staurosporine has been researched along with ucn 1028 c in 176 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 134 (76.14) | 18.2507 |
| 2000's | 41 (23.30) | 29.6817 |
| 2010's | 1 (0.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, LL; Ren, JX; Wei, YQ; Xie, HZ; Yang, L; Yang, SY; Zou, J | 1 |
| Rodríguez Del Castillo, A; Trifaró, JM; Vitale, ML | 1 |
| García-Sáinz, JA; López-Gómez, FJ; Robles-Flores, M | 1 |
| Forgo, J; Helmle-Kolb, C; Mrkic, B; Murer, H | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A | 1 |
| Luna, EJ; Shariff, A | 1 |
| Brown, EJ; Zheleznyak, A | 1 |
| Bevan, JA; Henrion, D; Laher, I; Laporte, R | 1 |
| Chambers, TC; Kuo, JF; Zheng, B | 1 |
| Durum, SK; Kung, HF; Ramsburg, EA; Smith, MR | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Messina, JL | 1 |
| Tamaoki, T | 1 |
| Furuyama, J; Ikemoto, H; Matsumoto, T; Nakano, A; Tani, E | 1 |
| Gamou, S; Shimizu, N | 1 |
| Denison, MS; Madhukar, BV; Schafer, MW; Swanson, HI; Tullis, K | 1 |
| Schiffrin, EL; Tolloczko, B; Touyz, RM | 1 |
| Artini, M; Avantaggiati, ML; Balsano, C; Chirillo, P; Costanzo, A; Levrero, M; Natoli, G | 1 |
| Grant, S; Jarvis, WD; Povirk, LF; Traylor, RS; Turner, AJ | 1 |
| Hoffman, PL; Iorio, KR; Snell, LD; Tabakoff, B | 1 |
| Thurston, G; Turner, D | 1 |
| Fumo, P; Kuncio, GS; Ziyadeh, FN | 1 |
| Rozanski, GJ; Witt, RC | 1 |
| Massry, SG; Ni, Z; Smogorzewski, M | 1 |
| Asaoka, Y; Chang, WC; Liu, YW; Suzuki, H; Yamamoto, S; Yoshimoto, T | 1 |
| Aviv, A; Cho, JH; Kimura, M; Reeves, JP | 1 |
| Miller, LJ; Ozcelebi, F | 1 |
| Feng, CJ; Ibrahim, IN; Kadowitz, PJ; Kaye, AD; Nossaman, BD | 1 |
| Lipsius, SL; Wang, YG | 1 |
| Bell, LL; Cheung, JY; Lynch, CJ; Miller, BA | 1 |
| Houslay, MD; Savage, A; Zeng, L | 1 |
| Hargrove, ME; Patel, AD; Ting, CC; Wang, J | 1 |
| Budworth, J; Gescher, A | 1 |
| Guillemain, I; Rossignol, B | 1 |
| Schiffrin, EL; Touyz, RM | 1 |
| Giaid, A; Harrison, DG; Kurz, S; Münzel, T; Stewart, DJ | 1 |
| Larsen, PM; Wolniak, SM | 1 |
| Arbour, N; Houde, M; Mandeville, R; Masure, S; Opdenakker, G; Oth, D; Rochefort, D; Tremblay, P | 1 |
| Bitrick, MS; Smith, TL | 1 |
| Barman, SA; Ikeda, SR | 1 |
| Brooks, BJ; Elliott, MS; Eriotou, P; Hart, KL; Kelly, DF; Morris, RC; Sagar, S | 1 |
| Lefevre, J; MacDonald, ML; Redman, C | 1 |
| Aburto, T; Deth, RC; Jinsi, A; Zhu, Q | 1 |
| Gopalakrishna, R; Gundimeda, U; Hinton, DR; Murphy, TL; Ryan, SJ; Sakamoto, T; Soriano, D; Spee, C | 1 |
| Ciudad, CJ; Noé, V | 1 |
| Kopp, UC; Smith, LA | 1 |
| Ibuki, Y; Imagawa, T; Suketa, Y | 1 |
| Cioffi, J; Edberg, J; Huang, R; Kimberly, R; Mayer, L | 1 |
| Abayasekara, RE; Flint, AP; Searle, MJ | 1 |
| Azzi, A; Boscoboinik, D; Galeotti, T | 1 |
| Baglioni, C; Gorospe, M; Kumar, S | 1 |
| Bischer, P; Cantu, AR; Pavone, A; Reiners, JJ; Schöller, A | 1 |
| Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y | 1 |
| Chen, YQ; Diglio, CA; Honn, KV; Tang, DG | 1 |
| Colman, RW; Puri, RN | 1 |
| Niedbala, MJ; Stein-Picarella, M | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| De Pont, JJ; Hoenderop, JG; Van Emst-De Vries, SE; Van Hoof, HJ; Van Mackelenbergh, MG; Willems, PH | 1 |
| Reyland, ME | 1 |
| Henrion, D; Laher, I | 1 |
| Duty, L; Gorelik, E; Kim, M; Prezioso, JA; Tweardy, DJ; Wang, J | 1 |
| Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R | 1 |
| Abraham, NG; Laniado-Schwartzman, M; Stoltz, RA | 1 |
| Agnew, WS; Bendahhou, S; Cummins, TR; Potts, JF; Tong, J | 1 |
| Albar, JP; De Miguel, F; Esbrit, P; García-Ocaña, A; Peñaranda, C; Sarasa, JL | 1 |
| Chin, WW; Cohen, DM; Gullans, SR | 1 |
| Chikvashvili, D; Levin, G; Lotan, I; Moran, O; Peretz, T; Thornhill, WB | 1 |
| Daphna-Iken, D; Morrison, AR; Rzymkiewicz, DM; Srivastava, S; Tetsuka, T | 1 |
| Basson, MD; Han, O; Hong, F; Li, GD; Sumpio, BE | 1 |
| Balasubramanyam, M; Gardner, JP | 1 |
| Asano, M; Ito, K; Ito, KM; Matsunaga, K; Miura, M; Nagumo, H; Sakurada, K; Sasaki, Y; Seto, M | 1 |
| Chakravarthy, BR; Mealing, GA; Morley, P; Tsang, BK; Whitfield, JF | 1 |
| Gerritsen, ME; Moatter, T | 1 |
| Chang, JP; Jobin, RM; Neumann, CM; Van Goor, F | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Fujimoto, S; Satake, N; Shibata, S | 1 |
| Ridderstråle, M; Tornqvist, H | 1 |
| Bonjour, JP; Caverzasio, J; Palmer, G | 1 |
| Bardes, ES; Bell, RM; Buehrer, BM | 1 |
| Higashiyama, M; Ishikawa, SE; Kusaka, I; Nagasaka, S; Saito, T | 1 |
| Dickens, G; Guroff, G; Lavarreda, M; Zheng, WH | 1 |
| Chakravarthy, B; Durkin, JP; Mealing, G; Morley, P; Small, D; Song, D; Tremblay, R | 1 |
| Kozawa, O; Suzuki, A; Tokuda, H; Uematsu, T | 1 |
| Brown, ER; Dempsey, BK; Lew, DB; Malik, KU; Wright, HM | 1 |
| Cánepa, ET; Varone, CL | 1 |
| Nash, MS; Osborne, NN; Wood, JP | 1 |
| Goodyer, CG; Oh, LY; Olivier, A; Yong, VW | 1 |
| Goretzki, L; Mueller, BM | 1 |
| Murai, A; Nakahata, N; Nakamura, H; Ohizumi, Y; Rho, MC | 1 |
| Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H | 1 |
| Keiser, HR; Oriji, GK | 1 |
| Aballay, A; Arenas, NG; Mayorga, LS; Quest, AF | 1 |
| Armstrong, SC; Ganote, CE; Hoover, DB; Shivell, LC | 1 |
| Levi, G; Patrizio, M; Slepko, N | 1 |
| Chen, C; Clarke, IJ; Wu, D | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Maurelli, S | 1 |
| Kaida, T; Kozawa, O; Suzuki, A; Tokuda, H; Uematsu, T | 1 |
| Bremerich, DH; Jones, KA; Lorenz, RR; Shumway, R; Warner, DO | 1 |
| Han, O; Ikeda, M; Male, P; Mills, I; Sumpio, BE; Takei, T | 1 |
| Gekle, M; Oberleithner, H; Silbernagl, S | 1 |
| Church, DJ; Lang, U; Morabito, D; Rebsamen, MC; Vallotton, MB | 1 |
| Kozawa, O; Suzuki, A; Uematsu, T | 1 |
| Kubo, M; Quayle, JM; Standen, NB | 1 |
| Chambers, TC; Cloud-Heflin, BA; Kumar, A; Mehta, KD | 1 |
| Choe, YS; Kim, K; Lee, YJ; Sun, W | 1 |
| Fukuzawa, K; Houchi, H; Oka, M; Okuno, M; Tokumura, A; Tsuchiya, K | 1 |
| Karimi, K; Lennartz, MR | 1 |
| Searl, TJ; Silinsky, EM | 1 |
| Baekgaard, A; Bindslev, N | 1 |
| Inoguchi, T; Kuroki, T; Nawata, H; Ueda, F; Umeda, F | 1 |
| Devoe, G; Gear, R; Heffelfinger, SC; Miller, MA | 1 |
| Kletsas, D; Ottaviani, E; Sassi, D | 1 |
