substance p has been researched along with formaldehyde in 99 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (13.13) | 18.7374 |
1990's | 41 (41.41) | 18.2507 |
2000's | 26 (26.26) | 29.6817 |
2010's | 19 (19.19) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Grimelius, L; Lundqvist, G; Portela-Gomes, G; Skoog, V; Westermark, P; Wilander, E | 1 |
Berge, OG; Hole, K; Lund, A; Mjellem-Joly, N | 1 |
Chayvialle, JA; Chéry-Croze, S; Miampamba, M | 1 |
Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 2 |
Goldstein, BD; McCarson, KE | 3 |
Goldstein, BD; Holland, LN | 2 |
Cowan, A; Larson, AA; Murray, CW | 1 |
Ono, M; Satoh, T | 1 |
Anderson, K; Bernstein, D; Cominelli, F; Davis, W; Eysselein, VE; Khan, H; Nast, CC; Patel, A; Reinshagen, M; Sternini, C | 1 |
Ferrell, WR; Lam, FY | 1 |
Goldstein, BD; Kantner, RM; Kirby, ML | 2 |
Wakisaka, S | 1 |
Fasmer, OB; Hole, K; Post, C | 1 |
Besson, JM; Calvino, B; Couraud, JY; Maillet, S; Pradelles, P | 1 |
Hanashima, N; Hirota, N; Kuraishi, Y; Sato, Y; Satoh, M; Takagi, H | 1 |
Fujita, T; Iwanaga, T; Teraki, Y; Yoshie, S | 1 |
Fasmer, OB; Hole, K; Hunskaar, S | 1 |
Somogyi, P; Takagi, H | 1 |
Mishima, H; Sears, M; Stjernschantz, J | 1 |
McDonald, DM | 1 |
Bravo, R; Herdegen, T; Mayer, B; Rüdiger, S; Zimmermann, M | 1 |
Mi, ZP; Qiao, JT; Zhang, RX | 1 |
Coderre, TJ; Yashpal, K | 1 |
Krause, JE; McCarson, KE | 1 |
Hayashi, K; Kuraishi, Y; Nagasawa, T; Satoh, M | 1 |
Katsumata, K; Kisara, K; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
Coderre, TJ; Henry, JL; Radhakrishnan, V; Yashpal, K | 1 |
Mi, ZP; Qiao, JT; Xie, YF; Zhang, RX | 1 |
Hitosugi, H; Kamei, J; Kasuya, Y | 2 |
Katsumata, K; Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
Carruette, A; Garret, C; Moussaoui, S | 1 |
Katsumata, K; Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
Ohkubo, T; Shibata, M; Takahashi, H | 1 |
Canella, R; Leon, A; Marcolongo, G; Mazzari, S; Petrelli, L | 1 |
Traub, RJ | 1 |
Boyce, S; Carlson, E; Hill, RG; Rupniak, NMJ; Webb, JK | 1 |
Goettl, VM; Larson, AA | 1 |
Boucher, S; Couture, R; Gehlert, DR; Helton, DR; Hipskind, PA; Iyengar, S; Kallman, MJ; Li, DL; Lobb, KL; Nixon, JA; Schober, D; Simmons, RM | 1 |
Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL | 1 |
Altier, N; Stewart, J | 1 |
Baffi, J; König, M; Mezey, E; Palkovits, M; Reynolds, K; Usdin, T; Zimmer, A; Zimmer, AM | 1 |
Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ | 1 |
Choi, HS; Kim, SK; Nah, JJ; Nah, SY; Nam, KY; Shin, YH; Yoon, SR | 1 |
Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA | 1 |
Betsholtz, C; Gebre-Medhin, S; Mulder, H; Sundler, F; Zhang, Y | 1 |
Chabot, J; Coderre, TJ; Henry, JL; Pitcher, GM; Yashpal, K | 1 |
McCarson, KE | 1 |
Calcutt, NA; Gustafsson, H; Malmberg, AB; Stiller, C | 1 |
Choi, SS; Chung, KM; Lee, KC; Suh, HW | 1 |
Hashimoto, T; Iijima, Y; Ishigooka, M; Nakada, T; Yaguchi, H | 1 |
Forrest, L; Hughes, C; Puskar, Z; Spike, RC; Todd, AJ; Watt, C | 1 |
Salam, OM | 1 |
Calixto, JB; Cechinel-Filho, V; Ferreira, J; Malheiros, A; Santos, AR; Scheidt, C; Yunes, RA | 1 |
Dun, NJ; Hua, F; Ricketts, BA; Williams, CA | 1 |
