staurosporine has been researched along with tetradecanoylphorbol acetate in 1145 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (3.93) | 18.7374 |
| 1990's | 951 (83.06) | 18.2507 |
| 2000's | 138 (12.05) | 29.6817 |
| 2010's | 11 (0.96) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crook, RB; Yabu, JM | 1 |
| Alkhalaf, B; Ballejo, G; Gong, Y; Molnar, P; Murphy, LC; Murphy, LJ | 1 |
| Bevan, JA; Henrion, D; Laher, I; Laporte, R | 1 |
| Becker, C; Bouron, A; Neuhaus, R; Reber, BF; Reuter, H | 1 |
| Rodríguez Del Castillo, A; Trifaró, JM; Vitale, ML | 1 |
| Gandhi, VC; Jones, DJ | 1 |
| García-Sáinz, JA; López-Gómez, FJ; Robles-Flores, M | 1 |
| Kamikawaji, N; Kimura, A; Nishimura, Y; Odum, N; Okamoto, Y; Sasazuki, T; Yoshizumi, H | 1 |
| Aubourg, A; Ollivier-Bousquet, M | 1 |
| Holmes, R; Kelly, E; Perez, HD | 1 |
| de Boland, AR; Massheimer, V | 1 |
| Fukuda, M; Maeda, K; Tagami, H; Tomita, Y | 1 |
| Conquer, JA; Cruz, TF; Kandel, RA | 1 |
| Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Cragoe, EJ; Haddad, P; Haman, A; Hoang, T; Rajotte, D | 1 |
| Corvol, P; Eckardt, KU; Fabbro, D; Kurtz, A; Pugh, C; Ratcliffe, P | 1 |
| Birkenhäger, JC; Bos, MP; Buurman, CJ; Pols, HA; Staal, A; van den Bemd, GJ; van Leeuwen, JP | 1 |
| Croatto, M; Hamilton, JA; Phillips, WA; Veis, N | 1 |
| Müller, S; Nigam, S; Walzog, B | 1 |
| Biel, M; Dascal, N; Flockerzi, V; Gershon, E; Hofmann, F; Hullin, R; Lotan, I; Singer-Lahat, D | 1 |
| Ashcroft, SJ; Goodison, S; Kenna, S | 1 |
| Berthoud, VM; Hertzberg, EL; Ledbetter, ML; Sáez, JC | 1 |
| Günther, T; Höllriegl, V; Vormann, J | 1 |
| Ganapathy, V; Leibach, FH; Mahesh, VB; Ramamoorthy, S | 1 |
| Favus, MJ; Ro, HK; Tembe, V | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Franks, DJ; Weaver, VM; Welsh, JE | 1 |
| Hayashi, K | 1 |
| Kiss, Z | 2 |
| Dieter, P; Duyster, J; Fitzke, E; Schulze-Specking, A | 1 |
| Fujimoto, M; Shigeri, Y | 1 |
| Kawase, T; Orikasa, M; Suzuki, A | 2 |
| Bégeot, M; Berthelon, MC; Jaillard, C; Langlois, D; Saez, JM | 1 |
| Huggler, E; Krause, KH; Lew, DP; Monod, A; van Delden, C | 1 |
| Scott, RE; Wang, H | 1 |
| Koyama, N; Morisaki, N; Saito, Y; Yoshida, S | 1 |
| Bidlack, JM; Gucker, S | 1 |
| Humphries, RK; Kay, RJ; Krystal, G; Mui, AL | 1 |
| Graham, CS; Tashjian, AH | 1 |
| Aharonovits, O; Granot, Y; Livne, AA; Zik, M | 1 |
| Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Izumi, N; Liu, J; Liu, JH; Marumo, F; Sakai, Y; Sato, C; Takano, T; Tang, L; Yauchi, T | 1 |
| Breyer, MD; Carter, CE; Jacobson, HR; Noland, TD | 1 |
| Balla, T; Catt, KJ; Clark, AJ; Jones, MR | 1 |
| Adlersberg, M; Gershon, MD; Hsiung, SC; Liu, KP; Nunez, EA; Tamir, H; Yu, PY | 1 |
| Chadee, K; Keller, K; Olivier, M | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J | 1 |
| Desai, SN; Letts, GL; Myers, CL; Schembri-King, J; Wallace, RW | 1 |
| Akerman, K; Heikkilä, J; Jalava, A; Lintunen, M; Påhlman, S | 1 |
| Chen, T; Mathews, S; Meier, RW; Niklaus, G; Tobler, A | 1 |
| Chaudhary, PM; Roninson, IB | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A | 1 |
| Andrews, PE; Montgomery, BT; Tindall, DJ; Young, CY | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Matsui, S; Matsumoto, Y; Tanimura, A; Tojyo, Y | 2 |
| Luna, EJ; Shariff, A | 1 |
| Bradbury, NA; Bridges, RJ | 1 |
| González, AV; Maghazachi, AA; Phillips-Quagliata, JM; Rao, TD | 1 |
| Chambers, TC; Kuo, JF; Zheng, B | 1 |
| Gilfillan, AM; Lin, P | 1 |
| Lee, CM; Tung, WL; Young, JD | 1 |
| Jamieson, JD; O'Sullivan, AJ | 1 |
| Durum, SK; Kung, HF; Ramsburg, EA; Smith, MR | 1 |
| Chakravarty, N | 1 |
| Fernandez-Gallardo, S; Guntaka, RV; Kandala, JC; Lim, RW; Shukla, SD; Tripathi, YB | 1 |
| Goberna, R; Lucas, M; Sanchez, V; Sanz, A | 1 |
| Messina, JL | 1 |
| Chang, JP; Jobin, RM | 1 |
| Huang, CF; Schmidt, J; Tong, J | 1 |
| Gschwendt, M; Kittstein, W; Lindner, D; Marks, F | 1 |
| Andrejauskas-Buchdunger, E; Regenass, U | 1 |
| Taylor, DJ | 1 |
| Bennett, MV; Durand, GM; Gregor, P; Uhl, GR; Zheng, X; Zukin, RS | 1 |
| Joseph, S; MacDermot, J | 1 |
| Gutman, Y; Zilberman, Y | 1 |
| Chaudhari, S; Conlon, J; Conlon, P; Gervais, M | 1 |
| Breitbart, H; Homonnai, ZT; Kalina, M; Lax, J; Naor, Z; Paz, GF; Rotem, R | 1 |
| Dahinden, CA; Krieger, M; von Tscharner, V | 1 |
| Ishihara, M; Jiang, H; Kato, R; Nishikawa, K; Wang, JC; Yamamoto, S | 1 |
| Kobayashi, T | 1 |
| Pradines-Figueres, A; Raetz, CR | 1 |
| Abraham, RT; Leibson, PJ; Schoon, RA; Ting, AT | 1 |
| Akimaru, K; Edashige, K; Kasai, M; Sato, EF; Utsumi, K | 1 |
| Anderson, GM; Horne, WC | 1 |
| Bruder, JM; Krebs, WD; Nett, TM; Wierman, ME | 1 |
| Lund-Johansen, F; Olweus, J | 1 |
| Lin, YW; Petrino, TR; Wallace, RA | 1 |
| Meltzer, M; Mufson, RA; Myers, C; Turpin, JA | 1 |
| Alkhalaf, B; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Deli, E; Kiss, Z | 1 |
| Kozawa, O; Miwa, M; Tokuda, H | 2 |
| Kato, R; Nishikawa, K; Otsuka, C; Yamamoto, S | 1 |
| Hazeki, O; Kume, S; Ui, M; Yatomi, Y | 1 |
| Meldrum, BS; Smith, SE | 1 |
| MacLeod, EA; Olson, DM; Zakar, T | 1 |
| Allo, SN; Carl, LL; Morgan, HE | 1 |
| Burroughs, S; Feinstein, MB; Huang, CK; Lau, LF; Pumiglia, KM | 1 |
| Carew, MA; Paleolog, EM; Pearson, JD | 1 |
| Hargrove, ME; Ting, CC | 1 |
| Crichton, CA; Currie, S; Hallam, C; Jackson, CG; Smith, GL; Wakelam, MJ | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI; Wang, E; Yamazaki, M | 1 |
| Dominguez, J; Garcia, JG; Natarajan, V; Patterson, CE; Stasek, J | 1 |
| Schatz-Munding, M; Ullrich, V | 1 |
| Ichikawa, A; Negishi, M; Ohnishi, M; Takahashi, S | 1 |
| Jiang, H; Kato, R; Yamamoto, S | 1 |
| Buday, L; Faragó, A; Hajnóczky, G; Spät, A; Várnai, P | 1 |
| Burrow, GN; Eggo, MC; Lippes, H | 1 |
| Cataldo, A; Hauser, G; Leli, U; Nixon, RA; Shea, TB | 1 |
| Lane, HA; Susa, M; Thomas, G; Vulević, D | 1 |
| Bandyopadhyay, SK; Sen, GC | 1 |
| Bouaboula, M; Casellas, P; d'Angeac, AD; Dornand, J; Favero, J; Shire, D | 1 |
| Bradshaw, TD; Gescher, A; Pettit, GR | 1 |
| Beckman, BS | 1 |
| Chambaz, E; Mauduit, P; Pelosin, JM; Rossignol, B; Sergheraert, C; Zoukhri, D | 1 |
| Berkow, RL | 1 |
| Arata, Y; Kume, S; Tada, S; Ui, M; Yatomi, Y | 1 |
| Kelleher, D; Long, A | 1 |
| Murgo, AJ; Sistare, FD | 1 |
| Duronio, V; Finlay, BB; Rosenshine, I | 1 |
| Cockcroft, S; Geny, B | 1 |
| Carrier, F; Nebert, DW; Puga, A | 1 |
| Gotlieb, AI; Yu, JC | 1 |
| Azula, FJ; Font, J; Macarulla, JM; Marino, A; Nieva, N; Trueba, M | 1 |
| Garland, JM; Harel-Bellan, A; Robin, P | 1 |
| Knopf, JL; Lin, AY; Lin, LL | 1 |
| Blok, LJ; de Jong, FH; Grootegoed, JA; Klaij, IA; Timmerman, MA | 1 |
| Crews, FT; Guzman, NJ | 1 |
| Lazarovici, P; Lester, D; Matsuda, Y; Rahamim, E; Rasouly, D | 1 |
| Chase, HS; Lindeman, RP | 1 |
| Freissmuth, M; Palmer, S; Pyne, NJ | 1 |
| Gschwendt, M; Kittstein, W; Leibersperger, H; Marks, F | 1 |
| Chappell, JB; Henderson, LM | 1 |
| Catt, KJ; Iida, T; Krsmanović, LZ; Merelli, F; Stojilković, SS; Torsello, A | 1 |
| Evans, CH; Georgescu, HI; Hulkower, KI | 1 |
| Asano, K; Iizuka, H; Ito, F; Takahashi, H; Tamura, T; Tsutsui, M | 1 |
| Brakebusch, C; Holtmann, H; Klocke, R; König, M; Resch, K; Wallach, D; Winzen, R | 1 |
| Livne, AA; Pouyssegur, J; Sardet, C | 1 |
| Ishihara, H; Shikita, M; Takeuchi, K; Tsuneoka, K | 1 |
| Constantinescu, SN; Popescu, LM | 1 |
| Axelrod, J; Felder, CC; Williams, HL | 1 |
| Davis, PD; Nixon, JS; Sedgwick, AD; Wadsworth, J; Westmacott, D; Wilkinson, SE | 1 |
| Cardinale, I; Sehgal, PB; Tamm, I | 1 |
| Becker, EL; Huang, CK; Molski, TF; Sha'afi, RI; Stevens, T; Yamazaki, M | 1 |
| Aharonovitz, O; Fridman, H; Livne, AA; Markus, S; Tsukitani, Y | 1 |
| Alm, GV; Eloranta, ML; Gobl, AE; Sandberg, K | 1 |
| Feldman, D; Krishnan, AV | 1 |
| Fandrey, J; Huwiler, A; Jelkmann, W; Pfeilschifter, J | 1 |
| Okamoto, K; Sakai, Y; Sakuta, H; Sekiguchi, M | 2 |
| Ermel, B; Häring, HU; Kellerer, M; Mühlhöfer, A; Müller, HK; Obermaier-Kusser, B; Vogt, B | 1 |
| Anderson, CM; Olefsky, JM | 1 |
| Kasuga, M; Konda, Y; Matozaki, T; Matsuda, K; Nagao, M; Nakano, O; Nishisaki, H; Sakamoto, C; Suzuki, T; Wada, K | 1 |
| Duszynski, J; Hreniuk, S; LaNoue, KF; Waybill, MM; Zhang, Y | 1 |
| Altschuler, E; Chan, D; Hinds, M; Mayes, J; Zwelling, LA | 1 |
| Kato, Y; Ogawa, K; Okuda, T; Okuma, M; Sawada, H; Tashima, M; Yumoto, Y | 1 |
| Elmore, M; Kellie, S; Murphy, CT; Westwick, J | 1 |
| Aharonovitz, O; Livne, AA; Paran, E | 1 |
| Balazovich, K; McNish, RW; Peters-Golden, M; Sporn, PH | 1 |
| Schultz, RM | 1 |
| Koch, B; Lutz-Bucher, B | 1 |
| Fuller, SJ; Gaitanaki, CJ; Hatchett, RJ; Sugden, PH | 1 |
| Buyon, JP; Merrill, JT; Reed, W; Ross, GD; Roubey, RA; Walton, F; Winchester, RJ | 1 |
| Dlugosz, AA; Yuspa, SH | 1 |
| Altschuld, RA; Hohl, CM; Hu, B | 1 |
| De Lisle, RC; Kitagawa, M; Williams, JA | 1 |
| Gilfillan, AM; Welton, AF; Wiggan, GA | 1 |
| MacGlashan, DW; Warner, JA | 1 |
| de Pont, JJ; Ederveen, AG; Van Emst-De Vries, SE; Willems, PH | 1 |
| Clancy, JP; McCann, JD; Welsh, MJ | 1 |
| Dobner, PR; Ruzicka, LA; Tischler, AS | 1 |
| Arita, Y; Kimura, T; Nawata, H; Ogami, Y | 1 |
| Budel, LM; Delwel, R; Elbaz, O; Hoogerbrugge, H; Löwenberg, B; Mahmoud, LA; Touw, IP | 1 |
| Ewenstein, BM; Johnson, DR; Pober, JS; Ritchie, AJ | 1 |
| Bahrami, LH; Lenhard, LW; Pandol, SJ; Perkins, PS | 1 |
| Knol, EF; Koenderman, L; Mul, FP; Roos, D; Verhoeven, AJ | 1 |
| Furuya, W; Grinstein, S | 1 |
| Hibbs, ML; Larson, RS; Springer, TA | 1 |
| Kikuchi, T; Tamm, I | 1 |
| Benrezzak, O; Morisset, J; Paquette, B | 1 |
| Johnson, AL; Tilly, JL | 1 |
| Cinotti, GA; Menè, P; Pugliese, F | 1 |
| Cohan, VL; Gittlen, SW; Kagey-Sobotka, A; Lichtenstein, LM; MacGlashan, DW; Massey, WA; Warner, JA | 1 |
| Jansen, PL; Ottenhoff, R; Oude Elferink, RP; Roelofsen, H | 1 |
| Anderson, RJ; Breckon, R; Colston, D | 1 |
| Grinstein, S; Nanda, A | 1 |
| Norman-O'Guin, K; Shafit-Zagardo, B; Sharma, N | 1 |
| Kojima, I; Shibata, H | 1 |
| Alberola-Ila, J; Lozano, F; Places, L; Vives, J | 1 |
| Gschwendt, M; Lindner, D; Marks, F | 1 |
| Aigner, L; Brockhaus, M; Hohmann, HP; Remy, R; van Loon, AP | 1 |
| Davis, BB; Jacob, AK; Thomas, DJ; Zenser, TV | 1 |
| Barrett, KE; Dharmsathaphorn, K; Dinh, S; Kachintorn, U; Vajanaphanich, M; Vongkovit, P | 1 |
| Breitbart, H; Lax, J; Naor, Z; Rotem, R | 1 |
| Berezesky, IK; Fargnoli, J; Holbrook, NJ; Maki, A; Trump, BF | 1 |
| Roy, S; Vehar, GA; Zioncheck, TF | 1 |
| Breton, M; Colard, O | 1 |
| Gross, JL; Mochan, E; Newton, RC; Rommi, W; Uhl, J | 1 |
| Bernstein, SH; Kharbanda, SM; Kufe, DW; Sherman, ML; Stone, RM | 1 |
| Kessler, DS; Levy, DE | 1 |
| Barchowsky, A; Buckley, BJ; Dolor, RJ; Whorton, AR | 1 |
| Antel, JP; Couldwell, WT; Uhm, JH; Yong, VW | 1 |
| Gustafsson, JA; Legraverend, C; Mode, A; Tollet, P | 1 |
| Decker, K; Schulze-Specking, A; Weinhold, L | 1 |
| Konno, S; Wu, JM | 1 |
| Darbon, JM; Issandou, M | 2 |
| Boonen, HC; De Mey, JG | 1 |
| Barreau, P; Basset, M; Cost, H; Geny, B; Le Peuch, C | 1 |
| Goppelt-Strübe, M; Gunji, H; Hartmann, A; Hass, R; Hidaka, H; Kharbanda, S; Kufe, D; Meyer, G; Pfannkuche, HJ; Resch, K | 1 |
| Hayashi, M; Imai, Y; Oh-ishi, S | 1 |
| Arkin, H; Holland, JF; Ohnuma, T; Schwartz, GK | 1 |
| Caron, L; Grose, JH; Landry, J; Lebel, M | 1 |
| Apgar, JR | 2 |
| Auphan, N; Barad, M; Bizozzero, JP; Boyer, C; Luton, F; Malburet, JM; Reggio, H; Schmitt-Verhulst, AM | 1 |
| Arduino, C; Avanzi, GC; Brizzi, MF; Bussolino, F; Pegoraro, L | 1 |
| Mäntymaa, P; Pitkänen, M; Ruskoaho, H | 1 |
| Harrison, D; Lanier, LL; Phillips, JH | 1 |
| Marty, A; Tan, YP | 1 |
| Chang, CW; Hornsby, PJ; Naseeruddin, SA | 1 |
| Endou, M; Hattori, Y; Kanno, M; Tohse, N | 1 |
| Clark, RA; Leidal, KG; McCormick, S; Nauseef, WM; Volpp, BD | 1 |
| Frelin, C; Ladoux, A; Vigne, P | 1 |
| Edwards, SW; Robinson, J; Watson, F | 1 |
| Isosaki, M; Kurogochi, Y; Nakashima, T | 1 |
| Francis, J; Pon, DJ; Qu, Y; Sen, AK; Torchia, J | 1 |
| Johnson, JD; McIlroy, BK; Walters, JD | 1 |
| Crow, AR; Delovitch, TL; Lazarus, AH; Mills, GB | 1 |
| Akinaga, S; Gomi, K; Morimoto, M; Okabe, M; Tamaoki, T | 1 |
| Bowman, EP; Lambeth, JD; Olson, SC | 1 |
| Becker, AB; Gerrard, JM; Robertson, C; Saxena, SP | 1 |
| Adunyah, SE; Kraft, AS; Unlap, TM; Wagner, F | 1 |
| Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J | 1 |
| Chang, ZL; Novotney, M; Suzuki, T; Uchiyama, H | 1 |
| Ciment, G; Machida, CM; Scott, JD | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Lobo, MV; Marusic, ET | 1 |
| Ahrén, B; Karlsson, S | 1 |
| Tai, HH; Tian, ZG; Xun, CQ | 1 |
| Dieter, P; Fitzke, E | 1 |
| Miyamoto, S; Wu, JM | 1 |
| Chowdhury, IH; Hamamoto, Y; Kobayashi, S; Koyanagi, Y; Yamamoto, N; Yoshida, T; Yoshiyama, H | 1 |
| Faucon Biguet, N; Mallet, J; Vyas, S | 1 |
| Buyon, JP; Merrill, JT; Slade, SG; Weissmann, G; Winchester, R | 1 |
| Chang, K; Easom, RA; Sherman, WR; Turk, J; Williamson, JR; Wolf, BA | 1 |
| Haystead, TA; Krebs, EG; Licciardi, KA; Meier, KE | 1 |
| Bishop, WR; Pachter, JA; Pai, JK; Weinstein, IB | 1 |
| Malviya, AN; Nordmann, JJ; Stuenkel, EL | 1 |
| Kanaho, Y; Miura, K; Nozawa, Y; Yamada, K | 1 |
| Hendey, B; Mamrack, MD | 1 |
| Handschumacher, RE; Lee, CW; Sartorelli, AC; Sokoloski, JA | 1 |
| Braquet, P; Ferber, E; Fischer, G; Harell, T; Her, E; Naor, Z; Reiss, N; Zor, U | 1 |
| Harmody, D; Longley, RE | 1 |
| Sandmann, J; Wurtman, RJ | 1 |
| Campenot, RB; Draker, DD; Walji, AH | 1 |
| Keller, H; Niggli, V | 1 |
| Martin, DB; Pek, SB; Thomas, TP | 1 |
| Ide, T; Tsuji, K; Ueno, A | 1 |
| de Widt, J; Hilkmann, H; van Blitterswijk, WJ; van der Bend, RL | 1 |
| Baggiolini, M; Dahinden, CA; Deranleau, DA; Kernen, P; Spry, CJ; Tai, PC; von Tscharner, V; Wymann, MP | 1 |
| Williams, JA; Yule, DI | 1 |
| Della Bianca, V; Grzeskowiak, M; Lissandrini, D; Rossi, F | 1 |
| Hoffman, R; Newlands, ES | 1 |
| Kulyk, WM | 1 |
| Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C | 1 |
| Bohan, CA; Brady, JN; Gitlin, SD; Lindholm, PF; Marriott, SJ | 1 |
| Dan-Cohen, H; Naor, Z | 1 |
| Iaizzo, PA; Olsen, RA; Powis, G; Seewald, MJ; Sehgal, I | 1 |
| Capponi, AM; Chardonnens, D; Lang, U; Rossier, MF; Vallotton, MB | 1 |
| Gimbrone, MA; Hrbolich, JK; Schafer, AI; Zavoico, GB | 1 |
| Akiba, S; Fujii, T; Sato, T | 2 |
| Olianas, MC; Onali, P | 1 |
| Evanson, JM; Taylor, DJ; Woolley, DE | 1 |
| Fukuda, T; Kishi, K; Maeyama, K; Mamune-Sato, R; Miura, Y; Takishima, T; Tanno, Y; Watanabe, T | 1 |
| Béréziat, G; Cherqui, G; Etienne, J; Kadiri, C; Masliah, J; Rybkine, T | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Cooper, DR; Farese, RV; Nair, G; Pollet, RJ; Standaert, M; Vila, MC; Watson, JE | 1 |
| Fujiki, H; Hirasawa, N; Ohashi, M; Ohuchi, K; Ozeki, T; Tamura, T; Tsurufuji, S; Watanabe, M | 1 |
| Marshall, TM; Peters-Golden, M; Sporn, PH | 1 |
| Bhalla, RC; Chiang, JJ; Loeber, CP; Potts, JD; Runyan, RB; Sharma, RV | 1 |
| Chatila, T; Geha, R; Remold-O'Donnell, E; Rosen, F; Sancho, J; Terhorst, C; Vercelli, D; Wong, RC | 1 |
| Barendsen, N; Chen, B; Mueller, M | 1 |
| Benveniste, J; Bessou, G; Bossant, MJ; Joly, F; Ninio, E; Vigrain, I | 1 |
| Aguet, M; Ballotti, R; Mao, C; Merlin, G; Metzler, M | 1 |
| Dufau, ML; Fabbri, A; Tinajero, JC; Ulisse, S | 1 |
| Aten, RF; Behrman, HR; Musicki, B | 1 |
| Kato, Y; Ogawa, K; Okuda, T; Sawada, H; Tashima, M; Ueda, T; Yumoto, Y | 1 |
| Goodman, HM; Gorin, E; Honeyman, TW; Tai, LR | 1 |
| Azzi, A; Boscoboinik, DO; Hensey, CE | 1 |
| de Boland, AR; Norman, A | 1 |
| Davidson, JS; Macrae, MB; Millar, RP; van der Merwe, PA; Wakefield, IK | 1 |
| Abboud, HE; Jaffer, FE; Knauss, TC | 1 |
| Ito, N; Kawata, S; Shirai, Y; Takaishi, K; Tamura, S; Tarui, S | 1 |
| Patke, CL; Shearer, WT | 1 |
| Doppler, W; Grunicke, H; Hochleitner, B; Loferer, H; Maly, K; Oberhuber, H; Uberall, F | 1 |
| Dale, MM; Muid, RE; Twomey, B | 1 |
| Bonin, PD; Chiou, WJ; McGee, JE; Singh, JP | 1 |
| Badwey, JA; Heyworth, PG; Robinson, JM | 1 |
| Holz, RW; Terbush, DR | 1 |
| Keller, HU | 1 |
| Parker, PJ; Schaap, D | 1 |
| Brunsing, D; Hensel, G; Krönke, M; Meichle, A; Schütze, S | 1 |
| Hunziker, W; Koch, T; Mellman, I; Whitney, JA | 1 |
| Adu, J; Burgoyne, RD; Cambray-Deakin, MA | 1 |
| Duronio, V; Jacobs, S | 1 |
| Cooper, DR; Farese, RV; Ishizuka, T | 1 |
| Colca, JR; Easom, RA; Hughes, JH; Landt, M; McDaniel, M; Turk, J | 1 |
| Hamamoto, Y; Kobayashi, N; Yamamoto, N | 1 |
| Homonnai, ZT; Kalina, M; Naor, Z; Paz, GF; Rotem, R | 2 |
| Buckley, DJ; Cooper, DR; Farese, RV; Hoffman, JM; Ishizuka, T; Pollet, RJ; Standaert, ML | 1 |
| Levine, L | 1 |
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| Aten, J; Roos, A; Schilder-Tol, EJ; Weening, JJ | 1 |
| Hwang, BD; Lee, JI; Lim, K; Park, JI; Son, MY; Yoon, WH; Yun, KA | 1 |
| Ciereszko, RE; Guan, Z; Ottobre, AC; Ottobre, JS; Petroff, BK; Stokes, BT | 1 |
| Verspohl, EJ; Wienecke, A | 1 |
| Dyer, D; McCloud, E; Moyer, MP; Ortiz, A; Rubin, S; Said, HM | 1 |
| Begemann, M; Bruce, JN; Choi, YA; Christiansen, KM; Duigou, G; Fabbro, D; Ghosh, S; Heitjan, DF; Kashimawo, SA; Kim, S; Lampen, NM; Mueller, M; Schieren, I; Schiff, PB; Weinstein, IB | 1 |
| Chiang, HS; Huang, TF; Lin, SW; Yang, RS | 1 |
| Fujimoto, M; Nagasaka, Y; Nakamura, K; Tanaka, T | 1 |
| Hagiwara, Y; Hanada, M; Kambe, T; Kubo, T; Saito, E | 1 |
| Bradford, MD; Soltoff, SP | 1 |
| Hashimoto, Y; Inui, K; Okuda, M; Takami, K; Uwai, Y | 1 |
| Costa, LG; Guizzetti, M; Wei, M | 1 |
| Brodie, C; Lazarovici, P; Matsuda, Y; Ovadia, H; Tabakman, R | 1 |
| Hashimoto, T; Hojo, K; Kawamata, T; Maeda, K; Nakai, M; Tanaka, C; Taniguchi, T; Terashima, A | 1 |
| Hiraoka, S; Kitamura, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Tsutsui, S | 1 |
| Fabre, S; Georget, V; Lobaccaro, JM; Lumbroso, S; Poujol, N; Sultan, C; Térouanne, B | 1 |
| Daniel, WG; Garlichs, CD; Mügge, A; Zhang, H | 1 |
| Adams, GE; Hasan, NM; Joiner, MC | 1 |
| Cogolludo, A; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Aragay, AM; Quick, MW | 1 |
| Boussard, P; Chaïb, N; Dehaye, JP; Devleeschouwer, M; Kabré, E; Mérino, G | 1 |
| Daniel, H; Diehl, D; Herget, M; Kuntz, S; Wenzel, U | 1 |
| García-Sáinz, JA; Torres-Padilla, ME | 1 |
| Bigas, A; Chernukhin, IV; Delgado, MD; Klenova, EM; León, J | 1 |
| Lan, L; Wong, NS | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Kansra, SV; Reddy, MA; Shukla, SD; Weng, YI | 1 |
| Brown, JF; Chang, Q; Soper, BD; Tepperman, BL | 1 |
| Han, HJ; Koh, HJ; Park, SH | 1 |
| Boarder, MR; Rosário, LM; Santos, RM; Sena, CM | 1 |
| Paramio, JM | 1 |
| Shackelford, RE | 1 |
| Kim, SW; Levine, RA; Loo, A; Nandi, J | 1 |
| Inagaki, N; Kimata, M; Miura, T; Nagai, H; Serizawa, I; Shichijo, M | 1 |
| Banerjee, A; Harken, AH; McIntyre, RC; Meldrum, DR; Meng, X; Pulido, EJ; Selzman, CH; Shames, BD | 1 |
| Dugué, B; Titievsky, A; Törnquist, K; Tuominen, R; Vainio, P | 1 |
| Lin, CN; Lin, PL; Raung, SL; Tsao, LT; Wang, JP | 1 |
| Betancourt-Calle, S; Bollinger Bollag, W; Griner, RD; Jung, EM; Mann-Blakeney, R | 1 |
| Chen, R; Liang, N | 1 |
| Abrams, K; Claffey, KP; Mukhopadhyay, D; Mullen, A; Shih, SC | 1 |
| Kodama, H; Seto, K; Sugahara, K; Ushikoshi, I; Ushikoshi, S; Zhang, J | 1 |
| Bringmann, A; Reichenbach, A; Schopf, S | 1 |
| Alvarez, LJ; Candia, OA; Turner, HC; Zamudio, AC | 1 |
| Salzman, AL; Szabó, C; Wilson, L | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Aoyama, Y; Kitajima, Y; Owada, MK | 1 |
| Chiu, CT; Fan, LW; Tsao, HL; Wang, CC; Yang, CM | 1 |
| Bertorello, AM; Efendiev, R; Pedemonte, CH | 1 |
| Dietz, R; Haller, H; Li, PF; Maasch, C; von Harsdorf, R | 1 |
| Baudouin, C; Brignole, F; De Saint Jean, M; Feldmann, G; Goguel, A | 1 |
| Clase, KL; Elliott, MS; Galicia, MC; Morris, RC | 1 |
