staurosporine has been researched along with tretinoin in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.79) | 18.7374 |
| 1990's | 24 (42.86) | 18.2507 |
| 2000's | 16 (28.57) | 29.6817 |
| 2010's | 12 (21.43) | 24.3611 |
| 2020's | 3 (5.36) | 2.80 |
| Authors | Studies |
|---|---|
| Athanassopoulos, CM; Bariamis, SE; Dedes, PG; Haskopoulos, A; Karamanos, NK; Kletsas, D; Krokidis, MG; Magoulas, GE; Maroulis, G; Papaioannou, D | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Afratis, K; Gavras, H; Karamanos, NK; Koutsakis, C; Leonardi, S; Papaioannou, D; Piperigkou, Z; Rassias, G; Rigopoulou, D; Vachlioti, E | 1 |
| Holmes, R; Kelly, E; Perez, HD | 1 |
| al-Mazidi, H; Gregor, A; Lach, B; Proulx, P; Slack, R | 1 |
| Ishihara, H; Shikita, M; Takeuchi, K; Tsuneoka, K | 1 |
| Proulx, P; Slack, RS | 1 |
| Kato, Y; Mochizuki, T; Okazaki, T; Sawada, H; Tashima, M; Uchino, H | 1 |
| Sauro, MD; Zorn, NE | 1 |
| Arai, T; Irino, S; Kawanishi, K; Kiuchi, H; Takahara, J; Tanaka, T; Taoka, T; Yamaoka, G | 1 |
| Belayew, A; Bulens, F; Collen, D; De Vriese, A; Ibañez-Tallon, I; Nelles, L; Van Acker, P | 1 |
| Chiu, R; Evans, RM; Gachelin, G; Kitabayashi, I; Umesono, K; Yokoyama, K | 1 |
| Audette, M; Bouillon, M | 1 |
| Gañan, Y; Hurlé, JM; Macias, D | 1 |
| Houde, M; Mandeville, R; Masure, S; Opdenakker, G; Oth, D; Tremblay, P | 1 |
| Adolphe, M; Borge, L; Demignot, S | 1 |
| Anzano, M; Byers, S; Crockett, C; Lechleider, R; Peer, C; Pishvaian, M; Sporn, M; Tozeren, A | 1 |
| Byers, DM; Cook, HW; Mandla, SG; Ridgway, ND | 1 |
| Fujita, I; Koga, H; Miyazaki, S | 1 |
| Atkins, KB; Simpson, RU; Somerman, MJ | 1 |
| Oreland, L; Prince, JA | 1 |
| Barsig, J; Nüsing, RM | 1 |
| Ahlemeyer, B; Krieglstein, J | 2 |
| Hagino, T; Kobayashi, D; Niitsu, Y; Okamoto, T; Sasaki, H; Sato, T; Tsuji, N; Watanabe, N; Yamauchi, N | 1 |
| Carter, CA; Chambers, T; Parham, GP | 1 |
| Bigas, A; Chernukhin, IV; Delgado, MD; Klenova, EM; León, J | 1 |
| Tieu, K; Yu, PH; Zuo, DM | 1 |
| Amendola, A; Oliverio, S; Piacentini, M; Rodolfo, C; Spinedi, A | 1 |
| Ahlemeyer, B; Hühne, R; Krieglstein, J | 1 |
| Billardon, C; Carvajal-Gonzalez, S; Gompel, A; Kandouz, M; Lombet, A; Rostène, W; Zujovic, V | 1 |
| Ahlemeyer, B; Bauerbach, E; Heers, C; Krieglstein, J; Plath, M; Steuber, M; Tegtmeier, F | 1 |
| Carter, CA | 1 |
| Hong, HY; Varvayanis, S; Yen, A | 1 |
| Costa, S; Fages, C; Monville, C; Paillaud, E; Plassat, JL; Rochette-Egly, C; Tardy, M | 1 |
| Addicks, K; Arnhold, S; Doerfler, W; Schumacher, A | 1 |
| Kirsch, T; Pfander, D; Wang, W | 1 |
| Beck, J; Chen, J; Chernenko, G; Liu, H; Pater, A; Tang, SC; Xiong, J | 1 |
| Alonso, M; Cortes-Canteli, M; Luna-Medina, R; Martínez, A; Perez-Castillo, A; Santos, A | 1 |
| Castro-Muñozledo, F; Diaz-Velasquez, CE; Kuri-Harcuch, W | 1 |
