokinin B; Neuropeptides; Rats; Rats, Inbred Strains; Regional Blood Flow; Rheology; Serotonin Antagonists; Skin; Substance P; Tachykinins | 1989 |
Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2.
Topics: Action Potentials; Animals; Blood Pressure; Carotid Body; Cats; Chemoreceptor Cells; Female; Immunohistochemistry; Male; Neurokinin A; Oxygen Consumption; Substance P | 1989 |
Effect of a long-acting somatostatin analogue (octreotide) on circulating tachykinins and the pentagastrin-induced carcinoid flush.
Topics: Aged; Body Temperature; Carcinoid Tumor; Female; Flushing; Humans; Ileal Neoplasms; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neurokinin A; Octreotide; Pentagastrin; Radioimmunoassay; Substance P; Tachykinins | 1989 |
Subchronic haloperidol treatment decreases the in vivo release of tachykinins in rat substantia nigra.
Topics: Animals; Haloperidol; Male; Neurokinin A; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Tachykinins; Time Factors | 1989 |
Solution hybridization-nuclease protection assays for sensitive detection of differentially spliced substance P- and neurokinin A-encoding messenger ribonucleic acids.
Topics: Autoradiography; DNA; DNA Probes; Genes; Neurokinin A; Nucleic Acid Hybridization; Phosphorus Radioisotopes; Restriction Mapping; RNA Probes; RNA Splicing; RNA, Messenger; Substance P; Transcription, Genetic | 1989 |
Neurotensin, substance P, neurokinin-alpha, and enkephalin: injection into ventral tegmental area in the rat produces differential effects on operant responding.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Enkephalin, Methionine; Enkephalins; Injections; Male; Neurokinin A; Neurotensin; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance P; Tegmentum Mesencephali | 1989 |
Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P | 1989 |
Preincubation of human synovial cells with IL-1 modulates prostaglandin E2 release in response to bradykinin.
Topics: Adjuvants, Immunologic; Bradykinin; Calcimycin; Cells, Cultured; Dinoprost; Dinoprostone; Humans; Interleukin-1; Kinetics; Neurokinin A; Substance P; Synovial Membrane | 1989 |
Expression of substance P/neurokinin A-encoding preprotachykinin messenger ribonucleic acids in the rat enteric nervous system.
Topics: Animals; Ganglia; Gene Expression Regulation; Intestines; Male; Myenteric Plexus; Neurokinin A; Neurons; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA Probes; RNA, Messenger; Submucous Plexus; Substance P; Tachykinins | 1989 |
Label distribution after injection of labelled tachykinins into the rat lateral cerebroventricle.
Topics: Animals; Eledoisin; Injections, Intraventricular; Iodine Radioisotopes; Male; Neurokinin A; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1989 |
Neuropeptides in the human appendix. Distribution and motor effects.
Topics: Appendix; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Enkephalins; Galanin; Gastrin-Releasing Peptide; Humans; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Neuropeptide Y; Neuropeptides; Peptide PHI; Peptides; Protein Precursors; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1989 |
Substance p in the median eminence and pituitary of the rat: demonstration of immunoreactive fibers and specific binding sites.
Topics: Animals; Immunohistochemistry; Iodine Radioisotopes; Male; Median Eminence; Neurokinin A; Neurokinin B; Neurons; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1989 |
Tachykinins produce fast and slow depolarizations in sympathetic neurons of rat coeliac-superior mesenteric ganglia.
Topics: Animals; Ganglia, Sympathetic; In Vitro Techniques; Membrane Potentials; Mesentery; Neurokinin A; Neurokinin B; Rats; Substance P | 1989 |
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins.
Topics: Animals; Captopril; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Substance P; Tachykinins; Thiorphan | 1989 |
Effects of tachykinins and selective tachykinin receptor agonists on vascular permeability in the rat lower urinary tract: evidence for the involvement of NK-1 receptors.
Topics: Animals; Blood Pressure; Capillary Permeability; Cimetidine; Diphenhydramine; Kassinin; Male; Methysergide; Neurokinin A; Neurokinin B; Physalaemin; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Urinary Tract | 1989 |
[Innervation of the nasal mucosa of the guinea pig].
Topics: Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Guinea Pigs; Nasal Mucosa; Neurokinin A; Neuropeptides; Substance P; Vasoactive Intestinal Peptide | 1989 |
Capsaicin-induced vasodilatation of human coronary arteries in vitro is mediated by calcitonin gene-related peptide rather than substance P or neurokinin A.
Topics: Adult; Arteries; Biological Factors; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Female; Humans; Male; Muscle, Smooth, Vascular; Neurokinin A; Neuropeptides; Nitric Oxide; Somatostatin; Substance P; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Characterization of neurokinin effects and receptor selectivity in human isolated bronchi.
Topics: Acetylcholine; Bronchi; Epithelium; Glycopeptides; Humans; In Vitro Techniques; Muscle Contraction; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P | 1989 |
Classification of tachykinin receptors in muscularis mucosae of opossum oesophagus.
Topics: Animals; Carbachol; Electric Stimulation; Eledoisin; Esophagus; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Neurokinin A; Opossums; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1989 |
NK-1 receptor mediation of neurogenic plasma extravasation in rat skin.
Topics: Animals; Blister; Dose-Response Relationship, Drug; Electric Stimulation; Eledoisin; Kassinin; Male; Neurokinin A; Physalaemin; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1989 |
Cellular localization of substance P- and neurokinin A-encoding preprotachykinin mRNA in the female rat brain.
Topics: Animals; Brain; Brain Chemistry; Diencephalon; Female; Histocytochemistry; Immunohistochemistry; Mesencephalon; Neurokinin A; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA Probes; RNA, Messenger; Substance P; Tachykinins; Telencephalon | 1989 |
Regulation of epithelial transport in the jejunal mucosa of the guinea pig by neurokinins.
Topics: Animals; Atropine; Biological Transport; Calcitonin Gene-Related Peptide; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Neurokinin A; Neurokinin B; Substance P; Tachykinins; Tetrodotoxin | 1989 |
Contractile activity of the N-acylated C-terminal part of substance P7-11 in guinea pig trachea. Effect of epithelium removal.
Topics: Animals; Epithelium; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Substance P; Trachea | 1989 |
Regional differences in the motor and inflammatory responses to capsaicin in guinea pig airways. Correlation with content and release of substance P-like immunoreactivity.
Topics: Animals; Biomarkers; Blood Proteins; Bronchi; Calcitonin Gene-Related Peptide; Capsaicin; Carbachol; Guinea Pigs; Male; Muscle Contraction; Neurokinin A; Neurons, Afferent; Respiratory Muscles; Substance P; Trachea | 1989 |
The hamster isolated trachea: a new preparation for studying NK-2 receptors.
Topics: Animals; Atropine; Cricetinae; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Pyrilamine; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Thiorphan; Trachea | 1989 |
Capillary permeability induced by intravenous neurokinins. Receptor characterization and mechanism of action.
Topics: Animals; Blood Proteins; Capillary Permeability; Evans Blue; Female; Injections, Intravenous; Kinins; Male; Mast Cells; Neurokinin A; Neurokinin B; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Skin; Substance P | 1989 |
In vitro human polymorphonuclear leukocyte chemokinesis and human monocyte chemotaxis are different activities of aminoterminal and carboxyterminal substance P.
Topics: Calcitonin Gene-Related Peptide; Chemotaxis; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Monocytes; Neurokinin A; Neurokinin B; Neutrophils; Substance P | 1989 |
Vasopressin release induced by intracranial injection of tachykinins is due to activation of central neurokinin-3 receptors.
Topics: Animals; Blood Pressure; Injections; Male; Neurokinin A; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Vasopressins | 1989 |
Neurokinin A-induced bronchial hyperresponsiveness to methacholine in Japanese monkeys.
Topics: Airway Resistance; Animals; Bronchi; Dose-Response Relationship, Drug; Lung Compliance; Macaca; Male; Methacholine Chloride; Methacholine Compounds; Neurokinin A; Substance P; Time Factors | 1989 |
Identification of neurotransmitters regulating intestinal peristaltic reflex in humans.
Topics: Atropine; Ganglionic Blockers; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Humans; In Vitro Techniques; Jejunum; Motor Neurons; Neurokinin A; Neurotransmitter Agents; Peristalsis; Substance P; Tetrodotoxin; Vasoactive Intestinal Peptide | 1989 |
Neurohormonal peptides in the gut of the Atlantic hagfish (Myxine glutinosa) detected using antisera raised against mammalian regulatory peptides.
Topics: Animals; Cholecystokinin; Chromatography, Gel; Digestive System; Fishes; Gastrins; Glucagon; Hagfishes; Immune Sera; Immunohistochemistry; Neurokinin A; Peptides; Radioimmunoassay; Somatostatin; Substance P | 1989 |
Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain.
Topics: Animals; Brain; Electroconvulsive Therapy; Functional Laterality; Galanin; Male; Neurokinin A; Neuropeptides; Peptides; Rats; Rats, Inbred Strains; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1989 |
Tachykinins as transmitters of ascending contractile component of the peristaltic reflex.
Topics: Animals; Gastrointestinal Motility; Immune Sera; In Vitro Techniques; Neurokinin A; Peristalsis; Rats; Substance P; Tachykinins | 1989 |
Effect of sensory neuropeptides on canine bronchial and pulmonary vessels in vitro.
Topics: Animals; Bronchial Arteries; Calcitonin Gene-Related Peptide; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neuropeptides; Pulmonary Artery; Pulmonary Circulation; Pulmonary Veins; Substance P; Vasodilation | 1989 |
Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor.
Topics: Animals; Female; Ferrets; In Vitro Techniques; Male; Mucus; Muramidase; Muscle Tonus; Muscle, Smooth; Neprilysin; Neurokinin A; Receptors, Cell Surface; Serum Albumin, Bovine; Substance P; Thiorphan; Trachea | 1989 |
Effects of neurokinins on ion transport and sulfated macromolecule release in the isolated ferret trachea.
Topics: Amiloride; Animals; Biological Transport; Bumetanide; Chlorides; Electrodes; Ferrets; In Vitro Techniques; Macromolecular Substances; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Sodium; Substance P; Sulfates; Trachea | 1989 |
Substance P enhances the release of endogenous serotonin from rat ventral spinal cord.
Topics: Animals; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Potassium; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P | 1989 |
Characterization of the peripheral action of neurokinins and neurokinin receptor selective agonists on the rat cardiovascular system.
Topics: Animals; Cardiovascular System; Female; Injections, Intravenous; Male; Neurokinin A; Neurokinin B; Neurons, Afferent; Parasympathetic Nervous System; Peptide Fragments; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Substance P; Sympathetic Nervous System; Tachycardia | 1989 |
Effects of tachykinins on the secretion of fluid and glycoproteins from the submandibular glands of rat, mouse, hamster and guinea pig.
Topics: Animals; Cricetinae; Electrophoresis; Eledoisin; Glycoproteins; Guinea Pigs; Injections, Intravenous; Male; Mesocricetus; Mice; Neurokinin A; Physalaemin; Rats; Rats, Inbred Strains; Submandibular Gland; Substance P; Tachykinins | 1989 |
Central modulatory effects of tachykinin peptides on airway tone.
Topics: Airway Resistance; Animals; Cats; Female; Glycopeptides; Male; Medulla Oblongata; Neprilysin; Neurokinin A; Phrenic Nerve; Substance P; Thiorphan; Trachea | 1989 |
Effects of tachykinins on mucus secretion in human bronchi in vitro.
Topics: Adolescent; Adult; Aged; Bronchi; Child; Female; Glycopeptides; Humans; In Vitro Techniques; Male; Middle Aged; Mucus; Neprilysin; Neurokinin A; Neurokinin B; Substance P; Tachykinins | 1989 |
Tachykinin immunoreactivity in the parasitic flatworm Diclidophora merlangi and its fish host the whiting (Merlangius merlangus): radioimmunoassay and chromatographic characterisation using region-specific substance P and neurokinin A antisera.
Topics: Amino Acid Sequence; Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Fishes; Host-Parasite Interactions; Immune Sera; Molecular Sequence Data; Neurokinin A; Organ Specificity; Platyhelminths; Radioimmunoassay; Species Specificity; Substance P; Tachykinins | 1989 |
Peptide-containing nerves in the rat femoral artery and vein. An immunocytochemical and vasomotor study.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Femoral Artery; Femoral Vein; Immunohistochemistry; Neurokinin A; Neuropeptide Y; Norepinephrine; Peptide PHI; Potassium; Rats; Rats, Inbred Strains; Substance P; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide; Vasoconstriction | 1989 |
Effects of activators and antagonists of the neuropeptides substance P and substance K on cell proliferation in planarians.
Topics: Animals; Capsaicin; Cell Division; Epidermal Growth Factor; Models, Biological; Neurokinin A; Planarians; Substance P; Turbellaria | 1989 |
[Developmental changes in tachykinin response of the isolated rat duodenum].
Topics: Age Factors; Animals; Duodenum; Gastrointestinal Motility; In Vitro Techniques; Neurokinin A; Neurokinin B; Rats; Rats, Inbred Strains; Substance P | 1989 |
Effects of GABA and L-glutamic acid on the potassium-evoked in vitro release of substance P- and neurokinin A-like immunoreactivities are different in the rat striatum and substantia nigra.
Topics: Animals; Corpus Striatum; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurokinin A; Potassium; Potassium Chloride; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra | 1989 |
Expression and cellular localization of substance P/neurokinin A and neurokinin B mRNAs in the rat retina.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Autoradiography; Fluorescent Antibody Technique; Gene Expression; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Nucleic Acid Hybridization; Plasmids; Rats; Rats, Inbred Strains; Retina; RNA Probes; RNA, Antisense; RNA, Messenger; Substance P | 1989 |
Both neurokinin A and substance P bind to NK1 receptors in guinea-pig lung.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1989 |
Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices.
Topics: Animals; Brain; Cyclic AMP; Hydrolysis; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Phosphatidylinositols; Rats; Rats, Inbred Strains; Substance P | 1985 |
Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain.
Topics: Amino Acid Sequence; Animals; Brain; Isoenzymes; Lung; Models, Chemical; Nerve Tissue Proteins; Neurokinin A; Peptidyl-Dipeptidase A; Substance P; Substrate Specificity | 1985 |
Pharmacological characterisation of two tachykinin binding sites in the rat cerebral cortex.
Topics: Animals; Binding Sites; Cerebral Cortex; Eledoisin; In Vitro Techniques; Iodine Radioisotopes; Male; Nerve Tissue Proteins; Neurokinin A; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Succinimides; Synaptosomes | 1985 |
Regional distribution and in vivo release of tachykinin-like immunoreactivities in rat brain: evidence for regional differences in relative proportions of tachykinins.
Topics: Animals; Brain Chemistry; Corpus Striatum; Dialysis; Eledoisin; Kassinin; Male; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Physalaemin; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P; Tachykinins; Tissue Extracts | 1985 |
Neuropeptide K: isolation, structure and biological activities of a novel brain tachykinin.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Brain Chemistry; Chromatography, High Pressure Liquid; Gallbladder; Guinea Pigs; Kassinin; Muscle Contraction; Nerve Tissue Proteins; Neurokinin A; Oligopeptides; Substance P; Swine; Tachykinins | 1985 |
Substance P antagonists showing some selectivity for different receptor types.
Topics: Angiotensin II; Animals; Bradykinin; Cricetinae; Dogs; Guinea Pigs; In Vitro Techniques; Muscle, Smooth; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1985 |
Rat sensory ganglia incorporate radiolabelled amino acids into substance K (neurokinin alpha) in vitro.
Topics: Amino Acids; Animals; Ganglia, Spinal; In Vitro Techniques; Nerve Tissue Proteins; Neurokinin A; Rats; Substance P | 1984 |
Comparison of cardiovascular and bronchoconstrictor effects of substance P, substance K and other tachykinins.
Topics: Animals; Bombesin; Bronchi; Eledoisin; Guinea Pigs; Hemodynamics; In Vitro Techniques; Kassinin; Male; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Physalaemin; Respiration; Substance P; Time Factors | 1984 |
Release of substance P- and substance K-like immunoreactivities from the isolated perfused guinea-pig lung.
Topics: Animals; Capsaicin; Female; Guinea Pigs; In Vitro Techniques; Irritants; Lung; Male; Nerve Tissue Proteins; Neurokinin A; Perfusion; Radioimmunoassay; Substance P | 1984 |
The excitatory action of the newly-discovered mammalian tachykinins, neurokinin alpha and neurokinin beta, on neurons of the isolated spinal cord of the newborn rat.
Topics: Animals; Animals, Newborn; In Vitro Techniques; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptic Transmission | 1984 |
Regional distribution of substance P, neurokinin alpha and neurokinin beta in rat central nervous system.
Topics: Animals; Central Nervous System; Cerebellum; Cerebral Cortex; Corpus Striatum; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Substantia Nigra | 1984 |
Pharmacological characterization of novel mammalian tachykinins, neurokinin alpha and neurokinin beta.
Topics: Animals; Chemical Phenomena; Chemistry; Duodenum; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vas Deferens | 1984 |
Substance K: a novel mammalian tachykinin that differs from substance P in its pharmacological profile.
Topics: Animals; Blood Pressure; Cricetinae; Dose-Response Relationship, Drug; Duodenum; Guinea Pigs; Ileum; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Oligopeptides; Physalaemin; Rats; Rats, Inbred Strains; Substance P; Urinary Bladder; Vas Deferens | 1984 |
Comparative potencies of substance P, substance K and neuromedin K on brain substance P receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Male; Neurokinin A; Neurokinin B; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Neurokinin-1; Substance P | 1984 |
A pharmacological study with substance K: evidence for multiple types of tachykinin receptors.
Topics: Animals; Cricetinae; Eledoisin; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle, Smooth; Neurokinin A; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder; Vas Deferens | 1984 |
Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cross Reactions; Immune Sera; Male; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tissue Distribution | 1984 |
Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones.
Topics: Animals; Decerebrate State; Electrophysiology; Injections, Spinal; Male; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Neurokinin A; Neurokinin-1 Receptor Antagonists; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Sensory Thresholds; Stimulation, Chemical; Substance P | 1995 |
Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids.
Topics: Animals; Excitatory Amino Acids; Infusions, Intravenous; Iontophoresis; Macaca fascicularis; Male; Microdialysis; Neurokinin A; Neurons; Physical Stimulation; Skin Temperature; Spinothalamic Tracts; Stress, Mechanical; Substance P | 1995 |
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Parallel bioassay of PG-SPI, an amphibian acidic SP-like peptide, mammalian basic substance P, and neurokinins A and B on in vitro and in vivo test systems.
Topics: Amino Acid Sequence; Animals; Biological Assay; Biphenyl Compounds; Cricetinae; Evaluation Studies as Topic; Gastric Mucosa; Guinea Pigs; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Oligopeptides; Organ Culture Techniques; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Ranidae; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P | 1995 |
Characterization of receptors using cyanine 3-labeled neuropeptides.
Topics: Animals; Carbocyanines; Cell Line, Transformed; Cells, Cultured; Chromatography, High Pressure Liquid; Computer Systems; Endocytosis; Flow Cytometry; Fluorescent Dyes; Gastrin-Releasing Peptide; Guinea Pigs; Neurokinin A; Peptides; Rats; Receptors, Neuropeptide; Substance P; Transfection | 1995 |
Developmental changes of tachykinins in the hypothalamus and anterior pituitary of female Siberian hamsters from prepuberty to adulthood.
Topics: Aging; Animals; Body Weight; Circadian Rhythm; Cricetinae; Darkness; Female; Hypothalamus; Light; Neurokinin A; Organ Size; Ovary; Phodopus; Pituitary Gland, Anterior; Rats; Sexual Maturation; Species Specificity; Substance P; Uterus | 1995 |
Pharmacological characterization of the pressor response to tachykinins in isolated perfused rat kidney.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Kidney; Male; Molecular Sequence Data; Neurokinin A; Norepinephrine; Peptide Fragments; Perfusion; Phentolamine; Phenylephrine; Physalaemin; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins; Tyramine | 1993 |
Growth-regulatory effects of sensory neuropeptides, epidermal growth factor, insulin, and somatostatin on the non-transformed intestinal epithelial cell line IEC-6 and the colon cancer cell line HT 29.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelium; Gastrointestinal Hormones; Humans; Insulin; Intestinal Mucosa; Intestines; Neurokinin A; Neurons, Afferent; Neuropeptides; Peptide YY; Peptides; Rats; Somatostatin; Substance P; Transforming Growth Factor beta; Vasoactive Intestinal Peptide | 1993 |
Solution conformation study of substance P methyl ester and [Nle10]-neurokinin A (4-10) by NMR spectroscopy.
Topics: Amino Acid Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Protein Conformation; Solutions; Substance P | 1993 |
Selective agonists at NK3 tachykinin receptors inhibit alcohol intake in Sardinian alcohol-preferring rats.
Topics: Alcohol Drinking; Amino Acid Sequence; Animals; Drinking Behavior; Eating; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Water Deprivation | 1994 |
Development of substance P and neurokinin A immunoreactivity in ganglia supplying nerves to the submandibular glands of the rat.
Topics: Animals; Fluorescent Antibody Technique; Ganglia; Immunohistochemistry; Nerve Fibers; Neurokinin A; Neurons; Rats; Rats, Wistar; Submandibular Gland; Substance P; Superior Cervical Ganglion; Trigeminal Ganglion | 1993 |
Interaction between tachykinins and CGRP in human skin.
Topics: Adult; Calcitonin Gene-Related Peptide; Drug Combinations; Drug Interactions; Erythema; Female; Histamine; Humans; Injections, Intradermal; Male; Middle Aged; Neurokinin A; p-Methoxy-N-methylphenethylamine; Skin; Substance P; Tachykinins | 1993 |
A new selective bioassay for tachykinin NK3 receptors based on inositol monophosphate accumulation in the guinea pig ileum.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Inositol Phosphates; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Phospholipids; Receptors, Neurokinin-3; Stimulation, Chemical; Substance P; Tachykinins | 1993 |
Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.
Topics: Animals; Ferrets; Male; Neurokinin A; Piperidines; Stereoisomerism; Substance P; Vomiting | 1993 |
Neuropeptidergic innervation of equine synovial joints.
Topics: Animals; Female; Forelimb; Horses; Immunohistochemistry; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Substance P; Synovial Membrane | 1993 |
Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones.
Topics: Animals; Bronchi; Capsaicin; Electrophysiology; Ganglia, Parasympathetic; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Tachykinins | 1993 |
Effect of scyliorhinin I and synthetic scyliorhinin I derivatives at mammalian tachykinin NK1, NK2 and NK3 receptors.
Topics: Amino Acid Sequence; Animals; Cricetinae; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mesocricetus; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins | 1993 |
Repeated electroconvulsive stimuli: changes in neuropeptide Y, neurotensin and tachykinin concentrations in time.
Topics: Animals; Brain Chemistry; Electroshock; Male; Neurokinin A; Neuropeptide Y; Neurotensin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1994 |
Involvement of NK1 receptors in synaptic transmission in the guinea pig coeliac ganglion.
Topics: Animals; Electric Stimulation; Evoked Potentials; Female; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Receptors, Neurokinin-1; Substance P; Synapses; Synaptic Transmission; Tachykinins | 1993 |
Evolution of enhancer domains within the preprotachykinin promoter.
Topics: Animals; Base Sequence; Biological Evolution; Consensus Sequence; Enhancer Elements, Genetic; Gene Expression Regulation; HeLa Cells; Humans; Molecular Sequence Data; Neurokinin A; Promoter Regions, Genetic; Protein Precursors; Rats; Sequence Homology, Nucleic Acid; Substance P; Tachykinins; Transcription Factors | 1993 |
Effects of tachykinins on phosphoinositide metabolism in the hypothalamus: is the NK1 receptor involved?