| Ford, BD; Ivy, MT; Mtshali, CP; Townsel, JG | 1 |
| Boucher, W; Mak, L; Theoharides, TC; Vliagoftis, H | 1 |
| Ajenjo, N; Berciano, M; Calés, C; Cañelles, M; Ceballos, E; Crespo, P; Delgado, MD; Gutierrez, P; Gutkind, S; León, J; Lerga, A; Richard, C | 1 |
| Arias-Montaño, JA; Bahena-Trujillo, R | 1 |
| Chang, SH; Lin, WW; Wang, SM | 1 |
| Chang, Q; Soper, BD; Tepperman, BL | 1 |
| Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U | 1 |
| Amara, SG; Daniels, GM | 1 |
| Knox, FG; Liang, M | 1 |
| Florio, T; Giordano, G; Giusti, M; Schettini, G; Thellung, S; Valenti, S | 1 |
| Coronel, R; Dekker, LR; Opthof, T; Spaan, JA; VanBavel, E | 1 |
| Goldenberg, H; Laggner, H | 1 |
| Josefsen, D; Myklebust, JH; Sioud, M; Smeland, EB | 1 |
| Bosch, RJ; Díez-Marqués, ML; García-Escribano, C; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Torrecillas, G | 1 |
| Chiu, CT; Huang, SC; Lin, CC; Pan, SL; Tsai, YJ; Wang, CC; Wu, WB; Yang, CM | 1 |
| Kim, JY; Lee, SH; Moon, CH; Woo, HG | 1 |
| Dartt, DA; Hodges, RR; Sergheraert, C; Zoukhri, D | 1 |
| Alcántara-Hernández, R; Gárcia-Sáinz, JA; Vázquez-Prado, J | 1 |
| Drexler, HG; Meyer, C; Steube, KG | 1 |
| Chang, YS; Dull, RO; Gardner, TW; Hillsley, MV; Jain, RK; Lakshminarayanan, S; Munn, LL; Tarbell, JM; Yuan, J | 1 |
| Brown, JF; Chang, Q; Soper, BD; Tepperman, BL; Wakulich, CA | 1 |
| Hayden, MR; Mujumdar, VS; Tyagi, SC | 1 |
| Alexander, SR; Kishimoto, TK; Walcheck, B | 1 |
| Danker, K; Effertz, K; Horstkorte, R; Lucka, L; Nöhring, S; Reutter, W | 1 |
| Bergman, M; Chentoufi, J; Gray, M; Honbo, NY; Karliner, JS; Piacentini, L | 1 |
| Husted, RF; Snyder, PM; Stokes, JB; Volk, KA | 1 |
| Courtois, G; Israël, A; Schwamborn, K; Weil, R; Whiteside, ST | 1 |
| Allen, JC; Kahn, AM; Seidel, CL; Song, T | 1 |
| Tai, HH; Tong, M | 1 |
| Fukushima, A; Hashida, M; Kodama, H; Ueno, H; Zhang, J | 1 |
| Albig, W; Doenecke, D; Hanecke, K; Kratzmeier, M | 1 |
| Kajiya, H; Okabe, K; Okamoto, F; Soeda, H; Takada, K | 1 |
| Dunzendorfer, S; Wiedermann, CJ | 1 |
| Kataoka, K; Nakamura, Y; Si, Q | 1 |
| Chen, CC; Chen, JJ; Chiu, KT; Sun, YT | 1 |
| Benítez-King, G | 1 |
| Chung, HT; Kim, SB; Lee, HS; Pae, HO; Seo, WG; Shin, M | 1 |
| Cousin, MA; Robinson, PJ | 1 |
| Chae, SW; Cho, CH; Jo, SH; Lee, CO | 1 |
| Huang, HC; Nguyen, T; Pickett, CB | 1 |
| Cunningham, FM; Goode, NT; Greenaway, EC | 1 |
| Kobayashi, S; Kumagai, M; Makioka, A; Ohtomo, H; Takeuchi, T | 1 |
| Mancuso, P; Peters-Golden, M | 1 |
| Asghar, M; Hussain, T; Lokhandwala, MF | 1 |
| Katsuyama, R; Kawasaki, T; Morioka, A; Oka, S | 1 |
| Ivy, MT; Karim, MR; Mtshali, CM; Newkirk, RF; Townsel, JG | 1 |
| Asbóth, G; Barlow, DH; Bellinger, J; Bernal, AL; Ledger, W; Price, SA | 1 |
| Billardon, C; Carvajal-Gonzalez, S; Gompel, A; Kandouz, M; Lombet, A; Rostène, W; Zujovic, V | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Blagosklonny, MV; Dixon, SC; Figg, WD; Robey, R | 1 |
| Higashiyama, M; Honda, K; Ishikawa, S; Kusaka, I; Nagasaka, S; Nakamura, T; Saito, T | 1 |
| Naber, T; van Emst-De Vries, S; Wanten, G; Willems, P | 1 |
| Crook, RB; Layne, J; Yip, S | 1 |
| Giannella, RA; Guruprasad, MR; Kondaiah, P; Mann, EA; Roy, N; Visweswariah, SS | 1 |
| Herrera, R; Petruzzelli, L; Takami, M | 1 |
| Blauvelt, A; Davis, DA; Moses, AV; Orenstein, JM; Overwijk, WW; Rinderknecht, AS; Yarchoan, R; Zoeteweij, JP | 1 |
| Idei, T; Igarashi, N; Kikuchi, A; Matukawa, T; Nakayama, Y; Ohtani, K; Sakamoto, H; Satoh, K | 1 |
| Amit, T; Barkey, RJ; Hochberg, Z; Yogev-Falach, M; Youdim, MB | 1 |
| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
| Chang, MY; Kim, JH; Kim, YS; Lee, KH; Lee, SH; Lee, YS; Son, H | 1 |
| Haugen, KE; Johannessen, LE; Madshus, IH; Stang, E; østvold, AC | 1 |
| Day, ML; Zhao, X | 1 |
| Balla, Z; Edes, I; Ferdinandy, P; Flameng, W; Mubagwa, K; Pongo, E; Szilvassy, Z | 1 |
| Beales, IL; Calam, J | 1 |
| Rabkin, SW | 1 |
| Kitahara, M; Naitoh, T; Tsuruzoe, N | 1 |
| Jiang, L; Kang, J; Nedergaard, M; Xu, J | 1 |
| Chen, JS; Song, JG | 1 |
| Choi, KC; Kang, SK; Leung, PC; Tai, CJ; Tzeng, CR | 1 |
| Fong, WF; Lam, W; Leung, CH; Wong, NS; Yang, MS; Zhuang, WJ | 1 |
| Arenson, MS; Evans, SC | 1 |
| Banerjee, PR; Bhadra, R; Deshpande, M; Mitra, D; Mitra, DK; Pal, S; Parab, P; Prasad, DV; Saha, B; Sharma, S; Venuprasad, K | 1 |
| Chiu, CT; Pan, SL; Tsai, YJ; Wang, CC; Wu, W; Yang, CM | 1 |
| Costa, LG; Guizzetti, M; Lu, H | 1 |
| Gauvreau, G; MacGlashan, DW; Miura, K; Saini, SS | 1 |
| Inaguma, Y; Ito, H; Iwamoto, I; Kato, K; Lida, K | 1 |
| Li, Z; Murthy, VN | 1 |
| Conquer, JA; Cruz, TF; Jones, SA | 1 |
| Cogolludo, AL; Fajardo, S; Ibarra, M; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Akaike, N; Cho, YW; Han, SH; Min, BI; Rhee, JS | 1 |
| Morisco, C; Sadoshima, J; Seta, K; Vatner, SF; Yamamoto, S | 1 |
| Balaraman, S; Kapoor, P; Madhubala, R; Raj, VS; Saxena, S | 1 |
| Adams, JM; Jackson, BA; Jorgensen, MS; Liu, J; Titlow, WB | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Chen, H; Pan, YX; Webb, KE; Wong, EA | 1 |
| Lange, Y; Steck, TL; Ye, J | 1 |
| Clark, SS; Elegbede, JA; Jenkins, GJ; Perman, SM; Sahin, MB | 1 |
| Ma, ZJ; Yamaguchi, M | 1 |
| Costa, S; Fages, C; Monville, C; Paillaud, E; Plassat, JL; Rochette-Egly, C; Tardy, M | 1 |
| Hashimoto, N; Morita, T; Nezu, A; Tanimura, A; Tojyo, Y | 1 |
| Gaudreau, R; Le Gouill, C; Rola-Pleszczynski, M; Stankova, J; Venne, MH | 1 |
| Chen, TC; Couldwell, WT; Gopalakrishna, R; Hinton, DR; Law, RE; Simard, M; Su, YZ; Weiss, MH; Zhang, W | 1 |
| Adashi, EY; Chamoun, D; Choi, D; Levitas, E; Resnick, CE; Rosenfeld, RG; Tavares, AB; Udoff, LC | 1 |
| Ho, YS; Lee, WS; Liang, YC; Lin, SY; Pan, S; Tsai, SH | 1 |
| Lai, ZS; Ma, Q; Wang, QY; Zhang, YL; Zhang, ZS | 1 |
| Andrews, DA; Low, PS; Yang, L | 1 |
| Ban, HS; Kim, YP; Lee, S; Ohuchi, K; Shin, KH; Yamaki, K | 1 |
| Exton, JH; Hu, T | 1 |
| Fladeby, C; Grønning, M; Serck-Hanssen, G; Skar, R | 1 |
| Agalakova, NI; Gusev, GP | 1 |
| Murakami, K; Nakamura, Y; Ohmaki, M; Yoneda, Y | 1 |
| Bazuine, M; Bosch, RR; Hermus, AR; Maassen, JA; Olthaar, AJ; Schürmann, A; Span, PN; Sweep, CG; Wake, MM; Willems, PH | 1 |
| Campos de Carvalho, AC; Cristancho, JM; Fortes, FS; Franci, CR; Goldenberg, RC; Morales, MM; Varanda, WA | 1 |
| Bacon, BR; Britton, RS; Li, L; O'Neill, R; Ramm, GA | 1 |
| Abe, M; Endoh, T; Suzuki, T | 1 |
| Hsu, CC; Huang, BM; Huang, YL; Tsai, SJ | 1 |
| Atweh, GF; French, DL; Rubin, CI | 1 |
| Litvinov, DY; Zabazarnykh, MY | 1 |
| Alberti, I; Auberger, P; Bernard, A; Charvet, C; Deckert, M; Jacquel, A; Luciano, F | 1 |
| Hahn, D; Hansen, MK; Leuenberger, B; Luginbuehl, U; Pischitzis, A; Roesmann, S; Sterchi, EE | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Clapp, LH; Cui, Y; Giblin, JP; Quinn, KV; Tinker, A | 1 |
| Buhlmann, C; Chan, SD; Luedke, G; Preckel, T; Valer, M | 1 |
| Cho, JY; Chun, T; Hong, S; Jung, JH; Kim, AR; Kim, SH; Rhee, MH; Yoo, ES | 1 |
| Fabbro, M; Nair, SV; Raftos, DA | 1 |
| John, SA; Kodama, I; Lee, JK; Uozumi, N; Zhang, L | 1 |
| Bird, PS; Seymour, GJ; Sosroseno, W | 1 |
| Kim, CH; Kim, HM; Park, SY; Park, WH | 1 |
| Aoki, M; Haramaki, N; Ikeda, H; Imaizumi, T; Katoh, A; Murohara, T; Otsuka, Y; Takajo, Y | 1 |
| Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L | 1 |
| Bristulf, J; Owman, C; Sabirsh, A | 1 |
| Bełtowski, J; Borkowska, E; Jamroz-Wiśniewska, A; Marciniak, A; Wójcicka, G | 1 |
| Cederbaum, AI; Jimenez-Lopez, JM | 1 |
| Hirade, K; Ishisaki, A; Katagiri, Y; Kato, K; Kozawa, O; Nakajima, K; Nakamura, M; Niwa, M; Sugiyama, T; Tanabe, K | 1 |
| Battu, S; Beneytout, JL; Cardot, PJ; Léger, DY; Liagre, B | 1 |
| Hisano, N; Igarashi, Y; Nakahara, K; Ozaki, Y; Yamamura, S; Yatomi, Y | 1 |
| de Widt, J; Divecha, N; van Baal, J; van Blitterswijk, WJ | 1 |
| Chang, RL; Conney, AH; Hansson, A; Huberman, E; Klemons, S; Lin, Y; Patel, N; Ryan, A; Shih, WJ; Zheng, X | 1 |
| Hartelt, N; Ivannikov, MV; Mironov, SL | 1 |
| Inoue, R; Shiraishi, T | 1 |
| Barac-Nieto, M; Silverstein, DM; Spitzer, A | 1 |
| Acosta, TJ; Bah, MM; Korzekwa, A; Okuda, K; Shibaya, M; Skarzynski, DJ; Woclawek-Potocka, I | 1 |
| Heo, KS; Lim, KT | 1 |
| Liu, L; Xu, J | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B | 1 |
| Ikeda, M; Kadoi, J; Mastumoto, S; Nakano, Y; Yoshida, S | 1 |
| Bandobashi, K; Kobayashi, M; Kubota, T; Nakata, H; Saito, T; Taguchi, H; Uemura, Y | 1 |
| Ebel, H; Günther, T | 1 |
| Do, SH; Kim, HK; Kim, JH; Lim, YJ; Yun, JY; Zuo, Z | 1 |
| Drenckhahn, D; Golenhofen, N; Kurzchalia, TV; Waschke, J | 1 |
| Canaff, L; Chihara, K; Hendy, GN; Kaji, H; Naito, J; Sowa, H; Sugimoto, T; Tobimatsu, T | 1 |
| Bober, A; Korzekwa, A; Okuda, K; Skarzynski, DJ; Woclawek-Potocka, I | 1 |
| Gong, Z; Tanguay, RM; Wang, F; Wei, Q; Wu, T; Yang, J; Yang, M | 1 |
| Lin, MW; Wang, YJ; Wu, SN | 1 |
| Do, SH; Kim, JH; Park, KS; Yun, JY; Zuo, Z | 1 |
| Akabane, H; Fan, J; Zheng, X; Zhu, GZ | 1 |
| Berg, DT; Calnek, D; Grinnell, BW; Gupta, A; O'Brien, LA; Richardson, MA | 1 |
| Kazi, JU; Soh, JW | 1 |
| Wu, ZX; Xia, H; Xu, L; Yu, BP | 1 |
| Adolfo García-Sáinz, J; Alcántara-Hernández, R | 1 |
| Furuchi, T; Homma, H; Katane, M; Sekine, M; Suzuki, T | 1 |
| Chang, CJ; Chen, MT; Chen, SE; Chiang, CC; Nagahata, H; Peh, HC; Yu, B | 1 |
| McNaughton, PA; Studer, M | 1 |
| Ceballos, NR; Volonteri, MC | 1 |
| Arnaldo, FB; Concepcion, GP; Felder, RA; Han, W; Jose, PA; Li, H; Quinn, MT; Villar, VA; Yu, P | 1 |
| Aguiar, JF; Costa, RR; Reis, RI; Varanda, WA | 1 |
| Chieng, YC; Hoon, LS; Hsum, YW; Mooi, LY; Soo, KK; Yew, WT | 1 |
| Tseng, CL; Wei, JW | 1 |
| Few, LL; Kuan, CS; See Too, WC; Yee, YH | 1 |
| Beltramini, M; Bisaglia, M; Bubacco, L; Civiero, L; Codolo, G; Ferrari, V; Filograna, R; Greggio, E | 1 |
| Cao, YJ; Du, WX; Huang, YB; Liu, CF; Liu, HH; Shi, LY; Sun, JJ; Wang, F; Yin, XW; Zhang, YL | 1 |
| Carillo, V; Cirone, M; D'Orazi, G; Faggioni, A; Gaeta, A; Gonnella, R; Granato, M; Nazzari, C; Romeo, MA; Santarelli, R | 1 |
1 review(s) available for staurosporine and tetradecanoylphorbol acetate
| Article | Year |
|---|---|
Is TNF involved in the progression of AIDS?
Topics: Acquired Immunodeficiency Syndrome; Alkaloids; Base Sequence; Gene Expression Regulation; HIV; Humans; Molecular Sequence Data; Mutation; Repetitive Sequences, Nucleic Acid; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virus Replication | 1990 |
1144 other study(ies) available for staurosporine and tetradecanoylphorbol acetate
| Article | Year |
|---|---|
Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Calcitonin; Calcitonin Gene-Related Peptide; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Epithelium; Eye; Fetus; Humans; Kinetics; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Calcimycin; Carrier Proteins; Cell Division; Cycloheximide; Endometrial Neoplasms; Enzyme Activation; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor Binding Proteins; Kinetics; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1992 |
Further evidence from an elastic artery that angiotensin II amplifies noradrenaline-induced contraction through activation of protein kinase C.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction | 1992 |
Inhibition of protein kinases in rat pheochromocytoma (PC12) cells promotes morphological differentiation and down-regulates ion channel expression.
Topics: Alkaloids; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Down-Regulation; Ion Channels; Kinetics; Nerve Growth Factors; omega-Conotoxins; PC12 Cells; Peptides, Cyclic; Protein Kinase Inhibitors; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation.
Topics: Actins; Adrenal Medulla; Alkaloids; Animals; Calcium; Cattle; Enzyme Activation; Exocytosis; Kinetics; Macromolecular Substances; Microscopy, Fluorescence; Naphthalenes; Nicotine; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Receptors, Nicotinic; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C modulates the release of [3H]5-hydroxytryptamine in the spinal cord of the rat: the role of L-type voltage-dependent calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium Channel Blockers; Calcium Channels; Enzyme Activation; In Vitro Techniques; Male; Nerve Tissue Proteins; Nitrendipine; omega-Conotoxins; Peptides, Cyclic; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1992 |
Staurosporine and calphostin-C inhibit the phorbol ester-induced decrease of protein kinase C activity in rat hepatocytes.
Topics: Alkaloids; Animals; Chromatography, DEAE-Cellulose; Enzyme Activation; Female; Liver; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Signal transduction by HLA class II molecules in human T cells: induction of LFA-1-dependent and independent adhesion.
Topics: Alkaloids; Antigens, CD; Aphidicolin; Benzoquinones; Cell Adhesion; Cell Line; Colchicine; Cold Temperature; Cytochalasin B; Cytochalasins; Dideoxyadenosine; Dose-Response Relationship, Drug; Edetic Acid; HLA-DR Antigens; Humans; Lactams, Macrocyclic; Lymphocyte Function-Associated Antigen-1; Mitomycin; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1992 |
The possible involvement of protein kinase C(s) and inositol phosphate metabolism in the basal but not in the prolactin stimulated casein release by the lactating rabbit mammary epithelial cell.
Topics: Alkaloids; Animals; Caseins; Diglycerides; Enzyme Activation; Epithelium; Female; Inositol Phosphates; Lactation; Mammary Glands, Animal; Prolactin; Protein Kinase C; Quercetin; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Regulation of formyl peptide receptor expression and its mRNA levels during differentiation of HL-60 cells.
Topics: Alkaloids; Binding Sites; Bucladesine; Cell Differentiation; Chromatography, Liquid; Colforsin; Dexamethasone; Drug Antagonism; Gene Expression Regulation; Humans; Protein Kinase C; Protein Kinases; Receptors, Formyl Peptide; Receptors, Immunologic; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1992 |
Modulation of 1,25-dihydroxyvitamin D3-dependent Ca2+ uptake in skeletal muscle by protein kinase C.
Topics: Alkaloids; Animals; Calcitriol; Calcium; Chickens; Cyclic AMP; Kinetics; Muscles; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Effects of staurosporine, PMA and A23187 on human melanocyte cultures with dibutyryl cyclic AMP.
Topics: Adult; Alkaloids; Bucladesine; Calcimycin; Cells, Cultured; Humans; Male; Melanocytes; Membrane Glycoproteins; Microscopy, Fluorescence; Monophenol Monooxygenase; Oxidoreductases; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Interleukin 1 and phorbol 12-myristate 13-acetate induce collagenase and PGE2 production through a PKC-independent mechanism in chondrocytes.
Topics: Alkaloids; Animals; Arachidonic Acid; Cartilage, Articular; Cattle; Cell Compartmentation; Cells, Cultured; Dinoprostone; Enzyme Induction; Interleukin-1; Microbial Collagenase; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Carrier Proteins; Cell Death; Clone Cells; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Isoquinolines; Kinetics; Leukemia, Megakaryoblastic, Acute; Piperazines; Protein Kinase C; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoquinolines; Liver Neoplasms; Oxygen; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured | 1992 |
Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone.
Topics: Alkaloids; Animals; Bone Resorption; Calcitriol; Calcium; Cells, Cultured; Diglycerides; Hydroxyurea; Kinetics; Osteoblasts; Osteocalcin; Protein Kinase C; Rats; Receptors, Calcitriol; Receptors, Steroid; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1992 |
Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production.
Topics: Alkaloids; Animals; Biological Transport; Bone Marrow Cells; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Endotoxins; Granulocyte-Macrophage Colony-Stimulating Factor; Inositol Phosphates; Iodine Radioisotopes; Macrophages; Mice; Mice, Inbred CBA; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Effect of staurosporine on fMet-Leu-Phe-stimulated human neutrophils: dissociated release of inositol 1,4,5-trisphosphate, diacylglycerol and intracellular calcium.
Topics: Alkaloids; Calcium; Diglycerides; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Modulation of cardiac Ca2+ channels in Xenopus oocytes by protein kinase C.
Topics: Alkaloids; Animals; Calcium Channels; Cells, Cultured; Cloning, Molecular; Kinetics; Myocardium; Oocytes; Protein Kinase C; Rabbits; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus | 1992 |
Control of insulin gene expression by glucose.
Topics: Alkaloids; Blotting, Northern; Bucladesine; Cell Line; Chimera; Chloramphenicol O-Acetyltransferase; Colforsin; Enhancer Elements, Genetic; Gene Expression Regulation; Glucose; Insulin; Islets of Langerhans; Proinsulin; Promoter Regions, Genetic; Protein Kinase C; Protein Kinases; Protein Precursors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Verapamil | 1992 |
Connexin43 in MDCK cells: regulation by a tumor-promoting phorbol ester and Ca2+.
Topics: Alkaloids; Animals; Calcium; Cell Adhesion; Cell Communication; Cell Membrane Permeability; Cells, Cultured; Connexins; Dogs; Ethers, Cyclic; Immunohistochemistry; Intercellular Junctions; Ionophores; Membrane Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinases; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Isoproterenol-induced Mg2+ uptake in liver.
Topics: Alkaloids; Animals; Bucladesine; Cations, Divalent; Enzyme Activation; In Vitro Techniques; Isoproterenol; Liver; Magnesium; Male; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line.
Topics: Alkaloids; Amino Acids; Biological Transport; Calmodulin; Choriocarcinoma; Cyclic AMP; Female; Humans; Kinetics; Pregnancy; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Neoplasms | 1992 |
Evidence that activation of protein kinase-C can stimulate 1,25-dihydroxyvitamin D3 secretion by rat proximal tubules.
Topics: Alkaloids; Analysis of Variance; Animals; Calcimycin; Calcitonin; Calcitriol; Cyclic AMP; Enzyme Activation; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Male; Parathyroid Hormone; Peptide Fragments; Perfusion; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Teriparatide; Tetradecanoylphorbol Acetate | 1992 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Activation of protein kinase C modulates dihydroxycholecalciferol synthesis in rat renal tubules.
Topics: Alkaloids; Animals; Calcitriol; Cell Membrane; Cholecalciferol; Cholestanetriol 26-Monooxygenase; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Kidney Tubules; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Steroid Hydroxylases; Tetradecanoylphorbol Acetate | 1992 |
Effect of protein kinase C inhibitors with different action mechanisms on Epstein-Barr virus replication.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; DNA, Viral; Herpesvirus 4, Human; Isoquinolines; Nucleic Acid Hybridization; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
The long-term combined stimulatory effects of ethanol and phorbol ester on phosphatidylethanolamine hydrolysis are mediated by a phospholipase C and prevented by overexpressed alpha-protein kinase C in fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Enzyme Activation; Ethanol; Ethanolamines; Ethers, Cyclic; Fibroblasts; Hydrolysis; Isoenzymes; Isoquinolines; Mice; Mice, Inbred BALB C; Okadaic Acid; Phosphatidylethanolamines; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Protein kinase C involved in zymosan-induced release of arachidonic acid and superoxide but not in calcium ionophore-elicited arachidonic acid release or formation of prostaglandin E2 from added arachidonate.
