substance p (6-11), arg(6)-trp(7,9)-me-phe(8)- and substance p

substance p (6-11), arg(6)-trp(7,9)-me-phe(8)- has been researched along with substance p in 20 studies

Compound Research Comparison

Studies (substance p (6-11), arg(6)-trp(7,9)-me-phe(8)-)	Trials (substance p (6-11), arg(6)-trp(7,9)-me-phe(8)-)	Recent Studies (post-2010) (substance p (6-11), arg(6)-trp(7,9)-me-phe(8)-)	Studies (substance p)	Trials (substance p)	Recent Studies (post-2010) (substance p)
20	0	1	17,289	277	2,010

Protein Interaction Comparison

Protein	Taxonomy	substance p (IC50)
Substance-P receptor	Rattus norvegicus (Norway rat)	0.0005
Substance-K receptor	Rattus norvegicus (Norway rat)	0.2
Substance-K receptor	Homo sapiens (human)	0.2455
Substance-P receptor	Homo sapiens (human)	0.0011
Neuromedin-K receptor	Homo sapiens (human)	0.125
Substance-K receptor	Mesocricetus auratus (golden hamster)	0.148

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (5.00)	18.7374
1990's	14 (70.00)	18.2507
2000's	4 (20.00)	29.6817
2010's	1 (5.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Langdon, S; Muir, M; Ritchie, A; Rozengurt, E; Sethi, T; Smyth, J	1
Rozengurt, E; Woll, PJ	1
Chorev, M; Friedman, ZY; Gilon, C; Laufer, R; Selinger, Z; Wormser, U	1
Cummings, J; Langdon, SP; MacLellan, A; Rozengurt, E; Smyth, JF	1
Cummings, J; Langdon, SP; MacLellan, A; Smyth, JF	1
Beijnen, JH; Bult, A; Koster, EH; Reubsaet, JL; Teeuwsen, J; Underberg, WJ; Waterval, JC	1
Freemont, PS; Newman, RH; Rozengurt, E; Seckl, MJ	1
Cummings, J; Jones, DA; Langdon, SP; MacLellan, AJ; Rozengurt, E; Smyth, JF	1
Beijnen, JH; Bult, A; Koster, EH; Reubsaet, JL; Teeuwsen, J; Underberg, WJ; van der Houwen, OA	1
Cummings, J; Higgins, T; Jones, DA; Langdon, SP; Maclellan, AJ; Rozengurt, E; Smyth, JF	1
Rozengurt, E; Seckl, MJ	1
Bult, A; Cui, H; Reubsaet, JL	1
Beijnen, JH; Bult, A; Henrar, RE; Jonkman-de Vries, JD; Kettenes-van den Bosch, JJ; Rosing, H; Talsma, H	1
Cummings, J; Jodrell, DI; MacLellan, AJ; Mark, M	1
Beijnen, JH; Belshof, EH; Bouyakhrichan, M; Bult, A; Hop, E; Kellekule, Y; Reubsaet, JL; Teeuwsen, J; Underberg, WJ; van Maanen, RJ	1
MacKinnon, A; Sethi, T	1
Buckley, A; Chilvers, ER; Haslett, C; MacKinnon, AC; Rossi, AG; Sethi, T	1
Cummings, J; Haslett, C; Jodrell, D; MacKinnon, AC; Sethi, T; Tufail-Hanif, U; Waters, CM	1
Haslett, C; MacKinnon, AC; Rossi, AG; Seckl, M; Sethi, T; Tufail-Hanif, U; Wheatley, M	1
Li, JS; Liu, CX; Liu, SH; Wang, JD; Wang, XJ; Xiang, WS; Zhang, J; Zhao, JW	1

Other Studies

20 other study(ies) available for substance p (6-11), arg(6)-trp(7,9)-me-phe(8)- and substance p

