styrene oxide has been researched along with styrene in 125 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 27 (21.60) | 18.7374 |
1990's | 39 (31.20) | 18.2507 |
2000's | 39 (31.20) | 29.6817 |
2010's | 17 (13.60) | 24.3611 |
2020's | 3 (2.40) | 2.80 |
Authors | Studies |
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Barale, R | 1 |
Doane-Setzer, P; Rappaport, SM; Smith, MT; Ting, D; Woodlee, J | 1 |
Filser, JG; Jiang, XL; Kessler, W | 1 |
Bodell, WJ; Burlingame, AL; Kaur, S; Liu, SF; Pongracz, K; Rappaport, SM | 1 |
Djurhuus, R; Lillehaug, JR; Male, R; Pryme, IF | 1 |
Higashi, K; Inoue, N; Katoh, T | 1 |
Fujishiro, K; Inoue, N; Mori, K | 1 |
Ciliberti, A; Conti, B; Maltoni, C; Perino, G | 1 |
Gill, SS; Grayson, MH | 1 |
Catalano, CE; Choe, YS; DePillis, G; Ortiz de Montellano, PR | 1 |
Fujita, H; Hayashi, N; Ikeda, M; Koizumi, A | 1 |
Fujita, H; Furusawa, T; Ikeda, M; Koizumi, A | 1 |
Bend, JR; Harris, C; Hernandez, O; Philpot, RM | 1 |
Husain, R; Seth, PK; Srivastava, SP; Zaidi, NF | 1 |
Byfält Nordqvist, M; Löf, A; Osterman-Golkar, S; Walles, SA | 1 |
Belvedere, G; Tursi, F | 2 |
Pohlová, H; Rössner, P; Srám, RJ | 1 |
Gullstrand, E; Löf, A; Lundgren, E; Nordqvist, MB | 1 |
Belvedere, G; Elovaara, E; Vainio, H | 1 |
Belvedere, G; Hietanen, E; Talve, L; Vainio, H | 1 |
Fregert, S; Sjöborg, S; Trulsson, L | 1 |
Huff, JE | 1 |
Norppa, H; Sorsa, M; Vainio, H | 1 |
Bianchi, M; Lascialfari, D; Loprieno, N; Pantarotto, C; Rossi, AM; Sbrana, I; Tortoreto, M | 1 |
Belvedere, G; Blezza, D; Cantoni, L | 1 |
Beije, B; Jenssen, D | 1 |
Ozawa, N; Watabe, T; Yoshikawa, K | 2 |
Mackenzie, P; Vainio, H | 1 |
Delbressine, LP; Seutter-Berlage, F; Smeets, FL; Van Bladeren, PJ | 1 |
Preston, RJ; Scott, D | 1 |
Buckley, CM; Dobson, AD; Hartmans, S; O'Connor, K | 1 |
Christakopoulos, A; Osterman-Golkar, S; Svensson, K; Zorcec, V | 1 |
Kirsch-Volders, M; Pauwels, W; Roosels, D; Severi, M; Van Hummelen, P; Veulemans, H | 1 |
Filser, JG; Gfrörer, W; Kessler, W; Korn, M | 1 |
Roe, FJ | 1 |
Farmer, PB; Phillips, DH | 1 |
McConnell, EE; Swenberg, JA | 2 |
Durham, H; Kohn, J; Minotti, S | 1 |
Leak, DJ; Matthews, CS; Rigby, SR | 1 |
Csanády, GA; Filser, JG; Mendrala, AL; Nolan, RJ | 1 |
Bodell, WJ; Horvath, E; Pongracz, K; Rappaport, S | 1 |
Costa, LG; Faustman, EM; Gregotti, CF; Kirby, Z; Manzo, L | 1 |
Chakrabarti, S; Duhr, MA; Richer, CL; Senécal-Quevillon, M | 1 |
Langvardt, PW; Mendrala, AL; Nitschke, KD; Nolan, RJ; Quast, JF | 1 |
Lee, SH; Norppa, H | 1 |
Carlson, GP; DeNicola, DB; Gadberry, MG | 1 |
Jin, Z; Rappaport, SM; Yeowell-O'Connell, K | 1 |
Dobson, AD; Duetz, W; O'Connor, K; Wind, B | 1 |
Bodell, W; Rappaport, SM; Symanski, E; Yager, JW; Yeowell-O'Connell, K | 1 |
Capodaglio, E; Cavalleri, A; Ghittori, S; Gobba, F; Imbriani, M; Maestri, L | 1 |
Bond, JA; Farris, GM; James, RA; Leavens, TL; Marshall, MW; Shah, R; Wong, VA | 1 |
Carlson, GP | 6 |
Jin, Z; Pauwels, W; Rappaport, SM; Severi, M; Veulemans, H; Walker, MR; Yeowell-O'Connell, K | 1 |
Bailey, E; Cordero, R; Farmer, PB; Osterman-Golkar, S; Pauwels, W; Severi, M; Veulemans, H | 1 |
Colombi, A; Colosio, C; Fustinoni, S; Lastrucci, L; Rappaport, SM; Yeowell-O'Connell, K | 1 |
Linhart, I; Mládková, I; Smejkal, J | 1 |
Panke, S; Schmid, A; Witholt, B; Wubbolts, MG | 1 |
Hellman, B; Vaghef, H | 1 |
Chakrabarti, SK | 1 |
Kupper, LL; Nylander-French, LA; Rappaport, SM | 1 |
Bluhm, S; Harris, CM; Harris, TM; Painter, SL; Stone, MP; Tamura, PJ; Zegar, IS | 1 |
Rappaport, SM; Yeowell-O'Connell, K | 1 |
Carlson, GP; DeNicola, DB; Hynes, DE | 1 |
Gut, I; Linhart, I; Novák, J; Smejkal, J | 1 |
Carlson, GP; Mantick, NA; Powley, MW | 1 |
Ernstgård, L; Gullstrand, E; Johanson, G; Löf, A; Osterman-Golkar, S; Sumner, SC; Williams, CC | 1 |
Andreoli, R; Bergamaschi, E; De Palma, G; Manini, P; Mutti, A; Niessen, WM | 1 |
Lau, PC; Nishio, T; Patel, A; Wang, Y | 1 |
Echeverria, D; Osterman-Golkar, S; Pérez, HL; Rappaport, SM; Tornero-Velez, R; Waidyanatha, S | 1 |
Foster, J; Green, T; Lee, R; Lund, V; Meadowcroft, S; Toghill, A | 1 |
Bárta, I; Hemminki, K; Koskinen, M; Smerák, P; Stetina, R; Vodicka, P; Vodicková, L | 1 |
Andreoli, R; Bergamaschi, E; Cavazzini, S; De Palma, G; Franchini, I; Manini, P; Mozzoni, P; Mutti, A | 1 |
Rappaport, SM; Tornero-Velez, R | 2 |
