staurosporine has been researched along with thiazoles in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (23.08) | 18.2507 |
| 2000's | 30 (46.15) | 29.6817 |
| 2010's | 19 (29.23) | 24.3611 |
| 2020's | 1 (1.54) | 2.80 |
| Authors | Studies |
|---|---|
| Pek, SB; Thomas, TP | 1 |
| de Médicis, R; Gilbert, C; Grimard, M; Lussier, A; Naccache, PH; Poubelle, PE; Roberge, CJ | 1 |
| Hiura, M; Ishibashi, S; Ohtsuka, T; Okamura, N; Yoshida, K | 1 |
| Goodrum, DD; Sachs, G; Wheeler, LA | 1 |
| Gavioli, R; Lanza, F; Moretti, S; Reali, E; Spisani, S; Traniello, S | 1 |
| Inagami, T; Inui, H; Kitami, Y; Kondo, T; Konishi, F | 1 |
| Livne, AA; Packham, MA; Rand, ML; Ruben, DH | 1 |
| Cherington, V; Corbley, MJ; Lydon, NB; Roberts, TM; Traxler, PM | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Brown, ER; Dempsey, BK; Lew, DB; Malik, KU; Wright, HM | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Fahrig, T; Struppeck, H; Suchanek, B | 1 |
| Battaglia, A; Canonico, PL; Carfagna, N; Pamparana, F; Post, C; Sortino, MA | 1 |
| Kolega, J; Kumar, S | 1 |
| Kim, JY; Lee, SH; Moon, CH; Woo, HG | 1 |
| Ahlemeyer, B; Beier, H; Krieglstein, J; Schaper, C; Semkova, I | 1 |
| Kong, JY; Rabkin, SW | 1 |
| Knaggs, AR | 1 |
| Burns, AR; Henson, JH; Kolnik, SE; McPartland, KJ; Nazarian, R; Schulberg, KL; Trabosh, VA | 1 |
| Chernyak, BV; Pletjushkina, OY; Popova, EN; Shchepina, LA | 1 |
| Eckert, A; Haass, C; Leutz, S; Marques, CA; Müller, WE; Steiner, B | 1 |
| Alves da Costa, C; Ancolio, K; Checler, F; Mattson, MP | 1 |
| Neher, E; Sakaba, T | 1 |
| Gupta, A; Hoffman, RM; Miki, K; Moossa, AR; Tomita, K; Tsuchiya, H; Tsujimoto, Y; Xu, M; Yamamoto, N | 1 |
| Cao, C; Cho, KW; Han, JH; Kim, SH; Kim, SZ | 1 |
| Almeida, S; Gil, J; Oliveira, CR; Rego, AC | 1 |
| Deveraux, QL; Engels, IH; Wagner, KW | 1 |
| Akaike, A; Hashino, A; Kaneko, S; Katsuki, H; Kume, T; Osakada, F | 1 |
| Hallmann, A; Kamiński, M; Karbowski, M; Kedzior, J; Knap, D; Kurono, C; Majczak, A; Masaoka, M; Niemczyk, E; Soji, T; Wakabayashi, T | 1 |
| Blagden, S; de Bono, J | 1 |
| Charras, GT; Horton, MA; Mahadevan, L; Mitchison, TJ; Yarrow, JC | 1 |
| Armstrong, SA; Beverloo, HB; de Lorenzo, P; den Boer, ML; Horstmann, M; Nollau, P; Pieters, R; Sallan, SE; Schneider, P; Stam, RW; Valsecchi, MG; van der Voort, E | 1 |
| Aguirre, N; Ceña, V; Fernandez-Gomez, FJ; Galindo, MF; Gomez-Lazaro, M; González-García, C; Jordán, J | 1 |
| Ankarcrona, M; Cedazo-Minguez, A; Hansson, CA; Laudon, H; Popescu, BO; Popescu, LM; Winblad, B | 1 |
| Charlot, JF; Mougin, C; Nicolier, M; Prétet, JL | 1 |
| von Mehren, M | 1 |
| Chander, R; Deorukhkar, AA; Pandey, R; Sainis, KB | 1 |