| Basson, MD; Hong, F | 1 |
| Fukao, M; Hattori, Y; Kanno, M; Kitabatake, A; Sakuma, I; Sato, A | 1 |
| Kamp, DW; Panos, RJ; Pollack, N; Sporn, PH; Wu, KI | 1 |
| Amlal, H; Goel, A; Soleimani, M | 1 |
| Hagiwara, Y; Hanada, M; Kambe, T; Kubo, T; Saito, E | 1 |
| Ritzenthaler, J; Roman, J | 1 |
| Hashimoto, T; Hojo, K; Kawamata, T; Maeda, K; Nakai, M; Tanaka, C; Taniguchi, T; Terashima, A | 1 |
| Egesten, A; Malm, J | 1 |
| Hiraoka, S; Kitamura, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Tsutsui, S | 1 |
| Hattori, Y; Kanno, M; Kitabatake, A; Kohya, T; Moriishi, K; Oguma, K; Sasaki, M; Tomita, F | 1 |
| Haller, H; Kupprion, C; Lindschau, C; Luft, FC; Maasch, C; Wellner, M | 1 |
| Nicolás, JM; Renard-Rooney, DC; Thomas, AP | 1 |
| Aono, S; Nakagawa, S; Reynolds, AB; Takeichi, M | 1 |
| Fujita, T; Hayashi, M; Shimosawa, T | 1 |
| Coultrap, SJ; Machu, TK; Sun, H; Tenner, TE | 1 |
| Chaqour, B; Howard, PS; Macarak, EJ; Richards, CF | 1 |
| Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS | 1 |
| Alexander, BT; Granger, JP; Kanashiro, CA; Khalil, RA | 1 |
| Amendola, A; Oliverio, S; Piacentini, M; Rodolfo, C; Spinedi, A | 1 |
| Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Knox, FG; Liang, M | 1 |
| Josefsen, D; Myklebust, JH; Sioud, M; Smeland, EB | 1 |
| Lerma, J; López-García, JC; Rodríguez-Moreno, A | 1 |
| Grant, S; Jarvis, WD | 1 |
| Alexander, SR; Kishimoto, TK; Walcheck, B | 1 |
| Allen, JC; Kahn, AM; Seidel, CL; Song, T | 1 |
| Gupte, SA; Ochi, R; Okada, T; Tateyama, M | 1 |
| DiGennaro, JA; Larsen, EC; Lennartz, MR; Loegering, DJ; Mazurkiewicz, JE; Mehta, S; Saito, N | 1 |
| Björklund, S; Dugué, B; Titievsky, A; Törnquist, K; Tuominen, RK; Vainio, PJ | 1 |
| Cantwell, AM; Long, W; Longo, LD; Miguel, C; Nanyonga, AT; Saito, T; Windemuth, RS; Zhang, L; Zhao, Y | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Chen, CC; Chen, JJ; Chou, CY | 1 |
| Mancuso, P; Peters-Golden, M | 1 |
| Katsuyama, R; Kawasaki, T; Morioka, A; Oka, S | 1 |
| Fenoll-Brunet, MR; Garcia, N; Lanuza, MA; Nelson, PG; Santafe, M; Tomas, J | 1 |
| Altura, BM; Altura, BT; Li, W; Zheng, T | 1 |
| Barman, SA | 1 |
| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
| Conseil, G; Di Pietro, A; Gamarro, F; Goffeau, A; Hofmann, J; Jault, JM; Perez-Victoria, JM | 1 |
| Hatakeyama, D; Ito, H; Kato, K; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Dohi, Y; Kojima, M; Miyagawa, K; Sato, K; Suzuki, S; Takase, H; van Breemen, C | 1 |
| Hong, HY; Varvayanis, S; Yen, A | 1 |
| Bartels, W; Boissel, JP; Buerke, M; Darius, H; Grosser, T; Ibe, W; Lindemann, S; Meyer, J | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Lange, Y; Steck, TL; Ye, J | 1 |
| Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tokuda, H; Uematsu, T | 1 |
| da Rocha, AB; Mans, DR; Regner, A; Schwartsmann, G | 1 |
| Blomhoff, HK; Myklebust, JH; Rusten, LS; Smeland, EB; Stokke, T | 1 |
| Akita, Y; Gutierrez-Hartmann, A; Manning, N; Pickett, CA | 1 |
| Alper, RH; Mize, AL | 1 |
| De Souza, W; Limongi, CL; Rozental, S | 1 |
| Bloom, DA; Jaiswal, AK | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Agrawal, DK; DelCore, MG; Hunter, WJ; Krueger, KD | 1 |
| John, SA; Kodama, I; Lee, JK; Uozumi, N; Zhang, L | 1 |
| Del Poeta, M; Hannun, YA; Heung, LJ; Luberto, C; Plowden, A | 1 |
| Dailianis, S; Kaloyianni, M | 1 |
| Auberger, P; Brambilla, C; Coll, JL; Dubrez-Daloz, L; Favrot, MC; Hurbin, A; Mari, B | 1 |
| Canaff, L; Chihara, K; Hendy, GN; Kaji, H; Naito, J; Sowa, H; Sugimoto, T; Tobimatsu, T | 1 |
| Albuquerque-Xavier, AC; Benchimol, M; De Souza Fernandes, S; De Souza, W; Fernandes de Souza, W; Leve, F; Martins de Araujo, W; Montesano, G; Morgado-Díaz, JA; Oliveira, SS; Redondo, PA; Tanaka, MN | 1 |
| Berg, DT; Calnek, D; Grinnell, BW; Gupta, A; O'Brien, LA; Richardson, MA | 1 |
| Bonen, A; Coort, SL; El Hasnaoui, M; Glatz, JF; Habets, DD; Hue, L; Luiken, JJ; Pelsers, MM; Rider, MH; Vertommen, D; Viollet, B | 1 |
| Clark, OH; Duh, QY; Herfarth, C; Hoelting, T | 1 |
| Cao, CQ; Grant, R; Mo, G; O'Donnell, D; Ragsdale, DS; Séguéla, P | 1 |
2 review(s) available for staurosporine and ucn 1028 c
| Article | Year |
|---|---|
Protein kinase C targeting in antineoplastic treatment strategies.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cell Survival; Cytoprotection; Enzyme Inhibitors; Humans; Lactones; Macrolides; Mitogen-Activated Protein Kinase Kinases; Naphthalenes; Protein Kinase C; Sphingosine; Staurosporine | 1999 |
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
Topics: Adolescent; Adult; Antineoplastic Agents; Apoptosis; Bryostatins; Cell Division; Child; Child, Preschool; Enzyme Activation; Enzyme Inhibitors; Glioma; Humans; Infant; Lactones; Macrolides; Mutation; Naphthalenes; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Protein Kinase C; Sphingosine; Staurosporine | 2002 |
174 other study(ies) available for staurosporine and ucn 1028 c
| Article | Year |
|---|---|
Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors.
Topics: Computer Simulation; Intracellular Signaling Peptides and Proteins; Models, Molecular; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Small Molecule Libraries; Software; Structure-Activity Relationship; Syk Kinase | 2009 |
Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation.
Topics: Actins; Adrenal Medulla; Alkaloids; Animals; Calcium; Cattle; Enzyme Activation; Exocytosis; Kinetics; Macromolecular Substances; Microscopy, Fluorescence; Naphthalenes; Nicotine; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Receptors, Nicotinic; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Staurosporine and calphostin-C inhibit the phorbol ester-induced decrease of protein kinase C activity in rat hepatocytes.
Topics: Alkaloids; Animals; Chromatography, DEAE-Cellulose; Enzyme Activation; Female; Liver; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Apical and basolateral Na/H exchange in cultured murine proximal tubule cells (MCT): effect of parathyroid hormone (PTH).
