staurosporine has been researched along with thapsigargin in 109 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.92) | 18.7374 |
| 1990's | 56 (51.38) | 18.2507 |
| 2000's | 43 (39.45) | 29.6817 |
| 2010's | 9 (8.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alkhalaf, B; Ballejo, G; Gong, Y; Molnar, P; Murphy, LC; Murphy, LJ | 1 |
| Balla, T; Catt, KJ; Clark, AJ; Jones, MR | 1 |
| Gilfillan, AM; Lin, P | 1 |
| Fabbro, D; Jaken, S; Kiley, SC; Parker, PJ | 1 |
| Alkhalaf, B; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Crichton, CA; Currie, S; Hallam, C; Jackson, CG; Smith, GL; Wakelam, MJ | 1 |
| Johnson, AL; Tilly, JL | 1 |
| Fujiki, H; Hirota, M; Suganuma, M; Sugimura, T; Suguri, H; Takagi, K; Yoshizawa, S | 1 |
| De Pont, JJ; Van Emst-de Vries, SE; Willems, PH | 1 |
| Schiffrin, EL; Tolloczko, B; Touyz, RM | 1 |
| Matsui, S; Matsumoto, Y; Tanimura, A; Tojyo, Y | 1 |
| Balasubramaniam, R; Collingridge, GL; Harvey, J | 1 |
| Thurston, G; Turner, D | 1 |
| Aviv, A; Cho, JH; Kimura, M; Reeves, JP | 1 |
| Durand, J; Marmy, N | 1 |
| Matsumoto, Y; Sugiya, H; Tanimura, A; Tojyo, Y | 1 |
| Goshima, Y; Li, L; Strittmatter, SM; Xie, R | 1 |
| Reich, H; Sei, Y | 1 |
| Akaike, N; Uneyama, C; Uneyama, H | 1 |
| Goetz, FW | 1 |
| Distler, A; Haller, H; Lindschau, C; Luft, FC; Quass, P | 1 |
| Foder, B; Scharff, O | 1 |
| Blok, LJ; Gong, Y; Lindzey, JK; Perry, JE; Tindall, DJ | 1 |
| Dohi, T; Kitayama, S; Morita, K; Okamoto, H; Shibata, K; Shirakawa, M | 1 |
| Bissonnette, M; Brasitus, TA; Khare, S; Tien, XY; Wali, RK; Wilson, DM | 1 |
| Conroy, LA; Hallam, TJ; Merritt, JE | 1 |
| Bode, HP; Fehmann, HC; Göke, B; Williams, JA; Yule, DI | 1 |
| Alexandre, A; Cavallini, L | 1 |
| Bode, HP; Göke, B | 1 |
| Benistant, C; Gustavsson, L; Hoek, JB; Moehren, G; Rubin, R; Torres-Marquez, ME | 1 |
| Bortolotto, ZA; Collingridge, GL | 1 |
| Casteels, R; De Smedt, H; Himpens, B | 1 |
| Egashira, K; Fukumoto, Y; Ito, A; Kadokami, T; Shimokawa, H; Takayanagi, T; Takeshita, A | 1 |
| Dohi, T; Kitayama, S; Morita, K; Okamoto, H; Shibata, K | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A | 1 |
| Akaike, N; Takahashi, M; Uneyama, C; Uneyama, H | 1 |
| Balasubramanyam, M; Gardner, JP | 1 |
| Ahnadi, CE; Dupuis, G; Payet, MD | 1 |
| Collyn, L; Dumont, JE; Lejeune, C; Mockel, J; Rocmans, P; Taton, M | 1 |
| Descomps, B; Lobaccaro-Henri, C; Thaler-Dao, H | 1 |
| Keiser, HR; Oriji, GK | 1 |
| Cousin, JM; Haslett, C; Rossi, AG | 1 |
| Baker, A; Briehl, MM; Payne, CM; Powis, G | 1 |
| Benton, HP; Koolpe, M; Rodrigo, JJ | 1 |
| Gnegy, ME; McGinnis, KM; Wang, KK; Whitton, MM | 1 |
| Ivey, CL; Roy, BJ; Townsley, MI | 1 |
| Cohen, GM; Gescher, A; Harkin, ST | 1 |
| Chin, TY; Chueh, SH | 2 |
| Kim, YJ; Lee, SI; Seo, JT; Shin, DM | 1 |
| Ambudkar, IS; Liu, X; O'Connell, A | 1 |
| Hayashi, K; Okada, H; Ozawa, Y; Saruta, T; Suzuki, H; Takenaka, T | 1 |
| Hrelia, S; Orlati, S; Porcelli, AM; Rugolo, M | 1 |
| Daniel, WG; Garlichs, CD; Mügge, A; Zhang, H | 1 |
| Dugué, B; Titievsky, A; Törnquist, K; Tuominen, R; Vainio, P | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Greger, R; Henger, A; Mundel, P; Nitschke, R; Pavenstädt, H; Rüdiger, F | 1 |
| Florio, T; Giordano, G; Giusti, M; Schettini, G; Thellung, S; Valenti, S | 1 |
| Dartt, DA; Hodges, RR; Sergheraert, C; Zoukhri, D | 1 |
| Drexler, HG; Meyer, C; Steube, KG | 1 |
| Cruzblanca, H; Hille, B; Kaftan, EJ; Mackie, K; Roche, JP; Shapiro, MS | 1 |
| Hayden, MR; Mujumdar, VS; Tyagi, SC | 1 |
| Fujita, H; Koya, RC; Kuzumaki, N; Ohtsu, M; Shimizu, S; Takimoto, M; Tsujimoto, Y | 1 |
| Korhonen, L; Kukkonen, JP; Lindholm, D; Mercer, EA; Olsson, PA; Skoglösa, Y | 1 |
| Bleackley, RC; Bossy-Wetzel, E; Burns, K; Fadel, MP; Goping, IS; Green, DR; Lozyk, M; Michalak, M; Nakamura, K; Opas, M | 1 |
| Björklund, S; Dugué, B; Titievsky, A; Törnquist, K; Tuominen, RK; Vainio, PJ | 1 |
| Billardon, C; Carvajal-Gonzalez, S; Gompel, A; Kandouz, M; Lombet, A; Rostène, W; Zujovic, V | 1 |
| Bungard, D; Lytton, J; Wu, KD | 1 |