| Aichberger, KJ; Baumgartner, C; Fabbro, D; Gleixner, KV; Gruze, A; Lee, FY; Manley, PW; Mayerhofer, M; Pickl, WF; Samorapoompichit, P; Sillaber, C; Sonneck, K; Valent, P | 1 |
| Bui, B; Italiano, A | 1 |
| Clement, M; Dix, C; Einsele, H; Fenton-May, A; Gostick, E; Greiner, E; Price, DA; Seggewiss, R; Sewell, AK; Weichsel, R; Wooldridge, L; Zezula, J | 1 |
| Baczynska, D; Brézillon, S; Malicka-Blaszkiewicz, M; Maquart, FX; Nowak, D; Popow, A; Radwanska, A; Wegrowski, Y | 1 |
| Contestabile, A; Eleuteri, S; Polazzi, E | 1 |
| Tallman, M | 1 |
| Auger, R; Daniel, H; Delarasse, C; Galante, M; Gonnord, P; Kanellopoulos, JM; Motta, I | 1 |
| Baumgartner, C; Gleixner, KV; Gruze, A; Hadzijusufovic, E; Peter, B; Pickl, WF; Rebuzzi, L; Thaiwong, T; Valent, P; Willmann, M; Yuzbasiyan-Gurkan, V | 1 |
| Ashman, LK; Griffith, R; Mashkani, B | 1 |
| Gleixner, KV; Hadzijusufovic, E; Mirkina, I; Peter, B; Pickl, WF; Schuch, K; Thaiwong, T; Valent, P; Willmann, M; Yuzbasiyan-Gurkan, V | 1 |
| Pardanani, A | 1 |
| Akin, C; DeRemer, DL; Ustun, C | 1 |
| Andrich, K; Dalhoff, C; Dreger, M; Fischer, JJ; Glinski, M; Graebner, OY; Koester, H; Kroll, F; Michaelis, S; Schrey, AK; Sefkow, M | 1 |
| Bennett, KL; Cerny-Reiterer, S; Gleixner, KV; Gotlib, J; Hadzijusufovic, E; Hörmann, G; Horny, HP; Mayerhofer, M; Meyer, RA; Mitterbauer-Hohendanner, G; Pickl, WF; Reiter, A; Rix, U; Superti-Furga, G; Valent, P | 1 |
| Cho, SH; Hwang, SY; Lee, BH; Lee, EK; Song, YJ | 1 |
| Akita, K; Fujii, I; Gouda, M; Ishihama, Y; Kirii, Y; Kitagawa, D; Narumi, Y; Sugiyama, N; Yokota, K | 1 |
| Adamia, S; Barrett, R; Daley, JF; Fox, E; Frank, D; Griffin, JD; Nelson, E; Ray, A; Sattler, M; Weisberg, E; Zhang, C | 1 |
| Jessen, B; Lee, DU | 1 |
| Fox, TE; Gowda, R; Hengst, J; Madhunapantula, SV; Robertson, GP; Yun, JK | 1 |
| Bronson, R; Christie, AL; Daley, JF; Galinsky, I; Gray, N; Griffin, JD; Hur, W; Kung, AL; Liu, Q; Mitsiades, C; Nelson, E; Sanda, T; Sattler, M; Smith, R; Stone, R; Weisberg, E; Zhao, Z | 1 |
| Fu, P; Gu, K; Liu, P; Qi, X; Wang, Y; Zhang, D; Zhu, W; Zhuang, Y | 1 |
| Baptista, MS; Martins, WK; Severino, D; Souza, C; Stolf, BS | 1 |
| Lancet, JE | 1 |
| Barra, FF; Costa, FF; de Melo Campos, P; Duarte, AS; Lorand-Metze, I; Machado-Neto, JA; Olalla Saad, ST; Rogers, HJ; Scopim-Ribeiro, R; Tabarroki, A; Tiu, RV; Traina, F; Vassalo, J; Visconte, V | 1 |
| Bauer, K; Cerny-Reiterer, S; Hadzijusufovic, E; Hoermann, G; Pirker, A; Reifinger, M; Valent, P; Willmann, M | 1 |
| Almasry, M; Faggio, C; Jemaà, M; Lang, F; Mischitelli, M | 1 |
| Backman, JT; Filppula, AM; Mustonen, TM | 1 |
| Hu, L; Li, Y; Ruan, C; Wang, Q; Wang, S; Ye, M; Zhang, X | 1 |
6 review(s) available for staurosporine and thiazoles
| Article | Year |
|---|---|
The biosynthesis of shikimate metabolites.
