strychnine and tryptamine

strychnine has been researched along with tryptamine* in 2 studies

Other Studies

2 other study(ies) available for strychnine and tryptamine

Article	Year
Sequential acid/base-catalyzed polycyclization of tryptamine derivatives. A rapid access to Büchi's ketone. Organic letters, 2005, Nov-10, Volume: 7, Issue:23 [reaction: see text] The development of an efficient and diastereoselective methodology that allows the rapid construction of the tetracyclic core of the Aspidosperma and Strychnos alkaloid families is described. Our approach relies upon two key steps: a sequential silica gel/potassium tert-butoxide polycyclization of a tryptamine precursor and a tandem oxidative decarboxylation/ring-closing reaction. The assembly of Büchi's ketone, a key intermediate in the synthesis of vindorosine, has been accomplished using this approach. Topics: Alkaloids; Aspidosperma; Catalysis; Cyclization; Ketones; Molecular Structure; Stereoisomerism; Strychnos; Tryptamines	2005
[Interaction of the anxiolytic agent buspirone with serotonin and other synaptic receptors in the human brain]. Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:1 Buspirone and Mj 138-05 (up to 0.1 mM) did not displace specifically bound (3H) tryptamine, (3H) strychnine, (3H) flunitrazepam and (3H) imipramine in human cortical and hippocampal membrane preparations. At the same time both compounds displayed similar to serotonin affinity (IC50 in the range of 2-6 microM) for (125I)-LSD specific binding sites in the human cortex and hippocamp. IC50 of serotonin and buspirone and Mj 138-05 for (3H) LSD (2 nM) specific binding sites in the hippocamp was determined as 0.14 microM, 2.3 microM and 6.1 microM, respectively; and for (3H) serotonin specific binding sites in the hippocamp as 0.005 microM, 3.8 microM and 21 microM, respectively. The affinity for human cortex (3H) LSD binding sites was 10-fold lower in case of serotonin and 4-fold lower in case of buspirone and Mj 138-05 than in the hippocamp. However, the affinity for (3H) serotonin binding sites in the cortex was the same as in the hippocamp in case of serotonin and 12-15-fold lower than in the hippocamp in case of buspirone and Mj 138-05. It is concluded that in human brain buspirone and Mj 138-05 interact with micromolar affinity with 5 HT2 and are capable of binding to a subpopulation of 5 HT1 receptors in the hippocamp. Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Binding Sites; Brain; Buspirone; Cerebral Cortex; Female; Flunitrazepam; Hippocampus; Humans; Imipramine; In Vitro Techniques; Male; Middle Aged; Pyrimidines; Receptors, Neurotransmitter; Receptors, Serotonin; Strychnine; Tryptamines	1988

Article

Year

Sequential acid/base-catalyzed polycyclization of tryptamine derivatives. A rapid access to Büchi's ketone.

Organic letters, 2005, Nov-10, Volume: 7, Issue:23

[reaction: see text] The development of an efficient and diastereoselective methodology that allows the rapid construction of the tetracyclic core of the Aspidosperma and Strychnos alkaloid families is described. Our approach relies upon two key steps: a sequential silica gel/potassium tert-butoxide polycyclization of a tryptamine precursor and a tandem oxidative decarboxylation/ring-closing reaction. The assembly of Büchi's ketone, a key intermediate in the synthesis of vindorosine, has been accomplished using this approach.

Topics: Alkaloids; Aspidosperma; Catalysis; Cyclization; Ketones; Molecular Structure; Stereoisomerism; Strychnos; Tryptamines

2005

[Interaction of the anxiolytic agent buspirone with serotonin and other synaptic receptors in the human brain].

Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:1

Buspirone and Mj 138-05 (up to 0.1 mM) did not displace specifically bound (3H) tryptamine, (3H) strychnine, (3H) flunitrazepam and (3H) imipramine in human cortical and hippocampal membrane preparations. At the same time both compounds displayed similar to serotonin affinity (IC50 in the range of 2-6 microM) for (125I)-LSD specific binding sites in the human cortex and hippocamp. IC50 of serotonin and buspirone and Mj 138-05 for (3H) LSD (2 nM) specific binding sites in the hippocamp was determined as 0.14 microM, 2.3 microM and 6.1 microM, respectively; and for (3H) serotonin specific binding sites in the hippocamp as 0.005 microM, 3.8 microM and 21 microM, respectively. The affinity for human cortex (3H) LSD binding sites was 10-fold lower in case of serotonin and 4-fold lower in case of buspirone and Mj 138-05 than in the hippocamp. However, the affinity for (3H) serotonin binding sites in the cortex was the same as in the hippocamp in case of serotonin and 12-15-fold lower than in the hippocamp in case of buspirone and Mj 138-05. It is concluded that in human brain buspirone and Mj 138-05 interact with micromolar affinity with 5 HT2 and are capable of binding to a subpopulation of 5 HT1 receptors in the hippocamp.

Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Binding Sites; Brain; Buspirone; Cerebral Cortex; Female; Flunitrazepam; Hippocampus; Humans; Imipramine; In Vitro Techniques; Male; Middle Aged; Pyrimidines; Receptors, Neurotransmitter; Receptors, Serotonin; Strychnine; Tryptamines

1988