substance p has been researched along with gr 73632 in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 44 (57.89) | 18.2507 |
| 2000's | 22 (28.95) | 29.6817 |
| 2010's | 10 (13.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elliott, PJ; Graham, EA; Hagan, RM; Mason, GS; Turpin, MP | 1 |
| Clark, D; Elliott, PJ; Hagan, RM; Overton, P | 1 |
| Connor, HE; Feniuk, W; Stubbs, CM; Waldron, GJ | 1 |
| Ball, DI; Coleman, RA; Sheldrick, RL | 1 |
| Hall, JM; Mitchell, D; Morton, IK | 1 |
| Elliott, PJ; Hagan, RM; Mason, GS; Stephens-Smith, M | 1 |
| Beresford, IJ; Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; Ward, P | 1 |
| Hall, JM; Morton, IK | 1 |
| Bristow, LJ; Young, L | 1 |
| Buéno, L; Julia, V; Morteau, O | 1 |
| Rupniak, NM; Williams, AR | 1 |
| Arkinstall, S; Beresford, IJ; Hagan, RM; Ireland, SJ; Seale, PW; Stables, JM; Walsh, DM; Ward, P | 1 |
| Lecci, A; Maggi, CA; Meini, S; Patacchini, R; Poulos, C; Rovero, P | 1 |
| Bentley, GN; Gent, JP | 1 |
| Chizh, BA; Cumberbatch, MJ; Headley, PM | 1 |
| Beattie, DT; Connor, HE; Feniuk, W; Stubbs, CM | 1 |
| Dray, A; Maggi, CA; Nagy, I; Urban, L; Woolf, CJ | 1 |
| Barker, R; Dunnett, S; Fawcett, J | 1 |
| Connor, HE; O'Shaughnessy, CT | 1 |
| Dalforno, G; Gaviraghi, G; Hagan, RM; Palea, S; Pietra, C; Trist, DG | 1 |
| Beattie, DT; Connor, HE; McNeil, DK | 1 |
| Barnes, PJ; Maclagan, J; Watson, N | 1 |
| Honda, K; Kamiya, H; Nakayama, Y; Saigo, A; Saito, R; Takano, Y | 1 |
| Antunes, E; Brain, SD; Costa, SK; de Nucci, G; Palframan, RT; Wilsoncroft, P | 1 |
| Beresford, IJ; Hagan, RM; Hawcock, AB; Marshall, FH | 1 |
| Cammack, C; Logan, SD | 1 |
| Carpenter, E; Gent, JP; Maudsley, S; Peers, C; Phenna, S | 1 |
| Boyce, S; Carlson, E; Hill, RG; Rupniak, NMJ; Webb, JK | 1 |
| Chikama, T; Nakamura, M; Nishida, T; Ofuji, K | 1 |
| Ber, E; Carlson, EJ; Cascieri, MA; Hale, JJ; Hargreaves, RJ; Hill, RG; Huscroft, I; MacCoss, M; Mills, SG; Owen, S; Rupniak, NM; Rycroft, W; Sadowski, S; Seward, E; Swain, CJ; Tattersall, FD; Williams, AR | 1 |
| Burkholder, TP; Kehne, JH; Knippenberg, RW; Kudlacz, EM; McCloskey, TC; Shatzer, SA | 1 |
| Bauer, J; Berger, M; Fiebich, BL; Lieb, K; Schulze-Osthoff, K | 1 |
| Altier, N; Stewart, J | 1 |
| Cody, C; Jones, RS; Maubach, KA | 1 |
| Fowler, WL; Williams, CA | 1 |
| Bost, KL; Marriott, I | 1 |
| De Oca, BM; Fanselow, MS; Marsden, CA; Mongeau, R | 1 |
| Brain, SD; Towler, PK | 1 |
| Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; Minson, JB; Pilowsky, PM; Solomon, SG | 1 |
| Brain, SD; Brown, B; Hoult, JR; Pintér, E | 1 |
| Bargas, J; Galarraga, E; Hernández-López, S; Reyes, A; Tapia, D | 1 |
| Ando, R; Inoue, M; Kisara, K; Sakurada, C; Sakurada, T; Tan-No, K; Watanabe, C | 1 |
| Heinemann, A; Holzer, P | 1 |