Topics: 3-Deoxy-7-Phosphoheptulonate Synthase; 3-Phosphoshikimate 1-Carboxyvinyltransferase; Alkyl and Aryl Transferases; Animals; Anthranilate Synthase; Bacteria; Betalains; Catalysis; Chorismate Mutase; Coumarins; Flavonoids; Hydro-Lyases; Indoleacetic Acids; Indoles; Intramolecular Transferases; Lignans; Molecular Structure; Penicillium; Phenylalanine; Phenylpropionates; Phosphorus-Oxygen Lyases; Prephenate Dehydratase; Prephenate Dehydrogenase; Pristinamycin; Pyrrolnitrin; Quaternary Ammonium Compounds; Quinones; Shikimic Acid; Staurosporine; Tannins; Thiazoles; Thyroxine; Tryptophan; Tyrosine; Ubiquinone | 2001 |
Drugging cell cycle kinases in cancer therapy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles | 2005 |
Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Bevacizumab; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Everolimus; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Niacinamide; Oligonucleotides; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sirolimus; Staurosporine; Sunitinib; Thiazoles | 2006 |
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles | 2008 |
Tyrosine kinase inhibitors in the treatment of systemic mastocytosis.
Topics: Animals; Benzamides; Dasatinib; Humans; Imatinib Mesylate; Mastocytosis, Systemic; Mutation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Thiazoles | 2011 |
New agents: great expectations not realized.
Topics: Aminoglycosides; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Benzothiazoles; Cytosine; Gemtuzumab; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Naphthyridines; Phenylurea Compounds; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Remission Induction; Staurosporine; Survival Analysis; Thiazoles; Treatment Failure; Vorinostat | 2013 |
59 other study(ies) available for staurosporine and thiazoles
| Article | Year |
|---|---|
Diacylglycerol inhibits potassium-induced calcium influx and insulin release by a protein kinase-C-independent mechanism in HIT T-15 islet cells.
Topics: Alkaloids; Calcium; Calcium Channel Blockers; Cell Line; Diglycerides; Drug Synergism; Insulin; Islets of Langerhans; Potassium; Potassium Chloride; Protein Kinase C; Pyrimidinones; Staurosporine; Thiazoles | 1992 |
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Topics: Alkaloids; Calcium; Calcium Pyrophosphate; Carbazoles; Cholera Toxin; Colchicine; Crystallization; Cytochalasin B; Cytoplasm; Diacylglycerol Kinase; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indole Alkaloids; Neutrophils; Oxidation-Reduction; Pertussis Toxin; Phosphotransferases; Protein Kinase C; Pyrimidinones; Staurosporine; Superoxides; Thiazoles; Uric Acid; Virulence Factors, Bordetella | 1991 |
A diacylglycerol kinase inhibitor, R 59 022, potentiates superoxide anion production and 46-kDa protein phosphorylation in guinea pig polymorphonuclear leukocytes.
Topics: Alkaloids; Animals; Diacylglycerol Kinase; Female; Guinea Pigs; Kinetics; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotransferases; Protein Kinase Inhibitors; Pyrimidinones; Staurosporine; Superoxides; Thiazoles | 1990 |
Role of protein kinase C in the regulation of cytosolic Ca2+ in A431 cells: separation of growth factor and bradykinin pathways.
Topics: Alkaloids; Bradykinin; Calcium; Cytosol; Down-Regulation; Epidermal Growth Factor; Humans; Ionomycin; Manganese; Protein Kinase C; Pyrimidinones; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1990 |
IL-8 enhances antibody-dependent cellular cytotoxicity in human neutrophils.
Topics: Adjuvants, Immunologic; Alkaloids; Anions; Antibody-Dependent Cell Cytotoxicity; Diacylglycerol Kinase; Humans; Interleukin-8; Neutrophil Activation; Neutrophils; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Respiratory Burst; Staurosporine; Superoxides; Thiazoles | 1995 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid.
Topics: Adenosine Diphosphate; Alkaloids; Blood Platelets; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Ethers, Cyclic; Humans; Okadaic Acid; Phosphotransferases; Platelet Aggregation; Protein Kinase C; Pyrimidinones; Serotonin; Staurosporine; Thiazoles; Thrombin; Type C Phospholipases | 1993 |
A strategy for screening anti-tumor drugs utilizing oncogenes encoded in retroviral vectors.
Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Benzamides; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Ethers, Cyclic; Genes, ras; Genes, src; Genetic Vectors; Hydroquinones; Mice; Okadaic Acid; Oncogenes; Phenols; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Retroviridae; Signal Transduction; Staurosporine; Styrenes; Sulfones; Thiazoles | 1996 |
The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.
Topics: Animals; Calcium; Carcinogens; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine; Thiazoles; Vas Deferens | 1996 |
Contribution of PKC to beta-hexosaminidase-induced airway smooth muscle proliferation.
Topics: Animals; beta-N-Acetylhexosaminidases; Cattle; Cell Count; Cell Division; Diacylglycerol Kinase; Enzyme Inhibitors; Hexosaminidase A; Insulin; Muscle, Smooth; Naphthalenes; Phenylisopropyladenosine; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Thymidine; Trachea | 1997 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
The 5-HT1A receptor agonist BAY x 3702 prevents staurosporine-induced apoptosis.
Topics: Animals; Apoptosis; Benzopyrans; Cells, Cultured; Cerebral Cortex; DNA Fragmentation; Female; Hippocampus; Neurons; Neuroprotective Agents; Piperazines; Pyridines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Thiazoles | 1998 |
Neuroprotective effects of nicergoline in immortalized neurons.
Topics: Animals; Antioxidants; Benzoquinones; Buthionine Sulfoximine; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Maleates; Neurons; Neuroprotective Agents; Nicergoline; Staurosporine; Tetrazolium Salts; Thiazoles; Ubiquinone; Vitamin E | 1999 |
Regulatory light chain phosphorylation and the assembly of myosin II into the cytoskeleton of microcapillary endothelial cells.
Topics: Actins; Adenosine Triphosphate; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Cattle; Cytochalasin D; Cytoskeleton; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Myosin Light Chains; Myosins; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Staurosporine; Thiazoles; Thiazolidines | 1999 |
Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Reductase; Animals; Benzothiazoles; Cell Line; Drug Synergism; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phthalazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles | 1999 |
S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702.
Topics: Animals; Animals, Newborn; Antibodies; Apoptosis; Astrocytes; Benzopyrans; Cell Survival; Cells, Cultured; Chick Embryo; Coculture Techniques; Corpus Striatum; Cytoprotection; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Male; Nerve Growth Factors; Neurons; Neuroprotective Agents; Piperazines; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin Antagonists; Staurosporine; Thiazoles | 2000 |
Angiotensin II does not induce apoptosis but rather prevents apoptosis in cardiomyocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; Camptothecin; Cell Nucleus; Cell Separation; Cells, Cultured; Chick Embryo; Culture Media, Serum-Free; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Heart; In Situ Nick-End Labeling; Mice; Myocardium; Necrosis; Propidium; Staurosporine; Tetrazolium Salts; Thiazoles; Time Factors | 2000 |
Wound closure in the lamellipodia of single cells: mediation by actin polymerization in the absence of an actomyosin purse string.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cytochalasin D; Enzyme Inhibitors; Humans; Microscopy, Video; Myosin Type II; Nucleic Acid Synthesis Inhibitors; Phalloidine; Pseudopodia; Sea Urchins; Staurosporine; Thiazoles; Thiazolidines | 2002 |
Respiration and mitochondrial membrane potential are not required for apoptosis and anti-apoptotic action of Bcl-2 in HeLa cells.
Topics: Antifungal Agents; Antimycin A; Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Respiration; Cytochrome c Group; Genetic Vectors; HeLa Cells; Humans; Membrane Potentials; Methacrylates; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Rotenone; Signal Transduction; Staurosporine; Thiazoles; Transfection; Uncoupling Agents | 2002 |
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Culture Media; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Humans; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Mutation; Neurons; Oxidative Stress; PC12 Cells; Rats; Staurosporine; Tetrazolium Salts; Thiazoles | 2002 |
The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.
Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cells, Cultured; Dimerization; Enzyme Inhibitors; Fibroblasts; Gene Expression; Humans; Kidney; Membrane Proteins; Mice; Peptide Fragments; Phenotype; Presenilin-2; Protein Structure, Tertiary; Staurosporine; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2003 |
Involvement of actin polymerization in vesicle recruitment at the calyx of Held synapse.