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Hypothalamus; In Vitro Techniques; Inositol; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum.
Topics: Animals; Atropine; Calcium Channel Blockers; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth; Myenteric Plexus; Neurokinin A; omega-Conotoxin GVIA; Peptide Fragments; Peptides; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tetrodotoxin | 1994 |
Evidence for tachykinin NK-2 receptors in guinea-pig airways from binding and functional studies, using [125I]-[Lys5,Tyr(I2)7,MeLeu9,Nle10]-NKA(4-10).
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Bronchi; Drug Interactions; Female; Guinea Pigs; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuropeptides; Peptide Fragments; Protease Inhibitors; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Substance P; Tachykinins | 1994 |
In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains.
Topics: Airway Resistance; Animals; Atropine; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Captopril; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Methysergide; Neurokinin A; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Tachykinin; Serotonin; Substance P; Thiorphan | 1994 |
Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1994 |
Substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity (-LI) in rat knee joint synovial fluid during acute monoarthritis is not correlated with concentrations of neuropeptide-LI in cerebrospinal fluid and pl
Topics: Acute Disease; Animals; Arthritis; Calcitonin Gene-Related Peptide; Knee Joint; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Osmolar Concentration; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Synovial Fluid | 1994 |
Quantitation of N-terminally extended tachykinins in cerebrospinal fluid from healthy subjects.
Topics: Adult; Amino Acid Sequence; Chromatography, High Pressure Liquid; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Molecular Sequence Data; Neurokinin A; Neuropeptides; Radioimmunoassay; Substance P; Tachykinins | 1994 |
Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gerbillinae; Harderian Gland; Indoles; Injections, Intravenous; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P | 1994 |
Neurotensin modulates cholinergic and noncholinergic neurotransmission in guinea-pig main bronchi in vitro.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Bronchi; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Neurotensin; Parasympathetic Nervous System; Peptide Fragments; Pyrazoles; Quinolines; Receptors, Neurotensin; Substance P; Synaptic Transmission | 1994 |
A study of tachykinin-immunoreactivity in the cat visual cortex.
Topics: Animals; Antibodies, Monoclonal; Cats; Immunohistochemistry; Neurokinin A; Neurokinin B; Neurons; Presynaptic Terminals; Substance P; Tachykinins; Visual Cortex | 1994 |
Effect of capsaicin on distribution of binding sites for tachykinins and calcitonin gene-related peptide in rat urinary bladder: a quantitative autoradiographic study.
Topics: Animals; Autoradiography; Calcitonin Gene-Related Peptide; Capsaicin; Male; Neurokinin A; Protein Binding; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Tachykinin; Substance P; Tissue Distribution; Urinary Bladder | 1994 |
Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.
Topics: Adult; Amino Acid Sequence; Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Parasympathetic Nervous System; Peptide Fragments; Rabbits; Receptors, Tachykinin; Substance P; Sulfones; Synaptic Transmission; Tachykinins | 1994 |
Multiple types of tachykinin receptor mediate a slow excitation of rat spinal motoneurones in vitro.
Topics: Animals; Animals, Newborn; Female; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tetrodotoxin | 1994 |
Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems.
Topics: Animals; Binding Sites; Blood Vessels; Bronchi; Dipeptides; Glycopeptides; Guinea Pigs; Lung; Male; Neprilysin; Neurokinin A; Pulmonary Circulation; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins; Tritium | 1994 |
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins | 1994 |
NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.
Topics: Animals; Benzamides; Capillary Permeability; Evans Blue; Hindlimb; Indoles; Isoindoles; Joints; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synovial Fluid; Tachykinins | 1993 |
Different Ca2+ influx pathways mediate tachykinin receptor-induced contraction in circular muscle of guinea-pig colon.
Topics: Action Potentials; Animals; Calcium Channels; Colon; Electrophysiology; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Sulfones | 1994 |
A regional difference of the effect of tachykinin on cholinergic response evoked by electrical field stimulation in the rabbit airway.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Electric Stimulation; Endopeptidases; Glycopeptides; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Neprilysin; Neurokinin A; Parasympathetic Nervous System; Rabbits; Recombinant Proteins; Respiratory System; Substance P; Tachykinins | 1994 |
Tachykinin induced regulation of excitatory amino acid responses in the rat spinal cord in vitro.
Topics: Alkaloids; Animals; Animals, Newborn; Bradykinin; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; In Vitro Techniques; Kinetics; N-Methylaspartate; Neurokinin A; Protease Inhibitors; Protein Kinase C; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Staurosporine; Substance P; Time Factors | 1994 |
Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon.
Topics: Animals; Colon; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones | 1994 |
Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Substance P; Trachea | 1994 |
Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists.
Topics: Animals; Behavior, Animal; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
Tachykinin-mediated increase in motility acts independently of vasoactive intestinal polypeptide release in the canine ileum.
Topics: Animals; Dogs; Female; Gastrointestinal Motility; Ileum; Male; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vasoactive Intestinal Peptide | 1994 |
Effects of neuropeptide Y on lung vascular permeability in the pulmonary circulation of rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Neurotensin; Pulmonary Circulation; Rats; Rats, Wistar; Substance P | 1994 |
[Neurogenic inflammation and area of involvement of the facial nerve of the rat].
Topics: Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Electric Stimulation; Extravasation of Diagnostic and Therapeutic Materials; Facial Nerve; Neuritis; Neurokinin A; Rats; Rats, Wistar; Substance P; Vasodilation | 1994 |
The distribution and origin of nerve fibers immunoreactive for substance P and neurokinin A in the anterior buccal gland of the rat.
Topics: Animals; Cheek; Denervation; Female; Fluorescent Antibody Technique; Male; Mouth Mucosa; Nerve Fibers; Neurokinin A; Rats; Salivary Glands; Substance P; Superior Cervical Ganglion; Trigeminal Ganglion | 1994 |
Establishment of a cellular assay system for G protein-linked receptors: coupling of human NK2 and 5-HT2 receptors to phospholipase C activates a luciferase reporter gene.
Topics: Biological Assay; Cell Line; Gene Expression Regulation; Genes, Reporter; GTP-Binding Proteins; Humans; Intercellular Adhesion Molecule-1; Luciferases; Neurokinin A; Neurokinin B; Phosphatidylinositols; Receptors, Neurokinin-2; Receptors, Serotonin; Second Messenger Systems; Substance P; Transfection; Type C Phospholipases | 1993 |
Differential ability of tachykinin NK-1 and NK-2 agonists to produce scratching and grooming behaviours in mice.
Topics: Animals; Behavior, Animal; Brain; Grooming; Male; Mice; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1994 |
Physiological and pharmacological characterization of the spinal tachykinin NK2 receptor.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gerbillinae; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-2; Spinal Cord; Substance P; Tetrodotoxin | 1994 |
Epithelium modulates the kinetics of the response to substance P and its intrinsic activity in the guinea-pig trachea.
Topics: Animals; Carbachol; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Substance P; Thiorphan; Trachea | 1994 |
Immunoreactive substance P and neurokinin A in the hypothalamus and anterior pituitary gland of Siberian and Syrian hamsters and of rats.
Topics: Animals; Benzamides; Cricetinae; Female; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Hypothalamus; In Vitro Techniques; Male; Mesocricetus; Neurokinin A; Ovariectomy; Phodopus; Photoperiod; Piperidines; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1994 |
NK1 and NK2 receptors are similar in man and rabbit.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Humans; Iodine Radioisotopes; Kinetics; Muscle, Smooth, Vascular; Neurokinin A; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Recombinant Proteins; Substance P; Transfection; Tritium; Venae Cavae | 1994 |
Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Guinea Pigs; Indoles; Inflammation; Injections, Intradermal; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pyrilamine; Skin; Substance P; Tachykinins | 1994 |
A behaviorally active dose of lipopolysaccharide increases sensory neuropeptides levels in mouse spinal cord.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Feeding Behavior; Food; Immunoassay; Indomethacin; Lipopolysaccharides; Male; Mice; Neurokinin A; Neurons, Afferent; Neuropeptides; Spinal Cord; Substance P | 1994 |
Metabolism of substance P and neurokinin A by human vascular endothelium and smooth muscle.
Topics: Cells, Cultured; Endothelium, Vascular; Humans; Hydrolysis; Immunoelectrophoresis; Muscle, Smooth, Vascular; Neurokinin A; Substance P | 1994 |
Peptide-evoked release of amylase from isolated acini of the rat parotid gland.
Topics: Acetylcholine; Amylases; Animals; Calcitonin Gene-Related Peptide; Fluorescent Antibody Technique; Gastrin-Releasing Peptide; In Vitro Techniques; Male; Nerve Fibers; Neurokinin A; Neuropeptides; Parotid Gland; Peptides; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tachykinins; Vasoactive Intestinal Peptide | 1994 |
Substance P (SP) and neurokinin A (NKA) in developing submandibular glands of the rat.
Topics: Absorption; Animals; Female; Immunohistochemistry; Neurokinin A; Peroxidases; Pregnancy; Proteins; Rats; Rats, Wistar; Submandibular Gland; Substance P | 1994 |
Responses of lung parenchyma and airways to tachykinin peptides in piglets.
Topics: Airway Resistance; Animals; Blood Pressure; Female; Lung; Lung Compliance; Male; Neurokinin A; Pulmonary Alveoli; Respiration, Artificial; Substance P; Swine; Trachea | 1994 |
Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Chlorocebus aethiops; DNA Mutational Analysis; Humans; Kidney; Kinetics; Models, Structural; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Protein Structure, Secondary; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Transfection | 1994 |
Structural comparison of NK2 receptor agonists and antagonists.
Topics: Amino Acid Sequence; Drug Design; Models, Molecular; Molecular Sequence Data; Molecular Structure; Neurokinin A; Neurokinin B; Peptide Fragments; Protein Conformation; Receptors, Neurokinin-2; Substance P; Tachykinins; Thermodynamics | 1994 |
Multiple molecular forms of tachykinins in rat spinal cord: a study comparing different extraction methods.
Topics: Animals; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Immunochemistry; Male; Neurokinin A; Peptide Fragments; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tachykinins | 1994 |
Cyclic hexapeptide NK-2 antagonists.
Topics: Amino Acid Sequence; Binding, Competitive; Carbohydrate Sequence; Eledoisin; Glycopeptides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Neurokinin A; Oligopeptides; Peptides, Cyclic; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1994 |
Neurokinin A coexists with substance P and serotonin in ventral medullary spinally projecting neurons of the rat.
Topics: Animals; Central Nervous System; Immunohistochemistry; Male; Medulla Oblongata; Neurokinin A; Neurons; Pyramidal Tracts; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance P | 1994 |
Characterization of the substance P (NK-1) receptor in tunicamycin-treated transfected cells using a photoaffinity analogue of substance P.
Topics: Animals; CHO Cells; Cricetinae; Electrophoresis, Polyacrylamide Gel; Glycosylation; Light; Neurokinin A; Oligosaccharides; Receptors, Neurokinin-1; Substance P; Transfection; Tunicamycin | 1995 |
Tachykinin-induced contractions in the circular muscle of guinea pig ileum.
Topics: Animals; Atropine; Biphenyl Compounds; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptides, Cyclic; Rats; Structure-Activity Relationship; Substance P; Tachykinins; Tetrodotoxin | 1994 |
The effect of a single intraperitoneal dose of hrIL-1 alpha on substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity in cerebrospinal fluid, plasma and knee joint synovial fluid in the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Humans; Interleukin-1; Knee Joint; Male; Neurokinin A; Neuropeptide Y; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substance P; Synovial Fluid | 1994 |
Involvement of enzymatic degradation in the inactivation of tachykinin neurotransmitters in neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; Electrophysiology; Endopeptidases; In Vitro Techniques; Membranes; Motor Neurons; Naloxone; Neurokinin A; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Substance P; Synaptic Membranes | 1994 |
Non-specific inhibition of dopamine receptor agonist-induced behaviour by the tachykinin NK1 receptor antagonist CP-99,994 in guinea-pigs.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Dopamine Agonists; Grooming; Guinea Pigs; Haloperidol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oxazines; Piperidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1994 |
Tachykinins induce a [Ca2+]i rise in the acinar cells of feline tracheal submucosal gland.
Topics: Animals; Calcium; Cats; Exocrine Glands; Fura-2; Glycoproteins; In Vitro Techniques; Indicators and Reagents; Mucins; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-2; Substance P; Tachykinins; Trachea | 1994 |
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors.
Topics: Animals; Benzamides; Calcium; Calcium-Transporting ATPases; CHO Cells; Cricetinae; Cricetulus; Estrenes; Fura-2; Humans; Inositol Phosphates; Manganese; Neurokinin A; Peptide Fragments; Piperidines; Pyrrolidinones; Receptors, Neurokinin-3; Ryanodine; Second Messenger Systems; Structure-Activity Relationship; Substance P; Tachykinins; Terpenes; Thapsigargin; Type C Phospholipases | 1994 |
Substance P in intervertebral discs. Binding sites on vascular endothelium of the human annulus fibrosus.
Topics: Adult; Binding Sites; Endothelium, Vascular; Female; Guanylyl Imidodiphosphate; Humans; Intervertebral Disc; Iodine Radioisotopes; Male; Middle Aged; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Substance P | 1994 |
Neurokinin A mimics the slow excitatory postsynaptic current in submucous plexus neurons of the guinea-pig caecum.
Topics: Animals; Cecum; Electric Conductivity; Guinea Pigs; Ions; Membrane Potentials; Neurokinin A; Neurons; Submucous Plexus; Substance P; Synapses | 1994 |
In vitro effects of tachykinins on the smooth musculature of horse gut.
Topics: Analysis of Variance; Animals; Atropine; Colon; Dose-Response Relationship, Drug; Duodenum; Electrophysiology; Eledoisin; Horses; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Regression Analysis; Substance P; Tetrodotoxin | 1994 |
Effects of tachykinins on the splanchnic circulation: a comparison of the dog and rat.
Topics: Animals; Dogs; Female; Hemodynamics; Male; Mesenteric Artery, Superior; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Species Specificity; Splanchnic Circulation; Substance P; Tachykinins; Vascular Resistance; Vasodilation | 1994 |
Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis.
Topics: Calcitonin Gene-Related Peptide; Cell Division; Chemotaxis; Fibroblasts; Glycopeptides; Humans; Lung; Neprilysin; Neurokinin A; Neuropeptides; Substance P; Vasoactive Intestinal Peptide | 1995 |
Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder.
Topics: Animals; Cardiovascular Physiological Phenomena; Cats; Electric Stimulation; Female; Gallbladder; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 1995 |
Technique for assessment of leukocyte adherence to human umbilical vein endothelial cell monolayers.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Humans; Leukocyte Adherence Inhibition Test; Neurokinin A; Neutrophils; Reproducibility of Results; Substance P; Umbilical Veins | 1994 |
Isolation, identification, and culture of normal mouse colonic glia.
Topics: Animals; Astrocytes; Cell Separation; Cells, Cultured; Colon; Gene Expression; Immunohistochemistry; Intestinal Mucosa; Mice; Neuroglia; Neurokinin A; Substance P; Tachykinins | 1994 |
Effect of omega-conotoxin on cholinergic and tachykininergic excitatory neurotransmission to the circular muscle of the guinea-pig colon.
Topics: Acetylcholine; Animals; Atropine; Calcium Channel Blockers; Colon; Dipeptides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Methacholine Chloride; Motor Neurons; Neurokinin A; Oligopeptides; omega-Conotoxin GVIA; Peptides; Substance P; Tachykinins | 1994 |
Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Indoles; Isoindoles; Male; Methacholine Chloride; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
The regional distribution of neuropeptides in human skin as assessed by radioimmunoassay and high-performance liquid chromatography.
Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Neurokinin A; Neuropeptides; Peptide PHI; Radioimmunoassay; Skin; Substance P; Vasoactive Intestinal Peptide | 1994 |
The effects of intrathecal neuropeptide Y on the spinal nociceptive flexor reflex in rats with intact sciatic nerves and after peripheral axotomy.
Topics: Animals; Axons; Female; Injections, Spinal; Nerve Fibers; Neurokinin A; Neuropeptide Y; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Reflex, Monosynaptic; Regional Blood Flow; Sciatic Nerve; Spinal Cord; Substance P | 1994 |
Tachykinins contract trachea from Fischer 344 rats by interaction with a tachykinin NK1 receptor.
Topics: Animals; Carbachol; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Serotonin; Substance P; Tachykinins; Trachea | 1994 |
Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon.
Topics: Action Potentials; Animals; Atropine; Autonomic Nervous System; Colon; Dipeptides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neuromuscular Junction; Nifedipine; Oligopeptides; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission | 1994 |
Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.
Topics: Analysis of Variance; Animals; Cell Membrane; Corpus Striatum; Endocytosis; Endosomes; GTP-Binding Proteins; Immunohistochemistry; Kinetics; Male; Microscopy, Immunoelectron; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tissue Distribution | 1995 |
The human neostriatum shows compartmentalization of neuropeptide gene expression in dorsal and ventral regions: an in situ hybridization histochemical analysis.
Topics: Acetylcholinesterase; Adolescent; Adult; Cocaine; Enkephalins; Female; Gene Expression Regulation; Humans; In Situ Hybridization; Male; Middle Aged; Neostriatum; Neurokinin A; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger; Somatostatin; Substance P; Tachykinins | 1995 |
The action of substance P methyl ester on cochlear potentials in the guinea pig.
Topics: Action Potentials; Animals; Cochlea; Cochlear Microphonic Potentials; Dose-Response Relationship, Drug; Guinea Pigs; Neurokinin A; Neurokinin B; Peptide Fragments; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Pharmacology of tachykinin receptors on neurones in the ventral tegmental area of rat brain slices.
Topics: Action Potentials; Animals; Electrophysiology; In Vitro Techniques; Microelectrodes; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Ventral Tegmental Area | 1995 |
Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs.
Topics: Animals; Biphenyl Compounds; Bronchial Spasm; Capsaicin; Electric Stimulation; Guinea Pigs; Insufflation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vagus Nerve | 1995 |
Preprotachykinin-A gene expression occurs transiently in the developing rat endocrine pancreas and can be regulated in RINm5F cells.
Topics: Animals; Cell Line; Cyclic AMP; Female; Gene Expression Regulation, Developmental; Immunohistochemistry; Insulin; Islets of Langerhans; Neurokinin A; Pregnancy; Protein Kinase C; Protein Precursors; Rats; Receptors, Glucocorticoid; RNA, Messenger; Second Messenger Systems; Substance P; Tachykinins | 1995 |
Calcitonin gene-related peptide (CGRP) and its effects on protein release in vitro in the developing submandibular gland of the rat.
Topics: Aging; Animals; Calcitonin Gene-Related Peptide; Carbachol; Female; Immunohistochemistry; Male; Nerve Fibers; Neurokinin A; Neurons; Peroxidase; Proteins; Rats; Rats, Wistar; Submandibular Gland; Substance P; Superior Cervical Ganglion; Trigeminal Ganglion | 1995 |
Inhibition of neutral endopeptidase increases airway responsiveness to ACh in nonsensitized normal rats.
Topics: Acetylcholine; Administration, Inhalation; Animals; Bronchial Hyperreactivity; Capillary Permeability; Capsaicin; Carbachol; Glycopeptides; In Vitro Techniques; Male; Muscle, Smooth; Neprilysin; Neurokinin A; Protease Inhibitors; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Respiratory System; Substance P; Vagotomy | 1995 |
Neurokinin depletion attenuates pulmonary changes induced by antigen challenge in sensitized guinea pigs.
Topics: Animals; Antigens; Capsaicin; Guinea Pigs; Immunization; Immunoglobulin E; Immunoglobulin G; Lung; Male; Neurokinin A; Ovalbumin; Substance P | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.
Topics: Animals; Benzamides; Calcium; Cell Line; Kinetics; Mice; Neuroblastoma; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured | 1995 |
The peptidergic innervation of the human superficial temporal artery: immunohistochemistry, ultrastructure, and vasomotility.
Topics: Acetylcholinesterase; Animals; Antibodies; Calcitonin Gene-Related Peptide; Fluorescent Antibody Technique; Humans; Microscopy, Electron; Microscopy, Immunoelectron; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Fibers; Neurokinin A; Neuropeptide Y; Neuropeptides; Peptide PHI; Rabbits; Rats; Substance P; Tachykinins; Temporal Arteries; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1995 |
Co-variation of neuropeptide Y, calcitonin gene-related peptide, substance P and neurokinin A in joint fluid from patients with temporomandibular joint arthritis.
Topics: Adult; Aged; Arthritis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Calcitonin Gene-Related Peptide; Female; Humans; Male; Middle Aged; Neurokinin A; Neuropeptide Y; Osteoarthritis; Regression Analysis; Spondylitis, Ankylosing; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 1995 |
Neurokinin A and substance P vary independently in different regions of rat sensory neurons.
Topics: Animals; Ear; Ganglia, Spinal; Male; Neurokinin A; Neurons, Afferent; Presynaptic Terminals; Radioimmunoassay; Rats; Rats, Wistar; Spinal Cord; Substance P; Superior Cervical Ganglion; Trachea | 1995 |
Functional interaction between losartan and central tachykinin NK3 receptors in the conscious rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Drinking; Heart Rate; Imidazoles; Losartan; Male; Neurokinin A; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Tachykinins; Tetrazoles; Time Factors | 1995 |
Presence and actions of vasoactive intestinal peptide in the isolated rabbit heart.
Topics: Animals; Coronary Circulation; Ganglia; Heart; Immunohistochemistry; In Vitro Techniques; Male; Myocardium; Neurokinin A; Neurokinin B; Neurons; Rabbits; Substance P; Vasoactive Intestinal Peptide; Vasodilation | 1995 |
Passive immunization with an anti-substance P antibody prevents substance P- and neurokinin A-induced bronchospasm in anesthetized guinea-pigs.
Topics: Amino Acid Sequence; Anesthesia; Animals; Antibodies, Monoclonal; Antibody Specificity; Bronchial Spasm; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Guinea Pigs; Immunization, Passive; Methacholine Chloride; Mice; Molecular Sequence Data; Neurokinin A; Rats; Substance P | 1995 |
Tachykinin-induced nasal fluid secretion and plasma exudation in the rat: effects of peptidase inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Capillary Permeability; Captopril; Dose-Response Relationship, Drug; Glycopeptides; Male; Nasal Mucosa; Neprilysin; Neurokinin A; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1995 |
Effects of the tachykinin NK1 receptor antagonist, RP 67580, on central cardiovascular and behavioural effects of substance P, neurokinin A and neurokinin B.
Topics: Animals; Behavior, Animal; Cardiovascular System; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Substance P; Tachykinins | 1995 |
Identification of residues involved in ligand binding to the neurokinin-2 receptor.
Topics: Amino Acid Sequence; Benzamides; Binding Sites; DNA Mutational Analysis; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Phosphatidylinositols; Piperidines; Receptors, Neurokinin-2; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Substance P; Tachykinins | 1995 |
In-vitro exposure of guinea pig main bronchi to 2.5 ppm of nitrogen dioxide does not alter airway smooth muscle response.
Topics: Acetylcholine; Animals; Bronchi; Dose-Response Relationship, Drug; Electric Stimulation; Environmental Exposure; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nitrogen Dioxide; Substance P | 1995 |
Subtypes of tachykinin receptors on tonic and phasic neurones in coeliac ganglion of the guinea-pig.
Topics: Animals; Female; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Receptors, Tachykinin; Substance P | 1995 |
Sensory nerve- and neuropeptide-mediated relaxation responses in airways of Sprague-Dawley rats.
