stepholidine and discretamine

To identify novel bioactive compounds, an image-based, cell culture screening of natural product extracts was conducted. Specifically, our screen was designed to identify phytochemicals that might phenocopy inhibition of the chromosomal passenger protein complex in eliciting mitotic and cytokinetic defects. A known alkaloid, scoulerine, was identified from the rhizomes of the plant

Topics: Aurora Kinase A; Aurora Kinase B; Berberine Alkaloids; Cell Line; China; Corydalis; Cytokinesis; Enzyme Inhibitors; Humans; Mitosis; Molecular Structure; Phytochemicals; Rhizome