staurosporine has been researched along with tyrosine in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.99) | 18.7374 |
| 1990's | 68 (67.33) | 18.2507 |
| 2000's | 29 (28.71) | 29.6817 |
| 2010's | 2 (1.98) | 24.3611 |
| 2020's | 1 (0.99) | 2.80 |
| Authors | Studies |
|---|---|
| Decker, SJ; Ohmichi, M; Pang, L; Saltiel, AR | 1 |
| Kume, S; Ozaki, Y; Yatomi, Y | 1 |
| Anderson, NG | 1 |
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Donnenberg, MS; Finlay, BB; Kaper, JB; Rosenshine, I | 1 |
| Burroughs, S; Feinstein, MB; Huang, CK; Lau, LF; Pumiglia, KM | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI; Wang, E; Yamazaki, M | 1 |
| Berkow, RL | 1 |
| Beck, KD; Burton, LE; Hefti, F; Kaplan, DR; Knüsel, B; Nikolics, K; Rabin, S; Rosenthal, A; Winslow, JW | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Cleaveland, JS; Hammond, DJ; Kiener, PA; Schacter, BZ | 1 |
| Avruch, J; Bonventre, JV; Force, T; Kyriakis, JM | 1 |
| Abraham, RT; Augustine, JA; Daniels, JK; Leibson, PJ; Secrist, JP | 1 |
| Furuya, W; Grinstein, S | 1 |
| Kolp, R; Lamb, RJ; Modiano, JF; Nowell, PC | 1 |
| Abraham, RT; Karnitz, L; Secrist, JP | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Gamou, S; Shimizu, N | 1 |
| Barger, SW; Cheng, B; Mattson, MP | 1 |
| Danaher, M; Fallon, RJ; Saxena, A; Saylors, RL | 1 |
| Wallace, BG | 1 |
| Yang, SD; Yu, JS | 1 |
| Fallon, RJ; Perlmutter, DH; Sippel, CJ | 1 |
| Herberman, RB; Lin, WC; Rabinowich, H; Whiteside, TL | 1 |
| Golde, DW; Lacomis, L; Nichols, GL; Raines, MA; Tempst, P; Vera, JC | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Ihara, Y; Kanayama, Y; Matsuzawa, Y; Nishikawa, A; Nishiura, T; Taniguchi, N; Yoshimura, M | 1 |
| Bradshaw, RA; Raffioni, S | 1 |
| Chang, NS | 1 |
| Fujimura, Y; Kume, S; Miura, S; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Corvaia, N; Coutant, KD; Ryder, NS | 1 |
| Soltoff, SP; Toker, A | 1 |
| Mire-Sluis, A; Page, LA; Thorpe, R; Wadhwa, M | 1 |
| Cutler, RL; Krystal, G; Liu, L | 1 |
| Feinstein, R; Hemi, R; Kanety, H; Karasik, A; Papa, MZ | 1 |
| Chen, F; Demers, LM; Gaydos, LJ; Kuhn, DC; Sun, SC | 1 |
| Kaur, G; Sausville, EA; Sebers, S; Seynaeve, CM; Stetler-Stevenson, M; Worland, PJ | 1 |
| Abraham, I; McCroskey, MC; Sampson, KE | 1 |
| Breu, J; Petryniak, MA; Slack, BE; Srivastava, K; Wurtman, RJ | 1 |
| Collaco, C; Doan, R; Dyer, RB; Herzog, NK; Niesel, DW | 1 |
| Lazarovici, P; Rasouly, D | 1 |
| Vietor, I; Vilcek, J | 1 |
| Gouilleux, F; Groner, B; Mundt, M; Wakao, H | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Jalava, A; Mai, S | 1 |
| Dangelmaier, C; Daniel, JL; Smith, JB | 1 |
| Asselin, J; Blake, RA; Walker, T; Watson, SP | 1 |
| Hordijk, PL; Moolenaar, WH; van Corven, EJ; Verlaan, I | 1 |
| Kume, S; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Bhatia, M; Kirkland, JB; Meckling-Gill, KA | 1 |
| Cossins, AR; Weaver, YR | 1 |
| Auberger, P; Baeuerle, PA; Farahifar, D; Imbert, V; Livolsi, A; Mueller-Dieckmann, C; Pahl, HL; Peyron, JF; Rossi, B; Rupec, RA; Traenckner, EB | 1 |
| Elejalde, RB; Lazarovici, P; Lelkes, PI; Rasouly, D; Shavit, D; Unsworth, BR; Yayon, A; Zuniga, R | 1 |
| Madianos, PN; Papapanou, PN; Sandros, J | 1 |