Topics: Alkaloids; Amiloride; Animals; Carrier Proteins; Cell Line; Hydrogen; Hydrogen-Ion Concentration; Intracellular Fluid; Ion Transport; Kidney Tubules, Proximal; Mice; Naphthalenes; Parathyroid Hormone; Phosphates; Polycyclic Compounds; Protein Kinase C; Protein Kinases; Sodium; Sodium-Hydrogen Exchangers; Staurosporine | 1992 |
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes.
Topics: Actins; Alkaloids; Animals; Calcium; Cell Membrane; Dictyostelium; Diglycerides; Kinetics; Macromolecular Substances; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Amino Acid Sequence; Biological Transport; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Eye Proteins; Humans; Immunoglobulin G; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; Naphthalenes; Phagocytosis; Phagosomes; Piperazines; Polycyclic Compounds; Protein Kinase C; Rod Opsins; Signal Transduction; Staurosporine; Sulfonamides | 1992 |
Angiotensin II amplifies arterial contractile response to norepinephrine without increasing Ca++ influx: role of protein kinase C.
Topics: Alkaloids; Angiotensin II; Animals; Caffeine; Calcium; Drug Synergism; Histamine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rabbits; Staurosporine | 1992 |
Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Ethers, Cyclic; Humans; KB Cells; Membrane Glycoproteins; Naphthalenes; Okadaic Acid; Peptide Mapping; Phenotype; Phospholipid Ethers; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Vinblastine | 1992 |
Components of the protein kinase C pathway induce Ia expression after injection into macrophages.
Topics: Alkaloids; Animals; Calcimycin; Diglycerides; Histocompatibility Antigens Class II; In Vitro Techniques; Interferon-gamma; Isoquinolines; Macrophages; Mice; Mice, Inbred C3H; Microinjections; Naphthalenes; Phospholipases A; Phospholipases A2; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzimidazoles; Calmodulin; Coronary Disease; Heart; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Naphthalenes; Piperazines; Polycyclic Compounds; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Trifluoperazine | 1992 |
Rapid regulation of albumin transcription by insulin and phorbol esters in rat hepatoma cells.
Topics: Albumins; Alkaloids; Animals; Cycloheximide; Gene Expression Regulation; Insulin; Kinetics; Liver Neoplasms, Experimental; Naphthalenes; Phosphoenolpyruvate Carboxykinase (GTP); Polycyclic Compounds; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors.
Topics: Alkaloids; Animals; Avian Sarcoma Viruses; Brain; Cattle; Cell Line; Chick Embryo; Molecular Structure; Myocardium; Naphthalenes; Oncogene Protein pp60(v-src); Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Structure-Activity Relationship | 1991 |
Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor.
Topics: Alkaloids; Antibiotics, Antineoplastic; Apoptosis; Autoradiography; Blotting, Northern; Blotting, Western; Cell Count; Cell Line; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glioma; Humans; Naphthalenes; Protein Kinase C; Staurosporine; Thymidine; Tumor Cells, Cultured | 1995 |
Calphostin-C stimulates epidermal growth factor receptor phosphorylation and internalization via light-dependent mechanism.
Topics: Alkaloids; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Light; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Naphthalenes; Peptide Mapping; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Proteins; Staurosporine; Trypsin; Tumor Cells, Cultured; Tyrosine | 1994 |
Protein kinase C is not involved in Ah receptor transformation and DNA binding.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Cytosol; DNA; Enzyme Induction; Guinea Pigs; Isoquinolines; Liver; Male; Molecular Sequence Data; Naphthalenes; Piperazines; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Protein Binding; Protein Kinase C; Receptors, Aryl Hydrocarbon; Signal Transduction; Staurosporine | 1993 |
Insulin attenuates agonist-evoked calcium transients in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Diltiazem; Fluorescent Dyes; Fura-2; Humans; Insulin; Mesenteric Arteries; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Staurosporine; Terpenes; Thapsigargin | 1994 |
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.
Topics: Alkaloids; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; HeLa Cells; Hepatitis B virus; Humans; Isoquinolines; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenes; Oligodeoxyribonucleotides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Vaccinia virus; Viral Regulatory and Accessory Proteins | 1994 |
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Gossypol; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Naphthalenes; Perylene; Phenanthridines; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Time Factors; Tumor Cells, Cultured | 1994 |
Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Glycine; Intracellular Fluid; Kinetics; Magnesium Sulfate; N-Methylaspartate; Naphthalenes; Neurons; Pipecolic Acids; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Thrombin-induced increase of F-actin in human umbilical vein endothelial cells.
Topics: Actins; Alkaloids; Calcium; Capillary Permeability; Cells, Cultured; Cytoskeleton; Diterpenes; Endothelium, Vascular; Humans; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Umbilical Veins | 1994 |
PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line.
Topics: Alkaloids; Analysis of Variance; Animals; Cell Line; Cell Line, Transformed; Collagen; Enzyme Activation; Gene Expression; Glomerular Mesangium; Glucose; Kinetics; Luciferases; Mannitol; Mice; Mice, Inbred Strains; Naphthalenes; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1994 |
Interleukin-1 enhances beta-responsiveness of cardiac L-type calcium current suppressed by acidosis.
Topics: Acidosis; Alkaloids; Amiloride; Animals; Calcium Channels; Cells, Cultured; Guinea Pigs; Heart; Heart Ventricles; Humans; Interleukin-1; Isoproterenol; Kinetics; Male; Membrane Potentials; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Recombinant Proteins; Sodium; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Effects of parathyroid hormone on cytosolic calcium of rat adipocytes.
Topics: Adipocytes; Alkaloids; Animals; Calcium; Cells, Cultured; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Naphthalenes; Nifedipine; Parathyroid Hormone; Peptide Fragments; Pertussis Toxin; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Teriparatide; Verapamil; Virulence Factors, Bordetella | 1994 |
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Topics: Alkaloids; Arachidonate 12-Lipoxygenase; Carcinoma, Squamous Cell; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Humans; Naphthalenes; Phosphatidylinositol Phosphates; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Inhibition of Ca2+ entry by Ca2+ overloading of intracellular Ca2+ stores in human platelets.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Blood Platelets; Calcium; Calcium Channels; Carrier Proteins; Cell Membrane Permeability; Cricetinae; Fura-2; Humans; Inositol 1,4,5-Trisphosphate; Naphthalenes; Ouabain; Polycyclic Compounds; Protein Kinase C; Sodium; Sodium-Calcium Exchanger; Staurosporine; Terpenes; Thapsigargin; Thrombin | 1994 |
Phosphopeptide mapping of cholecystokinin receptors on agonist-stimulated native pancreatic acinar cells.
Topics: Adenosine Triphosphate; Alkaloids; Amino Acid Sequence; Animals; Carbachol; Cell Membrane; Cholecystokinin; Cyanogen Bromide; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Molecular Sequence Data; Naphthalenes; Pancreas; Peptide Mapping; Phosphopeptides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Influence of protein kinase C inhibitors on vasoconstrictor responses in the pulmonary vascular bed of cat and rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Angiotensin II; Animals; Cats; Female; Lung; Male; Naphthalenes; Norepinephrine; Polycyclic Compounds; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Staurosporine; Thromboxane A2; Vasoconstriction | 1995 |
Acetylcholine activates a glibenclamide-sensitive K+ current in cat atrial myocytes.
Topics: Acetylcholine; Alkaloids; Animals; Calcium; Cats; Female; Glyburide; Heart Atria; In Vitro Techniques; Ion Transport; Male; Myocardium; Naphthalenes; Pirenzepine; Polycyclic Compounds; Potassium; Potassium Channels; Protein Kinase C; Receptors, Muscarinic; Second Messenger Systems; Sodium; Staurosporine | 1995 |
Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation.
Topics: Adult; Alkaloids; Analog-Digital Conversion; Biological Transport; Bucladesine; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Erythroid Precursor Cells; Erythropoietin; Genistein; Humans; Image Processing, Computer-Assisted; Indoles; Intercellular Signaling Peptides and Proteins; Intracellular Fluid; Isoflavones; Isoquinolines; Naphthalenes; Peptides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyrroles; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Videotape Recording; Wasp Venoms | 1994 |
A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes.
