stearates has been researched along with calpastatin* in 1 studies
1 other study(ies) available for stearates and calpastatin
| Article | Year |
|---|---|
Calpain-calpastatin and fusion. Fusibility of erythrocytes is determined by a protease-protease inhibitor [calpain-calpastatin] balance.
Rat erythrocytes fuse when treated with the membrane mobility agent, 2-(2-methoxyethoxy)ethyl-cis-8-(2-octylcyclopropyl)octanoate (A2C) and Ca2+, whereas human cells do not. Membrane proteolysis promoted by calpain is required for rat cell fusion [(1986) Eur. J. Biochem., in press]. Human calpain induced a selective proteolysis in both the human and rat erythrocyte ghosts (mainly band 4.1 in the human, band 4.1 and band 3 in the rat cell) and rendered them fusible. Calpastatin (calpain inhibitor) prevented A2C-induced fusion in both ghosts, via inhibition of proteolysis. The human erythrocyte has excess calpastatin and resists A2C-promoted fusion. A regulatory role of calpastatin in membrane fusion is thus indicated. Topics: Animals; Calcium; Calcium-Binding Proteins; Calpain; Cell Fusion; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Protease Inhibitors; Rats; Species Specificity; Stearates | 1986 |