| Albero, D; Bardelli, A; Comoglio, PM; Goruppi, S; Longati, P; Ponzetto, C; Schneider, C | 1 |
| Londos, C; Rondinone, CM; Smith, UP; Zarnowski, MJ | 1 |
| Huber, M; Kandolf, R; Selinka, HC | 1 |
| Colamonici, OR; Krolewski, JJ; Platanias, LC; Sweet, M; Uddin, S | 1 |
| Murai, A; Nakahata, N; Nakamura, H; Ohizumi, Y; Rho, MC | 1 |
| Houghton, PJ; Luo, W; Sharif, M; Sharif, TR | 1 |
| Carlini, CR; Francischetti, IM; Ghazaleh, FA; Guimarães, JA; Reis, RA | 1 |
| de Boland, AR; Norman, AW | 1 |
| Balduini, C; Brovelli, A; Ciana, A; Low, PS; Minetti, G; Seppi, C | 1 |
| Chiltz, A; Lebrun-Garcia, A; Ouaked, F; Pugin, A | 1 |
| Bradford, MD; Soltoff, SP | 1 |
| Ott, VL; Rapraeger, AC | 1 |
| Hattori, Y; Kanno, M; Kitabatake, A; Kohya, T; Moriishi, K; Oguma, K; Sasaki, M; Tomita, F | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Akinaga, S; Akiyama, T; Okabe, M; Shimizu, M; Tamaoki, T | 1 |
| Akeda, Y; Cantarelli, VV; Honda, T; Nagayama, K; Takahashi, A | 1 |
| Appleyard, SM; Chavkin, C; Pattillo, A; Rogalski, SL; Terman, GW | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Hatem, SN; Henaff, M; Mercadier, JJ | 1 |
| Haller, H; Kettritz, R; Luft, FC; Schreiber, A | 1 |
| Feldman, RD; Ferguson, SS; Kelvin, DJ; Litchfield, DW; Tan, CM | 1 |
| Knaggs, AR | 1 |
| Bijur, GN; Jope, RS | 1 |
| Gavenis, K; Meyer, T; Vinkemeier, U | 1 |
| Fuhrer, C; Marangi, PA; Wieland, ST | 1 |
| Jin, T; Li, J | 1 |
| Kabir, J; Lobo, M; Zachary, I | 1 |
| Kitani, S; Morita, Y; Nakamura, R; Sasaki, N; Sato, Y; Sawada, J; Teshima, R | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Cohen, P; Cole, A; Frame, S | 1 |
| Capodici, J; Karikó, K; Lamphier, M; Ni, H; Weissman, D | 1 |
| Aitken, RJ; Baker, MA; Gunasekera, T; Hetherington, L; Mate, KE; Rodger, JC; Sidhu, KS; Veal, D | 1 |
| Biswas, D; Itoh, K; Niwa, H | 1 |
| Collett, VJ; Collingridge, GL | 1 |
| Babine, RE; Cantin, SM; Gorga, JC; Jin, L; Pandey, P; Petrella, EC; Pluskey, S; Rynkiewicz, MJ; Seidl, KJ; Strickler, JE; Weaver, DT | 1 |
| Avraham, H; Melendez, J; Schaefer, E; Steinberg, SF; Sussman, MA; Turner, C | 1 |
| Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD | 1 |
| Jebe, E; Petrunkina, AM; Töpfer-Petersen, E | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Chang, NS; Doherty, J; Ensign, A; Hong, Q; Hsu, LJ; Schultz, L | 1 |
| Bagrintseva, K; Ellwart, JW; Hiddemann, W; Hopfner, KP; Reindl, C; Schnittger, S; Spiekermann, K; Vempati, S; Wenig, K | 1 |
| Cho, KA; Oh, YS; Park, SC; Ryu, SJ | 1 |
| Catley, L; Fabbro, D; Griffin, JD; Hall-Meyers, E; Jiang, J; Kung, AL; Manley, PW; Moreno, D; Podar, K; Ray, A; Weisberg, E; Wright, RD | 1 |
| Barnett, J; Bradshaw, JM; Dinh, M; Grunberger, D; Hill, RJ; Ho, H; Lee, S; Shaw, D; Swinney, DC; Tsing, SY | 1 |
| Adamia, S; Barrett, R; Daley, JF; Fox, E; Frank, D; Griffin, JD; Nelson, E; Ray, A; Sattler, M; Weisberg, E; Zhang, C | 1 |
| Åberg, E; Alexeeva, M; Engh, RA; Rothweiler, U | 1 |
| He, H; Lane, NE; Lei, G; Li, J; Wang, Y; Wei, J; Wu, J; Yang, T; Zeng, C; Zhang, Y | 1 |
1 review(s) available for staurosporine and tyrosine
| Article | Year |
|---|---|
The biosynthesis of shikimate metabolites.