Csanády, GA; Filser, JG; Kessler, W | 1 |
Lutz, U; Lutz, WK; Otteneder, M | 1 |
Arand, M; Hemminki, K; Koskinen, M; Oesch, F; Vodicka, P | 1 |
Andersen, ME; Clewell, HJ; Cruzan, G; Sarangapani, R; Teeguarden, JG | 1 |
Held, M; Panke, S; Schmid, A; Witholt, B; Wubbolts, MG | 1 |
Estavillo, C; Rusling, JF; Schenkman, JB; Stuart, JD; Yang, J; Zhou, L | 1 |
Csanády, GA; Filser, JG; Hoffmann, HD; Kessler, W | 1 |
Carlson, G | 1 |
Hofstetter, K; Otto, K; Röthlisberger, M; Schmid, A; Witholt, B | 1 |
Carlson, GP; Mantick, NA; Turner, M | 2 |
de Visser, SP; Kumar, D; Shaik, S | 1 |
Kaufmann, W; Landsiedel, R; Mellert, W; Poole, A; van Ravenzwaay, B | 1 |
Csanády, GA; Faller, TH; Filser, JG; Hofmann, C; Pütz, C; Semder, B | 1 |
Arany, S; Hirasawa, F; Kawagoe, M; Koizumi, Y; Sugiyama, T; Ueno, Y | 1 |
Echeverria, D; Kupper, LL; Nylander-French, LA; Rappaport, SM; Serdar, B; Tornero-Velez, R | 1 |
Bühler, B; Habicher, T; Hauer, B; Panke, S; Park, JB; Schmid, A; Witholt, B | 1 |
Chung, JK; Liu, G; Yuan, W; Zheng, J | 1 |
Carlson, GP; Harvilchuck, JA | 2 |
Costa, C; Farmer, PB; Gaspar, J; Mayan, O; Roach, J; Roma-Torres, J; Rueff, J; Silva, S; Teixeira, JP | 1 |
Farmer, PB; Gaspar, J; Mayan, O; Roach, J; Rueff, J; Silva, S; Teixeira, JP; Torres, J | 1 |
Gross, R; Hauer, B; Otto, K; Schmid, A | 1 |
Buratti, M; Campo, L; Colombi, A; De Palma, G; Foa, V; Fustinoni, S; Manini, P; Mutti, A; Rappaport, SM; Waidyanatha, S | 1 |
Alexandrova, E; Anderson, D; Cemeli, E; Chiuchiarelli, G; Mirkova, E | 1 |
Eulberg, D; Kaschabek, SR; Lakner, S; Schlömann, M; Tischler, D; van Berkel, WJ | 1 |
Carlson, GP; Harvilchuck, JA; Klaunig, JE; Pu, X | 1 |
Chung, JK; Jin, H; Yuan, W; Zheng, J | 1 |
Bennett, B; Fung, LW; Horner, JH; Newcomb, M; Sheng, X; Yuan, X | 1 |
Banton, M; Bus, J; Cruzan, G; Harkema, J; Hotchkiss, J; Sarang, S | 1 |
Cosnier, F; Cossec, B; Gaté, L; Nunge, H | 1 |
Binet, S; Cosnier, F; Darne, C; Gaté, L; Guichard, Y; Langlais, C; Micillino, JC; Nunge, H; Sébillaud, S | 1 |
Bühler, B; Kuhn, D; Schmid, A | 1 |
Banton, M; Bus, J; Cruzan, G; Hotchkiss, J; Moore, C; Sarang, S; Sura, R; Yost, G | 1 |
Ding, X; Li, L; Shen, S; Zheng, J | 1 |
Buehler, K; Halan, B; Karande, R; Schmid, A | 1 |
Bühler, B; Neumann, C; Schmid, A; Volmer, J | 1 |
Filser, JG; Gelbke, HP | 1 |
Bin, P; Dai, Y; Ji, Y; Meng, T; Miao, P; Niu, Y; Zheng, Y | 1 |
Williamson, J | 1 |
Doukyu, N; Iida, S | 1 |
Huang, H; Lv, J; Meng, XG; Wang, F; Wu, YY; Yu, WW | 1 |
Delgado, E; Pecchi, G; Saavedra-Torres, M; Schott, E; Toledo, F; Zarate, X | 1 |
7 review(s) available for styrene oxide and styrene
Article | Year |
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The genetic toxicology of styrene and styrene oxide.
Topics: Animals; Epoxy Compounds; Humans; Mutagens; Plants; Styrene; Styrenes | 1991 |
A re-evaluation of the cytogenetic effects of styrene.
Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; Micronuclei, Chromosome-Defective; Sister Chromatid Exchange; Styrene; Styrenes | 1994 |
Styrene: toxicity studies--what do they show?
Topics: Animals; Carcinogenicity Tests; Carcinogens; Environmental Pollution; Epoxy Compounds; Humans; Mutagenicity Tests; Mutagens; Occupational Exposure; Reproduction; Styrene; Styrenes | 1994 |
Evidence for DNA and protein binding by styrene and styrene oxide.
Topics: Animals; DNA Adducts; Epoxy Compounds; Hemoglobins; Humans; Mutagens; Neoplasms; Occupational Exposure; Protein Binding; Styrene; Styrenes | 1994 |
Review of styrene and styrene oxide long-term animal studies.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Epoxy Compounds; Styrene; Styrenes; Time Factors | 1994 |
Styrene and styrene oxide: results of studies on carcinogenicity in experimental animals.
Topics: Animals; Carcinogens; Epoxy Compounds; Female; Male; Neoplasms, Experimental; Styrene; Styrenes | 1993 |
Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring.
Topics: Animals; Binding Sites; Biomarkers; DNA; DNA Adducts; Environmental Monitoring; Epoxy Compounds; Humans; In Vitro Techniques; Mutagens; Occupational Exposure; Risk Assessment; Styrene | 2002 |
2 trial(s) available for styrene oxide and styrene
Article | Year |
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Styrene-7,8-oxide in blood of workers exposed to styrene.
