stigmasterol has been researched along with 1-hexacosanol* in 2 studies
2 other study(ies) available for stigmasterol and 1-hexacosanol
| Article | Year |
|---|---|
Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata.
Chromolaena odorata, has been traditionally known for its insect repellent property. Aim of this study was to determine larvicidal tendency of C. odorata on Culex quinquefasciatus and isolate compounds responsible for this activity and to determine the mechanism of action of these compounds.. C. odorata plant extract was screened for mosquito larvicidal activity. The extract was fractionated using chromatography and the bioactive fraction showing larvicidal activity was identified. The chemical nature of the compounds in the bioactive fraction was determined using NMR and Mass spectrometry.. We identified phytosterols and alkanols to be the compounds regulating larvicidal activity in the bioactive fraction of the plant extract. Stigmasterol and 1-hexacosanol were identified to be the chief orchestrators of larvicidal activity and their mode of action has been observed to be neurotoxicity. At a molecular level both stigmasterol and 1-hexacosanol were found to be inhibiting acetylcholinesterase activity in C. quinquefasciatus & A. aegypti. The acetylcholinesterase inhibitory effect was validated in vitro using recombinant acetylcholinesterase and ex vivo in larval homogenates of Culex and Aedes. Electrophysiological studies using electroantennography have shown enhanced neural response to these compounds.. Neurotoxic effect of C. odorata derived stigmasterol and 1-hexacosanol, exerted through acetylcholinesterase inhibition was responsible for the mortality of C. quinquefasciatus, A. aegypti &Chironomus riparius. EAG studies pointed out hyper-excitability of the olfactory system by these compounds.. These compounds are natural agents for mosquito control that can be used in vector control as larvicidal compounds, pending further investigations. Topics: Acetylcholinesterase; Aedes; Animals; Cholinesterase Inhibitors; Chromolaena; Fatty Alcohols; Insecticides; Larva; Neurotoxins; Phytosterols; Plant Extracts; Plant Leaves; Stigmasterol | 2017 |
[Studies on the diterpenoids of Wedelia prostrata].
To study the chemical constituents of Wedelia prostrata.. Chromatography and spectroscopic analysis were employed to isolate and elucidate the chemical constituents in the plant.. Seven compounds were obtained and identified as ent-kaur-16-en-19-oic acid (I), ent-kaur-16alpha, 17-dihydroxy-19-oic acid (II), ent-kaur-15alpha-senecioyloxy-16-en-19-oic acid (III), beta-sitosterol (IV), stigmasterol (V), stigmasterol-3-O-beta-D-glucopyranoside (VI) and n-hexacosanol (VII).. Compounds I-III are isolated from this plant for the first time. Topics: Diterpenes; Fatty Alcohols; Glucosides; Molecular Structure; Plant Components, Aerial; Sitosterols; Spectrophotometry, Ultraviolet; Stigmasterol; Wedelia | 2011 |