staurosporine and wortmannin

Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Animals; Binding Sites; Brain; Cattle; Chromones; Crystallography, X-Ray; Enzyme Inhibitors; Flavonoids; Humans; Models, Molecular; Molecular Sequence Data; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Conformation; Protein Structure, Secondary; Quercetin; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Wortmannin

Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Binding Sites; Cell Cycle Proteins; Humans; Models, Molecular; Molecular Sequence Data; Peptide Library; Polo-Like Kinase 1; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Substrate Specificity; Wortmannin

Topics: Antineoplastic Agents, Phytogenic; Australia; Cell Line, Tumor; Crystallography, X-Ray; Cyclobutanes; Guaiacol; Humans; Inhibitory Concentration 50; Lauraceae; Lignans; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan

Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin

Topics: Alkaloids; Androstadienes; Blood Platelets; Blood Proteins; Calcium; Collagen; Humans; Ionomycin; Phosphates; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Alkaloids; Androstadienes; Animals; Carbamates; Dose-Response Relationship, Drug; Eicosanoids; Endotoxins; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Phenylcarbamates; Phospholipase D; Protein Kinase C; Pulmonary Edema; Rats; Rats, Inbred Strains; Salmonella enteritidis; Staurosporine; Type C Phospholipases; Vasoconstriction; Wortmannin

Topics: Alkaloids; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Basophils; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Staurosporine; Wortmannin

Topics: Alkaloids; Androstadienes; Antibodies, Anti-Idiotypic; Basophils; Cells, Cultured; Histamine Release; Humans; Immunoglobulin E; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Alkaloids; Androstadienes; Animals; Carbazoles; Genistein; Hematopoietic Cell Growth Factors; Histamine Release; In Vitro Techniques; Indoles; Isoflavones; Mast Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Stem Cell Factor; Wortmannin

Topics: Alkaloids; Androstadienes; Antigens, CD; CD18 Antigens; Genistein; Integrins; Isoflavones; Lymphocyte Function-Associated Antigen-1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella; Wortmannin

Topics: Alkaloids; Androstadienes; Animals; Calcium; Cerebral Arteries; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Naphthalenes; Potassium Chloride; Protein Kinase C; Rabbits; Staurosporine; Vasoconstriction; Wortmannin

Topics: Alkaloids; Androstadienes; Basophils; Biomarkers, Tumor; Carbazoles; Chemokine CCL2; Genistein; Histamine Release; Humans; Indoles; Isoflavones; Lymphokines; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Protein, Translationally-Controlled 1; Wortmannin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Arachidonic Acid; Blood Platelets; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lysophospholipids; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Wortmannin

Topics: Androstadienes; Caco-2 Cells; Campylobacter jejuni; Cell Membrane; Chelating Agents; Cholera Toxin; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Filipin; Humans; Intestines; Signal Transduction; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Eukaryotic Initiation Factor-4E; Immunophilins; Intracellular Signaling Peptides and Proteins; Nerve Growth Factors; PC12 Cells; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Wortmannin

Topics: Androstadienes; Calcium; Cell Communication; Cell-Free System; Dose-Response Relationship, Drug; Humans; Neutrophils; Staurosporine; Superoxides; Tretinoin; Wortmannin

Topics: Analgesics; Androstadienes; Animals; Apoptosis; Benzeneacetamides; Cell Line, Transformed; Cell Survival; Ceramides; Chromones; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression; Mice; Morpholines; Narcotics; Neuroblastoma; Neurons; Pyrrolidines; Receptors, Opioid, kappa; Staurosporine; Time Factors; Wortmannin

Topics: Adipose Tissue; Affinity Labels; Androstadienes; Animals; Azides; Biological Transport; Blood Platelets; Cell Compartmentation; Cell Membrane; Cytochalasin B; Deoxyglucose; Disaccharides; Epididymis; Glucose; Glucose Transporter Type 3; Glycosides; Humans; Insulin; Male; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Propylamines; Rats; Staurosporine; Thrombin; Wortmannin

Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-5; Janus Kinase 2; Nitriles; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; Staurosporine; Tyrphostins; Wortmannin

Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phosphorylation; Polyenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Sirolimus; Staurosporine; Wortmannin

Topics: Amino Acid Sequence; Androstadienes; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Genistein; Humans; Molecular Sequence Data; Peptide Fragments; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Apoptosis; Benzeneacetamides; Cell Line; Cell Survival; Chick Embryo; Cyclic AMP; Endorphins; Enzyme Inhibitors; Mice; Narcotics; Neurons; Pyrrolidines; Receptors, Opioid, kappa; Staurosporine; Wortmannin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Aorta; Azepines; Blotting, Western; Cell Line; Dinoprost; Enzyme Inhibitors; Kinetics; Mice; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Staurosporine; Wortmannin

Topics: Androstadienes; Antigens, CD; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Membrane Permeability; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Histocytochemistry; Humans; Indoles; Lymphokines; Membrane Proteins; Muscle, Smooth, Vascular; Nitriles; Occludin; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Serum Albumin; Staurosporine; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

Topics: Androstadienes; B-Lymphocytes; Captopril; Cell Movement; Collagenases; Concanavalin A; Cytokines; Gene Expression Regulation, Enzymologic; Growth Substances; Herpesvirus 4, Human; Humans; Lipopolysaccharides; Matrix Metalloproteinase 9; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Transformation, Genetic; Transforming Growth Factor beta; Wortmannin

Topics: Androstadienes; Animals; Benzoquinones; Cell Size; Collagen; Cytoskeleton; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Humans; Lactams, Macrocyclic; Liver; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Signal Transduction; Staurosporine; Talin; Tumor Cells, Cultured; Vinculin; Vitamin A; Wortmannin

Topics: Adhesins, Bacterial; Androstadienes; Bacterial Adhesion; Bacterial Outer Membrane Proteins; Bacterial Proteins; Caco-2 Cells; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genistein; HeLa Cells; Humans; Interleukin-8; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Staurosporine; Transcriptional Activation; Tumor Cells, Cultured; Wortmannin; Yersinia enterocolitica

Topics: Androstadienes; Animals; Antibodies, Monoclonal; Antigens, CD; Benzoquinones; Cells, Cultured; Collagen; Collagenases; Diterpenes; Drug Combinations; Enzyme Inhibitors; Gels; Humans; Integrin alpha2; Lactams, Macrocyclic; Laminin; Lipid Metabolism; Liver; Liver Neoplasms; Male; Matrix Metalloproteinase 1; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteoglycans; Quinones; Rats; Rats, Wistar; Retinyl Esters; Rifabutin; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Vitamin A; Wortmannin

Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin

Topics: Alkaloids; Androstadienes; Antigens, Nuclear; Ataxia Telangiectasia; Camptothecin; Cell Cycle; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Humans; Ku Autoantigen; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Replication Protein A; Staurosporine; Tumor Cells, Cultured; Wortmannin

Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin

Topics: Androstadienes; Apoptosis; Carcinoma; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Antisense; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; Staurosporine; Transfection; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genes, jun; Histamine; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Histamine H2; Recombinant Proteins; RNA, Messenger; Sirolimus; Staurosporine; Transfection; Wortmannin

Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin

Topics: Adult; Alkaloids; Androstadienes; Animals; Azepines; Calcimycin; Calcium; Carbazoles; Carrier Proteins; Cell Size; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Humans; Indoles; K Cl- Cotransporters; Magnesium; Myosin-Light-Chain Kinase; Naphthalenes; Sheep; Staurosporine; Symporters; Wortmannin

Topics: Androstadienes; Apoptosis; Bacterial Proteins; Bacterial Toxins; bcl-X Protein; Biomarkers; Cell Differentiation; Cell Size; DNA Fragmentation; Gene Expression Regulation; Humans; Microtubule-Associated Proteins; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphopyruvate Hydratase; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; rhoA GTP-Binding Protein; Signal Transduction; Staurosporine; Synaptophysin; Tetradecanoylphorbol Acetate; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Animals; Cells, Cultured; Cytochrome P-450 CYP2E1; Drug Interactions; Enzyme Inhibitors; Gene Expression; Hepatocytes; Insulin; Insulin Antagonists; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quercetin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serum Albumin; Staurosporine; Transcription Factor AP-1; Wortmannin