| Ahokas, K; Elomaa, O; Forsberg, S; Jeskanen, L; Lohi, J; Pärssinen, J; Pasonen-Seppänen, SM; Rollman, O; Saarialho-Kere, U; Skoog, T; Tiala, I | 1 |
| Tallman, M | 1 |
| Karp, J | 1 |
| Emmanouilidou, E; Stefanis, L; Vekrellis, K; Xilouri, M | 1 |
| Basta-Kaim, A; Budziszewska, B; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Lipkowski, AW | 1 |
| Abboud, CN; Cashen, A; Dipersio, JF; Fiala, M; McBride, A; Ramsingh, G; Stockerl-Goldstein, K; Uy, G; Vij, R; Westervelt, P | 1 |
| Chen, X; Fan, Y; Guo, N; Han, J; Yang, B; Zhang, L | 1 |
| Cai, X; Ge, DZ; Sheng, Y | 1 |
| Chi, HT; Dung, PC; Ly, BT; Sato, Y; Vu, HA; Xinh, PT | 1 |
| Beltramini, M; Bisaglia, M; Bubacco, L; Civiero, L; Codolo, G; Ferrari, V; Filograna, R; Greggio, E | 1 |
| Cai, X; Ding, M; Sheng, Y; Shi, L; Weng, XQ; Wu, J | 1 |
| Cai, X; Ding, M; Liang, C; Sheng, Y; Weng, XQ; Wu, J | 1 |
| Ducray, AD; Frenz, M; Mevissen, M; Stoffel, MH; Widmer, HR; Wiedmer, L | 1 |
| Ducray, A; Mevissen, M; Murbach, M; von Niederhäusern, N; Zielinski, J | 1 |
| Naoe, T | 1 |
| Cai, X; Lu, H; Sheng, Y; Weng, XQ; Wu, J; Xi, HM | 1 |
2 review(s) available for staurosporine and tretinoin
| Article | Year |
|---|---|
Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Delivery Systems; Enzyme Inhibitors; Gastrointestinal Neoplasms; Humans; Isoenzymes; Lung Neoplasms; Neoplasm Proteins; Neoplasms; Oligonucleotides, Antisense; Protein Kinase C; Retinoids; Staurosporine; Tretinoin | 2000 |
＜Editors' Choice＞ How to improve outcomes of elderly patients with acute myeloid leukemia: era of excitement.
Topics: Aged; Aged, 80 and over; Aminopyridines; Aniline Compounds; Antineoplastic Agents; Arsenic Trioxide; Azacitidine; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Decitabine; fms-Like Tyrosine Kinase 3; Humans; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Phenylurea Compounds; Precision Medicine; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Smoothened Receptor; Staurosporine; Sulfonamides; Survival Rate; Tretinoin; Triazines | 2020 |
1 trial(s) available for staurosporine and tretinoin
| Article | Year |
|---|---|
Phase I study of cladribine, cytarabine, granulocyte colony stimulating factor (CLAG regimen) and midostaurin and all-trans retinoic acid in relapsed/refractory AML.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cytarabine; Female; fms-Like Tyrosine Kinase 3; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Nuclear Proteins; Nucleophosmin; Recurrence; Remission Induction; Staurosporine; Treatment Outcome; Tretinoin | 2014 |
53 other study(ies) available for staurosporine and tretinoin
| Article | Year |
|---|---|
Syntheses, antiproliferative activity and theoretical characterization of acitretin-type retinoids with changes in the lipophilic part.