Topics: Adenylyl Cyclases; Alkaline Phosphatase; Alkaloids; Animals; Arginine Vasopressin; Benzophenanthridines; Cell Adhesion; Cells, Cultured; Collagen; Cyclic AMP; Drug Tolerance; Ethers, Cyclic; Glucagon; Liver; Male; Naphthalenes; Okadaic Acid; Phenanthridines; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine | 1995 |
Differential requirement of protein tyrosine kinase and protein kinase C in the generation of IL-2-induced LAK cell and alpha CD3-induced CD3-AK cell responses.
Topics: Alkaloids; Animals; Benzoquinones; Female; Genistein; Interleukin-2; Isoflavones; Killer Cells, Lymphokine-Activated; Lactams, Macrocyclic; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Naphthalenes; Perforin; Polycyclic Compounds; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Interleukin-2; Recombinant Proteins; Rifabutin; RNA, Messenger; Signal Transduction; Staurosporine | 1995 |
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
Topics: Alkaloids; Breast Neoplasms; Cell Membrane; Cytosol; Humans; Immunoblotting; Indoles; Naphthalenes; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
Protein kinase C and phospholipase D activation in rat parotid glands.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Glycerophospholipids; Male; Naphthalenes; Parotid Gland; Phenanthridines; Phosphatidic Acids; Phospholipase D; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Role of protein kinase C in the anti-aggregatory effects of endothelin-1 on human platelets.
Topics: Adult; Alkaloids; Amiloride; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Endothelins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Naphthalenes; Platelet Aggregation; Platelet Aggregation Inhibitors; Polycyclic Compounds; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Thrombin | 1995 |
Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
Topics: Alkaloids; Angiotensin II; Animals; Aorta, Thoracic; Drug Tolerance; Endothelins; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Phenylephrine; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rabbits; Serotonin; Staurosporine; Vasoconstriction | 1995 |
The timing of protein kinase activation events in the cascade that regulates mitotic progression in Tradescantia stamen hair cells.
Topics: Alkaloids; Anaphase; Carbazoles; Cell Division; Cells, Cultured; Enzyme Activation; Indole Alkaloids; Mitosis; Naphthalenes; Oligopeptides; Plant Cells; Plants; Polycyclic Compounds; Protein Kinase C; Staurosporine | 1995 |
Differential effects of PKC inhibitors on gelatinase B and interleukin 6 production in the mouse macrophage.
Topics: Alkaloids; Animals; Biological Assay; Blotting, Northern; Cell Line, Transformed; Collagenases; Gene Expression; Interleukin-6; Macrophages; Matrix Metalloproteinase 9; Mice; Naphthalenes; Nitric Oxide; Polycyclic Compounds; Protein Kinase C; RNA, Messenger; Staurosporine; Tumor Necrosis Factor-alpha | 1995 |
Lack of involvement of protein kinase C in ethanol-induced inhibition of metabotropic-glutamate receptor function in primary cultures of astrocytes.
Topics: Alkaloids; Animals; Astrocytes; Cells, Cultured; Enzyme Activation; Ethanol; Female; Naphthalenes; Polycyclic Compounds; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester potentiation of canine pulmonary vasoreactivity to histamine.
Topics: Alkaloids; Animals; Blood Vessels; Calcium Channel Blockers; Compliance; Dogs; Drug Synergism; Female; Histamine; In Vitro Techniques; Male; Naphthalenes; Nifedipine; Protein Kinase C; Pulmonary Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vascular Resistance | 1995 |
Activation of transfer RNA-guanine ribosyltransferase by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Buffers; Diphosphates; Enzyme Activation; Enzyme Reactivators; Enzyme Stability; Isoquinolines; Liver; Naphthalenes; Pentosyltransferases; Phosphoric Monoester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sphingosine; Staurosporine | 1995 |
Inhibition of diacylglycerol kinase by the antitumor agent calphostin C. Evidence for similarity between the active site of diacylglycerol kinase and the regulatory site of protein kinase C.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Binding Sites; Diacylglycerol Kinase; Doxorubicin; Iron; Kinetics; Male; Naphthalenes; Organometallic Compounds; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Staurosporine; Swine; Testis | 1995 |
Involvement of protein kinase C activation in alpha 2-adrenoceptor-mediated contractions of rabbit saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Brimonidine Tartrate; Calcium; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Saphenous Vein; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Migration of retinal pigment epithelium cells in vitro is regulated by protein kinase C.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Cattle; Cell Movement; Cell Survival; Cells, Cultured; Cytoskeleton; Naphthalenes; Pigment Epithelium of Eye; Protein Kinase C; Staurosporine; Subcellular Fractions; Wound Healing | 1995 |
Protein kinase C inhibitors reduce phorbol ester-induced resistance to methotrexate in Chinese hamster ovary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; CHO Cells; Colony-Forming Units Assay; Cricetinae; Drug Resistance; Glycyrrhetinic Acid; Isoquinolines; Methotrexate; Molecular Sequence Data; Naphthalenes; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine | 1995 |
A role for protein kinase C in bradykinin-mediated activation of renal pelvic sensory receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Enzyme Activation; Isoquinolines; Kidney Pelvis; Male; Naphthalenes; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Staurosporine | 1995 |
A role of protein kinase C in the alteration of renal glucose-6-phosphatase activity caused by fluoride.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Membrane; Cytosol; Down-Regulation; Fluorides; Glucose-6-Phosphatase; In Vitro Techniques; Isoquinolines; Kidney; Male; Microsomes; Naphthalenes; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1995 |
B cell differentiation factor-induced human B cell maturation: stimulation of intracellular calcium release.
Topics: Alkaloids; B-Lymphocytes; Calcium; Cell Differentiation; Cytoplasm; Humans; Inositol Phosphates; Interleukin-6; Lymphocyte Activation; Naphthalenes; Pertussis Toxin; Protein Kinase C; Signal Transduction; Staphylococcus aureus; Staurosporine; Virulence Factors, Bordetella | 1995 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
Regulation of the TNF-alpha receptor in human osteosarcoma cells: role of microtubules and of protein kinase C.
Topics: Alkaloids; Cell Membrane; Cycloheximide; Ethers, Cyclic; Humans; Kinetics; Microtubules; Naphthalenes; Okadaic Acid; Osteosarcoma; Phosphoprotein Phosphatases; Polycyclic Compounds; Protein Kinase C; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine | 1993 |
Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.
Topics: Alkaloids; Blotting, Western; Cycloheximide; Enzyme Activation; Humans; Interleukin-1; Kinetics; Naphthalenes; Polycyclic Compounds; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoquinolines; Liver Neoplasms, Experimental; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction | 1993 |
Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Alkaloids; Animals; Aorta; Base Sequence; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Mice; Microcirculation; Molecular Sequence Data; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoadhesin; Receptors, Fibronectin; Receptors, Vitronectin; Staurosporine; Vinculin | 1993 |
Thrombin- and cathepsin G-induced platelet aggregation: effect of protein kinase C inhibitors.
Topics: Alkaloids; Amino Acid Sequence; Blood Platelets; Cathepsin G; Cathepsins; Flavonoids; Flavonols; Humans; In Vitro Techniques; Molecular Sequence Data; Naphthalenes; Oligopeptides; Platelet Aggregation; Polycyclic Compounds; Protein Kinase C; Serine Endopeptidases; Staurosporine; Substrate Specificity; Thrombin | 1993 |
Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Induction; Extracellular Matrix; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Naphthalenes; Oligodeoxyribonucleotides; Piperazines; Plasminogen Activator Inhibitor 1; Polycyclic Compounds; Protein Kinase C; RNA; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1993 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Receptor-evoked Ca2+ mobilization in pancreatic acinar cells: evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state.
Topics: Alkaloids; Animals; Brain; Calcium; Carbachol; Cholecystokinin; Fura-2; Inosine Triphosphate; Naphthalenes; Pancreas; Phosphorylation; Polycyclic Compounds; Proglumide; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C is a tonic negative regulator of steroidogenesis and steroid hydroxylase gene expression in Y1 adrenal cells and functions independently of protein kinase A.
Topics: 3-Hydroxysteroid Dehydrogenases; Adenosine Monophosphate; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Alkaloids; Animals; Bucladesine; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP-Dependent Protein Kinases; Enzyme Induction; Mice; Naphthalenes; Neoplasm Proteins; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Steroid 11-beta-Hydroxylase; Thionucleotides; Tumor Cells, Cultured | 1993 |
Effects of staurosporine and calphostin C, two structurally unrelated inhibitors of protein kinase C, on vascular tone.
