strychnine has been researched along with harman* in 1 studies
1 other study(ies) available for strychnine and harman
Article | Year |
---|---|
Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo.
Harmane and other related beta-carbolines are putative endogenous ligands of the benzodiazepine receptor. Since the compounds are potent convulsants they may have agonist activities at the benzodiazepine receptor while the benzodiazepines may be antagonists. This hypothesis was proved by comparing the in vivo and in vitro antagonism of benzodiazepines by harmane and other beta-carbolines. Harmane is clearly a competitive inhibitor of benzodiazepine receptor binding in vitro. Moreover, harmane-induced convulsions can be inhibited reversibly by diazepam in a manner which is consistent with the assumption of competitive antagonism in vivo. For some beta-carboline derivatives a correlation was found between the affinity for the benzodiazepine receptor in vitro and the convulsive potency in vivo. Thus, the data reported suggest that harmane or other related beta-carbolines are putative endogenous agonists of the benzodiazepine receptor. This suggestion is further supported by the observation that diazepam is equally potent in inhibiting harmane- or picrotoxin-induced convulsions, indicating a convulsive mechanism within the GABA receptor-benzodiazepine receptor system. Topics: Alkaloids; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Carbolines; Female; gamma-Aminobutyric Acid; Glycine; Harmine; In Vitro Techniques; Indoles; Rats; Receptors, Cell Surface; Receptors, Drug; Seizures; Spinal Cord; Strychnine | 1981 |