Topics: 3-Deoxy-7-Phosphoheptulonate Synthase; 3-Phosphoshikimate 1-Carboxyvinyltransferase; Alkyl and Aryl Transferases; Animals; Anthranilate Synthase; Bacteria; Betalains; Catalysis; Chorismate Mutase; Coumarins; Flavonoids; Hydro-Lyases; Indoleacetic Acids; Indoles; Intramolecular Transferases; Lignans; Molecular Structure; Penicillium; Phenylalanine; Phenylpropionates; Phosphorus-Oxygen Lyases; Prephenate Dehydratase; Prephenate Dehydrogenase; Pristinamycin; Pyrrolnitrin; Quaternary Ammonium Compounds; Quinones; Shikimic Acid; Staurosporine; Tannins; Thiazoles; Thyroxine; Tryptophan; Tyrosine; Ubiquinone | 2001 |
100 other study(ies) available for staurosporine and tyrosine
| Article | Year |
|---|---|
Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase.
Topics: Alkaloids; Carbazoles; Cell Line, Transformed; Humans; Indole Alkaloids; Nerve Growth Factors; Oncogene Proteins; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Synthesis of phosphatidylinositol 3,4-bisphosphate but not phosphatidylinositol 3,4,5-trisphosphate is closely correlated with protein-tyrosine phosphorylation in thrombin-activated human platelets.
Topics: Alkaloids; Blood Platelets; Bucladesine; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphates; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorus Radioisotopes; Phosphorylation; Platelet Activation; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Thrombin; Tyrosine | 1992 |
Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes.
Topics: 3T3 Cells; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Growth Hormone; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tyrosine | 1992 |
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake.
Topics: Alkaloids; Cell Membrane; Cytoskeleton; Epithelium; Escherichia coli; Genes, Bacterial; Genetic Complementation Test; Genistein; HeLa Cells; Humans; Isoflavones; Kinetics; Models, Biological; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tyrosine | 1992 |
Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).
Topics: Actins; Adenosine Triphosphate; Alkaloids; Blood Proteins; Blotting, Western; Calcium; Catechols; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Nitriles; Phospholipids; Phosphoproteins; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Tyrosine Phosphatases; Serotonin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine; Tyrphostins; Vanadates | 1992 |
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Granulocyte-macrophage colony-stimulating factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins.
Topics: Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Indole Alkaloids; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurons, Afferent; Neurotrophin 3; Pheochromocytoma; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Rats; Receptor, trkA; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1992 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
A microtiter-based assay for the detection of protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaloids; Antibodies; Autoanalysis; Binding, Competitive; Carbazoles; Enzyme Stability; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Indole Alkaloids; Muramidase; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 1990 |
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.
Topics: Alkaloids; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endothelins; Glomerular Mesangium; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Substrate Specificity; Tyrosine; Vasopressins | 1991 |
Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism.
Topics: Alkaloids; Calcium; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
Protein kinase C regulates both production and secretion of interleukin 2.
Topics: Alkaloids; Blotting, Northern; Blotting, Western; Flow Cytometry; Gene Expression Regulation, Enzymologic; Humans; Interleukin-2; Mitogens; Phosphorylation; Protein Kinase C; Receptors, Interleukin-2; RNA; Staurosporine; T-Lymphocytes; Transcription, Genetic; Tyrosine | 1991 |
T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1.
Topics: Alkaloids; Blotting, Western; Humans; Hydrolysis; Inositol Phosphates; Leukemia; Phosphorylation; Receptors, Antigen, T-Cell; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Calphostin-C stimulates epidermal growth factor receptor phosphorylation and internalization via light-dependent mechanism.
Topics: Alkaloids; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Light; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Naphthalenes; Peptide Mapping; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Proteins; Staurosporine; Trypsin; Tumor Cells, Cultured; Tyrosine | 1994 |
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Glucose; Hippocampus; Homeostasis; Indole Alkaloids; Neurons; Phosphorylation; Phosphotyrosine; Rats; Septum Pellucidum; Staurosporine; Tyrosine | 1994 |
Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal.