Topics: Alkaloids; Animals; Aorta; Face; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rabbits; Sensitivity and Specificity; Staurosporine | 1993 |
Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antineoplastic Agents; Arachidonic Acid; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Mice; Naphthalenes; Piperazines; Protein Kinase C; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
The role of NF-kappaB in the angiogenic response of coronary microvessel endothelial cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Acetylcysteine; Alkaloids; Animals; Antioxidants; Base Sequence; Butylated Hydroxyanisole; Capillaries; Cell Nucleus; Cells, Cultured; Consensus Sequence; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kinetics; Microcirculation; Molecular Sequence Data; Naphthalenes; Neovascularization, Physiologic; NF-kappa B; Oligodeoxyribonucleotides; Protein Kinase C; Pyrrolidines; Rabbits; Staurosporine; Substrate Specificity; Thiocarbamates | 1996 |
Serine-1321-independent regulation of the mu 1 adult skeletal muscle Na+ channel by protein kinase C.
Topics: Adult; Alkaloids; Amino Acid Sequence; Base Sequence; Cell Line; Consensus Sequence; Conserved Sequence; DNA Primers; Enzyme Inhibitors; Ethers, Cyclic; Humans; Ion Channel Gating; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Multiple Sclerosis; Muscle, Skeletal; Mutagenesis, Site-Directed; Naphthalenes; Okadaic Acid; Phosphorylation; Polymerase Chain Reaction; Polyradiculoneuropathy; Protein Kinase C; Recombinant Proteins; Serine; Sodium Channels; Staurosporine; Transfection | 1995 |
Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth.
Topics: Alkaloids; Animals; Cattle; Cell Division; Cell Line; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Kidney Tubules, Proximal; Male; Mitogens; Naphthalenes; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Protein Kinase C; Proteins; Rabbits; Staurosporine; Swine; Teriparatide | 1995 |
Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase.
Topics: Alkaloids; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Inositol 1,4,5-Trisphosphate; Isoflavones; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Mice; Naphthalenes; Protein Kinase C; Protein Tyrosine Phosphatases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Urea | 1996 |
Modulation by protein kinase C activation of rat brain delayed-rectifier K+ channel expressed in Xenopus oocytes.
Topics: Alkaloids; Animals; Base Sequence; Brain; Cell Membrane; Diglycerides; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Female; Kinetics; Membrane Potentials; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Naphthalenes; Oocytes; Patch-Clamp Techniques; Potassium Channels; Protein Kinase C; Protein Structure, Secondary; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Xenopus laevis | 1996 |
Interleukin-1beta activates protein kinase C zeta in renal mesangial cells. Potential role in prostaglandin E2 up-regulation.
Topics: Alkaloids; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cytosol; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Interleukin-1; Kinetics; Male; Molecular Sequence Data; Naphthalenes; NF-kappa B; Oligonucleotide Probes; Oligonucleotides, Antisense; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1996 |
Amplitude-dependent modulation of brush border enzymes and proliferation by cyclic strain in human intestinal Caco-2 monolayers.
Topics: Alkaline Phosphatase; Alkaloids; Caco-2 Cells; Cell Count; Cell Division; Cell Size; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; Humans; Intestinal Mucosa; Microvilli; Mitomycins; Naphthalenes; Peristalsis; Protein Kinase C; Staurosporine; Stress, Mechanical; Thymidine | 1996 |
Protein kinase C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells.
Topics: Alkaloids; Calcium; Calcium-Transporting ATPases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Ionomycin; Ionophores; Lanthanum; Leukemia; Naphthalenes; Phorbol Esters; Protein Kinase C; Sodium; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1995 |
Selectivity of action of staurosporine on Ca2+ movements and contractions in vascular smooth muscles.
Topics: Alkaloids; Androstadienes; Animals; Calcium; Cerebral Arteries; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Naphthalenes; Potassium Chloride; Protein Kinase C; Rabbits; Staurosporine; Vasoconstriction; Wortmannin | 1995 |
Role of protein kinase C in the regulation of ATP-triggered intracellular Ca2+ oscillations in chicken granulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Chickens; Enzyme Activation; Female; Granulosa Cells; Intracellular Membranes; Naphthalenes; Osmolar Concentration; Protein Kinase C; Staurosporine | 1996 |
Acidic fibroblast factor induction of cyclooxygenase II in rabbit cardiac muscle microvessel endothelial cells: mediation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Blotting, Northern; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblast Growth Factor 1; Inositol Phosphates; Isoenzymes; Isoquinolines; Microcirculation; Myocardium; Naphthalenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Sulfonamides | 1994 |
Interactions between signaling pathways in mediating GnRH-stimulated GTH release from goldfish pituitary cells: protein kinase C, but not cyclic AMP is an important mediator of GnRH-stimulated gonadotropin secretion in goldfish.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Arachidonic Acid; Calcium Channel Agonists; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Male; Microspheres; Naphthalenes; Pituitary Gland; Potassium; Protein Kinase C; Salmon; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.
Topics: Animals; Calcium; Carcinogens; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine; Thiazoles; Vas Deferens | 1996 |
The potentiation of nitroglycerin-induced relaxation by PKG inhibition in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Potassium Channels; Protein Kinase C; Purinones; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes.
Topics: Acetates; Adipocytes; Animals; Benzoquinones; Cells, Cultured; Cinnamates; Deoxyglucose; Enzyme Inhibitors; Epididymis; Human Growth Hormone; Humans; Insulin; Kinetics; Lactams, Macrocyclic; Lipids; Lipolysis; Male; Naphthalenes; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyruvic Acid; Quinones; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Rifabutin; Staurosporine; Tyrphostins | 1996 |
Stimulation of inorganic phosphate transport by insulin-like growth factor I and vanadate in opossum kidney cells is mediated by distinct protein tyrosine phosphorylation processes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Cell Line; Enzyme Inhibitors; Epithelium; Genistein; Humans; Insulin; Insulin-Like Growth Factor I; Isoflavones; Kidney; Lactams, Macrocyclic; Naphthalenes; Oncogene Proteins; Opossums; Phosphates; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Signal Transduction; Sodium; Staurosporine; Vanadates | 1996 |
Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity.
Topics: Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Naphthalenes; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
The activation of phospholipase D participates in the mitogenic action of arginine vasopressin in cultured rat glomerular mesangial cells.
Topics: 2,3-Diphosphoglycerate; Animals; Arginine Vasopressin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Diphosphoglyceric Acids; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Glycerophospholipids; Male; Mitogens; Naphthalenes; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Involvement of protein kinase C in nerve growth factor- and K-252a-stimulated calcium uptake into PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Agonists; Carbazoles; Carcinogens; Enzyme Inhibitors; Indole Alkaloids; Indoles; Isoenzymes; Naphthalenes; Nerve Growth Factors; PC12 Cells; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Calcium; Carcinogens; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fetus; Gene Expression; Glutamic Acid; Kainic Acid; Membrane Proteins; N-Methylaspartate; Naphthalenes; Neurons; Phenanthridines; Potassium Chloride; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Prostaglandin F2alpha stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells.
Topics: Animals; Cell Line; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Interleukin-6; Mice; Naphthalenes; Osteoblasts; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Contribution of PKC to beta-hexosaminidase-induced airway smooth muscle proliferation.
Topics: Animals; beta-N-Acetylhexosaminidases; Cattle; Cell Count; Cell Division; Diacylglycerol Kinase; Enzyme Inhibitors; Hexosaminidase A; Insulin; Muscle, Smooth; Naphthalenes; Phenylisopropyladenosine; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Thymidine; Trachea | 1997 |
Evidence that protein kinase C is involved in delta-aminolevulinate synthase expression in rat hepatocytes.
Topics: 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Diglycerides; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Naphthalenes; Phenobarbital; Protein Kinase C; Rats; RNA, Messenger; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Protein kinase C activation by serotonin potentiates agonist-induced stimulation of cAMP production in cultured rat retinal pigment epithelial cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Isoproterenol; Naphthalenes; Phorbol 12,13-Dibutyrate; Pigment Epithelium of Eye; Protein Kinase C; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Staurosporine | 1997 |
The promoting effects of bFGF and astrocyte extracellular matrix on process outgrowth by adult human oligodendrocytes are mediated by protein kinase C.
Topics: Astrocytes; Cells, Cultured; Enzyme Inhibitors; Extracellular Matrix; Fibroblast Growth Factor 2; Humans; Naphthalenes; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine | 1997 |
Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase.
Topics: Adenoviruses, Human; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Humans; Indole Alkaloids; Indoles; Isoflavones; Isoquinolines; Lactoferrin; Low Density Lipoprotein Receptor-Related Protein-1; Maleimides; Melanoma; Naphthalenes; Phenols; Protein Kinase C; Receptors, Immunologic; Signal Transduction; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1997 |
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Genistein; Indomethacin; Isoflavones; Male; Naphthalenes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Polyenes; Rabbits; Staurosporine; Type C Phospholipases; Tyrosine | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents | 1997 |
A factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion.