| Blauvelt, A; Davis, DA; Moses, AV; Orenstein, JM; Overwijk, WW; Rinderknecht, AS; Yarchoan, R; Zoeteweij, JP | 1 |
| Adams, ME; Cardullo, RA; Kingan, TG | 1 |
| Distelhorst, CW; Heiskanen, K; McColl, KS; Thomenius, MJ; Unkila, M | 1 |
| Briehl, MM; Tome, ME | 1 |
| Nguyen, HN; Perry, DC; Wang, C | 1 |
| Albertioni, F; Chandra, J; Gogvadze, V; Kaufmann, SH; Mansson, E; Orrenius, S | 1 |
| Bakowski, D; Glitsch, MD; Parekh, AB | 1 |
| Chinnadurai, G; Lomonosova, E; Theodorakis, P | 1 |
| Hori, O; Kitao, Y; Matsushita, K; Matsuyama, T; Miyazaki, M; Ogawa, S; Ozawa, K | 1 |
| Elia, MG; Greco, S; Marsigliante, S; Muscella, A; Salvatore, P; Storelli, C | 1 |
| Ban, HS; Kim, YP; Lee, S; Ohuchi, K; Shin, KH; Yamaki, K | 1 |
| Kitani, S; Morita, Y; Nakamura, R; Sasaki, N; Sato, Y; Sawada, J; Teshima, R | 1 |
| Benjamins, JA; George, EB; Nedelkoska, L | 1 |
| Challiss, RA; Nahorski, SR; Nash, MS; Young, KW | 1 |
| Baldwin, J; Bousquet, P; Chen, M; Dontenwill, M; Dupuy, L; Greney, H; Pascal, G; Piletz, JE; Rondé, P; Takeda, K; Urosevic, D | 1 |
| Chodosh, LA; Cinalli, RM; Fox, CJ; Hammerman, PS; Master, SR; Thompson, CB | 1 |
| Davis, S; Kermer, P; Krajewska, M; Krajewski, S; Reed, JC; Roth, W; Welsh, K | 1 |
| Fabbro, M; Nair, SV; Raftos, DA | 1 |
| Collett, VJ; Collingridge, GL | 1 |
| De Mello, WC; Monterrubio, J | 1 |
| Bristulf, J; Owman, C; Sabirsh, A | 1 |
| Hayashi, K; Homma, K; Kanda, T; Kumagai, H; Okubo, K; Ozawa, Y; Saruta, T; Takamatsu, I; Tatematsu, S; Wakino, S | 1 |
| Brasolin, A; Hirata, H; Lopes, GS; Machado, LS; Okuno, CS; Smaili, SS | 1 |
| Edwards, JM; Kempson, SA; Sturek, M | 1 |
| Concannon, CG; Gorman, AM; Ní Chonghaile, T; Samali, A; Szegezdi, E | 1 |
| Benjamins, JA; Nedelkoska, L | 1 |
| Oh, YS; Park, SC; Ryu, SJ | 1 |
| Assefa, Z; Bultynck, G; Callewaert, G; De Smedt, H; Fissore, RA; Kocks, SL; Lee, B; Missiaen, L; Parys, JB; Verbert, L | 1 |
| Hirata, Y; Kiuchi, K; Oh-hashi, K; Tsuruta, T | 1 |
| Armstrong, EJ; Hemendinger, RA; Mougeot, JL; Persinski, R; Rosenfeld, J; Todd, J; Volvovitz, F | 1 |
| An, HJ; Choi, HR; Ha, MK; Oh, YS; Park, SC; Ryu, SJ | 1 |
| Cheng, EH; Hsieh, JJ; Jeffers, JR; Kim, H; Ren, D; Takeuchi, O; Tu, HC; Zambetti, GP | 1 |
| Aberg, AM; Haney, M; Ronquist, G; Waldenstrom, A | 1 |
| Alcorn, JF; Anathy, V; Dienz, O; Godburn, KE; Guala, AS; Janssen-Heininger, YM; Pociask, DA; Reiss, JN; Riches, DW; Roberson, EC; Tully, JE | 1 |
| Ao, Z; Choi, WS; Kim, SJ; McIntosh, CH; Nian, C; Warnock, G; Widenmaier, SB | 1 |
| Armstrong, EJ; Brooks, BR; Hemendinger, RA; Radio, N | 1 |
| Cardullo, RA; Haimo, LT; Miyata, H; Thaler, CD | 1 |
| Gadet, R; Gillet, G; Gonzalo, P; Hesling, C; Lopez, J; Mikaelian, I; Popgeorgiev, N; Prudent, J; Rimokh, R | 1 |
| Casanelles, E; Garcia-Belinchón, M; Granados-Colomina, C; Iglesias-Guimarais, V; Martínez-Escardó, L; Pascual-Guiral, S; Ribas, J; Sánchez-Osuna, M; Yuste, VJ | 1 |
| Barbieri, E; D'Alonzo, D; Frank, S; Licci, M; Oettinghaus, B; Restelli, LM; Savoia, C; Scorrano, L; Tolnay, M | 1 |
| Kim, BJ; Kim, JN | 1 |
109 other study(ies) available for staurosporine and thapsigargin
| Article | Year |
|---|---|
Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Calcimycin; Carrier Proteins; Cell Division; Cycloheximide; Endometrial Neoplasms; Enzyme Activation; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor Binding Proteins; Kinetics; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1992 |
Stimulation of early gene expression by angiotensin II in bovine adrenal glomerulosa cells: roles of calcium and protein kinase C.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adrenocorticotropic Hormone; Alkaloids; Angiotensin II; Animals; Base Sequence; Calcium; Cattle; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Genes, fos; Genes, jun; Imidazoles; Ionomycin; Molecular Sequence Data; Protein Kinase C; Pyridines; Staurosporine; Stimulation, Chemical; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Zona Glomerulosa | 1992 |
The role of calcium and protein kinase C in the IgE-dependent activation of phosphatidylcholine-specific phospholipase D in a rat mast (RBL 2H3) cell line.