Topics: Adult; Chromatography, Gas; Epoxy Compounds; Germany; Humans; Linear Models; Male; Middle Aged; Occupational Exposure; Styrene; Styrenes | 1994 |
Albumin and hemoglobin adducts as biomarkers of exposure to styrene in fiberglass-reinforced-plastics workers.
Topics: Adult; Albumins; Analysis of Variance; Biomarkers; Carcinogens; Chemical Industry; Chromatography, High Pressure Liquid; Environmental Monitoring; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Glass; Glyoxylates; Hemoglobins; Humans; Linear Models; Male; Mandelic Acids; Occupational Exposure; Plastics; Sensitivity and Specificity; Styrene; Styrenes | 1998 |
116 other study(ies) available for styrene oxide and styrene
Article | Year |
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Measurement of styrene-oxide cysteine adducts in hemoglobin by selective catalytic reduction.
Topics: Alkylation; Animals; Cysteine; Epoxy Compounds; Erythrocytes; Globins; Hemoglobins; Humans; In Vitro Techniques; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Styrene; Styrenes | 1991 |
Direct determination of styrene-7,8-oxide in blood by gas chromatography with flame ionization detection.
Topics: Animals; Atmosphere Exposure Chambers; Epoxy Compounds; Flame Ionization; Male; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Styrene; Styrenes | 1990 |
Investigation of styrene oxide-DNA adducts and their detection in workers exposed to styrene.
Topics: DNA; Environmental Exposure; Epoxy Compounds; Ethers, Cyclic; Humans; Lymphocytes; Occupations; Styrene; Styrenes | 1990 |
In vitro transformation and tumor promotion studies of styrene and styrene oxide.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Choline; Cocarcinogenesis; DNA; Endoplasmic Reticulum; Epoxy Compounds; Ethers, Cyclic; Fibroblasts; Methylcholanthrene; Mice; Neoplasms, Experimental; RNA; Styrene; Styrenes | 1985 |
Sub-chronic effects of styrene and styrene oxide on lipid peroxidation and the metabolism of glutathione in rat liver and brain.
Topics: Animals; Brain; Epoxy Compounds; Ethers, Cyclic; Glutathione; Glutathione Disulfide; Glutathione Reductase; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Rats; Rats, Inbred Strains; Styrene; Styrenes | 1989 |
[Inhibition of delta-aminolevulinic acid dehydratase by styrene and styrene oxide].
Topics: Animals; Epoxy Compounds; Erythrocytes; Ethers, Cyclic; Liver; Male; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Styrene; Styrenes | 1988 |
Long-term carcinogenicity bioassays on styrene administered by inhalation, ingestion and injection and styrene oxide administered by ingestion in Sprague-Dawley rats, and para-methylstyrene administered by ingestion in Sprague-Dawley rats and Swiss mice.
Topics: Administration, Inhalation; Administration, Oral; Animals; Biological Assay; Epoxy Compounds; Ethers, Cyclic; Injections, Intravenous; Mammary Neoplasms, Experimental; Mice; Rats; Rats, Inbred Strains; Stomach Neoplasms; Styrene; Styrenes | 1988 |
Effect of in vitro exposure to styrene, styrene oxide, and other structurally related compounds on murine cell-mediated immunity.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; DNA Replication; Epoxy Compounds; Ethers, Cyclic; Female; Immunity, Cellular; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Spleen; Structure-Activity Relationship; Styrene; Styrenes; T-Lymphocytes, Cytotoxic | 1986 |
Structure-mechanism relationships in hemoproteins. Oxygenations catalyzed by chloroperoxidase and horseradish peroxidase.
Topics: Acetaldehyde; Animals; Chemical Phenomena; Chemistry; Chloride Peroxidase; Cytochrome P-450 Enzyme System; Epoxy Compounds; Hemeproteins; Horseradish Peroxidase; Magnetic Resonance Spectroscopy; Microsomes, Liver; Oxygen; Peroxidases; Rats; Structure-Activity Relationship; Styrene; Styrenes | 1987 |
Reduced synthesis of 5-aminolevulinate dehydratase in styrene-treated rats.
Topics: Animals; Cell-Free System; Depression, Chemical; Epoxy Compounds; Erythrocytes; Liver; Male; Porphobilinogen Synthase; Protein Processing, Post-Translational; Rats; Rats, Inbred Strains; RNA, Messenger; Styrene; Styrenes; Transcription, Genetic | 1986 |
Decreased erythrocyte delta-aminolevulinate dehydratase activity after styrene exposure.
Topics: Animals; Bone Marrow; Environmental Exposure; Epoxy Compounds; Erythrocytes; Glutathione; Humans; Male; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Styrene; Styrenes | 1987 |
Rabbit pulmonary cytochrome P-450 monooxygenase system: isozyme differences in the rate and stereoselectivity of styrene oxidation.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Epoxy Compounds; Glutathione; In Vitro Techniques; Isoenzymes; Lung; Male; Microsomes; Oxidation-Reduction; Oxygenases; Rabbits; Stereoisomerism; Styrene; Styrenes | 1986 |
Effect of styrene oxide on levels of biogenic amines and activity of monoamine oxidase in different parts of rat brain.
Topics: Animals; Biogenic Amines; Brain Chemistry; Epoxy Compounds; Ethers, Cyclic; Male; Monoamine Oxidase; Rats; Styrene; Styrenes | 1985 |
Covalent binding of styrene and styrene-7,8-oxide to plasma proteins, hemoglobin and DNA in the mouse.
Topics: Alkylating Agents; Alkylation; Animals; Blood Proteins; DNA; Dose-Response Relationship, Drug; Epoxy Compounds; Ethers, Cyclic; Hemoglobins; Liver; Male; Mice; Styrene; Styrenes | 1985 |
Styrene oxidation to styrene oxide by hydroxyl radicals produced during reaction of xanthine with xanthine oxidase in the presence of Fe3+.
Topics: Chemical Phenomena; Chemistry; Epoxy Compounds; Ethers, Cyclic; Ferric Compounds; Free Radicals; Hydroxides; Hydroxyl Radical; Oxidation-Reduction; Styrene; Styrenes; Xanthine; Xanthine Oxidase; Xanthines | 1983 |
Cytogenetic analysis of human peripheral blood lymphocytes in culture exposed in vitro to styrene and styrene oxide.
Topics: Adult; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Epoxy Compounds; Ethers, Cyclic; Female; Humans; Lymphocytes; Sister Chromatid Exchange; Styrene; Styrenes; Thiotepa | 1984 |
Occurrence of styrene-7,8-oxide and styrene glycol in mouse after the administration of styrene.