Topics: Alkaloids; Animals; Benzophenanthridines; Binding Sites; Cell Line; Cysteine; Endosomes; Enzyme Inhibitors; Isoenzymes; Kinetics; Macrophages; Membrane Fusion; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Recombinant Fusion Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1997 |
Preconditioning of isolated rabbit cardiomyocytes: no evident separation of induction, memory and protection.
Topics: Adenosine; Alkaloids; Animals; Benzophenanthridines; Cardiovascular Agents; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Heart; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardium; Naphthalenes; Phenanthridines; Protein Kinase C; Rabbits; Staurosporine | 1997 |
Opposite regulation of adenylyl cyclase by protein kinase C in astrocyte and microglia cultures.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Astrocytes; Cell Membrane; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cytosol; Enzyme Inhibitors; Homeostasis; Isoproterenol; Kinetics; Microglia; Naphthalenes; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs.
Topics: Alkaloids; Animals; Benzophenanthridines; Carcinogens; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Hormone; Growth Hormone-Releasing Hormone; Isoquinolines; Naphthalenes; Oligopeptides; Phenanthridines; Pituitary Gland; Protein Kinase C; Second Messenger Systems; Sheep; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Dinoprostone; Endocannabinoids; Enzyme Activation; Ethanolamines; Genistein; GTP-Binding Proteins; Linoleic Acids; Macrophages; Mice; Naphthalenes; Neuroblastoma; Nitriles; Palmitic Acids; Phospholipases A; Polyunsaturated Alkamides; Second Messenger Systems; Staurosporine; Tumor Cells, Cultured; Tyrphostins; Virulence Factors, Bordetella | 1997 |
Protein kinase C activation by interleukin (IL)-1 limits IL-1-induced IL-6 synthesis in osteoblast-like cells: involvement of phosphatidylcholine-specific phospholipase C.
Topics: Animals; Bridged-Ring Compounds; Cell Line; Choline; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Inositol Phosphates; Interleukin-1; Interleukin-6; Mice; Naphthalenes; Norbornanes; Osteoblasts; Protein Kinase C; Staurosporine; Thiocarbamates; Thiones; Type C Phospholipases | 1997 |
Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscle.
Topics: Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Membrane Permeability; Cytosol; Diglycerides; Dogs; Enzyme Inhibitors; Escin; Female; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Trachea | 1997 |
Cyclic strain stimulates isoform-specific PKC activation and translocation in cultured human keratinocytes.
Topics: Biological Transport; Cell Division; Cell Membrane; Cell Size; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Keratinocytes; Naphthalenes; Phenotype; Protein Kinase C; Signal Transduction; Staurosporine; Stress, Mechanical | 1997 |
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells.
Topics: Aldosterone; Animals; Anti-Bacterial Agents; Cell Line; Dogs; Enzyme Inhibitors; Hydrogen-Ion Concentration; Imidazoles; Kidney; Kinetics; Macrolides; Meglumine; Membrane Potentials; Naphthalenes; Pertussis Toxin; Protein Kinase C; Protein Serine-Threonine Kinases; Proton Pump Inhibitors; Proton-Translocating ATPases; Sodium-Hydrogen Exchangers; Spironolactone; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Zinc | 1997 |
Role of cAMP and calcium influx in endothelin-1-induced ANP release in rat cardiomyocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzophenanthridines; Calcium; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhibitors; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Epoprostenol; Heart; Heart Ventricles; Kinetics; Myocardium; Naphthalenes; Nifedipine; Phenanthridines; Protein Kinase C; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Staurosporine; Thionucleotides | 1997 |
Basic fibroblast growth factor induces interleukin-6 synthesis in osteoblasts: autoregulation by protein kinase C.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Gallic Acid; Interleukin-6; Mice; Naphthalenes; Osteoblasts; Phosphodiesterase Inhibitors; Phospholipase D; Propranolol; Protein Kinase C; Pyrrolidinones; Skull; Staurosporine; Sympatholytics; Type C Phospholipases | 1997 |
Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Cromakalim; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Inhibitors; Glyburide; Guanosine Diphosphate; Hypoglycemic Agents; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Naphthalenes; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation.
Topics: Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Flavonoids; Gene Expression Regulation; Humans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Polymerase Chain Reaction; Protein Kinase C; Receptors, LDL; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Suppression of GnRH gene expression in GT1-1 hypothalamic neuronal cells: action of protein kinase C.
Topics: Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Gonadotropin-Releasing Hormone; Hypothalamus; Isoenzymes; Luciferases; Mice; Naphthalenes; Neurons; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-fos; Recombinant Fusion Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1997 |
Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid.
Topics: Adrenal Glands; Animals; Calcium; Carbachol; Catecholamines; Cattle; Chromaffin Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Genistein; Lysophospholipids; Naphthalenes; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sodium; Sodium-Calcium Exchanger; Staurosporine; Structure-Activity Relationship; Suramin; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
Mitogen-activated protein kinase is activated during IgG-mediated phagocytosis, but is not required for target ingestion.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoglobulin G; Mitogen-Activated Protein Kinase 1; Monocytes; Naphthalenes; Phagocytosis; Phospholipases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, IgG; Staurosporine | 1998 |
Increases in acetylcholine release produced by phorbol esters are not mediated by protein kinase C at motor nerve endings.
Topics: Acetylcholine; Animals; Carcinogens; Enzyme Inhibitors; Naphthalenes; Neuromuscular Junction; Phorbol Esters; Protein Kinase C; Rana pipiens; Sphingosine; Staurosporine | 1998 |
Novel protein kinase C, nPKC, inhibition of murine bumetanide-sensitive Na+,K+,2Cl- cotransporter BSC1 in Xenopus oocyte.
Topics: Animals; Bumetanide; Carrier Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Gene Transfer Techniques; Mice; Naphthalenes; Oocytes; Protein Kinase C; Recombinant Proteins; Rubidium; Sodium-Potassium-Chloride Symporters; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus | 1998 |
High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cattle; Cell Communication; Cells, Cultured; Connexin 43; Dose-Response Relationship, Drug; Enzyme Activation; Gap Junctions; Glucose; Mannitol; Muscle, Smooth, Vascular; Naphthalenes; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Staurosporine-induced versus spontaneous squamous metaplasia in pre- and postmenopausal breast tissue.
Topics: Adult; Aged; Anticarcinogenic Agents; Breast; Breast Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Keratin-10; Keratinocytes; Keratins; Middle Aged; Naphthalenes; Postmenopause; Premenopause; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Up-Regulation | 1998 |
Interactions of signaling pathways in ACTH (1-24)-induced cell shape changes in invertebrate immunocytes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Bivalvia; Cell Size; Cosyntropin; Dideoxyadenosine; Enzyme Inhibitors; GTP-Binding Proteins; Hemocytes; Hemolymph; Image Processing, Computer-Assisted; Isoquinolines; Microscopy, Phase-Contrast; Naphthalenes; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Sulfonamides; Suramin | 1998 |
Modulation of human CACO-2 intestinal epithelial cell phenotype by protein kinase C inhibitors.
Topics: Caco-2 Cells; Cell Division; Cell Movement; Collagen; Enzyme Inhibitors; Humans; Microvilli; Mitomycin; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phenotype; Protein Kinase C; Staurosporine | 1995 |
A role of myofilament Ca2+ sensitivity in enhanced vascular reactivity in cardiomyopathic hamsters.
Topics: Actin Cytoskeleton; Angiotensin II; Animals; Aorta; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cricetinae; Indoles; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nifedipine; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium; Ryanodine; Staurosporine; Vasoconstrictor Agents | 1998 |
Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure.
Topics: Animals; Aphidicolin; Cell Death; Cycloheximide; Dactinomycin; DNA Damage; DNA Repair; Enzyme Inhibitors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Genistein; Growth Substances; Humans; Hydrogen Peroxide; Kinetics; Lung Neoplasms; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Pulmonary Alveoli; Rats; Staurosporine; Tumor Cells, Cultured | 1998 |
Activation of H+-ATPase by hypotonicity: a novel regulatory mechanism for H+ secretion in IMCD cells.