Topics: Alkaloids; Animals; Calcium; Cell Line; Enzyme Activation; Histamine Release; Immunoglobulin E; Indoles; Ionomycin; Kinetics; Maleimides; Mast Cells; Phospholipase D; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine.
Topics: Alkaloids; Animals; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Phorbol 12,13-Dibutyrate; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Staurosporine; Terpenes; Thapsigargin | 1992 |
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cycloheximide; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein A6; S100 Proteins; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Uterine Neoplasms | 1992 |
Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bombesin; Calcium; Calcium-Transporting ATPases; Carbon Radioisotopes; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolysis; Kinetics; Lysophosphatidylcholines; Mice; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Second messenger pathways mediating chicken luteinizing hormone secretion from dispersed pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Chickens; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Pituitary Gland; Protein Kinase C; Second Messenger Systems; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transforming Growth Factor alpha | 1991 |
Diversity in the chemical nature and mechanism of response to tumor promoters.
Topics: Acrylamides; Alkaloids; Animals; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Cnidarian Venoms; Enzyme Induction; Ethers, Cyclic; Mice; Okadaic Acid; Ornithine Decarboxylase; Plant Extracts; Plants, Medicinal; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Vasoconstrictor Agents | 1989 |
Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Amylases; Animals; Calcium-Transporting ATPases; Cells, Cultured; Cholecystokinin; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Pancreas; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Sincalide; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors | 1995 |
Insulin attenuates agonist-evoked calcium transients in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Diltiazem; Fluorescent Dyes; Fura-2; Humans; Insulin; Mesenteric Arteries; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Staurosporine; Terpenes; Thapsigargin | 1994 |
Carbachol-induced potassium release in rat parotid acini: comparison of the roles of cytosolic Ca2+ and protein kinase C.
Topics: Alkaloids; Amylases; Animals; Calcium; Calcium Channel Blockers; Carbachol; Cytosol; Egtazic Acid; Enzyme Activation; Gallic Acid; Ionomycin; Male; Parotid Gland; Potassium; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1993 |
Carbachol can potentiate N-methyl-D-aspartate responses in the rat hippocampus by a staurosporine and thapsigargin-insensitive mechanism.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Drug Synergism; Female; Hippocampus; In Vitro Techniques; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Muscarinic; Staurosporine; Terpenes; Tetrodotoxin; Thapsigargin | 1993 |
Thrombin-induced increase of F-actin in human umbilical vein endothelial cells.
Topics: Actins; Alkaloids; Calcium; Capillary Permeability; Cells, Cultured; Cytoskeleton; Diterpenes; Endothelium, Vascular; Humans; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Umbilical Veins | 1994 |
Inhibition of Ca2+ entry by Ca2+ overloading of intracellular Ca2+ stores in human platelets.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Blood Platelets; Calcium; Calcium Channels; Carrier Proteins; Cell Membrane Permeability; Cricetinae; Fura-2; Humans; Inositol 1,4,5-Trisphosphate; Naphthalenes; Ouabain; Polycyclic Compounds; Protein Kinase C; Sodium; Sodium-Calcium Exchanger; Staurosporine; Terpenes; Thapsigargin; Thrombin | 1994 |
Control of inositol phosphate turnover in human airways during histamine stimulation.
Topics: Alkaloids; Cells, Cultured; Chromatography, High Pressure Liquid; DNA; Histamine; Histamine Release; Humans; Inositol Phosphates; Muscle, Smooth; Protein Kinase C; Respiratory System; Staurosporine; Stimulation, Chemical; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Staurosporine enhances Ca2+ entry induced by depletion of intracellular Ca2+ stores in rat parotid acinar cells.
Topics: Alkaloids; Animals; Calcium; Calcium-Transporting ATPases; Carbachol; Enzyme Inhibitors; In Vitro Techniques; Intracellular Fluid; Ion Transport; Ionomycin; Ionophores; Male; Manganese; Muscarinic Agonists; Parotid Gland; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Terpenes; Thapsigargin | 1995 |
An activated mutant of the alpha subunit of G(o) increases neurite outgrowth via protein kinase C.
Topics: Alkaloids; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Gallic Acid; GTP-Binding Proteins; Mutation; Neurites; Okadaic Acid; PC12 Cells; Protein Kinase C; Rats; Second Messenger Systems; Staurosporine; Terpenes; Thapsigargin; Transfection | 1995 |
Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Calcimycin; Calcium; Calcium-Transporting ATPases; Cholera Toxin; Colforsin; Drug Synergism; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Isoquinolines; Leukemia-Lymphoma, Adult T-Cell; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Involvement of protein kinase C in agonist-stimulated goldfish ovulation.
Topics: Alkaloids; Animals; Calcimycin; Dinoprost; Female; Goldfish; Hydrogen-Ion Concentration; In Vitro Techniques; Naphthalenes; Ovulation; Polycyclic Compounds; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vanadates | 1993 |
Nuclear calcium signaling is initiated by cytosolic calcium surges in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; Ionomycin; Isoquinolines; Kinetics; Microscopy, Confocal; Muscle, Smooth, Vascular; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Second Messenger Systems; Signal Transduction; Staurosporine; Terpenes; Thapsigargin | 1994 |
Delayed activation of plasma membrane Ca2+ pump in human neutrophils.
Topics: Adenosine Triphosphate; Alkaloids; Biological Transport; Calcium; Calcium Channels; Calcium Chloride; Calcium-Transporting ATPases; Calmodulin; Cations, Divalent; Cell Membrane Permeability; Choline; Culture Media; Cytosol; Econazole; Egtazic Acid; Humans; Ionomycin; Monensin; Neutrophils; Protein Kinase C; Staurosporine; Sulfonamides; Terpenes; Thapsigargin | 1994 |
Calcium regulation of androgen receptor expression in the human prostate cancer cell line LNCaP.
Topics: Alkaloids; Apoptosis; Blotting, Northern; Blotting, Western; Calcimycin; Calcium; Calcium-Transporting ATPases; Cell Line; Cell Nucleus; Dactinomycin; Dose-Response Relationship, Drug; Gene Expression; Humans; Kinetics; Male; Prostatic Neoplasms; Protein Kinase C; Receptors, Androgen; RNA, Messenger; RNA, Neoplasm; Staurosporine; Terpenes; Thapsigargin; Tumor Cells, Cultured | 1995 |
Regulation by protein kinase C of platelet-activating factor- and thapsigargin-induced calcium entry in rabbit neutrophils.