Topics: Actins; Adenosine Triphosphate; Animals; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Enzyme Inhibitors; Ethylmaleimide; In Vitro Techniques; Macromolecular Substances; N-Ethylmaleimide-Sensitive Proteins; Patch-Clamp Techniques; Phalloidine; Presynaptic Terminals; Protein Kinase Inhibitors; Rats; Rats, Wistar; Staurosporine; Synapses; Synaptic Transmission; Synaptic Vesicles; Thiazoles; Thiazolidines; Vesicular Transport Proteins | 2003 |
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Topics: Apoptosis; Bisbenzimidazole; Blotting, Western; Carbon-Sulfur Lyases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Genetic Therapy; Humans; Lung Neoplasms; Mitochondria; Models, Biological; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pseudomonas putida; Selenomethionine; Staurosporine; Tetrazolium Salts; Thiazoles; Transfection | 2003 |
Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Aminobenzoates; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Benzothiazoles; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Heart; Heart Atria; Imines; Indoles; Isoquinolines; Ketanserin; Male; Myocytes, Cardiac; Neomycin; para-Aminobenzoates; Perfusion; Phenanthridines; Piperazines; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Sulfonamides; Thiazoles; Type C Phospholipases | 2003 |
Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis.
Topics: Adenine; Allopurinol; Animals; Antioxidants; Apoptosis; Arachidonic Acids; Benzoquinones; Blotting, Western; Calcium; Carbon; Caspase 3; Caspases; Cell Death; Cell Survival; Chick Embryo; Chromans; Coloring Agents; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Glutathione; In Situ Nick-End Labeling; Indazoles; Metalloporphyrins; Mitochondria; Neurons; Nitric Oxide Synthase; Oligomycins; Protein Isoforms; Reactive Oxygen Species; Retina; Rotenone; Staurosporine; Tetrazolium Salts; Thiazoles; Time Factors; Ubiquinone; Uncoupling Agents; Xanthine Oxidase | 2003 |
Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carrier Proteins; Caspase 2; Caspase 3; Caspase 7; Caspase 8; Caspases; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Etoposide; Gene Silencing; Humans; Membrane Glycoproteins; Mitochondria; Models, Biological; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Staurosporine; Tetrazolium Salts; Thiazoles; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha | 2004 |
Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.
Topics: Animals; Antimetabolites; Antioxidants; Apoptosis; Bisbenzimidazole; Buthionine Sulfoximine; Carcinogens; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Fluorescent Dyes; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Neostriatum; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Staurosporine; Tetrazolium Salts; Thiazoles; Tocotrienols; Vitamin E | 2004 |
Modification of physicochemical properties of actin filaments suppresses cell fragmentation in the execution phase of staurosporine-induced apoptotic processes.
Topics: Actin Cytoskeleton; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspases; Cell Line, Tumor; Depsipeptides; Enzyme Inhibitors; Humans; Immunoblotting; Membrane Potentials; Microscopy, Confocal; Mitochondria; Staurosporine; Thiazoles; Thiazolidines | 2004 |
Non-equilibration of hydrostatic pressure in blebbing cells.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Surface Extensions; Cytoplasm; Cytoskeleton; Elasticity; Hydrostatic Pressure; Microscopy, Video; Models, Biological; Movement; Perfusion; Staurosporine; Thiazoles; Thiazolidines; Time Factors | 2005 |
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; DNA; DNA Mutational Analysis; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Gene Duplication; Gene Rearrangement; Humans; Immunoprecipitation; In Situ Hybridization, Fluorescence; Infant; Infant, Newborn; Ligands; Mutation; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Analysis, DNA; Staurosporine; Tetrazolium Salts; Thiazoles | 2005 |
Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions.