Topics: Acitretin; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Quantum Theory; Retinoids; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Topics: Anti-Bacterial Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Quinolines; Receptor, Bradykinin B2 | 2021 |
Regulation of formyl peptide receptor expression and its mRNA levels during differentiation of HL-60 cells.
Topics: Alkaloids; Binding Sites; Bucladesine; Cell Differentiation; Chromatography, Liquid; Colforsin; Dexamethasone; Drug Antagonism; Gene Expression Regulation; Humans; Protein Kinase C; Protein Kinases; Receptors, Formyl Peptide; Receptors, Immunologic; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1992 |
Retinoic acid- and staurosporine-induced bidirectional differentiation of human neuroblastoma cell lines.
Topics: Alkaloids; Cell Differentiation; Cell Line; Humans; Melanocytes; Microscopy, Electron; Monophenol Monooxygenase; Neurites; Neuroblastoma; Neurons; Protein Kinase C; Staurosporine; Tretinoin | 1992 |
Barbiturates enhance retinoic acid or 1,25-dihydroxyvitamin D3-induced differentiation of leukemia HL-60 cells.
Topics: Alkaloids; Barbiturates; Bucladesine; Calcitriol; Cell Differentiation; Cell Line; Dactinomycin; Dimethyl Sulfoxide; Granulocytes; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Macrophages; Monocytes; Pentobarbital; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1991 |
Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines.
Topics: Alkaloids; Cell Differentiation; Cytosol; Edetic Acid; Fibroblasts; Humans; Neuroblastoma; Neurons; Protein Kinase C; Staurosporine; Tretinoin; Tumor Cells, Cultured | 1990 |
Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Calcitriol; Cell Differentiation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1988 |
Retinoic acid induces translocation of protein kinase C (PKC) and activation of nuclear PKC (nPKC) in rat splenocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Biological Transport; Cell Nucleus; Cytosol; Enzyme Activation; Isoquinolines; Lymphocytes; Male; Nuclear Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Sphingosine; Spleen; Staurosporine; Tretinoin | 1995 |
Alkaline phosphatase activity in the human promyelocytic leukemia cell line, HL-60, induced by retinoic acid and recombinant human granulocyte colony-stimulating factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Calcitriol; Cell Line; Enzyme Induction; Granulocyte Colony-Stimulating Factor; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Recombinant Proteins; Staurosporine; Tretinoin; Tumor Cells, Cultured | 1993 |
Retinoic acid induction of human tissue-type plasminogen activator gene expression via a direct repeat element (DR5) located at -7 kilobases.
Topics: Alkaloids; Animals; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; DNA; Dose-Response Relationship, Drug; Endothelium; Enzyme Induction; Fibrosarcoma; Gene Expression; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Mutagenesis; Neuroblastoma; Oligodeoxyribonucleotides; Protein Kinase C; Protein Multimerization; Rats; Receptors, Retinoic Acid; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Sequence Deletion; Staurosporine; Tissue Plasminogen Activator; Transcription Factors; Transfection; Tretinoin; Tumor Cells, Cultured | 1995 |
A novel pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptor-mediated trans-activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Differentiation; Genes, jun; Isoquinolines; Mice; Phosphoproteins; Piperazines; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Staurosporine; Teratocarcinoma; Time Factors; Transcriptional Activation; Tretinoin; Tumor Cells, Cultured | 1994 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation; Glioma; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Modification of the phalangeal pattern of the digits in the chick embryo leg bud by local microinjection of RA, staurosporin and TGF beta's.
Topics: Alkaloids; Animals; Chick Embryo; Hindlimb; Microscopy, Electron, Scanning; Staurosporine; Toes; Transforming Growth Factor beta; Tretinoin | 1993 |
Synergistic and selective stimulation of gelatinase B production in macrophages by lipopolysaccharide, trans-retinoic acid and CGP 41251, a protein kinase C regulator.