Topics: Adenosine Triphosphate; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Catechols; Cell Line; Endocytosis; Genistein; Humans; Isoflavones; Kinetics; Liver Neoplasms; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Transferrin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation.
Topics: Agrin; Alkaloids; Animals; Chick Embryo; Cytoskeleton; Muscles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Nicotinic; Staurosporine; Tyrosine | 1994 |
Okadaic acid, a serine/threonine phosphatase inhibitor, induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in A431 cells.
Topics: Alkaloids; Amino Acid Sequence; Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Kinetics; Molecular Sequence Data; Molecular Weight; Okadaic Acid; Oligopeptides; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinase C; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1994 |
Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation.
Topics: Adenosine Triphosphatases; Alkaloids; Amino Acid Sequence; Amino Acids; Animals; Antigens, CD; Base Sequence; Bile Acids and Salts; Biological Transport; Carrier Proteins; Cell Adhesion Molecules; Cells, Cultured; Consensus Sequence; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Phorbol Esters; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Alkaloids; Amino Acid Sequence; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Molecular Weight; Neutrophils; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Staurosporine; Tyrosine | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Cell spreading in Colo 201 by staurosporin is alpha 3 beta 1 integrin-mediated with tyrosine phosphorylation of Src and tensin.
Topics: Alkaloids; Amino Acid Sequence; Cations, Divalent; Cell Adhesion; Extracellular Matrix; In Vitro Techniques; Integrins; Microfilament Proteins; Molecular Sequence Data; Oligopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptors, Very Late Antigen; Staurosporine; Tensins; Tumor Cells, Cultured; Tyrosine | 1995 |
Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation.
Topics: Alkaloids; Animals; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Tyrosine; Up-Regulation | 1995 |
Transforming growth factor-beta 1 induction of novel extracellular matrix proteins that trigger resistance to tumor necrosis factor cytotoxicity in murine L929 fibroblasts.
Topics: Alkaloids; Animals; Catechols; Cell Survival; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Genistein; Isoflavones; Kinetics; L Cells; Mice; Nitriles; Phenols; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Transforming Growth Factor beta; Tumor Protein, Translationally-Controlled 1; Tyrosine; Tyrphostins | 1995 |
Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor.
Topics: Alkaloids; Blood Platelets; Calcium; Crotalid Venoms; Epoprostenol; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Membrane Glycoproteins; Ristocetin; Staurosporine; Tyrosine; von Willebrand Factor | 1995 |
Bradykinin induces tyrosine phosphorylation of epidermal growth factor-receptor and focal adhesion proteins in human keratinocytes.
Topics: Alkaloids; Bradykinin; Cell Adhesion Molecules; Cell Line; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Immunoblotting; Indoles; Isoflavones; Keratinocytes; Maleimides; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Bradykinin; Staurosporine; Tyrosine | 1995 |
Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells.
Topics: Alkaloids; Animals; Biological Transport; Carbachol; Cell Membrane; Cells, Cultured; Enzyme Activation; Epithelial Cells; Epithelium; ErbB Receptors; Genistein; Isoenzymes; Isoflavones; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Receptor, Insulin; Salivary Glands; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5.
Topics: Alkaloids; Cell Division; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Interleukin-3; Interleukin-5; Kinetics; Leukemia, Erythroblastic, Acute; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; In Vitro Techniques; Interleukin-3; Isoquinolines; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-3; Signal Transduction; Staurosporine; Tyrosine | 1995 |
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1.
Topics: Alkaloids; Animals; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages.
Topics: Acetylcysteine; Alkaloids; Animals; Arginine; Base Sequence; Cell Line; Cell Nucleus; Enzyme Inhibitors; Indomethacin; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Molecular Sequence Data; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Oligonucleotide Probes; omega-N-Methylarginine; Protein Kinase C; Silicon Dioxide; Staurosporine; Tosylphenylalanyl Chloromethyl Ketone; Tyrosine | 1995 |
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor.
Topics: Alkaloids; Amyloid; Carbachol; Cell Line; Genistein; Humans; Isoflavones; Phosphorylation; Prion Proteins; Prions; Protein Kinase Inhibitors; Protein Precursors; Protein Tyrosine Phosphatases; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Shigella flexneri-HeLa cell interactions: a putative role for host cell protein kinases.