Adler, G; Eysselein, VE; Reinshagen, M | 1 |
Inoue, M; Kawashima, T; Kishioka, S; Maeda, T; Matsumoto, M; Rashid, MH; Ueda, H | 1 |
Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
Anderson, LJ; Barskey, A; Haynes, LM; Jones, LP; Tripp, RA | 1 |
Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL | 1 |
Choi, SS; Han, EJ; Han, KJ; Lee, HK; Suh, HW | 1 |
Czaja, K; Kaleczyc, J; Lakomy, M; Pidsudko, Z; Sienkiewicz, W; Wasowicz, K | 1 |
Del Turco, D; Deller, T; Feil, R; Geisslinger, G; Hofmann, F; Ruth, P; Sausbier, M; Schmidtko, A; Tegeder, I | 1 |
de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM | 1 |
Bianchi, M; Biella, G; Ferrario, P; Martucci, C; Sacerdote, P | 1 |
Liu, Y; Yang, MH; Zhang, HY | 1 |
Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A | 1 |
Fu, NA; Liu, JY; Wang, QX; Wang, XY; Yao, SL | 1 |
Akada, Y; Amano, K; Fukudome, Y; Itoh, M; Ogawa, S; Yamamoto, I; Yamasaki, F | 1 |
DeHate, RB; Richards, IS | 1 |
Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C | 1 |
Choi, HW; Jang, JE; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW | 1 |
Choi, HW; Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Nam, JS; Park, SH; Seo, YJ; Suh, HW | 1 |
Christianson, CA; Hua, XY; Nazarian, A; Yaksh, TL | 1 |
Dong, H; Geng, X; Lu, X; Yu, H; Zeng, Y; Zhang, L | 1 |
Ito, K; Miyake, M; Muto, T; Ohshima, M; Sakamoto, T; Takeda, M; Ueda, N | 1 |
Csillik, B; Knyihár-Csillik, E; Mihály, A | 1 |
Ballard, CJ; Hurley, JH; Kunkler, PE; Oxford, GS | 1 |
Fitzsimmons, B; Hua, XY; Newton, AC; O'Neill, A; Steinauer, J; Xu, Q; Yaksh, TL | 1 |
Beaudry, H; Dubois, D; Gendron, L | 1 |
Ikeda, T; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 1 |
Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 1 |
Jin, Y; Li, C; Liu, W; Wang, F | 1 |
Chen, PX; Guo, HM; Huang, JH; Luo, YL; Zhang, YL; Zhou, WL; Zhu, YX | 1 |
Hisaoka-Nakashima, K; Izumi, H; Morioka, N; Nakamura, Y; Nakata, Y; Shimizu, T | 1 |
Chen, T; Ji, W; Li, H; Li, YQ; Pei, LY; Wang, W; Wu, SX; Zhang, MM; Zhang, T | 1 |
Chen, R; Lai, K; Li, J; Li, L; Liu, X; Ma, P; Wu, Y; Yang, X; Yao, H; Ye, X; You, H; Yuan, Y | 1 |
Kang, YJ; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW | 1 |
Almasarweh, F; Are, D; Armendariz, A; Nazarian, A; Tenayuca, JM | 1 |
Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
Ebihara, K; Funahashi, H; Ikeda, T; Ishida, Y; Koganemaru, G; Kuramashi, A; Naono-Nakayama, R; Nishimori, T | 1 |
Dong, YL; Li, YQ; Lu, YC; Wang, J; Wang, W; Wei, YY; Wu, HH; Wu, SX; Yin, JB; Zhang, T; Zhang, Y | 1 |
Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW | 1 |
99 other study(ies) available for substance p and formaldehyde
Article | Year |
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Substance P and enteroglucagon-like immunoreactivity in argentaffin and argyrophil midgut carcinoid tumours.
Topics: Aged; Carcinoid Tumor; Female; Fluorescent Antibody Technique; Formaldehyde; Gastrointestinal Hormones; Glucagon-Like Peptides; Humans; Immunoenzyme Techniques; Intestinal Neoplasms; Male; Middle Aged; Serotonin; Substance P | 1979 |
Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test.