| Barthó, L; Corinaldesi, R; De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Sternini, C; Tramontana, M | 1 |
| Carlson, EC; de Felipe, C; Harrison, T; Hunt, S; Oates, B; Owen, S; Rupniak, NM; Seward, E; Wheeldon, A | 1 |
| Holzer, P; Shahbazian, A | 1 |
| Hancock, JC; Hoover, DB; Schoborg, RV; Tompkins, JD | 1 |
| Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT | 1 |
| Bradesi, S; Bueno, L; Eutamene, H; Fioramonti, J | 1 |
| Greenwood-Van Meerveld, B; Sutkowski-Markmann, DM; Venkova, K | 1 |
| Hancock, JC; Tompkins, JD | 1 |
| Boyce, S; Fisher, A; Rupniak, NM; Smith, D; Webb, JK | 1 |
| Greenwood-Van Meerveld, B; Venkova, K | 1 |
| Arreaza, MG; Duffy, RA; Lachowicz, JE; Qiu, P; Randolph, GP; Simon, JS | 1 |
| Bertani, S; Bifone, A; Corsi, M; Crestan, V; Gozzi, A; Reese, T; Schwarz, AJ; Turrini, G | 1 |
| Iwema Bakker, WI; McCreary, AC; Mulder, AT; van den Hoogenband, A; van Maarseveen, JH; van Scharrenburg, GJ; van Stuivenberg, HH; Zethof, TJ; Zijta, B | 1 |
| Huizinga, JD; Nieuwmeyer, F; Ye, J | 1 |
| Ballard, TM; Haman, M; Higgins, GA; Woolley, ML | 1 |
| Hauer-Jensen, M; Kulkarni, A; Qiu, X; Wang, J | 1 |
| Adolfsson, R; Ahlstedt, I; de Verdier, J; Drmota, T; Engberg, S; Johansson, A; Jussila, R; Kristensson, E; Leffler, A; Lindström, E; Novén, A; Påhlman, I; Sigfridsson, K; Sundqvist, M; von Mentzer, B | 1 |
| Arihiro, K; Li, YS; Nakata, Y; Tang, HB | 1 |
| Asai, H; Ishii, T; Kiuchi, S; Nagasaki, M; Okamoto, M; Saito, A; Taniguchi, H; Watanabe, Y | 1 |
| Abad, J; Darmani, NA; Ramirez, J; Ray, AP; Thrush, GR; Wang, Y | 1 |
| Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T | 1 |
| Li, YS; Miyano, K; Nakata, Y; Tang, HB | 1 |
| Chebolu, S; Darmani, NA; Ramirez, J; Ray, AP | 1 |
| Gehlert, DR; Iyengar, S; Kielbasa, W; Marek, G; Mozley, D; Peng, X; Tauscher, J; Vandenhende, F | 1 |
| Belkadi, A; Diaconu, D; Loyd, CM; Ostrowski, SM; Ward, NL | 1 |
| Alkam, T; Amos, B; Chebolu, S; Darmani, NA | 1 |
| Imazumi, K; Kikuchi, A; Maeda, Y; Manda, T; Matsuo, M; Sakuma, H; Sogabe, H; Uchida, W; Yamakuni, H; Yoshino-Furukawa, T | 1 |
| Ball, RG; Bao, J; Bunda, J; Chicchi, G; Cook, J; DeVita, RJ; Doss, GA; Eng, W; Gantert, L; Hargreaves, R; Hora, DF; Jiang, J; Karanam, B; Kassick, AJ; Kumar, S; Lin, P; Lu, H; Madeira, M; Mills, SG; Purcell, M; Samuel, K; Tong, X; Tsao, KL; Tschirret-Guth, R; Wang, H; Wilson, D | 1 |
| Arapulisamy, O; Jayanthi, LD; Mannangatti, P | 1 |
| Fisher, A; Ratti, E; Trower, MK; Upton, N | 1 |
| Navarro, VM; Ohkura, S; Okamura, H; Wakabayashi, Y; Yamamura, T | 1 |
| Bettelini, L; Corsi, M; Costantini, VJ; Dünstl, G; Gerrard, P; Zonzini, L | 1 |
| Carroll, RS; Gill, JC; Kaiser, UB; Maguire, CA; Navarro, VM; Simavli, S; Thompson, IR; Wolfe, A | 1 |
1 trial(s) available for substance p and gr 73632
| Article | Year |
|---|---|
Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder.
Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Dose-Response Relationship, Drug; Gerbillinae; Humans; Male; Neurokinin-1 Receptor Antagonists; Paroxetine; Peptide Fragments; Pyridines; Radioligand Assay; Radionuclide Imaging; Receptors, Neurokinin-1; Stereotyped Behavior; Substance P; Treatment Outcome; Triazoles | 2010 |
75 other study(ies) available for substance p and gr 73632
| Article | Year |
|---|---|
Modulation of the rat mesolimbic dopamine pathway by neurokinins.
Topics: Animals; Behavior, Animal; Dopamine; Injections, Intraventricular; Limbic System; Male; Neural Pathways; Nucleus Accumbens; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P; Tachykinins | 1992 |
Neurokinin agonists differentially affect A9 and A10 dopamine cells in the rat.
Topics: Animals; Dopamine; Neurokinin A; Neurons; Peptide Fragments; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1992 |
Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation.
Topics: Animals; Arginine; Capsaicin; Cerebral Arteries; Dogs; Electric Stimulation; Endothelium, Vascular; In Vitro Techniques; omega-N-Methylarginine; Peptide Fragments; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synaptic Transmission; Vasodilation | 1992 |
Characterisation of the neurokinin receptors mediating contraction of isolated tracheal preparations from a variety of species.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P; Swine; Trachea | 1990 |
Neurokinin receptors in the rabbit iris sphincter characterised by novel agonist ligands.
Topics: Animals; In Vitro Techniques; Iris; Kinetics; Ligands; Male; Neurokinin A; Peptide Fragments; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Behavioural and biochemical responses following activation of midbrain dopamine pathways by receptor selective neurokinin agonists.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Dopamine; Haloperidol; Limbic System; Male; Mesencephalon; Molecular Sequence Data; Motor Activity; Neural Pathways; Neurokinin A; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1991 |
Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.
Topics: Administration, Cutaneous; Amino Acid Sequence; Animals; Bronchoconstriction; Capillary Permeability; Chromatography, High Pressure Liquid; Guinea Pigs; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Trachea | 1991 |
Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation.
Topics: Animals; Electric Stimulation; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Transmission; Vas Deferens | 1991 |
Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gerbillinae; Harderian Gland; Indoles; Injections, Intravenous; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P | 1994 |
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins | 1994 |
Differential inhibition of foot tapping and chromodacryorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK1 receptor antagonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biological Assay; Blood-Brain Barrier; Female; Gerbillinae; Injections, Intravenous; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Substance P; Tears | 1994 |
GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Astrocytoma; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Humans; Male; Molecular Sequence Data; Neurokinin B; Oligopeptides; Peptide Fragments; Portal Vein; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transfection; Tumor Cells, Cultured | 1994 |
GR 73,632 and [Glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder.
Topics: Animals; Dose-Response Relationship, Drug; Glutamic Acid; Guinea Pigs; Male; Peptide Fragments; Physalaemin; Rabbits; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Neurokinin actions on substantia gelatinosa neurones in an adult longitudinal spinal cord preparation.
Topics: Afferent Pathways; Animals; Electric Stimulation; Male; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Substance P; Substantia Gelatinosa; Time Factors | 1995 |
Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acids; Male; N-Methylaspartate; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1995 |
Neurokinin-induced changes in pial artery diameter in the anaesthetized guinea-pig.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Physalaemin; Pia Mater; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Vasodilation | 1993 |
The role of neurokinin and N-methyl-D-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Biphenyl Compounds; Capsaicin; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P; Synapses; Synaptic Transmission | 1993 |
A selective tachykinin receptor agonist promotes differentiation but not survival of rat chromaffin cells in vitro.
Topics: Adrenal Glands; Animals; Cell Differentiation; Cell Survival; Chromaffin System; Fluorescent Antibody Technique; Hexamethonium Compounds; Immunohistochemistry; In Vitro Techniques; Nerve Growth Factors; Neurites; Neurokinin A; Peptide Fragments; Phenotype; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tyrosine 3-Monooxygenase | 1993 |
Neurokinin NK1 receptors mediate plasma protein extravasation in guinea-pig dura.
Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Conjunctiva; Dura Mater; Guinea Pigs; Male; Peptide Fragments; Physalaemin; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intra-Arterial; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Reflex; Substance P; Urinary Bladder; Urination | 1993 |
The influence of neurokinins and calcitonin gene-related peptide on cerebral blood flow in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Cerebrovascular Circulation; Guinea Pigs; Kinetics; Male; Neurokinin A; Peptide Fragments; Substance P | 1993 |
Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea.
Topics: Acetylcholine; Animals; Capsaicin; Electric Stimulation; Ganglia, Parasympathetic; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neuropeptides; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Trachea; Vagus Nerve | 1993 |
Role of NK-1 receptor in central cardiovascular regulation in rats: studies on a novel non-peptide antagonist, CP-96,345, of substance P NK-1 receptor.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Heart Rate; Hypnotics and Sedatives; Injections, Intraventricular; Male; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, Neurokinin-1; Substance P; Tachykinins; Vas Deferens | 1993 |
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrilamine; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin Diseases; Spider Venoms; Substance P | 1996 |
Temperature and agonist dependency of tachykinin NK1 receptor antagonist potencies in rat isolated superior cervical ganglion.
Topics: Animals; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Receptors, Neurokinin-1; Substance P; Superior Cervical Ganglion; Temperature; Tetrodotoxin | 1995 |
Excitation of rat sympathetic preganglionic neurones by selective activation of the NK1 receptor.
Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Patch-Clamp Techniques; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Strychnine; Substance P; Sympathetic Nervous System | 1996 |
Inhibition of Ca(2+)-sensitive K+ currents in NG 108-15 cells by substance P and related tachykinins.
Topics: Animals; Calcium; Calcium Channels; Drug Interactions; Glioma; Kinetics; Mice; Neuroblastoma; Peptide Fragments; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Receptors, Neurokinin-1; Sensitivity and Specificity; Substance P; Tachykinins; Tumor Cells, Cultured | 1996 |
Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils.
Topics: Animals; Female; Foot; Formaldehyde; Gerbillinae; Injections; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Nociceptors; Peptide Fragments; Piperidines; Stereoisomerism; Substance P; Time Factors | 1996 |
The NK1 receptor and its participation in the synergistic enhancement of corneal epithelial migration by substance P and insulin-like growth factor-1.
Topics: Animals; Cell Movement; Cornea; Drug Synergism; Epithelium; Insulin-Like Growth Factor I; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Substance P | 1997 |
In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists.
Topics: Administration, Oral; Animals; Antiemetics; Brain; CHO Cells; Cisplatin; Cloning, Molecular; Cricetinae; Ferrets; Gerbillinae; Humans; Infusions, Intravenous; Membranes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Radioligand Assay; Substance P | 1997 |
The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.
Topics: Animals; Behavior, Animal; Capillary Permeability; Gerbillinae; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Male; Morpholines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Plethysmography, Whole Body; Radioligand Assay; Receptors, Neurokinin-2; Respiratory Mechanics; Substance P; Tachykinins | 1997 |
The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells.
Topics: Astrocytoma; Calcium; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Intracellular Fluid; Neurokinin-1 Receptor Antagonists; NF-kappa B; Peptide Fragments; RNA, Messenger; Substance P; Time Factors; Tumor Cells, Cultured | 1997 |
Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions.
Topics: Amphetamine; Analgesics, Non-Narcotic; Animals; Central Nervous System Stimulants; Formaldehyde; Male; Microinjections; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 1997 |
Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition.
Topics: Animals; Baclofen; Bicuculline; Entorhinal Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Phosphinic Acids; Propanolamines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Receptors, GABA-B; Substance P; Synapses; Tachykinins | 1998 |
Substance P released in the rostral brainstem of cats interacts with NK-1 receptors during muscle pressor response.
Topics: Animals; Brain Stem; Cardiovascular System; Cats; Isometric Contraction; Muscle Fatigue; Muscle, Skeletal; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Receptors, Neurokinin-1; Reflex; Substance P | 1997 |
Substance P diminishes lipopolysaccharide and interferon-gamma-induced TGF-beta 1 production by cultured murine macrophages.