Topics: Animals; Epoxy Compounds; Ethers, Cyclic; Ethylene Glycols; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Styrene; Styrenes; Tissue Distribution | 1984 |
Activation of styrene to styrene oxide in hepatocytes and subcellular fractions of rat liver.
Topics: Animals; Cell Survival; Epoxy Compounds; Ethers, Cyclic; Ethylene Glycols; Glutathione; Liver; Male; NADP; Rats; Rats, Inbred Strains; Styrene; Styrenes; Subcellular Fractions; Time Factors | 1984 |
Effect of blood on styrene oxidation in perfused rat liver.
Topics: Animals; Biotransformation; Epoxy Compounds; Erythrocytes; Ethylene Glycols; Liver; Oxidation-Reduction; Oxyhemoglobins; Perfusion; Rats; Styrene; Styrenes | 1984 |
Contact allergy to styrene and related chemicals.
Topics: Dermatitis, Atopic; Dermatitis, Contact; Epoxy Compounds; Food Hypersensitivity; Haptens; Humans; Patch Tests; Phenols; Styrene; Styrenes | 1984 |
Styrene, styrene oxide, polystyrene, and beta-nitrostyrene/styrene carcinogenicity in rodents.
Topics: Animals; Carcinogens; Chemical Industry; Epoxy Compounds; Ethers, Cyclic; Female; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Polystyrenes; Rats; Stomach Neoplasms; Styrene; Styrenes | 1984 |
Metabolic activation of styrene by erythrocytes detected as increased sister chromatid exchanges in cultured human lymphocytes.
Topics: Biotransformation; Crossing Over, Genetic; Cyclophosphamide; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Humans; Leukocyte Count; Lymphocytes; Sister Chromatid Exchange; Styrene; Styrenes | 1983 |
Bone marrow cell chromosomal aberrations and styrene biotransformation in mice given styrene on a repeated oral schedule.
Topics: Administration, Oral; Animals; Biotransformation; Bone Marrow; Chromosome Aberrations; Epoxy Compounds; Kinetics; Male; Mice; Styrene; Styrenes | 1983 |
Ferrodoxin reductase catalyzes styrene oxidation to styrene oxide.
Topics: Epoxy Compounds; Ferredoxin-NADP Reductase; Kinetics; NADH, NADPH Oxidoreductases; Styrene; Styrenes; Superoxide Dismutase; Xanthine Oxidase | 1982 |
Investigation of styrene in the liver perfusion/cell culture system. No indication of styrene-7,8-oxide as the principal mutagenic metabolite produced by the intact rat liver.
Topics: Animals; Blood Proteins; Cells, Cultured; Cricetinae; Cricetulus; Epoxy Compounds; Ethers, Cyclic; In Vitro Techniques; Lactates; Lactic Acid; Liver; Liver Function Tests; Male; Microsomes, Liver; Mutagens; Rats; Rats, Inbred Strains; Styrene; Styrenes; Subcellular Fractions; Thioguanine | 1982 |
Studies on metabolism and toxicity of styrene. V. The metabolism of styrene, racemic, (R)-(+)-, and (S)-(--)-phenyloxiranes in the rat.
Topics: Acetylcysteine; Animals; Epoxy Compounds; Ethers, Cyclic; Hydrolysis; Rats; Rats, Inbred Strains; Stereoisomerism; Styrene; Styrenes | 1982 |
Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes.
Topics: Animals; Epoxy Compounds; Ethylene Glycols; In Vitro Techniques; Microsomes, Liver; Rats; Stereoisomerism; Styrene; Styrenes | 1981 |
Styrene oxidation to styrene oxide in human blood erythrocytes and lymphocytes.
Topics: Epoxy Compounds; Erythrocytes; Ethers, Cyclic; Humans; In Vitro Techniques; Kinetics; Lymphocytes; Oxidation-Reduction; Oxyhemoglobins; Styrene; Styrenes | 1981 |
Interactions of styrene and styrene oxide with partially purified cytochrome P-450 and P-448 from rat liver microsomes.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Epoxy Compounds; Ethers, Cyclic; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phosphatidylcholines; Protein Binding; Rats; Rats, Inbred Strains; Styrene; Styrenes | 1981 |
Stereoselective oxidation of styrene to styrene oxide in rats as measured by mercapturic acid excretion.
Topics: Acetylcysteine; Animals; Epoxy Compounds; Ethers, Cyclic; Female; Glutathione Transferase; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains; Stereoisomerism; Styrene; Styrenes | 1981 |
Possible regulatory role for nonaromatic carbon sources in styrene degradation by Pseudomonas putida CA-3.
Topics: Aldehyde Oxidoreductases; Biodegradation, Environmental; Carbon; Citrates; Citric Acid; Environmental Pollutants; Epoxy Compounds; Escherichia coli Proteins; Glutamic Acid; Isomerases; Oxygen; Oxygenases; Phenylacetates; Pseudomonas putida; Styrene; Styrenes | 1995 |
Dosimetry of styrene 7,8-oxide in styrene- and styrene oxide-exposed mice and rats by quantification of haemoglobin adducts.
Topics: Animals; Blood Proteins; Dose-Response Relationship, Drug; Drug Stability; Epoxy Compounds; Female; Gas Chromatography-Mass Spectrometry; Hemoglobins; Male; Mice; Mice, Inbred Strains; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Styrene; Styrenes | 1995 |
Urinary mandelic acid and hemoglobin adducts in fiberglass-reinforced plastics workers exposed to styrene.
Topics: Adult; Air Pollutants, Occupational; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Glass; Hemoglobins; Humans; Industry; Male; Mandelic Acids; Middle Aged; Occupational Exposure; Sensitivity and Specificity; Styrene; Styrenes | 1994 |
Assessment of the neurotoxicity of styrene, styrene oxide, and styrene glycol in primary cultures of motor and sensory neurons.
Topics: Animals; Cells, Cultured; Epoxy Compounds; Ethylene Glycols; Ganglia, Spinal; Membrane Potentials; Mice; Motor Neurons; Neurons, Afferent; Styrene; Styrenes | 1995 |
Expoxidation of styrene and substituted styrenes by whole cells of Mycobacterium sp. M156.
Topics: Biotransformation; Chromatography, Gas; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Kinetics; Mycobacterium; Optical Rotation; Stereoisomerism; Styrene; Styrenes; Substrate Specificity | 1994 |
A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man.