Topics: Alkaloids; Animals; Calcium; Calcium Chloride; Calcium-Transporting ATPases; Cytosol; Electrophysiology; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Spectrometry, Fluorescence; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Protein kinase C mediates the calcium-induced activation of rat colonic particulate guanylate cyclase.
Topics: Alkaloids; Animals; Calcium; Colon; Enzyme Activation; Estrenes; Guanylate Cyclase; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Regulation of T-cell-receptor-stimulated bivalent-cation entry in Jurkat E6 cells: role of protein kinase C.
Topics: Alkaloids; Antibodies, Monoclonal; Antigen-Antibody Complex; Calcium; CD3 Complex; Cell Line; Enzyme Activation; Fura-2; Indoles; Maleimides; Manganese; Protein Kinase C; Receptors, Antigen, T-Cell; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Spontaneous calcium oscillations in clonal endocrine pancreatic glucagon-secreting cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Calcium; Cell Line; Cyclic GMP; Estrenes; Glucagon; Pancreas; Protein Kinase C; Pyrrolidinones; Staurosporine; Terpenes; Thapsigargin; Type C Phospholipases | 1994 |
Ca2+ efflux from platelets. Control by protein kinase C and the filling state of the intracellular Ca2+ stores.
Topics: Alkaloids; Blood Platelets; Calcium; Calcium Radioisotopes; Calcium-Transporting ATPases; Cytoplasmic Granules; Cytosol; Dose-Response Relationship, Drug; Egtazic Acid; Exocytosis; Fluorescent Dyes; Humans; In Vitro Techniques; Indoles; Ionomycin; Kinetics; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin | 1994 |
Protein kinase C activates capacitative calcium entry in the insulin secreting cell line RINm5F.
Topics: Alkaloids; Animals; Biological Transport; Calcium; Cytosol; Insulin; Insulin Secretion; Insulinoma; Manganese; Pancreatic Neoplasms; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1994 |
The role of cytosolic Ca2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Ethers, Cyclic; Glycerophospholipids; Isoquinolines; Liver; Male; Okadaic Acid; Phosphatidic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasopressins | 1994 |
Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus.
Topics: Alkaloids; Animals; Calcium-Transporting ATPases; Cycloleucine; Electric Stimulation; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Phosphatidylinositols; Protein Kinase C; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Staurosporine; Stereoisomerism; Synapses; Terpenes; Thapsigargin | 1993 |
Staurosporine induced Ca2+ increase in DDT1MF-2 smooth muscle cells.
Topics: Alkaloids; Animals; Calcium; Calcium-Transporting ATPases; Cell Nucleus; Cricetinae; Cytoplasm; Down-Regulation; Fluorescence; Leiomyosarcoma; Male; Mesocricetus; Muscle, Smooth; Neoplasms, Muscle Tissue; Phorbol Esters; Protein Kinase C; Sarcoplasmic Reticulum; Staurosporine; Terpenes; Thapsigargin; Tumor Cells, Cultured | 1993 |
Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Coronary Vasospasm; Cytosol; Enzyme Activation; Histamine; Interleukin-1; Male; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Ryanodine; Sarcoplasmic Reticulum; Serotonin; Sphingosine; Staurosporine; Swine; Terpenes; Thapsigargin | 1996 |
Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils.
Topics: Adrenal Glands; Alkaloids; Animals; Azepines; Calcium; Calcium Channel Blockers; Cattle; Chromaffin Granules; Enzyme Inhibitors; Imidazoles; Ion Transport; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Triazoles | 1996 |
Tyrosine kinase is involved in angiotensin II-stimulated phospholipase D activation in aortic smooth muscle cells: function of Ca2+ influx.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Choline; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Genistein; Inositol Phosphates; Ionophores; Isoflavones; Membrane Lipids; Muscle Proteins; Muscle, Smooth, Vascular; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Pharmacological studies on mechanisms involved in Ca2+ oscillations in rat megakaryocytes.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Female; Indoles; Male; Megakaryocytes; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Protein kinase C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells.
Topics: Alkaloids; Calcium; Calcium-Transporting ATPases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Ionomycin; Ionophores; Lanthanum; Leukemia; Naphthalenes; Phorbol Esters; Protein Kinase C; Sodium; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1995 |
Effects of staurosporine on the capacitative regulation of the state of the Ca2+ reserves in activated Jurkat T lymphocytes.
Topics: Antibodies, Monoclonal; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability; Chelating Agents; Computer Simulation; Econazole; Egtazic Acid; Enzyme Inhibitors; Fura-2; Humans; Jurkat Cells; Kinetics; Lymphocyte Activation; Models, Immunological; Nickel; Protein Kinase C; Receptors, Antigen, T-Cell, alpha-beta; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Regulation and metabolic role of phospholipase D activity in human thyroid and cultured dog thyrocytes.
Topics: Adenosine Triphosphate; Animals; Calcimycin; Calcium-Transporting ATPases; Cells, Cultured; Cytidine Monophosphate; Dogs; Enzyme Inhibitors; Glycerophospholipids; Humans; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Staurosporine; Thapsigargin; Thyroid Gland; Thyrotropin; Tritium | 1996 |
RU 38486 inhibits intracellular calcium mobilization and PGI2 release from human myometrium: mechanisms of action.
Topics: 6-Ketoprostaglandin F1 alpha; Abortifacient Agents, Steroidal; Arginine Vasopressin; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Drug Synergism; Endoplasmic Reticulum; Enzyme Inhibitors; Epoprostenol; Female; Gallic Acid; Hormone Antagonists; Humans; Intracellular Fluid; Mifepristone; Muscle Relaxation; Myometrium; Nifedipine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Staurosporine; Structure-Activity Relationship; Thapsigargin; Uterine Contraction | 1996 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin | 1997 |
Regulation of granulocyte apoptosis by PKC inhibition and elevation of [Ca2+]i.