Topics: Animals; Bethanechol; Bronchodilator Agents; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Neurons, Afferent; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Tetrodotoxin; Trachea | 1995 |
Role of C fibers in physiological responses to ozone in rats.
Topics: Aerosols; Animals; Animals, Newborn; Body Temperature; Capsaicin; Female; Heart Rate; Lung Compliance; Male; Methacholine Chloride; Nerve Fibers; Neurokinin A; Ozone; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Substance P | 1995 |
Malignant carcinoid syndrome associated with cutaneous scleroderma.
Topics: Aged; Humans; Leg Dermatoses; Male; Malignant Carcinoid Syndrome; Neurokinin A; Paraneoplastic Syndromes; Scleroderma, Localized; Substance P | 1993 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Neurogenic inflammation in human airways: is it important?
Topics: Administration, Topical; Airway Resistance; Animals; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Humans; Nasal Mucosa; Neprilysin; Neurokinin A; Rhinitis, Allergic, Seasonal; Substance P | 1995 |
Effects of acute systemic treatment with the 5 HT-uptake blocker alaproclate on tissue levels and release of substance P in rat periaqueductal grey.
Topics: 5,7-Dihydroxytryptamine; Alanine; Animals; Cholecystokinin; Kinetics; Male; Morphine; Neurokinin A; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Substance P | 1995 |
Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Apamin; Arginine; Atropine; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Guanethidine; Guinea Pigs; Indomethacin; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Nifedipine; Nitroarginine; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Physalaemin; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Suramin; Thionucleotides | 1995 |
In vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect of vapreotide, an analgesic cyclic analog of somatostatin.
Topics: Acetylcholine; Analgesics; Animals; Binding, Competitive; Brain; Bronchi; Capillary Permeability; Duodenum; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Injections, Spinal; Male; Mice; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Somatostatin; Substance P | 1995 |
Tachykininergic slow depolarization of motoneurones evoked by descending fibres in the neonatal rat spinal cord.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ketanserin; Motor Neurons; Neurokinin A; Rats; Rats, Wistar; Spinal Nerve Roots; Substance P; Synaptic Transmission; Tachykinins; Thiorphan; Thyrotropin-Releasing Hormone | 1995 |
Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.
Topics: Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Ascending enteric reflex contraction: roles of acetylcholine and tachykinins in relation to distension and propagation of excitation.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Atropine; Cholinergic Antagonists; Female; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Ileum; In Vitro Techniques; Isometric Contraction; Isotonic Contraction; Jejunum; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Physalaemin; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Substance P; Synaptic Transmission; Tachykinins | 1993 |
Neurokinin-induced changes in pial artery diameter in the anaesthetized guinea-pig.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Physalaemin; Pia Mater; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Vasodilation | 1993 |
Attenuation of tachykinin-induced airflow obstruction and microvascular leakage in immature airways.
Topics: Aging; Airway Obstruction; Airway Resistance; Animals; Blood Pressure; Bronchoconstriction; Capillary Permeability; Evans Blue; Glycopeptides; Guinea Pigs; Lung; Male; Neprilysin; Neurokinin A; Pulmonary Ventilation; Substance P | 1993 |
Tachykinins potentiate N-methyl-D-aspartate responses in acutely isolated neurons from the dorsal horn.
Topics: Animals; Calcium; Cell Separation; Drug Synergism; N-Methylaspartate; Neurokinin A; Neurons; Osmolar Concentration; Phorbol 12,13-Dibutyrate; Rats; Spinal Cord; Substance P | 1993 |
The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea but not in the rat.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptosomes; Tachykinins; Type C Phospholipases | 1993 |
The role of neurokinin and N-methyl-D-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Biphenyl Compounds; Capsaicin; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P; Synapses; Synaptic Transmission | 1993 |
A selective tachykinin receptor agonist promotes differentiation but not survival of rat chromaffin cells in vitro.
Topics: Adrenal Glands; Animals; Cell Differentiation; Cell Survival; Chromaffin System; Fluorescent Antibody Technique; Hexamethonium Compounds; Immunohistochemistry; In Vitro Techniques; Nerve Growth Factors; Neurites; Neurokinin A; Peptide Fragments; Phenotype; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tyrosine 3-Monooxygenase | 1993 |
Electrophysiological effects of tachykinin analogues on ganglion cell activity in cyprinid fish retina.
Topics: Action Potentials; Animals; Cyprinidae; Eledoisin; Neurokinin A; Peptide Fragments; Physalaemin; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Tachykinin; Retinal Ganglion Cells; Species Specificity; Substance P; Tachykinins | 1993 |
Tachykinin control of ferret airways: mucus secretion, bronchoconstriction and receptor mapping.
Topics: Animals; Bronchoconstriction; Capsaicin; Ferrets; Male; Methacholine Chloride; Mucus; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Reproducibility of Results; Stimulation, Chemical; Substance P; Tachykinins; Trachea | 1993 |
Selective resistance of tachykinin-responsive cholinergic neurons in the quinolinic acid lesioned neostriatum.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Microinjections; Neostriatum; Neurokinin A; Neurons; Peptide Fragments; Potassium Chloride; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substance P | 1993 |
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.
Topics: Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Dipeptides; Electric Stimulation; Evans Blue; Exudates and Transudates; Guinea Pigs; Hypotension; Indoles; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Platelet Activating Factor; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Respiratory Mechanics; Smoking; Substance P; Vagus Nerve | 1993 |
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
Topics: Animals; Benzamides; Biphenyl Compounds; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Nociceptors; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P | 1993 |
Light- and electron-microscopic study of synaptic connections in the paracervical ganglion of the female rat: special reference to calcitonin gene-related peptide-, galanin- and tachykinin (substance P and neurokinin A)-immunoreactive nerve fibers and ter
Topics: Animals; Calcitonin Gene-Related Peptide; Female; Galanin; Ganglia, Sympathetic; Immunohistochemistry; Microscopy, Immunoelectron; Nerve Endings; Nerve Fibers; Neurokinin A; Peptides; Rats; Rats, Sprague-Dawley; Substance P; Synapses | 1993 |
Effect of frusemide on bradykinin- and capsaicin-induced contraction of the guinea-pig trachea.
Topics: Animals; Bradykinin; Bronchoconstriction; Capsaicin; Furosemide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Substance P; Trachea | 1993 |
Functional difference between SP and NKA: relaxation of gastric muscle by SP is mediated by VIP and NO.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitric Oxide; Nitroarginine; Peptide Fragments; Stomach; Substance P; Tachykinins; Tetrodotoxin; Vasoactive Intestinal Peptide | 1993 |
Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
Topics: Animals; Autonomic Nervous System; Benzamides; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Nerve Endings; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Agonists selective for tachykinin NK1 and NK3 receptors excite subpopulations of neurons in the rat medial habenula nucleus in vitro.
Topics: Animals; Electrophysiology; Extracellular Space; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Thalamic Nuclei | 1993 |
The rabbit iris sphincter contains NK1 and NK3 but not NK2 receptors: a study with selective agonists and antagonists.
Topics: Animals; Dactinomycin; Female; Iris; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1993 |
In vivo inhibition of the rat primary antibody response to antigenic stimulation by somatostatin.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antigens; Erythrocytes; Female; Male; Neurokinin A; Rats; Rats, Sprague-Dawley; Sheep; Somatostatin; Substance P | 1993 |
Distribution of neurokinin A in the cat diencephalon: an immunocytochemical study.
Topics: Animals; Cats; Diencephalon; Enkephalin, Methionine; Immunoenzyme Techniques; Immunohistochemistry; Male; Nerve Fibers; Neurokinin A; Neuropeptide Y; Neurotensin; Somatostatin; Somatostatin-28; Substance P | 1993 |
Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP.
Topics: Acetylcholine; Adult; Aged; Female; Glycopeptides; Histamine; Humans; Hypersensitivity; Immunization, Passive; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Phosphorylation; Substance P; Thermolysin; Vasoactive Intestinal Peptide | 1993 |
Selective neurokinin NK1 and NK2 receptor agonists infused in the substantia nigra of the rat increase vacuous chewing.
Topics: Animals; Dose-Response Relationship, Drug; Female; Mastication; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Substantia Nigra | 1993 |
Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscles; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1993 |
Receptor-mediated specific biological activity of a beta-amyloid protein fragment for NK-1 substance P receptors.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Low-dose intrathecal clonidine releases tachykinins in rat spinal cord.
Topics: Animals; Biphenyl Compounds; Clonidine; Decerebrate State; Hypnotics and Sedatives; Injections, Spinal; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P | 1993 |
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
Topics: Animals; Capillary Permeability; Capsaicin; Dipeptides; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Trachea | 1993 |
Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intra-Arterial; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Reflex; Substance P; Urinary Bladder; Urination | 1993 |
Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
Topics: Animals; Benzamides; Binding Sites; Biphenyl Compounds; Cells, Cultured; Epitopes; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Hypertonic Solutions; Neurokinin A; Neurons, Afferent; Piperidines; Platelet Activating Factor; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Tachykinin; Sodium Chloride; Stimulation, Chemical; Substance P; Trachea; Tracheal Diseases | 1993 |
High-affinity substance P binding sites of neurokinin-1 receptor type autoradiographically associated with vascular sinuses and high endothelial venules of human lymphoid tissues.
Topics: Autoradiography; Binding Sites; Blood Vessels; Humans; Lymph Nodes; Lymphoid Tissue; Neurokinin A; Palatine Tonsil; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spleen; Substance P; Succinimides | 1993 |
Differential release of endogenous 5-hydroxytryptamine, substance P, and neurokinin A from rat ventral spinal cord in response to electrical stimulation.
Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Electric Stimulation; In Vitro Techniques; Male; Neurokinin A; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Substance P | 1993 |
Impaired sensorineural function after allergen-induced mediator release.
Topics: Acetylcholine; Airway Resistance; Allergens; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Carbon Dioxide; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Male; Neurokinin A; Neurotransmitter Agents; Ovalbumin; Respiration Disorders; Substance P; Tidal Volume | 1993 |
Characterization of the binding of [125I-iodo-histidyl, methyl-Phe7] neurokinin B to the neurokinin-3 receptor.
Topics: Animals; Cell Membrane; Cells, Cultured; Cerebral Cortex; CHO Cells; Cricetinae; Humans; Neurokinin A; Neurokinin B; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins; Substance P | 1993 |
Substance P and neurokinin A are colocalized in the central chemosensory pathway of the male golden hamster.
Topics: Amygdala; Animals; Chemoreceptor Cells; Cricetinae; Fluorescent Antibody Technique; Immunoenzyme Techniques; Male; Mesocricetus; Neurokinin A; Preoptic Area; Sexual Behavior, Animal; Substance P; Thalamus | 1993 |
The influence of neurokinins and calcitonin gene-related peptide on cerebral blood flow in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Cerebrovascular Circulation; Guinea Pigs; Kinetics; Male; Neurokinin A; Peptide Fragments; Substance P | 1993 |
Nerve growth factor (NGF) regulates tachykinin gene expression and biosynthesis in rat sensory neurons during early postnatal development.
Topics: Animals; Animals, Newborn; Blotting, Northern; Ganglia, Spinal; Gene Expression Regulation; Nerve Growth Factors; Neurokinin A; Neurons, Afferent; Protein Precursors; Rats; RNA, Messenger; Substance P; Tachykinins; Trigeminal Ganglion | 1993 |
Tachykinin-1 gene products in porcine ocular tissues: evidence for transcriptional and post-translational regulation.
Topics: Animals; Chromatography, High Pressure Liquid; Gene Expression Regulation; Neurokinin A; Ocular Physiological Phenomena; Protein Processing, Post-Translational; Radioimmunoassay; Retina; Substance P; Swine; Tachykinins; Transcription, Genetic | 1993 |
Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists.
Topics: Animals; Ferrets; Macromolecular Substances; Male; Muscle Contraction; Neurokinin A; Peptides; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins; Trachea | 1993 |
NK1 receptors mediate tachykinin-induced increase in microvascular clearance in hamster cheek pouch.
Topics: Animals; Biphenyl Compounds; Capsaicin; Cheek; Cricetinae; Macromolecular Substances; Male; Mesocricetus; Microcirculation; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tachykinins | 1993 |
Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior.
Topics: Amygdala; Animals; Brain Mapping; Copulation; Dose-Response Relationship, Drug; Ejaculation; Male; Neural Pathways; Neurokinin A; Neurokinin B; Peptide Fragments; Preoptic Area; Rats; Reaction Time; Sexual Behavior, Animal; Substance P; Tachykinins | 1993 |
Immunohistochemical distribution, biochemical characterization, and biological action of tachykinins in the frog adrenal gland.
Topics: 6-Ketoprostaglandin F1 alpha; Adrenal Cortex Hormones; Adrenal Glands; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Dinoprostone; Fluorescent Antibody Technique; Immunohistochemistry; Male; Microscopy, Immunoelectron; Molecular Sequence Data; Neurokinin A; Neurokinin B; Rana ridibunda; Substance P; Tachykinins; Tissue Distribution | 1993 |
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
Topics: Adolescent; Adult; Aged; Atropine; Benzamides; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Esophagus; Glycopeptides; Humans; Isometric Contraction; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin | 1993 |
Characterization of neurokinin binding sites in rat brain membranes using highly selective ligands.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain Chemistry; Eledoisin; Female; Ligands; Membrane Proteins; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
A role for the C-terminal fragment of substance P,SP7-11 in the pathogenesis of arthritis.
Topics: Amino Acid Sequence; Animals; Arthritis; Cartilage, Articular; Cattle; Collagenases; Dinoprostone; Kinetics; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Substance P | 1993 |
Involvement of substance P present in small-diameter afferent fibers in microcirculatory hemodynamics of the rat hind instep.
Topics: Afferent Pathways; Animals; Bradykinin; Dose-Response Relationship, Drug; Hindlimb; Male; Microcirculation; Muscle, Smooth, Vascular; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Skin; Substance P | 1993 |
Neurokinin A, but not neurokinin B and substance P, induces codeine-resistant coughs in awake guinea-pigs.
Topics: Animals; Capsaicin; Codeine; Cough; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Male; Neurokinin A; Neurokinin B; Substance P | 1993 |
Multiple actions of substance P and other tachykinins on sympathetic neurons in rat prevertebral ganglia.
Topics: Action Potentials; Animals; Electrophysiology; Evoked Potentials; Ganglia, Sympathetic; In Vitro Techniques; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Rats; Receptors, Tachykinin; Substance P; Time Factors | 1993 |
Regional differences in contractile responses to tachykinin agonists and to electrical field stimulation are dependent on distribution of proteinase activity.
Topics: Animals; Bronchi; Electric Stimulation; Endopeptidases; Glycopeptides; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Protease Inhibitors; Rabbits; Substance P; Trachea | 1993 |
Does substance P release mediate NANC nerve-mediated responses to field stimulation and ligands, in the rabbit isolated sphincter pupillae?
Topics: Animals; Bradykinin; Capsaicin; Electric Stimulation; Isometric Contraction; Male; Muscle, Smooth; Neurokinin A; Neurons, Afferent; Physalaemin; Pupil; Rabbits; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins | 1993 |
Pharmacological analysis of receptors involved in tachykininergic contraction induced by electrical transmural stimulation in the rabbit iris sphincter muscle.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; In Vitro Techniques; Iris; Isometric Contraction; Male; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Rabbits; Receptors, Neurokinin-1; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1993 |
Functional characterization of neurokinin receptors with agonists and antagonists.
Topics: Amino Acid Sequence; Animals; Biphenyl Compounds; Guinea Pigs; Molecular Sequence Data; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Portal Vein; Rabbits; Rats; Receptors, Tachykinin; Structure-Activity Relationship; Substance P; Tachykinins; Trachea; Venae Cavae | 1993 |
Role of NK-1 receptor in central cardiovascular regulation in rats: studies on a novel non-peptide antagonist, CP-96,345, of substance P NK-1 receptor.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Heart Rate; Hypnotics and Sedatives; Injections, Intraventricular; Male; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, Neurokinin-1; Substance P; Tachykinins; Vas Deferens | 1993 |
Evidence for NK-1 receptor subtypes from in vivo bronchopulmonary and cardiovascular studies.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Bronchi; Bronchoconstriction; Guinea Pigs; Indoles; Isoindoles; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
Blockade of cutaneous nerve-evoked responses by GR71251 in the isolated spinal cord preparation of newborn rat.
Topics: Animals; Animals, Newborn; Bombesin; Electric Stimulation; Evoked Potentials; Gastrin-Releasing Peptide; In Vitro Techniques; Neurokinin A; Neurokinin B; Peptides; Peripheral Nerves; Rats; Rats, Wistar; Skin; Spinal Cord; Substance P | 1993 |
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder | 1993 |
Novel substance P analogues inhibit circular muscle contraction of guinea pig ileum and depolarization of new born rat spinal cord induced by substance P.
Topics: Animals; Animals, Newborn; Guinea Pigs; Ileum; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Neurokinin A; Rats; Spinal Cord; Structure-Activity Relationship; Substance P | 1993 |
The pharmacological properties of FK888, a novel dipeptide NK1 antagonist.
Topics: Animals; Bronchoconstriction; Capsaicin; Cell Membrane; Dipeptides; Edema; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Indoles; Kinetics; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-1; Substance P | 1993 |
N-terminally extended tachykinins in human cerebrospinal fluid.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Humans; Neurokinin A; Radioimmunoassay; Rats; Spinal Cord; Substance P; Tachykinins; Trypsin | 1993 |
The mechanism of central pressor actions of tachykinin NK-3 receptor in the paraventricular nucleus of the hypothalamus in rats.
Topics: Animals; Blood Pressure; Models, Biological; Neurokinin A; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Receptors, Neurokinin-3; Substance P | 1993 |
In vivo characterization of tachykinin receptors responsible for the central cardiovascular effects of substance P and neurokinin A.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Blood Pressure; Heart Rate; Neurokinin A; Oligopeptides; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereotyped Behavior; Substance P | 1993 |
Tachykinins depress a calcium-dependent potassium conductance in sympathetic preganglionic neurons.
Topics: Action Potentials; Animals; Calcium; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Neurokinin A; Neurons; Potassium Channels; Spinal Cord; Substance P | 1993 |
Neurokinin-1, -2 and -3 receptors are candidates for a role in the opiate withdrawal response in guinea-pigs.
Topics: Animals; Cerebral Ventricles; Guinea Pigs; Injections, Intraventricular; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Substance Withdrawal Syndrome | 1993 |
Substance P-evoked circular muscle contractions have a close connection with serotonergic neurons in guinea-pig ileum.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Serotonin; Substance P; Tropisetron | 1993 |
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin | 1993 |
Spinal effects of selective NK-1 and NK-2 receptor antagonists on bladder motility in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Afferent Pathways; Animals; Capsaicin; Indoles; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Spinal Cord; Substance P; Urinary Bladder; Urination | 1993 |
The effects of NK-1 and NK-2 receptor antagonists on the capsaicin evoked synaptic response in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biphenyl Compounds; Capsaicin; In Vitro Techniques; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P; Synapses | 1993 |
Interactions between excitatory amino acids and tachykinins and long-term changes of synaptic responses in the rat spinal dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; In Vitro Techniques; N-Methylaspartate; Neurokinin A; Neurons; Rats; Spinal Cord; Substance P; Synapses; Tetrodotoxin | 1993 |
Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesis.
Topics: Animals; Benzamides; Biphenyl Compounds; Models, Neurological; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bradykinin; Dose-Response Relationship, Drug; Evans Blue; Guinea Pigs; Histamine; Leukotriene D4; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Platelet Activating Factor; Receptors, Neurokinin-1; Skin; Substance P; Ureter | 1993 |
Investigations of the expression and post-translational processing of the preprotachykinin-I (PPT-I) gene by rat pancreatic, insulin-producing tumor cell-lines.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Gene Expression; Insulin; Insulinoma; Neurokinin A; Pancreatic Neoplasms; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoassay; Rats; Substance P; Tachykinins; Tumor Cells, Cultured | 1993 |
Potentiating effect of peptidase inhibitors on a C fiber-evoked response in the isolated spinal cord preparation of the neonatal rat.
Topics: Animals; Animals, Newborn; Captopril; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guanidines; Hydroxamic Acids; In Vitro Techniques; Kinetics; Leucine; Nerve Fibers; Neurokinin A; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Substance P; Tetrodotoxin; Thiorphan | 1993 |
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs.
Topics: Animals; Benzamides; Bronchial Spasm; Bronchoconstriction; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 1993 |
Tachykinin-mediated respiratory effects in conscious guinea pigs: modulation by NK1 and NK2 receptor antagonists.
Topics: Aerosols; Animals; Biphenyl Compounds; Capsaicin; Cell Membrane; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Receptors, Neurokinin-2; Respiration; Substance P; Tachykinins | 1993 |
Intranigral injection of selective neurokinin-1 and neurokinin-3 but not neurokinin-2 receptor agonists biphasically modulate striatal dopamine metabolism but not striatal preprotachykinin-A mRNA in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Female; Gene Expression Regulation; Injections; Neurokinin A; Neurokinin B; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; RNA, Messenger; Substance P; Substantia Nigra; Tachykinins | 1993 |
Primary structures and effects on gastrointestinal motility of tachykinins from the rainbow trout.
Topics: Amino Acid Sequence; Animals; Gastrointestinal Motility; Intestines; Molecular Sequence Data; Neurokinin A; Neuropeptides; Oncorhynchus mykiss; Peptide Fragments; Radioimmunoassay; Substance P; Tachykinins; Tissue Extracts | 1993 |
Effects of FK224, a novel cyclopeptide NK1 and NK2 antagonist, and CP-96,345, a nonpeptide NK1 antagonist, on development and maintenance of thermal hyperesthesia evoked by carrageenan injection in the rat paw.
Topics: Animals; Biphenyl Compounds; Carrageenan; Extremities; Hot Temperature; Hyperesthesia; Male; Neurokinin A; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Substance P | 1993 |
Identification of both NK1 and NK2 receptors in guinea-pig airways.
Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea | 1993 |
Substance P and neurokinin A induced desensitization to cardiovascular and behavioral effects: evidence for the involvement of different tachykinin receptors.
Topics: Animals; Behavior, Animal; Brain; Cardiovascular System; Drug Tolerance; Injections, Intraventricular; Male; Neurokinin A; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P | 1993 |
Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally.
Topics: Adolescent; Calcitonin Gene-Related Peptide; Female; Humans; Male; Migraine Disorders; Neurokinin A; Neuropeptides; Substance P | 1995 |
A silver-impregnation and immunocytochemical study of innervation of the distal sesamoid bone and its suspensory ligaments in the horse.
Topics: Animals; Calcitonin Gene-Related Peptide; Female; Horses; Immunohistochemistry; Ligaments, Articular; Male; Nerve Fibers; Neurokinin A; Sesamoid Bones; Silver Staining; Substance P | 1994 |
Neuropeptide modulation of chemically induced skin irritation.
Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission | 1995 |
Demonstration of a 'septide-sensitive' inflammatory response in rat skin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Dermatitis, Contact; Dose-Response Relationship, Drug; Edema; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Role of nitric oxide in tachykinin-induced increase in potential difference of rabbit tracheal mucosa.
Topics: Amiloride; Animals; Arginine; Electrophysiology; Epithelium; Histocytochemistry; Male; Membrane Potentials; Mucous Membrane; NADPH Dehydrogenase; Neurokinin A; Neurokinin B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rabbits; Substance P; Tachykinins; Trachea | 1995 |
Tachykinins activate nonselective cation currents in canine colonic myocytes.
Topics: Acetylcholine; Animals; Calcium Channels; Cations; Colon; Dogs; Electric Conductivity; Female; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Patch-Clamp Techniques; Substance P | 1995 |
Neurochemical markers of human fungiform papillae and taste buds.