Topics: Alkaloids; Animals; Arachidonic Acids; Blotting, Western; Calcimycin; Carbazoles; Cells, Cultured; Dinoprostone; Indole Alkaloids; Kupffer Cells; Male; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Two different signal transductions of neuropeptide Y1 receptor in SK-N-MC cells.
Topics: Alkaloids; Calcium; Colforsin; Cyclic AMP; Diglycerides; Humans; In Vitro Techniques; Neuropeptide Y; Pertussis Toxin; Receptors, Neuropeptide Y; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Phorbol ester-like action of staurosporine on the cAMP response to prostaglandin E2 in two macrophage-like cell lines at distinct differentiation stages.
Topics: Alkaloids; Animals; Cell Differentiation; Cell Line; Culture Media; Cyclic AMP; Dinoprostone; Macrophages; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Angiotensin II potentiates agonist-induced 3',5'-cyclic adenosine monophosphate production by cultured bovine adrenal cells through protein kinase C and calmodulin pathways.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Alkaloids; Angiotensin II; Animals; Calcium Channels; Calmodulin; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrocortisone; Nifedipine; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Trifluoperazine | 1992 |
Differential effects on neutrophil activation of staurosporin and its protein kinase C-selective derivative cgp 41231.
Topics: Alkaloids; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Eflornithine; Gene Expression; Genes, jun; Genistein; GTP-Binding Proteins; Insulin; Isoflavones; Kinetics; Mice; Pertussis Toxin; Polyamines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Putrescine; Signal Transduction; Simian virus 40; Spermidine; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella | 1992 |
Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta, Thoracic; Biological Factors; Bucladesine; Cell Division; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fibronectins; Isoquinolines; Kinetics; Macromolecular Substances; Muscle, Smooth, Vascular; Pertussis Toxin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Wistar; Recombinant Proteins; Second Messenger Systems; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Virulence Factors, Bordetella | 1992 |
Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells.
Topics: Alkaloids; Cell Membrane; Cells, Cultured; Chloroquine; Down-Regulation; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Etorphine; In Vitro Techniques; Naloxone; Narcotics; Neurons; Protein Kinase C; Receptors, Opioid, delta; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.
Topics: Alkaloids; Animals; Blotting, Western; Cell Line; Chloroquine; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Interleukin-5; Isoflavones; Kinetics; Ligands; Macromolecular Substances; Mice; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Interleukin-3; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1992 |
Mechanisms of activation of Na+/H+ exchange in human osteoblast-like SaOS-2 cells.
Topics: Alkaloids; Calcium; Carrier Proteins; Cell Line; Cytosol; Egtazic Acid; Fluoresceins; Fluorescent Dyes; Fura-2; Humans; Hydrogen-Ion Concentration; Ionomycin; Nigericin; Osmotic Pressure; Osteoblasts; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Vasopressin elevation of Na+/H+ exchange is inhibited by genistein in human blood platelets.
Topics: Adult; Alkaloids; Arginine Vasopressin; Blood Platelets; Carrier Proteins; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Middle Aged; Phosphorylation; Protein Kinase C; Protons; Sodium; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida | 1992 |
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Possible involvement of protein kinase C and calcium in GSH efflux from Hep G2 cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Carcinoma, Hepatocellular; Glutathione; Humans; Liver Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1992 |
PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms.
Topics: Alkaloids; Animals; Arginine Vasopressin; Cells, Cultured; Cyclic AMP; Dinoprostone; Kidney Cortex; Kidney Tubules, Collecting; Pertussis Toxin; Prostaglandins; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1992 |
Stimulation of early gene expression by angiotensin II in bovine adrenal glomerulosa cells: roles of calcium and protein kinase C.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adrenocorticotropic Hormone; Alkaloids; Angiotensin II; Animals; Base Sequence; Calcium; Cattle; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Genes, fos; Genes, jun; Imidazoles; Ionomycin; Molecular Sequence Data; Protein Kinase C; Pyridines; Staurosporine; Stimulation, Chemical; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Zona Glomerulosa | 1992 |
Serotonergic signalling between thyroid cells: protein kinase C and 5-HT2 receptors in the secretion and action of serotonin.
Topics: Alkaloids; Amphetamines; Animals; Antibodies; Calcium; Cell Line; Cyclic AMP; Immunoglobulin Idiotypes; Phosphatidylinositols; Protein Kinase C; Rats; Receptors, Serotonin; Serotonin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland; Tumor Cells, Cultured | 1992 |
The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Alkaloids; Animals; Calcium; Carbohydrate Sequence; Cell Adhesion; Colon; Colonic Neoplasms; Entamoeba histolytica; Enzyme Activation; Humans; Intestinal Mucosa; Isoquinolines; Lectins; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Sequence Data; Mucins; Neoplasm Proteins; Piperazines; Protein Kinase C; Protozoan Proteins; Secretory Rate; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
PKC-independent inhibition of glutamate exocytosis by arachidonic acid in rat cerebrocortical synaptosomes.
Topics: Alkaloids; Animals; Arachidonic Acids; Cerebral Cortex; Enzyme Activation; Exocytosis; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Protein Kinase C; Rats; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1992 |
Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cell Adhesion Molecules; Cell Survival; Cytokines; Drug Synergism; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Ionomycin; Isoquinolines; Lipopolysaccharides; Piperazines; Protein Biosynthesis; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Staurosporine induces a neuronal phenotype in SH-SY5Y human neuroblastoma cells that resembles that induced by the phorbol ester 12-O-tetradecanoyl phorbol-13 acetate (TPA).
Topics: Alkaloids; Blotting, Northern; Blotting, Western; Cell Differentiation; GAP-43 Protein; Gene Expression Regulation; Humans; Membrane Glycoproteins; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1992 |
The differentiation pathway of HL60 cells is a model system for studying the specific regulation of some myeloid genes.
Topics: Actins; Alkaloids; Antigens, CD; Base Sequence; CD18 Antigens; Cell Differentiation; Dactinomycin; Gene Expression Regulation, Leukemic; Granulocytes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Male; Molecular Sequence Data; Monocytes; Muramidase; Neoplasm Proteins; Neoplastic Stem Cells; Peroxidase; Protein Kinase C; RNA, Neoplasm; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Coloring Agents; Diglycerides; Drug Resistance; Gene Expression Regulation, Neoplastic; Glycerol; Humans; Lymphocytes; Membrane Glycoproteins; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Topics: Alkaloids; Antigens, Neoplasm; Biomarkers, Tumor; Calcimycin; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Humans; Male; Nandrolone; Phorbols; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Staurosporine; Testosterone Congeners; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Relationship between cytosolic Ca2+ concentration and amylase release in rat parotid acinar cells following muscarinic stimulation.
Topics: Alkaloids; Amylases; Animals; Calcium; Carbachol; Cytosol; Dose-Response Relationship, Drug; Egtazic Acid; Gallic Acid; Ionomycin; Male; Parotid Gland; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes.
Topics: Actins; Alkaloids; Animals; Calcium; Cell Membrane; Dictyostelium; Diglycerides; Kinetics; Macromolecular Substances; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Endocytosis is regulated by protein kinase A, but not protein kinase C in a secretory epithelial cell line.
Topics: Alkaloids; Animals; Calcium; Cell Line; Chlorides; Colforsin; Cyclic AMP; Dextrans; Diglycerides; Endocytosis; Epithelium; Fluorescein-5-isothiocyanate; Homeostasis; Horseradish Peroxidase; Kinetics; Protein Kinase C; Protein Kinases; Second Messenger Systems; Staurosporine; Temperature; Tetradecanoylphorbol Acetate | 1992 |
A novel IgA receptor expressed on a murine B cell lymphoma.
Topics: Alkaloids; Animals; Binding, Competitive; Cycloheximide; Down-Regulation; Hydrogen-Ion Concentration; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; In Vitro Techniques; Ionomycin; Lymphocyte Activation; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Naphthalenes; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Polycyclic Compounds; Protein Kinase C; Receptors, Fc; Receptors, Immunologic; Rosette Formation; Secretory Component; Staurosporine; Tetradecanoylphorbol Acetate; Trypsin; Tumor Cells, Cultured | 1992 |
Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Ethers, Cyclic; Humans; KB Cells; Membrane Glycoproteins; Naphthalenes; Okadaic Acid; Peptide Mapping; Phenotype; Phospholipid Ethers; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Vinblastine | 1992 |
The role of calcium and protein kinase C in the IgE-dependent activation of phosphatidylcholine-specific phospholipase D in a rat mast (RBL 2H3) cell line.
Topics: Alkaloids; Animals; Calcium; Cell Line; Enzyme Activation; Histamine Release; Immunoglobulin E; Indoles; Ionomycin; Kinetics; Maleimides; Mast Cells; Phospholipase D; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells.
Topics: Alkaloids; Astrocytoma; Brain Neoplasms; Down-Regulation; Humans; Hydrolysis; Phosphatidylinositols; Protein Kinase C; Receptors, Neurotransmitter; Receptors, Tachykinin; Staurosporine; Substance P; Tachykinins; Taurine; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured | 1992 |
Activation of protein kinase C is not an absolute requirement for amylase release from permeabilized rat pancreatic acini.
Topics: Alkaloids; Amylases; Animals; Calcium; Cations, Divalent; Cyclic AMP; Enzyme Activation; Male; Pancreas; Peptides; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Components of the protein kinase C pathway induce Ia expression after injection into macrophages.
Topics: Alkaloids; Animals; Calcimycin; Diglycerides; Histocompatibility Antigens Class II; In Vitro Techniques; Interferon-gamma; Isoquinolines; Macrophages; Mice; Mice, Inbred C3H; Microinjections; Naphthalenes; Phospholipases A; Phospholipases A2; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
The roles of calmodulin and protein kinase C in histamine secretion from mast cells.
Topics: Alkaloids; Animals; Calmodulin; Diglycerides; Histamine Release; In Vitro Techniques; Male; Mast Cells; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells.
Topics: Alkaloids; Blotting, Northern; Cinnamates; Colforsin; Cycloheximide; Gene Expression; Genes, fos; Genistein; Humans; Isoflavones; Platelet Activating Factor; Protein Kinase C; Protein-Tyrosine Kinases; RNA; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Decreased protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes.
Topics: Alkaloids; Animals; Apoptosis; Bleomycin; DNA; In Vitro Techniques; Kinetics; Liver; Male; Polymyxin B; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Rapid regulation of albumin transcription by insulin and phorbol esters in rat hepatoma cells.
Topics: Albumins; Alkaloids; Animals; Cycloheximide; Gene Expression Regulation; Insulin; Kinetics; Liver Neoplasms, Experimental; Naphthalenes; Phosphoenolpyruvate Carboxykinase (GTP); Polycyclic Compounds; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Actions of two native GnRHs and protein kinase C modulators on goldfish pituitary cells. Studies on intracellular calcium levels and gonadotropin release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Fluorescence; Fura-2; Goldfish; Gonadotropin-Releasing Hormone; Pituitary Gland; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1992 |
Protein kinase C couples membrane excitation to acetylcholine receptor gene inactivation in chick skeletal muscle.
Topics: Alkaloids; Animals; Cell Membrane; Cell Nucleus; Chickens; Cholinergic Antagonists; DNA, Antisense; Electric Stimulation; Gene Expression Regulation; Kinetics; Macromolecular Substances; Male; Muscles; Protein Kinase C; Receptors, Cholinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1992 |
Differential inhibition by staurosporine of phorbol ester, bryostatin and okadaic acid effects on mouse skin.
Topics: Alkaloids; Animals; Bryostatins; Cyclosporine; Edema; Ethers, Cyclic; Female; Lactones; Macrolides; Mice; Okadaic Acid; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.
Topics: 3T3 Cells; Alkaloids; Animals; Antineoplastic Agents; Cells, Cultured; Epidermal Growth Factor; Gene Expression; Genes, fos; Mice; Mice, Inbred BALB C; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Effect of staurosporine derivatives on IL-1-stimulated prostaglandin E production.
Topics: Alkaloids; Arthritis, Rheumatoid; Cells, Cultured; Fibroblasts; Humans; Interleukin-2; Kinetics; Prostaglandins E; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Synovial Fluid; Tetradecanoylphorbol Acetate | 1992 |
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Colforsin; Diterpenes; Enzyme Activation; Female; Genetic Variation; Kinetics; Ligands; Molecular Sequence Data; N-Methylaspartate; Oligodeoxyribonucleotides; Oocytes; Polyamines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing; Sphingosine; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Xenopus laevis | 1992 |
Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization.
Topics: Actins; Alkaloids; Calcium; Cations, Divalent; Cell Line; Chemotaxis, Leukocyte; GTP-Binding Proteins; Humans; Indoles; Ionomycin; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Polymers; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella | 1992 |
Multiple effects of staurosporine, a kinase inhibitor, on thymocyte functions. Comparison with the effect of tyrosine kinase inhibitors.
Topics: Alkaloids; Animals; Benzylidene Compounds; Calcimycin; Carbazoles; Cell Division; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Indole Alkaloids; Mice; Mice, Inbred BALB C; Nitriles; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Tyrphostins | 1992 |
Effects of Pasteurella haemolytica leukotoxic culture supernatant on bovine neutrophil aggregation.
Topics: Acetophenones; Alkaloids; Animals; Bacterial Toxins; Cattle; Cell Aggregation; Cells, Cultured; Culture Media; Cytotoxins; Exotoxins; Mannheimia haemolytica; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Ca(2+)-independent induction of acrosome reaction by protein kinase C in human sperm.
Topics: Acrosome; Adult; Alkaloids; Calcium; Cell Membrane Permeability; Diglycerides; Down-Regulation; Exocytosis; Female; Humans; Immunohistochemistry; Ionomycin; Male; Microscopy, Electron; Protein Kinase C; Signal Transduction; Sperm Capacitation; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Signal transduction for interleukin-3-dependent leukotriene synthesis in normal human basophils: opposing role of tyrosine kinase and protein kinase.
Topics: Alkaloids; Basophils; Calcium; Cells, Cultured; Complement C5a; GTP-Binding Proteins; Humans; Interleukin-3; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C-dependent and -independent actions of a potent protein kinase C inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epidermal Cells; Epidermis; Indomethacin; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
[Sulfolipids and glycolipid sulfotransferases in a human renal cell carcinoma cell line].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Renal Cell; Epidermal Growth Factor; Humans; Isoquinolines; Kidney Neoplasms; Lipid Metabolism; Lipids; Piperazines; Protein Kinase C; Staurosporine; Sulfotransferases; Sulfurtransferases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cysteine; Dose-Response Relationship, Drug; Endotoxins; Humans; Isoquinolines; Kinetics; Lipopolysaccharides; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Staurosporine; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis.
Topics: Alkaloids; Antigens, CD; Cell Line; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Killer Cells, Natural; Kinetics; Protein Kinase C; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha.
Topics: Acid Phosphatase; Alkaloids; Annexin A1; Cell Adhesion; Cell Compartmentation; Cell Differentiation; Cell Membrane; Esterases; Humans; In Vitro Techniques; Macrophages; Phosphoproteins; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Activators of protein kinase C decrease serotonin transport in human platelets.
Topics: Alkaloids; Biological Transport; Blood Platelets; Diterpenes; Enzyme Activation; Humans; Protein Kinase C; Serotonin; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester activation of the protein kinase C pathway inhibits gonadotropin-releasing hormone gene expression.
Topics: Alkaloids; Animals; Cell Line; DNA Probes; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Gonadotropin-Releasing Hormone; Kinetics; Mice; Nucleic Acid Hybridization; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry.
Topics: Alkaloids; Calcium; Chelating Agents; Cytochalasin B; Egtazic Acid; Flow Cytometry; Fluorescent Dyes; Granulocytes; Humans; Kinetics; Leukocytes, Mononuclear; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Reproducibility of Results; Respiratory Burst; Rhodamines; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1992 |
Steroidogenesis in Fundulus heteroclitus. IV. Dichotomous effects of a phorbol ester on ovarian steroid production and oocyte maturation.
Topics: Alkaloids; Animals; Culture Techniques; Enzyme Activation; Estradiol; Female; Hydroxyprogesterones; Killifishes; Oocytes; Oogenesis; Ovary; Pituitary Gland; Protein Kinase C; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cell Line; Cell Nucleus; Cells, Cultured; Enhancer Elements, Genetic; HIV-1; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; NF-kappa B; Oligonucleotide Probes; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cycloheximide; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein A6; S100 Proteins; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Uterine Neoplasms | 1992 |
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Bryostatins; Down-Regulation; Drug Interactions; Ethers, Cyclic; Hydrolysis; Lactones; Macrolides; Mice; Okadaic Acid; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Inhibition by protein kinase C activation of melittin-induced arachidonic acid release in PC12 pheochromocytoma cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Kinetics; Melitten; Neurons; PC12 Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Characterization of endogenous substrates for novel-type protein kinase C as well as conventional-type protein kinase C in primary cultured mouse epidermal cells.
Topics: Alkaloids; Amino Acids; Animals; Cells, Cultured; Mice; Phosphoproteins; Phosphorylation; Protein Kinase C; Signal Transduction; Skin; Staurosporine; Subcellular Fractions; Substrate Specificity; Tetradecanoylphorbol Acetate | 1992 |
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
Topics: Alkaloids; Androstadienes; Blood Platelets; Blood Proteins; Calcium; Collagen; Humans; Ionomycin; Phosphates; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 1992 |
The protein kinase C activators, phorbol 12-myristate,13-acetate and phorbol 12,13-dibutyrate, are convulsant in the pico-nanomolar range in mice.
Topics: Alkaloids; Animals; Behavior, Animal; Convulsants; Enzyme Activation; Injections, Intraventricular; Male; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Seizures; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Glucocorticoid stimulation of amnion cell prostaglandin synthesis: suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C.
Topics: Alkaloids; Amnion; Cells, Cultured; Dexamethasone; Dinoprostone; Humans; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Acceleration of growth of cultured cardiomyocytes and translocation of protein kinase C.
Topics: Alkaloids; Cell Division; Cell Nucleus; Cells, Cultured; Muscle Proteins; Myocardial Contraction; Myocardium; Norepinephrine; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Translocation, Genetic | 1992 |
Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).
Topics: Actins; Adenosine Triphosphate; Alkaloids; Blood Proteins; Blotting, Western; Calcium; Catechols; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Nitriles; Phospholipids; Phosphoproteins; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Tyrosine Phosphatases; Serotonin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine; Tyrphostins; Vanadates | 1992 |
The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcimycin; Calcium; Cations, Divalent; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Indoles; Maleimides; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; von Willebrand Factor | 1992 |
IL-4 regulation of a protein kinase C independent pathway for the generation of alpha CD3-induced activated killer cells.
Topics: Alkaloids; Animals; Antibodies; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Division; Cells, Cultured; Cytotoxicity, Immunologic; Female; Granzymes; Interleukin-2; Interleukin-4; Killer Cells, Lymphokine-Activated; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Protein Kinase C; Receptors, Antigen, T-Cell; Serine Endopeptidases; Spleen; Staurosporine; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bombesin; Calcium; Calcium-Transporting ATPases; Carbon Radioisotopes; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolysis; Kinetics; Lysophosphatidylcholines; Mice; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium.
Topics: Aequorin; Affinity Labels; Alkaloids; Arachidonic Acid; Calcimycin; Calcium; Cations, Divalent; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Inositol Phosphates; Luminescent Measurements; Protein Kinase C; Radioimmunoassay; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation.
Topics: Alkaloids; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Cations, Divalent; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ionomycin; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Involvement of protein kinase C in thrombin-induced translocation of Gi2 alpha from the membrane to the cytosol in mouse mastocytoma P-815 cells.
Topics: Adenosine Diphosphate Ribose; Alkaloids; Animals; Biological Transport; Cell Membrane; Cytosol; Enzyme Activation; GTP-Binding Proteins; In Vitro Techniques; Ionomycin; Mast Cells; Mice; Pertussis Toxin; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Staurosporine, a potent protein kinase C inhibitor, augments phorbol ester-caused ornithine decarboxylase induction in mouse epidermis.
Topics: Administration, Topical; Alkaloids; Animals; Dinoprostone; Drug Synergism; Enzyme Induction; Epidermis; Female; Indomethacin; Mice; Ornithine Decarboxylase; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
The role of protein kinase-C in control of aldosterone production by rat adrenal glomerulosa cells: activation of protein kinase-C by stimulation with potassium.
Topics: Aldosterone; Alkaloids; Angiotensin II; Animals; Calcium; Cells, Cultured; Enzyme Activation; Male; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1992 |
Control of thyroid secretion: effects of stimulators of protein kinase C, thyrotropin, and calcium mobilization on secretion of iodinated compounds from sheep thyroid cells.
Topics: Alkaloids; Animals; Calcimycin; Calcium; Cells, Cultured; Inositol Phosphates; Iodine Radioisotopes; Protein Kinase C; Protein Kinases; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Thyroglobulin; Thyroid Gland; Thyroid Hormones; Thyrotropin | 1992 |
Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors.
Topics: Alkaloids; Cell Differentiation; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Humans; Neuroblastoma; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.
Topics: 3T3 Cells; Alkaloids; Animals; Autoradiography; Down-Regulation; Epidermal Growth Factor; Insulin; Mice; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Role of protein phosphorylation in activation of interferon-stimulated gene factors.
Topics: 2-Aminopurine; Alkaloids; Base Sequence; Cell Nucleus; Cycloheximide; DNA-Binding Proteins; HeLa Cells; Humans; Interferon-alpha; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, alpha Subunit; Interferon-Stimulated Gene Factor 3, gamma Subunit; Macromolecular Substances; Models, Biological; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1992 |
Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Interleukin-1; Interleukin-2; Interleukin-4; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured | 1992 |
Modulation by staurosporine of phorbol-ester-induced effects on growth and protein kinase C localization in A549 human lung-carcinoma cells.
Topics: Alkaloids; Bryostatins; Cell Division; DNA; Down-Regulation; Enzyme Activation; Humans; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Nuclear protein kinase C activity is decreased in Friend erythroleukemia cells induced to differentiate.
Topics: Acetamides; Alkaloids; Cell Division; Cell Nucleus; Cell Transformation, Viral; Dimethyl Sulfoxide; DNA; Friend murine leukemia virus; Hematinics; Humans; Leukemia, Erythroblastic, Acute; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine; Tritium; Tumor Cells, Cultured | 1992 |
The rat lacrimal gland expresses the alpha isoform of PKC. Further evidence for the PMA-activated and phospholipid-independent protein kinase activity.
Topics: Alkaloids; Animals; Arachidonic Acids; Chromatography, DEAE-Cellulose; Enzyme Activation; Lacrimal Apparatus; Male; Phospholipids; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Effect of phorbol myristate acetate on release of arachidonic acid and its metabolites in the osteoblastic MOB 3-4 cell line and its subclone, MOB 3-4-F2.
Topics: Alkaloids; Animals; Animals, Newborn; Arachidonic Acids; Cell Line; Clone Cells; DNA; Egtazic Acid; Kinetics; Mice; Osteoblasts; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Granulocyte-macrophage colony-stimulating factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins.
Topics: Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Phosphorylation of the inhibitory guanine-nucleotide-binding protein as a possible mechanism of inhibition by protein kinase C of agonist-induced Ca2+ mobilization in human platelet.
Topics: Alkaloids; Amino Acid Sequence; Arginine Vasopressin; Blood Platelets; Blotting, Western; Calcium; Enzyme Activation; GTP-Binding Proteins; Humans; Molecular Sequence Data; Phosphorylation; Platelet Activating Factor; Precipitin Tests; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Development and characterization of a protein kinase C beta-isozyme-deficient T-cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Flow Cytometry; Humans; Interleukin-2; Isoenzymes; Isoquinolines; Phenotype; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1992 |
K562 leukemia cells express P2T (adenosine diphosphate) purinergic receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkaloids; Calcium; Fura-2; Leukemia; Protein Kinase C; Receptors, Purinergic; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells.
Topics: Adhesins, Bacterial; Alkaloids; Bacterial Proteins; Epithelium; HeLa Cells; Humans; Protein Kinase C; Protein-Tyrosine Kinases; Salmonella typhimurium; Staurosporine; Tetradecanoylphorbol Acetate; Yersinia | 1992 |
Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells.
Topics: Adenosine Triphosphate; Alkaloids; Bacterial Proteins; Cell Line; Cell Membrane Permeability; Drug Synergism; Enzyme Activation; Glycerophospholipids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Neomycin; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Staurosporine; Streptolysins; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.
Topics: Alkaloids; Animals; Base Sequence; Calcium; DNA Probes; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Mice; Molecular Sequence Data; Polychlorinated Dibenzodioxins; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Disruption of endothelial actin microfilaments by protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cell Count; Cells, Cultured; Endothelium, Vascular; Image Processing, Computer-Assisted; Isoquinolines; Phalloidine; Piperazines; Protein Kinase C; Rhodamines; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1992 |
Intracellular Ca2+ mobilization and not calcium influx promotes phorbol ester-stimulated thromboxane A2 synthesis in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Chromatography, High Pressure Liquid; Cytosol; Drug Synergism; Humans; Membrane Lipids; Phorbol 12,13-Dibutyrate; Phospholipids; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1992 |
Haematopoietic stem cell lines activate novel enhancer-dependent expression of reporter DNA immediately after transfection by mechanisms involving interleukin 3 and protein kinase C.
Topics: Alkaloids; Animals; Cell Line; Enhancer Elements, Genetic; Gene Expression Regulation; Genes, fos; Genes, jun; Hematopoietic Stem Cells; In Vitro Techniques; Interleukin-3; Mice; Protein Kinase C; Regulatory Sequences, Nucleic Acid; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1992 |
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Regulation of inhibin beta B-subunit mRNA expression in rat Sertoli cells: consequences for the production of bioactive and immunoreactive inhibin.
Topics: Alkaloids; Animals; Calcimycin; Calcium; Cells, Cultured; Centrifugation, Density Gradient; Inhibins; Male; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Sertoli Cells; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Regulation of inositol transport by glucose and protein kinase C in mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport, Active; Cells, Cultured; Glomerular Mesangium; Glucose; Hyperglycemia; Inositol; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition.
Topics: Alkaloids; Animals; Binding, Competitive; Cell Division; Down-Regulation; Kinetics; Microscopy, Electron, Scanning; Nerve Growth Factors; Neurites; PC12 Cells; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C does not participate in carbachol's secretory action in T84 cells.
Topics: Alkaloids; Calcium; Carbachol; Cell Line; Colon; Diglycerides; Drug Interactions; Drug Synergism; Enzyme Activation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C.
Topics: Alkaloids; Animals; Autoradiography; Blotting, Western; Brain; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Phosphorylation; Protein Kinase C; Rats; Recombinant Proteins; RNA Splicing; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C zeta and eta in murine epidermis. TPA induces down-regulation of PKC eta but not PKC zeta.