Topics: Alkaloids; Animals; Base Sequence; Cells, Cultured; Collagenases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; In Vitro Techniques; Lipopolysaccharides; Macrophages; Matrix Metalloproteinase 9; Molecular Sequence Data; Protein Kinase C; Rats; Rats, Inbred F344; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Tretinoin; Up-Regulation | 1996 |
Type II transglutaminase expression in rabbit articular chondrocytes in culture: relation with cell differentiation, cell growth, cell adhesion and cell apoptosis.
Topics: Alkaloids; Animals; Apoptosis; Blotting, Western; Cartilage, Articular; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Collagen; Cytochalasin B; DNA; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Microscopy, Phase-Contrast; Rabbits; Staurosporine; Transglutaminases; Tretinoin | 1996 |
Retinoids increase cell-cell adhesion strength, beta-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: a role for serine kinase activity.
Topics: beta Catenin; Breast Neoplasms; Cadherins; Calcium; Cell Adhesion; Cell Differentiation; Cell Membrane; Culture Media; Cytoskeletal Proteins; Drug Stability; Epithelium; Female; Humans; Indoles; Maleimides; Protein Serine-Threonine Kinases; RNA, Messenger; Staurosporine; Tissue Distribution; Trans-Activators; Tretinoin; Tumor Cells, Cultured | 1996 |
Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Clofibrate; Enzyme Inhibitors; Ethanolamine; Ethanolamines; Fibroblasts; Humans; Hypolipidemic Agents; Isoquinolines; Phosphatidylcholines; Phospholipids; Protein Kinase C; Skin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1996 |
Effects of all-trans-retinoic acid on superoxide generation in intact neutrophils and a cell-free system.
Topics: Androstadienes; Calcium; Cell Communication; Cell-Free System; Dose-Response Relationship, Drug; Humans; Neutrophils; Staurosporine; Superoxides; Tretinoin; Wortmannin | 1997 |
Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation.
Topics: Alkaloids; Benzophenanthridines; Butyrates; Butyric Acid; Calcitriol; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Osteopontin; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tretinoin | 1997 |
Staurosporine differentiated human SH-SY5Y neuroblastoma cultures exhibit transient apoptosis and trophic factor independence.
Topics: Apoptosis; Aurintricarboxylic Acid; Calcium Channels; Cell Differentiation; Cell Survival; Electrophysiology; Enzyme Inhibitors; Humans; Ion Channel Gating; Nerve Growth Factors; Neuroblastoma; Neurons; Norepinephrine; Phenotype; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1997 |
Inflammatory potency of activin A. Effect on prostanoid and nitric oxide formation.
Topics: Activins; Animals; Bone Marrow Cells; Cell Differentiation; Cinnamates; Cyclooxygenase 2; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Genistein; Inflammation; Inhibins; Interleukin-2; Isoenzymes; Lipopolysaccharides; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Necrosis Factor-alpha; Tyrphostins | 1997 |
Retinoic acid reduces staurosporine-induced apoptotic damage in chick embryonic neurons by suppressing reactive oxygen species production.
Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Survival; Cells, Cultured; Chick Embryo; Chromatin; Dose-Response Relationship, Drug; Mitochondria; Neurons; Reactive Oxygen Species; Staurosporine; Tretinoin | 1998 |
Differentiation induction by a tumor-necrosis-factor mutant 471 in human myelogenous leukemic cells via tumor-necrosis-factor receptor-p55.
Topics: Antigens, CD; Antineoplastic Agents; Cell Differentiation; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Mutation; Protein Kinase C; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Staurosporine; Transduction, Genetic; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-alpha.
Topics: Adenocarcinoma; Antineoplastic Agents; Carbazoles; Cell Differentiation; Cytoskeleton; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Indoles; Isoenzymes; Maleimides; Phenotype; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tretinoin; Tumor Cells, Cultured; Uterine Neoplasms | 1998 |
Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells.