Topics: Antibodies; Biomarkers; Calcitonin Gene-Related Peptide; Fluorescent Antibody Technique, Indirect; Galanin; Glutamic Acid; Humans; Nerve Tissue Proteins; Neurokinin A; Neuropeptide Y; S100 Proteins; Substance P; Taste Buds; Thiolester Hydrolases; Ubiquitin Thiolesterase; Vasoactive Intestinal Peptide | 1995 |
Comparative behavioural profile of centrally administered tachykinin NK1, NK2 and NK3 receptor agonists in the guinea-pig.
Topics: Animals; Behavior, Animal; Guinea Pigs; Injections, Intraventricular; Male; Motor Activity; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzamides; Dipeptides; Ethanol; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ion Channels; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Plant Extracts; Plants, Medicinal; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Antitussive and antibronchoconstriction actions of fenspiride in guinea-pigs.
Topics: Acetates; Acetic Acid; Aerosols; Airway Resistance; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin A; Spiro Compounds; Substance P | 1995 |
Further evidence that tachykinin-induced contraction of human isolated bronchus is mediated only by NK2-receptors.
Topics: Aged; Bronchi; Carbachol; Female; Glycopeptides; Humans; Male; Middle Aged; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Protease Inhibitors; Receptors, Neurokinin-2; Substance P; Tachykinins | 1995 |
In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
Topics: Amino Acid Sequence; Animals; Asthma; Bronchoconstriction; Capillary Permeability; Guinea Pigs; Humans; Inositol Phosphates; Male; Methacholine Chloride; Mice; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Rats; Receptors, Neurokinin-2; Respiration; Species Specificity; Substance P | 1996 |
Haemodynamic and immunohistochemical studies of rat incisor pulp after denervation and subsequent re-innervation.
Topics: Adrenergic alpha-Antagonists; Animals; Calcitonin Gene-Related Peptide; Denervation; Dental Pulp; Electric Stimulation; Hemodynamics; Immunohistochemistry; Incisor; Male; Mandibular Nerve; Nerve Fibers; Nerve Regeneration; Neurokinin A; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Serotonin; Substance P; Sympathetic Nervous System; Trigeminal Nerve; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilation | 1995 |
Role of nitric oxide in the actions of substance P and other mediators of inflammation in rat skin microvasculature.
Topics: Adenosine Triphosphate; Animals; Arginine; Capillary Permeability; Female; Inflammation Mediators; Male; Neurokinin A; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Serotonin; Skin; Substance P; Vasodilation | 1995 |
The design of dipeptide helical mimetics: the synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes.
Topics: Amino Acid Sequence; Animals; Biological Assay; Crystallography, X-Ray; Dipeptides; Humans; Indans; Models, Molecular; Molecular Mimicry; Molecular Sequence Data; Molecular Structure; Neurokinin A; Neurokinin B; Protein Conformation; Receptors, Tachykinin; Structure-Activity Relationship; Substance P | 1996 |
The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity.
Topics: Amino Acid Sequence; Binding, Competitive; Humans; Ligands; Membrane Proteins; Molecular Sequence Data; Neurokinin A; Neurokinin B; Phosphatidylinositols; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Structure-Activity Relationship; Substance P; Tachykinins | 1996 |
Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma.
Topics: Amino Acid Sequence; Benzamides; Biphenyl Compounds; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Chemokine CCL4; Connective Tissue; Depression, Chemical; Erythroid Precursor Cells; Hematopoietic Stem Cells; Humans; Macrophage Inflammatory Proteins; Molecular Sequence Data; Monokines; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transforming Growth Factor beta | 1996 |
Recognition of neurokinin 1 receptor (NK1-R): an antibody to a peptide sequence from the third extracellular region binds to brain NK1-R.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Affinity; Astrocytoma; Base Sequence; Binding Sites, Antibody; Binding, Competitive; Blotting, Western; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Protein Structure, Tertiary; Rabbits; Rats; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Tumor Cells, Cultured | 1996 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageenan; Hyperalgesia; Iontophoresis; Kaolin; Knee Joint; Male; Neurokinin A; Nociceptors; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Spinal Cord; Substance P | 1996 |
Effects of repeated sensory stimulation (electro-acupuncture) and physical exercise (running) on open-field behaviour and concentrations of neuropeptides in the hippocampus in WKY and SHR rats.
Topics: Animals; Depression; Electric Stimulation; Electroacupuncture; Exploratory Behavior; Galanin; Hippocampus; Hypertension; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Physical Exertion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Substance P; Vasoactive Intestinal Peptide | 1996 |
[Effects of substance P and neurokinin A on pulmonary circulation in the isolated perfused guinea pig lung].
Topics: Animals; Blood Pressure; Guinea Pigs; In Vitro Techniques; Lung; Neurokinin A; Pulmonary Circulation; Substance P; Vasoconstriction | 1996 |
Sensory neuropeptides are not directly involved in bronchial hyperresponsiveness induced by interleukin-8 in guinea-pigs in vivo.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dipeptides; Guinea Pigs; Histamine; Indoles; Interleukin-8; Male; Neurokinin A; Peptides, Cyclic; Substance P | 1996 |
Immunohistochemical, electrophysiological, and electron microscopical study of rat fungiform taste buds after regeneration of chorda tympani through the non-gustatory lingual nerve.
Topics: Animals; Calcitonin Gene-Related Peptide; Chorda Tympani Nerve; Electrophysiology; Immunohistochemistry; Lingual Nerve; Male; Microscopy, Electron; Nerve Regeneration; Neurokinin A; Phosphopyruvate Hydratase; Rats; Substance P; Taste Buds | 1996 |
Augmentation of neurally evoked cholinergic bronchoconstrictor responses by prejunctional NK2 receptors in the guinea-pig.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Medulla Oblongata; Methacholine Chloride; Muscle, Smooth; Neurokinin A; Neurokinin B; Piperidines; Substance P | 1996 |
In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.
Topics: Adrenergic Agents; Animals; Colon; Dose-Response Relationship, Drug; Guanethidine; Hexamethonium; Male; Muscle Contraction; Neurokinin A; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Tachykinins stimulate nitric oxide generation by canine cultured tracheal epithelium.
Topics: Animals; Arginine; Cells, Cultured; Dogs; Epithelium; Glycopeptides; Neurokinin A; Neurokinin B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Penicillamine; Receptors, Neurokinin-2; S-Nitroso-N-Acetylpenicillamine; Substance P; Trachea | 1995 |
Substance P enhances electrical field stimulation-induced mast cell degranulation in rat trachea.
Topics: Animals; Biphenyl Compounds; Capsaicin; Cell Degranulation; Chymotrypsin; Dose-Response Relationship, Drug; Electric Stimulation; Indomethacin; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Substance P; Trachea | 1996 |
Effects of substance P and selected other neuropeptides on the synthesis of interleukin-1 beta and interleukin-6 in human monocytes: a re-examination.
Topics: alpha-Endorphin; beta-Endorphin; Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Interleukin-1; Interleukin-6; Monocytes; Neurokinin A; Neuropeptides; Precipitin Tests; RNA, Messenger; Sincalide; Substance P; Vasoactive Intestinal Peptide | 1996 |
Two different approaches for developing immunometric assays of haptens.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Epitopes; Haptens; Immunoassay; Immunosorbent Techniques; Molecular Sequence Data; Neurokinin A; Peptides; Rats; Sensitivity and Specificity; Substance P | 1996 |
Temperature and agonist dependency of tachykinin NK1 receptor antagonist potencies in rat isolated superior cervical ganglion.
Topics: Animals; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, Neurokinin-1; Substance P; Superior Cervical Ganglion; Temperature; Tetrodotoxin | 1995 |
Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin1 (NK1) receptor antagonist CP-99,994.
Topics: Animals; Antiemetics; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Morphine; Neurokinin A; Nicotine; Piperidines; Receptors, Neurokinin-1; Shrews; Stereoisomerism; Substance P; Vomiting | 1995 |
Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Injections, Intravenous; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Substance P | 1996 |
Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages.
Topics: Animals; Bordetella pertussis; Cytochrome c Group; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Immunization; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Ovalbumin; Peptide Fragments; Protein Kinase C; Receptors, Tachykinin; Staurosporine; Substance P; Superoxides; Tachykinins; Tetradecanoylphorbol Acetate | 1996 |
Substance P and calcitonin gene-related peptide in the chicken skin: distribution and cardiovascular effects.
Topics: Acetylcholine; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Chickens; Dose-Response Relationship, Drug; Female; Heart Rate; Immunohistochemistry; Infusions, Intra-Arterial; Injections, Intravenous; Laser-Doppler Flowmetry; Male; Neurokinin A; Regional Blood Flow; Skin; Substance P; Vasodilation | 1996 |
Vasoconstrictive effects of native tachykinins in the rainbow trout, Oncorhynchus mykiss.
Topics: Amino Acid Sequence; Animals; Cardiovascular Physiological Phenomena; Cardiovascular System; Mammals; Molecular Sequence Data; Neurokinin A; Oncorhynchus mykiss; Perfusion; Species Specificity; Substance P; Tachykinins; Vasoconstriction; Vasoconstrictor Agents | 1996 |
Neurokinin subtype receptors mediating substance P contraction in immature rabbit airways.
Topics: Animals; Atropine; Bronchi; Glycopeptides; Isometric Contraction; Muscle, Smooth; Neostigmine; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1996 |
Effects of tachykinins on identified dorsal vagal neurons: an electrophysiological study in vitro.
Topics: Action Potentials; Animals; Brain Stem; Electrophysiology; Female; Histocytochemistry; In Vitro Techniques; Lysine; Male; Microelectrodes; Motor Neurons; Neurokinin A; Neurokinin B; Neurons; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Tachykinins; Vagus Nerve | 1996 |
SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.
Topics: Animals; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Repeated allergen exposure enhances excitatory nonadrenergic noncholinergic nerve-mediated bronchoconstriction in sensitized guinea-pigs.
Topics: Allergens; Animals; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Electric Stimulation; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Ovalbumin; Substance P | 1996 |
Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
Topics: Animals; Capillary Permeability; Edema; Glycopeptides; Male; Mice; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Substance P | 1996 |
A model for experimental induction of acute temporomandibular joint inflammation in rats: effects of substance P(SP) on neuropeptide-like immunoreactivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Disease Models, Animal; Inflammation; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders | 1996 |
Effects of extended sidestream smoke exposure on components of the C-fiber axon reflex.
Topics: Air Pollution, Indoor; Airway Resistance; Analysis of Variance; Animals; Bronchi; Guinea Pigs; Immunoenzyme Techniques; Immunohistochemistry; In Vitro Techniques; Injections, Intra-Arterial; Lung; Male; Nerve Fibers; Neurokinin A; Pulmonary Artery; Radioligand Assay; Substance P; Tobacco Smoke Pollution | 1996 |
Use of NK1 receptor antagonists in the exploration of physiological functions of substance P and neurokinin A.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Physalaemin; Rats; Substance P; Synaptic Transmission | 1995 |
Characterization of substance P release from the intermediate area of rat thoracic spinal cord.
Topics: 5,7-Dihydroxytryptamine; Animals; Autonomic Fibers, Preganglionic; Male; Nerve Endings; Neurokinin A; Neurotoxins; Potassium; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Spinal Cord; Substance P; Thorax; Thyrotropin-Releasing Hormone | 1996 |
Hybrid peptides having mixed substance P (NK1), neurokinin A (NK2) and bradykinin (BK2) antagonist properties.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Molecular Structure; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pulmonary Artery; Rabbits; Receptor, Bradykinin B2; Receptors, Neurokinin-2; Structure-Activity Relationship; Substance P | 1996 |
Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat.
Topics: Animals; Benzamides; Blood Pressure; Guinea Pigs; Hypotension; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Substance P and neurokinin A variations throughout the rat estrous cycle; comparison with ovariectomized and male rats: I. Plasma, hypothalamus, anterior and posterior pituitary.
Topics: Animals; Estradiol; Estrus; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Male; Neurokinin A; Ovariectomy; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Wistar; Substance P; Testosterone | 1996 |
Substance P and neurokinin A variations throughout the rat estrous cycle; comparison with ovariectomized and male rats: II. Trigeminal nucleus and cervical spinal cord.
Topics: Animals; Estrus; Female; Male; Neurokinin A; Ovariectomy; Radioimmunoassay; Rats; Rats, Wistar; Spinal Cord; Substance P; Trigeminal Nuclei | 1996 |
In vivo exposure to nitrogen dioxide (NO2) induces a decrease in calcitonin gene-related peptide (CGRP) and tachykinin immunoreactivity in guinea-pig peripheral airways.
Topics: Administration, Inhalation; Air Pollutants; Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Environmental Exposure; Guinea Pigs; Immunoenzyme Techniques; Irritants; Lung; Male; Nerve Fibers; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Neurons, Afferent; Nitrogen Dioxide; Oxidants, Photochemical; Substance P; Tachykinins; Thiolester Hydrolases; Ubiquitin Thiolesterase | 1996 |
Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Neurokinin A; Neurokinin B; Nitric Oxide; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea | 1996 |
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Postural Balance; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1996 |
Autoradiographic localization of tachykinin NK2 and NK1 receptors in the guinea-pig lung, using selective radioligands.
Topics: Animals; Autoradiography; Guinea Pigs; Lung; Muscle, Smooth; Neurokinin A; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 1996 |
Neurokinin A and senktide attenuate scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Amnesia; Animals; Male; Maze Learning; Mice; Neurokinin A; Peptide Fragments; Psychomotor Performance; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Scopolamine; Substance P | 1996 |
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P | 1996 |
Role of substance P and neurokinin A in toluene diisocyanate-induced increased airway responsiveness in rabbits.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Animals; Bronchi; Bronchoconstriction; Capsaicin; Disease Models, Animal; Lung Diseases; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Occupational Diseases; Rabbits; Receptors, Neurokinin-2; Substance P; Toluene 2,4-Diisocyanate; Trachea | 1996 |
Is the pretreatment effect of low dose Freund's adjuvant on adjuvant arthritis due to an activation of the nervous system?
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Freund's Adjuvant; Immunization; Male; Neurokinin A; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Substance P; Synovial Fluid | 1996 |
Tachykinin activation of human alveolar macrophages in tobacco smoke and sarcoidosis: a phenotypical and functional study.
Topics: Adult; Bronchoalveolar Lavage Fluid; Female; Humans; Immunophenotyping; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; Neurokinin A; Peptide Fragments; Peptidyl-Dipeptidase A; Receptors, Neurokinin-2; Respiratory Burst; Sarcoidosis, Pulmonary; Smoking; Substance P; Superoxides; Tachykinins | 1996 |
Effect of a new dual neurokinin antagonist on airway smooth muscle in situ.
Topics: Animals; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea | 1995 |
The cellular localization of the neuropeptides substance P, neurokinin A, calcitonin gene-related peptide and neuropeptide Y in guinea-pig vestibular sensory organs: a high-resolution confocal microscopy study.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Guinea Pigs; Immunohistochemistry; Microscopy, Confocal; Neurokinin A; Neuropeptide Y; Neuropeptides; Radioimmunoassay; Sensory Receptor Cells; Subcellular Fractions; Substance P; Vestibule, Labyrinth | 1996 |
Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation.
Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Female; Gene Expression Regulation; Guinea Pigs; Immunohistochemistry; In Situ Hybridization; Inflammation; Microscopy, Electron, Scanning; Neurokinin A; Neurons, Afferent; Nodose Ganglion; Ovalbumin; Radioimmunoassay; Respiratory Hypersensitivity; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Tachykinins; Vaccination | 1996 |
Isotonic smooth muscle response in human bronchi exposed in vitro to nitrogen dioxide.
Topics: Acetylcholine; Bronchi; Epithelium; Female; Humans; In Vitro Techniques; Isotonic Contraction; Male; Middle Aged; Muscle, Smooth; Neurokinin A; Nitrogen Dioxide; Oxidants, Photochemical; Substance P | 1996 |
Detection of naturally expressed receptors for gastrin-releasing peptide and tachykinins using cyanine 3-labelled neuropeptides.
Topics: 3T3 Cells; Animals; Carbocyanines; Endocytosis; Fluorescent Dyes; Mice; Microscopy, Confocal; Neurokinin A; Neurons; Neuropeptides; Rats; Receptors, Bombesin; Receptors, Tachykinin; Substance P | 1996 |
Substance P and neurokinin A metabolism by cultured human skeletal muscle myocytes and fibroblasts.
Topics: Adult; Blood Flow Velocity; Cells, Cultured; Dipeptidyl Peptidase 4; Fibroblasts; Humans; Muscle, Skeletal; Neprilysin; Neurokinin A; Substance P; Vascular Resistance | 1996 |
Tachykinin inhibition of acid-induced gastric hyperaemia in the rat.
Topics: Animals; Arginine Vasopressin; Female; Gastric Mucosa; Hemodynamics; Hydrochloric Acid; Hyperemia; Neurokinin A; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Regional Blood Flow; Stomach; Substance P; Tachykinins | 1996 |
Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; COS Cells; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Substance P | 1996 |
Microtopography of the autonomic nerves in the rat knee: a fluorescence microscopic study.
Topics: Animals; Arthritis, Experimental; Autonomic Pathways; Bone and Bones; Calcitonin Gene-Related Peptide; Immunohistochemistry; Knee Joint; Ligaments; Microscopy, Confocal; Microscopy, Fluorescence; Neurokinin A; Rats; Rats, Wistar; Substance P; Synovial Membrane; Tendons | 1997 |
Effect of celiac ganglionectomy on tachykinin innervation, receptor distribution and intestinal responses in the rat.
Topics: Animals; Ganglia, Sympathetic; Ganglionectomy; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins | 1996 |
A model for the study of experimentally induced temporomandibular arthritis in rats: the effect of human recombinant interleukin-1 alpha on neuropeptide-like immunoreactivity.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Humans; Interleukin-1; Male; Neuroimmunomodulation; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substance P; Synovial Fluid; Temporomandibular Joint; Temporomandibular Joint Disorders | 1996 |
Neuropeptides in the arthritic TMJ and symptoms and signs from the stomatognathic system with special consideration to rheumatoid arthritis.
Topics: Adult; Arthritis; Arthritis, Rheumatoid; Calcitonin Gene-Related Peptide; Female; Humans; Inflammation Mediators; Male; Middle Aged; Neuroimmunomodulation; Neurokinin A; Neuropeptide Y; Neuropeptides; Pain; Pain Measurement; Range of Motion, Articular; Statistics, Nonparametric; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 1995 |
Effects of adjuvant on neuropeptide-like immunoreactivity in experimentally induced temporomandibular arthritis in rats.
Topics: Animals; Arthritis, Experimental; Bacterial Proteins; Calcitonin Gene-Related Peptide; Immunohistochemistry; Male; Mycobacterium; Neuroimmunomodulation; Neurokinin A; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Substance P; Synovial Fluid; Temporomandibular Joint Disorders | 1996 |
Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Neurokinin A; Peptides, Cyclic; Propranolol; Substance P | 1996 |
Neurokinin A in rat renal afferent neurons and in nerve fibres within smooth muscle and epithelium of rat and guinea-pig renal pelvis.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Epithelium; Female; Ganglia, Spinal; Guinea Pigs; Immunohistochemistry; Kidney; Kidney Pelvis; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neurons, Afferent; Rats; Rats, Wistar; Species Specificity; Substance P; Ureter | 1997 |
Transglutaminase-synthesized spermine derivative of substance P recognizes rat portal vein neurokinin-3 receptors.
Topics: Androstanes; Animals; Benzimidazoles; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Physalaemin; Piperidines; Portal Vein; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Thiorphan; Transglutaminases; Vasoconstriction | 1997 |
Topical substance P and corneal epithelial wound closure in the rabbit.
Topics: Administration, Topical; Animals; Cornea; Corneal Injuries; Epithelium; Male; Neurokinin A; Ophthalmic Solutions; Piperidines; Rabbits; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Wound Healing | 1997 |
Immunocytochemical characterization of malignant schwannoma-derived cells in culture.
Topics: Calcitonin Gene-Related Peptide; Cell Communication; Cell Nucleus; Cell Survival; Collagen; Cytoplasm; Fibroblasts; Fibronectins; Fluorescent Antibody Technique, Direct; Humans; Immunohistochemistry; Laminin; Mast Cells; Neurilemmoma; Neurofilament Proteins; Neurokinin A; Phosphopyruvate Hydratase; S100 Proteins; Schwann Cells; Skin; Somatostatin; Substance P; Tumor Cells, Cultured; Vasoactive Intestinal Peptide; Vimentin | 1997 |
Neurokinin induced inositol phosphate production in guinea pig bladder.
Topics: Adenylyl Cyclases; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Inositol Phosphates; Male; Neurokinin A; Neurokinin B; Substance P; Urinary Bladder | 1997 |
Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Neurokinin A; Neurons, Afferent; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tetrodotoxin; Turtles | 1997 |
Sodium metabisulfite and citric acid induce bronchoconstriction via a sulfite-sensitive pathway in the isolated guinea pig lung.
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Animals; Autacoids; Bradykinin; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Calcitonin Gene-Related Peptide; Citric Acid; Guinea Pigs; Histamine; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Lung Compliance; Male; Neurokinin A; Neurons, Afferent; Serotonin; Substance P; Sulfites | 1997 |
Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1996 |
Morphologic maturation of tachykinin peptide-expressing cells in the postnatal rabbit retina.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies, Monoclonal; Immunohistochemistry; Neurokinin A; Neurokinin B; Rabbits; Retina; Retinal Ganglion Cells; Substance P; Tachykinins | 1997 |
An immunohistochemical screening of neurochemical markers in fungiform papillae and taste buds of the anterior rat tongue.
Topics: Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Dopamine beta-Hydroxylase; Fluorescent Antibody Technique, Indirect; Galanin; Gastrins; Glutamic Acid; Nerve Fibers; Nerve Tissue Proteins; Neurokinin A; Neuropeptide Y; Neuropeptides; Peptide PHI; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; S100 Proteins; Substance P; Taste Buds; Thiolester Hydrolases; Tongue; Ubiquitin Thiolesterase; Vasoactive Intestinal Peptide | 1997 |
Renal effects of intracerebroventricularly injected tachykinins in the conscious saline-loaded rat: receptor characterization.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Diuresis; Injections, Intraventricular; Kidney; Male; Natriuresis; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Vasopressins | 1997 |
Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins.
Topics: Animals; Capsaicin; Carbachol; Epithelium; Female; Growth Inhibitors; Guinea Pigs; Humans; Immunohistochemistry; In Vitro Techniques; Interleukin-6; Isoproterenol; Leukemia Inhibitory Factor; Lymphokines; Muscle Contraction; Neurokinin A; Substance P; Trachea | 1997 |
Use of antagonists to define tachykininergic control of intestinal motility in pigs.
Topics: Animals; Atropine; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Hexamethonium; Ileum; In Vitro Techniques; Neurokinin A; Perfusion; Phentolamine; Substance P; Swine; Tachykinins | 1997 |
Pre- and postjunctional inhibitory effects of fenspiride on guinea-pig bronchi.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Bronchodilator Agents; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Nerve Fibers; Neurokinin A; Neuropeptides; Peptide Fragments; Propranolol; Spiro Compounds; Substance P | 1997 |
Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.