Topics: Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Cytosol; Down-Regulation; Epidermis; Female; Immunoblotting; Indole Alkaloids; Isoenzymes; Mice; Molecular Sequence Data; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
The activation of the electrogenic NADPH oxidase.
Topics: Alkaloids; Cell Membrane; Enzyme Activation; Humans; Membrane Potentials; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Interactions between calcium and protein kinase C in the control of signaling and secretion in pituitary gonadotrophs.
Topics: Alkaloids; Animals; Biological Transport; Blotting, Western; Calcium; Calcium Channels; Cells, Cultured; Enzyme Activation; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Membrane Potentials; Pituitary Gland, Anterior; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Signal Transduction; Staurosporine; Temperature; Tetradecanoylphorbol Acetate | 1991 |
Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.
Topics: Alkaloids; Animals; Cartilage, Articular; Cells, Cultured; Dinoprostone; Enzyme Activation; Fibroblast Growth Factor 2; Gelatinases; Interleukin-1; Isoenzymes; Kinetics; Pepsin A; Phosphoproteins; Phosphorylation; Protein Kinase C; Rabbits; Recombinant Proteins; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Epidermis; Epinephrine; Histamine; Isoquinolines; Pertussis Toxin; Piperazines; Receptors, Adrenergic, beta; Receptors, Histamine; Skin; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Mechanisms controlling the level of receptors for tumor necrosis factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Enzyme Activation; Fibroblasts; HeLa Cells; Humans; Interleukin-1; Lymphoma, Large B-Cell, Diffuse; Protein Kinase C; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
The Na+/H+ exchanger is phosphorylated in human platelets in response to activating agents.
Topics: Alkaloids; Blood Platelets; Carrier Proteins; Diglycerides; Ethers, Cyclic; Humans; Hydrogen-Ion Concentration; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Barbiturates enhance retinoic acid or 1,25-dihydroxyvitamin D3-induced differentiation of leukemia HL-60 cells.
Topics: Alkaloids; Barbiturates; Bucladesine; Calcitriol; Cell Differentiation; Cell Line; Dactinomycin; Dimethyl Sulfoxide; Granulocytes; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Macrophages; Monocytes; Pentobarbital; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1991 |
Topological regulation of cell-membrane phosphoinositidase C.
Topics: Alkaloids; Cell Line; Cell Membrane; Cytochalasin B; Flow Cytometry; Humans; Kinetics; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release.
Topics: Adenosine Triphosphate; Adenylate Cyclase Toxin; Alkaloids; Animals; Arachidonic Acids; Carbachol; Cell Line; Cyclic AMP; GTP-Binding Proteins; Pertussis Toxin; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Purinergic; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 1991 |
Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; CD4 Antigens; Cyclic AMP; Down-Regulation; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1991 |
Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Antibodies, Monoclonal; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line; Cell Movement; Cytokines; DNA Replication; Drug Synergism; Female; Floxuridine; Growth Substances; Humans; Interleukin-6; Methotrexate; Protein Kinase C; Recombinant Proteins; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils.
Topics: Alkaloids; Calcium; Cell Membrane; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Modulation of Na+/H+ exchange and intracellular pH by protein kinase C and protein phosphatase in blood platelets.
Topics: Alkaloids; Blood Platelets; Carrier Proteins; Cytoplasm; Diglycerides; Ethers, Cyclic; Fluoresceins; Humans; Hydrogen-Ion Concentration; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Phorbol ester-mediated inhibition of IFN-alpha/beta gene transcription in blood mononuclear leukocytes.
Topics: Alkaloids; Blotting, Northern; Cells, Cultured; Cycloheximide; Diglycerides; Gene Expression; Herpes Simplex; Humans; In Vitro Techniques; Interferon-alpha; Interferon-beta; Leukocytes, Mononuclear; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Protein Kinase C; RNA, Messenger; Simplexvirus; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Activation of protein kinase-C inhibits vitamin D receptor gene expression.
Topics: Alkaloids; Animals; Blotting, Northern; Blotting, Southern; Calcimycin; Cell Division; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Fibroblast Growth Factor 2; Gene Expression Regulation, Enzymologic; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Receptors, Calcitriol; Receptors, Steroid; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-alpha isoenzyme in hepatoma cells.
Topics: Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoenzymes; Kinetics; Liver Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Desensitization of endogenous angiotensin II receptors in Xenopus oocytes: a role of protein kinase C.
Topics: Acetylcholine; Alkaloids; Angiotensin II; Animals; Binding Sites; Bucladesine; Dose-Response Relationship, Drug; Electric Conductivity; Hydrolysis; Microbial Collagenase; Oocytes; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Receptors, Angiotensin; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis | 1991 |
Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Cells, Cultured; Glucose; Hypoglycemia; Insulin; Insulin Resistance; Isoquinolines; Male; Phosphorylation; Piperazines; Polymyxin B; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.
Topics: Alkaloids; Animals; Cell Line; Chromosome Deletion; Glucose; Glycogen; Humans; Insulin; Kinetics; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Sp1 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca(2+)-calmodulin-dependent pathway in isolated rat pancreatic acini. A possible mechanism for diacylglycerol accumulation.
Topics: Alkaloids; Animals; Bombesin; Bucladesine; Calcimycin; Calcium; Calmodulin; Carbachol; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Diglycerides; In Vitro Techniques; Kinetics; Male; Nucleotidyltransferases; Pancreas; Phosphatidylcholines; Protein Kinase C; Rats; Rats, Inbred Strains; Secretin; Sincalide; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Regulation of plasma membrane permeability to calcium in primary cultures of rat hepatocytes.
Topics: Alkaloids; Animals; Biological Transport; Calcium; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Endoplasmic Reticulum; Liver; Male; Phosphotransferases; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Receptors, Vasopressin; Spectrophotometry; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
Topics: Alkaloids; Amsacrine; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Etoposide; Humans; Leukemia; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1991 |
Effects of protein kinase A and calcium/phospholipid-dependent kinase modulators in the process of HL-60 cell differentiation: their opposite effects between HL-60 cell and K-562 cell differentiation.
Topics: Alkaloids; Calcium; Cell Differentiation; Cell Line; Cholecalciferol; Diglycerides; Enzyme Activation; Gene Expression Regulation; Isoquinolines; Leukemia, Promyelocytic, Acute; Magnesium; Muramidase; Phenotype; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Feedback; Ionomycin; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Membrane Glycoproteins; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Higher Na(+)-H+ exchange rate and more alkaline intracellular pH set-point in essential hypertension: effects of protein kinase modulation in platelets.
Topics: Alkaloids; Blood Platelets; Carrier Proteins; Humans; Hydrogen-Ion Concentration; Hypertension; Male; Middle Aged; Phosphorylation; Protein Kinase C; Protein Kinases; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism.
Topics: Alkaloids; Animals; Arachidonic Acids; Basal Metabolism; Calcimycin; Cells, Cultured; Enzyme Activation; Female; Leukotriene B4; Macrophages, Alveolar; Peritoneum; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Effect of recombinant human granulocyte/macrophage colony-stimulating factor on neutrophil superoxide production.
Topics: Adult; Alkaloids; Cytochalasin B; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Rolipram; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Oscillatory muscarinic acetylcholine responses of Xenopus oocytes are desensitized by protein kinase C and sensitized by protein phosphatase 2B.
Topics: Acetylcholine; Alkaloids; Animals; Calcineurin; Calcium; Calmodulin; Calmodulin-Binding Proteins; Cell Membrane; Cells, Cultured; Cytosol; Electrophysiology; Feedback; Female; Inositol Phosphates; Oocytes; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine; Xenopus laevis | 1991 |
Inhibition of protein kinase C activity in cultured pituitary cells attenuates both cyclic AMP-independent and -dependent secretion of ACTH.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Alkaloids; Animals; Arginine Vasopressin; Carcinogens; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Kinetics; Male; Phorbol Esters; Pituitary Gland, Anterior; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Veratridine | 1991 |
Acute alpha 1-adrenergic stimulation of cardiac protein synthesis may involve increased intracellular pH and protein kinase activity.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Epinephrine; Hydrogen-Ion Concentration; Hydrolysis; Insulin; Myocardium; Prazosin; Propranolol; Protein Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Yohimbine | 1991 |
Staurosporine inhibits neutrophil phagocytosis but not iC3b binding mediated by CR3 (CD11b/CD18).
Topics: Alkaloids; CD18 Antigens; Complement C3b; Dose-Response Relationship, Drug; Glucans; Humans; Macrophage-1 Antigen; Neutrophils; Phagocytosis; Phosphorylation; Protein Kinase C; Receptors, Fc; Receptors, Leukocyte-Adhesion; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro.
Topics: Alkaloids; Animals; Carcinogenicity Tests; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Induction; Epidermal Growth Factor; Keratinocytes; Mice; Mice, Inbred BALB C; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate; Transglutaminases; Tumor Cells, Cultured | 1991 |
Phorbol esters and cyclic AMP activate AMP deaminase in adult rat cardiac myocytes.
Topics: Adrenergic alpha-Agonists; Alkaloids; AMP Deaminase; Animals; Cyclic AMP; Enzyme Activation; Epinephrine; Inosine Monophosphate; Kinetics; Myocardium; Phenylephrine; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Amylase release from streptolysin O-permeabilized pancreatic acini.
Topics: Alkaloids; Amylases; Animals; Bacterial Proteins; Calcium; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Male; Mice; Pancreas; Protein Kinase C; Staurosporine; Streptolysins; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Survival; Histamine Release; Immunoglobulin E; Isoquinolines; Leukotrienes; Mast Cells; Piperazines; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Basophils; Calcium; Cell Degranulation; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptor Aggregation; Signal Transduction; Sphingosine; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cholecystokinin; In Vitro Techniques; Isoquinolines; Pancreas; Piperazines; Protein Kinase C; Rabbits; Secretory Rate; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Evidence that Ca2(+)-dependent activation of airway epithelia Cl- channels is not dependent on phosphorylation.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Cells, Cultured; Chloride Channels; Cyclic AMP; Cytosol; Dogs; Epithelium; Iodides; Ion Channels; Kinetics; Membrane Proteins; Muscle, Smooth; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1990 |
A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.
Topics: Adrenal Gland Neoplasms; Alkaloids; Bradykinin; Gene Expression Regulation; Humans; Nerve Growth Factors; Neurotensin; Peptide Fragments; Pheochromocytoma; Protein Kinase C; RNA; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Effects of H7 and staurosporine on cytosolic free calcium and amylase secretion in rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Carbachol; Cytosol; Isoquinolines; Kinetics; Male; Pancreas; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.
Topics: Acute Disease; Alkaloids; Down-Regulation; Granulocyte Colony-Stimulating Factor; Granulocytes; Humans; In Vitro Techniques; Leukemia, Myeloid; Protease Inhibitors; Receptors, Granulocyte Colony-Stimulating Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1991 |
Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Cell Compartmentation; E-Selectin; Endothelium, Vascular; Enzyme Activation; Histocompatibility Antigens Class I; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Phosphoproteins; Piperazines; Protein Biosynthesis; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcimycin; Carbachol; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzymes; Isoquinolines; Lipase; Nucleic Acid Hybridization; Pancreas; Pancreatic Elastase; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Differential activation of human basophils by anti-IgE and formyl-methionyl-leucyl-phenylalanine. Indications for protein kinase C-dependent and -independent activation pathways.
Topics: Alkaloids; Androstadienes; Antibodies, Anti-Idiotypic; Basophils; Cells, Cultured; Histamine Release; Humans; Immunoglobulin E; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated.
Topics: Alkaloids; Animals; Bucladesine; Cell Adhesion Molecules; Cell Line, Transformed; Chlorocebus aethiops; DNA; Epitopes; Fibroblasts; Integrins; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Membrane Proteins; Protein Kinase C; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Activation of signal transduction pathways protects quiescent Balb/c-3T3 fibroblasts against death due to serum deprivation.
Topics: 2-Aminopurine; Alkaloids; Animals; Cell Division; Cell Survival; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred BALB C; Neutral Red; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; RNA; S Phase; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
The ability of staurosporine to modulate pancreatic acinar cell desensitization by TPA, carbamylcholine and caerulein.
Topics: Alkaloids; Amylases; Animals; Carbachol; Ceruletide; Dose-Response Relationship, Drug; Enzyme Activation; Male; Pancreas; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Second messenger pathways mediating chicken luteinizing hormone secretion from dispersed pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Chickens; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Pituitary Gland; Protein Kinase C; Second Messenger Systems; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transforming Growth Factor alpha | 1991 |
Regulation of Na(+)-Ca2+ exchange in cultured human mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Calcium; Cell Line; Culture Media; Endothelins; Fura-2; Glomerular Mesangium; Gramicidin; Homeostasis; Humans; Insulin; Ionophores; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Sodium; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1991 |
Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Calcimycin; Dose-Response Relationship, Drug; Histamine Release; Humans; Immunoglobulin E; Lung; Mast Cells; Protein Kinase C; Signal Transduction; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Hepatocanalicular organic-anion transport is regulated by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Anion Transport Proteins; Anions; Bile Canaliculi; Biological Transport; Bucladesine; Carrier Proteins; Colforsin; Cyclic AMP; Glucagon; Glutathione; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1991 |
Regulation by forskolin of cyclic AMP phosphodiesterase and protein kinase C activity in LLC-PK1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cells, Cultured; Colforsin; Cyclic GMP; Galactose; Macaca mulatta; Pregnenolone; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.
Topics: Alkaloids; Cell Membrane; Diglycerides; Diterpenes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Neutrophils; Potassium; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Valinomycin | 1991 |
Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Astrocytoma; Dactinomycin; Glial Fibrillary Acidic Protein; Humans; Isoquinolines; Piperazines; Protein Kinase C; RNA; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa | 1991 |
Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Concanavalin A; Cross-Linking Reagents; Diterpenes; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Isoquinolines; Kinetics; Lymphocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Phytohemagglutinins; Piperazines; Precipitin Tests; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester-induced down-regulation of the 80-kDa myristoylated alanine-rich C-kinase substrate-related protein in Swiss 3T3 fibroblasts. Inhibition by staurosporine.
Topics: 3T3 Cells; Alkaloids; Animals; Blotting, Western; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinases negatively affect nuclear factor-kappa B activation by tumor necrosis factor-alpha at two different stages in promyelocytic HL60 cells.
Topics: Alkaloids; Blotting, Northern; Cell Line; Cell Nucleus; Cytosol; Humans; Interleukin-1; Kinetics; Leukemia, Promyelocytic, Acute; Macromolecular Substances; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1992 |
Regulation of prostaglandin H synthase activity in dog urothelial cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dinoprostone; Dogs; Prostaglandin-Endoperoxide Synthases; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Line; Chlorides; Colon; Humans; Intestinal Mucosa; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase Inhibitors; Rubidium; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Role of protein kinase C in the acrosome reaction of mammalian spermatozoa.
Topics: Acrosome; Alkaloids; Animals; Cattle; Immunohistochemistry; In Vitro Techniques; Male; Protein Kinase C; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Role of [Ca2+]i in induction of c-fos, c-jun, and c-myc mRNA in rat PTE after oxidative stress.
Topics: Alkaloids; Animals; Benzamides; Blotting, Northern; Calcium; Catalase; Cell Hypoxia; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, fos; Genes, jun; Genes, myc; In Vitro Techniques; Ionomycin; Kidney Tubules; Male; Protein Kinase C; Rats; Rats, Inbred F344; RNA, Messenger; Staurosporine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Xanthine; Xanthines | 1992 |
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.
Topics: Alkaloids; Amino Acid Sequence; Cell Line; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Humans; Kidney; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Protein Kinase C; Sequence Alignment; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin | 1992 |
Protein kinase C promotes arachidonate mobilization through enhancement of CoA-independent transacylase activity in platelets.
Topics: Acyl Coenzyme A; Acyltransferases; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Coenzyme A; Diglycerides; Kinetics; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Diterpenes; Fibroblasts; Humans; Interleukin-1; Isoquinolines; Lyngbya Toxins; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cell Line; Enzyme Activation; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Isoquinolines; Kinetics; Leukemia, Myeloid; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; RNA, Messenger; RNA, Neoplasm; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase activity required for an early step in interferon-alpha signaling.
Topics: Alkaloids; Carbazoles; DNA-Binding Proteins; HeLa Cells; Humans; Indole Alkaloids; Interferon-alpha; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, alpha Subunit; Interferon-Stimulated Gene Factor 3, gamma Subunit; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1991 |
Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
Topics: Alkaloids; Animals; Aorta; Arachidonic Acid; Bradykinin; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Lysophospholipids; Protein Kinase C; Sodium Fluoride; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1991 |
Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro.
Topics: Alkaloids; Animals; Brain Neoplasms; Cell Division; DNA, Neoplasm; Glioma; Humans; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
A role for protein kinases in the growth hormone regulation of cytochrome P4502C12 and insulin-like growth factor-I messenger RNA expression in primary adult rat hepatocytes.
Topics: Alkaloids; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Diglycerides; Down-Regulation; Enzyme Activation; Gene Expression Regulation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Liver; Male; Protein Kinase C; Rats; Rats, Inbred Strains; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Signal transduction in endotoxin-stimulated synthesis of TNF-alpha and prostaglandin E2 by rat Kupffer cells. Role of extracellular calcium ions and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Dinoprostone; Egtazic Acid; Endotoxins; Interferon-gamma; Isoquinolines; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; Salmonella; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1991 |
dsDNA-stimulated phosphorylation of a 72-kDa nucleoprotein accompanies PMA-induced HL-60 leukemic cell differentiation.
Topics: Alkaloids; Cell Differentiation; Deoxyribonucleases; DNA; Humans; Leukemia; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein Kinases; Ribonucleases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Basic fibroblast growth factor stimulates glomerular mesangial cell proliferation through a protein kinase C-independent pathway.
Topics: Alkaloids; Animals; Cell Division; Cells, Cultured; Enzyme Activation; Fibroblast Growth Factor 2; Glomerular Mesangium; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Effects of a phorbol ester and staurosporine on electro- and pharmacomechanical coupling in a resistance artery.
Topics: Alkaloids; Animals; Calcium; Calcium Channel Blockers; Electrophysiology; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Protein Kinase C; Rats; Rats, Inbred WKY; Staurosporine; Stimulation, Chemical; Sympathectomy, Chemical; Tetradecanoylphorbol Acetate; Vascular Resistance | 1991 |
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Membrane; Clone Cells; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Isoquinolines; Leukemia, Myeloid; Lipid Metabolism; Piperazines; Protein Kinase C; Staurosporine; Streptolysins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
Protein kinase C activation and protooncogene expression in differentiation/retrodifferentiation of human U-937 leukemia cells.
Topics: Alkaloids; Biomarkers, Tumor; Cell Differentiation; Cytokines; Enzyme Activation; Gene Expression Regulation, Leukemic; Humans; Lymphoma, Large B-Cell, Diffuse; Monocytes; Neoplasm Proteins; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; RNA, Neoplasm; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Phorbol ester stimulates PAF synthesis via the activation of protein kinase C in rat leukocytes.
Topics: Acetyltransferases; Alkaloids; Animals; Enzyme Activation; In Vitro Techniques; Kinetics; Leukocytes; Male; Microsomes; Platelet Activating Factor; Platelet Aggregation; Protein Kinase C; Rabbits; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C activity and multidrug resistance in MOLT-3 human lymphoblastic leukemia cells resistant to trimetrexate.
Topics: Alkaloids; Cell Division; Drug Resistance; Humans; In Vitro Techniques; Leukemia, Lymphoid; Protein Kinase C; Quinazolines; Staurosporine; Tetradecanoylphorbol Acetate; Trimetrexate; Tumor Cells, Cultured | 1991 |
Prostacyclin secretion and specific intracellular protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Heat-Shock Proteins; Hot Temperature; Isoquinolines; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Secretory Rate; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1991 |
Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C.
Topics: Actins; Alkaloids; Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Calcium; Carbazoles; Cell Line; Diglycerides; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macromolecular Substances; Protein Kinase C; Rats; Receptors, Fc; Receptors, IgE; Serotonin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: evidence for a protein kinase C-independent staurosporine-sensitive step.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Clone Cells; Fluorescence; H-2 Antigens; Iodine Radioisotopes; Lymphocyte Activation; Mice; Phosphorylation; Protein Kinase C; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1991 |
GM-CSF and phorbol esters modulate GM-CSF receptor expression by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Down-Regulation; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Staurosporine, a protein kinase C inhibitor, inhibits atrial natriuretic peptide secretion induced by sarafotoxin, endothelin and phorbol ester.
Topics: Alkaloids; Animals; Atrial Natriuretic Factor; Blood Pressure; Endothelins; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Myocardial Contraction; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Viper Venoms | 1991 |
Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II).
Topics: Alkaloids; Animals; Antigens, CD; Antigens, Differentiation; Humans; In Vitro Techniques; Killer Cells, Natural; Metalloendopeptidases; Mice; Neutrophils; Phenanthrolines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Recombinant Proteins; Solubility; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells.
Topics: Acetylcholine; Alkaloids; Animals; Arachidonic Acid; Calcium; Diglycerides; Enzyme Activation; Feedback; Fura-2; In Vitro Techniques; Lacrimal Apparatus; Protein Kinase C; Rats; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
The response of 21-hydroxylase messenger ribonucleic acid levels to adenosine 3',5'-monophosphate and 12-O-tetradecanoylphorbol-13-acetate in bovine adrenocortical cells is dependent on culture conditions.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Alkaloids; Animals; Bucladesine; Cattle; Cells, Cultured; Culture Media; Culture Techniques; Cyclic AMP; Enzyme Induction; Kinetics; Male; Orchiectomy; Protein Kinase C; RNA, Messenger; Staurosporine; Steroid 21-Hydroxylase; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C is not involved in alpha 1-adrenoceptor-mediated positive inotropic effect.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electric Conductivity; Hydrolysis; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1991 |
Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.
Topics: Alkaloids; Cell Membrane; Cytoskeleton; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphorylation; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Endothelins activate Na+/H+ exchange in brain capillary endothelial cells via a high affinity endothelin-3 receptor that is not coupled to phospholipase C.
Topics: Alkaloids; Animals; Brain; Carrier Proteins; Electrophoresis, Gel, Two-Dimensional; Endothelins; Endothelium, Vascular; Phosphorylation; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Endothelin; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1991 |
Protein kinase C-dependent and -independent activation of the NADPH oxidase of human neutrophils.
Topics: Alkaloids; Aminoquinolines; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Recombinant Proteins; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Role of protein kinase C in catecholamine secretion from digitonin-permeabilized bovine adrenal medullary cells.
Topics: Adrenal Medulla; Alkaloids; Animals; Carbazoles; Catecholamines; Cattle; Cell Membrane Permeability; Cells, Cultured; Digitonin; Indole Alkaloids; Kinetics; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Carbachol-stimulated phosphorylation of a 170-kDa endogenous protein in avian salt gland cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Ducks; Ionomycin; Isoquinolines; Kinetics; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Proteins; Salt Gland; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
A continuous fluorescence assay for protein kinase C.
Topics: 2-Naphthylamine; Alkaloids; Amino Acid Sequence; Fluorescent Dyes; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Antigen-induced Fc receptor-dependent and -independent B cell desensitization. An elevation in [Ca2+]i is not sufficient and protein kinase C activation is not required for these pathways of surface IgM-mediated desensitization.
Topics: Alkaloids; Animals; Antigens; B-Lymphocytes; Calcium; Down-Regulation; Enzyme Activation; Immunoglobulin M; In Vitro Techniques; Lymphocyte Activation; Mice; Ovalbumin; Protein Kinase C; Receptors, Antigen, B-Cell; Receptors, Fc; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Division; Down-Regulation; ErbB Receptors; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Oncogenes; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
Topics: Adenosine Triphosphate; Adult; Alkaloids; Calcium; Cell Membrane; Cell-Free System; Cytosol; Enzyme Activation; Ethanol; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen-Ion Concentration; Kinetics; Magnesium; Neutrophils; Phosphatidic Acids; Phospholipase D; Proteins; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1991 |
Synthesis of intracellular histamine in platelets is associated with activation of protein kinase C, but not with mobilization of Ca2+.
Topics: Adenosine Diphosphate; Alkaloids; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Collagen; Cyclooxygenase Inhibitors; Enzyme Activation; Histamine; Humans; Phosphoproteins; Phosphorylation; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor.
Topics: Alkaloids; Base Sequence; Blotting, Northern; Blotting, Western; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Molecular Sequence Data; Plasmids; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Protein kinase C in tumoricidal activation of mouse macrophage cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cytotoxicity, Immunologic; Diglycerides; Enzyme Activation; Female; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Mast-Cell Sarcoma; Mice; Mice, Inbred BALB C; Phosphatidylserines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Blotting, Northern; Cell Differentiation; Cell Nucleus; DNA-Binding Proteins; Enzyme Activation; Enzyme Induction; Gene Expression Regulation; In Vitro Techniques; Intermediate Filament Proteins; Matrix Metalloproteinase 3; Metalloendopeptidases; Nerve Growth Factors; Neurofilament Proteins; Pheochromocytoma; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Contrasting effects of sn-1,2-dioctanoyl glycerol as compared to other protein kinase C activators in adrenal glomerulosa cells.
Topics: Aldosterone; Alkaloids; Angiotensin II; Animals; Biological Transport; Cattle; Cell Membrane Permeability; Diglycerides; Enzyme Activation; Potassium; Protein Kinase C; Rubidium; Staurosporine; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1991 |
Cholecystokinin-stimulated insulin secretion and protein kinase C in rat pancreatic islets.
Topics: Alkaloids; Animals; Cholecystokinin; Down-Regulation; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1991 |
Des-Arg9 bradykinin modulates DNA synthesis, phospholipase C, and protein kinase C in cultured mesangial cells. Distinction from effects of bradykinin.
Topics: Alkaloids; Animals; Bradykinin; Cell Division; Cells, Cultured; Diglycerides; DNA; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Glomerular Mesangium; In Vitro Techniques; Inositol Phosphates; Mitogens; Phosphoproteins; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1991 |
Stimulation of synthesis de novo of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human promyelocytic leukaemia (HL-60) cells by phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Dimethyl Sulfoxide; Dinoprostone; Enzyme Activation; Enzyme Induction; Humans; Hydroxyprostaglandin Dehydrogenases; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; NAD; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages.
Topics: Alkaloids; Animals; Cells, Cultured; Dinoprostone; Indoles; Kinetics; Macrophages; Maleimides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Effect of staurosporine on the induction of actin/gelsolin in PMA-treated HL-60 cells.
Topics: Actins; Alkaloids; Blotting, Western; Calcium-Binding Proteins; Cell Differentiation; Gelsolin; Humans; Macrophages; Microfilament Proteins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.
Topics: Alkaloids; Animals; CD4-Positive T-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; Gene Products, gag; HIV Core Protein p24; HIV-1; Lymphocyte Activation; Membrane Fusion; Protein Kinase C; Staurosporine; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate; Viral Core Proteins; Virus Replication | 1990 |
Transcriptional and post-transcriptional regulation of tyrosine hydroxylase gene by protein kinase C.
Topics: Alkaloids; Animals; Blotting, Northern; Cell Line; Dactinomycin; Gene Expression; Gene Expression Regulation, Enzymologic; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine 3-Monooxygenase | 1990 |
Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation.
Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; CD18 Antigens; Cell Aggregation; Cell Degranulation; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Vitro Techniques; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase C; Receptors, Leukocyte-Adhesion; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.
Topics: Alkaloids; Animals; Capillary Permeability; Diabetic Angiopathies; Diglycerides; Glucose; Glycerides; Granulation Tissue; Male; Microcirculation; NAD; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Ethers, Cyclic; Glycogen Synthase Kinase 3; Isoquinolines; Mice; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Phosphoproteins; Piperazines; Protein Kinase C; Protein Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.
Topics: Alkaloids; Animals; Carbazoles; Cell Line; Diglycerides; Fibroblasts; Indole Alkaloids; Inositol; Kinetics; Lysophosphatidylcholines; Myristic Acid; Myristic Acids; Phospholipase D; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Exocytosis in neurohypophysial nerve terminals is not coupled to protein kinase C translocation.
Topics: Alkaloids; Animals; Biological Transport; Cell Compartmentation; Cytosol; Electric Stimulation; Enzyme Activation; Exocytosis; Nerve Endings; Neurosecretory Systems; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1991 |
Antigen-induced phospholipase D activation in rat mast cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Helminth; Ascaris; Enzyme Activation; Enzyme Induction; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Mast Cells; Myristic Acid; Myristic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
WS-1 human fibroblasts contain distinct calcium and protein kinase C-mediated pathways for activation of Na+/H+ exchange: contrasting effects of thrombin and PMA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Biological Transport; Calcium; Cells, Cultured; DNA Replication; Enzyme Activation; Fibroblasts; Humans; Hydrogen; Hydrogen-Ion Concentration; Isoquinolines; Piperazines; Protein Kinase C; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na(+)-dependent uridine-transport system. Involvement of protein kinase C.
Topics: Alkaloids; Biological Transport; Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Protein Kinase C; Ribonucleosides; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Uridine | 1991 |
Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.
Topics: Alkaloids; Animals; Antigens; Arachidonic Acids; Calcimycin; Carbazoles; Cell Line; Cell Membrane; Cells, Cultured; Dexamethasone; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macrophages; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Serum Albumin, Bovine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
A rapid colorimetric microassay to detect agonists/antagonists of protein kinase C based on adherence of EL-4.IL-2 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carcinogens; Cell Adhesion; Colorimetry; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Isoquinolines; Lactams; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Reproducibility of Results; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover.
Topics: Alkaloids; Carbachol; Glycerophospholipids; Humans; Inositol Phosphates; Neuroblastoma; Phosphatidic Acids; Phospholipase D; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures.
Topics: Alkaloids; Animals; Axons; Cells, Cultured; Immunoglobulin G; Microscopy, Phase-Contrast; Nerve Degeneration; Nerve Growth Factors; Neurons; Protein Kinase C; Rats; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate | 1991 |
On the role of protein kinases in regulating neutrophil actin association with the cytoskeleton.
Topics: Actins; Alkaloids; Chemotactic Factors; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Humans; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Dual effect of protein kinase C on the induction of DNA synthesis by colcemid in G0-arrested human diploid fibroblasts.
Topics: Alkaloids; Blotting, Northern; Cell Line; Colchicine; Demecolcine; DNA; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Protein Kinase C; Resting Phase, Cell Cycle; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Phospholipid metabolism in bradykinin-stimulated human fibroblasts. I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C.
Topics: Alkaloids; Bradykinin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Diglycerides; Down-Regulation; Fibroblasts; Glyceryl Ethers; Humans; Phosphatidylcholines; Phosphatidylinositols; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.
Topics: Alkaloids; Calcium; Complement C5a; Eosinophils; Exocytosis; Humans; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Peroxidases; Pertussis Toxin; Platelet Activating Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Virulence Factors, Bordetella | 1991 |
Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells.
Topics: Alkaloids; Animals; Calcium; Cholecystokinin; Cytosol; In Vitro Techniques; Inositol Phosphates; Intercellular Signaling Peptides and Proteins; Kinetics; Male; Microscopy, Fluorescence; Pancreas; Peptides; Protein Kinase C; Rats; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Wasp Venoms | 1991 |
Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils.
Topics: Alkaloids; Complement C3b; Diglycerides; Humans; Immunoglobulin G; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phagocytosis; Phospholipase D; Phospholipids; Propranolol; Protein Kinase C; Saccharomyces cerevisiae; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Role of protein kinase C in adriamycin-induced erythroid differentiation of K562 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Division; Cell Line; Culture Techniques; Doxorubicin; Erythroid Precursor Cells; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Promotion of embryonic limb cartilage differentiation in vitro by staurosporine, a protein kinase C inhibitor.
Topics: Alkaloids; Animals; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; Collagen; Gene Expression; Glycosaminoglycans; Mesoderm; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Wings, Animal | 1991 |
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein.
Topics: Alkaloids; Animals; Cell Transformation, Viral; DNA; Gene Expression Regulation, Viral; Gene Products, tax; Hematopoietic Stem Cells; Human T-lymphotropic virus 1; Humans; Lipopolysaccharides; Mice; NF-kappa B; Protein Binding; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Mechanism of action of gonadotropin releasing hormone upon gonadotropin secretion: involvement of protein kinase C as revealed by staurosporine inhibition and enzyme depletion.
Topics: Alkaloids; Animals; Buserelin; Calcium; Cells, Cultured; Diglycerides; Female; Gonadotropin-Releasing Hormone; Ionomycin; Luteinizing Hormone; Phosphatidylserines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Platelet-derived growth factor stimulates non-mitochondrial Ca2+ uptake and inhibits mitogen-induced Ca2+ signaling in Swiss 3T3 fibroblasts.
Topics: Alkaloids; Animals; Biological Transport, Active; Bradykinin; Calcimycin; Calcium; Cells, Cultured; Dinoprostone; Fibroblasts; Ionomycin; Kinetics; Mice; Mitogens; Phospholipid Ethers; Platelet-Derived Growth Factor; Protein Kinase C; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1990 |
Inhibitory and stimulatory effects of phorbol ester on vasopressin-induced cellular responses in cultured rat aortic smooth muscle cells.
Topics: Alkaloids; Animals; Aorta; Arginine Vasopressin; Calcimycin; Calcium; Cells, Cultured; Cytosol; Drug Synergism; Enzyme Activation; Epoprostenol; Female; Inositol 1,4,5-Trisphosphate; Kinetics; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acids; Calcimycin; Cells, Cultured; Dinoprost; Dinoprostone; Endothelium, Vascular; Epoprostenol; Humans; Ionomycin; Isoquinolines; Phorbol Esters; Phospholipases A; Phospholipases A2; Piperazines; Platelet Activating Factor; Prostaglandin D2; Prostaglandins H; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Involvement of a guanine-nucleotide-binding protein-mediated mechanism in the enhancement of arachidonic acid liberation by phorbol 12-myristate 13-acetate and Ca2+ in saponin-permeabilized platelets.
Topics: Alkaloids; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cell Membrane Permeability; Chlorides; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pertussis Toxin; Protein Kinase C; Rabbits; Saponins; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Ca2(+)-independent stimulation of adenylate cyclase activity by muscarinic receptors in rat olfactory bulb.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Calcium; Calmodulin; Carbachol; Cell Membrane; Egtazic Acid; Male; Olfactory Bulb; Quinacrine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Contrasting effects of the protein kinase C inhibitor, staurosporine, on cytokine and phorbol ester stimulation of fructose 2,6-bisphosphate and prostaglandin E production by fibroblasts in vitro. Comparative studies using interleukin-1 alpha, tumour necr
Topics: Alkaloids; Biological Factors; Cells, Cultured; Cytokines; Fibroblasts; Fructosediphosphates; Hexosediphosphates; Humans; Interferon-gamma; Interleukin-1; Prostaglandins E; Protein Kinase C; Skin; Staurosporine; Stimulation, Chemical; Synovial Fluid; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Necrosis Factor-alpha | 1990 |
Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells. Characterization and induction by phorbol myristate acetate.
Topics: Alkaloids; Calcimycin; Carboxy-Lyases; Cycloheximide; Enzyme Induction; Histidine Decarboxylase; Humans; Leukemia, Basophilic, Acute; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Down-Regulation; GTP-Binding Proteins; Guinea Pigs; Isoquinolines; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Alveoli; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Sulfonylurea-stimulated glucose transport association with diacylglycerollike activation of protein kinase C in BC3H1 myocytes.
Topics: Alkaloids; Animals; Biological Transport; Cell Line; Cells, Cultured; Deoxyglucose; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glyburide; Insulin; Muscles; Protein Kinase C; Staurosporine; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Tolbutamide | 1990 |
Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cycloheximide; Dinoprostone; Dose-Response Relationship, Drug; Kinetics; Macrophages; Peritoneal Cavity; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Eicosanoids; Female; Hydrogen Peroxide; Macrophages; Phorbol Esters; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Signal transduction of a tissue interaction during embryonic heart development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Chick Embryo; Cholera Toxin; Endothelium; Enzyme Activation; Extracellular Matrix Proteins; Fetal Heart; Genistein; GTP-Binding Proteins; Isoflavones; Isoquinolines; Myocardium; Pertussis Toxin; Phenotype; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C.
Topics: Alkaloids; Aluminum; Aluminum Compounds; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Fluorides; Humans; Leukocytes, Mononuclear; Leukosialin; Phosphorylation; Protein Kinase C; Receptors, Antigen, T-Cell; Sialoglycoproteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor.
Topics: Alkaloids; Cell Differentiation; Cell Division; Gene Expression; Humans; Leukemia, Myeloid; Macrophages; Monocytes; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, Macrophage Colony-Stimulating Factor; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Biosynthesis of paf-acether. Activators of protein kinase C stimulate cultured mast cell acetyltransferase without stimulating paf-acether synthesis.
Topics: Acetyltransferases; Alkaloids; Animals; beta-N-Acetylhexosaminidases; Bone Marrow Cells; Calcium; Chlorpromazine; Chromatography, Gas; Cytoplasmic Granules; Enzyme Activation; Immunoglobulin E; Mast Cells; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Humans; In Vitro Techniques; Interferon-gamma; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinases; Receptors, Immunologic; Receptors, Interferon; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cells, Cultured; Chorionic Gonadotropin; Corticotropin-Releasing Hormone; Cyclic AMP; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Leydig Cells; Male; Protein Kinase C; Rats; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate | 1990 |
The antigonadotropic actions of prostaglandin F2 alpha and phorbol ester are mediated by separate processes in rat luteal cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Corpus Luteum; Cyclic AMP; Dinoprost; Drug Synergism; Female; Gonadotropins; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Effect of second-messenger modulators in K-562 cell differentiation: dual action of calcium/phospholipid-dependent protein kinase in the process of differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cell Differentiation; Cell Division; Cell Survival; Cytarabine; Diglycerides; Erythropoiesis; Globins; Hemin; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol.
Topics: Adipose Tissue; Alkaloids; Animals; Bucladesine; Dexamethasone; Drug Synergism; Enzyme Activation; Growth Hormone; Hypophysectomy; Isoproterenol; Lipolysis; Male; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Theophylline | 1990 |
Effect of staurosporine on the phorbol ester-induced activation of the Na+/H+ antiporter in smooth muscle cells.
Topics: Alkaloids; Animals; Aorta; Brain; Carrier Proteins; Cells, Cultured; Muscle, Smooth; Protein Kinase C; Rats; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Evidence for involvement of protein kinase C and cyclic adenosine 3',5' monophosphate-dependent protein kinase in the 1,25-dihydroxy-vitamin D3-mediated rapid stimulation of intestinal calcium transport, (transcaltachia).
Topics: Alkaloids; Animals; Biological Transport; Calcitriol; Calcium; Chickens; Colforsin; Cyclic AMP; Duodenum; Intestinal Mucosa; Intestines; Kinetics; Male; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Vitamin D Deficiency | 1990 |
Staurosporine enhances gonadotrophin-releasing hormone-stimulated luteinizing hormone secretion.
Topics: Alkaloids; Animals; Cells, Cultured; Cyclic AMP; Exocytosis; Inositol Phosphates; Luteinizing Hormone; Pituitary Gland, Anterior; Pituitary Hormone-Releasing Hormones; Protein Kinase Inhibitors; Sheep; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.
Topics: Alkaloids; Cells, Cultured; DNA Replication; Enzyme Activation; Glomerular Mesangium; Humans; Inositol Phosphates; Kinetics; Phosphatidic Acids; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1990 |
Effects of phorbol ester on cell growth inhibition by transforming growth factor beta 1 in human hepatoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Cell Division; DNA; Epithelial Cells; Growth Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Liver Neoplasms; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Enhancement of cyclic AMP metabolism in a B cell line by protein kinase C.
Topics: Alkaloids; Alprostadil; B-Lymphocytes; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Down-Regulation; Drug Synergism; Humans; Immunoglobulin M; In Vitro Techniques; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Mechanism and biological significance of the Ha-ras-induced activation of the Na+/H(+)-antiporter.
Topics: Alkaloids; Animals; Bombesin; Calcium; Carrier Proteins; Cell Line; Cytosol; Dexamethasone; Genes, ras; Hydrogen-Ion Concentration; Kinetics; Mammary Tumor Virus, Mouse; Mice; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1990 |
The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post-receptor mechanisms.
Topics: Alkaloids; Carbazoles; Dimethyl Sulfoxide; Humans; In Vitro Techniques; Indole Alkaloids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Two signal transduction pathways mediate interleukin-1 receptor expression in Balb/c3T3 fibroblasts.
Topics: Alkaloids; Animals; Cell Line; Colforsin; Cyclic AMP; Drug Synergism; Fibroblasts; Gene Expression; Interleukin-1; Mice; Mice, Inbred BALB C; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Receptors, Immunologic; Receptors, Interleukin-1; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Models, Chemical; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Activation of protein kinase C is not required for exocytosis from bovine adrenal chromaffin cells. The effects of protein kinase C(19-31), Ca/CaM kinase II(291-317), and staurosporine.
Topics: Adrenal Medulla; Alkaloids; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Enzyme Activation; Exocytosis; Kinetics; Molecular Sequence Data; Peptides; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Diacylglycerols and PMA are particularly effective stimulators of fluid pinocytosis in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Chemotaxis, Leukocyte; Colchicine; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Nocodazole; Oligopeptides; Pinocytosis; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Expression, purification, and characterization of protein kinase C-epsilon.
Topics: Alkaloids; Animals; Cell Line; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Diglycerides; DNA; Enzyme Activation; Insect Viruses; Insecta; Isoenzymes; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Plasmids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; DNA, Viral; Down-Regulation; Enhancer Elements, Genetic; Enzyme Activation; H-2 Antigens; HIV-1; Humans; Isoquinolines; Leukemia; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha | 1990 |
Fc receptor phosphorylation during receptor-mediated control of B-cell activation.
Topics: Alkaloids; Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line; Cell Membrane; Cricetinae; Cross-Linking Reagents; DNA; Dogs; Immunoglobulins; Immunosorbent Techniques; Lymphocyte Activation; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Receptors, Fc; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C.
Topics: Alkaloids; Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Dendrites; Enzyme Inhibitors; N-Methylaspartate; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
The effect of protein kinase-C inhibition on insulin receptor phosphorylation.
Topics: Alkaloids; Cell Line; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Insulin; Peptide Mapping; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase C; Receptor, Insulin; Staurosporine; Tetradecanoylphorbol Acetate; Trypsin | 1990 |
Insulin provokes apparent increases in rat adipocyte M-kinase.
Topics: Adipose Tissue; Alkaloids; Animals; Blotting, Western; Cytosol; Insulin; Molecular Weight; Peptide Fragments; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets.
Topics: Alkaloids; Animals; Calcium; Carbachol; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Molecular Weight; Phospholipids; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Further studies on the involvement of protein kinase C in human sperm flagellar motility.
Topics: Adult; Alkaloids; Diglycerides; Humans; Immunohistochemistry; Ionomycin; Male; Protein Kinase C; Sperm Motility; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Biological Transport; Cell Line; Cell Separation; Deoxyglucose; Hexoses; Insulin; Isoquinolines; Male; Muscles; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line).
Topics: 6-Ketoprostaglandin F1 alpha; Alkaloids; Animals; Calcimycin; Carbazoles; Cell Line; Drug Synergism; Epoprostenol; Indole Alkaloids; Liver; Platelet Activating Factor; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Evidence of a role for protein kinase C in epidermal growth factor-induced prostaglandin E2 synthesis in amnion cells.
Topics: Alkaloids; Amnion; Cell Line; Dinoprostone; Down-Regulation; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Pregnancy; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Enzyme Activation; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Dopamine induces neurite retraction in retinal horizontal cells via diacylglycerol and protein kinase C.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Alkaloids; Animals; Axons; Benzazepines; Catfishes; Cells, Cultured; Diglycerides; Dopamine; Ergolines; Haloperidol; Kainic Acid; Kinetics; Protein Kinase C; Quinpirole; Receptors, Dopamine; Retina; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Homologous desensitization of ATP-mediated elevations in cytoplasmic calcium and prostacyclin release in human endothelial cells does not involve protein kinase C.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Cells, Cultured; Cytoplasm; Endothelium, Vascular; Epoprostenol; Histamine; Humans; Kinetics; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Umbilical Veins | 1990 |
Role of protein kinase C in the regulation of cytosolic Ca2+ in A431 cells: separation of growth factor and bradykinin pathways.
Topics: Alkaloids; Bradykinin; Calcium; Cytosol; Down-Regulation; Epidermal Growth Factor; Humans; Ionomycin; Manganese; Protein Kinase C; Pyrimidinones; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1990 |
Involvement of protein kinase C in the mitogenic and chemotaxis effects of basic fibroblast growth factor on bovine cerebral cortex capillary endothelial cells.
Topics: Alkaloids; Animals; Capillaries; Cattle; Cell Division; Cells, Cultured; Cerebral Cortex; Chemotaxis; Endothelium, Vascular; Fibroblast Growth Factors; Kinetics; Mannosidases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Synergistic action of phorbol ester and IL-3 in the induction of "connective tissue-type" mast cell proliferation.
Topics: Alkaloids; Animals; Cell Division; Cells, Cultured; Connective Tissue Cells; Diglycerides; Drug Synergism; In Vitro Techniques; Interleukin-3; Interleukin-4; Mast Cells; Mice; Peritoneal Cavity; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by simultaneous activation of distinct signal transduction pathways.
Topics: Adenylyl Cyclases; Alkaloids; Colforsin; Humans; Interleukin-1; Killer Cells, Natural; Leukemia; Protein Kinase C; Receptors, Interleukin-2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Increased sensitivity to cis-diamminedichloroplatinum(II) in human ovarian carcinoma cells in response to treatment with 12-O-tetradecanoylphorbol 13-acetate.
Topics: Alkaloids; Cell Line; Cell Survival; Cisplatin; Female; Humans; Kinetics; Ovarian Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diglycerides; Drug Antagonism; Enzyme Activation; Glycerides; Isoquinolines; Methylcholanthrene; Mice; Palmitoylcarnitine; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Ca2(+)-induced secretion by electropermeabilized human neutrophils. The roles of Ca2+, nucleotides and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adult; Alkaloids; Calcium; Cell Membrane Permeability; Cytoplasmic Granules; Electric Stimulation; Glucuronidase; Humans; Isoquinolines; Kinetics; Lysosomes; Magnesium; Neutrophils; Piperazines; Proadifen; Protein Kinase C; Ribonucleotides; Staurosporine; Tetradecanoylphorbol Acetate; Transcobalamins | 1990 |
Identification of phosphoprotein NP33 as a nucleus-associated ribosomal S6 protein and its phosphorylation in hematopoietic cells.
Topics: Alkaloids; Amino Acid Sequence; Cell Line; Electrophoresis, Gel, Two-Dimensional; Hematopoietic Stem Cells; Humans; Molecular Sequence Data; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Ribosomal Protein S6; Ribosomal Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated wi
Topics: Alkaloids; Blood; Cell Division; Cell Line; Down-Regulation; Enzyme Activation; Growth Hormone; Humans; Kinetics; Lymphocytes; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, Somatotropin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Activation of protein kinase C inhibits extraction of serotonin by perfused rat lung in situ.
Topics: Alkaloids; Animals; Carcinogens; Diterpenes; Enzyme Activation; Kinetics; Lung; Male; Papaverine; Perfusion; Phorbol Esters; Protein Kinase C; Pulmonary Circulation; Rats; Rats, Inbred Strains; Serotonin; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1990 |
Calcium stimulates luteinizing-hormone (lutropin) exocytosis by a mechanism independent of protein kinase C.
Topics: Alkaloids; Animals; Barium; Calcium; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Exocytosis; Luteinizing Hormone; Pituitary Gland, Anterior; Protein Kinase C; Sheep; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Phosphatidylcholine hydrolysis stimulated by phorbol myristate acetate is mediated principally by phospholipase D in endothelial cells.
Topics: Alkaloids; Animals; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Ethanol; Hydrolysis; Kinetics; Phosphatidylcholines; Phospholipase D; Phospholipases; Pulmonary Artery; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors.
Topics: Alkaloids; Blood Platelets; Carbazoles; Diglycerides; Drug Synergism; Enzyme Activation; Feedback; Glycerides; Humans; Indole Alkaloids; Neomycin; Phosphatidic Acids; Phosphatidylcholines; Phosphorylation; Propranolol; Protein Kinase C; Second Messenger Systems; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Augmentation of cytotoxic effect of tumor necrosis factor on human immunodeficiency virus-infected cells by staurosporine, a potent protein kinase C inhibitor.
Topics: Alkaloids; Cell Line; Cell Survival; Cell Transformation, Viral; Drug Synergism; HIV; Humans; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1990 |
Diacylglycerol and protein kinase mediated noradrenergic responses in perfused rat kidneys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glomerular Filtration Rate; Gluconeogenesis; Glycerides; In Vitro Techniques; Isoquinolines; Kidney; Kidney Tubules; Male; Norepinephrine; Perfusion; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Renal Circulation; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Vascular Resistance | 1990 |
Role of protein kinase C in renal vasoconstriction caused by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil | 1990 |
Protein kinase C is present in human sperm: possible role in flagellar motility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibodies, Monoclonal; Humans; Immunohistochemistry; Isoquinolines; Kinetics; Male; Piperazines; Protein Kinase C; Reference Values; Sperm Motility; Spermatozoa; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: blockade by protein kinase inhibitors and relationship to tat-directed trans-activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Aminopurine; Adenine; Alkaloids; Cell Line; Clone Cells; Gene Products, tat; HIV-1; Humans; Idoxuridine; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Piperazines; Protein Kinase Inhibitors; Staurosporine; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Trans-Activators; Transcriptional Activation; Virus Replication | 1990 |
Phorbol-ester-induced down-regulation of protein kinase C in mouse pancreatic islets. Potentiation of phase 1 and inhibition of phase 2 of glucose-induced insulin secretion.
Topics: Alkaloids; Animals; Carbachol; Down-Regulation; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Protein kinase C potentiates stretch-induced cerebral artery tone by increasing intracellular sensitivity to Ca2+.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Basilar Artery; Calcium; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
Comparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; CD4 Antigens; Cell Line; Down-Regulation; Flow Cytometry; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Viral Core Proteins; Virus Replication | 1989 |
Effect of phorbol ester treatment on receptor-mediated versus G-protein-activator-mediated responses in platelets. Evidence for a two-site action of phorbol ester at the level of G-protein function.
Topics: Alkaloids; Blood Platelets; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Humans; In Vitro Techniques; Male; Phosphatidic Acids; Protein Kinase C; Serotonin; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors; Type C Phospholipases | 1989 |
Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Line; Erythrocytes; Granulocytes; Humans; Kinetics; Leukosialin; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphates; Phosphorylation; Phosphoserine; Protein Kinase C; Sialoglycoproteins; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Evidence for a protein kinase C-directed mechanism in the phorbol diester-induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine.
Topics: Alkaloids; Animals; Bucladesine; Cell Line; Choline; Colforsin; Diglycerides; Embryo, Mammalian; Fibroblasts; Glycerides; Glycerophospholipids; Hydrolysis; Myristic Acid; Myristic Acids; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Phospholipases; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide.
Topics: Alkaloids; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Chemotaxis; Kinetics; Lung Neoplasms; Mice; Mice, Inbred C57BL; Oligopeptides; Protein Kinase C; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Edema; Enzyme Induction; Female; Hyperplasia; Inflammation; Kinetics; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Protein Kinase C; Reference Values; Skin; Skin Neoplasms; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Ha-ras activates the Na+/H+ antiporter by a protein kinase C-independent mechanism.
Topics: Alkaloids; Amiloride; Bombesin; Carrier Proteins; Cells, Cultured; Fibroblasts; Genes, ras; Growth Substances; Hydrogen-Ion Concentration; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1989 |
Parathyroid hormone inhibition of Na+/phosphate cotransport in OK cells: requirement of protein kinase C-dependent pathway.
Topics: Alkaloids; Animals; Biological Transport; Carrier Proteins; Cell Line; Colforsin; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Kidney; Opossums; Parathyroid Hormone; Protein Kinase C; Sodium-Phosphate Cotransporter Proteins; Staurosporine; Symporters; Tetradecanoylphorbol Acetate | 1989 |
Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Isoquinolines; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Enhancement of adenosine A2 and prostaglandin E1 receptor-mediated cAMP generation by prior exposure of Swiss 3T3 fibroblasts to Ca2+-mobilizing receptor agonists or phorbol ester. Activation of protein kinase C triggers increases in the receptor density
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Alkaloids; Animals; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Diglycerides; Enzyme Activation; Fibroblasts; Isoquinolines; Kinetics; Mice; Piperazines; Prostaglandins E; Protein Kinase C; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Purinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics | 1989 |
Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.
Topics: Alkaloids; Animals; Antigens; Basophils; Calcimycin; Cell Line; Enzyme Activation; Kinetics; Leukemia; Phosphatidylinositols; Protein Kinase C; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Synergistic release of arachidonic acid from platelets by activators of protein kinase C and Ca2+ ionophores. Evidence for the role of protein phosphorylation in the activation of phospholipase A2 and independence from the Na+/H+ exchanger.
Topics: Adenosine Triphosphate; Alkaloids; Amiloride; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Carrier Proteins; Enzyme Activation; Humans; Indoles; Ionomycin; Ionophores; Kinetics; Lactams; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1989 |
1,2-dioctanoyl-sn-glycerol can stimulate neutrophils by different mechanisms. Evidence for a pathway that does not involve phosphorylation of the 47-kDa protein.
Topics: Alkaloids; Animals; Diglycerides; Diterpenes; Glycerides; Guinea Pigs; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Proteins; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Sodium-phosphate cotransport in OK cells: inhibition by PTH and "adaptation" to low phosphate.
Topics: Alkaloids; Animals; Bucladesine; Carrier Proteins; Cell Line; Colforsin; Kidney; Kinetics; Parathyroid Hormone; Peptide Fragments; Phosphates; Sodium-Phosphate Cotransporter Proteins; Staurosporine; Symporters; Teriparatide; Tetradecanoylphorbol Acetate | 1989 |
Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils.
Topics: Alkaloids; Aminoquinolines; Calcium; Complement C5a; Cytosol; Exocytosis; Fluorescent Dyes; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Diversity in the chemical nature and mechanism of response to tumor promoters.