Topics: Blotting, Northern; Blotting, Western; Burkitt Lymphoma; CCCTC-Binding Factor; Cell Differentiation; Cytarabine; Dimethyl Sulfoxide; DNA-Binding Proteins; Down-Regulation; Erythrocytes; Gene Expression Regulation; Humans; Isoelectric Focusing; Leukemia, Myeloid; Leukocytes; Megakaryocytes; Phosphorylation; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA Processing, Post-Transcriptional; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1999 |
Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins.
Topics: Benzylamines; Cell Differentiation; Cell Survival; Fluorouracil; Gamma Rays; Humans; Neuroblastoma; Neurotoxins; Oxidopamine; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Chick Embryo; Culture Media, Serum-Free; Glutathione; Neurons; Oxidation-Reduction; Oxidative Stress; Staurosporine; Telencephalon; Tretinoin; Vitamin E | 2000 |
Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis.
Topics: Apoptosis; Calcimycin; Cell Death; Cell Survival; Cycloheximide; Dactinomycin; DNA, Antisense; Gene Expression Regulation, Enzymologic; Humans; Naphthalenes; RNA, Antisense; Staurosporine; Transcription, Genetic; Transfection; Transglutaminases; Tretinoin; Tumor Cells, Cultured | 1999 |
Retinoic acid potentiated the protective effect of NGF against staurosporine-induced apoptosis in cultured chick neurons by increasing the trkA protein expression.
Topics: Animals; Apoptosis; Carrier Proteins; Cells, Cultured; Chick Embryo; Drug Synergism; Membrane Proteins; Nerve Growth Factor; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Receptor, trkA; Signal Transduction; Staurosporine; Tretinoin | 2000 |
Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.
Topics: Androstadienes; Apoptosis; Bacterial Proteins; Bacterial Toxins; bcl-X Protein; Biomarkers; Cell Differentiation; Cell Size; DNA Fragmentation; Gene Expression Regulation; Humans; Microtubule-Associated Proteins; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphopyruvate Hydratase; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; rhoA GTP-Binding Protein; Signal Transduction; Staurosporine; Synaptophysin; Tetradecanoylphorbol Acetate; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Wortmannin | 2001 |
Retinoic acid reduces apoptosis and oxidative stress by preservation of SOD protein level.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cells, Cultured; Hippocampus; Microscopy, Fluorescence; Neurons; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; RNA, Messenger; Staurosporine; Superoxide Dismutase; Superoxide Dismutase-1; Tretinoin | 2001 |
Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells.
Topics: Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Inhibitory Concentration 50; Interphase; Maleimides; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Naphthalenes; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Staurosporine; Transcription Factors; Tretinoin | 2001 |
Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Carcinogens; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Protein Transport; Receptors, Retinoic Acid; RNA, Messenger; STAT3 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Tretinoin; Tumor Cells, Cultured | 2002 |
Staurosporine is a potent activator of neuronal, glial, and "CNS stem cell-like" neurosphere differentiation in murine embryonic stem cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Mice; Multipotent Stem Cells; Nerve Growth Factor; Neurites; Neuroglia; Neurons; Protein Kinase C; Spheroids, Cellular; Staurosporine; Tretinoin | 2003 |
Functional differences between growth plate apoptotic bodies and matrix vesicles.
Topics: Alkaline Phosphatase; Animals; Annexins; Anthraquinones; Apoptosis; Calcium; Caspase 3; Caspases; Cell Division; Chick Embryo; Chondrocytes; Coloring Agents; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Extracellular Matrix; fas Receptor; Immunoblotting; In Situ Nick-End Labeling; Microscopy, Electron; Staurosporine; Tibia; Tretinoin | 2003 |
Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways.
Topics: Antineoplastic Agents; Antisense Elements (Genetics); Apoptosis; Carrier Proteins; Cell Survival; Cytochromes c; DNA-Binding Proteins; Down-Regulation; Drug Resistance; Fenretinide; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Paclitaxel; Signal Transduction; Staurosporine; Transcription Factors; Transfection; Tretinoin | 2003 |
Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.