Topics: Administration, Inhalation; Administration, Oral; Animals; Epoxy Compounds; Glutathione; Humans; Hydrolysis; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Mice; Models, Biological; Pulmonary Alveoli; Rats; Solubility; Species Specificity; Styrene; Styrenes; Thermodynamics | 1994 |
32P-post-labeling detection of DNA adducts in mononuclear cells of workers occupationally exposed to styrene.
Topics: DNA; Epoxy Compounds; Female; Humans; Leukocytes, Mononuclear; Male; Occupational Exposure; Phosphorus Radioisotopes; Sister Chromatid Exchange; Styrene; Styrenes | 1994 |
Effects of styrene oxide on differentiation and viability of rodent embryo cultures.
Topics: Animals; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Epoxy Compounds; Lethal Dose 50; Rats; Rats, Sprague-Dawley; Styrene; Styrenes | 1994 |
Dose-dependent genotoxic effects of styrene on human blood lymphocytes and the relationship to its oxidative and metabolic effects.
Topics: Biotransformation; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Epoxy Compounds; Ethylene Glycols; Glutathione; Humans; Lymphocytes; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange; Styrene; Styrenes | 1993 |
In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human.
Topics: Administration, Inhalation; Animals; Epoxide Hydrolases; Epoxy Compounds; Glutathione Transferase; Humans; Indicators and Reagents; Liver; Lung; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Species Specificity; Styrene; Styrenes | 1993 |
Effects of indomethacin and arachidonic acid on sister chromatid exchange induction by styrene and styrene-7,8-oxide.
Topics: Adult; Analysis of Variance; Antimutagenic Agents; Arachidonic Acid; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Epoxy Compounds; Glutathione; Humans; Indomethacin; Lymphocytes; Male; Mutagens; Oxidation-Reduction; Sister Chromatid Exchange; Styrene; Styrenes | 1995 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Epoxy Compounds; gamma-Glutamyltransferase; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Lung Diseases; Male; Methionine Sulfoximine; Mice; Phenobarbital; Pyridines; Styrene; Styrenes; Trichloroepoxypropane | 1996 |
Determination of albumin and hemoglobin adducts in workers exposed to styrene and styrene oxide.
Topics: Air Pollutants, Occupational; Benzyl Alcohols; Carboxylic Acids; Carcinogens; Cohort Studies; Cysteine; Diet; DNA Adducts; Environmental Pollutants; Epoxy Compounds; Ethylene Glycols; Female; Follow-Up Studies; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Hydrolysis; Male; Occupational Exposure; Phenylethyl Alcohol; Plastics; Serum Albumin; Ships; Styrene; Styrenes | 1996 |
The effect of nutrient limitation on styrene metabolism in Pseudomonas putida CA-3.
Topics: Aldehyde Oxidoreductases; Biodegradation, Environmental; Epoxy Compounds; Escherichia coli Proteins; Glutamic Acid; Isomerases; Oxidation-Reduction; Oxygen Consumption; Phenylacetates; Pseudomonas putida; Styrene; Styrenes; Succinates; Succinic Acid | 1996 |
An investigation of multiple biomarkers among workers exposed to styrene and styrene-7,8-oxide.
Topics: Adult; Air Pollutants, Occupational; Biomarkers; Biotransformation; Carcinogenicity Tests; Carcinogens, Environmental; Cohort Studies; DNA; DNA Adducts; Epoxy Compounds; Female; Humans; Industry; Linear Models; Male; Microsomes, Liver; Occupational Exposure; Serum Albumin; Sister Chromatid Exchange; Smoking; Styrene; Styrenes | 1996 |
Excretion of N-acetyl-S-(1-phenyl-2-hydroxyethyl)-cysteine and N-acetyl-S-(2-phenyl-2-hydroxyethyl)-cysteine in workers exposed to styrene.
Topics: Acetylcysteine; Animals; Binding Sites; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cysteine; Environmental Monitoring; Epoxy Compounds; Glutathione; Glyoxylates; Humans; Male; Mandelic Acids; Mercaptoethanol; o-Phthalaldehyde; Occupational Exposure; Rats; Reference Standards; Spectrometry, Fluorescence; Stereoisomerism; Styrene; Styrenes; Ultrafiltration | 1997 |
Genotoxicity and cytotoxicity in male B6C3F1 mice following exposure to mixtures of 1,3-butadiene and styrene.
Topics: Animals; Bone Marrow; Butadienes; Carcinogens; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; Erythrocytes; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Spleen; Styrene; Styrenes; Thymus Gland; Toxicity Tests | 1997 |
Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice.
Topics: Animals; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Induction; Enzyme Inhibitors; Epoxy Compounds; Injections, Intraperitoneal; Lung; Male; Mice; Microsomes; Microsomes, Liver; Phenobarbital; Pyridines; Species Specificity; Styrene; Styrenes | 1997 |
Comparison of styrene-7,8-oxide adducts formed via reaction with cysteine, N-terminal valine and carboxylic acid residues in human, mouse and rat hemoglobin.
Topics: Animals; Binding Sites; Biotransformation; Carboxylic Acids; Cysteine; Epoxy Compounds; Hemoglobins; Humans; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Species Specificity; Styrene; Styrenes; Substrate Specificity; Valine | 1997 |
Ring test for the determination of N-terminal valine adducts of styrene 7,8-oxide with haemoglobin by the modified Edman degradation technique.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Styrene; Styrenes; Valine | 1997 |
Stereochemical aspects of styrene biotransformation.
Topics: Acetylcysteine; Animals; Biotransformation; Epoxy Compounds; Female; Magnetic Resonance Spectroscopy; Male; Mandelic Acids; Mutagens; Rats; Rats, Wistar; Stereoisomerism; Styrene; Styrenes | 1998 |
Towards a biocatalyst for (S)-styrene oxide production: characterization of the styrene degradation pathway of Pseudomonas sp. strain VLB120.
Topics: Base Sequence; Biodegradation, Environmental; Biotechnology; Catalysis; Cloning, Molecular; DNA Primers; Epoxy Compounds; Escherichia coli; Genes, Bacterial; Genes, Regulator; Isomerases; Kinetics; Molecular Sequence Data; Nucleic Acid Conformation; Oxygenases; Pseudomonas; Recombination, Genetic; RNA, Messenger; Sequence Deletion; Stereoisomerism; Styrene; Styrenes | 1998 |
Detection of styrene and styrene oxide-induced DNA damage in various organs of mice using the comet assay.