Topics: Acrylamides; Alkaloids; Animals; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Cnidarian Venoms; Enzyme Induction; Ethers, Cyclic; Mice; Okadaic Acid; Ornithine Decarboxylase; Plant Extracts; Plants, Medicinal; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Vasoconstrictor Agents | 1989 |
Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells.
Topics: Alkaloids; Animals; Calcitonin; Cell Compartmentation; Cells, Cultured; Epithelium; Gene Expression Regulation; In Vitro Techniques; Kidney; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1989 |
Role of protein kinase C in U46619-induced platelet shape change, aggregation and secretion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Alkaloids; Animals; Blood Platelets; Calcium; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
A further comparison of insulin- and phorbol ester-stimulated glucose transport in adipocytes.
Topics: Adenosine Triphosphate; Adipose Tissue; Alkaloids; Animals; Arsenicals; Biological Transport, Active; Cell Fractionation; Cell Survival; Deoxyglucose; Glucose; In Vitro Techniques; Insulin; Kinetics; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.
Topics: Alkaloids; Animals; Carbazoles; Cell Compartmentation; Cell Membrane; Cytosol; Down-Regulation; Enzyme Activation; Glucose; In Vitro Techniques; Indole Alkaloids; Insulin; Insulin Secretion; Islets of Langerhans; Male; Protein Kinase C; Protein Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Stabilization of blood platelet microtubular system by staurosporine.
Topics: Alkaloids; Animals; Blood Platelets; In Vitro Techniques; Microscopy, Electron; Microtubules; Platelet Adhesiveness; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Modulation of endothelial cell expression of intercellular adhesion molecule 1 by protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, Surface; Carcinogens; Cell Adhesion; Cell Adhesion Molecules; Diterpenes; Endothelium, Vascular; Enzyme Activation; Humans; Isoquinolines; Kinetics; Membrane Glycoproteins; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Ribosomal protein S6 kinase and PKC in human mammary tumor cells.
Topics: Alkaloids; Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Growth Substances; Humans; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Alteration of intracellular actin levels induced by phorboldiester in human HL-60 leukemia cells susceptible or resistant to differentiation, and the effects of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Antibodies, Monoclonal; Antigen-Antibody Reactions; Cell Differentiation; Cell Line; Cytoplasm; Drug Resistance; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Macrophages; Neoplasm Proteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Staurosporine potentiates platelet activating factor stimulated phospholipase C activity in rabbit platelets but does not block desensitization by platelet activating factor.
Topics: Alkaloids; Animals; Blood Platelets; Drug Synergism; In Vitro Techniques; Inositol; Inositol Phosphates; Kinetics; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1989 |
Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion.
Topics: Alkaloids; Animals; Antilymphocyte Serum; Cell Line; Interleukin-1; Interleukin-2; Mice; Phorbol Esters; Phytohemagglutinins; Protein Kinase C; Sphingosine; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Calcitriol; Cell Differentiation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1988 |
Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells.
Topics: Alkaloids; Animals; Calcium; Cell Compartmentation; Enzyme Activation; Protein Kinase C; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate | 1988 |
Inhibition by cyclic AMP of phorbol ester-potentiated norepinephrine release from guinea pig brain cortical synaptosomes.
Topics: Alkaloids; Animals; Bucladesine; Carbazoles; Cerebral Cortex; Colforsin; Cyclic AMP; Enzyme Activation; Female; Guinea Pigs; Indoles; Male; Norepinephrine; Polymyxin B; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1988 |
Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Isoquinolines; Peptide PHI; Piperazines; Protein Kinase C; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Staurosporine; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1988 |
Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
Topics: Alkaloids; Benzofurans; Calcium; Cytosol; Diglycerides; Ethers; Fura-2; Homeostasis; Humans; In Vitro Techniques; Ionomycin; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1989 |
Staurosporine, a protein kinase C inhibitor, attenuates Ca2+-dependent stretch-induced vascular tone.
Topics: Alkaloids; Animals; Calcium; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Protein Kinase C; Rabbits; Reference Values; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation; Veins | 1989 |
A phorbol ester and a daphnane ester stimulate a calcium-independent kinase activity from human mononuclear cells.
Topics: Alkaloids; Antibodies, Monoclonal; Calcium; Chromatography; Diterpenes; Enzyme Activation; Freezing; Hot Temperature; Humans; Immunoblotting; Isoenzymes; Leukocytes, Mononuclear; Phosphatidylserines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Phorbol ester and A23187 have additive but mechanistically separate effects on vasopressin action in rabbit collecting tubule.
Topics: Alkaloids; Animals; Arginine Vasopressin; Calcimycin; Calcium; Enzyme Activation; Female; Indomethacin; Kidney Tubules; Kidney Tubules, Collecting; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Staurosporine; Temperature; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C.
Topics: Alkaloids; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Mice; Ornithine Decarboxylase; Protein Kinase C; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate | 1988 |
Phorbol 12-myristate 13-acetate inhibition of leukotriene D4-induced signal transduction was rapidly reversed by staurosporine.
Topics: Alkaloids; Calcium; Humans; In Vitro Techniques; Inositol Phosphates; Phosphatidylinositols; Protein Kinase C; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1988 |
Inhibition by staurosporine of mitogen-induced calcium mobilisation in human T lymphoblasts.
Topics: Alkaloids; Antibodies, Monoclonal; Calcium; Humans; In Vitro Techniques; Kinetics; Lymphocyte Activation; Mitogens; Protein Kinase C; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1988 |
Enhancement of the antiproliferative effect of cis-diamminedichloroplatinum(II) and nitrogen mustard by inhibitors of protein kinase C.
Topics: Alkaloids; Animals; Cell Division; Cisplatin; Drug Synergism; Mechlorethamine; Protein Kinase C; Quercetin; Rats; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1988 |
Calcium transients in human platelets monitored by aequorin, fura-2 and quin-2: effects of protein kinase C activation and inhibition.
Topics: Aequorin; Alkaloids; Aminoquinolines; Benzofurans; Blood Platelets; Calcium; Diglycerides; Enzyme Activation; Fluorescent Dyes; Fura-2; Humans; Kinetics; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1987 |
Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Enzyme Induction; Epidermis; In Vitro Techniques; Isoquinolines; Kinetics; Mice; Ornithine Decarboxylase; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1987 |
Effects of photodegradation products of nifedipine: the nitroso-derivative relaxes contractions of the rat aortic strip induced by norepinephrine and other agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta; Calcium Chloride; Dinoprost; Endothelins; Hemoglobins; Male; Methylene Blue; Nifedipine; Nitroso Compounds; Norepinephrine; Photochemistry; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Amylases; Animals; Calcium-Transporting ATPases; Cells, Cultured; Cholecystokinin; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Pancreas; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Sincalide; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors | 1995 |
EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line, Transformed; Cinnamates; Dinoprostone; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; Isoquinolines; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Decidua; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Interleukin-1; Isoquinolines; Piperazines; Pregnancy; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Thrombin induces GRO alpha/MGSA production in human umbilical vein endothelial cells.
Topics: Alkaloids; Amino Acid Sequence; Antithrombin III; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Growth Substances; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1; Molecular Sequence Data; Peptide Fragments; Protein Kinase C; Receptors, Thrombin; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1995 |
Potentiation of 5-HT3 receptor-mediated responses by protein kinase C activation.
Topics: Alkaloids; Animals; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; Female; Oocytes; Patch-Clamp Techniques; Protein Kinase C; Receptors, Serotonin; Serotonin Receptor Agonists; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis | 1995 |
Lysophosphatidylcholine inhibits relaxation of rabbit abdominal aorta mediated by endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor independent of protein kinase C activation.
Topics: Alkaloids; Animals; Aorta, Abdominal; Arginine; Biological Factors; Enzyme Activation; In Vitro Techniques; Lysophosphatidylcholines; Male; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation; Vasodilator Agents | 1995 |
The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Carrier Proteins; Cell Line; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Isoquinolines; Kidney; Kinetics; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Pharmacological investigations with different protein kinase C inhibitors on IgE-dependent and IgE-independent activation of human basophils.
Topics: Alkaloids; Basophils; Calcimycin; Exocytosis; Histamine; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptors, IgE; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.
Topics: Alkaloids; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; HeLa Cells; Hepatitis B virus; Humans; Isoquinolines; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenes; Oligodeoxyribonucleotides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Vaccinia virus; Viral Regulatory and Accessory Proteins | 1994 |
Stimulation of RNA synthesis in rat parotid lobules by phorbol myristate acetate.
Topics: Alkaloids; Animals; Calcimycin; Gene Expression Regulation; Parotid Gland; Protein Kinase C; Rats; RNA; Salivary Proteins and Peptides; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation | 1993 |
CD44 mediates hyaluronan binding by human myeloid KG1A and KG1 cells.
Topics: Alkaloids; Bone Marrow; Bone Marrow Cells; Carrier Proteins; Cell Adhesion; Cell Aggregation; Cell Line; Humans; Hyaluronan Receptors; Hyaluronic Acid; Receptors, Cell Surface; Receptors, Lymphocyte Homing; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Carbachol-induced potassium release in rat parotid acini: comparison of the roles of cytosolic Ca2+ and protein kinase C.
Topics: Alkaloids; Amylases; Animals; Calcium; Calcium Channel Blockers; Carbachol; Cytosol; Egtazic Acid; Enzyme Activation; Gallic Acid; Ionomycin; Male; Parotid Gland; Potassium; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1993 |
Endotoxin-induced tissue factor in human monocytes is dependent upon protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Endotoxins; Enzyme Activation; Gene Expression Regulation; Humans; Isoquinolines; Monocytes; Naphthalenes; Naphthol AS D Esterase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin | 1993 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Parallel regulation of parentally imprinted H19 and insulin-like growth factor-II genes in cultured human fetal adrenal cells.
Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Alkaloids; Blotting, Northern; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fetal Proteins; Gene Expression Regulation; Humans; In Situ Hybridization; Insulin-Like Growth Factor II; Interferon-gamma; Protein Kinase C; RNA; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Glycine; Intracellular Fluid; Kinetics; Magnesium Sulfate; N-Methylaspartate; Naphthalenes; Neurons; Pipecolic Acids; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Staurosporine, a non-specific PKC inhibitor, induces keratinocyte differentiation and raises intracellular calcium, but Ro31-8220, a specific inhibitor, does not.
Topics: Alkaloids; Calcium; Cell Differentiation; Cell Division; Humans; Indoles; Intracellular Membranes; Keratinocytes; Protein Kinase C; Protein Precursors; Staining and Labeling; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.
Topics: Acute-Phase Proteins; Alkaloids; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arachidonic Acid; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytosol; Humans; Leukotriene B4; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Control of lymphocyte integrin function: evidence for multiple contributing factors.
Topics: Alkaloids; Antibodies, Monoclonal; Antibody Specificity; Antigens, CD; Cell Adhesion; Collagen; Humans; Integrin alpha2; Integrin beta1; Integrins; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase.
Topics: Alkaloids; Amino Acid Oxidoreductases; Animals; Cattle; Cells, Cultured; Diglycerides; Endothelium, Vascular; Enzyme Activation; Nitric Oxide Synthase; Protein Kinase C; Pulmonary Artery; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzoquinones; Cell Cycle Proteins; Cell Line; Ceramides; Chlorocebus aethiops; Diglycerides; DNA Primers; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Kinetics; Lactams, Macrocyclic; Molecular Sequence Data; Muromonab-CD3; Mutagenesis, Site-Directed; Naphthalenes; Phorbol 12,13-Dibutyrate; Point Mutation; Polycyclic Compounds; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogene Proteins p21(ras); Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1994 |
Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells.
Topics: Alkaloids; Antigens, CD; CD11 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cells, Cultured; E-Selectin; Endothelium, Vascular; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1; Monocytes; Nicotiana; Nicotine; Plants, Toxic; Protein Kinase C; Smoke; Staurosporine; Tetradecanoylphorbol Acetate; Vascular Cell Adhesion Molecule-1 | 1994 |
Thrombin-induced increase of F-actin in human umbilical vein endothelial cells.
Topics: Actins; Alkaloids; Calcium; Capillary Permeability; Cells, Cultured; Cytoskeleton; Diterpenes; Endothelium, Vascular; Humans; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Umbilical Veins | 1994 |
Basal and acidic fibroblast growth factor-induced atrial natriuretic peptide gene expression and secretion is inhibited by staurosporine.
Topics: Alkaloids; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Gene Expression Regulation; Heart Ventricles; Myocardium; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Phorbol-stimulated influx of extracellular calcium in rat pulmonary artery endothelial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Bradykinin; Calcium; Calcium Channel Blockers; Cell Polarity; Endothelium, Vascular; Extracellular Space; Potassium; Protein Kinase C; Pulmonary Artery; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Staurosporine inhibits the anaphylactic reaction of the isolated guinea-pig heart.
Topics: Alkaloids; Anaphylaxis; Animals; Arachidonic Acids; Coronary Circulation; Dinoprost; Female; Guinea Pigs; Heart; Heart Rate; Hemodynamics; Histamine Release; In Vitro Techniques; Leukotrienes; Male; Ovalbumin; Radioimmunoassay; Staurosporine; Tetradecanoylphorbol Acetate; Ventricular Pressure | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Synergistic cooperation between phorbol ester and IFN-gamma for induction of nitric oxide synthesis in murine peritoneal macrophages.
Topics: Alkaloids; Amino Acid Oxidoreductases; Animals; Base Sequence; Cells, Cultured; Dactinomycin; DNA Primers; Drug Synergism; Gene Expression; Interferon-gamma; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mycobacterium bovis; Mycobacterium Infections; Nitric Oxide; Nitric Oxide Synthase; Polymyxin B; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line.
Topics: Alkaloids; Analysis of Variance; Animals; Cell Line; Cell Line, Transformed; Collagen; Enzyme Activation; Gene Expression; Glomerular Mesangium; Glucose; Kinetics; Luciferases; Mannitol; Mice; Mice, Inbred Strains; Naphthalenes; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1994 |
Interleukin-1 enhances beta-responsiveness of cardiac L-type calcium current suppressed by acidosis.
Topics: Acidosis; Alkaloids; Amiloride; Animals; Calcium Channels; Cells, Cultured; Guinea Pigs; Heart; Heart Ventricles; Humans; Interleukin-1; Isoproterenol; Kinetics; Male; Membrane Potentials; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Recombinant Proteins; Sodium; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Topics: Alkaloids; Arachidonate 12-Lipoxygenase; Carcinoma, Squamous Cell; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Humans; Naphthalenes; Phosphatidylinositol Phosphates; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Down-regulation of glycine receptor channels by protein kinase C in Xenopus oocytes injected with synthetic RNA.
Topics: Alkaloids; Amino Acid Sequence; Animals; Down-Regulation; Enzyme Activation; Female; Ion Channels; Kinetics; Molecular Sequence Data; Mutagenesis; Oocytes; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Glycine; RNA; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Xenopus | 1994 |
Investigations with the selective PKC inhibitor chelerythrine on human basophils.
Topics: Alkaloids; Basophils; Benzophenanthridines; Calcimycin; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Staurosporine can inhibit the G1-S transition induced by a calcium channel agonist by blocking the pathway independent of phorbol ester-sensitive protein kinase C in rat thyroid cells (FRTL-5).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channels; Cell Line; G1 Phase; Protein Kinase C; Rats; S Phase; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1994 |
Modulation of cytokine expression in PB-3c mastocytes by IBMX and PMA.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Alkaloids; Animals; Bone Marrow; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Diglycerides; Enzyme Activation; Gene Expression; Genes, ras; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Interleukin-6; Mast Cells; Mice; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Differential modulation by protein kinase C of progesterone-activated responses in human sperm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Membrane; Fluorescent Dyes; Fura-2; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Male; Membrane Potentials; Piperazines; Progesterone; Protein Kinase C; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Activation of a transfected FGFR-1 receptor in Madin-Darby epithelial cells results in a reversible loss of epithelial properties.
Topics: Actins; Alkaloids; Animals; Cell Division; Cell Line; Dogs; Electric Impedance; Epithelial Cells; Epithelium; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblasts; Humans; Keratins; Loop of Henle; Mice; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Vanadates | 1995 |
Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway.
Topics: Alkaloids; Animals; Cattle; Cells, Cultured; Flow Cytometry; Humans; Naphthalenes; Phagocytosis; Pigment Epithelium of Eye; Polycyclic Compounds; Protein Kinase C; Rod Cell Outer Segment; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Up-Regulation | 1994 |
Phosphopeptide mapping of cholecystokinin receptors on agonist-stimulated native pancreatic acinar cells.
Topics: Adenosine Triphosphate; Alkaloids; Amino Acid Sequence; Animals; Carbachol; Cell Membrane; Cholecystokinin; Cyanogen Bromide; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Molecular Sequence Data; Naphthalenes; Pancreas; Peptide Mapping; Phosphopeptides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Regulation of endothelial constitutive nitric oxide synthase by protein kinase C.
Topics: Alkaloids; Amino Acid Oxidoreductases; Animals; Benzophenanthridines; Cattle; Cells, Cultured; Endothelium, Vascular; Nitric Oxide Synthase; Phenanthridines; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Protein kinases and phosphatases modulate c-fos expression in rat hepatocytes. Effects of angiotensin II and phorbol myristate acetate.
Topics: Alkaloids; Angiotensin II; Animals; Ethers, Cyclic; Female; Gene Expression; Genes, fos; Genistein; Isoflavones; Marine Toxins; Microcystins; Naphthalenes; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Staurosporine blocks down-regulation of monocyte-associated tissue factor.
Topics: Alkaloids; Base Sequence; Cells, Cultured; Dactinomycin; Humans; Lipopolysaccharides; Molecular Sequence Data; Monocytes; Naphthalenes; Polycyclic Compounds; Polymerase Chain Reaction; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin | 1994 |
Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation.
Topics: Adult; Alkaloids; Analog-Digital Conversion; Biological Transport; Bucladesine; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Erythroid Precursor Cells; Erythropoietin; Genistein; Humans; Image Processing, Computer-Assisted; Indoles; Intercellular Signaling Peptides and Proteins; Intracellular Fluid; Isoflavones; Isoquinolines; Naphthalenes; Peptides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyrroles; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Videotape Recording; Wasp Venoms | 1994 |
Protein kinase C and phospholipase D activation in rat parotid glands.
Topics: Alkaloids; Animals; Benzophenanthridines; Enzyme Activation; Glycerophospholipids; Male; Naphthalenes; Parotid Gland; Phenanthridines; Phosphatidic Acids; Phospholipase D; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells.
Topics: Alkaloids; Animals; Biological Transport; Carbachol; Cell Membrane; Cells, Cultured; Enzyme Activation; Epithelial Cells; Epithelium; ErbB Receptors; Genistein; Isoenzymes; Isoflavones; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Receptor, Insulin; Salivary Glands; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Control of inositol phosphate turnover in human airways during histamine stimulation.
Topics: Alkaloids; Cells, Cultured; Chromatography, High Pressure Liquid; DNA; Histamine; Histamine Release; Humans; Inositol Phosphates; Muscle, Smooth; Protein Kinase C; Respiratory System; Staurosporine; Stimulation, Chemical; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Lack of involvement of protein kinase C in ethanol-induced inhibition of metabotropic-glutamate receptor function in primary cultures of astrocytes.
Topics: Alkaloids; Animals; Astrocytes; Cells, Cultured; Enzyme Activation; Ethanol; Female; Naphthalenes; Polycyclic Compounds; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation.
Topics: Alkaloids; Astrocytoma; Bucladesine; Calcimycin; Cholera Toxin; Humans; Indomethacin; Interleukin-6; Lipopolysaccharides; Receptors, Neurokinin-1; Staurosporine; Substance P; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Biphasic effect of staurosporine on thymocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Apoptosis; Bucladesine; Calcimycin; Carbazoles; Carcinogens; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Indole Alkaloids; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase Inhibitors; Radiation-Sensitizing Agents; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1995 |
Phorbol esters elicit Ca(2+)-dependent delayed contractions in diabetic rat aorta.
Topics: Alkaloids; Animals; Aorta; Body Weight; Calcium; Diabetes Mellitus, Experimental; Male; Muscle Contraction; Muscle, Smooth, Vascular; Organ Size; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Fertilization in Dictyostelium: pharmacological analyses and the presence of a substrate protein suggest protein kinase C is essential for gamete fusion.
Topics: Alkaloids; Animals; Benzophenanthridines; Dictyostelium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fertilization; Indoles; Kinetics; Maleimides; Membrane Fusion; Phenanthridines; Phosphoproteins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Phorbol ester potentiation of canine pulmonary vasoreactivity to histamine.
Topics: Alkaloids; Animals; Blood Vessels; Calcium Channel Blockers; Compliance; Dogs; Drug Synergism; Female; Histamine; In Vitro Techniques; Male; Naphthalenes; Nifedipine; Protein Kinase C; Pulmonary Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vascular Resistance | 1995 |
Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Alkaloids; Arachidonic Acid; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; Phospholipases A; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Alpha-adrenoceptors and angiotensinogen gene expression in opossum kidney cells.
Topics: Adrenergic alpha-Agonists; Affinity Labels; Alkaloids; Angiotensinogen; Animals; Cells, Cultured; Clonidine; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Kidney Tubules; Opossums; Phenylephrine; Prazosin; Protein Kinase C; Receptors, Adrenergic, alpha; Staurosporine; Tetradecanoylphorbol Acetate; Yohimbine | 1995 |
Effect of protein kinase C modulation on gonadotrophin-induced granulosa cell steroidogenesis.
Topics: Alkaloids; Animals; Cell Differentiation; Cyclic AMP; Female; Gonadotropins, Equine; Granulosa Cells; Pregnancy; Progesterone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Impaired hepatocanalicular organic anion transport in endotoxemic rats.
Topics: Alkaloids; Animals; Anions; Bile; Bile Canaliculi; Biological Transport; Dexamethasone; Endotoxins; Glutathione; Liver; Male; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
Topics: Alkaloids; Amino Acid Sequence; Animals; Antigens, CD; Binding Sites; DNA, Complementary; Epitopes; Humans; Interleukin-8; Molecular Sequence Data; Mutation; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Receptors, Interleukin; Receptors, Interleukin-8A; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Threonine; Tumor Cells, Cultured; Up-Regulation | 1995 |
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acids; Animals; Anti-Bacterial Agents; Cell Membrane; Chlorocebus aethiops; Diphtheria Toxin; DNA; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Macrolides; Molecular Weight; Piperazines; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Staurosporine; Tetradecanoylphorbol Acetate; Vero Cells | 1995 |
Interferon-gamma increases intracellular calcium and inositol phosphates in primary human thyroid cell culture.
Topics: Alkaloids; Calcium; Cell Line; Culture Media; Egtazic Acid; Enzyme Inhibitors; Genistein; Humans; Inositol Phosphates; Interferon-gamma; Isoflavones; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1995 |
Regulation of dihydropyridine and ryanodine receptor gene expression in skeletal muscle. Role of nerve, protein kinase C, and cAMP pathways.
Topics: Alkaloids; Animals; Blotting, Northern; Blotting, Western; Calcium Channels; Calcium Channels, L-Type; Cell Nucleus; Cells, Cultured; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Muscle Proteins; Muscle, Skeletal; Nerve Growth Factors; Nerve Tissue Proteins; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
Phorbol ester-stimulated 6-keto-prostaglandin F1 alpha in aortas from control and aldosterone-salt rats.
Topics: 6-Ketoprostaglandin F1 alpha; Aldosterone; Alkaloids; Animals; Aorta; Calcium; Dose-Response Relationship, Drug; Hypertension; Male; Norepinephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Chloride; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signalling molecules for cytoskeleton-dependent morphological changes in activated T cells.
Topics: Alkaloids; CD2 Antigens; CD3 Complex; Cell Membrane; Cell Size; Cytoskeleton; Enzyme Inhibitors; Humans; Hyaluronan Receptors; Intercellular Adhesion Molecule-1; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Protein Kinase C; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester-stimulated adherence of neutrophils to endothelial cells is reduced by adenosine A2 receptor agonists.
Topics: Adenylyl Cyclases; Alkaloids; Cell Adhesion; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Enzyme Activation; Humans; Neutrophils; Protein Kinase C; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit.
Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Male; Myocardial Infarction; Myocardium; Phenylisopropyladenosine; Polymyxin B; Protein Kinase C; Rabbits; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1995 |
Role of protein kinase C isozymes in Fc gamma receptor-mediated intracellular killing of Staphylococcus aureus by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Cross Reactions; Cross-Linking Reagents; Diglycerides; Humans; Isoenzymes; Isoquinolines; Molecular Sequence Data; Monocytes; Phagocytosis; Piperazines; Protein Kinase C; Reactive Oxygen Species; Receptors, IgG; Staphylococcus aureus; Staurosporine; Tetradecanoylphorbol Acetate; Translocation, Genetic; Type C Phospholipases | 1995 |
Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells.
Topics: Alkaloids; Carrier Proteins; Cholera Toxin; Choriocarcinoma; Cocaine; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Female; Humans; Isoquinolines; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Pregnancy; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1995 |
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Glycoproteins; Humans; Immunoenzyme Techniques; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Staurosporine; Synovial Membrane; Tetradecanoylphorbol Acetate; Thionucleotides; Tissue Inhibitor of Metalloproteinases; Up-Regulation | 1995 |
Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Calcimycin; Calcium; Calcium-Transporting ATPases; Cholera Toxin; Colforsin; Drug Synergism; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Isoquinolines; Leukemia-Lymphoma, Adult T-Cell; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; Endothelins; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Portal Vein; Potassium Chloride; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation | 1995 |
Involvement of protein kinase C activation in alpha 2-adrenoceptor-mediated contractions of rabbit saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Brimonidine Tartrate; Calcium; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Saphenous Vein; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.
Topics: Alkaloids; Animals; Antiviral Agents; Brefeldin A; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Line; Cyclopentanes; Flow Cytometry; Gene Expression; Genes, Viral; Immunity, Cellular; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lysosomes; Myxoma virus; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Upstream CREs participate in the basal activity of minute virus of mice promoter P4 and in its stimulation in ras-transformed cells.
Topics: Alkaloids; Animals; Base Sequence; Bucladesine; Cell Line; Cell Line, Transformed; Cell Nucleus; Cyclic AMP-Dependent Protein Kinases; DNA, Viral; Gene Expression Regulation, Viral; Genes, ras; Isoquinolines; Kinetics; Minute Virus of Mice; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Promoter Regions, Genetic; Rats; Rats, Inbred F344; Regulatory Sequences, Nucleic Acid; Staurosporine; Sulfonamides; TATA Box; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Viral Nonstructural Proteins | 1995 |
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Animals; Calcium; Calcium Channels; Cell Line; Dialysis; Egtazic Acid; Fura-2; Homeostasis; Indoles; Inositol 1,4,5-Trisphosphate; Kinetics; Leukemia, Basophilic, Acute; Maleimides; Patch-Clamp Techniques; Protein Kinase C; Protein Kinases; Rats; Receptors, Purinergic P1; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C.
Topics: Acetylcholine; Actins; Alkaloids; Carbachol; Cell Size; Culture Media; Cytochalasin B; Fluorescent Dyes; Humans; Indoles; Maleimides; Neurites; Neuroblastoma; Protein Kinase C; Receptors, Muscarinic; Receptors, Nicotinic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Angiotensin II activates the Na+/HCO3- symport through a phosphoinositide-independent mechanism in cardiac cells.