Topics: Apoptosis; Calcimycin; Calcium; Cells, Cultured; Enzyme Inhibitors; Eosinophils; Humans; Indoles; Kinetics; Neutrophils; Protein Kinase C; Staurosporine; Thapsigargin | 1997 |
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.
Topics: Animals; Apoptosis; Dexamethasone; DNA, Complementary; Enzyme Inhibitors; Humans; Mice; Mice, SCID; Neoplasm Proteins; Sphingosine; Staurosporine; Thapsigargin; Thioredoxins; Transfection; Tumor Cells, Cultured | 1997 |
Adenosine 5'-triphosphate, uridine 5'-triphosphate, bradykinin, and lysophosphatidic acid induce different patterns of calcium responses by human articular chondrocytes.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Calcium-Binding Proteins; Cartilage, Articular; Chondrocytes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Interleukin-1; Ligands; Lysophospholipids; Purinergic Agonists; Receptors, Cell Surface; Recombinant Proteins; Sphingosine; Staurosporine; Thapsigargin; Uridine Triphosphate | 1998 |
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Caspase 3; Caspases; Chlorobenzoates; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Mice; Neuroblastoma; Peptide Fragments; Recombinant Proteins; Staurosporine; Thapsigargin; Tumor Cells, Cultured | 1998 |
Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca2+ signaling.
Topics: Alkaloids; Angiotensin II; Animals; Benzophenanthridines; Calcimycin; Calcium; Capillary Permeability; Cardiac Output, Low; Cardiac Pacing, Artificial; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Ionophores; Lung; Phenanthridines; Protein Kinase C; Signal Transduction; Staurosporine; Thapsigargin; Vascular Resistance | 1998 |
Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.
Topics: Alkaloids; Animals; Apoptosis; Benzimidazoles; Cell Death; Cell Size; Cell Survival; Cells, Cultured; DNA; Enzyme Inhibitors; Flow Cytometry; Male; Nucleic Acid Conformation; Phenotype; Protein Kinase C; Rats; Rats, Inbred F344; Staurosporine; Thapsigargin; Thymus Gland | 1998 |
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway.
Topics: Adenosine Triphosphate; Animals; Aorta; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; DNA; Enzyme Activation; Enzyme Inhibitors; Estrenes; Inositol 1,4,5-Trisphosphate; Kinetics; Lysophospholipids; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase C; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Swine; Thapsigargin; Virulence Factors, Bordetella | 1998 |
Staurosporine-induced Ca2+ mobilization in rat mandibular salivary acini.
Topics: Animals; Biological Transport; Calcium; Carbachol; Cholinergic Agonists; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Male; Rats; Rats, Sprague-Dawley; Staurosporine; Submandibular Gland; Thapsigargin | 1998 |
Ca2+-dependent inactivation of a store-operated Ca2+ current in human submandibular gland cells. Role of a staurosporine-sensitive protein kinase and the intracellular Ca2+ pump.
Topics: Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Line; Enzyme Inhibitors; Feedback; Humans; Hydroquinones; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Submandibular Gland; Thapsigargin | 1998 |
Biophysical signals underlying myogenic responses in rat interlobular artery.
Topics: Animals; Blood Pressure; Carbamates; Gadolinium; Hydronephrosis; Ion Channels; Kidney; Male; Phenylcarbamates; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Renal Artery; Staurosporine; Thapsigargin; Type C Phospholipases | 1998 |
Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells.
Topics: Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Epithelial Cells; GTP-Binding Proteins; Histamine; Humans; Inositol Phosphates; Lysophospholipids; Magnesium; Nasal Cavity; Palmitic Acid; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Staurosporine; Thapsigargin; Time Factors; Virulence Factors, Bordetella | 1998 |
Role of Ca2+-ATPase inhibitors in activation of cytosolic phospholipase A2 in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cell-Free System; Chelating Agents; Cytosol; DNA, Complementary; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Lipid Metabolism; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Binding; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; U937 Cells | 1999 |
Redox modulation of intracellular free calcium concentration in thyroid FRTL-5 cells: evidence for an enhanced extrusion of calcium.
Topics: Animals; Barium; Calcium; Calcium-Transporting ATPases; Cell Line; Enzyme Activation; Hydrogen-Ion Concentration; Imidazoles; Membrane Potentials; Mercaptoethanol; Oxidation-Reduction; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Binding; Protein Kinase C; Rats; Staurosporine; tert-Butylhydroperoxide; Tetradecanoylphorbol Acetate; Thapsigargin; Thimerosal; Thyroid Gland; Vanadates | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
Polycations induce calcium signaling in glomerular podocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Benzoquinones; Calcium Signaling; Cells, Cultured; DEAE-Dextran; Heparin; Kidney Glomerulus; Lactams, Macrocyclic; Marine Toxins; Mice; Muramidase; Oxazoles; Protamines; Quinones; Rifabutin; Staurosporine; Thapsigargin | 1999 |
A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+.
Topics: 17-alpha-Hydroxyprogesterone; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Drug Synergism; Fura-2; Gonadotropin-Releasing Hormone; Ionomycin; Leydig Cells; Luteinizing Hormone; Male; Melatonin; Pertussis Toxin; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.
Topics: Animals; Calcium; Carbachol; Cholinergic Agonists; Enzyme Activation; Enzyme Inhibitors; Fura-2; Isoenzymes; Lacrimal Apparatus; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Induction and secretion of the chemokines interleukin-8 and monocyte chemotactic protein-1 in human immature leukemia cell lines.
Topics: Calcimycin; Carcinogens; Chemokine CCL2; Chemokines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; HL-60 Cells; Humans; Interleukin-8; Ionophores; Leukemia; Protein Biosynthesis; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.