Topics: Alitretinoin; Anilides; Animals; Anti-Inflammatory Agents; Apoptosis; Astrocytes; Brain; Cell Death; Cell Line; Cell-Free System; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; In Vitro Techniques; Inflammation; Interleukin-6; Lipopolysaccharides; Lithium Chloride; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Models, Chemical; Neurodegenerative Diseases; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; PPAR gamma; Prostaglandin-Endoperoxide Synthases; Rats; Staurosporine; Thiazolidinediones; Time Factors; Transfection; Tretinoin; Tumor Necrosis Factor-alpha | 2005 |
Staurosporine rapidly commits 3T3-F442A cells to the formation of adipocytes by activation of GSK-3beta and mobilization of calcium.
Topics: Adipocytes; Adipogenesis; Animals; Calcium; Cell Line; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lithium Chloride; Mice; Staurosporine; Time Factors; Tretinoin | 2008 |
Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Collagen; Dexamethasone; Filaggrin Proteins; Gene Expression Regulation, Enzymologic; Humans; Keratinocytes; Matrix Metalloproteinases, Secreted; Rats; Staurosporine; Tretinoin | 2009 |
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin | 2008 |
Future research directions for the treatment of AML.
Topics: Antineoplastic Agents; Azacitidine; Biomedical Research; Carbazoles; Carboplatin; Cytarabine; Daunorubicin; Decitabine; Enzyme Inhibitors; Etoposide; Flavonoids; Furans; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Piperidines; Quinolones; Staurosporine; Topotecan; Tretinoin | 2008 |
Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.
Topics: alpha-Synuclein; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspases; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Inositol; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Staurosporine; Time Factors; Transfection; Tretinoin | 2009 |
Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Differentiation; Cell Line, Tumor; Convulsants; Cytotoxins; Homocysteine; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Neuroblastoma; Neuroprotective Agents; Nitro Compounds; Oxidants; Phosphatidylinositol 3-Kinases; Propionates; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Thyrotropin-Releasing Hormone; Tretinoin | 2010 |
Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cells.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fibrosis; Glomerular Mesangium; Mesangial Cells; Nitrobenzenes; Protein Transport; Rats; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad7 Protein; Staurosporine; Sulfonamides; Thromboxane A2; Transforming Growth Factor beta; Tretinoin | 2014 |
Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines.
Topics: CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Granulocytes; Humans; Leukemia, Promyelocytic, Acute; Mitogen-Activated Protein Kinases; Oncogene Proteins, Fusion; Phosphorylation; Staurosporine; Tretinoin | 2014 |
Synergistic effect of all‑trans retinoic acid in combination with protein kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mutation; Protein Kinase Inhibitors; Staurosporine; Tretinoin | 2015 |
Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation.
Topics: Catecholamines; Cell Differentiation; Cell Line, Tumor; Humans; Neuroblastoma; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin | 2015 |
Staurosporine enhances ATRA-induced granulocytic differentiation in human leukemia U937 cells via the MEK/ERK signaling pathway.
Topics: CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Staurosporine; Tretinoin; U937 Cells | 2016 |
The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Leukemia, Promyelocytic, Acute; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-raf; Staurosporine; Tretinoin | 2019 |
Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Survival; Cholinergic Neurons; Dopaminergic Neurons; Humans; Nanoparticles; Phenotype; Polyesters; Signal Transduction; Silicon Dioxide; Staurosporine; Tretinoin | 2019 |
Effects of radiofrequency electromagnetic field exposure on neuronal differentiation and mitochondrial function in SH-SY5Y cells.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Phone; Electromagnetic Fields; Humans; Mitochondria; Neurons; Radio Waves; Staurosporine; Tretinoin | 2019 |
Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3.
Topics: Animals; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Staurosporine; Tretinoin | 2022 |