Article	Year
Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer research, 1992, Aug-15, Volume: 52, Issue:16 Topics: Animals; Calcium; Carcinoma, Small Cell; Drug Screening Assays, Antitumor; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Peptide Fragments; Signal Transduction; Substance P; Tumor Cells, Cultured	1992
A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer research, 1990, Jul-01, Volume: 50, Issue:13 Topics: Animals; Bradykinin; Calcium; Carcinoma, Small Cell; Cell Division; Cells, Cultured; DNA, Neoplasm; Drug Screening Assays, Antitumor; Gastrin-Releasing Peptide; Humans; Lung Neoplasms; Mice; Peptide Fragments; Peptides; Recombinant Proteins; Substance P; Tumor Cells, Cultured; Vasopressins	1990
Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:21 Topics: Animals; Atropine; Enkephalin, Methionine; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth; Naloxone; Nerve Tissue Proteins; Neurokinin A; Neurokinin B; Neurons; Neurotransmitter Agents; Oligopeptides; Peptide Fragments; Receptors, Muscarinic; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Substrate Specificity; Tachykinins	1985
Determination of two neuropeptide growth factor antagonists, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P and [Arg6,D-Trp7,9,N-MePhe8]- substance P(6-11), by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical applications, 1994, Mar-04, Volume: 653, Issue:2 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Electrochemistry; Growth Inhibitors; Humans; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Transplantation; Peptide Fragments; Substance P; Tryptophan	1994
Stability and in vitro metabolism of the mitogenic neuropeptide antagonists [D-Arg1,D-Phe5, D-Trp7,9, Leu11]-substance P and [Arg6, D-Trp7,9, MePhe8]-substance P (6-11) characterized by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:6 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Drug Stability; Half-Life; Humans; In Vitro Techniques; Liver; Mice; Mice, Nude; Molecular Sequence Data; Peptide Fragments; Substance P	1994
Reversed-phase high-performance liquid chromatography and capillary electrophoresis in the stability study of the neuropeptide growth factor antagonist [Arg6,D-Trp7,9,MePhe8]-substance P (6-11): a comparative study. Analytical biochemistry, 1994, Volume: 220, Issue:1 Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Drug Stability; Electrophoresis; Kinetics; Molecular Sequence Data; Molecular Structure; Nerve Growth Factors; Peptide Fragments; Substance P	1994
Substance P-related antagonists inhibit vasopressin and bombesin but not 5'-3-O-(thio)triphosphate-stimulated inositol phosphate production in Swiss 3T3 cells. Journal of cellular physiology, 1995, Volume: 163, Issue:1 Topics: 3T3 Cells; Aluminum Compounds; Amino Acid Sequence; Animals; Bombesin; Cell Line, Transformed; Dose-Response Relationship, Drug; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Liver; Mice; Molecular Sequence Data; Peptide Fragments; Rats; Substance P; Vasopressins	1995
Processing of the neuropeptide growth factor antagonist [Arg6, D-Trp7.9, NmePhe8]-substance P (6-11) by a small cell lung cancer cell line (H69). Biochemical pharmacology, 1995, May-26, Volume: 49, Issue:11 Topics: Antineoplastic Agents; Carcinoma, Small Cell; Cell Line; Chromatography, High Pressure Liquid; Culture Media; Humans; Lung Neoplasms; Peptide Fragments; Substance P; Time Factors	1995
Degradation kinetics of antagonist [Arg6, D-Trp7,9, MePhe8]-substance P [6-11] in aqueous solutions. Analytical biochemistry, 1995, May-20, Volume: 227, Issue:2 Topics: Buffers; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Kinetics; Logistic Models; Osmolar Concentration; Peptide Fragments; Solutions; Substance P; Temperature; Water	1995
Metabolism of the broad-spectrum neuropeptide growth factor antagonist: [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P. British journal of cancer, 1996, Volume: 73, Issue:6 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Bombesin; Drug Stability; Liver; Mice; Molecular Sequence Data; Peptide Fragments; Phenylmethylsulfonyl Fluoride; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Substance P	1996