Topics: Animals; Formaldehyde; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Substance P | 1992 |
Spinal and intestinal levels of substance P, calcitonin gene-related peptide and vasoactive intestinal polypeptide following perendoscopic injection of formalin in rat colonic wall.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Colon, Sigmoid; Colonoscopy; Female; Formaldehyde; Neuropeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Vasoactive Intestinal Peptide | 1992 |
Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.
Topics: Animals; Capsaicin; Cysteamine; Drug Interactions; Formaldehyde; Mice; Pain; Pain Measurement; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1990 |
Time course of the alteration in dorsal horn substance P levels following formalin: blockade by naloxone.
Topics: Animals; Female; Foot; Formaldehyde; Injections; Naloxone; Rats; Rats, Inbred Strains; Sodium Chloride; Spinal Cord; Substance P; Time Factors | 1990 |
Changes of substance P-like immunoreactivity in the dorsal horn are associated with the 'phasic' behavioral response to a formalin stimulus.
Topics: Animals; Behavior, Animal; Epinephrine; Formaldehyde; Immunochemistry; Lidocaine; Male; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord; Stereotyped Behavior; Stimulation, Chemical; Substance P | 1990 |
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Nociceptors; Pain; Peptide Fragments; Reaction Time; Substance P; Urethane | 1991 |
Pharmacological studies on lappaconitine: antinociception and inhibition of the spinal action of substance P and somatostatin.
Topics: Aconitine; Analgesics; Animals; Behavior, Animal; Brain; Cysteamine; Diclofenac; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Neurons; Nociceptors; Somatostatin; Spinal Cord; Substance P | 1991 |
Calcitonin gene-related peptide and substance P decrease in the rabbit colon during colitis. A time study.
Topics: Animals; Antigen-Antibody Complex; Calcitonin Gene-Related Peptide; Colitis; Colon; Formaldehyde; Immunohistochemistry; Intestinal Mucosa; Male; Nerve Fibers; Neurons; Rabbits; Substance P; Time Factors | 1991 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joints; Male; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Substance P; Uric Acid | 1991 |
Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat.
Topics: Animals; Formaldehyde; Hindlimb; Kinetics; Pain; Rats; Spinal Cord; Substance P; Time Factors | 1991 |
Increase in substance P in the dorsal horn during a chemogenic nociceptive stimulus.
Topics: Animals; Electrophysiology; Female; Formaldehyde; Ganglia, Spinal; Immunoenzyme Techniques; Nociceptors; Photometry; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Time Factors | 1985 |
[Immunohistochemical study on substance P in rat molar pulp and periodontal tissues. 1. Effect of decalcifying agents on substance P-like immunoreactivity].
Topics: Animals; Decalcification Technique; Edetic Acid; Formaldehyde; Formates; Male; Mice; Mice, Inbred Strains; Picrates; Polymers; Spinal Cord; Spine; Substance P | 1986 |
Regulatory mechanisms for substance P in the dorsal horn during a nociceptive stimulus: axoplasmic transport vs electrical activity.
Topics: Animals; Axonal Transport; Colchicine; Electrophysiology; Female; Formaldehyde; Nociceptors; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tetrodotoxin | 1986 |
Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and the substance P behavioural assay.
Topics: Animals; Behavior, Animal; Formaldehyde; Male; Mice; Pain; Substance P; Zimeldine | 1987 |
Increased reactivity to chemical but not to heat noxious stimuli in mice producing anti-idiotypic antibodies for substance P.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Formaldehyde; Hot Temperature; Immunoglobulin Idiotypes; Male; Mice; Mice, Inbred BALB C; Pain; Substance P | 1988 |
Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ.
Topics: Animals; Formaldehyde; Hot Temperature; Male; Pain; Physical Stimulation; Rabbits; Spinal Cord; Substance P | 1989 |
Naloxone blocks the formalin-induced increase of substance P in the dorsal horn.
Topics: Animals; Female; Formaldehyde; Immunoenzyme Techniques; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Indomethacin; Male; Mice; Morphine; Nerve Fibers; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Sciatic Nerve; Substance P; Time Factors | 1989 |
Immunocytochemistry of neuron-specific proteins and neuropeptides in taste buds and associated nerves.
Topics: Animals; Calbindin 1; Calbindins; Calcium-Binding Proteins; Cats; Female; Formaldehyde; Guinea Pigs; Immunohistochemistry; Intermediate Filament Proteins; Male; Mice; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Phosphopyruvate Hydratase; Rats; S100 Calcium Binding Protein G; Substance P; Taste Buds | 1989 |
Antinociceptive effects of serotonergic reuptake inhibitors in mice.