Topics: Alkaloids; Amiloride; Angiotensin II; Animals; Animals, Newborn; Arachidonic Acid; Benzopyrans; Bicarbonates; Carrier Proteins; Cells, Cultured; Dithiothreitol; Heart; Heart Rate; Heart Ventricles; Hydrogen-Ion Concentration; Kinetics; Myocardium; Naphthols; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rhodamines; Sodium-Bicarbonate Symporters; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Differential effect of protein kinase inhibitors (staurosporine and CGP 41,251) on TPA-induced homotypic aggregation and cell surface adhesion antigen expression in human monoblastoid cell line U-937.
Topics: Alkaloids; Cell Aggregation; Humans; Intercellular Adhesion Molecule-1; Lymphoma, Large B-Cell, Diffuse; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Effects of insulin, insulin-like growth factor-I, and phorbol esters on neutral cholesteryl esterase activity in cultured rat vascular smooth muscle cells.
Topics: Alkaloids; Animals; Aorta; Carbazoles; Cells, Cultured; Cyclic AMP; Indoles; Insulin; Insulin-Like Growth Factor I; Male; Muscle, Smooth, Vascular; Phenylurea Compounds; Phorbol Esters; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Staurosporine; Sterol Esterase; Sterol O-Acyltransferase; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester stimulated cathepsin L expression in U937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cathepsin L; Cathepsins; Cell Differentiation; Cycloheximide; Cysteine Endopeptidases; Drug Interactions; Endopeptidases; Enzyme Induction; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Monocytes; Neoplasm Proteins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1995 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression. Evidence that GM1-CD4 interaction triggers dissociation of p56lck from CD4, and CD4 internalization and degradation.
Topics: Alkaloids; Antibodies, Monoclonal; CD4 Antigens; Disulfides; Epitopes; Fluorescein-5-isothiocyanate; G(M1) Ganglioside; HeLa Cells; Humans; Kinetics; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Protein Conformation; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Regulation of cytokine-stimulated vascular cell adhesion molecule-1 expression in renal tubular epithelial cells.
Topics: Alkaloids; Animals; Cell Adhesion Molecules; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Activation; Epithelium; Female; Kidney Tubules; Mice; Mice, Inbred C3H; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 1993 |
Regulation of the TNF-alpha receptor in human osteosarcoma cells: role of microtubules and of protein kinase C.
Topics: Alkaloids; Cell Membrane; Cycloheximide; Ethers, Cyclic; Humans; Kinetics; Microtubules; Naphthalenes; Okadaic Acid; Osteosarcoma; Phosphoprotein Phosphatases; Polycyclic Compounds; Protein Kinase C; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine | 1993 |
Effect of a potent selective protein kinase C inhibitor on histamine release from rat mast cells.
Topics: Alkaloids; Animals; Calcimycin; Histamine Release; Immunoglobulin E; In Vitro Techniques; Mast Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Regulation of VCAM-1 expression and involvement in cell adhesion to murine microvascular endothelium.
Topics: Alkaloids; Animals; Cell Adhesion; Cell Adhesion Molecules; Cytokines; Endothelium, Vascular; Fibronectins; Gene Expression; Humans; In Vitro Techniques; Mice; Mice, Inbred DBA; Receptors, Leukocyte-Adhesion; RNA, Messenger; Rosette Formation; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1 | 1993 |
Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.
Topics: Alkaloids; Blotting, Western; Cycloheximide; Enzyme Activation; Humans; Interleukin-1; Kinetics; Naphthalenes; Polycyclic Compounds; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoquinolines; Liver Neoplasms, Experimental; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction | 1993 |
Involvement of protein kinase C in agonist-stimulated goldfish ovulation.
Topics: Alkaloids; Animals; Calcimycin; Dinoprost; Female; Goldfish; Hydrogen-Ion Concentration; In Vitro Techniques; Naphthalenes; Ovulation; Polycyclic Compounds; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vanadates | 1993 |
Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Induction; Extracellular Matrix; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Naphthalenes; Oligodeoxyribonucleotides; Piperazines; Plasminogen Activator Inhibitor 1; Polycyclic Compounds; Protein Kinase C; RNA; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1993 |
Evidence for the participation of protein kinase C and 3',5'-cyclic AMP-dependent protein kinase in the stimulation of muscle cell proliferation by 1,25-dihydroxy-vitamin D3.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Bucladesine; Calcitriol; Calcium; Calcium Channels; Cell Division; Cells, Cultured; Chick Embryo; Colforsin; Diglycerides; DNA; Dose-Response Relationship, Drug; Muscles; Nifedipine; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cells, Cultured; Cholecystokinin; Genistein; Isoflavones; Isoquinolines; Kinetics; Male; Pancreas; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Catechols; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gene Expression; Genes, fos; Genistein; Isoflavones; Kinetics; Myelin Basic Protein; Myocardium; Nitriles; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins | 1993 |
Potentiation of norepinephrine-induced contractions by endothelin-1 in the rabbit aorta.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Endothelins; In Vitro Techniques; Male; Naphthalenes; Norepinephrine; Polycyclic Compounds; Potassium; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction | 1993 |
A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC.
Topics: Alkaloids; Base Sequence; Cell Adhesion Molecules; Cell Membrane; Cells, Cultured; Cytosol; E-Selectin; Endothelium, Vascular; Humans; Indoles; Isoenzymes; Kinetics; Maleimides; Membrane Glycoproteins; Molecular Sequence Data; NF-kappa B; Oligonucleotide Probes; Phorbol Esters; Promoter Regions, Genetic; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1993 |
Staurosporine activates a 60,000 M(r) protein kinase in bovine chromaffin cells that phosphorylates myelin basic protein in vitro.
Topics: Adenosine Triphosphate; Adrenal Glands; Alkaloids; Animals; Cattle; Chromaffin System; Enzyme Activation; Immunoblotting; Kinetics; Molecular Weight; Myelin Basic Protein; Phosphorylation; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Differential modulation of P-glycoprotein transport by protein kinase inhibition.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carrier Proteins; Cyclosporine; Dactinomycin; Dihydropyridines; Drug Resistance; Humans; Isoenzymes; Membrane Glycoproteins; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1993 |
The cytoplasmic domain of P-selectin is phosphorylated on serine and threonine residues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Alprostadil; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; P-Selectin; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Platelet Membrane Glycoproteins; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins | 1993 |
Stimulation of human basophils results in homotypic aggregation. A response independent of degranulation.
Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; Basophils; CD18 Antigens; Cell Aggregation; Cell Degranulation; Histamine Release; Humans; Immunoglobulin E; N-Formylmethionine Leucyl-Phenylalanine; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Receptor-evoked Ca2+ mobilization in pancreatic acinar cells: evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state.
Topics: Alkaloids; Animals; Brain; Calcium; Carbachol; Cholecystokinin; Fura-2; Inosine Triphosphate; Naphthalenes; Pancreas; Phosphorylation; Polycyclic Compounds; Proglumide; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
CGP 41251, a novel protein kinase inhibitor with in vitro selectivity for protein kinase C, strongly inhibits immunological activation of human skin mast cells and human basophils.
Topics: Alkaloids; Basophils; Dinoprostone; Female; Histamine Release; Humans; Leukotrienes; Mast Cells; Protein Kinase C; Receptors, IgE; Signal Transduction; Skin; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Inhibition of intercellular communication via gap junction in cultured aortic endothelial cells by elevated glucose and phorbol ester.
Topics: Alkaloids; Animals; Aorta; Cattle; Cell Communication; Cells, Cultured; Endothelium, Vascular; Gap Junctions; Glucose; In Vitro Techniques; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Triazines | 1995 |
Cellular and molecular mechanisms that mediate insulin-dependent rat granulosa cell mitosis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Female; Gene Expression; Genes, fos; Genes, jun; Granulosa Cells; Insulin; Mitosis; Molecular Sequence Data; Oligonucleotides, Antisense; Progesterone; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Protein kinase C regulates calmodulin expression in NRK cells activated to proliferate from quiescence.
Topics: Alkaloids; Animals; Calmodulin; Cattle; Cell Division; Cell Line; Contact Inhibition; Culture Media; Culture Media, Serum-Free; Cyclic AMP-Dependent Protein Kinases; DNA Replication; Epithelial Cells; Epithelium; Fetal Blood; Gene Expression Regulation; Ionomycin; Isoquinolines; Kidney; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor.
Topics: Alkaloids; Amyloid; Carbachol; Cell Line; Genistein; Humans; Isoflavones; Phosphorylation; Prion Proteins; Prions; Protein Kinase Inhibitors; Protein Precursors; Protein Tyrosine Phosphatases; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Superoxide generation by guinea-pig peritoneal macrophages is inhibited by rolipram, staurosporine and mepacrine in an agonist-dependent manner.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Macrophages, Peritoneal; Male; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Platelet Activating Factor; Protein Kinase C; Pyrrolidinones; Quinacrine; Respiratory Burst; Rolipram; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
IL-1 receptor and TCR signals synergize to activate NF-kappa B-mediated gene transcription.
Topics: Alkaloids; CD3 Complex; Cell Nucleus; Cyclosporine; Cytoplasm; DNA-Binding Proteins; Gene Expression Regulation; Humans; In Vitro Techniques; Interleukin-1; NF-kappa B; Protein Kinase C; Receptors, Antigen, T-Cell; Receptors, Interleukin-1; RNA, Messenger; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 1995 |
Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Blotting, Northern; Cells, Cultured; Collagenases; Cycloheximide; Dose-Response Relationship, Drug; Fetus; Fibroblast Growth Factor 2; Gene Expression; Glycoproteins; Indomethacin; Kinetics; Matrix Metalloproteinase 1; Osteoblasts; Protein Kinase C; Pyrimidine Nucleosides; Rats; Recombinant Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic | 1995 |
Impaired phorbol ester-induced hepatocyte proliferation in cirrhosis.
Topics: Alkaloids; Animals; Cell Division; Cell Separation; DNA; Liver; Liver Cirrhosis, Experimental; Male; Protein Kinase C; Rats; Rats, Wistar; Reference Values; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Effect of phorbol ester on phosphoinositide hydrolysis and calcium mobilization induced by endothelin-1 in cultured canine tracheal smooth muscle cells.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Diglycerides; Dogs; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Endothelins; Hydrolysis; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Activation of protein kinase C enhances the phosphorylation of the type B interleukin-8 receptor and stimulates its degradation in non-hematopoietic cells.
Topics: Alkaloids; Cell Line; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Diglycerides; Down-Regulation; Enzyme Activation; Growth Substances; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Pertussis Toxin; Phosphorylation; Phosphoserine; Placenta; Protein Kinase C; Receptors, Interleukin; Receptors, Interleukin-8A; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 1995 |
Protein kinase C-independent inhibition of the Ca(2+)-activated K+ channel by angiotensin II and endothelin-1.
Topics: Alkaloids; Angiotensin II; Animals; Calcimycin; Cells, Cultured; Coronary Vessels; Endothelins; Large-Conductance Calcium-Activated Potassium Channels; Membrane Proteins; Muscle, Smooth, Vascular; Neomycin; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Protein Kinase C; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1995 |
Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization.
Topics: Actins; Alkaloids; Animals; Biopolymers; Diglycerides; Dinitrophenols; Enzyme Activation; Immunologic Capping; Leukemia, Basophilic, Acute; Neoplasm Proteins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Rats; Receptors, IgE; Serum Albumin, Bovine; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Specificity of phospholipase D activation by cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini.
Topics: Alkaloids; Animals; Calcimycin; Carbachol; Ceruletide; Cholecystokinin; Choline; Egtazic Acid; Enzyme Activation; Glycerophospholipids; In Vitro Techniques; Male; Pancreas; Phosphatidic Acids; Phospholipase D; Phosphorylcholine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1995 |
Potential role of protein phosphorylation in GTP-gamma-S-dependent activation of phospholipase D.
Topics: Adenosine Triphosphate; Alkaloids; Cell Line; Enzyme Activation; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoflavones; Phospholipase D; Phosphorylation; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Down-regulation of protein kinase C attenuates the oxidant hydrogen peroxide-mediated activation of phospholipase A2 in pulmonary vascular smooth muscle cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Gallic Acid; Hydrogen Peroxide; Muscle, Smooth, Vascular; Oxidants; Phospholipases A; Phospholipases A2; Protein Kinase C; Pulmonary Artery; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Pituitary adenylate cyclase-activating polypeptide autoregulates cAMP production due to activation of protein kinase C in PC12 pheochromocytoma cells.
Topics: Alkaloids; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Homeostasis; Neuropeptides; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase C; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes.
Topics: Alkaloids; Animals; Anion Transport Proteins; Bile Canaliculi; Biological Transport; Carrier Proteins; Cell Membrane; Cells, Cultured; Glutathione; Kinetics; Liver; Male; Methylamines; Mice; Mice, Mutant Strains; Monensin; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Temperature; Tetradecanoylphorbol Acetate | 1995 |
Evidence for involvement of phosphatidylcholine-phospholipase C and protein kinase C in transforming growth factor-beta signaling.
Topics: Alkaloids; Bridged-Ring Compounds; GTP-Binding Proteins; Humans; Norbornanes; Phosphatidylcholines; Plasminogen Activator Inhibitor 1; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Transforming Growth Factor beta; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Effects of protein kinase modulators on transferrin receptor expression in human leukaemic HL-60 cells.
Topics: Alkaloids; Bucladesine; Cell Division; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Enzyme Activation; Gene Expression; Humans; Indoles; Isoquinolines; Leukemia, Promyelocytic, Acute; Maleimides; Protein Kinase C; Protein Kinases; Receptors, Transferrin; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1995 |
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Analysis of Variance; Animals; Calcium; Cattle; Cells, Cultured; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expression Regulation, Enzymologic; Nucleic Acid Hybridization; Parathyroid Glands; Parathyroid Hormone; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; RNA, Ribosomal, 18S; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1995 |
Receptor-mediated modulation of rat KV1.2 in Xenopus oocytes.
Topics: Alkaloids; Animals; Calcium; Myocardium; Oocytes; Patch-Clamp Techniques; Phosphatidylinositols; Plasmids; Potassium Channels; Protein Kinase C; Rats; Receptors, Endothelin; RNA, Complementary; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus | 1994 |
Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Aluminum; Animals; Biological Transport; Calcium; Clone Cells; Cytosol; Diacylglycerol Kinase; DNA; Dogs; Gadolinium; Growth Substances; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neomycin; Osteoblasts; Phosphorus Radioisotopes; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Proteins; Receptors, Calcium-Sensing; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Increased internal Ca2+ mediates neural induction in the amphibian embryo.
Topics: Alkaloids; Animals; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Concanavalin A; Ectoderm; Embryonic Induction; In Vitro Techniques; Ion Channel Gating; Isradipine; Nervous System; Nimodipine; Pleurodeles; Protein Kinase C; Ryanodine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Endothelin-1 modulates renin and prolactin release from human decidua by different mechanisms.
Topics: Alkaloids; Calcimycin; Decidua; Endothelins; Female; Humans; Nifedipine; Prolactin; Renin; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Cell Division; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver Neoplasms, Experimental; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Regulation of monocyte chemoattractant protein-1 gene expression and secretion in rat pulmonary alveolar macrophages by lipopolysaccharide, tumor necrosis factor-alpha, and interleukin-1 beta.
Topics: Alkaloids; Animals; Base Sequence; Chemokine CCL2; Chemotactic Factors; Chemotaxis, Leukocyte; Gene Expression Regulation; Interleukin-1; Lipopolysaccharides; Macrophage Activation; Macrophages, Alveolar; Male; Molecular Sequence Data; Protein Kinase C; Rats; RNA, Messenger; Specific Pathogen-Free Organisms; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Effects of low-density lipoproteins on polymorphonuclear leukocyte functions in vitro.
Topics: Alkaloids; Amino Acid Sequence; Cell Survival; Chemotaxis, Leukocyte; Complement C5a; Humans; Leukocyte Migration-Inhibitory Factors; Lipoproteins, LDL; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1994 |
Inhibitory effects of quercetin and staurosporine on phasic contractions in rat vascular smooth muscle.
Topics: Alkaloids; Animals; Aorta; Caffeine; Calcium; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Serotonin; Sodium; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Activation of protein kinase C in the hypothalamic ventromedial nucleus or the midbrain central gray facilitates lordosis.
Topics: Alkaloids; Animals; Cholesterol; Enzyme Activation; Estradiol; Female; Infusions, Parenteral; Male; Mesencephalon; Mifepristone; Ovariectomy; Phorbol Esters; Posture; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Staurosporine; Tetradecanoylphorbol Acetate; Ventromedial Hypothalamic Nucleus | 1994 |
Effect of phorbol 12-myristate 13-acetate on hypoxanthine transport in LLC-PK1 renal epithelia.
Topics: Alkaloids; Animals; Biological Transport, Active; Cycloheximide; Epithelium; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; LLC-PK1 Cells; Protein Kinase C; Sodium; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1994 |
Functional expression of a stably transfected parathyroid hormone/parathyroid hormone related protein receptor complementary DNA in CHO cells.
Topics: Alkaloids; Animals; Calcium; CHO Cells; Cricetinae; Cyclic AMP; DNA, Complementary; Kidney; Opossums; Parathyroid Hormone-Related Protein; Peptide Fragments; Phosphates; Protein Kinase C; Proteins; Receptor, Parathyroid Hormone, Type 1; Receptors, Parathyroid Hormone; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Regulation by phorbol esters of the glycine transporter (GLYT1) in glioblastoma cells.
Topics: Alkaloids; Amino Acid Transport Systems, Neutral; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; Glioblastoma; Glycine; Glycine Plasma Membrane Transport Proteins; Molecular Sequence Data; Neuroglia; Oligonucleotides, Antisense; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons.
Topics: Alkaloids; Animals; Antibodies; Axons; Benzoquinones; Cells, Cultured; Dendrites; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblast Growth Factor 2; Hippocampus; Humans; Lactams, Macrocyclic; Neurites; Neurons; Phenols; Polysaccharide-Lyases; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Recombinant Proteins; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo.
Topics: 3T3 Cells; Alkaloids; Animals; Anticarcinogenic Agents; Female; Isoenzymes; Mice; Mice, Inbred Strains; Protein Kinase C; Skin; Skin Neoplasms; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1995 |
Inhibition of cardiac myocyte maturation by 1,25-dihydroxyvitamin D3.
Topics: Alkaloids; Animals; Calcitriol; Cell Differentiation; Cells, Cultured; Creatine Kinase; Culture Media; Heart Ventricles; Isoenzymes; Myocardium; Myosins; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Mutual antagonistic interactions between the thyrotropin (adenosine 3',5'-monophosphate) and protein kinase C/epidermal growth factor (tyrosine kinase) pathways in cell proliferation and differentiation of cultured human thyroid follicles.
Topics: Alkaloids; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Epidermal Growth Factor; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein-Tyrosine Kinases; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1995 |
Nitric oxide synthesis and its regulation by rabbit synoviocytes.
Topics: Alkaloids; Animals; Cell Line; Cells, Cultured; Cytokines; Dinoprostone; Fibroblasts; Free Radicals; Interferon-gamma; Interleukin-1; Metalloendopeptidases; Nitric Oxide; Platelet-Derived Growth Factor; Protein Kinase C; Rabbits; Staurosporine; Synovial Membrane; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 1994 |
Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol.
Topics: Alkaloids; Blotting, Northern; Cholestanones; Cholesterol; Culture Media, Serum-Free; Gene Expression Regulation, Viral; HeLa Cells; Humans; Papillomaviridae; Protein Kinase C; RNA, Viral; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Thrombin and phorbol ester induce internalization of thrombin receptor of human mesangial cells through different pathways.
Topics: Alkaloids; Cell Membrane Permeability; Glomerular Mesangium; Humans; Indoles; Maleimides; Peptide Fragments; Protein Kinase C; Receptors, Thrombin; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1995 |
Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol.
Topics: Alkaloids; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cells, Cultured; Edetic Acid; Enzyme Induction; Gene Expression Regulation; Gossypol; Humans; Intracellular Fluid; Macrophage-1 Antigen; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Phosphorylation; Protein Kinase C; Respiratory Burst; Signal Transduction; Staurosporine; Stereoisomerism; Structure-Activity Relationship; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Up-Regulation | 1994 |
Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Ketoprostaglandin F1 alpha; Alkaloids; Cells, Cultured; Endothelium, Vascular; Humans; Interleukin-1; Isoquinolines; Lipopolysaccharides; Lyngbya Toxins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells.
Topics: Alkaloids; Apoproteins; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Endothelins; Humans; Kidney Tubules, Proximal; Lipoproteins, HDL; Protein Kinase C; Serum Albumin, Bovine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells.
Topics: Alkaloids; Animals; Blotting, Northern; Cell Division; Cholera Toxin; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Neoplastic; Growth Hormone; GTP-Binding Proteins; HSP70 Heat-Shock Proteins; Interleukin-2; Lymphoma; Pertussis Toxin; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Effect of endothelin-1 on phospholipase D activity in osteoblast-like cells.
Topics: Alkaloids; Animals; Cell Line; Choline; Drug Synergism; Endothelins; Enzyme Activation; Inositol Phosphates; Mice; Osteoblasts; Pertussis Toxin; Phospholipase D; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Activation of protein kinase C inhibits ATP-induced [Ca2+]i elevation in rat osteoblastic cells: selective effects on P2Y and P2U signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Isoquinolines; Osteoblasts; Piperazines; Protein Kinase C; Rats; Receptors, Purinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Regulation by protein kinase C of platelet-activating factor- and thapsigargin-induced calcium entry in rabbit neutrophils.
Topics: Alkaloids; Animals; Calcium; Calcium Chloride; Calcium-Transporting ATPases; Cytosol; Electrophysiology; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Spectrometry, Fluorescence; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Induction of c-fos in pituitary cells by thyrotrophin-releasing hormone and phorbol 12-myristate 13-acetate depends upon Ca2+ influx.
Topics: Alkaloids; Animals; Calcium; Cell Line; Culture Media, Serum-Free; Cytoplasm; Down-Regulation; Edetic Acid; Egtazic Acid; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Phorbol 12,13-Dibutyrate; Pituitary Gland; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1994 |
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
Topics: Alkaloids; Arachidonic Acid; Carrier Proteins; Chlorides; Cystic Fibrosis; Diglycerides; Epinephrine; Epithelium; Humans; Isoproterenol; Methoxamine; Nasal Polyps; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoproteins; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium Chloride Symporters; Staurosporine; Symporters; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1995 |
Protein kinase C and CYP1A1 induction in rainbow trout (Oncorhynchus mykiss) hepatocyte culture.
Topics: Alkaloids; Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diglycerides; Enzyme Induction; Liver; Oncorhynchus mykiss; Oxidoreductases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells.
Topics: Alkaloids; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; Cell Fusion; Cell Line; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Drug Interactions; Giant Cells; HIV Envelope Protein gp120; HIV Envelope Protein gp41; HIV-1; Humans; Membrane Fusion; Models, Biological; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virus Replication | 1994 |
Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.
Topics: 3T3 Cells; Alkaloids; Animals; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Genistein; Glycerophospholipids; Inositol Phosphates; Isoenzymes; Isoflavones; Mice; Phosphatidic Acids; Phospholipase C gamma; Phospholipase D; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1994 |
Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the alpha isozyme mediates both potentiation and desensitization.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alkaloids; Aluminum Compounds; Animals; Brain; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fluorides; GTP-Binding Proteins; Humans; Isoenzymes; Isoproterenol; Kinetics; Manganese; Neuroblastoma; Neuropeptide Y; Propanolamines; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.
Topics: Adenylyl Cyclases; Alkaloids; Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Cell Line; Chromatography, Affinity; DNA Primers; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Immune Sera; Isoenzymes; Kinetics; Mammals; Molecular Sequence Data; Peptides; Phosphorylation; Protein Kinase C; Rabbits; Recombinant Proteins; Signal Transduction; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Protein kinase C mediates the calcium-induced activation of rat colonic particulate guanylate cyclase.
Topics: Alkaloids; Animals; Calcium; Colon; Enzyme Activation; Estrenes; Guanylate Cyclase; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation.
Topics: Alkaloids; Animals; Azepines; Calcium; Cell Membrane; Cytosol; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Male; Peritoneal Lavage; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triazoles | 1994 |
The epidermal growth factor receptor in the human endometrial adenocarcinoma cell line HEC-1-B.
Topics: Adenocarcinoma; Alkaloids; Binding Sites; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Estradiol; Female; Humans; Kinetics; Progesterone; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.
Topics: Alkaloids; Androgens; Apoptosis; Carcinoma; DNA Damage; DNA-Binding Proteins; DNA, Neoplasm; Early Growth Response Protein 1; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Protein Kinases; Proto-Oncogene Proteins c-fos; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1994 |
Mechanisms involved in the processing of the p55 and the p75 tumor necrosis factor (TNF) receptors to soluble receptor forms.
Topics: Alkaloids; Ammonium Chloride; Bucladesine; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Endopeptidases; Enzyme-Linked Immunosorbent Assay; HeLa Cells; Humans; Leukemia, Monocytic, Acute; Leukemia, Promyelocytic, Acute; Monensin; Neoplasm Proteins; Protein Kinase C; Protein Processing, Post-Translational; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Solubility; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor Decoy Receptors | 1994 |
Functional role of phosphorylation of the multidrug transporter (P-glycoprotein) by protein kinase C in multidrug-resistant MCF-7 cells.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cycloheximide; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Phosphorylation; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Vinblastine | 1994 |
Entamoeba histolytica: PKC transduction pathway activation in the trophozoite-fibronectin interaction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Entamoeba histolytica; Enzyme Activation; Fibronectins; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protozoan Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities.
Topics: Alkaloids; Cells, Cultured; Collagen; Collagenases; Enzyme Induction; Genes, fos; Genistein; GTP-Binding Proteins; Humans; Isoflavones; Keratinocytes; Prostaglandins; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Alkaloids; Animals; Bucladesine; Calcimycin; Calmodulin; Cell Line; Colforsin; Culture Media; Cytoplasm; Dyneins; Edetic Acid; Ethers, Cyclic; Imidazoles; Kidney; Kinetics; Macromolecular Substances; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Regulated internalization of caveolae.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Biological Transport; Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cytochalasin D; Ethers, Cyclic; Genistein; Hypertonic Solutions; Isoflavones; Membrane Proteins; Microscopy, Electron; Microtubules; Nocodazole; Okadaic Acid; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41,251 on PMN locomotion, cell polarity, and pinocytosis.
Topics: Alkaloids; Amino Acid Sequence; Cell Movement; Cell Polarity; Cell Size; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Indoles; Molecular Sequence Data; Molecular Weight; Neutrophils; Oligopeptides; Phosphoproteins; Pinocytosis; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Prostaglandin F2 alpha activates phospholipase D independently from activation of protein kinase C in osteoblast-like cells.
Topics: Alkaloids; Cell Line; Choline; Dinoprost; Enzyme Activation; GTP-Binding Proteins; Hydrolysis; Osteoblasts; Pertussis Toxin; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Induction of the collagenase phorbol ester response element by staurosporine.