Topics: Adenocarcinoma; Animals; Biocompatible Materials; Calcitonin Gene-Related Peptide; Cell Division; Cell Movement; Colforsin; Collagen; Colonic Neoplasms; Dideoxyadenosine; Dose-Response Relationship, Drug; Drug Combinations; Enkephalins; Laminin; Leucine; Mice; Neoplasm Invasiveness; Neurokinin A; Neuropeptide Y; Neuropeptides; Proteoglycans; Somatostatin; Substance P; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1997 |
An experimental study of the neurogenic and the immunological contribution to "tennis elbow" in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Injections, Intra-Arterial; Interleukin-1; Male; Neurokinin A; Neuropeptide Y; Neuropeptides; Perfusion; Rats; Rats, Sprague-Dawley; Substance P; Tennis Elbow | 1997 |
Effect of octreotide, a somatostatin analogue, on release of inflammatory mediators from isolated guinea pig bladder.
Topics: Animals; Bradykinin; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Inflammation Mediators; Leukotrienes; Neurokinin A; Octreotide; Prostaglandins; Substance P; Urinary Bladder | 1997 |
Possible different mechanism between amyloid-beta (25-35)-and substance P-induced chemotaxis of murine microglia.
Topics: Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Microglia; Neurofibrillary Tangles; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Substance P | 1997 |
Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.
Topics: Anesthetics; Animals; Benzamides; Blood Pressure; Calcitonin Gene-Related Peptide; Dura Mater; Indoles; Isoindoles; Male; Microscopy, Video; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Vasodilator Agents | 1997 |
Co-release of substance P and neurokinin A from the Atlantic cod stomach.
Topics: Animals; Electric Stimulation; Fishes; Gastric Mucosa; Gastrointestinal Motility; In Vitro Techniques; Injections, Intra-Arterial; Neurokinin A; Perfusion; Stomach; Substance P | 1997 |
CGRP potentiates excitatory transmission to the circular muscle of guinea-pig colon.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Colon; Electric Stimulation; Guanethidine; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurotransmitter Agents; Receptors, Cholinergic; Substance P; Synaptic Transmission; Tachykinins | 1997 |
PAMP is a novel inhibitor of the tachykinin release in the airway of guinea pigs.
Topics: Adrenomedullin; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Capsaicin; Guinea Pigs; Isoproterenol; Male; Neurokinin A; Peptide Fragments; Peptides; Proteins; Substance P | 1997 |
The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.
Topics: Animals; Behavior, Animal; Capillary Permeability; Gerbillinae; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Male; Morpholines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Plethysmography, Whole Body; Radioligand Assay; Receptors, Neurokinin-2; Respiratory Mechanics; Substance P; Tachykinins | 1997 |
Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction.
Topics: Acetylcholine; Adult; Aged; Bronchi; Capsaicin; Glycopeptides; Histamine; Humans; In Vitro Techniques; Leukotriene D4; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Protease Inhibitors; Receptors, Tachykinin; Substance P; Tachykinins | 1997 |
Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder.
Topics: Analgesics; Animals; Benzamides; Binding Sites; Inositol Phosphates; Male; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins; Tritium; Type C Phospholipases; Urinary Bladder | 1997 |
Effect of angiotensin II on a spinal nociceptive reflex in the rat: receptor and mechanism of action.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Imidazoles; Injections, Spinal; Losartan; Male; Naloxone; Neurokinin A; Neurokinin B; Nociceptors; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P; Tetrazoles | 1997 |
Distribution and colocalization of calcitonin gene-related peptide, tachykinins, and vasoactive intestinal peptide in normal and idiopathic unstable human urinary bladder.
Topics: Adult; Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Female; Humans; Immunoenzyme Techniques; Middle Aged; Neurokinin A; Neurons, Afferent; Substance P; Tachykinins; Urinary Bladder; Urination Disorders; Vasoactive Intestinal Peptide | 1997 |
Mechanisms of electrolyte transport across the endometrium. II. Regulation by GRP and substance P.
Topics: Amiloride; Animals; Biological Transport; Cell Membrane Permeability; Electrolytes; Female; Gastrin-Releasing Peptide; Gastrointestinal Hormones; Ionomycin; Kinetics; Membrane Potentials; Models, Biological; Mucous Membrane; Myometrium; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Potassium; Substance P; Swine; Thapsigargin | 1997 |
Indomethacin influences regulatory peptides and increases DNA synthesis in the gastrointestinal tract of the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Division; Colon; Digestive System; Dinoprostone; DNA; Gastric Mucosa; Gastrins; Glucagon; Indomethacin; Intestinal Mucosa; Intestine, Small; Neurokinin A; Neuropeptides; Neurotensin; Rats; Rats, Sprague-Dawley; Somatostatin; Stomach; Substance P | 1997 |
Neurokinin receptors (NK1, NK2) in the mouse: a pharmacological study.
Topics: Animals; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Substance P; Tachykinins; Urinary Bladder | 1997 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Tachykinin-induced contractions of the guinea pig ileum longitudinal smooth muscle: tonic and phasic muscular activities.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Substance P; Tachykinins | 1997 |
Kinin receptors in the diabetic mouse.
Topics: Acetylcholine; Animals; Bradykinin; Diabetes Mellitus, Experimental; Gastric Fundus; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Neurokinin A; Receptors, Tachykinin; Reference Values; Substance P | 1997 |
Goldfish gamma-preprotachykinin mRNA encodes the neuropeptides substance P, carassin, and neurokinin A.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; DNA, Complementary; Fishes; Goldfish; Male; Mammals; Molecular Sequence Data; Neurokinin A; Peptide Mapping; Polymerase Chain Reaction; Protein Precursors; Ranidae; RNA, Messenger; Sequence Alignment; Substance P; Tachykinins | 1997 |
Endotoxin actions on myoelectric activity, transit, and neuropeptides in the gut. Role of nitric oxide.
Topics: Animals; Calcitonin Gene-Related Peptide; Dexamethasone; Dose-Response Relationship, Drug; Escherichia coli; Gastrointestinal Transit; Intestine, Small; Lipopolysaccharides; Male; Myoelectric Complex, Migrating; Neurokinin A; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Substance P | 1997 |
Histamine release from human bronchoalveolar lavage mast cells by neurokinin A and bradykinin.
Topics: Bradykinin; Bronchoalveolar Lavage Fluid; Calcimycin; Female; Histamine Release; Humans; Ionophores; Male; Mast Cells; Middle Aged; Neurokinin A; p-Methoxy-N-methylphenethylamine; Substance P | 1997 |
Tachykinins influence interdigestive rhythm and contractile strength of human small intestine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Humans; Intestine, Small; Male; Manometry; Muscle Contraction; Muscle, Smooth; Myoelectric Complex, Migrating; Neurokinin A; Sodium Chloride; Substance P | 1997 |
Neurokinin A-LI release after antigen challenge in guinea-pig bronchial tubes: influence of histamine and bradykinin.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Bronchi; Capsaicin; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Ovalbumin; Pyrilamine; Substance P; Trachea | 1997 |
Potencies of agonists acting at tachykinin receptors in the oestrogen-primed rat uterus: effects of peptidase inhibitors.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estradiol; Female; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins; Uterine Contraction; Uterus | 1997 |
Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Male; N-Methylaspartate; Neurokinin A; Pain; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P; Sulfonamides | 1997 |
Gly166 in the NK1 receptor regulates tachykinin selectivity and receptor conformation.
Topics: Amino Acid Substitution; Animals; Binding Sites; CHO Cells; COS Cells; Cricetinae; Cysteine; Dithiothreitol; Ethylmaleimide; Glycine; Humans; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Neurokinin B; Protein Conformation; Rats; Receptors, Neurokinin-1; Receptors, Tachykinin; Recombinant Proteins; Substance P | 1997 |
Cellular pathways mediating tachykinin-evoked secretomotor responses in guinea pig ileum.
Topics: Animals; Capsaicin; Electric Stimulation; Evoked Potentials; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins | 1997 |
Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn.
Topics: Animals; Benzamides; Biphenyl Compounds; Cats; Iontophoresis; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Stereoisomerism; Substance P; Synapses | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Substance P and neurokinin A in gingival crevicular fluid in periodontal health and disease.
Topics: Adult; Alveolar Bone Loss; Female; Gingival Crevicular Fluid; Gingival Hemorrhage; Gingival Pocket; Gingivitis; Humans; Male; Neurokinin A; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Periodontium; Radioimmunoassay; Substance P | 1997 |
KF19514, a phosphodieterase 4 and 1 inhibitor, inhibits PAF-induced lung inflammatory responses by inhaled administration in guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Electric Stimulation; Eosinophils; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Naphthyridines; Neurokinin A; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Activating Factor; Pyrrolidinones; Respiratory Therapy; Rolipram; Substance P | 1997 |
Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro.
Topics: Animals; Bronchoconstriction; Capsaicin; In Vitro Techniques; Male; Mast Cells; Neurokinin A; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Serotonin; Substance P; Tachykinins; Trachea | 1997 |
Tachykinins (substance P, neurokinin A and neuropeptide gamma) and neurotensin from the intestine of the Burmese python, Python molurus.
Topics: Animals; Boidae; Chromatography, Gel; Chromatography, High Pressure Liquid; Evolution, Molecular; Intestines; Neurokinin A; Neuropeptides; Neurotensin; Peptide Fragments; Sequence Analysis; Sequence Homology, Amino Acid; Substance P; Tachykinins | 1997 |
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve | 1997 |
Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dipeptides; Fluorometry; Guinea Pigs; Indoles; Lanthanum; Myenteric Plexus; Neurokinin A; Nickel; Nifedipine; Peptide Fragments; Peptides, Cyclic; Receptors, Tachykinin; Substance P; Tachykinins; Virulence Factors, Bordetella | 1998 |
Response of isolated human neurogenic bladders to tachykinins.
Topics: Adolescent; Atropine; Child; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Meningomyelocele; Muscle Contraction; Neurokinin A; Neurokinin B; Sacrococcygeal Region; Substance P; Tachykinins; Urinary Bladder, Neurogenic | 1997 |
Sensory nerves in the interface membrane of aseptic loose hip prostheses.
Topics: Aged; Aged, 80 and over; Calcitonin Gene-Related Peptide; Female; Hip Prosthesis; Humans; Immunohistochemistry; Male; Membranes; Middle Aged; Nerve Fibers; Neurokinin A; Neuropeptides; Prosthesis Failure; Substance P | 1998 |
Projections and actions of tachykininergic, cholinergic, and serotonergic neurones in the intestine of the atlantic cod.
Topics: Animals; Antibodies; Carrier Proteins; Choline O-Acetyltransferase; Female; Fishes; Galanin; Immunohistochemistry; Intestines; Male; Membrane Transport Proteins; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Neurons; Nitric Oxide Synthase; Serotonin; Substance P; Tachykinins; Vasoactive Intestinal Peptide; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1998 |
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Topics: Acetic Acid; Alleles; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Formaldehyde; Ganglia, Spinal; Gene Deletion; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Neurons; Pain; Spinal Cord; Substance P | 1998 |
Mediation of irregular spiking activity by multiple neurokinin-receptors in the small intestine of the rat.
Topics: Animals; Electromyography; Electrophysiology; Gastrointestinal Motility; Intestine, Small; Male; Myoelectric Complex, Migrating; Neurokinin A; Neurokinin B; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 1998 |
Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition.
Topics: Animals; Baclofen; Bicuculline; Entorhinal Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Phosphinic Acids; Propanolamines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Receptors, GABA-B; Substance P; Synapses; Tachykinins | 1998 |
[Tachykinin receptor subtypes involved in endothelium-dependent and -independent responses in rabbit intrapulmonary arteries].
Topics: Animals; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Artery; Rabbits; Receptors, Tachykinin; Substance P | 1997 |
Cultured rat sensory neurones express functional tachykinin receptor subtypes 1, 2 and 3.
Topics: Analysis of Variance; Animals; Cells, Cultured; Ganglia, Spinal; Neurokinin A; Neurokinin B; Neurons, Afferent; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P | 1998 |
Nociceptive inhibition of migrating myoelectric complex by nitric oxide and monoaminergic pathways in the rat.
Topics: Animals; Biogenic Monoamines; Calcitonin Gene-Related Peptide; Electromyography; Injections, Intraperitoneal; Male; Myoelectric Complex, Migrating; Neurokinin A; Neuropeptide Y; Neuropeptides; Neurotensin; Nitric Oxide; Nociceptors; Rats; Rats, Sprague-Dawley; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1998 |
Substance P equals pain substance?
Topics: Analgesics; Animals; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Pain; Protein Precursors; Receptors, Neurokinin-1; Substance P; Tachykinins | 1998 |
Primary afferent tachykinins are required to experience moderate to intense pain.
Topics: Animals; Cloning, Molecular; Female; Gene Targeting; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neuritis; Neurokinin A; Nociceptors; Pain; Protein Precursors; Receptors, Neurokinin-1; Sensory Thresholds; Sequence Deletion; Stimulation, Chemical; Substance P; Tachykinins | 1998 |
Tachykinin NK2 receptors predominantly mediate tachykinin-induced contractions in ovine trachea.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Female; Muscle Contraction; Neprilysin; Neurokinin A; Receptors, Tachykinin; Sheep; Substance P; Tachykinins; Trachea | 1998 |
Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.
Topics: Animals; Calcium; Colon; Enteric Nervous System; Guinea Pigs; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Tachykinin; Substance P; Tachykinins | 1998 |
Membrane-induced secondary structures of neuropeptides: a comparison of the solution conformations adopted by agonists and antagonists of the mammalian tachykinin NK1 receptor.
Topics: Amino Acid Sequence; Membranes; Micelles; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neuropeptides; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Structure, Secondary; Receptors, Neurokinin-1; Sodium Dodecyl Sulfate; Solutions; Substance P | 1998 |
Neurogenic and non-neurogenic responses in the urinary bladder of hibernating hamster.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Cricetinae; Electric Stimulation; Hibernation; Male; Mesocricetus; Neurokinin A; Substance P; Synaptic Transmission; Urinary Bladder; Vasoactive Intestinal Peptide | 1998 |
Effects of endotracheal intubation on airway neuropeptide content, arterial oxygenation and lung volumes in anaesthetized rats.
Topics: Anesthesia, General; Animals; Arteries; Calcitonin Gene-Related Peptide; Capsaicin; Intubation, Intratracheal; Lung Volume Measurements; Neurokinin A; Neuropeptides; Oxygen; Pulmonary Gas Exchange; Rats; Rats, Sprague-Dawley; Respiratory System; Substance P; Vasoactive Intestinal Peptide | 1998 |
Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.
Topics: Animals; Antigens; Blood Proteins; Capsaicin; Dextrans; Dipeptides; Extravasation of Diagnostic and Therapeutic Materials; Fluorescein-5-isothiocyanate; Glycopeptides; Guinea Pigs; Indoles; Male; Nasal Mucosa; Neurokinin A; Neurokinin-1 Receptor Antagonists; Olfactory Receptor Neurons; Peptide Fragments; Peptides, Cyclic; Protease Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rhinitis; Substance P | 1997 |
Changes in tachykinin--ergic nerve terminal densities in rat nasal mucosa during hypersensitivity.
Topics: Animals; Female; Male; Nasal Mucosa; Nerve Endings; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Rhinitis, Allergic, Perennial; Substance P; Tachykinins; Toluene 2,4-Diisocyanate | 1997 |
Identification of bradykinin, substance P, and neurokinin A in human dental pulp.
Topics: Animals; Bradykinin; Cattle; Chromatography, High Pressure Liquid; Dental Pulp; Humans; Inflammation Mediators; Neurokinin A; Neurotransmitter Agents; Serum Albumin, Bovine; Substance P | 1997 |
Tachykinin receptors are present on human monocytes and play a role in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cell Separation; Female; Humans; Male; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Activation of non-adrenergic non-cholinergic inhibitory pathways by endogenous and exogenous tachykinins in the ferret lower oesophageal sphincter.
Topics: Animals; Capsaicin; Electric Stimulation; Esophagogastric Junction; Female; Ferrets; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetrodotoxin | 1998 |
Presence of NK1 receptors on a mucosal-like mast cell line, RBL-2H3 cells.
Topics: Animals; Binding, Competitive; Cells, Cultured; Mast Cells; Neurokinin A; Peptide Fragments; Polymerase Chain Reaction; Rats; Receptors, Neurokinin-1; Substance P | 1998 |
Increased concentrations of calcitonin gene-related peptide-like immunoreactivity in rat brain and peripheral tissue after ischaemia: correlation to flap survival.
Topics: Animals; Biopsy; Brain Chemistry; Calcitonin Gene-Related Peptide; Cerebral Cortex; Cross Reactions; Ischemia; Male; Neurokinin A; Neuropeptide Y; Rats; Rats, Inbred WKY; Substance P; Surgical Flaps; Sympathetic Nervous System | 1998 |
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve | 1998 |
[Immunohistochemical study on three peptidergic terminals in nasal mucosa in a rat AR model].
Topics: Animals; Female; Immunohistochemistry; Male; Nasal Mucosa; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Rhinitis, Allergic, Perennial; Substance P; Tachykinins; Toluene 2,4-Diisocyanate | 1996 |
An experimental model of tennis elbow in rats: a study of the contribution of the nervous system.
Topics: Animals; Calcitonin Gene-Related Peptide; Carrageenan; Disease Models, Animal; Freund's Adjuvant; Immunohistochemistry; Male; Nervous System; Neurokinin A; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Sympathetic Nervous System; Tennis Elbow | 1998 |
High affinity binding sites for [3H]substance P in urinary bladders of cats with interstitial cystitis.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Blood Vessels; Brain; Cats; Cystitis, Interstitial; Female; Iodine Radioisotopes; Male; Neurokinin A; Neurokinin B; Pain; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Substrate Specificity; Tritium; Up-Regulation; Urinary Bladder | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
Involvement of dopamine receptors in beneficial effects of tachykinins on scopolamine-induced impairment of alternation performance in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amnesia; Animals; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Male; Memory; Mice; Neurokinin A; Peptide Fragments; Phenethylamines; Receptors, Cholinergic; Receptors, Dopamine D1; Receptors, Dopamine D2; Scopolamine; Substance P; Sulpiride; Tachykinins | 1998 |
A method to measure dual NK1/NK2-antagonist activity in dogs.
Topics: Animals; Benzamides; Dogs; Male; Neurokinin A; Piperidines; Propofol; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory System; Substance P; Tachykinins | 1998 |
Tachykinins in the pineal gland: effect of castration and ganglionectomy.
Topics: Animals; Castration; Circadian Rhythm; Ganglionectomy; Immunohistochemistry; Male; Neurokinin A; Pineal Gland; Rats; Rats, Sprague-Dawley; Rats, Wistar; Substance P | 1998 |
Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Female; Humans; Male; Methacholine Chloride; Neurokinin A; Radioimmunoassay; Statistics, Nonparametric; Substance P | 1998 |
Histological and ultrastructural studies of the effects of tachykinins on protein secretion from the lingual epithelium and the lingual gland of the Tokyo daruma pond frog (Rana porosa porosa).
Topics: Animals; Cytoplasmic Granules; Eledoisin; Epithelial Cells; Female; Male; Mouth Mucosa; Mucus; Neurokinin A; Physalaemin; Ranidae; Saliva; Salivary Glands; Salivary Proteins and Peptides; Salivation; Substance P; Tachykinins; Tongue | 1998 |
Point mutation increases a form of the NK1 receptor with high affinity for neurokinin A and B and septide.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Neurokinin A; Neurokinin B; Peptide Fragments; Point Mutation; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1998 |
Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors.
Topics: Animals; Dogs; Heart; Myocardial Contraction; Neurokinin A; Neurons, Afferent; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1998 |
Tachykinins as enhancers of prostaglandin E2-induced intraocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Endophthalmitis; Eye; Eye Proteins; Hyperemia; Indomethacin; Injections; Iris; Male; Miosis; Neurokinin A; Rabbits; Substance P; Tachykinins; Vitreous Body | 1998 |
Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide.
Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Male; Muscle, Skeletal; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P | 1998 |
Signaling pathways via NK1 receptors and their desensitization in an AR42J cell line.
Topics: Animals; Calcium Signaling; Carcinoma, Acinar Cell; Cyclic AMP; Desensitization, Immunologic; Hydrolysis; Neurokinin A; Neurokinin B; Pancreatic Neoplasms; Phosphatidylinositols; Rats; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tumor Cells, Cultured | 1998 |
Tachykinins mediate changes in ion transport in porcine jejunum through release of prostaglandins and neurotransmitters.
Topics: Animals; Dinoprostone; Electrophysiology; Female; Ion Transport; Jejunum; Male; Neurokinin A; Neurotransmitter Agents; Piroxicam; Prostaglandins; Substance P; Swine; Tachykinins; Tetrodotoxin; Vasoactive Intestinal Peptide | 1998 |
Vascular protein leakage in the rat parotid gland elicited by reflex stimulation, parasympathetic nerve stimulation and administration of neuropeptides.
Topics: Animals; Blood Proteins; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Electric Stimulation; Evans Blue; Female; Food; Male; Neurokinin A; Neuropeptides; Parasympathetic Nervous System; Parotid Gland; Pilocarpine; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide | 1998 |
Ameliorative effects of tachykinins on scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Animals; Male; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Peptide Fragments; Psychomotor Performance; Scopolamine; Substance P; Tachykinins | 1998 |
Plasma substance-P and substance-K and gonadal steroids in relation to the gonadotropin surge in normal human reproductive cycles.
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Immunoenzyme Techniques; Luteinizing Hormone; Menstrual Cycle; Microspheres; Neurokinin A; Progesterone; Radioimmunoassay; Substance P | 1998 |
Antagonists of sensory neuropeptides inhibit the secondary phase of increased circulation following thermally induced inflammation.
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Extremities; Inflammation; Male; Microcirculation; Neurokinin A; Rats; Rats, Sprague-Dawley; Substance P | 1998 |
Ovarian steroid modulation of neurokinin contents in hypothalamus, pituitary, trigeminal nucleus, and cervical spinal cord of the ovariectomized female rat.
Topics: Animals; Central Nervous System; Estradiol; Female; Hypothalamus; Luteinizing Hormone; Neck; Neurokinin A; Osmolar Concentration; Ovariectomy; Pituitary Gland; Progesterone; Rats; Rats, Wistar; Spinal Cord; Substance P; Trigeminal Nuclei | 1998 |
Functional characterisation of tachykinin receptors mediating ion transport in porcine jejunum.
Topics: Animals; Binding, Competitive; Electric Stimulation; Evoked Potentials; Female; In Vitro Techniques; Indoles; Ion Transport; Isoindoles; Jejunum; Male; Membrane Potentials; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Swine | 1998 |
Peptidergic control of gastrointestinal blood flow in the estuarine crocodile, Crocodylus porosus.
Topics: Alligators and Crocodiles; Animals; Arteries; Calcitonin Gene-Related Peptide; Celiac Artery; Digestive System; Epinephrine; Galanin; Mesenteric Arteries; Neurokinin A; Neuropeptide Y; Neuropeptides; Regional Blood Flow; Somatostatin; Substance P; Vascular Resistance; Vasoactive Intestinal Peptide; Vasoconstrictor Agents | 1998 |
Characterization of responses to neurokinin A in the isolated perfused guinea pig heart.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Binding Sites; Cardiac Pacing, Artificial; Coronary Vessels; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Neurokinin A; Perfusion; Reserpine; Substance P; Theophylline | 1998 |
Effect of sensory neuropeptides on mucus secretion from cultured goblet cells.
Topics: Animals; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Exocytosis; Guinea Pigs; Male; Mucus; Neurokinin A; Neurokinin B; Substance P; Trachea | 1998 |
Intraduodenal neuropeptide levels, but not plasma levels, vary in a cyclic fashion with the migrating motor complex.
Topics: Adult; Chromatography, High Pressure Liquid; Duodenum; Fasting; Gastrointestinal Motility; Humans; Male; Motilin; Myoelectric Complex, Migrating; Neurokinin A; Neuropeptides; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1998 |
Subthreshold concentration of endothelin-1-enhanced, capsaicin-induced bronchoconstriction in anaesthetized guinea-pigs.