Topics: Alanine; Analgesics; Animals; Citalopram; Clomipramine; Desipramine; Formaldehyde; Hot Temperature; Male; Mice; Neurotransmitter Uptake Inhibitors; Serotonin Antagonists; Substance P | 1989 |
A note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry.
Topics: Animals; Axons; Brain; Enkephalin, Leucine; Fixatives; Formaldehyde; Glutaral; Histological Techniques; Immunoenzyme Techniques; Male; Microscopy, Electron; Muridae; Neurons; Neurotransmitter Agents; Picrates; Polymers; Somatostatin; Substance P; Synapses | 1982 |
Role of substance P in the antidromic vasodilation, neurogenic plasma extravasation and disruption of the blood-aqueous barrier in the rabbit eye.
Topics: Animals; Aqueous Humor; Blood Pressure; Capillary Permeability; Ciliary Body; Eye; Female; Formaldehyde; Male; Rabbits; Substance P; Vasodilation | 1982 |
Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli.
Topics: Animals; Blood Vessels; Capillary Permeability; Electric Stimulation; Endothelium, Vascular; Formaldehyde; Microcirculation; Microscopy, Electron; Rats; Rats, Inbred F344; Staining and Labeling; Substance P; Trachea; Vagus Nerve; Vasculitis; Venules | 1994 |
Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw.
Topics: Amino Acid Oxidoreductases; Animals; Calcitonin Gene-Related Peptide; DNA-Binding Proteins; Early Growth Response Protein 1; Foot; Formaldehyde; Genes, Immediate-Early; Immediate-Early Proteins; Immunohistochemistry; Male; NADPH Dehydrogenase; Nitric Oxide Synthase; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Transcription Factors; Zinc Fingers | 1994 |
Examination of tonic nociceptive behavior using a method of substance P-receptor desensitization in the dorsal horn.
Topics: Animals; Formaldehyde; Injections, Spinal; Male; Morphine; Naloxone; Nociceptors; Pain Measurement; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; Spinal Cord; Stereotyped Behavior; Substance P; Uric Acid | 1994 |
Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Female; Formaldehyde; Image Processing, Computer-Assisted; Male; Microscopy, Electron; Neuropeptides; Neurotensin; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Substance P | 1994 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neurokinin B; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1995 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylphenethylamine; Pain; Pruritus; Substance P | 1995 |
The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test.
Topics: Animals; Behavior, Animal; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P | 1995 |
CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Formaldehyde; Heart Rate; Hot Temperature; Injections, Spinal; Male; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Stereoisomerism; Substance P | 1993 |
Morphological evidence for the activation of descending modulatory control by nociceptive afferent pathways: an immunocytochemical study.
Topics: Afferent Pathways; Animals; Enkephalin, Methionine; Female; Formaldehyde; Immunohistochemistry; Male; Neurons, Afferent; Neurotensin; Nociceptors; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1993 |
Formalin-induced nociceptive responses in diabetic mice.
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, delta; Substance P | 1993 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Pain Measurement; Postural Balance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Effects of mexiletine on formalin-induced nociceptive responses in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Formaldehyde; Injections, Intraperitoneal; Injections, Spinal; Male; Mexiletine; Mice; Mice, Inbred ICR; Nociceptors; Pain; Somatostatin; Streptozocin; Substance P | 1993 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes | 1993 |
Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.
Topics: Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Mice; Naloxone; Pain; Substance P | 1993 |
The analgesia induced by intrathecal injection of ruthenium red.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain; Pain Measurement; Ruthenium Red; Substance P | 1993 |
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation.
Topics: Amides; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Degranulation; Dextrans; Ear, External; Edema; Endocannabinoids; Ethanolamines; Evans Blue; Excipients; Extravasation of Diagnostic and Therapeutic Materials; Female; Formaldehyde; Hyperalgesia; Male; Mast Cells; Mice; Mice, Inbred BALB C; Palmitic Acids; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Substance P | 1996 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Foot; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils.
Topics: Animals; Female; Foot; Formaldehyde; Gerbillinae; Injections; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Nociceptors; Peptide Fragments; Piperidines; Stereoisomerism; Substance P; Time Factors | 1996 |
Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice.
