struvite has been researched along with phosphocitrate* in 2 studies
2 other study(ies) available for struvite and phosphocitrate
| Article | Year |
|---|---|
Crystal growth and molecular modeling studies of inhibition of struvite by phosphocitrate.
The inhibition by phosphocitrate of struvite crystal formation and growth has been examined in the present study. Crystal growth in a gel matrix was controlled by phosphocitrate in a dose-dependent manner. The effects of inhibition were followed using scanning electron microscopy, optical microscopy, and single crystal X-ray analysis. The presence of phosphocitrate induced very strong, crystal face specific inhibition of struvite, leading to total cessation of crystal growth when sufficient concentration of the inhibitor was made available. Crystal growth studies and results from molecular modeling indicated strong affinity of phosphocitrate to (101) faces of struvite. This in turn led to an alteration in the expression of these faces and the development of a characteristic arrowhead struvite morphology. Similar changes were not observed in the presence of identical concentrations of citrate, acetohydroxamic acid, and N-sulfo-2 amino tricarballylate (an analog of phosphocitrate), emphasizing the unique interaction of phosphocitrate with the struvite crystal lattice. Topics: Citrates; Computer Simulation; Crystallography; Crystallography, X-Ray; Magnesium Compounds; Models, Molecular; Phosphates; Struvite | 1997 |
Reduction of infection stones in rats by combined antibiotic and phosphocitrate therapy.
The potential of phosphocitrate to inhibit infection stones in rats when combined with an antibiotic was studied. A significant reduction occurred in both the number and weight of recovered stones from rats receiving combined treatment with amoxycillin (50 mg./kg. body wt./day and phosphocitrate (112 mumol./kg. body wt./day) for four weeks. The inhibitory responses were attributed to the intact phosphocitrate molecule as administration of citrate in equimolar concentrations did not mimic the observed effects of phosphocitrate. In comparison with non-infected controls, antibiotic treatment alone failed to eliminate total stone growth. However, composition of the stone reverted from predominantly struvite to a mixture of struvite and newberyite as urinary parameters normalized. The studies highlight the usefulness of phosphocitrate to restrict magnesium salt deposition in vivo. Topics: Amoxicillin; Animals; Citrates; Drug Therapy, Combination; Magnesium; Magnesium Compounds; Male; Phosphates; Proteus Infections; Proteus mirabilis; Rats; Struvite; Urinary Bladder Calculi | 1988 |