stigmasterol and onychine

stigmasterol has been researched along with onychine* in 1 studies

Other Studies

1 other study(ies) available for stigmasterol and onychine

Article	Year
Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep. Molecules (Basel, Switzerland), 2009, Nov-03, Volume: 14, Issue:11 This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications. Topics: Alkaloids; Anti-Infective Agents; Antimalarials; Cell Line; Cell Line, Tumor; Cell Survival; Flavanones; Humans; Microbial Sensitivity Tests; Molecular Structure; Plant Extracts; Plasmodium falciparum; Polyalthia; Pyridones; Sitosterols; Stigmasterol; Triterpenes	2009

Article

Year

Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.

Molecules (Basel, Switzerland), 2009, Nov-03, Volume: 14, Issue:11

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

Topics: Alkaloids; Anti-Infective Agents; Antimalarials; Cell Line; Cell Line, Tumor; Cell Survival; Flavanones; Humans; Microbial Sensitivity Tests; Molecular Structure; Plant Extracts; Plasmodium falciparum; Polyalthia; Pyridones; Sitosterols; Stigmasterol; Triterpenes

2009