strontium-radioisotopes and ferric-ferrocyanide

Topics: Adult; Alginates; Drug Therapy, Combination; Female; Ferrocyanides; Glucuronic Acid; Hexuronic Acids; Humans; Intestinal Absorption; Nuclear Fission; Pentetic Acid; Potassium Iodide; Strontium Radioisotopes

The effect of simultaneous oral administration of a mixture of calcium alginate, ferrihexacyanoferrate(II) and KI and of the chelating agent zinc diethylenetriaminepentaacetate (Zn-DTPA) on the retention of radioactive Sr, Cs, I and Ce was investigated in 7-week-old female rats. The respective antidotes were administered in food during the first three days of the experiment and the radionuclides were administered on the second day of the experiment. The radionuclide retention was determined in the whole body, carcass, gut, liver, kidneys and respective critical organs six days after oral administration of 85Sr, 137Cs, 131I and intraperitoneal administration of 141Ce and one day after oral administration of 141Ce. Simultaneous oral administration of the four therapeutic agents reduced the retention of radioactive Sr, Cs and I administered orally and Ce applied intraperitoneally. Zn-DTPA did not diminish efficacy of antidotes from the mixture nor did the mixture significantly alter the effect of Zn-DTPA. Simultaneous oral administration of calcium alginate, ferrihexacyanoferrate(II), KI and Zn-DTPA might present a convenient method for delayed therapy especially in cases of prolonged increased environmental exposure to several radionuclides.

Topics: Administration, Oral; Alginates; Animals; Antidotes; Cerium Radioisotopes; Cesium Radioisotopes; Decontamination; Female; Ferrocyanides; Glucuronic Acid; Hexuronic Acids; Iodine Radioisotopes; Pentetic Acid; Potassium Iodide; Radioisotopes; Rats; Strontium Radioisotopes

The mixture of radionuclides was employed in the concentrations of 100.0, 400.0 and 0.8, 2.0 mc/rat for strontium-90 and cesium-137 in single and chronic administration correspondingly. Prussian blue, sodium alginate and calcium were employed in amounts of 50 mg, 800 mg and 258 mg per rat a day. The data obtained are correlated with the results of the same experiments without using the protection. In compared doses of the irradiation the protective action of the substances under study was noted only in chronic experiments. In this case, the appearance of malignant neoplasms was nearly twice less, and the survival was 120 days longer. The absorbed doses were decreased by 17 times for cesium-137 in the whole body and nearly by 4 times for strontium-90 in the skeleton.

Topics: Alginates; Animals; Calcium Phosphates; Cesium Radioisotopes; Coloring Agents; Drug Evaluation; Environmental Exposure; Female; Ferric Compounds; Ferrocyanides; Neoplasms, Radiation-Induced; Radiation-Protective Agents; Rats; Sodium; Strontium Radioisotopes