Topics: Analgesics; Animals; Arginine; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Peptide Fragments; Stereoisomerism; Substance P; Time Factors | 1996 |
LY303870, a centrally active neurokinin-1 antagonist with a long duration of action.
Topics: Animals; Drug Synergism; Electroshock; Formaldehyde; Guinea Pigs; Humans; Indoles; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reflex, Startle; Species Specificity; Spinal Cord; Substance P | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions.
Topics: Amphetamine; Analgesics, Non-Narcotic; Animals; Central Nervous System Stimulants; Formaldehyde; Male; Microinjections; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 1997 |
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Topics: Acetic Acid; Alleles; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Formaldehyde; Ganglia, Spinal; Gene Deletion; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin A; Neurons; Pain; Spinal Cord; Substance P | 1998 |
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Topics: Aggression; Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Female; Formaldehyde; Gene Targeting; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Mutagenesis; Neuritis; Pain; Pain Threshold; Physical Stimulation; Receptors, Neurokinin-1; Stress, Physiological; Substance P | 1998 |
Ginsenosides induce differential antinociception and inhibit substance P induced-nociceptive response in mice.
Topics: Analgesia; Animals; Central Nervous System Agents; Female; Formaldehyde; Ginsenosides; Mice; Nociceptors; Pain; Panax; Plants, Medicinal; Saponins; Substance P | 1998 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan | 1998 |
Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice.
Topics: Amyloid; Animals; Ankle Joint; Behavior, Animal; Calcitonin Gene-Related Peptide; Disinfectants; Formaldehyde; Freund's Adjuvant; Ganglia, Spinal; Islet Amyloid Polypeptide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuritis; Neurons, Afferent; Nociceptors; Somatosensory Cortex; Spinal Cord; Substance P | 1998 |
Evidence for tonic activation of NK-1 receptors during the second phase of the formalin test in the Rat.
Topics: Animals; Autoradiography; Behavior, Animal; Electrophysiology; Formaldehyde; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Male; Neurons; Nociceptors; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin; Spinal Cord; Substance P; Time Factors | 1999 |
Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons.
Topics: Animals; Central Nervous System; Formaldehyde; In Situ Hybridization; Male; Neuritis; Neurons, Afferent; Peripheral Nervous System; Plasmids; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Ribonucleases; RNA Probes; RNA, Messenger; Substance P; Tissue Distribution; Transcription, Genetic | 1999 |
Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hindlimb; Hot Temperature; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Cord; Substance P | 2000 |
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Cholera Toxin; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GTP-Binding Proteins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Neurons; Nociceptors; Pain; Pain Measurement; Pain Threshold; Pertussis Toxin; Spinal Cord; Substance P; Synaptic Transmission; Virulence Factors, Bordetella | 2001 |
Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the rat prostate.
Topics: Adrenergic alpha-Antagonists; Animals; Fixatives; Formaldehyde; Lumbar Vertebrae; Male; Pain; Prostate; Prostatic Diseases; Rats; Rats, Sprague-Dawley; Sacrococcygeal Region; Spinal Cord; Stimulation, Chemical; Substance P; Sulfonamides; Tamsulosin; Up-Regulation | 2002 |
Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Cell Count; Cholera Toxin; Dendrites; Fluorescent Dyes; Formaldehyde; Immunohistochemistry; Male; Microscopy, Confocal; Microscopy, Electron; Neurons; Neurons, Afferent; Pain Measurement; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Stilbamidines; Substance P; Synapses | 2002 |
Modulation of inflammatory paw oedema by cysteamine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Corticotropin-Releasing Hormone; Cystamine; Edema; Formaldehyde; Histamine; Indomethacin; Pyrazoles; Rats; Somatostatin; Substance P; Sulfonamides; Tumor Necrosis Factor-alpha | 2002 |
Evidence for the involvement of glutamatergic receptors in the antinociception caused in mice by the sesquiterpene drimanial.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drimys; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Injections, Spinal; Male; Mice; Morphine; Pain Measurement; Postural Balance; Psychomotor Performance; Receptors, Glutamate; Sesquiterpenes; Substance P | 2002 |
Endomorphin-2 is not released from rat spinal dorsal horn in response to intraplantar formalin.
Topics: Animals; Female; Formaldehyde; Genes, fos; Hindlimb; Male; Oligopeptides; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P | 2002 |
Substance P gene expression in acute experimental colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Muscle, Smooth; Rabbits; Substance P | 1995 |
The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Bites and Stings; Bradykinin; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Formaldehyde; Immobilization; Male; Mice; Pain; Pain Measurement; Peripheral Nervous System; Prostaglandins F; Reflex; Sensitivity and Specificity; Stress, Physiological; Substance P | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P.