Topics: Actins; Androstadienes; Biopolymers; Cell Line; Chemokine CCL2; Chemotaxis; Cytochalasin B; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Humans; Macromolecular Substances; Monocytes; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Protein Binding; Protein Kinase C; Pyrrolidinones; Receptors, CCR2; Receptors, Chemokine; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Staurosporine; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin

Topics: Aldehydes; Amyloid beta-Protein Precursor; Androstadienes; Blood Platelets; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Humans; Hydrogen Peroxide; In Vitro Techniques; Phospholipases A; Pyrrolidinones; Sodium Azide; Staurosporine; Thrombin; Type C Phospholipases; Wortmannin

Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; bcl-X Protein; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Etoposide; Immunoblotting; Mice; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors; Transfection; Wortmannin

Topics: Androstadienes; Animals; Blood Platelets; Cyclooxygenase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Indomethacin; Lipopolysaccharides; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proteus mirabilis; Signal Transduction; Staurosporine; Superoxides; Swine; Wortmannin

Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Calcium; Chromones; Enzyme Inhibitors; Leukemia, Basophilic, Acute; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Quercetin; Rats; Staurosporine; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Animals; Blood Proteins; Chromones; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Fibrinogen; Flow Cytometry; Kinetics; Membrane Proteins; Mice; Microscopy, Electron, Scanning; Morpholines; Myosin Light Chains; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Staurosporine; Time Factors; Wortmannin

Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin

Topics: Androstadienes; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase 9; Caspases; Cells, Cultured; Complement C5a; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin

Topics: Androstadienes; Asbestos, Amphibole; Cytochalasin B; Enzyme Inhibitors; Genistein; Humans; Luminescent Measurements; Neutrophils; Reactive Oxygen Species; Signal Transduction; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Apoptosis; bcl-Associated Death Protein; Blood Physiological Phenomena; Carrier Proteins; Enzyme Inhibitors; Mice; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Staurosporine; Subcellular Fractions; Transfection; Tumor Cells, Cultured; Wortmannin

Topics: Androstadienes; Animals; Calcium; Cells, Cultured; Chromones; COS Cells; Enzyme Inhibitors; Indoles; Inositol Phosphates; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Receptors, Transforming Growth Factor beta; Staurosporine; Transforming Growth Factor beta; Wortmannin

Topics: Acetylcholine; Androstadienes; Animals; Biological Transport; Blotting, Northern; Calmodulin; Cattle; Cholinergic Agonists; Chromaffin Cells; Down-Regulation; Enzyme Inhibitors; Genistein; Glucose; Mitogen-Activated Protein Kinases; Models, Biological; Mutagens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin

Topics: Androstadienes; Anilides; Animals; Annexin A5; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Chromones; Culture Media, Serum-Free; Flavonoids; Flow Cytometry; Humans; Imidazoline Receptors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Morpholines; Oligopeptides; PC12 Cells; Proteins; Rats; Staurosporine; Thapsigargin; Transfection; Wortmannin

Topics: 1-Butanol; Androstadienes; Aristolochic Acids; Cell Degranulation; Chromones; Cinnamates; Cytochalasin B; Cytoplasmic Granules; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Humans; Luminescent Measurements; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phosphatidic Acids; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Phospholipases A; Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Reactive Oxygen Species; Staurosporine; Sulfides; Time Factors; Type C Phospholipases; Wortmannin

Topics: Androstadienes; Animals; Cell Line; COS Cells; Enzyme Inhibitors; ErbB Receptors; Heterotrimeric GTP-Binding Proteins; Lysophospholipids; Models, Chemical; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protease Inhibitors; Protein Isoforms; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Staurosporine; Thiophenes; Transcriptional Activation; Tyrphostins; Wortmannin