Topics: Alkaloids; HeLa Cells; Humans; Phosphorylation; Protein Kinases; Shigella flexneri; Staurosporine; Tyrosine | 1995 |
Staurosporine induces tyrosine phosphorylation of a 145 kDa protein but does not activate gp140trk in PC12 cells.
Topics: Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Mice; Molecular Weight; Neurites; PC12 Cells; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Nerve Growth Factor; Staurosporine; Tyrosine | 1994 |
Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arsenites; Benzophenanthridines; Cell Line; Fibroblasts; Heat-Shock Proteins; Humans; Interleukin-1; Isoquinolines; Phenanthridines; Phosphorylation; Phosphotransferases; Piperazines; Sodium Compounds; Staurosporine; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
Topics: Alkaloids; Amino Acid Sequence; Animals; Caseins; Cells, Cultured; DNA; DNA-Binding Proteins; Genistein; Isoflavones; Janus Kinase 2; Milk Proteins; Models, Molecular; Molecular Sequence Data; Phosphorylation; Prolactin; Protein Binding; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.
Topics: Alkaloids; Base Sequence; Cell Differentiation; Humans; Molecular Sequence Data; Neuroblastoma; Neuropeptide Y; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization.
Topics: Alkaloids; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; Indoles; Inositol Phosphates; Phosphatidic Acids; Phosphorylation; Platelet Aggregation Inhibitors; Precipitin Tests; Serotonin; Signal Transduction; Staurosporine; Type C Phospholipases; Tyrosine | 1994 |
Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Blood Platelets; Egtazic Acid; Humans; Indoles; Inositol Phosphates; Phosphorylation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Staurosporine; Styrenes; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine | 1994 |
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.
Topics: Adenylate Cyclase Toxin; Alkaloids; Animals; Cell Adhesion Molecules; Cells, Cultured; Endothelins; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Kinetics; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Oncogene Protein p21(ras); Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Tyrosine; Virulence Factors, Bordetella | 1994 |
Anti-CD9 monoclonal antibody elicits staurosporine inhibitable phosphatidylinositol 4,5-bisphosphate hydrolysis, phosphatidylinositol 3,4-bisphosphate synthesis, and protein-tyrosine phosphorylation in human platelets.
Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; Blood Platelets; Humans; Membrane Glycoproteins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Protein Kinase C; Staurosporine; Tetraspanin 29; Tyrosine | 1993 |
1,25-dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades.
Topics: Alkaloids; Calcitriol; Cell Differentiation; Enzyme Inhibitors; Genistein; Humans; Indoles; Isoflavones; Leukemia, Promyelocytic, Acute; Maleimides; Monocytes; Phagocytosis; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Protein tyrosine phosphorylation and the regulation of KCl cotransport in trout erythrocytes.
Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Genistein; Isoflavones; Isoproterenol; K Cl- Cotransporters; Marine Toxins; Oncorhynchus mykiss; Oxazoles; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Staurosporine; Symporters; Tyrosine; Vanadates | 1996 |
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.
Topics: Alkaloids; Base Sequence; Calcimycin; Cell Hypoxia; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; I-kappa B Proteins; Ionophores; Isoflavones; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Binding; Protein Kinase C; Protein Tyrosine Phosphatases; src-Family Kinases; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Staurosporine induces neurite outgrowth in neuronal hybrids (PC12EN) lacking NGF receptors.
Topics: Adrenal Medulla; Animals; Biomarkers; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Adhesion Molecules; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibroblast Growth Factors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Hybrid Cells; Karyotyping; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptors, Fibroblast Growth Factor; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine; Tyrosine | 1996 |
Cellular events concurrent with Porphyromonas gingivalis invasion of oral epithelium in vitro.
Topics: Cadaverine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Coated Pits, Cell-Membrane; Colchicine; Cytoskeleton; Endocytosis; Enzyme Inhibitors; Epithelial Cells; Epithelium; Genistein; Humans; Isoflavones; KB Cells; Microtubules; Nasopharynx; Nocodazole; Ouabain; Phosphorylation; Porphyromonas gingivalis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Tyrosine | 1996 |
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carrier Proteins; Cells, Cultured; Cloning, Molecular; DNA-Binding Proteins; Etoposide; Gene Expression Regulation; Liver; Mice; Mutation; Phosphorylation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Staurosporine; Transcription Factors; Transfection; Tyrosine | 1996 |
The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.