Topics: Animals; Calcium; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Membrane Potentials; Minocycline; Mitochondria; Mitochondrial Swelling; NADP; Neuroblastoma; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spectrophotometry; Staurosporine; Tetrazolium Salts; Thiazoles | 2005 |
Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Apoptosis; Aspartic Acid Endopeptidases; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Chromatin; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoprecipitation; Luciferases; Membrane Proteins; Multiprotein Complexes; Mutation; Neuroblastoma; Peptide Fragments; Presenilin-1; Protein Structure, Tertiary; Staurosporine; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Transfection | 2006 |
Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; DNA, Neoplasm; Drug Combinations; Enzyme Inhibitors; Epithelial Cells; Female; HeLa Cells; Humans; Membrane Potentials; Membrane Proteins; Mitochondria; Mutation; Nerve Tissue Proteins; Papillomaviridae; Staurosporine; Thiazoles; Toluene; Transcription, Genetic; Tumor Suppressor Protein p53 | 2006 |
A novel N-alkylated prodigiosin analogue induced death in tumour cell through apoptosis or necrosis depending upon the cell type.
Topics: Alkenes; Alkylation; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Dactinomycin; Diploidy; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Lymphoma, T-Cell; Mice; Necrosis; Prodigiosin; Pyrroles; Rats; Sarcoma 180; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant of KIT.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Survival; Dasatinib; Drug Synergism; Humans; Mast Cells; Mastocytosis, Systemic; Mutation, Missense; Neoplasm Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Thiazoles | 2007 |
Profound inhibition of antigen-specific T-cell effector functions by dasatinib.
Topics: Apoptosis; Cells, Cultured; Dasatinib; Dose-Response Relationship, Drug; Humans; Immunologic Memory; Interleukin-2; Lymphocyte Activation; Protein Kinase Inhibitors; Pyrimidines; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Thiazoles | 2008 |
Lumican affects actin cytoskeletal organization in human melanoma A375 cells.
Topics: Actins; Apoptosis; Blotting, Western; Cell Survival; Chondroitin Sulfate Proteoglycans; Collagen; Cytoskeleton; Cytosol; Fibronectins; Humans; Isomerism; Keratan Sulfate; Lumican; Melanoma; Microscopy, Confocal; Microscopy, Fluorescence; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Cell Count; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Enzyme Inhibitors; Glutamic Acid; Microglia; Neurons; Rats; Rats, Wistar; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin | 2008 |
Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor.
Topics: Adenosine Triphosphate; Animals; Calcium; Caspases; Cell Death; Cell Differentiation; Cells, Cultured; Chelating Agents; Corpus Striatum; Egtazic Acid; Embryo, Mammalian; Embryonic Stem Cells; Enzyme Inhibitors; Extracellular Fluid; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neurons; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Staurosporine; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation.
Topics: Animals; Apoptosis; Base Sequence; Benzamides; Cat Diseases; Cats; Cell Proliferation; Dasatinib; DNA Primers; Exons; Female; Humans; Imatinib Mesylate; In Vitro Techniques; Male; Mast Cells; Mastocytosis, Systemic; Molecular Sequence Data; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Tandem Repeat Sequences; Thiazoles | 2009 |
Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
Topics: Benzamides; Binding Sites; Carbazoles; Computer Simulation; Dasatinib; Drug Design; Furans; Humans; Hydrogen Bonding; Imatinib Mesylate; Indoles; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Sunitinib; Thiazoles | 2010 |
H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cats; Cell Line, Tumor; Cell Proliferation; Dasatinib; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Histamine H1 Antagonists, Non-Sedating; Humans; Inhibitory Concentration 50; Loratadine; Mastocytoma; Mastocytosis, Systemic; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Terfenadine; Thiazoles; Tumor Cells, Cultured | 2010 |
Systemic mastocytosis in adults: 2011 update on diagnosis, risk stratification, and management.
Topics: Adult; Antineoplastic Agents; Benzamides; Bone Marrow; Cladribine; Dasatinib; Disease-Free Survival; Humans; Hydroxyurea; Imatinib Mesylate; Interferon Type I; Mast Cells; Mastocytosis, Systemic; Piperazines; Point Mutation; Proto-Oncogene Proteins c-kit; Pyrimidines; Recombinant Proteins; Risk; Staurosporine; Thiazoles | 2011 |
Dasatinib, imatinib and staurosporine capture compounds - Complementary tools for the profiling of kinases by Capture Compound Mass Spectrometry (CCMS).
Topics: Benzamides; Chromatography, Liquid; Dasatinib; Gene Expression Profiling; Hep G2 Cells; Humans; Imatinib Mesylate; Liver Neoplasms; Mass Spectrometry; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Pyrimidines; Staurosporine; Thiazoles | 2011 |
KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib.