Topics: Animals; Anthracenes; Atropine; Calcium; Calcium Signaling; Cells, Cultured; Chelating Agents; Cloning, Molecular; Cytoplasm; Egtazic Acid; Enzyme Inhibitors; Ethylmaleimide; Gene Expression; GTP-Binding Proteins; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Oxotremorine; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Second Messenger Systems; Staurosporine; Superior Cervical Ganglion; Tetraethylammonium; Thapsigargin | 2000 |
Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Calcium; Cells, Cultured; Collagen; Felodipine; Fluorescent Dyes; Fura-2; Glutathione; Homocysteine; Homocystine; Kinetics; Muscle, Smooth, Vascular; Neomycin; NG-Nitroarginine Methyl Ester; Pravastatin; Rats; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cyclic AMP; Egtazic Acid; Estrenes; Imidazoles; Ionomycin; Manganese; Muscle, Smooth, Vascular; Phosphorylcholine; Pyrrolidinones; Sphingosine; Staurosporine; Swine; Thapsigargin; Thionucleosides; Thionucleotides; Virulence Factors, Bordetella | 2000 |
Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release.
Topics: Animals; Apoptosis; Atractyloside; bcl-2-Associated X Protein; Caspase 3; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; Gelsolin; Humans; Intracellular Membranes; Jurkat Cells; Kinetics; Male; Membrane Potentials; Mitochondria; Mitochondria, Liver; Phosphatidylinositols; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Protoporphyrins; Rats; Recombinant Proteins; Staurosporine; Thapsigargin | 2000 |
NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways.
Topics: Animals; Animals, Newborn; Apoptosis; Calcium; Calcium-Binding Proteins; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cell Survival; Enzyme Activation; Hippocalcin; Humans; In Situ Hybridization; Motor Neurons; Nerve Tissue Proteins; Neuronal Apoptosis-Inhibitory Protein; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Staurosporine; Thapsigargin; Transfection; Two-Hybrid System Techniques | 2000 |
Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis.
Topics: Animals; Apoptosis; Calcium; Calcium-Binding Proteins; Calnexin; Calreticulin; Cell Line; Cloning, Molecular; Cytochrome c Group; Dogs; Endoplasmic Reticulum; Etoposide; HeLa Cells; Humans; Membrane Proteins; Mice; Mitochondria; Molecular Chaperones; Rabbits; Ribonucleoproteins; Staurosporine; T-Lymphocytes; Thapsigargin; Ultraviolet Rays | 2000 |
Hydrogen peroxide attenuates store-operated calcium entry and enhances calcium extrusion in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Barium; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Line; Down-Regulation; Enzyme Activation; Hydrogen Peroxide; Isoenzymes; Manganese; Membrane Potentials; Mercaptoethanol; Naphthalenes; Oxidation-Reduction; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Rats; Sodium; Staurosporine; Thapsigargin; Thyroid Gland | 2000 |
Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.
Topics: Androstadienes; Apoptosis; Bacterial Proteins; Bacterial Toxins; bcl-X Protein; Biomarkers; Cell Differentiation; Cell Size; DNA Fragmentation; Gene Expression Regulation; Humans; Microtubule-Associated Proteins; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphopyruvate Hydratase; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; rhoA GTP-Binding Protein; Signal Transduction; Staurosporine; Synaptophysin; Tetradecanoylphorbol Acetate; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Wortmannin | 2001 |
Regulation of SERCA Ca2+ pump expression by cytoplasmic Ca2+ in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blotting, Northern; Calcimycin; Calcium; Calcium-Transporting ATPases; Carrier Proteins; Cells, Cultured; Cytoplasm; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Gene Expression; Heat-Shock Proteins; Homeostasis; Ionophores; Male; Molecular Chaperones; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Staurosporine; Thapsigargin | 2001 |
Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
Topics: Calcineurin; Calcineurin Inhibitors; Calcium Signaling; Capsid; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Herpesvirus 8, Human; Humans; Indoles; Ionomycin; Maleimides; Microscopy, Electron; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; Virus Activation | 2001 |
Signal transduction in eclosion hormone-induced secretion of ecdysis-triggering hormone.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Egtazic Acid; Insect Hormones; Manduca; Marine Toxins; Oxazoles; Signal Transduction; Staurosporine; Thapsigargin | 2001 |
Unreliability of the cytochrome c-enhanced green fluorescent fusion protein as a marker of cytochrome c release in cells that overexpress Bcl-2.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspases; Cytochrome c Group; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Genetic Markers; Green Fluorescent Proteins; Humans; Immunohistochemistry; Luminescent Proteins; Microscopy, Fluorescence; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Staurosporine; Subcellular Fractions; Thapsigargin; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Catalase; Cell Division; Cytochrome c Group; Cytosol; Dexamethasone; Drug Resistance; Etoposide; Glutathione Transferase; Hydrogen Peroxide; Mice; Paraquat; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Superoxide Dismutase; Thapsigargin; Thymus Gland; Tumor Cells, Cultured | 2001 |
Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells.
Topics: Apoptosis; Brain Ischemia; Calcium; Calcium-Transporting ATPases; Cytosol; Dantrolene; Egtazic Acid; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Hydroquinones; Indoles; Muscle Relaxants, Central; Neuroblastoma; Neurons; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sesquiterpenes; Staurosporine; Thapsigargin; Tumor Cells, Cultured | 2002 |
Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Calcium Signaling; Caspases; Chelating Agents; Chromatography, High Pressure Liquid; Cladribine; Cytochrome c Group; Deoxyadenine Nucleotides; Deoxycytidine Kinase; DNA Fragmentation; Drug Resistance, Neoplasm; Egtazic Acid; Enzyme Activation; Intracellular Membranes; Membrane Potentials; Mitochondria; Neoplasm Proteins; Neoplastic Stem Cells; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-bcl-2; Staurosporine; Thapsigargin | 2002 |
Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells.
Topics: Adenosine Triphosphate; Animals; Basophils; Caffeic Acids; Calcium; Electric Conductivity; Enzyme Inhibitors; Intracellular Membranes; Leukotrienes; Lipoxygenase Inhibitors; Masoprocol; Osmolar Concentration; Patch-Clamp Techniques; Permeability; Rats; Sodium; Staurosporine; Thapsigargin; Tumor Cells, Cultured | 2002 |
Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.
Topics: Antibodies; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinoma; Colonic Neoplasms; Epithelial Cells; fas Receptor; Humans; Membrane Glycoproteins; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Thapsigargin; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death.
