stilbenes and pinobanksin

stilbenes has been researched along with pinobanksin* in 1 studies

Other Studies

1 other study(ies) available for stilbenes and pinobanksin

Article	Year
Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa. Phytotherapy research : PTR, 2008, Volume: 22, Issue:7 Methanol extracts of wood from Pinus resinosa were found to be selectively cytotoxic against human lung carcinoma cells, A549 (IC50 41 +/- 6 microg/mL), human colorectal adenocarcinoma cells, DLD-1 (IC50 47 +/- 4 microg/mL) in comparison with healthy cells, WS1 (IC50 130 +/- 11 microg/mL). Five known compounds were isolated and identified by 1H, 13C NMRspectroscopy and HR-ESI-MS mass spectrometry as, pinosylvin monomethyl ether (1), pinosylvin (2), pinosylvin dimethyl ether (3), pinobanksin (4) and (-)-norachelogenin (5). Compound 4 was isolated for the first time in P. resinosa. The cytotoxicity of compounds 1-5 was evaluated against A549, DLD-1 and WS1. Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1. Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Flavanones; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methanol; Neoplasms; Pinus; Plant Extracts; Skin; Spectrometry, Mass, Electrospray Ionization; Stilbenes; Wood	2008

Article

Year

Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa.

Phytotherapy research : PTR, 2008, Volume: 22, Issue:7

Methanol extracts of wood from Pinus resinosa were found to be selectively cytotoxic against human lung carcinoma cells, A549 (IC50 41 +/- 6 microg/mL), human colorectal adenocarcinoma cells, DLD-1 (IC50 47 +/- 4 microg/mL) in comparison with healthy cells, WS1 (IC50 130 +/- 11 microg/mL). Five known compounds were isolated and identified by 1H, 13C NMRspectroscopy and HR-ESI-MS mass spectrometry as, pinosylvin monomethyl ether (1), pinosylvin (2), pinosylvin dimethyl ether (3), pinobanksin (4) and (-)-norachelogenin (5). Compound 4 was isolated for the first time in P. resinosa. The cytotoxicity of compounds 1-5 was evaluated against A549, DLD-1 and WS1. Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1.

Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Flavanones; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methanol; Neoplasms; Pinus; Plant Extracts; Skin; Spectrometry, Mass, Electrospray Ionization; Stilbenes; Wood

2008