Topics: Aerosols; Airway Resistance; Anesthesia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Guinea Pigs; Male; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Substance P | 1998 |
Mechanism of tachykinin NK3 receptor-mediated colonic ion transport in the guinea pig.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Male; Neurokinin A; Neuropeptides; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins | 1998 |
Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors.
Topics: Cell Division; DNA, Neoplasm; Glioma; Humans; Interleukin-10; Interleukin-6; Neoplasm Proteins; Neurokinin A; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Substance P; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Rat gastrointestinal motor responses mediated via activation of neurokinin receptors.
Topics: Animals; Chromates; Chromium Radioisotopes; Gastric Emptying; Gastrointestinal Motility; Intubation, Gastrointestinal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sodium Compounds; Substance P | 1999 |
Alterations in neurokinin A-, substance P- and calcitonin gene-related peptide immunoreactivities in the caudal trigeminal nucleus of the rat following electrical stimulation of the trigeminal ganglion.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Female; Immunohistochemistry; Male; Neurokinin A; Nociceptors; Rats; Rats, Wistar; Substance P; Trigeminal Ganglion; Trigeminal Nuclei | 1999 |
Substance P and the neurokinins: novel peptide neurotransmitters in psychopharmacology.
Topics: Humans; Neurokinin A; Neurokinin B; Neurotransmitter Agents; Psychotropic Drugs; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Terminology as Topic | 1999 |
Defects of tyrosine289phenylalanine mutation on binding and functional properties of the human tachykinin NK2 receptor stably expressed in chinese hamster ovary cells.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanosine Triphosphate; Humans; Inositol 1,4,5-Trisphosphate; Neurokinin A; Phenoxybenzamine; Phenylalanine; Point Mutation; Receptors, Neurokinin-2; Signal Transduction; Substance P; Tachykinins; Transfection; Tyrosine | 1999 |
Characterization of [3H]substance P binding sites in human skin.
Topics: Aged; Binding, Competitive; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Neurokinin A; Neurokinin B; Peptide Fragments; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Skin; Substance P; Tritium | 1999 |
Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Gene Expression; Humans; Male; Middle Aged; Monocytes; Neurokinin A; Neurokinin B; Receptors, Tachykinin; RNA, Messenger; Substance P; Superoxides; Tumor Necrosis Factor-alpha | 1998 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Nociceptin receptor activation inhibits tachykinergic non adrenergic non cholinergic contraction of guinea pig isolated bronchus.
Topics: Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Nociceptin Receptor; Receptors, Opioid; Receptors, Tachykinin; Substance P | 1999 |
Identification in the NK1 tachykinin receptor of a domain involved in recognition of neurokinin A and septide but not of substance P.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Chlorocebus aethiops; COS Cells; DNA, Complementary; Humans; In Vitro Techniques; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Point Mutation; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Tachykinins | 1999 |
Expression of neurokinin-1 receptors on cultured dorsal root ganglion neurons from the adult rat.
Topics: Animals; Cells, Cultured; Ganglia, Spinal; Kinetics; Male; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 1999 |
Opioid activity of sendide, a tachykinin NK1 receptor antagonist.
Topics: Analgesics; Animals; Behavior, Animal; Bombesin; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Opioid; Substance P | 1999 |
Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Electric Stimulation; Female; Ganglia, Spinal; Ganglia, Sympathetic; Hair; Hindlimb; Nerve Fibers; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P; Vasodilation | 1999 |
The tachykinins neurokinin A and substance P, but not neurokinin B, stimulate contraction of isolated muscle cells from rat small intestine.
Topics: Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Intestine, Small; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Smooth; Neurokinin A; Neurokinin B; Rats; Substance P | 1999 |
Differential modulation of human immunoglobulin isotype production by the neuropeptides substance P, NKA and NKB.
Topics: B-Lymphocytes; Cells, Cultured; DNA Primers; Enzyme-Linked Immunosorbent Assay; Epitopes; Gene Expression; Humans; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Interleukin-5; Lymphocyte Activation; Mucous Membrane; Neuroimmunomodulation; Neurokinin A; Neurokinin B; Pokeweed Mitogens; Receptors, Neurokinin-1; RNA, Messenger; Sensitivity and Specificity; Substance P; T-Lymphocytes; Tachykinins; Transforming Growth Factor beta | 1999 |
Nanomolar concentrations of neuropeptides induce histamine release from peritoneal mast cells of a substrain of Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Histamine Release; Male; Mast Cells; Neurokinin A; Peritoneum; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Substance P; Tachykinins | 1999 |
Central tachykinin NK3 receptors in the inhibitory action on the rat colonic propulsion of a new tachykinin, PG-KII.
Topics: Animals; Colon; Gastrointestinal Transit; Injections, Intraventricular; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.
Topics: Aggression; Analgesics, Opioid; Animals; Antibodies, Blocking; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Nociceptin; Opioid Peptides; Piperidines; Receptors, Neurokinin-1; Receptors, Opioid; Spinal Cord; Substance P | 1999 |
Developmental changes of hypothalamic, pituitary and striatal tachykinins in response to testosterone: influence of prenatal melatonin.
Topics: Animals; Corpus Striatum; Female; Hypothalamus; Male; Melatonin; Neurokinin A; Pituitary Gland, Anterior; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Substance P; Tachykinins; Testosterone | 1999 |
Transgenic mice overexpressing the growth-hormone-releasing hormone gene have high concentrations of tachykinins in the anterior pituitary gland.
Topics: Animals; Female; Growth Hormone-Releasing Hormone; Hormone Antagonists; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Neurokinin A; Organ Size; Ovariectomy; Pituitary Gland, Anterior; Sex Characteristics; Somatostatin; Substance P; Tachykinins; Triiodothyronine | 1999 |
Tachykinins stimulate acid and pepsinogen secretion in the isolated porcine stomach.
Topics: Animals; Capsaicin; Electric Stimulation; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Neurokinin A; Pepsinogen A; Radioimmunoassay; Substance P; Swine; Tachykinins; Vagus Nerve | 1999 |
Tachykinins stimulate release of peptide hormones (glucagon-like peptide-1) and paracrine (somatostatin) and neurotransmitter (vasoactive intestinal polypeptide) from porcine ileum through NK-1 receptors.
Topics: Animals; Cholinergic Fibers; Glucagon; Glucagon-Like Peptide 1; Ileum; Neurokinin A; Neurons; Peptide Fragments; Protein Precursors; Receptors, Neurokinin-1; Sensory Receptor Cells; Somatostatin; Stimulation, Chemical; Substance P; Swine; Vasoactive Intestinal Peptide | 1999 |
Tachykinin receptors mediating contractions of oestrogen-primed rat uterus: classification using non-peptide antagonists.
Topics: Animals; Estradiol; Female; Neurokinin A; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Tachykinins; Uterine Contraction | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats.
Topics: Acetylcholine; Animals; Atropine; Colitis; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nicotinic Antagonists; Parasympatholytics; Potassium Chloride; Rats; Rats, Sprague-Dawley; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Vasodilator Agents | 1999 |
Tachykinins (substance P and neuropeptide gamma) from the brains of the pallid sturgeon, Scaphirhynchus albus and the paddlefish, Polyodon spathula (Acipenseriformes).
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Fishes; Humans; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Neurokinin A; Sequence Homology; Substance P; Trout | 1999 |
Decreased neuropeptide release may play a role in the pathogenesis of nasal polyps.
Topics: Adolescent; Adult; Calcitonin Gene-Related Peptide; Capsaicin; Female; Humans; Male; Middle Aged; Nasal Mucosa; Nasal Polyps; Neurokinin A; Neuropeptides; Nose Neoplasms; Prospective Studies; Reference Values; Respiratory Hypersensitivity; Substance P | 1999 |
Effects of nerve stimulation on spontaneously active preparations of the guinea pig ureter.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Electrophysiology; Guinea Pigs; Humans; In Vitro Techniques; Motor Activity; Nervous System Physiological Phenomena; Neurokinin A; Peptides, Cyclic; Substance P; Tachykinins; Thiorphan; Ureter; Urinary Tract Physiological Phenomena | 1999 |
The importance of C-terminal residues of vertebrate and invertebrate tachykinins for their contractile activities in gut tissues.
Topics: Amino Acid Substitution; Animals; Arginine; Cockroaches; Guinea Pigs; Helminth Proteins; Male; Methionine; Muscle Contraction; Neurokinin A; Neurokinin B; Neuropeptides; Species Specificity; Substance P | 1999 |
Modulation of sympathetic nerve activity by perivascular sensory nerves in the arterioles of the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Arterioles; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Membrane Potentials; Neurokinin A; Neurons, Afferent; Substance P; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction | 1999 |
Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Electric Stimulation; Ferrets; Histamine Antagonists; Male; Mucus; Neurokinin A; Parasympathetic Nervous System; Receptors, Neurokinin-1; Spiro Compounds; Substance P; Sulfates; Sulfur Radioisotopes; Trachea | 1999 |
A transient geniculo-extrastriate pathway in macaques? Implications for 'blindsight'.
Topics: Aging; Animals; Blindness; Calcitonin Gene-Related Peptide; Female; Geniculate Bodies; Macaca mulatta; Neurokinin A; Substance P; Visual Cortex; Visual Pathways | 1999 |
Nerve-mediated motility of ileal segments isolated from NK(1) receptor knockout mice.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Gastrointestinal Motility; Ileum; Male; Mice; Mice, Knockout; Neurokinin A; Neurons, Afferent; Nitric Oxide; Organ Culture Techniques; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-1; Substance P; Synaptic Transmission | 1999 |
Pharmacological examination of the neurokinin-1 receptor mediating relaxation of human intralobar pulmonary artery.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Epoprostenol; Female; Humans; In Vitro Techniques; Lung; Male; Middle Aged; Neurokinin A; Nitric Oxide; Peptide Fragments; Phenylephrine; Pulmonary Artery; Receptors, Neurokinin-1; Receptors, Tachykinin; Substance P; Vasoconstriction; Vasodilation | 2000 |
Reactivity of intrarenal arteries to vasoconstrictor and vasorelaxant polypeptides in adult stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Endothelin-1; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Neurokinin A; Neuropeptides; Peptide PHI; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Species Specificity; Substance P; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilation; Vasopressins | 1999 |
Distributions of VIP, substance P, neurokinin A and neurotensin in rat heart: an immunocytochemical study.
Topics: Animals; Autonomic Nervous System; Coronary Circulation; Heart; Heart Atria; Heart Ventricles; Immunohistochemistry; Muscle, Smooth, Vascular; Nerve Fibers; Neurokinin A; Neuropeptides; Neurotensin; Radioimmunoassay; Rats; Substance P; Vasoactive Intestinal Peptide; Vasoconstriction | 1999 |
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea | 1999 |
Tachykinin NK(3)receptor involvement in anxiety.
Topics: Animals; Anxiety; Cerebral Ventricles; Injections, Intraventricular; Male; Maze Learning; Mice; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Female; Immunohistochemistry; Male; Neurokinin A; Rats; Rats, Wistar; Substance P; Trigeminal Ganglion; Trigeminal Nucleus, Spinal | 2000 |
A comparison of four extraction methods for substance P, neurokinin A and calcitonin gene-related peptide from human dental pulp tissue.
Topics: Acetic Acid; Adolescent; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Hot Temperature; Humans; Neurokinin A; Neuropeptides; Radioimmunoassay; Substance P | 1999 |
Tachykinin activation of human monocytes from patients with interstitial lung disease, healthy smokers or healthy volunteers.
Topics: Adult; Aged; Cells, Cultured; Female; Humans; Lung Diseases, Interstitial; Male; Middle Aged; Monocytes; Neurokinin A; Peptide Fragments; Pulmonary Fibrosis; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Reference Values; Sarcoidosis; Smoking; Substance P; Superoxides; Tachykinins | 2000 |
Role of nitric oxide and septide-insensitive NK(1) receptors in bronchoconstriction induced by aerosolised neurokinin A in guinea-pigs.
Topics: Aerosols; Airway Resistance; Animals; Bronchoconstriction; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 2000 |
Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists.
Topics: Animals; Benzamides; Indoles; Isoindoles; Male; Microinjections; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Substance P; Tachykinins; Tidal Volume | 2000 |
Respiratory actions of tachykinins in the nucleus of the solitary tract: effect of neonatal capsaicin pretreatment.
Topics: Animals; Animals, Newborn; Capsaicin; Male; Microinjections; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Rats, Wistar; Respiratory Mechanics; Solitary Nucleus; Substance P; Tachykinins | 2000 |
Further evidence for the presence of "septide-sensitive" tachykinin binding sites in tissues possessing solely NK(1) tachykinin receptors.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Humans; Indoles; Iodine Radioisotopes; Isoindoles; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protein Isoforms; Pyrrolidonecarboxylic Acid; Radioligand Assay; Rats; Receptors, Neurokinin-1; Substance P; Tetrazoles; Tumor Cells, Cultured | 2000 |
Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors.
Topics: Animals; Capsaicin; Electric Stimulation; Glucagon; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Nerve Fibers; Neurokinin A; Pancreas; Receptors, Neurokinin-1; Somatostatin; Substance P; Swine; Tachykinins; Vagus Nerve | 2000 |
Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists.
Topics: Animals; Diestrus; Estrogens; Estrus; Female; Metestrus; Neurokinin A; Ovariectomy; Peptide Fragments; Piperidines; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Uterine Contraction | 2000 |
Activation of neurokinin NK(2) receptors by tachykinin peptides causes contraction of uterus in pregnant women near term.
Topics: Adult; Analysis of Variance; Female; Humans; In Vitro Techniques; Neurokinin A; Neurokinin B; Pregnancy; Pregnancy Trimester, Third; Protease Inhibitors; Receptors, Neurokinin-2; Substance P; Tachykinins; Uterine Contraction | 2000 |
Alterations of intestinal motor responses to various stimuli after Nippostrongylus brasiliensis infection in rats: role of mast cells.
Topics: Animals; Carbachol; Cholinergic Agonists; Food; Gastrointestinal Motility; Jejunal Diseases; Male; Mastocytosis; Myoelectric Complex, Migrating; Neurokinin A; Nippostrongylus; Rats; Rats, Wistar; Strongylida Infections; Substance P | 2000 |
Distribution of neuropeptides, histamine content, and inflammatory cells in the ureter.
Topics: Animals; Bradykinin; Histamine; Leukocytes; Mast Cells; Neurokinin A; Substance P; Swine; Ureter | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
N-[(R,R)-(E)-1-(4-chloro-benzyl)-3-(2-oxo-azepan-3-ylcarbamoyl)-allyl]-N-methyl-3,5-bis-trifluoromethyl-benzamide: an orally active neurokinin NK1/NK2 antagonist.
Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Aza Compounds; Benzamides; Bronchoconstriction; Drug Design; Guinea Pigs; Molecular Structure; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-2; Stereoisomerism; Substance P | 2000 |
Carboxypeptidase-mediated metabolism of calcitonin gene-related peptide in human gingival crevicular fluid--a rôle in periodontal inflammation?
Topics: Adult; Calcitonin Gene-Related Peptide; Carboxypeptidases; Case-Control Studies; Female; Gingival Crevicular Fluid; Humans; Hydrolysis; Male; Neurogenic Inflammation; Neurokinin A; Periodontitis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substance P | 2000 |
Changes in substance P and neurokinin A in gingival crevicular fluid in response to periodontal treatment.
Topics: Adult; Aged; Dental Scaling; Female; Gingival Crevicular Fluid; Humans; Male; Middle Aged; Neurogenic Inflammation; Neurokinin A; Periodontal Index; Periodontitis; Radioimmunoassay; Statistics, Nonparametric; Substance P; Tachykinins | 2000 |
Different subtypes of tachykinin NK(1) receptor binding sites are present in the rat brain.
Topics: Amygdala; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cerebral Cortex; Iodine Radioisotopes; Kinetics; Male; Neurokinin A; Protein Isoforms; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins | 2000 |
Tachykininergic excitatory neurotransmission in the pig intravesical ureter.
Topics: Animals; Female; Immunohistochemistry; In Vitro Techniques; Male; Neurokinin A; Substance P; Swine; Ureter | 2000 |
Independent endocytosis of the NK(1) and NK(3) tachykinin receptors in neurons of the rat myenteric plexus.
Topics: Animals; Endocytosis; Female; Male; Monensin; Myenteric Plexus; Neurokinin A; Neurons; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 2000 |
[The neurogenic mechanisms of ocular inflammation and their modulation under local treatment with indomethacin].
Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Capillary Permeability; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indomethacin; Inflammation; Neurokinin A; Neurokinin B; Rabbits; Substance P | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Time Factors | 2000 |
Differential role of neurokinin receptors in human lymphocyte and monocyte chemotaxis.
Topics: Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Indoles; Inflammation; Monocytes; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; T-Lymphocytes | 2000 |
The common C-terminal sequences of substance P and neurokinin A contact the same region of the NK-1 receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; CHO Cells; Conserved Sequence; Cricetinae; Inhibitory Concentration 50; Ligands; Mutation; Neurokinin A; Peptide Mapping; Photoaffinity Labels; Protein Binding; Protein Conformation; Receptors, Neurokinin-1; Substance P; Transfection; Trypsin | 2000 |
Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs.
Topics: Administration, Inhalation; Airway Resistance; Animals; Bradykinin; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Capsaicin; Guinea Pigs; Histamine; Leukocyte Count; Lung; Male; Methacholine Chloride; Neurokinin A; Ovalbumin; Peptide Fragments; Smoking; Substance P; Wakefulness | 2001 |
Effects of natural tachykinins on porcine lower urinary tract smooth muscle.
Topics: Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Swine; Urinary Bladder | 2000 |
Tachykinins contribute to nerve-mediated contractions in the human esophagus.
Topics: Atropine; Autonomic Nervous System; Benzamides; Dose-Response Relationship, Drug; Esophagus; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Parasympatholytics; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Effect of tachykinins on airway function in cynomolgus monkeys.
Topics: Administration, Inhalation; Airway Resistance; Animals; Bronchoconstriction; Dose-Response Relationship, Drug; Infusions, Intravenous; Lung Compliance; Macaca fascicularis; Male; Neurokinin A; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2001 |
Tachykinin NK(2) receptor mediates contraction and ion transport in rat colon by different mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Indomethacin; Intestinal Mucosa; Ion Transport; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P | 2001 |
Capsaicin pre- and post-treatment on rat monocrotaline pneumotoxicity.
Topics: Animals; Capsaicin; Functional Residual Capacity; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Neprilysin; Neurokinin A; Organ Size; Rats; Rats, Sprague-Dawley; Substance P; Total Lung Capacity | 2000 |
Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanat
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Female; Functional Laterality; Headache; Male; Neurokinin A; Pain; Rats; Rats, Wistar; Substance P; Trigeminal Ganglion; Trigeminal Nucleus, Spinal | 2001 |
Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Intracellular Fluid; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P; Tetrazoles | 2001 |
Tachykinin activation of human monocytes from patients with rheumatoid arthritis: in vitro and ex-vivo effects of cyclosporin A.
Topics: Arthritis, Rheumatoid; Carcinogens; Cells, Cultured; Cyclosporine; Humans; Immunosuppressive Agents; In Vitro Techniques; Monocytes; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Burst; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
NK2 tachykinin receptors mediate contraction of the pig intravesical ureter: tachykinin-induced enhancement of non-adrenergic non-cholinergic excitatory neurotransmission.
Topics: Animals; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Tonus; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Substance P; Swine; Synaptic Transmission; Ureter | 2001 |
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcitonin Gene-Related Peptide; Capsaicin; Diclofenac; Duodenum; Gastric Mucins; Male; Misoprostol; Neurokinin A; Oligopeptides; Peptides; Protease Inhibitors; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Thrombin; Saliva; Stomach; Substance P | 2001 |
Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus.
Topics: Animals; Antiemetics; Brain Stem; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; Neurokinin A; Patch-Clamp Techniques; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Presynaptic; Substance P; Tetrodotoxin; Vagus Nerve | 2001 |
An animal model to assess aversion to intra-oral capsaicin: increased threshold in mice lacking substance p.
Topics: Administration, Oral; Animals; Capsaicin; Drug Tolerance; Irritants; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Neurokinin A; Protein Precursors; Species Specificity; Substance P; Tachykinins; Taste Threshold | 2001 |
Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue.
Topics: Animals; Binding, Competitive; Indoles; Iodine Radioisotopes; Isoindoles; Membranes; Neurokinin A; Neurokinin-1 Receptor Antagonists; Phenylalanine; Photoaffinity Labels; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Salivation; Submandibular Gland; Substance P | 2001 |
Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo.
Topics: Adrenocorticotropic Hormone; Animals; Carbachol; Colon; Corticotropin-Releasing Hormone; Defecation; Denervation; Gerbillinae; Male; Muscarinic Agonists; Naphthyridines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Restraint, Physical; Serotonin; Stress, Psychological; Substance P | 2001 |
Involvement of neuropeptides in the allergic nasal obstruction in guinea pigs.
Topics: Animals; Calcitonin Gene-Related Peptide; Guinea Pigs; Hypersensitivity; Male; Miotics; Nasal Cavity; Nasal Obstruction; Neurokinin A; Neuropeptides; Peptide Fragments; Rhinitis; Substance P | 2001 |
Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum.
Topics: Animals; Cerebral Cortex; Delayed-Action Preparations; Estradiol; Female; Hippocampus; Neostriatum; Neurokinin A; Neuropeptide Y; Neurotensin; Norethindrone; Ovariectomy; Progesterone; Progesterone Congeners; Radioimmunoassay; Rats; Substance P; Tachykinins | 2001 |
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.
Topics: Animals; Antidiarrheals; Capsaicin; Colitis, Ulcerative; Colon; Crohn Disease; Epithelial Cells; Food Hypersensitivity; Guinea Pigs; Humans; Immunoglobulin E; Inflammatory Bowel Diseases; Male; Mast Cells; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P; Tachykinins | 2001 |
Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blepharitis; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Cells, Cultured; Drug Synergism; Female; Ganglia, Spinal; Guinea Pigs; Inflammation; Lectins; Male; Neurokinin A; Neurons; Plant Extracts; Plant Lectins; Rats; Ricinoleic Acids; Seeds; Substance P | 2001 |
Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, P-Type; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Guanosine Diphosphate; In Vitro Techniques; Neurokinin A; omega-Conotoxin GVIA; Pain; Patch-Clamp Techniques; Phosphinic Acids; Posterior Horn Cells; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Thionucleotides | 2001 |
Large veins in the Atlantic cod (Gadus morhua) and the rainbow trout (Oncorhynchus mykiss) are innervated by neuropeptide-containing nerves.
Topics: Animals; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Galanin; Muscle, Smooth, Vascular; Nerve Fibers; Neurokinin A; Neuropeptides; Nitric Oxide Synthase; Oncorhynchus mykiss; Pituitary Adenylate Cyclase-Activating Polypeptide; Substance P; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide; Veins | 2001 |
Effect of calcitonin gene-related peptide (CGRP) on motility and on the release of substance P, neurokinin A, somatostatin and gastrin in the isolated perfused porcine antrum.
Topics: Animals; Calcitonin Gene-Related Peptide; Gastrins; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Neurokinin A; Perfusion; Pyloric Antrum; Somatostatin; Substance P; Swine | 2001 |
Effects of natural tachykinins on ovine lower urinary tract smooth muscle.
Topics: Animals; Eledoisin; Female; Guinea Pigs; In Vitro Techniques; Kassinin; Male; Muscle, Smooth; Neurokinin A; Peptides, Cyclic; Receptors, Neurokinin-2; Sheep; Substance P; Tachykinins; Urinary Tract | 2001 |
Radioligand binding and functional characterisation of tachykinin receptors in chicken small intestine.
