stilbenes and crolibulin

A series of novel 4,6-diphenyl-2-(1H-pyrrol-1-yl)nicotinonitrile analogues of crolibulin and combretastatin A-4 (CA-4) were discovered using a 2-(1H-pyrrol-1-yl)pyridine ring as link-bridge to retain the cis-orientations of A-ring and B-ring. All the target compounds were synthesized and evaluated for their antiproliferative activity against five human cancer cell lines. Compounds 6a-d exhibited superior potency, with IC

Topics: Antineoplastic Agents; Benzopyrans; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Microtubules; Models, Molecular; Molecular Structure; Niacin; Nitriles; Stilbenes; Structure-Activity Relationship