Topics: Animals; Biological Transport; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Phosphatase 1; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tyrosine | 1996 |
Tyrosine phosphorylation events during coxsackievirus B3 replication.
Topics: Animals; Benzoquinones; Chlorocebus aethiops; Enterovirus B, Human; Enzyme Inhibitors; HeLa Cells; Humans; Lactams, Macrocyclic; Naphthalenes; Phosphorylation; Precipitin Tests; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Subcellular Fractions; Tyrosine; Vero Cells; Virion; Virus Replication | 1997 |
The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase.
Topics: Benzoquinones; Cell Cycle Proteins; Enzyme Inhibitors; Genistein; Humans; Interferon-alpha; Isoflavones; Lactams, Macrocyclic; Multiple Myeloma; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Quinones; Rifabutin; Staurosporine; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine | 1997 |
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Genistein; Indomethacin; Isoflavones; Male; Naphthalenes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Polyenes; Rabbits; Staurosporine; Type C Phospholipases; Tyrosine | 1997 |
CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells.
Topics: Astrocytoma; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-fos; Staurosporine; Substance P; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1997 |
Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLC gamma 2, independently of integrin alpha IIb beta 3.
Topics: Animals; Crotalid Venoms; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Lectins, C-Type; Phospholipase C gamma; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Solutions; Staurosporine; Type C Phospholipases; Tyrosine | 1998 |
1alpha,25(OH)2-vitamin D3 signaling in chick enterocytes: enhancement of tyrosine phosphorylation and rapid stimulation of mitogen-activated protein (MAP) kinase.
Topics: Animals; Calcitriol; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chickens; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genistein; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Characterization of the hypertonically induced tyrosine phosphorylation of erythrocyte band 3.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Cell Size; Cytosol; Enzyme Inhibitors; Enzyme Precursors; Erythrocytes; Humans; Hypertonic Solutions; Intracellular Signaling Peptides and Proteins; Osmolar Concentration; Phosphoric Monoester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Syk Kinase; Time Factors; Tyrosine | 1998 |
Activation of MAPK homologues by elicitors in tobacco cells.
Topics: Algal Proteins; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fungal Proteins; Glycogen Synthase Kinase 3; Nicotiana; Phosphorylation; Plant Extracts; Plants, Toxic; Reactive Oxygen Species; Staurosporine; Tyrosine | 1998 |
Involvement of protein kinases and phosphatases in tyrosine phosphorylation of PKCdelta in rat parotid acinar cells exposed to secretory stimuli.
Topics: Animals; Carbachol; Carcinogens; Enzyme Inhibitors; Epithelial Cells; Genistein; Isoenzymes; Muscarinic Agonists; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts.
Topics: Amino Acid Sequence; Benzoquinones; Cell Adhesion; Cell Polarity; Cytoplasm; Fibroblasts; Genistein; Lactams, Macrocyclic; Membrane Glycoproteins; Molecular Sequence Data; Phosphorylation; Protein Kinase Inhibitors; Proteoglycans; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Syndecan-2; Syndecan-4; Syndecans; Tyrosine | 1998 |
Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitization of smooth muscle of rabbit mesenteric artery.
Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Carcinogens; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; rho GTP-Binding Proteins; Ribose; Staurosporine; Tyrosine; Tyrphostins; Vasoconstrictor Agents | 1998 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole.
Topics: Alkaloids; Antineoplastic Agents; Carcinoma, Squamous Cell; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell-Free System; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Mitosis; Nocodazole; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1999 |
Interaction of enteropathogenic or enterohemorrhagic Escherichia coli with HeLa cells results in translocation of cortactin to the bacterial adherence site.
Topics: Actins; Bacterial Adhesion; Binding Sites; Cortactin; Cytochalasin D; Enzyme Inhibitors; Escherichia coli; Escherichia coli O157; HeLa Cells; Humans; Microfilament Proteins; Microscopy, Confocal; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Shigella flexneri; Staurosporine; Tyrosine; Virulence | 2000 |
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
Topics: Amino Acid Sequence; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genistein; GTP-Binding Proteins; Indole Alkaloids; Indoles; Lysine; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Receptor, trkB; RNA, Messenger; Staurosporine; Tyrosine; Xenopus | 2000 |
Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arsenicals; Enzyme Inhibitors; Female; Naphthalenes; Phospholipases A; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetramisole; Tyrosine | 2000 |
Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Apoptosis; Catecholamines; Cells, Cultured; Cyclic AMP; Drug Interactions; Epinephrine; Heart Ventricles; Male; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Staurosporine; Tyrosine | 2000 |
Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies.