Topics: Adenoviridae; Amino Acid Motifs; Amino Acid Sequence; Analysis of Variance; Androstadienes; Animals; Apoptosis; Blotting, Western; Brain; Carrier Proteins; Cell Fractionation; Cells, Cultured; Cloning, Molecular; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homer Scaffolding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; Leucine; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proline; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Synaptophysin; Transfection; Wortmannin

Topics: Adenosine Triphosphate; Androstadienes; Biological Assay; Class Ib Phosphatidylinositol 3-Kinase; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Isoenzymes; Lipid Metabolism; Microchemistry; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phospholipids; Phosphorus Radioisotopes; Quercetin; Recombinant Proteins; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin

Topics: Amino Acid Sequence; Amino Acids; Androstadienes; Animals; Antigens, CD; Antigens, Differentiation; Binding Sites; Carcinoembryonic Antigen; Cell Adhesion Molecules; Cell Line; Cell Polarity; Cytoplasm; Desmosomes; Dogs; Epithelial Cells; Mice; Microscopy, Confocal; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Isoforms; Protein Structure, Tertiary; Rats; Recombinant Proteins; Sequence Deletion; Staurosporine; Vanadates; Wortmannin

Topics: Androstadienes; Animals; Entamoeba histolytica; Enzyme Inhibitors; Erythrocytes; Genistein; Humans; Microscopy, Electron, Scanning; Phagocytosis; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tyrphostins; Wortmannin

Topics: Actin Cytoskeleton; Actins; ADP Ribose Transferases; Androstadienes; Bacterial Adhesion; Bacterial Proteins; Botulinum Toxins; Colony Count, Microbial; Cytochalasin D; Cytoplasm; Cytoskeleton; Enzyme Inhibitors; Genistein; HeLa Cells; Humans; Lipoxygenase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Plasminogen Activators; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Signal Transduction; Staurosporine; Wortmannin; Yersinia pestis

Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin

Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Calcium; Cells, Cultured; Chromatography; Chromones; Cricetinae; Dose-Response Relationship, Drug; Indoles; Inositol Phosphates; Insulin; Maleimides; Morpholines; Phosphorylation; Protein Kinase C; Rats; Receptor, Insulin; Receptors, Adrenergic, alpha-1; Staurosporine; Wortmannin

Topics: Actins; Androstadienes; Antibodies, Monoclonal; Antigens, CD; Blood Platelets; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cross-Linking Reagents; Cytoskeleton; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoprecipitation; Integrin beta3; Integrins; Ions; Membrane Glycoproteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation; Protein Binding; Protein Kinase C; Receptors, Cell Surface; Signal Transduction; Staurosporine; Tetraspanin 29; Time Factors; Wortmannin

Topics: Androstadienes; Animals; Aorta; Calcium; Carbazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Ferrous Compounds; Genistein; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proadifen; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Wortmannin

Topics: Amphiregulin; Androstadienes; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Line, Tumor; Culture Media, Serum-Free; EGF Family of Proteins; Enzyme Inhibitors; Flavonoids; Glycoproteins; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Models, Biological; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Wortmannin

Topics: Analysis of Variance; Androstadienes; Animals; Benzoquinones; Biological Transport, Active; Blotting, Western; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; DNA Primers; Dose-Response Relationship, Drug; Embryo, Mammalian; Fluorescent Antibody Technique; Gallopamil; Genistein; Indoles; Insulin; Ion Transport; Lactams, Macrocyclic; Maleimides; Mice; Nifedipine; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; Signal Transduction; Staurosporine; Stem Cells; Wortmannin

Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Enzyme Inhibitors; Evodia; Gene Expression; Genes, p53; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; MAP Kinase Signaling System; Melanoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Sirtuin 1; Sirtuins; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 8; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Membrane Microdomains; Oligodendroglioma; PC12 Cells; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Rats; Sphingosine; Staurosporine; Transfection; Tumor Suppressor Proteins; Wortmannin

Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, High Pressure Liquid; Diterpenes; Diterpenes, Kaurane; Enzyme Activation; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Molecular Structure; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrrolidinones; Staurosporine; Time Factors; Type C Phospholipases; U937 Cells; Ultraviolet Rays; Wortmannin

Topics: Adenoviridae; Androstadienes; Apoptosis; Cadherins; Caspases; Cell Survival; Cells, Cultured; Dactinomycin; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoblotting; Immunohistochemistry; Immunosuppressive Agents; MAP Kinase Signaling System; Microscopy, Fluorescence; Models, Biological; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Sirolimus; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin

Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin

Topics: Albumins; Androstadienes; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cell Fractionation; Cell Line; Chromones; Endocytosis; Imidazoles; Kidney Tubules, Proximal; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Angiotensin, Type 2; Staurosporine; Sus scrofa; Wortmannin

Topics: Androstadienes; Bacterial Proteins; Campylobacter jejuni; Caveolae; Cell Line; Chromones; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Filipin; Genistein; GTP-Binding Proteins; Humans; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Receptors, G-Protein-Coupled; Signal Transduction; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Antiprotozoal Agents; Cell Membrane; Cell Nucleus; Chromatin; Enzyme Inhibitors; Flagella; Genistein; Growth Inhibitors; Inhibitory Concentration 50; Microscopy, Electron, Transmission; Organelles; Parasitic Sensitivity Tests; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Staurosporine; Trypanosoma cruzi; Wortmannin

Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Blotting, Western; Calcium; Cell Line; Cell Line, Tumor; Cricetinae; Endocytosis; Estradiol; Estrogen Receptor alpha; Estrogens; Fulvestrant; Humans; Microscopy, Confocal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C-delta; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1; Staurosporine; Transfection; Wortmannin

Topics: Androstadienes; Animals; Calcium; Cell Line; Cytochalasins; Genistein; Ionophores; Macaca mulatta; Staurosporine; Toxoplasma; Vacuoles; Wortmannin

Topics: Androstadienes; Animals; Cimetidine; Dexamethasone; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Male; Nitrobenzoates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Channel Blockers; Protein Kinase Inhibitors; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Wortmannin

Topics: Androstadienes; Animals; Brefeldin A; Cell Line; Cell Membrane; Endosomes; Enzyme Inhibitors; Epithelial Cells; Female; Glucose; Glucose Transporter Type 1; Golgi Apparatus; Green Fluorescent Proteins; Lactation; Lactose; Macrolides; Mammary Glands, Animal; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prolactin; Protein Kinase C; Protein Synthesis Inhibitors; Protein Transport; Recombinant Fusion Proteins; Staurosporine; Time Factors; Transfection; Wortmannin

Topics: Androstadienes; Animals; Antigens, Surface; Apoptosis; Cell Adhesion; Cells, Cultured; Cycloheximide; Endothelial Cells; Enzyme Inhibitors; Humans; Interleukin-1beta; Membrane Potential, Mitochondrial; Mesenchymal Stem Cells; NADH Dehydrogenase; Okadaic Acid; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tumor Necrosis Factor-alpha; von Willebrand Factor; Wortmannin

Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Androstadienes; Anesthetics, Inhalation; Animals; Apoptosis; Biomarkers; Cells, Cultured; Cerebral Cortex; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Isoflurane; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Staurosporine; Wortmannin

Topics: Androstadienes; Chromones; Culture Media; Enzyme Inhibitors; Genistein; Giardia lamblia; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Protozoan Proteins; Staurosporine; Wortmannin

Topics: Adenocarcinoma; Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Radiation; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lasers, Gas; Low-Level Light Therapy; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Staurosporine; Time Factors; Transfection; Wortmannin

Topics: Actins; Androstadienes; Animals; Cell Line; Cytochalasin D; Dynamins; Epithelial Cells; Genistein; Macaca mulatta; Mice; Myosins; Protein Kinase Inhibitors; Staurosporine; Toxoplasma; Wortmannin