Topics: Amino Acid Motifs; Animals; CD4-Positive T-Lymphocytes; Cell Movement; Chemokines; Chemokines, CX3C; CX3C Chemokine Receptor 1; Female; Formaldehyde; Membrane Proteins; Mice; Mice, Inbred BALB C; Pulmonary Eosinophilia; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Chemokine; Respiratory Syncytial Viruses; RNA, Messenger; Substance P; Vaccination; Vaccines, Inactivated; Viral Proteins; Viral Vaccines | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models.
Topics: Administration, Oral; Analgesics; Angelica; Animals; Capsaicin; Cytokines; Excitatory Amino Acids; Formaldehyde; Hot Temperature; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Plant Extracts; Plant Roots; Postural Balance; Reaction Time; Substance P | 2003 |
The influence of inflammation on the expression of neuropeptides in the ileum-projecting primary sensory neurones in the pig.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Formaldehyde; Galanin; Ganglia, Spinal; Ileitis; Ileum; Neurons, Afferent; Neuropeptide Y; Neuropeptides; Polymers; Somatostatin; Substance P; Sus scrofa; Thoracic Vertebrae; Up-Regulation; Vasoactive Intestinal Peptide; Visceral Afferents | 2003 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Reaction Time; Substance P; Thionucleotides | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Increased substance P and tumor necrosis factor-alpha level in the paws following formalin injection in rat tail.
Topics: Animals; Forelimb; Formaldehyde; Hindlimb; Male; Rats; Substance P; Tumor Necrosis Factor-alpha | 2004 |
[Effect of tianyuan ketong recipe on the pain behavior, c-fos expression and P substance contents in dorsal horn of spinal cord in formalin induced pain model rats].
Topics: Analgesics, Non-Narcotic; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Immunohistochemistry; Male; Oncogene Proteins v-fos; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2004 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Histamine; Histidine Decarboxylase; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Histamine H1; Receptors, Neurokinin-1; Substance P; Time Factors | 2005 |
Stellate ganglion block inhibits formalin-induced nociceptive responses: mechanism of action.
Topics: Analgesia; Anesthetics, Local; Animals; Autonomic Nerve Block; Behavior, Animal; Bupivacaine; Formaldehyde; Male; Norepinephrine; Pain; Pain Management; Pain Measurement; Proto-Oncogene Proteins c-fos; Rabbits; Spinal Cord; Stellate Ganglion; Substance P | 2005 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Mexiletine; Motor Activity; Neuralgia; Nitriles; Pain; Pain Measurement; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers; Stress, Mechanical; Substance P; Veratridine | 2006 |
Formalin produces depolarizations in human airway smooth muscle in vitro.
Topics: Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Electrophysiology; Formaldehyde; Humans; In Vitro Techniques; Irritants; Membrane Potentials; Muscle, Smooth; Neuromuscular Depolarizing Agents; Substance P; Trachea | 2006 |
Role of calcitonin gene-related peptide and substance P in different models of pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Lumbosacral Region; Male; Nitroglycerin; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Caudal Nucleus | 2008 |
The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains.
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Blotting, Western; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Immunohistochemistry; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Paraventricular Hypothalamic Nucleus; Substance P | 2008 |
The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Pain Measurement; Substance P | 2008 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-1; Substance P | 2008 |
Substance P expression in the distal cerebrospinal fluid-contacting neurons and spinal trigeminal nucleus in formalin-induced the orofacial inflammatory pain in rats.
Topics: Animals; Facial Pain; Formaldehyde; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Microscopy, Immunoelectron; Neurons; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Nucleus, Spinal | 2009 |
Development of mechanisms associated with neurogenic-mediated skin inflammation during the growth of rats.
Topics: Age Factors; Animals; Capsaicin; Cell Degranulation; Female; Fixatives; Formaldehyde; Male; Mast Cells; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory System Agents; Skin; Substance P | 2010 |
Antinociceptive effect of vinpocetine--a comprehensive survey.
Topics: Acid Phosphatase; Analgesics; Animals; Calcitonin Gene-Related Peptide; Densitometry; Formaldehyde; Male; Nerve Growth Factor; Neuroprotective Agents; Pain; Pain Measurement; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Spinal Cord; Substance P; Vinca Alkaloids | 2010 |
TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.