Topics: Animals; Bone Marrow; Cyclophosphamide; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Epoxy Compounds; Female; Injections, Intraperitoneal; Kidney; Liver; Lymphocytes; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Mutagens; Styrene | 1998 |
Styrene and styrene oxide affect the transport of dopamine in purified rat striatal synaptic vesicles.
Topics: Animals; Biological Transport; Dopamine; Epoxy Compounds; Humans; Mutagens; Rats; Styrene; Synapses; Synaptic Vesicles; Visual Cortex | 1999 |
An investigation of factors contributing to styrene and styrene-7,8-oxide exposures in the reinforced-plastics industry.
Topics: Carcinogens; Environmental Monitoring; Epoxy Compounds; Finland; Humans; Industry; Linear Models; Mutagens; Occupational Exposure; Occupations; Plastics; Resins, Plant; Risk Factors; Styrene | 1999 |
Influence of the R(61,2)- and S(61,2)-alpha-(N6-adenyl)styrene oxide adducts on the A.C mismatched base pair in an oligodeoxynucleotide containing the human N-ras codon 61.
Topics: Adenine; Base Pair Mismatch; Codon; Cytosine; DNA Adducts; Epoxy Compounds; Genes, ras; Humans; Hydrogen-Ion Concentration; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Oligodeoxyribonucleotides; Protons; Stereoisomerism; Styrene; Thermodynamics | 1999 |
Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene.
Topics: Air Pollutants; Benzene; Biomarkers; Carcinogens; Cyclohexanes; Cysteine; Environmental Monitoring; Epoxy Compounds; Hemoglobins; Humans; Kinetics; Linear Models; Occupational Exposure; Protein Binding; Serum Albumin; Solvents; Styrene | 1999 |
Metabolism of styrene by mouse and rat isolated lung cells.
Topics: Animals; Cell Separation; Cells, Cultured; Cytochrome P-450 Enzyme System; Epoxy Compounds; Isoenzymes; Lung; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Stereoisomerism; Styrene; Substrate Specificity | 1999 |
Biotransformation of styrene in mice. Stereochemical aspects.
Topics: Acetylcysteine; Animals; Biotransformation; Carbon Isotopes; Carcinogens; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Male; Mandelic Acids; Mice; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Styrene | 2000 |
Metabolism of styrene by human liver and lung.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzene; Carcinogens; Chromatography, High Pressure Liquid; Epoxy Compounds; Female; Humans; Lung; Male; Mice; Microsomes, Liver; Middle Aged; Phenol; Styrene | 2000 |
Styrene oxide in blood, hemoglobin adducts, and urinary metabolites in human volunteers exposed to (13)C(8)-styrene vapors.
Topics: Carbon Isotopes; Chromatography, High Pressure Liquid; Epoxy Compounds; Glyoxylates; Hemoglobins; Hippurates; Humans; Magnetic Resonance Spectroscopy; Male; Mandelic Acids; Styrene; Volatilization | 2000 |
A new method for the analysis of styrene mercapturic acids by liquid chromatography/electrospray tandem mass spectrometry.
Topics: Acetylcysteine; Chromatography, Liquid; Environmental Pollutants; Epoxy Compounds; Glutathione; Glyoxylates; Humans; Mandelic Acids; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Styrene | 2000 |
Biotransformations catalyzed by cloned p-cymene monooxygenase from Pseudomonas putida F1.
Topics: Bacterial Proteins; Benzyl Alcohol; Biotransformation; Cloning, Molecular; Epoxy Compounds; Escherichia coli; Gas Chromatography-Mass Spectrometry; Oxidoreductases; Pseudomonas putida; Styrene; Substrate Specificity; Toluene | 2001 |
Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometry.
Topics: Air; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity; Styrene | 2001 |
The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans.
Topics: Alkynes; Animals; Benzene Derivatives; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Glutathione Transferase; Humans; Male; Mice; Microsomes; Mutagens; Nasal Mucosa; Rats; Rats, Sprague-Dawley; Styrene | 2001 |
DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation.
Topics: Administration, Inhalation; Animals; Bone Marrow Cells; Comet Assay; DNA; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Erythrocytes; Hepatocytes; Lung; Lymphocytes; Male; Mice; Micronuclei, Chromosome-Defective; Mutagens; Styrene | 2001 |
Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids.
Topics: Acetylcysteine; Adult; Biomarkers; Carcinogens; Catalysis; Chromatography, High Pressure Liquid; Epoxide Hydrolases; Epoxy Compounds; Female; Free Radical Scavengers; Glutathione Transferase; Humans; Isoenzymes; Male; Mass Spectrometry; Occupational Exposure; Polymorphism, Genetic; Styrene; Xenobiotics | 2001 |
Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humans.
Topics: Air Pollutants, Occupational; Air Pollution, Indoor; Epoxide Hydrolases; Epoxy Compounds; Humans; Inhalation Exposure; Liver; Models, Biological; Occupational Exposure; Plastics; Styrene | 2001 |
Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air.
Topics: Adult; Air Pollutants; Animals; Dose-Response Relationship, Drug; Epoxy Compounds; Food Contamination; Humans; Lung Neoplasms; Male; Mice; Models, Biological; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Risk Assessment; Styrene | 2002 |
DNA adducts of styrene-7,8-oxide in target and non-target organs for tumor induction in rat and mouse after repeated inhalation exposure to styrene.
Topics: Administration, Inhalation; Animals; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Isomerism; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mutagens; Rats; Styrene | 2002 |
Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans.
Topics: Animals; Carcinogens; Epoxy Compounds; Forecasting; Humans; Inhalation Exposure; Liver; Mice; Models, Biological; Rats; Respiratory System; Styrene; Tissue Distribution | 2002 |
Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase.
Topics: Cell Line; Epoxy Compounds; Escherichia coli; Gene Expression Regulation, Bacterial; Oxygenases; Pilot Projects; Pseudomonas; Recombination, Genetic; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Styrene | 2002 |
Toxicity screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme films.
Topics: Biosensing Techniques; Camphor 5-Monooxygenase; DNA Adducts; DNA Damage; Electrochemistry; Epoxy Compounds; Hydrogen Peroxide; Kinetics; Mutagenicity Tests; Myoglobin; Styrene | 2003 |
A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung.
Topics: Administration, Inhalation; Animals; Carcinogens; DNA Adducts; Epoxy Compounds; Hemoglobins; Humans; Lung; Mice; Models, Biological; Rats; Species Specificity; Styrene | 2003 |
In vitro metabolism of styrene to styrene oxide in liver and lung of Cyp2E1 knockout mice.
