stigmasterol and taraxerol

Hyperpigmentation is considered by many to be a beauty problem and is responsible for photoaging. To treat this skin condition, medicinal cosmetics containing tyrosinase inhibitors are used, resulting in skin whitening. In this study, taraxerol methyl ether (

Topics: Antioxidants; Arbutin; Cell Line, Tumor; Cell Proliferation; Flavonoids; Humans; Hydroxybenzoates; Manilkara; Monophenol Monooxygenase; Neoplasms; Oleanolic Acid; Phytochemicals; Pyrones; Stigmasterol

To investigate the chemical constituents of the leaves of Clerodendrum trichotomum.. The chemical constituents of petroleum ether extract of the leaves of Clerodendrum trichotomum were isolated and purified by various chromatographic techniques, such as silica gel, ODS, Sephadex LH-20, semi-preparative HPLC and recrystallization. The structures of these isolated compounds were identified by spectroscopic analysis (1 H-NMR,13 C-NMR,2D-NMR and MS).. Ten compounds were isolated and identified from petroleum ether extract, containing four triterpenes, lupeol(1), friedelin(2), betulinic acid(3) and taraxerol(4); four sterols, 22-dehydroclerosterol(5), clerosterol(6), stigmasterol(7) and sitosterol(8); one diterpenoid, transphytol(9), and one alkaloid, 1H-indole-3-carboxylic acid(10).. Compound 10 is obtained from the genus Clerodendrum for the first time, and seven compounds (1,3-4, and 7-10) are firstly isolated from this plant.

Topics: Betulinic Acid; Clerodendrum; Indoles; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Sitosterols; Sterols; Stigmasterol; Triterpenes

Bioassay-guided fractionation of the N-hexane and CHCl₃ phases of the methanol extract of the roots of Conyza canadensis (L.) Cronquist led to the isolation of two new dihydropyranones named conyzapyranone A (1) and B (2), and the known 4 Z,8 Z-matricaria- γ-lactone (3), 4 E,8 Z-matricaria- γ-lactone (4), 9,12,13-trihydroxy-10(E)-octadecenoic acid (5), epifriedelanol (6), friedeline (7), taraxerol (8), simiarenol (9), spinasterol (10), stigmasterol, β-sitosterol, and apigenin. The structures were determined by means of ESIMS and 1D and 2D NMR spectroscopy, including ¹H-¹H COSY, NOESY, HSQC, and HMBC experiments. The isolated compounds were evaluated for their antiproliferative activities and were demonstrated to exert considerable cell growth-inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431), and breast adenocarcinoma (MCF-7) cells. Some of the active components, including 2, 4, and 10, proved to be substantially more potent against these cell lines than against noncancerous human foetal fibroblasts (MRC-5) and can therefore be considered selective antiproliferative natural products.

Topics: Antineoplastic Agents, Phytogenic; Apigenin; Cell Line, Tumor; Chemical Fractionation; Chromatography, High Pressure Liquid; Conyza; Female; Humans; Hydroxy Acids; Magnetic Resonance Spectroscopy; Molecular Structure; Oils, Volatile; Oleanolic Acid; Oleic Acids; Plant Extracts; Plant Roots; Pyrones; Sitosterols; Stigmasterol

To study the chemical constituents of Uvaria microcarpa.. The constituents were repeatedly separated and purified with silica gel column and Sephadex LH-20 column, and identified by physico-chemical properties and spectral methods.. Nine compounds were separated and identified as beta-sitosterol palmitate (I), euphorginol (II), beta-sitosterol (III), benzoic acid(IV), stigmasterol-3-O-beta-D-glucopyranoside (V), taraxerol (VI), emodin (VII), aristololactam A II (VI), beta-daucosterol (IX) .. Compounds I, II, V, V are isolated from this plant for the first time.

Topics: Emodin; Glucosides; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Sitosterols; Spectrophotometry, Ultraviolet; Stigmasterol; Uvaria