strobilurin-b and butenolide

Two strobilurins, 9-methoxystrobilurin B (1) and 9-methoxystrobilurin G (2), two monochlorinated 2,3-dihydro-1-benzoxepin derivatives, 3 and 4a, and butenolide 5, together with four known compounds, strobilurin B, 9-methoxystrobilurin A, and oudemansins A and B, were isolated from culture BCC 18689 of the fungus Favolaschia tonkinensis. 9-Methoxystrobilurins A, B (1), and G (2) and oudemansins A and B exhibited antimalarial, antifungal, and cytotoxic activities, while compounds 3, 4a, and 5 displayed only cytotoxic activity.

Topics: 4-Butyrolactone; Animals; Antifungal Agents; Antimalarials; Basidiomycota; Benzoxepins; Candida albicans; Chlorocebus aethiops; Cytotoxins; Drug Screening Assays, Antitumor; Fatty Acids, Unsaturated; Female; Humans; KB Cells; Methacrylates; Microbial Sensitivity Tests; Molecular Structure; Plasmodium falciparum; Pyrazoles; Pyrimidines; Strobilurins; Thailand; Vero Cells