Topics: Antibodies, Antineutrophil Cytoplasmic; Genistein; Humans; In Vitro Techniques; Kinetics; Mitogen-Activated Protein Kinases; Myeloblastin; Naphthalenes; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Respiratory Burst; Serine Endopeptidases; Signal Transduction; Staurosporine; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Tyrosine kinase-mediated serine phosphorylation of adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Blotting, Western; Catalytic Domain; Cells, Cultured; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Humans; Intracellular Fluid; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoamino Acids; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Rats; Serine; Staurosporine; Tyrosine; Up-Regulation; Vanadates | 2001 |
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta.
Topics: Apoptosis Inducing Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cyclin D1; Enzyme Inhibitors; Flavoproteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hot Temperature; Humans; Lithium; Membrane Proteins; Phosphorylation; Serine; Staurosporine; Tumor Cells, Cultured; Tyrosine | 2001 |
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3.
Topics: Cell Line, Transformed; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Mutation; Organ Specificity; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Tyrosine | 2002 |
Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors.
Topics: Animals; Benzoquinones; Cells, Cultured; Cytoskeletal Proteins; Dystroglycans; Dystrophin-Associated Proteins; Enzyme Inhibitors; Lactams, Macrocyclic; Laminin; Membrane Glycoproteins; Membrane Proteins; Muscle Proteins; Neuromuscular Junction; Neuropeptides; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Rifabutin; Signal Transduction; src-Family Kinases; Staurosporine; Synapses; Tyrosine; Utrophin | 2002 |
Dynamitin controls Beta 2 integrin avidity by modulating cytoskeletal constraint on integrin molecules.
Topics: Animals; Calmodulin-Binding Proteins; CD18 Antigens; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Dynactin Complex; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Ligands; Luminescent Proteins; Membrane Proteins; Mice; Microfilament Proteins; Microscopy, Fluorescence; Microscopy, Video; Microtubule-Associated Proteins; Microtubules; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Recombinant Fusion Proteins; rhoA GTP-Binding Protein; Staurosporine; Time Factors; Transfection; Tyrosine | 2002 |
Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis.
Topics: Animals; Annexin A5; Aorta; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Cycloheximide; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; In Situ Nick-End Labeling; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Staurosporine; Swine; Time Factors; Tyrosine | 2002 |
IgG-mediated signal transduction in canine mastocytoma-derived cells.
Topics: Acridines; Animals; Binding Sites; Calcium; Calcium Signaling; Dogs; Histamine Release; Immunoglobulin E; Immunoglobulin G; Mastocytoma; Neoplasm Proteins; Phosphorylation; Signal Transduction; Staurosporine; Thapsigargin; Tumor Cells, Cultured; Tyrosine | 2002 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event.
Topics: Cell Line; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mutation; Nerve Growth Factor; Phosphorylation; Staurosporine; Tyrosine | 2004 |
mRNA is an endogenous ligand for Toll-like receptor 3.
Topics: Blotting, Northern; Cell Line; Dendritic Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genistein; Humans; Interleukin-1 Receptor-Associated Kinases; Interleukin-8; Ligands; Luciferases; Membrane Glycoproteins; Necrosis; NF-kappa B; Nucleic Acid Conformation; Plasmids; Protein Kinases; Receptors, Cell Surface; RNA; RNA, Double-Stranded; RNA, Messenger; Signal Transduction; Staurosporine; Toll-Like Receptor 3; Toll-Like Receptors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2004 |
A flow cytometric assay for global estimation of tyrosine phosphorylation associated with capacitation of spermatozoa from two marsupial species, the tammar wallaby (Macropus eugenii) and the brushtail possum (Trichosurus vulpecula).
Topics: Animals; Cells, Cultured; Coculture Techniques; Cyclic AMP; Enzyme Inhibitors; Female; Flow Cytometry; Macropodidae; Male; Marsupialia; Opossums; Oviducts; Phosphorylation; Protein Tyrosine Phosphatases; Sheep; Signal Transduction; Sperm Capacitation; Spermatozoa; Staurosporine; Tyrosine; Vanadates | 2004 |
Infection with Campylobacter jejuni induces tyrosine-phosphorylated proteins into INT-407 cells.
Topics: Campylobacter jejuni; Cells, Cultured; Enzyme Inhibitors; Genistein; Humans; Intestines; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Staurosporine; Tyrosine; Tyrphostins | 2004 |
Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells.