Topics: Animals; Binding, Competitive; Chickens; Female; In Vitro Techniques; Intestine, Small; Neurokinin A; Peptide Fragments; Radioligand Assay; Radiopharmaceuticals; Receptors, Tachykinin; Substance P; Succinimides | 2001 |
Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene.
Topics: Acetic Acid; Animals; Cell Count; Indicators and Reagents; Irritants; Mice; Mice, Knockout; Neurokinin A; Neurons; Peptides, Cyclic; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-2; Spinal Cord; Stimulation, Chemical; Substance P; Tachykinins; Urinary Bladder; Urinary Incontinence; Urination | 2001 |
Acinar degranulation in the rat parotid gland induced by neuropeptides.
Topics: Amylases; Animals; Body Fluids; Cell Degranulation; Female; Neurokinin A; Neuropeptides; Parotid Gland; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide | 2001 |
The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor.
Topics: Animals; Capsaicin; Cell Line, Transformed; Epidermis; Female; Humans; Keratinocytes; Mice; Mice, Inbred BALB C; Nerve Growth Factor; Neurokinin A; Neuropeptides; RNA, Messenger; Substance P; Up-Regulation | 2001 |
Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.
Topics: Acetylcholine; Aged; Benzamides; Bronchi; Cholinergic Fibers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Neurokinin A; Piperidines; Protein Precursors; Radioimmunoassay; Receptors, Neurokinin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Vasodilator Agents | 2001 |
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central Nervous System; Citric Acid; Cloning, Molecular; Cough; Guinea Pigs; In Vitro Techniques; Iris; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pupil; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin; Recombinant Proteins; Substance P | 2002 |
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P | 2001 |
A yeast artificial chromosome containing the human preprotachykinin-A gene expresses substance P in mice and drives appropriate marker-gene expression during early brain embryogenesis.
Topics: Amygdala; Animals; Brain; Chromosomes, Artificial, Yeast; Corpus Striatum; Female; Ganglia, Spinal; Gene Expression Regulation, Developmental; Genetic Markers; Hippocampus; Humans; Lac Operon; Male; Mesencephalon; Mice; Mice, Knockout; Neurokinin A; Pregnancy; Protein Precursors; Protein Processing, Post-Translational; Rhombencephalon; RNA Splicing; Spinal Cord; Substance P; Tachykinins; Transcription, Genetic | 2002 |
Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats.
Topics: Alcohol Drinking; Animals; Cerebral Cortex; Hypothalamus; Male; Neurokinin A; Neurokinin B; Rats; Species Specificity; Substance P | 2001 |
Evaluation of tachykinins and their receptors to determine sensory innervation in the dorsal hoof wall and insertion of the distal sesamoidean impar ligament and deep digital flexor tendon on the distal phalanx in healthy feet of horses.
Topics: Animals; Foot; Hoof and Claw; Horses; Immunohistochemistry; Ligaments; Microcirculation; Neurokinin A; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins; Tendons | 2002 |
Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Female; Humans; Male; Middle Aged; Neurokinin A; Pain Measurement; Pulpitis; Radioimmunoassay; Regression Analysis; Smoking; Statistics as Topic; Substance P; Toothache | 2002 |
Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Electromyography; Gastrointestinal Motility; Intestine, Small; Neurokinin A; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins | 2002 |
Effect of tachykinins on ascending and descending reflex pathway in rat small intestine.
Topics: Afferent Pathways; Animals; Biphenyl Compounds; Efferent Pathways; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Reaction Time; Receptors, Neurokinin-2; Reflex; Substance P; Tachykinins | 2002 |
Role of tachykinins in sephadex-induced airway hyperreactivity and inflammation in guinea pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cell Count; Cyclohexylamines; Dextrans; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Indoles; Inflammation; Macrophages; Male; Neurokinin A; Peptides, Cyclic; Receptors, Tachykinin; Substance P; Tachykinins; Time Factors; Vasodilator Agents | 2002 |
Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs.
Topics: Action Potentials; Animals; Guinea Pigs; Immunohistochemistry; Male; Neural Conduction; Neurokinin A; Neurons, Afferent; Nodose Ganglion; Respiratory Tract Infections; Respirovirus Infections; Sendai virus; Substance P; Trachea | 2002 |
In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum.
Topics: Animals; Extracellular Space; Leucine; Male; Neostriatum; Neurokinin A; Neurons; Neuropeptides; Peptide Fragments; Proline; Protease Inhibitors; Protein Structure, Tertiary; Rats; Rats, Wistar; Subcellular Fractions; Substance P; Tachykinins; Tritium | 2002 |
Effect of monensin on the levels of tachykinins and their processing enzyme activity in rat dorsal root ganglia.
Topics: Animals; Carboxypeptidase H; Carboxypeptidases; Ganglia, Spinal; Ionophores; Male; Monensin; Neurokinin A; Organ Culture Techniques; Rats; Rats, Wistar; Substance P | 2002 |
The neurokinin-2 receptor is not involved in the sensitization of primary afferents of the rat knee joint.
Topics: Animals; Knee Joint; Male; Mechanoreceptors; Nerve Fibers; Neurokinin A; Neurons, Afferent; Pain; Peptide Fragments; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-2; Rotation; Substance P | 2002 |
Age differences in neurokinin A and substance P from the hypothalamus, pituitary, pineal gland, and striatum of the rat. Effect of exogenous melatonin.
Topics: Aging; Animals; Female; Hypothalamus; Injections, Subcutaneous; Melatonin; Neostriatum; Neurokinin A; Pineal Gland; Pituitary Gland; Rats; Rats, Wistar; Substance P | 2002 |
CO(2)-induced c-Fos expression in brainstem preprotachykinin mRNA containing neurons.
Topics: Animals; Carbon Dioxide; Chemoreceptor Cells; Gene Expression; Hypercapnia; Male; Neurokinin A; Neurons; Protein Precursors; Proto-Oncogene Proteins c-fos; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Center; RNA, Messenger; Substance P; Tachykinins | 2002 |
Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth.
Topics: Adolescent; Adult; Age Factors; Aged; Calcitonin Gene-Related Peptide; Case-Control Studies; Chi-Square Distribution; Dental Pulp; Female; Follow-Up Studies; Gingival Crevicular Fluid; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neurokinin A; Periodontal Index; Pulpectomy; Pulpitis; Radioimmunoassay; Sex Factors; Statistics as Topic; Statistics, Nonparametric; Substance P | 2002 |
Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease.
Topics: Adult; Aged; Autoradiography; Colon; Colon, Sigmoid; Diverticulitis; Female; Humans; Indomethacin; Kinetics; Male; Middle Aged; Muscle, Smooth; Neurokinin A; Organ Specificity; Receptors, Neurokinin-1; Reference Values; Substance P | 2002 |
Mutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses.
Topics: Calcium; Cyclic AMP; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Models, Theoretical; Mutation; Neurokinin A; Protein Conformation; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Structure-Activity Relationship; Substance P | 2002 |
The primary structures and myotropic activities of two tachykinins isolated from the African clawed frog, Xenopus laevis.
Topics: Amino Acid Sequence; Animals; Atropine; Bufo marinus; Immunohistochemistry; Intestines; Methysergide; Muscle, Smooth; Nerve Fibers; Neurokinin A; Sequence Homology, Amino Acid; Stomach; Substance P; Tachykinins; Tetrodotoxin; Xenopus laevis | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Ozone-induced release of neuropeptides from human nasal mucosa cells.
Topics: Biopsy; Culture Techniques; Humans; Immunoenzyme Techniques; Immunohistochemistry; Microscopy, Confocal; Nasal Mucosa; Neurokinin A; Ozone; Rhinitis, Allergic, Perennial; Statistics, Nonparametric; Substance P | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Motor Activity; Neurokinin A; Neurosurgical Procedures; Olfactory Bulb; Smell; Social Behavior; Spatial Behavior; Stress, Physiological; Substance P | 2002 |
Neurokinin-receptor-mediated depolarization of cortical neurons elicits an increase in glutamate release at excitatory synapses.
Topics: Action Potentials; Animals; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Interneurons; Male; Neurokinin A; Neurokinin B; Patch-Clamp Techniques; Peptide Fragments; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Synapses; Tetrodotoxin | 2002 |
Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Neurokinin A; Neurokinin B; Presynaptic Terminals; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Solitary Nucleus; Substance P; Synaptic Transmission; Vagus Nerve; Visceral Afferents | 2002 |
Human bone marrow angiogenesis: in vitro modulation by substance P and neurokinin A.
Topics: Angiogenesis Inducing Agents; Bone Marrow; Bone Marrow Cells; Cell Culture Techniques; Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Microcirculation; Neovascularization, Physiologic; Nerve Fibers; Neurokinin A; Substance P | 2002 |
Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Indoles; Injections, Spinal; Isoindoles; Male; Mice; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P | 2003 |
[Study on the determination of peptide mixture by HPCE].
Topics: Angiotensin I; Angiotensin II; Angiotensin III; Electrophoresis, Capillary; Neurokinin A; Peptides; Somatostatin; Substance P | 2000 |
A tachykinin-like factor increases glutamate toxicity in rat cerebellar granule cells.
Topics: Animals; Antibodies; Cells, Cultured; Cerebellum; Glutamic Acid; Neurokinin A; Neurokinin B; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Tachykinins | 2003 |
Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Capsaicin; Enzyme-Linked Immunosorbent Assay; Gene Deletion; Gene Expression Regulation; Hematopoietic Stem Cells; Immune System; Inflammation; Ligands; Lung; Mice; Mice, Transgenic; Neurokinin A; Neurons; Protein Precursors; Respiration; Substance P; Tachykinins; Time Factors; Trachea | 2003 |
Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes.
Topics: Animals; Calcium Signaling; Colon; Electric Conductivity; Imidazoles; Indoles; Male; Maleimides; Membrane Potentials; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Myocytes, Smooth Muscle; Neurokinin A; Nicardipine; Patch-Clamp Techniques; Peptide Fragments; Peptides; Physalaemin; Receptors, Tachykinin; Ryanodine; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems; Substance P | 2003 |
Pharmacological properties of peptides derived from an antibody against the tachykinin NK1 receptor for the neuropeptide substance P.
Topics: Animals; Antibody Formation; Autoradiography; Cattle; Complementarity Determining Regions; Cyclic AMP; Inositol Phosphates; Neurokinin A; Peptide Biosynthesis; Peptide Fragments; Radioligand Assay; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2003 |
A role for tachykinins in female mouse and rat reproductive function.
Topics: Animals; Capsaicin; Embryo, Mammalian; Female; Fertility; Gene Expression Regulation; Litter Size; Male; Mice; Neprilysin; Neurokinin A; Neurokinin B; Oocytes; Ovary; Pregnancy; Protein Precursors; Rats; Rats, Wistar; Receptors, Tachykinin; RNA, Messenger; Spermatozoa; Substance P; Tachykinins; Uterus | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2003 |
Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration.
Topics: Animals; Animals, Newborn; Autoradiography; Brain Stem; Capsaicin; Indicators and Reagents; Iodine Radioisotopes; Neurokinin A; Peptide Fragments; Rats; Receptors, Tachykinin; Substance P; Succinimides | 2003 |
Biologic activity of the tachykinins on lamb and sheep gallbladder.
Topics: Animals; Binding Sites; Capsaicin; Dose-Response Relationship, Drug; Female; Gallbladder; Male; Muscles; Neurokinin A; Neurokinin B; Peptide Fragments; Physalaemin; Protein Structure, Tertiary; Pyrrolidonecarboxylic Acid; Receptors, Tachykinin; Sheep; Substance P; Tachykinins | 2003 |
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan | 2003 |
Functional development of neurokinin peptides substance P and neurokinin A in nociception.
Topics: Animals; Animals, Newborn; Female; Male; Mice; Mice, Knockout; Neurokinin A; Pain Measurement; Protein Precursors; Receptors, Neurokinin-1; Substance P; Tachykinins | 2003 |
Role of sensory nerve peptides rather than mast cell histamine in paclitaxel hypersensitivity.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Hypersensitivity; Histamine; Immunohistochemistry; Infusions, Intravenous; Male; Mast Cells; Neurokinin A; Neuropeptides; Paclitaxel; Probability; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sensory Receptor Cells; Substance P | 2004 |
Miniaturization of fluorescence polarization receptor-binding assays using CyDye-labeled ligands.
Topics: Animals; Atropine; Binding, Competitive; Carbocyanines; CHO Cells; Cricetinae; Fluorescence Polarization; Fluorescent Dyes; Humans; Kinetics; Miniaturization; Neurokinin A; Peptides; Pirenzepine; Receptors, Cell Surface; Receptors, Muscarinic; Receptors, Neurokinin-1; Sensitivity and Specificity; Substance P | 2003 |
Similarities of SP-, NKA- and NKB-induced currents in rat dorsal root ganglion neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA; Substance P; Tachykinins | 2003 |
Natural killer cell functions mediated by the neuropeptide substance P.
Topics: Chemotaxis; Cytotoxicity, Immunologic; Humans; K562 Cells; Killer Cells, Natural; Neurokinin A; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P | 2003 |
Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord.
Topics: Aminopeptidases; Animals; Electric Stimulation; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Microscopy, Confocal; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Spinal Nerve Roots; Substance P | 2003 |
Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo.
Topics: Animals; Electrophysiology; Genotype; Hot Temperature; Male; Mice; Mice, Knockout; Mustard Plant; Nerve Fibers, Unmyelinated; Neurokinin A; Neurons; Plant Extracts; Plant Oils; Posterior Horn Cells; Protein Precursors; Spinal Cord; Substance P; Tachykinins | 2004 |
Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits.
Topics: Animals; Arterioles; Blood-Retinal Barrier; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Male; Microinjections; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neuropeptides; Optic Nerve; Peptide Fragments; Rabbits; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Retinal Vessels; Substance P; Sumatriptan; Vasodilation | 2004 |
[Effect of substance P, neurokinin A and a selective agonist of tachykinin receptors of the NK-2 type on bile metabolism].
Topics: Animals; Bile; Hepatocytes; Male; Neurokinin A; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins | 2003 |
Circular versus longitudinal myometrial contractile response to selective tachykinin receptor agonists in rat.
Topics: Animals; Female; Myometrium; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Uterine Contraction; Uterus | 2003 |
Influence of maturation on constrictive response to stimulation of C-fiber afferents in isolated guinea pig airways.
Topics: Aging; Animals; Bronchi; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Nerve Fibers, Unmyelinated; Neurokinin A; Neurons, Afferent; Osmolar Concentration; Radioimmunoassay; Stimulation, Chemical; Substance P; Trachea; Vasoconstriction | 2004 |
Neurotrophin receptors and enteric neuronal development during metamorphosis in the amphibian Xenopus laevis.
Topics: Animals; Apoptosis; Enteric Nervous System; Intestines; Larva; Metamorphosis, Biological; Neurokinin A; Receptors, Nerve Growth Factor; Regeneration; Substance P; Vasoactive Intestinal Peptide; Xenopus laevis | 2004 |
Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Hypersensitivity; Male; Neurokinin A; Neuropeptides; Paclitaxel; Pyridines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Substance P | 2004 |
Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion.
Topics: Animals; Capsaicin; Colforsin; Colon; Electric Stimulation; Electrophysiology; Guinea Pigs; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Naphthyridines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Statistics, Nonparametric; Substance P; Tetrodotoxin | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Seasonal changes of SP and NKA in frontal cortex, striatum and testes in the rat. Role of maternal pineal gland.
Topics: Animals; Brain; Female; Frontal Lobe; Male; Melatonin; Neostriatum; Neurokinin A; Pineal Gland; Pregnancy; Rats; Rats, Wistar; Seasons; Substance P; Testis | 2004 |
Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Respiratory Hypersensitivity; Severity of Illness Index; Substance P | 2004 |
Modulation of tachykinin and cytokine release in patients with coronary disease undergoing percutaneous revascularization.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Artery Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interferon-gamma; Male; Middle Aged; Neurokinin A; Substance P; Tumor Necrosis Factor-alpha | 2004 |
Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.
Topics: Animals; Binding Sites; Cardia; Dose-Response Relationship, Drug; Eledoisin; Female; Indoles; Intercellular Signaling Peptides and Proteins; Intestine, Small; Iodine Radioisotopes; Isoindoles; Kassinin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Physalaemin; Receptors, Tachykinin; Species Specificity; Substance P; Xenopus | 2004 |
Neurokinin-1 receptors in the rat nucleus tractus solitarius: pre- and postsynaptic modulation of glutamate and GABA release.
Topics: Afferent Pathways; Animals; Dendrites; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Interneurons; Male; Neural Inhibition; Neurokinin A; Neuropeptides; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sodium Channel Blockers; Solitary Nucleus; Substance P; Synapses; Synaptic Transmission | 2004 |
Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.
Topics: Amides; Animals; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Neurokinin A; Pyridines; Rats; Rats, Wistar; Substance P; Urinary Bladder | 2004 |
Influence of maternal pineal gland on the developmental pattern of neurokinin A (NKA) and substance P (SP) in male-rat-offspring: relationship to the season of the year.
Topics: Animals; Female; Frontal Lobe; Male; Maternal-Fetal Exchange; Neurokinin A; Pineal Gland; Pregnancy; Rats; Rats, Wistar; Seasons; Substance P; Testis | 2004 |
Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Calcium; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Humans; Inositol Phosphates; Intracellular Space; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin A; Peptides, Cyclic; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Sequence Homology, Amino Acid; Substance P; Transfection; Tritium | 2004 |
Immunohistochemical distribution of tachykinins in the CNS of the lamprey Petromyzon marinus.
Topics: Animals; Antibodies; Antibody Specificity; Axons; Brain; Brain Mapping; Immunohistochemistry; Neural Pathways; Neurokinin A; Neurons; Petromyzon; Spinal Cord; Substance P; Tachykinins | 2004 |
Effect of neurokinins on canine prostate cell physiology.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Differentiation; Cell Division; Cells, Cultured; Dogs; Epithelial Cells; Fibroblasts; Immunohistochemistry; Male; Muscle, Smooth; Neurokinin A; Prostate; Quinolines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stromal Cells; Substance P; Tritium | 2005 |
Neurokinin a is a main constituent of sensory neurons innervating the anterior segment of the eye.
Topics: Aged; Aged, 80 and over; Animals; Animals, Newborn; Anterior Eye Segment; Calcitonin Gene-Related Peptide; Capsaicin; Chromatography, High Pressure Liquid; Female; Fluorescent Antibody Technique, Indirect; Humans; In Situ Hybridization; Male; Middle Aged; Neurokinin A; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins; Trigeminal Ganglion | 2005 |
[The simultaneous analysis of substance P, somatostatin, neurokinin and neurotensin by capillary zone electrophoresis].
Topics: Electrophoresis, Capillary; Humans; Neurokinin A; Neurotensin; Somatostatin; Substance P | 1997 |
Mapping of tachykinins in the cat spinal cord.
Topics: Animals; Antibody Specificity; Brain Mapping; Cats; Cell Shape; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Neurons; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Species Specificity; Spinal Cord; Substance P; Synaptic Transmission; Tachykinins | 2005 |
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2005 |
Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Inositol Phosphates; Iodine Radioisotopes; Ligands; Morpholines; Mutation, Missense; Neurokinin A; Phthalic Acids; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Substance P; Tritium | 2005 |
Tachykinins and tachykinin-receptors in the rat pineal gland.
Topics: Animals; Dendritic Cells; DNA Primers; Immunohistochemistry; Macrophages; Male; Neurokinin A; Pineal Gland; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Tachykinin; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Tachykinins | 2005 |
Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways.
Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Animal; Female; Immunohistochemistry; Leukocyte Count; Mice; Mice, Inbred BALB C; Neurokinin A; Neurons, Afferent; Ovalbumin; Respiratory Hypersensitivity; Substance P; Tachykinins; Vagus Nerve | 2005 |
Involvement of Ca2+ signaling in tachykinin-mediated contractile responses in swine trachea.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Carbachol; Cytosol; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Substance P; Swine; Tachykinins; Trachea | 2005 |
Two major tachykinins, substance P and substance K, are localized to distinct subsets of amacrine cells in the anuran retina.
Topics: Amacrine Cells; Animals; Anura; Cell Shape; Dendrites; Female; Male; Neural Pathways; Neurokinin A; Substance P; Synapses; Synaptic Transmission; Vision, Ocular | 2005 |
The anti-proliferative effect of neurokinin-A on hematopoietic progenitor cells is partly mediated by p53 activating the 5' flanking region of neurokinin-2 receptor.
Topics: 5' Flanking Region; Cell Line, Tumor; Cell Proliferation; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; K562 Cells; Neurokinin A; Receptors, Neurokinin-2; RNA, Messenger; Signal Transduction; Substance P; Tumor Suppressor Protein p53 | 2006 |
Substance P, neurokinins A and B, and synthetic tachykinin peptides protect mesencephalic dopaminergic neurons in culture via an activity-dependent mechanism.
Topics: Animals; Calcium Channels, N-Type; Cell Count; Cell Survival; Dopamine; Ion Channel Gating; Mesencephalon; Neurokinin A; Neurokinin B; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Sodium Channels; Substance P; Tetrodotoxin | 2005 |
Endobronchial adenosine monophosphate challenge causes tachykinin release in the human airway.
Topics: Adenosine Monophosphate; Adult; Bronchi; Calcitonin Gene-Related Peptide; Female; Humans; Male; Neurokinin A; Substance P; Tachykinins | 2005 |
Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.
Topics: Animals; Hypothalamo-Hypophyseal System; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vasopressins | 2005 |
[Effect of natural tachykinins on the bile production in rats].
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Liver; Neurokinin A; Neurokinin B; Phospholipids; Rats; Solubility; Substance P; Tachykinins | 2005 |
Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cyclohexylamines; Female; Humans; Indoles; Mice; Mice, Nude; Molecular Structure; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Xenograft Model Antitumor Assays | 2005 |
Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats.
Topics: Alcohol Drinking; Animals; Body Weight; Brain Chemistry; Male; Neurokinin A; Radioimmunoassay; Rats; Rats, Wistar; Social Isolation; Substance P; Tachykinins | 2005 |
Role of NK1 and NK2 receptors in mouse gastric mechanical activity.
Topics: Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2006 |
Substance P initiates NFAT-dependent gene expression in spinal neurons.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Hippocampus; Indoles; Neurokinin A; Neurons, Afferent; NFATC Transcription Factors; Nimodipine; Phorbol 12,13-Dibutyrate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Spleen; Substance P; Tacrolimus | 2006 |
Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp.
Topics: Adult; Calcitonin Gene-Related Peptide; Dental Pulp; Dental Pulp Exposure; Humans; Neurokinin A; Neuropeptide Y; Neuropeptides; Pulpitis; Substance P; Vasoactive Intestinal Peptide | 2006 |
Tachykinin receptor expression and function in human esophageal smooth muscle.
Topics: Calcium; Calcium Channels, L-Type; Cell Separation; Cholinergic Agonists; Electrophysiology; Esophagus; Fluorescent Antibody Technique; Humans; Ion Channels; Muscle, Smooth; Neurokinin A; Neurokinin B; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Substance P; Tetrodotoxin | 2006 |
The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye.
Topics: Anesthetics, Local; Animals; Atropine; Autonomic Pathways; Carbachol; Cholinergic Fibers; Cocaine; Inflammation; Iris; Lidocaine; Male; Neurokinin A; Optic Nerve; Parasympathetic Nervous System; Rabbits; Substance P | 2006 |
Neurokinin A and neurokinin B in the human retina.
