su-1498 and 1-1-diethyl-2-hydroxy-2-nitrosohydrazine

Impairment of flow-induced vasodilation in coronary resistance arterioles may contribute to the decline in coronary vasodilatory reserve that occurs with advancing age. This study investigated the effects of age on flow-induced signaling and activation of nitric oxide (NO)-mediated vasodilation in coronary resistance arterioles. Coronary arterioles were isolated from young (approximately 6 mo) and old (approximately 24 mo) male Fischer-344 rats to assess vasodilation to flow, vascular endothelial growth factor (VEGF), and ACh. Flow- and VEGF-induced vasodilation of coronary arterioles was impaired with age (P

Topics: Acetylcholine; Age Factors; Aging; Androstadienes; Animals; Arterioles; Blood Flow Velocity; Cinnamates; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Stress, Mechanical; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vasodilation; Vasodilator Agents; Wortmannin