Topics: Animals; Cytochrome P-450 CYP2E1; Environmental Pollutants; Epoxy Compounds; Liver; Lung; Male; Mice; Mice, Knockout; Styrene | 2003 |
Refinements to physiologically-based pharmacokinetic model for styrene.
Topics: Animals; Data Interpretation, Statistical; Epoxy Compounds; Humans; Lung; Mice; Models, Biological; Occupational Exposure; Rats; Styrene | 2003 |
Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide.
Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Cytochrome P-450 CYP2E1; Epoxy Compounds; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; Liver; Lung; Mice; Mice, Inbred Strains; Mice, Knockout; Styrene | 2004 |
Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase.
Topics: Cloning, Molecular; Dimerization; Electron Transport; Epoxy Compounds; Escherichia coli; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; FMN Reductase; Molecular Weight; NAD; Oxygenases; Protein Subunits; Pseudomonas; Recombinant Proteins; Riboflavin; Styrene; Substrate Specificity | 2004 |
Comparison of the depletion of glutathione in mouse liver and lung following administration of styrene and its metabolites styrene oxide and 4-vinylphenol.
Topics: Animals; Dose-Response Relationship, Drug; Epoxy Compounds; Glutathione; Liver; Lung; Male; Mice; Mice, Inbred ICR; Phenols; Styrene | 2005 |
Multistate reactivity in styrene epoxidation by compound I of cytochrome p450: mechanisms of products and side products formation.
Topics: Cytochrome P-450 Enzyme System; Epoxy Compounds; Models, Molecular; Oxidation-Reduction; Porphyrins; Quantum Theory; Styrene | 2005 |
Effects of styrene and its metabolites on different lung compartments of the mouse--cell proliferation and histomorphology.
Topics: Acetaldehyde; Animals; Apoptosis; Benzyl Alcohols; Bronchi; Cell Proliferation; Epoxy Compounds; Female; Glutathione; Humans; Injections, Intraperitoneal; Male; Mice; Phenols; Phenylacetates; Phenylethyl Alcohol; Styrene | 2005 |
Styrene-7,8-oxide burden in ventilated, perfused lungs of mice and rats exposed to vaporous styrene.
Topics: Administration, Inhalation; Air Pollutants, Occupational; Animals; Dose-Response Relationship, Drug; Drug Residues; Epoxy Compounds; Gases; In Vitro Techniques; Inhalation Exposure; Lung; Male; Mice; Mice, Inbred Strains; Perfusion; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Styrene | 2006 |
Styrene monomer primarily induces CYP2B1 mRNA in rat liver.
Topics: Animals; Biotransformation; Blotting, Western; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Epoxy Compounds; Inactivation, Metabolic; Liver; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Styrene | 2005 |
Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry.
Topics: Adolescent; Adult; Air Pollutants, Occupational; Air Pollution, Indoor; Biomarkers; Carcinogens; Environmental Monitoring; Epoxy Compounds; Female; Glass; Humans; Industry; Male; Middle Aged; Multivariate Analysis; Occupational Exposure; Plastics; Predictive Value of Tests; Styrene | 2006 |
The efficiency of recombinant Escherichia coli as biocatalyst for stereospecific epoxidation.
Topics: Biotransformation; Catalysis; Cell Membrane Permeability; Epoxy Compounds; Escherichia coli; Genetic Vectors; Kinetics; Oxygenases; Styrene | 2006 |
Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells.
Topics: Acetylcysteine; Animals; Animals, Genetically Modified; Biotransformation; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Glutathione; Humans; Styrene; Styrenes | 2006 |
Comparison of styrene and its metabolites styrene oxide and 4-vinylphenol on cytotoxicity and glutathione depletion in Clara cells of mice and rats.
Topics: Animals; Cell Survival; Cells, Cultured; Epoxy Compounds; Glutathione; Lung; Male; Mice; Mice, Inbred Strains; Phenols; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Styrene | 2006 |
Effects of styrene and styrene oxide on glutathione-related antioxidant enzymes.
Topics: Animals; Antioxidants; Dipeptides; Environmental Pollutants; Epoxy Compounds; Glutathione; Glutathione Reductase; Lipid Peroxidation; Lipid Peroxides; Liver; Lung; Mice; Mice, Inbred Strains; Styrene | 2006 |
Styrene-oxide N-terminal valine haemoglobin adducts in reinforced plastic workers: possible influence of genetic polymorphism of drug-metabolising enzymes.
Topics: Adult; Air Pollutants, Occupational; Biomarkers; Chemical Industry; Enzymes; Epoxy Compounds; Female; Glyoxylates; Hemoglobins; Humans; Inactivation, Metabolic; Male; Mandelic Acids; Occupational Exposure; Polymorphism, Genetic; Styrene; Valine; Workplace | 2007 |
Styrene-oxide N-terminal valine haemoglobin adducts as biomarkers of occupational exposure to styrene.
Topics: Adolescent; Adult; Air Pollutants, Occupational; Biomarkers; Case-Control Studies; Epoxy Compounds; Female; Hemoglobins; Humans; Male; Middle Aged; Occupational Exposure; Sensitivity and Specificity; Styrene; Valine | 2008 |
Microbial biofilms: new catalysts for maximizing productivity of long-term biotransformations.
Topics: Biofilms; Bioreactors; Biotechnology; Biotransformation; Catalysis; Epoxy Compounds; Pseudomonas; Styrene; Time Factors | 2007 |
An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling design.
Topics: Acetylcysteine; Adult; Air Pollutants, Occupational; Biomarkers; Biotransformation; Chemical Industry; Environmental Monitoring; Epoxy Compounds; Ethylene Glycols; Female; Glutathione Transferase; Hemoglobins; Humans; Male; Middle Aged; Occupational Exposure; Phenols; Polymorphism, Genetic; Serum Albumin; Smoking; Styrene | 2008 |
Investigation on the mechanisms of genotoxicity of butadiene, styrene and their combination in human lymphocytes using the Comet assay.
Topics: Adult; Butadienes; Cohort Studies; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Humans; In Vitro Techniques; Lymphocytes; Male; Mutagens; Occupational Exposure; Reactive Oxygen Species; Rubber; Styrene | 2009 |
Effect of multiple doses of styrene and R-styrene oxide on CC10, bax, and bcl-2 expression in isolated Clara cells of CD-1 mice.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Western; Epithelial Cells; Epoxy Compounds; Lung; Lung Neoplasms; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Styrene; Uteroglobin | 2009 |
Identification of a novel self-sufficient styrene monooxygenase from Rhodococcus opacus 1CP.