Topics: Agammaglobulinaemia Tyrosine Kinase; Aniline Compounds; Cell Line, Tumor; Dasatinib; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Mast Cells; Mastocytosis, Systemic; Mutation; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Quinolines; Signal Transduction; src-Family Kinases; Staurosporine; Thiazoles; Tumor Cells, Cultured | 2011 |
Cellular imaging assay for early evaluation of an apoptosis inducer.
Topics: Annexin A5; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cytological Techniques; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Microscopy, Confocal; Phosphatidylserines; Staurosporine; Surface Plasmon Resonance; Tetrazolium Salts; Thiazoles | 2011 |
Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase.
Topics: Animals; Benzamides; Benzenesulfonates; Binding, Competitive; Cell Line; Dasatinib; Dose-Response Relationship, Drug; Humans; Imatinib Mesylate; Indazoles; Indoles; Kinetics; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Sorafenib; Spodoptera; Staurosporine; Sulfonamides; Sunitinib; Surface Plasmon Resonance; Thiazoles; Transfection | 2012 |
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Stability; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Thiazoles; Tyrosine; Up-Regulation | 2011 |
Off-target immune cell toxicity caused by AG-012986, a pan-CDK inhibitor, is associated with inhibition of p38 MAPK phosphorylation.
Topics: Apoptosis; Benzamides; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Cytotoxins; Humans; Inhibitory Concentration 50; Interleukin-2; Leukocytes, Mononuclear; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Staurosporine; Thiazoles | 2012 |
Targeting sphingosine kinase-1 to inhibit melanoma.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Humans; Lysophospholipids; Melanocytes; Melanoma; Mice; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; RNA, Small Interfering; Skin Neoplasms; Sphingosine; Staurosporine; Thiazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Janus Kinases; Leukemia, Myeloid, Acute; Mice; Mutation; Protein Kinase Inhibitors; Pyrimidines; STAT5 Transcription Factor; Staurosporine; Stromal Cells; Thiazoles | 2012 |
New indolocarbazoles from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Marine Biology; Molecular Structure; Protein Kinase C-alpha; Staurosporine; Streptomyces; Thiazoles | 2012 |
Rapid screening of potential autophagic inductor agents using mammalian cell lines.
Topics: Animals; Autophagy; Cell Line; Cell Survival; Drug Discovery; Gentian Violet; Humans; Hydrogen Peroxide; Indicators and Reagents; Mice; Microscopy, Fluorescence; Neutral Red; Reproducibility of Results; Statistics, Nonparametric; Staurosporine; Tetrazolium Salts; Thiazoles | 2013 |
Familial systemic mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib, dasatinib and PKC412.
Topics: Adult; Apoptosis; Base Sequence; Benzamides; Blotting, Western; Dasatinib; Female; Germ-Line Mutation; Humans; Imatinib Mesylate; Mastocytosis, Systemic; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Thiazoles; Young Adult | 2014 |
IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Brentuximab Vedotin; Cell Line, Tumor; Cytokines; Dog Diseases; Dogs; Down-Regulation; Drug Synergism; Female; Immunoconjugates; Interleukin-4; Ki-1 Antigen; Male; Mastocytosis; Piperidines; Pyridines; Staurosporine; Thiazoles | 2017 |
Camalexin-Induced Cell Membrane Scrambling and Cell Shrinkage in Human Erythrocytes.
Topics: Benzophenanthridines; Calcium; Caspase Inhibitors; Cell Size; Ceramides; Cytosol; Eryptosis; Erythrocyte Membrane; Erythrocytes; Hemolysis; Humans; Indoles; Oligopeptides; Phosphatidylserines; Reactive Oxygen Species; Staurosporine; Thiazoles | 2017 |
In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.
Topics: Benzamides; Benzimidazoles; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Indoles; Inhibitory Concentration 50; Microsomes, Liver; Phthalazines; Piperidines; Pyridines; Pyridones; Pyrimidinones; Quinolones; Staurosporine; Thiazoles | 2018 |
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
Topics: Acetic Acid; Acetone; Cells, Cultured; Drug Discovery; Drug Evaluation, Preclinical; Ethanol; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; HSP90 Heat-Shock Proteins; Humans; Methotrexate; NADH Dehydrogenase; Oxazoles; Proteomics; Solvents; Staurosporine; Thiazoles | 2020 |