Topics: Ammonium Chloride; Animals; Cell Line; Cells, Cultured; Enzyme Activation; Fluoresceins; Hydrogen-Ion Concentration; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Naphthalenes; Osmolar Concentration; Protein Kinase C; Proton-Translocating ATPases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium | 1998 |
Effects of genistein and staurosporine on angiotensin II-induced DNA synthesis, protein synthesis and mitogen-activated protein kinase activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Male; Muscle Proteins; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1998 |
Differential effects of protein kinase C inhibitors on fibronectin-induced interleukin-beta gene transcription, protein synthesis and secretion in human monocytic cells.
Topics: Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Inhibitors; Fibronectins; Gene Expression; Humans; Interleukin-1; Leukocytes, Mononuclear; Naphthalenes; Precipitin Tests; Protein Kinase C; Staurosporine; Transcription Factor AP-1; Transcription, Genetic; U937 Cells | 1998 |
PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzophenanthridines; Benzoquinones; Brain; Carcinogens; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lactams, Macrocyclic; Microglia; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C.
Topics: Blood Proteins; Cell Degranulation; Complement C5a; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Eosinophil Granule Proteins; Eosinophils; Humans; Naphthalenes; Platelet Activating Factor; Protein Kinase C; Ribonucleases; Staurosporine; Time Factors | 1998 |
Calphostin C induces expression of amphiregulin mRNA via reactive oxygen species in IEC-6 cells.
Topics: Acetylcysteine; Amphiregulin; Animals; Cell Line; Drug Interactions; EGF Family of Proteins; Enzyme Inhibitors; Epithelial Cells; Free Radical Scavengers; Glycoproteins; Growth Substances; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Intestines; Naphthalenes; Rats; Reactive Oxygen Species; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitization of smooth muscle of rabbit mesenteric artery.
Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Carcinogens; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; rho GTP-Binding Proteins; Ribose; Staurosporine; Tyrosine; Tyrphostins; Vasoconstrictor Agents | 1998 |
The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta.
Topics: Calcium; Cell Division; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Isoenzymes; Lymphokines; Microscopy, Confocal; Naphthalenes; Oligodeoxyribonucleotides, Antisense; Pertussis Toxin; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Staurosporine; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Virulence Factors, Bordetella | 1999 |
Tonic regulation of excitation-contraction coupling by basal protein kinase C activity in isolated cardiac myocytes.
Topics: Animals; Caffeine; Calcium-Transporting ATPases; Contractile Proteins; Enzyme Inhibitors; Heart; In Vitro Techniques; Kinetics; Magnesium; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Naphthalenes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sarcolemma; Sarcoplasmic Reticulum; Staurosporine; Time Factors | 1998 |
p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells.
Topics: Alkaloids; alpha Catenin; Benzoquinones; beta Catenin; Binding Sites; Cadherins; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cytoskeletal Proteins; Delta Catenin; DNA Primers; DNA, Complementary; Electrophoresis; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genistein; HT29 Cells; Humans; Kidney; Lactams, Macrocyclic; Membrane Glycoproteins; Mucin-1; Naphthalenes; Phosphoproteins; Quinones; Rifabutin; Staurosporine; Trans-Activators; Transfection | 1999 |
Hyperglycemia increases vascular adrenomedullin expression.
Topics: Adrenomedullin; Amino Acid Sequence; Animals; Aorta; Diabetic Angiopathies; Hyperglycemia; Male; Muscle, Smooth, Vascular; Naphthalenes; Peptides; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine | 1999 |
Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by bisindolylmaleimide I, a "selective" protein kinase C inhibitor.
Topics: Alkaloids; Animals; Benzophenanthridines; Binding, Competitive; Cell Membrane; DNA; Enzyme Inhibitors; In Vitro Techniques; Indoles; Maleimides; Mice; Naphthalenes; Oocytes; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; RNA; Serotonin Antagonists; Staurosporine; Xenopus laevis | 1999 |
Mechanical stretch induces platelet-activating factor receptor gene expression through the NF-kappaB transcription factor.
Topics: Animals; Base Sequence; Cattle; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation; Molecular Sequence Data; Muscle, Smooth, Vascular; Naphthalenes; NF-kappa B; NF-kappa B p50 Subunit; Nucleic Acid Synthesis Inhibitors; Physical Stimulation; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine | 1999 |
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates | 1999 |
Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibition.
Topics: Animals; Calcium; Enzyme Inhibitors; Female; Hypertension; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy, Animal; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Vascular Resistance | 1999 |
Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis.
Topics: Apoptosis; Calcimycin; Cell Death; Cell Survival; Cycloheximide; Dactinomycin; DNA, Antisense; Gene Expression Regulation, Enzymologic; Humans; Naphthalenes; RNA, Antisense; Staurosporine; Transcription, Genetic; Transfection; Transglutaminases; Tretinoin; Tumor Cells, Cultured | 1999 |
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine | 1999 |
Nitric oxide activates PKCalpha and inhibits Na+-K+-ATPase in opossum kidney cells.
Topics: Alkaloids; Animals; Arachidonic Acids; Carbazoles; Cell Line; Enzyme Activation; Enzyme Inhibitors; Estrenes; Indoles; Isoenzymes; Kidney; Kidney Tubules, Proximal; Kinetics; Naphthalenes; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Opossums; Protein Kinase C; Protein Kinase C-alpha; Pyrrolidinones; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow.
Topics: Adult; Antigens, CD; Antigens, CD34; Bone Marrow Cells; Cell Differentiation; Cell Nucleus; Cells, Cultured; Enzyme Inhibitors; Erythropoietin; Gene Expression Regulation, Enzymologic; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Isoenzymes; Naphthalenes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Recombinant Proteins; Staurosporine; Stem Cell Factor; Tetradecanoylphorbol Acetate | 2000 |
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indoles; Interneurons; Isoxazoles; Kainic Acid; Lidocaine; Maleimides; Naphthalenes; Nerve Tissue Proteins; Patch-Clamp Techniques; Propionates; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 2000 |
Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils.
Topics: Acetophenones; Antigens, CD; Benzopyrans; Cells, Cultured; Chemotactic Factors; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dipeptides; Down-Regulation; Humans; Hydroxamic Acids; L-Selectin; Metalloendopeptidases; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.
Topics: Animals; Biological Transport; Calcium; Carcinogens; Cyclic GMP; Dogs; Enzyme Inhibitors; Female; Femoral Artery; Fluorescent Dyes; Free Radical Scavengers; Fura-2; Hypoglycemic Agents; Insulin; Male; Manganese; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase C; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction | 2000 |
Activation of TxA2/PGH2 receptors and protein kinase C contribute to coronary dysfunction in superoxide treated rat hearts.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium Channel Blockers; Cardiovascular Agents; Coronary Disease; Dinoprost; Enzyme Inhibitors; In Vitro Techniques; Indomethacin; Male; Methacrylates; Naphthalenes; Perfusion; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Staurosporine; Superoxides; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents | 2000 |
Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells.
Topics: Animals; Biological Transport; Calcium; Cell Line; Cell Membrane; Diglycerides; Enzyme Inhibitors; Green Fluorescent Proteins; Intracellular Membranes; Isoenzymes; Luminescent Proteins; Macrophages; Mice; Naphthalenes; Phagocytosis; Phagosomes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Respiratory Burst; Staurosporine | 2000 |
Hydrogen peroxide attenuates store-operated calcium entry and enhances calcium extrusion in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Barium; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Line; Down-Regulation; Enzyme Activation; Hydrogen Peroxide; Isoenzymes; Manganese; Membrane Potentials; Mercaptoethanol; Naphthalenes; Oxidation-Reduction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Rats; Sodium; Staurosporine; Thapsigargin; Thyroid Gland | 2000 |
Dual role of PKC in modulating pharmacomechanical coupling in fetal and adult cerebral arteries.
Topics: Animals; Cell Membrane; Cerebral Arteries; Enzyme Inhibitors; Feedback; Fetus; Indoles; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Lactams; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Sheep; Signal Transduction; Staurosporine; Vasoconstriction | 2000 |
Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arsenicals; Enzyme Inhibitors; Female; Naphthalenes; Phospholipases A; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetramisole; Tyrosine | 2000 |
Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
Topics: Bridged-Ring Compounds; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Naphthalenes; NF-kappaB-Inducing Kinase; Norbornanes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Thiocarbamates; Thiones; Tyrphostins | 2000 |
Modulation of alveolar macrophage phagocytosis by leukotrienes is Fc receptor-mediated and protein kinase C-dependent.
