strictosamide and pumiloside

In order to study the chemical constituents in the water extract of the stem of Nauclea officinalis, column chromatography over D101 macroporous resin and silica gel and an automatic purification system were used to isolate and purify the chemical constituents from the extract. Nine compounds were obtained. By analysis of the physicochemical properties and spectral data, their structures were identified as naucleamide G (1), 3, 4-dimethoxyphenol-beta-D-apiofuranosyl (1-->6)-beta-D-glucopyranoside (2), kelampayoside A (3), 3alpha, 5alpha-tetrahydrodeoxycordifoline lactam (4), naucleamide A-10-O-beta-D-glucopyranoside (5), pumiloside (6), 3-epi-pumiloside (7), strictosamide (8) and vincosamide (9), separately. Among them, compound 1 is a new compound, compound 2 was found in plants of the genus Nauclea for the first time, and compounds 3 and 4 were isolated from this plant for the first time.

Topics: Camptothecin; Carbolines; Glucosides; Indole Alkaloids; Molecular Structure; Plant Stems; Plants, Medicinal; Rubiaceae; Vinca Alkaloids

To study the chemical constituents of the leaves of Naudea officinalis.. The chemical constituents were separated by column chromatography and semi-preparative HPLC techniques, and their structures were determined by spectral analysis.. Five compounds were isolated and identified as strictosamide (1), 10-hydroxy strictosamide (2), kaempferol-3-O-rutinoside (3), rutin (4), pumiloside(5).. Among these compounds, 2, 3, 4 are isolated from the leaves of Naudea officinalis for the first time.

Topics: Camptothecin; Chromatography, High Pressure Liquid; Kaempferols; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Leaves; Rutin; Vinca Alkaloids

To study chemical constituents of the leaves of Nauclea officinalis, eight alkaloids were isolated from 95% ethanol extract by various chromatographic methods. The structures were elucidated on the basis of spectroscopic data (IR, UV, ESI-MS, 1D and 2D NMR) and identified as naucleactonin C (1), strictosamide (2), vincosamide (3), pumiloside (4), angustoline (5), angustine (6), 18, 19-dihydroangustine (7) and naucleofficine D (8). Compound 1 is a new indole alkaloid. Compounds 6 and 7 were isolated from this plant for the first time.

Topics: Alkaloids; Camptothecin; Indole Alkaloids; Indoles; Molecular Structure; Plant Leaves; Plants, Medicinal; Rubiaceae; Vinca Alkaloids