Topics: Acetanilides; Acrolein; Animals; Animals, Newborn; Ankyrins; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Garlic; Laser-Doppler Flowmetry; Meningeal Arteries; Mustard Plant; Neurons; Peptide Fragments; Plant Oils; Purines; Rats; Sensory System Agents; Substance P; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; Vasodilation | 2011 |
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
Topics: Androstadienes; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Formaldehyde; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Male; Nerve Tissue Proteins; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reaction Time; Signal Transduction; Sirolimus; Spinal Cord; Statistics, Nonparametric; Substance P; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2011 |
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
Topics: Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Knockout; Neurons; Neurons, Afferent; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Tachykinins | 2011 |
Knockdown of the tachykinin neurokinin 1 receptor by intrathecal administration of small interfering RNA in rats.
Topics: Animals; Base Sequence; Behavior, Animal; Carrageenan; Formaldehyde; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Vectors; Hyperalgesia; Inflammation; Injections, Spinal; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Small Interfering; Sendai virus; Spinal Cord; Substance P | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
Pharmacological characteristics of endokinin C/D-derived peptides in nociceptive and inflammatory processing in rats.
Topics: Amino Acid Sequence; Amino Acids; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Formaldehyde; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Nociceptive Pain; Pain Measurement; Peptide Fragments; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins; Time Factors; Tryptophan | 2011 |
Effect of exposure to volatile organic compounds (VOCs) on airway inflammatory response in mice.
Topics: Administration, Inhalation; Air Pollution, Indoor; Animals; Benzene; Bronchoalveolar Lavage Fluid; China; Formaldehyde; Interferon-gamma; Interleukin-6; Lung; Male; Mice; Mice, Inbred Strains; Neurotrophin 3; Oxidative Stress; Pneumonia; Reactive Oxygen Species; Signal Transduction; Substance P; Toluene; Volatile Organic Compounds; Xylenes | 2012 |
Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Biological Transport; Capsaicin; Cells, Cultured; Chlorides; Colforsin; Epinephrine; Epithelial Cells; Formaldehyde; Imines; Male; Nerve Endings; ortho-Aminobenzoates; Quinuclidines; Rats; Respiratory Mucosa; Substance P; Trachea; TRPV Cation Channels | 2013 |
Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor.
Topics: Analgesia; Animals; Biphenyl Compounds; Corpus Striatum; Formaldehyde; Genes, fos; Genes, Immediate-Early; Injections; Male; Neurokinin-1 Receptor Antagonists; Nociception; Protein Precursors; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Time Factors; Up-Regulation | 2013 |
Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord.
Topics: Acute Disease; Animals; Colitis; Colon; Formaldehyde; Gene Expression; Lumbosacral Region; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Nociceptive Pain; Protein Transport; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tryptophan | 2013 |
Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice.
Topics: Acetanilides; Animals; Asthma; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Immunoglobulin E; Immunohistochemistry; Interleukin-1beta; Interleukin-4; Interleukin-6; Lung; Male; Mice; Mice, Inbred BALB C; Neuropeptides; Ovalbumin; Purines; Substance P; Transient Receptor Potential Channels | 2013 |
Antinociceptive profiles and mechanisms of orally administered coumarin in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Coumarins; Formaldehyde; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Receptors, Opioid; Substance P | 2013 |
Sex differences in formalin-evoked primary afferent release of substance P.
Topics: Animals; Estradiol; Estrous Cycle; Female; Fluorescent Antibody Technique; Formaldehyde; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Microscopy, Confocal; Neurons, Afferent; Orchiectomy; Ovariectomy; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Sex Characteristics; Substance P | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; Pain; Proto-Oncogene Proteins c-fos; Pruritus; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Substance P; Tachykinins | 2014 |
Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Disease Models, Animal; Formaldehyde; Male; Medulla Oblongata; Microglia; Neural Pathways; Neurons; Neurotensin; Nitric Oxide Synthase; Pain; Parvalbumins; Periaqueductal Gray; Rats, Sprague-Dawley; Receptor, trkB; RNA, Messenger; Serotonin; Substance P; Tyrosine Decarboxylase | 2014 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Male; Mice, Inbred ICR; Nociception; Oxyntomodulin; Pain; Rotarod Performance Test; Spinal Cord; Substance P | 2018 |