Topics: Acetophenones; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Female; Hydroxyurea; Immune Sera; Immunoglobulin G; Klebsiella pneumoniae; Leukotriene Antagonists; Leukotrienes; Macrophages, Alveolar; Microspheres; Naphthalenes; Phagocytosis; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Fc; Receptors, Leukotriene B4; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Tetrazoles | 2000 |
Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway.
Topics: Animals; Blotting, Western; Carrier Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Lectins; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Receptors, Cell Surface; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; U937 Cells | 2001 |
Pertussis toxin-sensitive G-protein and protein kinase C activity are involved in normal synapse elimination in the neonatal rat muscle.
Topics: Animals; Animals, Newborn; Enzyme Inhibitors; GTP-Binding Proteins; Hemostatics; Male; Motor Neurons; Muscle Development; Muscle, Skeletal; Naphthalenes; Neuromuscular Junction; Pertussis Toxin; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Staurosporine; Thrombin; Virulence Factors, Bordetella | 2001 |
Use of protein kinase C inhibitors results in rapid [Mg(2+)](i) mobilization in primary cultured rat aortic smooth muscle cells: are certain kinase C isoforms natural homeostatic regulators of cystolic free Mg(2+).
Topics: Alkaloids; Animals; Aorta; Benzophenanthridines; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Indoles; Magnesium; Maleimides; Muscle, Smooth, Vascular; Naphthalenes; Phenanthridines; Protein Isoforms; Protein Kinase C; Rats; Staurosporine | 2001 |
Effect of protein kinase C inhibition on hypoxic pulmonary vasoconstriction.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Dogs; Enzyme Inhibitors; Female; Hypoxia; In Vitro Techniques; Indoles; Male; Naphthalenes; Perfusion; Phorbol Esters; Protein Kinase C; Pulmonary Circulation; Staurosporine; Vascular Resistance; Vasoconstriction | 2001 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.
Topics: Animals; Antiprotozoal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Binding Sites; Cytosol; Daunorubicin; Drug Resistance, Multiple; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Fungal Proteins; Leishmania tropica; Membrane Proteins; Mice; Naphthalenes; Protein Kinase C; Protein Structure, Tertiary; Protozoan Proteins; Pyrophosphatases; Rhodamines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Staurosporine | 2001 |
Mechanism of prostaglandin D(2)-stimulated heat shock protein 27 induction in osteoblasts.
Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin D2; Pyridines; RNA, Messenger; Staurosporine | 2001 |
Role of Ca2+-sensitive protein kinase C in phenylephrine enhancement of Ca2+ sensitivity in rat tail artery.
Topics: Animals; Arteries; Caffeine; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Male; Mesylates; Naphthalenes; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Staurosporine; Tail; Vasoconstrictor Agents | 2001 |
Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells.
Topics: Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Inhibitory Concentration 50; Interphase; Maleimides; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Naphthalenes; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Staurosporine; Transcription Factors; Tretinoin | 2001 |
Involvement of PKC and NF-kappaB in nitric oxide induced apoptosis in human coronary artery smooth muscle cells.
Topics: Apoptosis; Cell Nucleus; Cells, Cultured; Coronary Vessels; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Humans; I-kappa B Proteins; Molsidomine; Muscle, Smooth, Vascular; Naphthalenes; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Kinase C; Staurosporine; Tumor Suppressor Protein p53 | 2001 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
Effect of protein kinase C on endoplasmic reticulum cholesterol.
Topics: Acetophenones; Benzopyrans; Bryostatins; Calcium; Cell Membrane; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Inhibitors; Fibroblasts; Humans; Lactones; Macrolides; Mitogens; Naphthalenes; Protein Isoforms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
Topics: Analysis of Variance; Animals; Butadienes; Calcium; Calcium Channel Blockers; Cell Line; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Chaperones; Naphthalenes; Neoplasm Proteins; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Staurosporine; Stimulation, Chemical; Time Factors; Type C Phospholipases | 2002 |
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.
Topics: Adult; Antigens, CD34; Antigens, Differentiation; Butadienes; Carbazoles; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Flavonoids; Glycophorins; Hematopoietic Stem Cells; Humans; Indoles; Isoenzymes; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Staurosporine; Stem Cell Factor | 2002 |
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells.
Topics: Acetophenones; Animals; Benzopyrans; Calcium; Carbazoles; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation; Indoles; Isoenzymes; Maleimides; Naphthalenes; Phorbol Esters; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Staurosporine; Thyrotropin-Releasing Hormone; Transcription, Genetic | 2002 |
Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carbazoles; Cell Membrane; Culture Techniques; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Indoles; Naphthalenes; Ovariectomy; Phosphorylation; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Staurosporine | 2002 |
Protein kinase antagonists inhibit invasion of mammalian cells by Fonsecaea pedrosoi.
Topics: Animals; Cell Adhesion; CHO Cells; Cricetinae; Drug Interactions; Enzyme Inhibitors; Fungi; Genistein; Naphthalenes; Okadaic Acid; Protein Kinase Inhibitors; Staurosporine | 2003 |
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element
Topics: Antioxidants; Binding Sites; Blotting, Western; Cell Line; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression; Humans; Immunosorbent Techniques; Leucine Zippers; Mutagenesis, Site-Directed; NAD(P)H Dehydrogenase (Quinone); Naphthalenes; NF-E2-Related Factor 2; Phosphorylation; Protein Kinase C; Response Elements; Serine; Staurosporine; Structure-Activity Relationship; Trans-Activators; Transcription, Genetic; Transfection | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2003 |
Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction.
Topics: Amino Acid Sequence; Animals; Cytosol; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Green Fluorescent Proteins; Hydrolysis; Luminescent Proteins; Microscopy, Confocal; Molecular Sequence Data; Mutagenesis; Naphthalenes; Oocytes; Osmosis; Phosphatidylinositol 4,5-Diphosphate; Point Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Rabbits; RNA, Complementary; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Xenopus; Xenopus laevis | 2004 |
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cryptococcus neoformans; Diglycerides; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genistein; Isoenzymes; Laccase; Molecular Sequence Data; Naphthalenes; Oligodeoxyribonucleotides, Antisense; Protein Kinase C; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid; Sphingolipids; Staurosporine | 2004 |
Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L.).
Topics: Amiloride; Animals; Bivalvia; Cadmium; Digestive System; Epinephrine; Greece; Hydrogen-Ion Concentration; Isoproterenol; Naphthalenes; Phenylephrine; Phorbol Esters; Prazosin; Propranolol; Protein Kinase C; Pyruvate Kinase; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine | 2004 |
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
Topics: Amphiregulin; Androstadienes; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Line, Tumor; Culture Media, Serum-Free; EGF Family of Proteins; Enzyme Inhibitors; Flavonoids; Glycoproteins; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Models, Biological; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Wortmannin | 2005 |
Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells.
Topics: Animals; Apoptosis; beta Catenin; Bone and Bones; Bone Development; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Enzyme Inhibitors; Etoposide; Gene Expression Regulation; Isoquinolines; Lithium Chloride; Luciferases; Mice; Naphthalenes; NIH 3T3 Cells; Osteoblasts; Parathyroid Hormone; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad3 Protein; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Transforming Growth Factor beta | 2006 |
Golgi complex disassembly caused by light-activated calphostin C involves MAPK and PKA.
Topics: Cyclic AMP-Dependent Protein Kinases; Endocytosis; Flavonoids; Fluorescent Antibody Technique; Golgi Apparatus; Horseradish Peroxidase; HT29 Cells; Humans; Isoquinolines; Light; Mitogen-Activated Protein Kinases; Naphthalenes; Staurosporine; Sulfonamides | 2007 |
Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.
Topics: Animals; Carcinogens; Cells, Cultured; Dimerization; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hepatocyte Nuclear Factor 1-beta; Humans; Inflammation; MafG Transcription Factor; Male; Mutation; Naphthalenes; Nitric Oxide Synthase Type II; Protein Kinase C; Rats; Rats, Sprague-Dawley; Repressor Proteins; Response Elements; RNA, Small Interfering; Signal Transduction; Smad6 Protein; Smad7 Protein; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2007 |
Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Deoxyglucose; Electric Stimulation; Enzyme Activation; Glucose; Glucose Transporter Type 4; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Multienzyme Complexes; Muscle Contraction; Myocytes, Cardiac; Naphthalenes; Oligomycins; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Troponin I | 2008 |
Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C.
Topics: Benzophenanthridines; Cell Line, Tumor; Enzyme Inhibitors; Humans; Naphthalenes; Neoplasm Invasiveness; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin | 1997 |
Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Humans; In Situ Hybridization; Male; Naphthalenes; NAV1.3 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X; Sodium Channels; Staurosporine | 2011 |