Topics: Bacterial Proteins; Chromatography, High Pressure Liquid; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Genome, Bacterial; Models, Biological; Molecular Sequence Data; Oxygenases; Phylogeny; Recombinant Proteins; Rhodococcus; Styrene | 2009 |
Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolites.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Carcinogens; Caspase 3; Caspase 8; Cells, Cultured; Deoxyguanosine; Epithelial Cells; Epoxy Compounds; Injections, Intraperitoneal; Lung; Male; Mice; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Messenger; Styrene; Superoxide Dismutase; Time Factors | 2009 |
Depletion by styrene of glutathione in plasma and bronchioalveolar lavage fluid of non-Swiss albino (NSA) mice.
Topics: Air Pollutants, Occupational; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Epoxy Compounds; Glutathione; Injections, Intraperitoneal; Lung; Male; Mice; Oxidative Stress; Styrene; Time Factors | 2010 |
Evidence for cellular protein covalent binding derived from styrene metabolite.
Topics: Animals; Cell Line; Cytochrome P-450 CYP2E1; Cytotoxins; Epoxy Compounds; Humans; Male; Mice; Protein Binding; Proteins; Styrene | 2010 |
Low temperature photo-oxidation of chloroperoxidase Compound II.
Topics: Chloride Peroxidase; Cold Temperature; Electron Spin Resonance Spectroscopy; Epoxy Compounds; Heme; Hydrogen-Ion Concentration; Iron; Kinetics; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Photochemical Processes; Photolysis; Reactive Oxygen Species; Solvents; Spectrophotometry, Ultraviolet; Styrene; Temperature | 2010 |
Metabolism and toxicity of styrene in microsomal epoxide hydrolase-deficient mice.
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Epoxide Hydrolases; Epoxy Compounds; Glutathione; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Microsomes; Styrene; Time Factors | 2010 |
Hepatotoxicity and pneumotoxicity of styrene and its metabolites in glutathione S-transferase-deficient mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Data Interpretation, Statistical; Epoxy Compounds; Glutathione; Glutathione Transferase; Inactivation, Metabolic; Liver; Lung; Mice; Mice, Knockout; Oxidative Stress; Phenols; Styrene | 2011 |
CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Epoxy Compounds; Female; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Styrene | 2012 |
Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytochrome P-450 Enzyme System; Epoxy Compounds; Glutathione; L-Iditol 2-Dehydrogenase; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH-Ferrihemoprotein Reductase; Styrene | 2012 |
Simultaneous determination of aromatic acid metabolites of styrene and styrene-oxide in rat urine by gas chromatography-flame ionization detection.
Topics: Acids, Carbocyclic; Administration, Inhalation; Animals; Benzoic Acid; Epoxy Compounds; Flame Ionization; Glyoxylates; Hippurates; Inhalation Exposure; Limit of Detection; Male; Mandelic Acids; Phenylacetates; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reproducibility of Results; Styrene; Urinalysis | 2012 |
Genotoxicity of styrene-7,8-oxide and styrene in Fisher 344 rats: a 4-week inhalation study.
Topics: Administration, Inhalation; Animals; Atmosphere Exposure Chambers; Blood Cell Count; Comet Assay; DNA Breaks; DNA Glycosylases; Epoxy Compounds; Erythrocytes; Male; Micronucleus Tests; Mutagens; Rats; Rats, Inbred F344; Reticulocytes; Styrene | 2012 |
Production host selection for asymmetric styrene epoxidation: Escherichia coli vs. solvent-tolerant Pseudomonas.
Topics: Biocatalysis; Bioreactors; Biotransformation; Epoxy Compounds; Escherichia coli; Glucose; Isomerases; Oxygenases; Pseudomonas; Solvents; Styrene | 2012 |
Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Epoxy Compounds; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenols; Species Specificity; Styrene | 2013 |
Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Epoxy Compounds; Lung; Mice; Mice, Knockout; Microsomes; Microsomes, Liver; Molecular Structure; Phenols; Styrene | 2014 |
Segmented flow is controlling growth of catalytic biofilms in continuous multiphase microreactors.
Topics: Biofilms; Bioreactors; Culture Media; Epoxy Compounds; Pseudomonas; Rheology; Styrene | 2014 |
Engineering of Pseudomonas taiwanensis VLB120 for constitutive solvent tolerance and increased specific styrene epoxidation activity.
Topics: Bacterial Proteins; Biocatalysis; Drug Resistance, Bacterial; Epoxy Compounds; Gene Deletion; Genetic Engineering; Molecular Sequence Data; Pseudomonas; Solvents; Styrene | 2014 |
An evaluation of concentrations of styrene-7,8-oxide in rats and humans resulting from exposure to styrene or styrene-7,8-oxide and potential genotoxicity.
Topics: Administration, Inhalation; Adult; Animals; DNA Damage; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Humans; Male; Models, Molecular; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Risk Factors; Styrene; Toxicity Tests | 2016 |
[Optimization of primary hepatocytes model and study on the cytotoxicity of styrene and styrene oxide].
Topics: Alanine Transaminase; Albumins; Animals; Cell Culture Techniques; Cell Survival; Cells, Cultured; Epoxy Compounds; Hepatocytes; L-Lactate Dehydrogenase; Mice; Mice, Inbred BALB C; Styrene | 2016 |
Evidential Proximity, Independence, and the evaluation of carcinogenicity.
Topics: Biomedical Research; Carcinogenesis; Carcinogens; Causality; Epoxy Compounds; Humans; International Agencies; Knowledge; Neoplasms; Philosophy, Medical; Public Health; Styrene | 2019 |
Production of styrene oxide from styrene by a recombinant
Topics: Bacterial Outer Membrane Proteins; Biocatalysis; Carrier Proteins; Cyclohexanes; Epoxy Compounds; Escherichia coli; Escherichia coli Proteins; Hexanes; Lipoproteins; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Oxygenases; Plasmids; Pseudomonas putida; Signal Transduction; Solvents; Styrene | 2020 |
A Highly Efficient Heterogeneous Catalyst of Bimetal-Organic Frameworks for the Epoxidation of Olefin with H
Topics: Alkenes; Catalysis; Copper; Epoxy Compounds; Hydrogen Peroxide; Metal-Organic Frameworks; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Styrene; X-Ray Diffraction | 2020 |
Influence of LiTaO
Topics: Adsorption; Density Functional Theory; Oxygen; Quantum Theory; Styrene | 2022 |