Topics: Adenoviridae; Animals; Arsenates; Brefeldin A; Calcium; Cathepsin B; Cell Death; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Genetic Vectors; Gerbillinae; Glutamic Acid; Hippocampus; HSP70 Heat-Shock Proteins; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; In Situ Hybridization; Male; Neurons; Protein Synthesis Inhibitors; Proteins; Staurosporine; Thapsigargin | 2002 |
Activation of angiotensin II type I receptor promotes protein kinase C translocation and cell proliferation in human cultured breast epithelial cells.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Biological Transport; Breast; Calcium Signaling; Carbazoles; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Estrenes; Female; Humans; Indoles; Isoenzymes; Losartan; Protein Kinase C; Pyrrolidinones; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Staurosporine; Thapsigargin; Type C Phospholipases | 2002 |
Inhibition of prostaglandin E(2) production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action.
Topics: Animals; Arachidonic Acid; Araliaceae; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Lactones; Lignans; Macrophages, Peritoneal; Male; Membrane Proteins; Plant Roots; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 2002 |
IgG-mediated signal transduction in canine mastocytoma-derived cells.
Topics: Acridines; Animals; Binding Sites; Calcium; Calcium Signaling; Dogs; Histamine Release; Immunoglobulin E; Immunoglobulin G; Mastocytoma; Neoplasm Proteins; Phosphorylation; Signal Transduction; Staurosporine; Thapsigargin; Tumor Cells, Cultured; Tyrosine | 2002 |
Protection of mature oligodendrocytes by inhibitors of caspases and calpains.
Topics: Amino Acid Chloromethyl Ketones; Animals; Calcium; Calpain; Caspase Inhibitors; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Kainic Acid; Mice; Mice, Inbred BALB C; Oligodendroglia; Penicillamine; Staurosporine; Thapsigargin | 2003 |
Role of Ca2+ feedback on single cell inositol 1,4,5-trisphosphate oscillations mediated by G-protein-coupled receptors.
Topics: Animals; Calcium Signaling; CHO Cells; Cricetinae; Enzyme Inhibitors; Feedback, Physiological; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Norepinephrine; Protein Kinase C; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-1; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Staurosporine; Thapsigargin; Type C Phospholipases | 2003 |
IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.
Topics: Androstadienes; Anilides; Animals; Annexin A5; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Chromones; Culture Media, Serum-Free; Flavonoids; Flow Cytometry; Humans; Imidazoline Receptors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Morpholines; Oligopeptides; PC12 Cells; Proteins; Rats; Staurosporine; Thapsigargin; Transfection; Wortmannin | 2003 |
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Genetic Vectors; Glucose; Interleukin-3; Lactates; Membrane Potentials; Mice; Mitochondria; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Signal Transduction; Sirolimus; Staurosporine; Thapsigargin; Time Factors; Transcription, Genetic; Transgenes | 2003 |
Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Apoptosis; Apoptosis Regulatory Proteins; Arabidopsis Proteins; Blotting, Western; Brain Chemistry; Carrier Proteins; Caspase 8; Caspases; Cell Line; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; COS Cells; Culture Media, Serum-Free; DNA-Binding Proteins; Down-Regulation; Endoplasmic Reticulum; fas Receptor; Fatty Acid Desaturases; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Immunohistochemistry; Luminescent Proteins; Male; Membrane Proteins; Microscopy, Fluorescence; Molecular Sequence Data; Nervous System; Neurons; Oligodeoxyribonucleotides, Antisense; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Sequence Homology, Amino Acid; Signal Transduction; Staurosporine; Thapsigargin; Transfection; Tumor Necrosis Factor-alpha | 2003 |
Exocytosis of a complement component C3-like protein by tunicate hemocytes.
Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcimycin; Carrageenan; Cell Survival; Cholera Toxin; Colchicine; Colforsin; Complement C3; Cytochalasin D; Cytoplasmic Vesicles; Enzyme-Linked Immunosorbent Assay; Exocytosis; Hemocytes; Immunohistochemistry; Kinetics; Lipopolysaccharides; Mannans; Microscopy, Electron; Phenanthridines; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Urochordata | 2004 |
Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells.
Topics: Animals; Arsenicals; Cell Line; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; Genistein; Glycine; Humans; N-Methylaspartate; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor Cross-Talk; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Resorcinols; Staurosporine; Thapsigargin; Transfection; Tyrosine; Vanadates | 2004 |
Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart.
Topics: Adenosine Triphosphatases; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Calcium Channels, L-Type; Calcium Signaling; Cardiomyopathies; Cells, Cultured; Cricetinae; Enalaprilat; Enzyme Activation; Extracellular Fluid; Intracellular Fluid; Losartan; Male; Mesocricetus; Myocytes, Cardiac; Protein Kinase C; Sarcoplasmic Reticulum; Staurosporine; Thapsigargin | 2004 |
Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.
Topics: Boron Compounds; Calcium; Calcium Channel Blockers; Cytosol; Dantrolene; Dose-Response Relationship, Drug; Estrenes; Fatty Alcohols; Glycols; HeLa Cells; Humans; Imidazoles; Indoles; Intracellular Space; Maleimides; Nickel; Nifedipine; Plasmids; Propranolol; Protein Kinase Inhibitors; Pyrrolidinones; Receptors, Leukotriene B4; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection | 2004 |
Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney.
Topics: Angiotensin II; Animals; Arterioles; Calcium; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydronephrosis; Hypertension; Kidney; Male; Mibefradil; Microcirculation; Nifedipine; Perfusion; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Staurosporine; Thapsigargin; Vasodilator Agents | 2005 |
Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes.
Topics: Animals; Animals, Newborn; Annexin A5; Antimycin A; Apoptosis; Astrocytes; Caffeine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Central Nervous System Depressants; Central Nervous System Stimulants; Chlorides; Digitonin; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ethanol; Flow Cytometry; Fura-2; In Situ Nick-End Labeling; Indicators and Reagents; Ionophores; Manganese Compounds; Propidium; Rats; Staurosporine; Thapsigargin; Time Factors | 2006 |
Inhibition of the renal betaine transporter by calcium ions.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Line; Cell Membrane; Dogs; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; Hypertonic Solutions; Ionomycin; Kidney; Phorbol Esters; Protein Kinase C; Signal Transduction; Staurosporine; Thapsigargin | 2006 |
Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; bcl-X Protein; Blotting, Northern; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cytochromes c; Dexamethasone; Enzyme Activation; Etoposide; Gene Expression; Mifepristone; Receptors, Glucocorticoid; RNA, Messenger; RNA, Small Interfering; Staurosporine; Thapsigargin | 2006 |
Cyclic GMP-dependent pathways protect differentiated oligodendrocytes from multiple types of injury.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bongkrekic Acid; Cell Death; Cell Differentiation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclosporine; Kainic Acid; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nitric Oxide; Nitroso Compounds; Oligodendroglia; Rats; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Staurosporine; Thapsigargin | 2007 |
Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts.