Effect of tyrphostin combined with a substance P related antagonist on small cell lung cancer cell growth in vitro. European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:2 Topics: Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lung Neoplasms; Neoplastic Stem Cells; Nitriles; Peptide Fragments; Protein-Tyrosine Kinases; Signal Transduction; Substance P; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins	1996
Precolumn fluorescence derivatization of the antagonist [Arg6,D-Trp7,9,MePhe8]-substance P[6-11] with benzoin in high-performance liquid chromatography and selective detection of arginine-containing fragments in its degradation products. Journal of chromatography. A, 1996, Jun-07, Volume: 736, Issue:1-2 Topics: Amino Acid Sequence; Arginine; Benzoin; Chromatography, High Pressure Liquid; Fluorescent Dyes; Indicators and Reagents; Molecular Sequence Data; Peptide Fragments; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substance P	1996
Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11]. Investigational new drugs, 1998, Volume: 16, Issue:2 Topics: Amino Acid Sequence; Antineoplastic Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Freeze Drying; Infusions, Parenteral; Magnetic Resonance Spectroscopy; Molecular Structure; Neuropeptides; Oxidation-Reduction; Peptide Fragments; Substance P	1998
Development of a gradient elution high-performance liquid chromatography assay with ultraviolet detection for the determination in plasma of the anticancer peptide [Arg6, D-Trp7,9, mePhe8]-substance P (6-11) (antagonist G), its major metabolites and a C-t Journal of chromatography. B, Biomedical sciences and applications, 1999, Sep-24, Volume: 732, Issue:2 Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Fluorescence; Humans; Peptide Fragments; Pyrenes; Reproducibility of Results; Spectrophotometry, Ultraviolet; Substance P	1999
Qualitative and quantitative aspects of the degradation of several tripeptides derived from the antitumour peptide antagonist [Arg(6), D-Trp(7,9), MePhe(8)] substance P[6-11]. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 19, Issue:3-4 Topics: Antineoplastic Agents; Arginine; Chromatography, High Pressure Liquid; Diketopiperazines; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mass Spectrometry; Peptide Fragments; Phenylalanine; Piperazines; Substance P	1999
[D-Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism. Methods in molecular medicine, 2003, Volume: 74 Topics: Apoptosis; Carcinoma, Small Cell; Cell Division; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Peptide Fragments; Precipitin Tests; Substance P; Time Factors; Tumor Cells, Cultured	2003
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. Journal of immunology (Baltimore, Md. : 1950), 2002, Dec-01, Volume: 169, Issue:11 Topics: Adult; Apoptosis; Calcium Signaling; Cell Polarity; Cell Size; Chromones; Enzyme Activation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Recombinant Proteins; Respiratory Burst; Signal Transduction; Sphingosine; Substance P; Superoxides; Tumor Necrosis Factor-alpha	2002
Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition. British journal of cancer, 2003, Jun-02, Volume: 88, Issue:11 Topics: Animals; Antineoplastic Agents; Bradykinin; Calcium; Carcinoma, Small Cell; Cell Division; DNA, Neoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fibroblasts; Gastrin-Releasing Peptide; Humans; Lung Neoplasms; Mice; Mice, Nude; Peptide Fragments; Rats; Receptors, Bombesin; Receptors, Neuropeptide; Substance P; Transplantation, Heterologous; Tumor Cells, Cultured; Vasopressins	2003
Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies. British journal of pharmacology, 2009, Volume: 156, Issue:1 Topics: Animals; Antineoplastic Agents; Arginine Vasopressin; Calcium; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; Humans; Lung Neoplasms; Peptide Fragments; Pertussis Toxin; Receptors, Bombesin; Receptors, Vasopressin; Signal Transduction; Substance P; Type C Phospholipases	2009
A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5. Journal of Asian natural products research, 2017, Volume: 19, Issue:9 Topics: Animals; Antineoplastic Agents; Ants; Drug Screening Assays, Antitumor; HCT116 Cells; Hep G2 Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Pyrones; Streptomyces; Substance P	2017