Topics: Animals; Cells, Cultured; Drug Interactions; Inflammation; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Peptide Fragments; RNA, Messenger; Substance P; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation | 1998 |
Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Classical; Electroshock; Escape Reaction; Fear; Homocysteine; Inhibition, Psychological; Male; Pain Measurement; Peptide Fragments; Periaqueductal Gray; Rats; Rats, Long-Evans; Receptors, Neurokinin-1; Substance P | 1998 |
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Edema; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Time Factors | 1998 |
Neurokinin-1 receptors and spinal cord control of blood pressure in spontaneously hypertensive rats.
Topics: Analgesics; Animals; Blood Pressure; Heart Rate; Hypertension; Indoles; Injections, Spinal; Isoindoles; Neurons; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neurokinin-1; Spinal Cord; Substance P; Sympathetic Nervous System | 1999 |
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors | 1999 |
Action of substance P (neurokinin-1) receptor activation on rat neostriatal projection neurons.
Topics: Animals; Corpus Striatum; Electrophysiology; In Vitro Techniques; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Synaptic Transmission | 1999 |
Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Drug Interactions; Injections, Spinal; Male; Mice; Peptide Fragments; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1999 |
Intestinal motor depression by 7-nitroindazole through an action unrelated to nitric oxide synthase inhibition.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guinea Pigs; Imidazoles; In Vitro Techniques; Indazoles; Indomethacin; Intestine, Small; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Sincalide; Substance P; Tetrodotoxin | 1999 |
Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea-pig small intestine.
Topics: Adrenergic Agents; Animals; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Immunohistochemistry; Intestine, Small; Male; Myenteric Plexus; NADPH Dehydrogenase; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tetrodotoxin | 1999 |
Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Buspirone; Diazepam; Dose-Response Relationship, Drug; Female; Fluoxetine; Gene Deletion; Guinea Pigs; Imipramine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Social Isolation; Stress, Psychological; Substance P; Tetrazoles; Vocalization, Animal | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Increased ganglionic responses to substance P in hypertensive rats due to upregulation of NK(1) receptors.
Topics: Animals; Autoradiography; Ganglia, Sympathetic; Heart Rate; Hypertension; Kidney; Male; Peptide Fragments; Physalaemin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P | 2000 |
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine | 2001 |
Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids.
Topics: Animals; Colon; Female; Gonadal Steroid Hormones; Histamine Release; Hormone Antagonists; Mifepristone; Neurokinin-1 Receptor Antagonists; Ovary; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Restraint, Physical; Stress, Psychological; Substance P | 2002 |
Peripheral activity of a new NK1 receptor antagonist TAK-637 in the gastrointestinal tract.
Topics: Animals; Capsaicin; Digestive System; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Naphthyridines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Substance P | 2002 |
Electrophysiological effects of tachykinin agonists on sympathetic ganglia of spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Heart Rate; Hypertension; Male; Membrane Potentials; Neurons; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neurokinin-1; Receptors, Tachykinin; Substance P; Tachykinins | 2002 |
The substance P (NK1) receptor antagonist L-760735 inhibits fear conditioning in gerbils.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Conditioning, Psychological; Fear; Female; Gerbillinae; Ibotenic Acid; Male; Morpholines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Substance P | 2003 |
Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion.
Topics: Animals; Capsaicin; Colforsin; Colon; Electric Stimulation; Electrophysiology; Guinea Pigs; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Naphthyridines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Statistics, Nonparametric; Substance P; Tetrodotoxin | 2004 |
Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant.
Topics: Alleles; Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Gene Frequency; Genetic Variation; Histidine; Humans; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Polymorphism, Single Nucleotide; Protein Binding; Receptors, Neurokinin-1; Substance P; Tyrosine | 2004 |
Functional magnetic resonance mapping of intracerebroventricular infusion of a neuroactive peptide in the anaesthetised rat.
Topics: Anesthetics; Animals; Brain; Brain Mapping; Cerebrovascular Circulation; Drug Delivery Systems; Injections, Intraventricular; Lateral Ventricles; Magnetic Resonance Imaging; Male; Neuropeptides; Neuropharmacology; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
Piperazinyl oxime ethers as NK-1 receptor antagonists.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Ethers; Gerbillinae; Humans; Molecular Conformation; Motor Activity; Neurokinin-1 Receptor Antagonists; Oximes; Peptide Fragments; Piperazines; Structure-Activity Relationship; Substance P | 2006 |
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.
