sto-609 has been researched along with ecopipam* in 1 studies
1 other study(ies) available for sto-609 and ecopipam
| Article | Year |
|---|---|
Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons.
We reported recently that activators of AMP-activated protein kinase (AMPK) slow the rundown of current evoked by the D2 autoreceptor agonist quinpirole in rat substantia nigra compacta (SNC) dopamine neurons. The present study examined the effect of AMPK on current generated by dopamine, which unlike quinpirole, is a substrate for the dopamine transporter (DAT). Using whole-cell patch-clamp, we constructed current-voltage (I-V) plots while superfusing brain slices with dopamine (100 μM) for 25 min. Two minutes after starting superfusion, dopamine evoked a peak current with an average slope conductance of 0.97 nS and an estimated reversal potential (E Topics: AMP-Activated Protein Kinases; Animals; Benzamides; Benzazepines; Benzimidazoles; Biphenyl Compounds; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Naphthalimides; Pars Compacta; Patch-Clamp Techniques; Piperazines; Pyrazoles; Pyrimidines; Pyrones; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Sulpiride; Thiophenes | 2020 |