Topics: Chromatography, High Pressure Liquid; Fluorescent Antibody Technique; Humans; Neurokinin A; Neurokinin B; Radioimmunoassay; Retina; Substance P | 2006 |
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
Topics: Animals; Animals, Newborn; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebral Palsy; Excitatory Amino Acid Agonists; Female; Ibotenic Acid; Immunohistochemistry; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Neprilysin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Protease Inhibitors; Receptors, Neurokinin-2; Seizures; Substance P; Thiorphan | 2006 |
The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosus.
Topics: Acclimatization; Alligators and Crocodiles; Animals; Calcitonin Gene-Related Peptide; Fresh Water; Immunohistochemistry; Neurokinin A; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Salt Gland; Seawater; Substance P; Tubulin | 2007 |
Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons.
Topics: Animals; Female; Hot Temperature; Male; Mice; Mice, Knockout; Neurokinin A; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Spinal Cord Injuries; Substance P | 2007 |
Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction.
Topics: Adolescent; Adult; Asthma, Exercise-Induced; Child; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Leukotrienes; Male; Middle Aged; Mucin 5AC; Mucins; Neurokinin A; Reverse Transcriptase Polymerase Chain Reaction; Sputum; Substance P | 2007 |
Neurokinins enhance excitability in capsaicin-responsive DRG neurons.
Topics: Action Potentials; Animals; Capsaicin; Electric Stimulation; Enzyme Activation; Ganglia, Spinal; Intracellular Membranes; Male; Neurokinin A; Neurons, Afferent; Patch-Clamp Techniques; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Neurokinin-2; Signal Transduction; Substance P; Tachykinins | 2007 |
A role for tachykinins in the regulation of human sperm motility.
Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression: implications for the pathophysiology of depression.
Topics: Adrenal Glands; Animals; Anxiety, Separation; Body Weight; Corticotropin-Releasing Hormone; Depression; Entorhinal Cortex; Immunochemistry; Male; Neurokinin A; Occipital Lobe; Organ Size; Periaqueductal Gray; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Social Isolation; Substance P | 2008 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Intraluminal acid induces oesophageal shortening via capsaicin-sensitive neurokinin neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Esophagus; Female; Gastric Acid; Male; Models, Biological; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons, Afferent; Opossums; Peptide Fragments; Receptors, Neurokinin-2; Substance P; Tissue Culture Techniques | 2007 |
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor.
Topics: Amino Acid Substitution; Cell Line; Enzyme Activation; Genetic Vectors; Glycine; Glycosylation; Humans; Immunohistochemistry; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Lentivirus; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin A; p38 Mitogen-Activated Protein Kinases; Receptors, Neurokinin-1; Substance P | 2007 |
Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.
Topics: Animals; Atropine; Colon; Electric Stimulation; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sodium Channel Blockers; Substance P; Tetrodotoxin | 2007 |
Distribution of neuroendocrine cells in the small and large intestines of the one-humped camel (Camelus dromedarius).
Topics: Animals; Camelus; Cholecystokinin; Gastric Inhibitory Polypeptide; Gastrin-Releasing Peptide; Immunohistochemistry; Intestine, Large; Intestine, Small; Neurokinin A; Nitric Oxide Synthase Type III; Serotonin; Sincalide; Somatostatin; Substance P | 2007 |
Fluorometric immunoassay based on pH-sensitive dye-encapsulating liposomes and gramicidin channels.
Topics: Antibodies, Monoclonal; Avidin; Biotinylation; Cholesterol; Dinitrophenols; Fluoresceins; Fluorometry; Gramicidin; Hydrogen-Ion Concentration; Immunoassay; Immunoglobulin Fab Fragments; Ion Channel Gating; Liposomes; Neurokinin A; Phosphatidylcholines; Phosphatidylethanolamines; Reproducibility of Results; Sensitivity and Specificity; Substance P; Time Factors | 2007 |
Ventilatory and cardiovascular actions of centrally administered trout tachykinins in the unanesthetized trout.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Heart Rate; Male; Neurokinin A; Oncorhynchus mykiss; Oxygen Consumption; Peptide Fragments; Substance P; Tachykinins | 2007 |
Neurokinin receptors modulate the impact of uncontrollable stimulation on adaptive spinal plasticity.
Topics: Adaptation, Psychological; Animals; Electroshock; Female; Learning; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Pain; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spinal Cord; Spinal Cord Injuries; Substance P; Vocalization, Animal | 2007 |
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Foot; Gerbillinae; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2007 |
Pelviureteric peristaltic contractions in diabetic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Humans; In Vitro Techniques; Kidney Pelvis; Male; Matched-Pair Analysis; Muscle Contraction; Muscle Strength; Muscle, Smooth; Neurokinin A; Neurotransmitter Agents; Peristalsis; Rats; Rats, Wistar; Sensory System Agents; Substance P; Ureter | 2007 |
Tac1 regulation by RNA-binding protein and miRNA in bone marrow stroma: Implication for hematopoietic activity.
Topics: 3' Untranslated Regions; Adolescent; Adult; Bone Marrow; Cytosol; Down-Regulation; Genes, Reporter; Hematopoiesis; Hepatocyte Growth Factor; Humans; Interleukin-11; MicroRNAs; Neuroimmunomodulation; Neurokinin A; RNA-Binding Proteins; RNA, Messenger; Stromal Cells; Substance P; Tachykinins; Transforming Growth Factor beta1 | 2008 |
Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies.
Topics: Analysis of Variance; Animals; Hypothalamo-Hypophyseal System; In Vitro Techniques; Male; Melatonin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Vasopressins | 2007 |
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.
Topics: Boron Compounds; Calcium Signaling; Humans; Imidazoles; Inositol 1,4,5-Trisphosphate; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; RNA, Messenger; Substance P; Trachea | 2008 |
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.
Topics: Animals; Bronchi; Capillary Permeability; Capsaicin; Chlorocebus aethiops; Citric Acid; COS Cells; Cough; Cyclic S-Oxides; Dipeptides; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Inositol Phosphates; Male; Molecular Sequence Data; Morpholines; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 2008 |
[Neuroimmune regulation in children with bronchial asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Male; Neurokinin A; Substance P | 2008 |
Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder.
Topics: Acetic Acid; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Immunohistochemistry; Nerve Fibers, Unmyelinated; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urothelium | 2008 |
Neurokinin receptor modulation of respiratory activity in the rabbit.
Topics: Animals; Exhalation; Inhalation; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phrenic Nerve; Piperidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Vagotomy | 2008 |
Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.
Topics: Age Factors; Animals; Calcium; Capsaicin; Carcinogens; Cells, Cultured; Ganglia, Spinal; Male; Neurokinin A; Neurokinin B; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Peptide Fragments; Phorbol Esters; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sensory System Agents; Signal Transduction; Substance P; TRPV Cation Channels | 2008 |
Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Exocytosis; GTP-Binding Protein alpha Subunits, Gi-Go; Intercellular Signaling Peptides and Proteins; Mast Cells; Neurokinin A; Neurokinin B; Peptides; Peritoneum; Pertussis Toxin; Rats; Rats, Wistar; Substance P; Wasp Venoms | 2008 |
Important roles of tachykinins in the development of allergic nasal hyperresponsiveness in guinea-pigs.
Topics: Allergens; Animals; Disease Models, Animal; Guinea Pigs; Humans; Nasal Lavage Fluid; Nasal Obstruction; Nasal Provocation Tests; Neurokinin A; Nose; Pollen; Receptors, Neurokinin-2; Receptors, Tachykinin; Rhinitis, Allergic, Seasonal; Sneezing; Substance P; Tachykinins | 2009 |
Cod CGRP and tachykinins in coeliac artery innervation of the Atlantic cod, Gadus morhua: presence and vasoactivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Celiac Artery; Electromyography; Gadus morhua; Immunohistochemistry; Neurokinin A; Substance P; Vasodilation | 2009 |
Oxytocin release from the rat neurohypophysis into the blood: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.
Topics: Analysis of Variance; Animals; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2008 |
Functional characterisation of hemokinin-1 in mouse uterus.
Topics: Animals; Female; Mice; Mice, Inbred BALB C; Myometrium; Neurokinin A; Pregnancy; Pregnancy, Animal; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Uterus | 2008 |
High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain.
Topics: Analysis of Variance; Animals; Bone and Bones; Cytokines; Disease Models, Animal; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Female; Inflammation; Macrophages; Movement; Musculoskeletal System; Neural Conduction; Neuralgia; Neurokinin A; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Skin; Spinal Cord; Substance P; Time Factors; Upper Extremity | 2009 |
Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation.
Topics: Acetylcholine; Adult; Aged; Aging; Atropine; Colon, Sigmoid; Constipation; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Enteric Nervous System; Female; Ganglionic Stimulants; Gastrointestinal Transit; Humans; In Vitro Techniques; Kinetics; Middle Aged; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nicotinic Agonists; Prostaglandin-Endoperoxide Synthases; Receptors, Neurokinin-1; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Tetrodotoxin; Young Adult | 2009 |
An extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins, and P2X3 and TRPV1 receptors, and inhibits ATP-induced detrusor overactivity in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Female; Hypertension; Immunohistochemistry; Neurokinin A; Neurokinin B; Rats; Rats, Inbred SHR; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urination | 2009 |
Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression.
Topics: Animals; Capsaicin; Gene Expression Regulation; Male; Morphine; Neurokinin A; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Wound Healing; Wounds and Injuries | 2009 |
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
Topics: Animals; Atropine; Capsaicin; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Pyrazines; Pyridines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rectum; Substance P; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase | 2009 |
Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Esophagus; Female; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Opossums; Peptide Fragments; Receptor, PAR-2; Receptors, Neurokinin-2; Signal Transduction; Substance P; Trypsin | 2010 |
Central administration of substance P inhibits feeding behavior in chicks.
Topics: Animals; Central Nervous System Agents; Chickens; Corticosterone; Corticotropin-Releasing Hormone; Drinking Behavior; Fasting; Feeding Behavior; Male; Motor Activity; Neurokinin A; Neurokinin B; Peptide Fragments; Substance P; Time Factors; Water | 2010 |
Expression of neuropeptides and their degrading enzymes in ACD.
Topics: Adult; Analysis of Variance; Case-Control Studies; Dermatitis, Allergic Contact; Female; Humans; Immunoenzyme Techniques; Male; Neurokinin A; Neuropeptides; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Young Adult | 2010 |
Salivary and serum levels of substance P, neurokinin A and calcitonin gene related peptide in burning mouth syndrome.
Topics: Aged; Burning Mouth Syndrome; Calcitonin Gene-Related Peptide; Female; Humans; Male; Middle Aged; Neurokinin A; Saliva; Substance P | 2010 |
Secretoneurin and the tachykinins substance P and neurokinin-A/B in NMDA-induced excitotoxicity in the rat retina.
Topics: Animals; Intravitreal Injections; Male; N-Methylaspartate; Neurokinin A; Neurokinin B; Neuropeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Retina; Secretogranin II; Substance P | 2010 |
Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-).
Topics: Animals; Animals, Newborn; Brain Stem; Gene Deletion; Hypoxia; In Vitro Techniques; Mice; Morphine; Neurokinin A; Pulmonary Ventilation; Respiration; Substance P; Tachykinins | 2010 |
Modulation of the CRH system by substance P/NKA in an animal model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Carrier Proteins; Cerebral Cortex; Depressive Disorder; Disease Models, Animal; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Olfactory Bulb; Paraventricular Hypothalamic Nucleus; Receptors, Corticotropin-Releasing Hormone; Saccharin; Substance P | 2010 |
Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naloxone; Narcotic Antagonists; Neurokinin A; Pain; Pain Measurement; Respiratory Insufficiency; Substance P; Tachykinins | 2010 |
Normative values of substance P and neurokinin A in neonates.
Topics: Age Factors; Biomarkers; Female; Humans; Infant, Newborn; Neurokinin A; Pain; Pregnancy; Premature Birth; Reference Values; Substance P | 2010 |
Effect of fluticasone on neuropeptides in nasal lavage in persistent allergic rhinitis.
Topics: Adult; Aged; Androstadienes; Anti-Allergic Agents; Antigens, Dermatophagoides; Female; Fluticasone; Histamine; Humans; Male; Middle Aged; Nasal Lavage Fluid; Neurokinin A; Rhinitis, Allergic, Perennial; Serum Albumin; Statistics, Nonparametric; Substance P; Vasoactive Intestinal Peptide; Young Adult | 2010 |
Substance P inhibits pancreatic ductal bicarbonate secretion via neurokinin receptors 2 and 3 in the guinea pig exocrine pancreas.
Topics: Animals; Bicarbonates; Guinea Pigs; In Vitro Techniques; Neurokinin A; Pancreas, Exocrine; Pancreatic Ducts; Peptide Fragments; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Secretin; Substance P | 2011 |
A galenical of traditional Chinese herbal mixture (THC-002) reduces expression of tachykinin peptides within urethras of spontaneously hypertensive rats.
Topics: Aging; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hypertension; Male; Models, Animal; Neurokinin A; Neurokinin B; Rats; Rats, Inbred SHR; RNA, Messenger; Sodium Chloride; Substance P; Urethra | 2012 |
Distribution and pharmacological characterization of primate NK-2 tachykinin receptor in the central nervous system of the rhesus monkey.
Topics: Animals; Central Nervous System; CHO Cells; Cricetinae; Humans; Macaca mulatta; Male; Neurokinin A; Neurokinin B; Protein Binding; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Transfection | 2011 |
Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells.
Topics: Animals; Apoptosis; Cell Degranulation; Collagen; Disease Models, Animal; Heart Failure; In Situ Nick-End Labeling; Male; Mast Cells; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha; Ultrasonography; Ventricular Remodeling | 2011 |
Neuropeptide levels in nasal secretions from patients with and without chronic cough.
Topics: Adult; Calcitonin Gene-Related Peptide; Case-Control Studies; Cough; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nasal Mucosa; Neurokinin A; ROC Curve; Substance P | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
An antinociceptive role for substance P in acid-induced chronic muscle pain.
Topics: Acid Sensing Ion Channels; Action Potentials; Analgesics; Animals; Chronic Pain; Electrophysiology; Ganglia, Spinal; Gene Deletion; Mice; Mice, Inbred C57BL; Musculoskeletal Pain; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Patch-Clamp Techniques; Protein Precursors; Receptors, Neurokinin-1; Sodium Channels; Substance P; Tachykinins | 2012 |
Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety.
Topics: Animals; Anxiety; Avoidance Learning; Electric Stimulation; Escape Reaction; Fear; Inferior Colliculi; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Periaqueductal Gray; Rats; Rats, Wistar; Substance P; Vocalization, Animal | 2012 |
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
Topics: Animals; Behavior, Animal; Benzamides; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptor Cross-Talk; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Substance P | 2012 |
Quantitative mass spectrometry analysis reveals that deletion of the TRPV1 receptor in mice alters substance P and neurokinin A expression in the central nervous system.
Topics: Animals; Gene Deletion; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Substance P; Tandem Mass Spectrometry; TRPV Cation Channels | 2012 |
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.
Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan | 2013 |
Recurrent major depressive disorder: Imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes.
Topics: Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Monocytes; Neurokinin A; Neurotransmitter Agents; NF-kappa B; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tumor Necrosis Factor-alpha | 2013 |
Neurogenic airway inflammation induced by repeated intra-esophageal instillation of HCl in guinea pigs.
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Esophagus; Guinea Pigs; Hydrochloric Acid; Lung; Neurogenic Inflammation; Neurokinin A; Neurokinin B; Neuropeptides; Nodose Ganglion; Pneumonia; Respiratory System; Substance P; Trachea | 2013 |
Concurrent modulation of extracellular levels of noradrenaline and cAMP during stress and by anxiogenic- or anxiolytic-like neuropeptides in the prefrontal cortex of awake rats.
Topics: Animals; Behavior, Animal; Cholecystokinin; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Galanin; Male; Microdialysis; Neurokinin A; Neuropeptides; Norepinephrine; Peptide Fragments; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Stress, Physiological; Substance P | 2013 |
Effects of Qufeng Xuanfei decoction in animal model of post-infectious cough.
Topics: Animals; Bronchoalveolar Lavage; Calcitonin Gene-Related Peptide; Cell Count; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Infections; Lung; Male; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Substance P | 2014 |
Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats.
Topics: Animals; Estradiol; Female; Goats; Gonadotropin-Releasing Hormone; Infusions, Intravenous; Kisspeptins; Ligands; Luteinizing Hormone; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Signal Transduction; Substance P; Time Factors | 2015 |
The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
Topics: Animals; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hypothalamus; Kisspeptins; Luteinizing Hormone; Male; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Tachykinin; Reproduction; Substance P | 2015 |
Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn.
Topics: Animals; Axons; Female; Gastrin-Releasing Peptide; Gene Expression Profiling; Gene Expression Regulation; Green Fluorescent Proteins; Interneurons; Male; Mice; Mice, Inbred C57BL; Neurokinin A; Neurons, Afferent; Promoter Regions, Genetic; Somatostatin; Spinal Cord Dorsal Horn; Substance P | 2014 |
In vitro pharmacological evaluation of the radiolabeled C-terminal substance P analogue Lys-Phe-Phe-Gly-Leu-Met-NH2: Does a specific binding site exist?
Topics: Amino Acid Sequence; Animals; Binding Sites; Female; Male; Neurokinin A; Peptides; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tachykinins | 2014 |
[Gastroesophageal reflux disease in patients receiving chemotherapy: clinical, endoscopic, morphological and immunohistochemical features].
Topics: Drug Therapy, Combination; Duodenogastric Reflux; Endoscopy, Gastrointestinal; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Neurokinin A; NF-kappa B; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Substance P | 2015 |
Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells.
Topics: Alveolitis, Extrinsic Allergic; Antigen Presentation; Antigens, Surface; Asthma; Cell Differentiation; Cytokines; Dendritic Cells; Humans; Neurokinin A; Neurokinin-1 Receptor Antagonists; Poly I-C; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2015 |
[Effects of Suspending Moxibustion at "Dazhui" (GV 14) on Neurogenic Inflammation in Asthma Rats].
Topics: Acupuncture Points; Animals; Asthma; Bronchoalveolar Lavage Fluid; Humans; Male; Moxibustion; Nerve Growth Factor; Neurogenic Inflammation; Neurokinin A; Rats; Rats, Sprague-Dawley; Substance P | 2015 |
An Analysis of Neuropeptides at Nasal Contact Points of Patients With Secondary Headache.
Topics: Adolescent; Adult; Calcitonin Gene-Related Peptide; Diagnosis, Differential; Endoscopy; Female; Headache Disorders, Secondary; Humans; Male; Middle Aged; Nasal Mucosa; Nasal Obstruction; Nasal Septum; Neurokinin A; Prospective Studies; Substance P; Turbinates; Young Adult | 2016 |
Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.
Topics: Adult; Biomarkers, Tumor; Blotting, Western; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Leiomyoma; Middle Aged; Neurokinin A; Real-Time Polymerase Chain Reaction; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Uterine Neoplasms | 2016 |
Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor.
Topics: Algorithms; Animals; Astrocytoma; Binding, Competitive; Cell Line, Tumor; CHO Cells; Cricetulus; Electric Impedance; Humans; Kinetics; Ligands; Nerve Tissue Proteins; Neuroglia; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Tachykinins | 2016 |
Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes?
Topics: Animals; Dose-Response Relationship, Drug; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Immunohistochemistry; Kisspeptins; Luteinizing Hormone; Neurokinin A; Neurokinin B; Neurons; Receptors, Neurokinin-1; Sheep; Signal Transduction; Substance P | 2016 |
Renal sodium handling and blood pressure changes in gestational protein-restricted offspring: Role of renal nerves and ganglia neurokinin expression.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Catecholamines; Creatinine; Diet, Protein-Restricted; Female; Ganglia, Spinal; Kidney; Kidney Pelvis; Lithium; Male; Microscopy, Fluorescence; Neurokinin A; Potassium; Rats; Rats, Wistar; Sodium; Substance P | 2017 |
From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.
Topics: Aprepitant; Cell Line, Tumor; Humans; Kinetics; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pharmaceutical Preparations; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2017 |
The research of the possible mechanism and the treatment for capsaicin-induced cough.
Topics: Animals; Antitussive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Codeine; Cough; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Guinea Pigs; Male; Neurokinin A; Pyrrolidines; Substance P; TRPV Cation Channels; Urea | 2018 |
Tachykinin upregulation in atopic dermatitis.
Topics: Adult; Biopsy; Cross-Sectional Studies; Dermatitis, Atopic; Female; Humans; Inflammation; Male; Middle Aged; Nerve Fibers; Neurokinin A; Receptors, Neurokinin-1; Skin; Substance P; Surveys and Questionnaires; Up-Regulation; Young Adult | 2019 |
Characterization of the Role of NKA in the Control of Puberty Onset and Gonadotropin Release in the Female Mouse.
Topics: Animals; Female; Gonadotropins; Kisspeptins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Neurokinin B; Protein Precursors; Receptors, Neurokinin-2; Sexual Maturation; Substance P; Tachykinins | 2019 |
Mycoplasma hyopneumoniae surface-associated proteases cleave bradykinin, substance P, neurokinin A and neuropeptide Y.
Topics: Adhesins, Bacterial; Aminopeptidases; Animals; Bacterial Proteins; Bradykinin; Immunity, Innate; Metalloendopeptidases; Mycoplasma hyopneumoniae; Neurokinin A; Neuropeptide Y; Proteomics; Substance P; Swine; Trypsin | 2019 |
Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides.
Topics: Adolescent; Adult; Alternative Splicing; Animals; Benzamides; Biopsy; Bone Marrow; Bone Marrow Transplantation; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; HEK293 Cells; Hematopoiesis; Hematopoietic Stem Cells; HMGB1 Protein; Humans; Mice; Neuroimmunomodulation; Neurokinin A; Oligonucleotide Array Sequence Analysis; Piperidines; Primary Cell Culture; Substance P; Tachykinins; Transplantation Chimera; Young Adult | 2020 |
Effects of inhalation of sevoflurane at different concentrations on TRPV1 in airways of rats at different developmental stages.
Topics: Administration, Inhalation; Age Factors; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Neurokinin A; Neurokinin B; Rats; Rats, Sprague-Dawley; Respiration; Sevoflurane; Substance P; Trachea; TRPV Cation Channels | 2020 |
Comparison of Neurokinin A, Substance P, Interleukin 8, and Matrix Metalloproteinase-8 Changes in Pulp tissue and Gingival Crevicular Fluid Samples of Healthy and Symptomatic Irreversible Pulpitis Teeth.
Topics: Gingival Crevicular Fluid; Humans; Interleukin-8; Matrix Metalloproteinase 8; Neurokinin A; Pulpitis; Substance P | 2020 |
Ionic signalling mechanisms involved in neurokinin-3 receptor-mediated augmentation of fear-potentiated startle response in the basolateral amygdala.
Topics: Animals; Basolateral Nuclear Complex; Fear; Mice; Neurokinin A; Neurokinin B; Phosphatidylinositols; Phospholipases; Protein Kinase C; Rats; Receptors, Neurokinin-3; Reflex, Startle; Substance P; TRPC Cation Channels | 2022 |
Regional differences of tachykinin effects on smooth muscle and pacemaker potentials of the stomach, duodenum, ileum and colon of an emetic model, the house musk shrews.
Topics: Animals; Colon; Duodenum; Emetics; Ileum; Muscle Contraction; Muscle, Smooth; Neurokinin A; Receptors, Neurokinin-2; Shrews; Stomach; Substance P; Tachykinins | 2023 |
The Role of Substance P, Neurokinin A, Neuropeptide Y, and Cortisol in Assessing Neonatal Pain.
Topics: Humans; Hydrocortisone; Infant; Infant, Newborn; Neurokinin A; Neuropeptide Y; Pain; Prospective Studies; Substance P | 2023 |