Topics: Animals; Arsenicals; Cell Line; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; Genistein; Glycine; Humans; N-Methylaspartate; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor Cross-Talk; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Resorcinols; Staurosporine; Thapsigargin; Transfection; Tyrosine; Vanadates | 2004 |
The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Baculoviridae; Binding Sites; Catalytic Domain; Cloning, Molecular; COS Cells; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorescence Resonance Energy Transfer; Humans; Models, Chemical; Models, Molecular; Molecular Sequence Data; Peptides; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Homology, Amino Acid; src Homology Domains; Staurosporine; Stereoisomerism; Time Factors; Transfection; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2004 |
Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin.
Topics: Adenoviridae; Animals; Animals, Newborn; Apoptosis; Binding Sites; Caspase 3; Caspases; Cell Adhesion; Cell Cycle Proteins; Cells, Cultured; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; DNA; DNA Fragmentation; DNA, Complementary; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Focal Adhesion Kinase 2; Genes, Dominant; Immediate-Early Proteins; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Microscopy, Fluorescence; Models, Biological; Mutation; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Paxillin; Phenotype; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Staurosporine; Time Factors; Tyrosine; Vinculin | 2004 |
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Topics: Animals; Anticarcinogenic Agents; Antigens; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Glutathione; Humans; Isothiocyanates; Male; Membrane Potentials; Mice; Mice, SCID; Microscopy, Fluorescence; Mitochondria; Mitosis; Neoplasm Transplantation; Neoplasms; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Staurosporine; Sulfoxides; Thiocyanates; Time Factors; Tyrosine | 2004 |
Regulatory and necrotic volume increase in boar spermatozoa.
Topics: Animals; Annexin A5; Cell Size; Chloride Channels; Enzyme Inhibitors; Hypertonic Solutions; Male; Necrosis; Phenols; Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Quinidine; Semen Preservation; Spermatozoa; Staining and Labeling; Staurosporine; Swine; Tamoxifen; Tyrosine; Vanadates | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
Topics: Active Transport, Cell Nucleus; Animals; Anisomycin; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Etoposide; Fibroblasts; Genes, Dominant; Humans; Hypoxia; Imidazoles; Immunoprecipitation; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Oxidoreductases; Phosphorylation; Piperazines; Proteasome Endopeptidase Complex; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; U937 Cells; Ultraviolet Rays; WW Domain-Containing Oxidoreductase | 2005 |
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.
Topics: Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Cell Line; DNA, Neoplasm; Enzyme Activation; fms-Like Tyrosine Kinase 3; Humans; In Vitro Techniques; Interleukin-3; Leukemia, Myeloid, Acute; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Structure, Tertiary; Recombinant Proteins; STAT5 Transcription Factor; Staurosporine; Tyrosine | 2006 |
Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance.
Topics: Apoptosis; Caspase 3; Cell Cycle; Cells, Cultured; Cellular Senescence; Collagen Type XI; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydrogen Peroxide; Oxidants; Phosphorylation; RNA, Small Interfering; src-Family Kinases; Staurosporine; Tyrosine | 2006 |
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Imatinib Mesylate; Male; Mice; Mice, Nude; Phosphorylation; Piperazines; Point Mutation; Protein Kinase Inhibitors; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; Staurosporine; Tyrosine; Xenograft Model Antitumor Assays | 2006 |
Activation mechanism and steady state kinetics of Bruton's tyrosine kinase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Agammaglobulinaemia Tyrosine Kinase; Binding Sites; Binding, Competitive; Enzyme Activation; Humans; Kinetics; Models, Chemical; Mutation; Peptides; Protein Binding; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 2007 |
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Stability; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Thiazoles; Tyrosine; Up-Regulation | 2011 |
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
Topics: Amino Acid Motifs; Catalysis; Crystallography, X-Ray; Cysteine; Disulfides; Dyrk Kinases; Humans; Models, Molecular; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 2015 |
Population-based metagenomics analysis reveals altered gut microbiome in sarcopenia: data from the Xiangya Sarcopenia Study.
Topics: alpha-Linolenic Acid; Bacteroides; Clostridiaceae; Clostridiales; Desulfovibrio; Female; Furaldehyde; Gastrointestinal Microbiome; Humans; Middle Aged; Phenylalanine; RNA, Ribosomal, 16S; Sarcopenia; Staurosporine; Tryptophan; Tyrosine | 2022 |