Topics: Apoptosis; Cells, Cultured; Cellular Senescence; Cyclic AMP Response Element-Binding Protein; Diploidy; Down-Regulation; Fibroblasts; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Phosphoprotein Phosphatases; Phosphoproteins; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Thapsigargin | 2007 |
Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.
Topics: Animals; Apoptosis; Calcium; Calcium Signaling; Caspase 3; Cell Line; Enzyme Inhibitors; Female; Humans; Inositol 1,4,5-Trisphosphate Receptors; Meiosis; Mice; Mice, Knockout; Oocytes; Staurosporine; Thapsigargin | 2008 |
Degradation of caspase-activated DNase by the ubiquitin-proteasome system.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Chlorides; Deoxyribonucleases; DNA Fragmentation; Fibroblasts; Gene Expression; HeLa Cells; Humans; Leupeptins; Manganese Compounds; Mice; NIH 3T3 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rotenone; Staurosporine; Thapsigargin; Transfection; Ubiquitin; Ubiquitination | 2008 |
Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
Topics: Alkaloids; Animals; Apoptosis; Aspartic Acid; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Drug Interactions; Enzyme Inhibitors; Hydrogen Peroxide; Ionophores; Motor Neurons; Neuroprotective Agents; Organ Culture Techniques; Oxidants; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spinal Cord; Staurosporine; Thapsigargin | 2008 |
On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis.
Topics: Apoptosis; Cellular Senescence; Child, Preschool; Diploidy; Down-Regulation; Fibroblasts; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Male; Organ Specificity; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Stress, Physiological; Thapsigargin; Vault Ribonucleoprotein Particles | 2008 |
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; BH3 Interacting Domain Death Agonist Protein; Cells, Cultured; Etoposide; Fibroblasts; Green Fluorescent Proteins; Immunoblotting; Immunoprecipitation; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Fluorescence; Mitochondria; Models, Biological; Mutation; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins; Staurosporine; Thapsigargin; Tumor Suppressor Proteins; Tunicamycin | 2009 |
Effects of some modulators on purine nucleoside phosphorylase activity in myocardial tissue.
Topics: Adenosine; Animals; Calcium; Edetic Acid; Guanosine; Hydrogen-Ion Concentration; Myocardium; Purine-Nucleoside Phosphorylase; Staurosporine; Substrate Specificity; Swine; Thapsigargin; Thionucleosides | 2010 |
Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells.
Topics: Animals; Apoptosis; Caspase 12; Cells, Cultured; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Influenza A Virus, H1N1 Subtype; JNK Mitogen-Activated Protein Kinases; Lung; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Respiratory Mucosa; Staurosporine; Thapsigargin; Transcription Factors; Transforming Growth Factor beta; Viral Load | 2012 |
Pancreatic β-cell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels.
Topics: Acetylation; Adult; Apoptosis; Cell Line; Cell Nucleus; Cell Survival; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Histone Acetyltransferases; Histone Deacetylases; Humans; Incretins; Insulin-Secreting Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Ribosomal Protein S6 Kinases, 90-kDa; Shab Potassium Channels; Staurosporine; Thapsigargin | 2012 |
Neurotoxic injury pathways in differentiated mouse motor neuron-neuroblastoma hybrid (NSC-34D) cells in vitro--limited effect of riluzole on thapsigargin, but not staurosporine, hydrogen peroxide and homocysteine neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Calcium; Caspase 3; Caspase 7; Cell Line; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Homocysteine; Hybrid Cells; Hydrogen Peroxide; Mice; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Neurotoxins; Riluzole; Staurosporine; Thapsigargin | 2012 |
Protease activation and the signal transduction pathway regulating motility in sperm from the water strider Aquarius remigis.
Topics: Animals; Calcium; Egtazic Acid; Heteroptera; Male; MAP Kinase Signaling System; Marine Toxins; Oxazoles; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptor, PAR-2; Signal Transduction; Sperm Motility; Spermatozoa; Staurosporine; Thapsigargin; Trypsin | 2012 |
Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Membrane Proteins; Mice; Mitochondrial Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms; NIH 3T3 Cells; Oncogene Protein p21(ras); Proteolysis; raf Kinases; src-Family Kinases; Staurosporine; Thapsigargin | 2012 |
An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Carrier Proteins; Caspases; Cell Line, Tumor; Chromatin; Colchicine; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Microfilament Proteins; Necrosis; Neurons; Nocodazole; Peptidomimetics; Quinolines; Rotenone; Signal Transduction; Staurosporine; Thapsigargin | 2015 |
DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress.
Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line; Cytochromes c; Dynamins; Fibroblasts; Gene Expression Regulation; Hydrogen Peroxide; Mice; Mice, Knockout; Mitochondrial Dynamics; Oxidative Stress; Signal Transduction; Staurosporine; Thapsigargin | 2016 |
The Mechanism of Action of Ghrelin and Motilin in the Pacemaker Potentials of Interstitial Cells of Cajal from the Murine Small Intestine.
Topics: Acetophenones; Amides; Animals; Benzopyrans; Boron Compounds; Calcium; Carbazoles; Gastrointestinal Motility; Ghrelin; Inositol 1,4,5-Trisphosphate Receptors; Interstitial Cells of Cajal; Intestine, Small; Macrocyclic Compounds; Membrane Potentials; Mice; Mice, Inbred ICR; Motilin; Oligopeptides; Oxazoles; Protein Kinase C; Pyridines; Receptors, Ghrelin; rho-Associated Kinases; Signal Transduction; Staurosporine; Thapsigargin | 2019 |