Topics: Action Potentials; Animals; Coiled Bodies; Dilatation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Mice; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Investigating the effect of bilateral amygdala lesions on fear conditioning and social interaction in the male Mongolian gerbil.
Topics: Amygdala; Analysis of Variance; Animals; Aprepitant; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Interactions; Fear; Gerbillinae; Ibotenic Acid; Immobility Response, Tonic; Interpersonal Relations; Male; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Substance P | 2006 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Foot; Gerbillinae; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2007 |
Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons.
Topics: Analysis of Variance; Animals; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Ganglia, Spinal; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-1; Subcellular Fractions; Substance P | 2007 |
Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor.
Topics: Animals; Antiemetics; Antineoplastic Agents; Aprepitant; Binding Sites; Brain; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Ferrets; Gerbillinae; Humans; Kinetics; Male; Morpholines; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Substance P; Transfection; Vomiting | 2008 |
Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.
Topics: Animals; Antiemetics; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enteric Nervous System; Neurokinin-1 Receptor Antagonists; Oncogene Proteins v-fos; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Shrews; Stereotyped Behavior; Substance P; Time Factors; Tissue Distribution; Vomiting | 2008 |
Neurokinin receptor modulation of respiratory activity in the rabbit.
Topics: Animals; Exhalation; Inhalation; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phrenic Nerve; Piperidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Vagotomy | 2008 |
Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Capsaicin; Cells, Cultured; Enzyme Inhibitors; Ganglia, Spinal; Neurons; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Time Factors; TRPV Cation Channels | 2008 |
Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Stem; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intraventricular; Intestine, Small; Myenteric Plexus; Peptide Fragments; Photomicrography; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Shrews; Substance P; Vomiting | 2009 |
Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner.
Topics: Animals; CD11c Antigen; CD4 Lymphocyte Count; Denervation; Disease Models, Animal; Ganglia, Spinal; Interleukin-23; Isoindoles; Keratinocytes; Mice; Neuropeptides; Peptide Fragments; Psoriasis; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Receptors, Calcitonin Gene-Related Peptide; Skin; Substance P | 2011 |
Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva).
Topics: Analysis of Variance; Animals; Antiemetics; Dose-Response Relationship, Drug; Drug Synergism; Female; Indoles; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Shrews; Substance P; Tropisetron; Vomiting | 2011 |
Pharmacological properties of FK886, a new, centrally active neurokinin-1 receptor antagonist.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Gerbillinae; Humans; Male; Morpholines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Tissue Distribution | 2013 |
2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Glucuronides; Humans; Isoindoles; Metabolic Clearance Rate; Neurokinin-1 Receptor Antagonists; Oxazoles; Peptide Fragments; Substance P | 2013 |
Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization.
Topics: Animals; Down-Regulation; Endocytosis; Humans; Male; Membrane Microdomains; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Peptide Fragments; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Subcellular Fractions; Substance P | 2013 |
Neurokinin-1 receptor antagonist orvepitant is an effective inhibitor of itch-associated response in a Mongolian gerbil model of scratching behaviour.
Topics: Administration, Oral; Animals; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pruritus; Substance P | 2014 |
Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats.
Topics: Animals; Estradiol; Female; Goats; Gonadotropin-Releasing Hormone; Infusions, Intravenous; Kisspeptins; Ligands; Luteinizing Hormone; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Signal Transduction; Substance P; Time Factors | 2015 |
The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration.
Topics: Administration, Oral; Administration, Topical; Animals; Antipruritics; Aprepitant; Disease Models, Animal; Drug Evaluation, Preclinical; Gerbillinae; Humans; Injections, Intradermal; Morpholines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pruritus; Receptors, Neurokinin-1; Substance P | 2015 |
Substance p regulates puberty onset and fertility in the female mouse.
Topics: Animals; Female; Fertility; Gonadotropins; Mice; Peptide Fragments; Puberty; Receptors, Neurokinin-1; Sexual Maturation; Substance P | 2015 |