Topics: Alkaloids; Animals; Cell Line; Cell Line, Transformed; Collagen; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Edetic Acid; Fibroblasts; Gene Expression; Genes, jun; Genes, ras; Isoquinolines; Kinetics; Oncogene Protein p65(gag-jun); Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-jun; Rats; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Coupling of pancreatic gastrin/cholecystokinin-B (G/CCKB) receptors to phospholipase C and protein kinase C in AR4-2J tumoral cells.
Topics: Alkaloids; Animals; Binding Sites; Cholecystokinin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Gastrins; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ornithine Decarboxylase; Pancreas; Pancreatic Neoplasms; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Rats; Receptors, Cholecystokinin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1994 |
Proliferating cell nuclear antigen decreases in normal human keratinocytes with differentiation stimuli but not in an HPV immortalised cell line.
Topics: Alkaloids; Calcitriol; Cell Line, Transformed; Fluorescent Antibody Technique; Humans; Keratinocytes; Papillomaviridae; Phorbol Esters; Proliferating Cell Nuclear Antigen; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1994 |
Protein kinase C activity does not mediate the inhibitory effect of carbachol on chloride secretion by T84 cells.
Topics: Alkaloids; Calcium; Carbachol; Cell Line; Chlorides; Colon; Humans; Inositol Phosphates; Intestinal Mucosa; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Regulation of T-cell-receptor-stimulated bivalent-cation entry in Jurkat E6 cells: role of protein kinase C.
Topics: Alkaloids; Antibodies, Monoclonal; Antigen-Antibody Complex; Calcium; CD3 Complex; Cell Line; Enzyme Activation; Fura-2; Indoles; Maleimides; Manganese; Protein Kinase C; Receptors, Antigen, T-Cell; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
The role of protein kinase C in arachidonic acid release and prostaglandin E production from CHO cells transfected with EGF receptors.
Topics: Alkaloids; Animals; Arachidonic Acid; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Phospholipases A; Phospholipases A2; Prostaglandins E; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Staurosporine and its derivatives enhance f-Met-Leu-Phe-induced superoxide production via phospholipase D activation in human polymorphonuclear leukocytes.
Topics: Alkaloids; Amino Acid Sequence; Carbazoles; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Humans; Indole Alkaloids; Male; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Phosphorylation and expression of connexin-43 ovarian gap junction protein are regulated by luteinizing hormone.
Topics: Alkaloids; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Colforsin; Connexin 43; Electrophoresis, Polyacrylamide Gel; Female; Gap Junctions; Gene Expression; Granulosa Cells; Kinetics; Luteinizing Hormone; Meiosis; Ovarian Follicle; Ovary; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators.
Topics: Alkaloids; Animals; Cell Line; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Glomerular Mesangium; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1994 |
Partial purification of a type eta protein kinase C from murine brain: separation from other protein kinase C isoenzymes and characterization.
Topics: Alkaloids; Amino Acid Sequence; Animals; Baculoviridae; Brain; Bryostatins; Cell Line; Chromatography; Cytosol; Enzyme Activation; Gene Transfer Techniques; Immunosorbent Techniques; Isoenzymes; Lactones; Macrolides; Mice; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Recombinant Proteins; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
Topics: Affinity Labels; Alkaloids; Binding Sites; Biological Transport; Cell Differentiation; Dilazep; Dipyridamole; Humans; Kinetics; Leukemia; Monocytes; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thioinosine; Thymidine; Tumor Cells, Cultured; Uracil; Uridine | 1994 |
Prostaglandin E2/parathyroid hormone-induced suppression of alkaline phosphatase activity is mediated by protein kinase C.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Bucladesine; Calcimycin; Cyclic AMP; Cycloheximide; Dinoprostone; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Selective down-regulation of protein kinase c-epsilon by carcinogens does not prevent stimulation of phospholipase D by phorbol ester and platelet-derived growth factor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Isoenzymes; Mice; Mice, Inbred C3H; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Platelet-Derived Growth Factor; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Lipopolysaccharide-mediated signal transduction through phospholipase D activation in monocytic cell lines.
Topics: Alkaloids; Calcium; Diglycerides; Enzyme Activation; Glycerophospholipids; Humans; Lipopolysaccharides; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Spontaneous injury to human umbilical vein endothelial cells increases during in vitro culture and is blocked by protein kinase activation.
Topics: Alkaloids; Catalase; Cell Death; Cells, Cultured; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Enzyme Activation; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Humans; Iron Chelating Agents; Protein Kinase C; Protein Kinases; Spin Labels; Staurosporine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Umbilical Veins | 1994 |
In vivo phosphorylation of the Na,K-ATPase alpha subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators.
Topics: Alkaloids; Animals; Blotting, Western; Calcium; Colforsin; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Kinetics; Macromolecular Substances; Male; Membrane Proteins; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Reference Values; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C and mammary cell differentiation: involvement of protein kinase C alpha in the induction of beta-casein expression.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Caseins; Cell Differentiation; Cell Line; Dexamethasone; Epithelial Cells; Epithelium; Female; Gene Expression Regulation; Insulin; Isoenzymes; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Pregnancy; Prolactin; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Ca2+ efflux from platelets. Control by protein kinase C and the filling state of the intracellular Ca2+ stores.
Topics: Alkaloids; Blood Platelets; Calcium; Calcium Radioisotopes; Calcium-Transporting ATPases; Cytoplasmic Granules; Cytosol; Dose-Response Relationship, Drug; Egtazic Acid; Exocytosis; Fluorescent Dyes; Humans; In Vitro Techniques; Indoles; Ionomycin; Kinetics; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin | 1994 |
Interleukin-1 alpha suppresses gap junction-mediated intercellular communication in human endothelial cells.
Topics: Alkaloids; Calcium; Cell Communication; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Intercellular Junctions; Interleukin-1; Kinetics; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Umbilical Veins | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells.
Topics: Alkaloids; Calcimycin; Cysteine; Down-Regulation; Eosinophils; Glutathione Transferase; Humans; Leukemia, Promyelocytic, Acute; Leukotrienes; Nitriles; Phenols; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrphostins | 1994 |
Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa B following tumour necrosis factor treatment of chronic B-leukaemia cells.
Topics: Acetylcysteine; Alkaloids; Base Sequence; Butylated Hydroxytoluene; DNA-Binding Proteins; Humans; In Vitro Techniques; Leukemia, B-Cell; Leukemia, Hairy Cell; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Oxidation-Reduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F.
Topics: Alkaloids; Animals; Catechols; Cell Line; Cyclosporine; Enzyme Activation; Genistein; Insulin; Interleukin-1; Isoflavones; Nitric Oxide; Nitriles; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins | 1994 |
Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.
Topics: Alkaloids; Base Sequence; Cell Differentiation; Humans; Molecular Sequence Data; Neuroblastoma; Neuropeptide Y; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
High glucose attenuates peptide agonist-evoked increases in cytosolic free [Ca2+] in rat aortic smooth muscle cells.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Arginine Vasopressin; Calcium; Cells, Cultured; Culture Media; Cytosol; Endothelins; Glucose; Male; Mannose; Muscle, Smooth, Vascular; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C signal transduction pathway in ACTH-induced growth effect of rat adrenocortical cells in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenocorticotropic Hormone; Alkaloids; Animals; Cell Division; Cells, Cultured; Corticosterone; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Regulation of heparin binding-epidermal growth factor like growth factor gene expression by LDL and oxidized-LDL in rat mesangial cells.
Topics: Alkaloids; Animals; Blotting, Northern; Epidermal Growth Factor; Gene Expression Regulation; Glomerular Mesangium; Heparin; Kinetics; Lipoproteins, LDL; Male; Oxidation-Reduction; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Phorbol ester-induced inhibition of GABA uptake by synaptosomes and by Xenopus oocytes expressing GABA transporter (GAT1).
Topics: Alkaloids; Animals; Base Sequence; Brain; Carrier Proteins; Cerebral Cortex; DNA, Complementary; Female; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Library; Kinetics; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nipecotic Acids; Oligonucleotide Probes; Oocytes; Organic Anion Transporters; Proline; Protein Kinase C; Rats; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate; Xenopus | 1994 |
Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells.
Topics: Adipocytes; Alkaloids; Animals; Biological Transport; Blotting, Western; Drug Antagonism; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Male; Monosaccharide Transport Proteins; Muscle Proteins; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium.
Topics: Alkaloids; Animals; Biological Transport; Colchicine; Female; Male; Microtubules; Myocardial Ischemia; Myocardium; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Is protein kinase C activity required for the N-methyl-D-aspartate-evoked rise in cytosolic Ca2+ in mouse striatal neurons?
Topics: Alkaloids; Animals; Biological Transport; Calcium; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium Chloride; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Downregulation of Fc gamma receptor IIIA alpha (CD16-II) on natural killer cells induced by anti-CD16 mAb is independent of protein tyrosine kinases and protein kinase C.
Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Down-Regulation; Genistein; Humans; In Vitro Techniques; Isoflavones; Killer Cells, Natural; Lectins, C-Type; Metalloendopeptidases; Phenanthrolines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Receptors, Interleukin-2; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zinc | 1994 |
Effect of phorbol 12-myristate 13-acetate on Ca2+-ATPase activity in rat liver nuclei.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcium-Transporting ATPases; Cell Nucleus; Dibucaine; Enzyme Activation; Liver; Male; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates | 1994 |
Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Cell Membrane; Chemotaxis, Leukocyte; Cytochalasin B; Down-Regulation; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Neutrophils; Phospholipase D; Protein Kinase C; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Does protein kinase C regulate receptor agonists-mediated elevation in the cytosolic Ca2+ in human neutrophils?
Topics: Alkaloids; Calcium; Cytosol; Enzyme Activation; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation; Glioma; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine
Topics: Alkaloids; Androstadienes; Antigens, CD; CD18 Antigens; Genistein; Integrins; Isoflavones; Lymphocyte Function-Associated Antigen-1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella; Wortmannin | 1993 |
Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; In Vitro Techniques; Leukemia P388; Membrane Glycoproteins; Mice; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinblastine | 1993 |
Increased protein kinase C activity in human memory T cells.
Topics: Alkaloids; Antigens, Differentiation, T-Lymphocyte; Clone Cells; Dipeptidyl Peptidase 4; Humans; Immunologic Memory; Lymphocyte Activation; Phytohemagglutinins; Protein Kinase C; Receptors, Interleukin-2; Staurosporine; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate | 1993 |
LFA-1 and ICAM-1 in homotypic aggregation of rat alveolar macrophages: organic dust-mediated aggregation by a non-protein kinase C-dependent pathway.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Aggregation; Dust; Edible Grain; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Macrophages, Alveolar; Male; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Wool | 1993 |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
1,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Calcitriol; Cell Membrane; Colon; Enzyme Activation; Estrenes; Guanylate Cyclase; Kinetics; Male; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Lung Neoplasms; Membrane Glycoproteins; Neoplasms; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Protein kinase C activates capacitative calcium entry in the insulin secreting cell line RINm5F.
Topics: Alkaloids; Animals; Biological Transport; Calcium; Cytosol; Insulin; Insulin Secretion; Insulinoma; Manganese; Pancreatic Neoplasms; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1994 |
Induction of FOS and JUN proteins by adrenocorticotropin and phorbol ester but not by 3',5'-cyclic adenosine monophosphate derivatives.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Alkaloids; Animals; Bucladesine; Colforsin; Cycloheximide; Dactinomycin; Enzyme Induction; Genes, fos; Genes, jun; Kinetics; Mice; Neoplasm Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
1,25-Dihydroxyvitamin D3 and phorbol myristate acetate synergistically increase carbonic anhydrase-II expression in a human myelomonocytic cell line.
Topics: Alkaloids; Calcitriol; Carbonic Anhydrases; Drug Synergism; Gene Expression Regulation, Enzymologic; Humans; Leukemia, Promyelocytic, Acute; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells.
Topics: Alkaloids; Angiotensin II; Animals; Cells, Cultured; Eukaryotic Initiation Factor-4E; Male; Muscle, Smooth, Vascular; Peptide Initiation Factors; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Chelating Agents; Enzyme Activation; Hydrogen Peroxide; Hydrolysis; Mice; Phenanthrolines; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1994 |
Protein kinase C activation promotes cell survival in mature lymphocytes prone to apoptosis.
Topics: Alkaloids; Animals; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Lymphocytes; Polymyxin B; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Alkaloids; Animals; Enzyme Activation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Pyridazines; Rats; Rats, Wistar; Serotonin; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C activation of phospholipase D in C6 glioma cells.
Topics: Alkaloids; Animals; Cell Line; Enzyme Activation; Glioma; Indoles; Phorbol Esters; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells.
Topics: Alkaloids; Animals; Benzoquinones; Cell Line; Interleukin-1; Interleukin-2; Kinetics; Lactams, Macrocyclic; Mice; NF-kappa B; Oxidation-Reduction; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured | 1993 |
The involvement of protein kinase C in glucose-stimulated insulin secretion.
Topics: Alkaloids; Animals; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Isoenzymes; Oligonucleotides, Antisense; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Involvement of protein kinase C in the inhibition of nitric oxide production from murine microglial cells by glucocorticoid.
Topics: Alkaloids; Animals; Animals, Newborn; Cells, Cultured; Dexamethasone; Interferon-gamma; Kinetics; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Microglia; Nitric Oxide; Polymyxin B; Protein Kinase C; Recombinant Proteins; Salmonella enteritidis; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electrophysiology; GTP-Binding Proteins; Guanosine Diphosphate; Guinea Pigs; Hippocampus; Interleukin-1; Isoquinolines; Neurons; Pertussis Toxin; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Involvement of protein kinase C and protein tyrosine kinase pathways in tumor necrosis factor-alpha-induced clustering of ovarian theca-interstitial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstenedione; Animals; Benzophenanthridines; Benzylidene Compounds; Catechols; Cell Adhesion; Diglycerides; Enzyme Activation; Female; Hypophysectomy; Isoquinolines; Luteinizing Hormone; Nitriles; Phenanthridines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Theca Cells; Tumor Necrosis Factor-alpha; Tyrphostins | 1993 |
The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Carrier Proteins; Cell Hypoxia; Cells, Cultured; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gene Expression Regulation; Heat-Shock Proteins; Humans; Isoquinolines; Molecular Chaperones; Molecular Sequence Data; Oligodeoxyribonucleotides; Oxygen; Piperazines; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effect of a benzylidene derivative, novel antirheumatic agent, on the production of tissue inhibitor of metalloproteinases.
Topics: Alkaloids; Animals; Benzaldehydes; Cartilage; Catechols; Cattle; Cells, Cultured; Culture Media; Drug Synergism; Humans; Interleukin-1; Nasal Septum; Protein Biosynthesis; Protein Kinase C; Proteoglycans; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2 | 1994 |
Modulation of protein kinase C alters hemodynamics and metabolism in the isolated liver in fed and fasted rats.
Topics: Alkaloids; Animals; Enzyme Activation; Fasting; Food; Hemodynamics; In Vitro Techniques; Liver; Liver Circulation; Male; Organ Size; Perfusion; Phorbol Esters; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes.
Topics: Alkaloids; Cell Movement; Diglycerides; Humans; Isoenzymes; Melanoma; Neoplasm Invasiveness; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Preconditioning protects ischemic rabbit heart by protein kinase C activation.
Topics: Alkaloids; Animals; Diglycerides; Enzyme Activation; Female; Male; Myocardial Ischemia; Myocardial Stunning; Myocardium; Polymyxin B; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Regulation of parathyroid hormone gene expression and peptide secretion in human parathyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Alkaloids; Base Sequence; Blotting, Northern; Calcium; Cell Division; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hyperparathyroidism; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes.
Topics: Alkaloids; Amino Acid Sequence; Bryostatins; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Enzyme Induction; Epidermal Cells; Etretinate; Humans; Keratinocytes; Lactones; Macrolides; Molecular Sequence Data; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Modulation of the Na-H antiport by insulin: interplay between protein kinase C, tyrosine kinase, and protein phosphatases.
Topics: Alkaloids; Animals; Ethers, Cyclic; Insulin; Male; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes.
Topics: Alkaloids; Animals; Carrier Proteins; Erythrocytes; K Cl- Cotransporters; Magnesium; Marine Toxins; Osmolar Concentration; Oxazoles; Oxidation-Reduction; Phosphoprotein Phosphatases; Potassium; Protein Kinase Inhibitors; Sheep; Staurosporine; Symporters; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line.
Topics: Alkaloids; Biological Transport; Carrier Proteins; Cell Division; Colonic Neoplasms; Dipeptides; Diterpenes; Humans; Hydrogen; Kinetics; Protein Kinase C; Sodium; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Inhibition of procoagulant activity of human monocytes by chenodeoxycholic acid: involvement of protein kinase C.
Topics: Alkaloids; Blood Coagulation; Bucladesine; Chenodeoxycholic Acid; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Humans; Monocytes; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
The renal basolateral transport system for organic anions: properties of the regulation mechanism.
Topics: Alkaloids; Animals; Anions; Diglycerides; Enzyme Activation; Female; In Vitro Techniques; Inositol; Ion Transport; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effects of endothelin on rat renal proximal tubule Na(+)-Pi cotransport and Na+/H+ exchange.
Topics: Alkaloids; Animals; Carrier Proteins; Endothelins; Kidney Tubules, Proximal; Male; Microvilli; Parathyroid Hormone; Peptide Fragments; Pertussis Toxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sodium-Phosphate Cotransporter Proteins; Staurosporine; Symporters; Teriparatide; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Protein kinase C-dependent and -independent pathways mediate epidermal growth factor (EGF) effects in human endometrial adenocarcinoma cell line KLE.
Topics: Adenocarcinoma; Alkaloids; Animals; Cell Division; Dose-Response Relationship, Drug; Endometrial Neoplasms; Epidermal Growth Factor; Female; Humans; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1994 |
Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells.
Topics: Alkaloids; Amino Acid Sequence; Calcimycin; Cell Line; Glutathione Transferase; Humans; Leukotriene A4; Leukotriene B4; Leukotriene C4; Leukotriene D4; Molecular Sequence Data; Neutrophils; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Animals; Calcium; Calmodulin; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Neurons; Protein Kinase C; Rats; Receptors, Serotonin; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C inhibitors enhance differentiation of rat adipocyte precursor cells in serum-free culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Glycerolphosphate Dehydrogenase; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures.
Topics: Alkaloids; Animals; Becaplermin; Blotting, Northern; Bone and Bones; Cells, Cultured; Culture Media; Cycloheximide; Gene Expression; Kinetics; Osteoblasts; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Signal transduction in avian granulosa cells: effects of protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Chickens; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Female; Granulosa Cells; Inositol Phosphates; Isoquinolines; Piperazines; Progesterone; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85 alpha subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Platelets; Catechols; Enzyme Activation; Humans; Isoquinolines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Tyrphostins | 1994 |
Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Fibroblasts; Hydrogen Peroxide; Hydrolysis; Kinetics; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Sphingosine; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1994 |
Regulation of 92-kD gelatinase release in HL-60 leukemia cells: tumor necrosis factor-alpha as an autocrine stimulus for basal- and phorbol ester-induced secretion.
Topics: Alkaloids; Dexamethasone; Ditiocarb; Gelatinases; Humans; Leukemia, Promyelocytic, Acute; Molecular Weight; Pentoxifylline; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Altered protein kinase C regulation of phosphoinositide-coupled receptors in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Alkaloids; Animals; Aorta; Desoxycorticosterone; Hypertension; Male; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reference Values; Sodium Chloride; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Modulation of bradykinin-induced calcium signals by oxidative stress in PC12 cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Antioxidants; Bradykinin; Calcium; Cyclic AMP; Cyclic GMP; Free Radical Scavengers; Hydrogen Peroxide; Inositol 1,4,5-Trisphosphate; Kinetics; Nickel; PC12 Cells; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors | 1993 |
Thyrotropin stimulates invasion and growth of follicular thyroid cancer cells via PKC- rather than PKA-activation.
Topics: Alkaloids; Cell Division; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Humans; Neoplasm Invasiveness; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Decrease in the phosphotyrosine phosphatase activity in the plasma membrane of human neutrophils on stimulation by phorbol 12-myristate 13-acetate.
Topics: Alkaloids; Cell Membrane; Down-Regulation; Humans; Neutrophils; Protein Tyrosine Phosphatases; Proteins; Staurosporine; Subcellular Fractions; Substrate Specificity; Tetradecanoylphorbol Acetate; Trypsin | 1993 |
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Eicosanoids; Fatty Acids; Isoenzymes; Kinetics; Leukotriene C4; Macrophages, Peritoneal; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Inhibition and down-regulation of protein kinase C in cultured atrial myocytes: effects on distribution of specific granules and secretion of atrial natriuretic peptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cells, Cultured; Culture Media; Cycloheximide; Cytoplasmic Granules; Down-Regulation; Fluorescent Antibody Technique; Isoquinolines; Microscopy, Electron; Microtubules; Myocardium; Piperazines; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells.
Topics: Aldehydes; Alkaloids; Animals; Calcium; Cattle; Cell Death; Cell Membrane; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Glycerophospholipids; Lipid Peroxidation; Phosphates; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Modulators of the protein kinase C system influence biliary excretion of cationic drugs.
Topics: Alkaloids; Animals; Bile; Biological Transport, Active; Carrier Proteins; Cations; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Glucagon; In Vitro Techniques; Liver; Male; Perfusion; Protein Kinase C; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization.
Topics: Alkaloids; Amino Acid Sequence; Animals; Antigens; Cells, Cultured; Complement C5a; Humans; Kinetics; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
1,25-Dihydroxyvitamin D3 and macrophage colony-stimulating factor-1 synergistically phosphorylate talin.
Topics: Alkaloids; Animals; Calcitriol; Cell Line; Drug Synergism; Genistein; Isoflavones; L Cells; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Talin; Tetradecanoylphorbol Acetate | 1993 |
ATP-induced secretion in PC12 cells and photoaffinity labeling of receptors.
Topics: Adenosine Triphosphate; Affinity Labels; Alkaloids; Animals; Kinetics; Magnesium; Norepinephrine; PC12 Cells; Protein Kinase C; Receptors, Purinergic P1; Ribonucleotides; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia.
Topics: Alkaloids; Animals; Arachidonic Acid; Carbon Monoxide; Endotoxins; Fatty Acids, Nonesterified; Kupffer Cells; Lipoxygenase Inhibitors; Liver; Male; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1993 |
Reciprocal effects of the protein kinase C inhibitors staurosporine and H-7 on the regulation of glycogen synthase and phosphorylase in the primary culture of hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Glycogen; Glycogen Synthase; Isoquinolines; Liver; Male; Phosphorylases; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 1993 |
Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C.
Topics: Adenocarcinoma; Alkaloids; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Colonic Neoplasms; Enzyme Activation; Glycerides; Humans; Kinetics; Mannitol; Membrane Potentials; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Regulation of interleukin-6 (IL-6) expression: evidence for a tissue-specific role of protein kinase C.
Topics: Alkaloids; Base Sequence; Calcimycin; Carcinoma, Squamous Cell; DNA-Binding Proteins; Gene Expression Regulation; Interleukin-1; Interleukin-6; Laryngeal Neoplasms; Lipopolysaccharides; Molecular Sequence Data; Monocytes; NF-kappa B; Organ Specificity; Polymerase Chain Reaction; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1993 |
Transient exposure of human eosinophils to the protein kinase C inhibitors CGP39-360, CGP41-251, and CGP44-800 leads to priming of the respiratory burst induced by opsonized particles.
Topics: Alkaloids; Calcium; Enzyme Inhibitors; Eosinophils; Humans; Opsonin Proteins; Organic Chemicals; Platelet Activating Factor; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Animals; Blotting, Northern; Calcium; Cell Division; Enzyme Activation; Estradiol; Homeostasis; Isoquinolines; Kinetics; Osteoblasts; Osteosarcoma; Piperazines; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Alkaloids; Animals; Cell Membrane; Cell Movement; Collagen; Drug Combinations; Glycoproteins; Humans; Laminin; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Protein Kinase C; Proteoglycans; Rectal Neoplasms; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.
Topics: 3T3 Cells; Adenovirus E3 Proteins; Adenoviruses, Human; Alkaloids; Animals; Base Sequence; Cell Line; DNA; Down-Regulation; ErbB Receptors; Humans; Mice; Molecular Sequence Data; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1993 |
Cytosolic calcium homeostasis in bovine parathyroid cells and its modulation by protein kinase C.
Topics: Alkaloids; Animals; Barium; Calcium; Cations, Divalent; Cattle; Cytosol; Homeostasis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ion Transport; Parathyroid Glands; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C modulates hormone secretion regulated by extracellular polycations in bovine parathyroid cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcium; Cations; Cattle; Extracellular Space; Homeostasis; In Vitro Techniques; Isoproterenol; Parathyroid Glands; Parathyroid Hormone; Polyamines; Polyelectrolytes; Polymers; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Enhancement of A23187-induced arachidonic acid liberation by vasopressin is sensitive to genistein in rabbit platelets.
Topics: Acetophenones; Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Drug Synergism; Epinephrine; Genistein; Isoflavones; Phospholipases A; Phospholipases A2; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
The mechanism of bradykinin-induced arachidonic acid release in osteoblast-like MC3T3-E1 cells phospholipase A2 activation by bradykinin and its regulation by protein kinase C and calcium.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Down-Regulation; Mice; Osteoblasts; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Regulation of the endothelin-1 transmembrane signaling pathway: the potential role of agonist-induced desensitization in the coronary artery of the rapid ventricular pacing-overdrive dog model of heart failure.
Topics: Alkaloids; Animals; Arteries; Coronary Vessels; Disease Models, Animal; Dogs; Endothelins; Heart Failure; In Vitro Techniques; Inositol Phosphates; Phosphatidylinositols; Protein Kinase C; Radioimmunoassay; Receptors, Endothelin; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor.
Topics: Alkaloids; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cells, Cultured; Dactinomycin; Heart Ventricles; Kinetics; Myocardium; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1993 |
Positive regulation by protein kinase C of slow Na current in Xenopus oocytes.
Topics: Alkaloids; Animals; Diglycerides; Enzyme Activation; Female; Membrane Potentials; Oocytes; Phorbol Esters; Protein Kinase C; Sodium Channels; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Tetrodotoxin; Xenopus laevis | 1993 |
Exogenous arachidonic acid inactivates protein kinase C in mouse pancreatic islets.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cytosol; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Mice; Mice, Inbred Strains; Phosphatidylserines; Phosphorylation; Protein Kinase C; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C regulates IL-8 and fMLP induced cytoplasmic Ca2+ increase in human granulocytes by receptor modulation measurements by flow cytometry.
Topics: Alkaloids; Aniline Compounds; Calcium; Cytoplasm; Diglycerides; Flow Cytometry; Fluorescent Dyes; Granulocytes; Humans; In Vitro Techniques; Interleukin-8; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Xanthenes | 1993 |
Involvement of protein kinase C in the interleukin 1 alpha-induced gene expression of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases (TIMP-1) in human uterine cervical fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Collagen; Dinoprostone; Down-Regulation; Extracellular Matrix; Female; Fibroblasts; Gene Expression Regulation; Glycoproteins; Guinea Pigs; Humans; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Precursors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Uterus | 1993 |
Effect of protein kinase inhibitors on IL-8/NAP-1 release from human umbilical vein endothelial cells.
Topics: Alkaloids; Benzoquinones; Carbazoles; Cells, Cultured; Endothelium, Vascular; Humans; Indoles; Interleukin-1; Interleukin-8; Lactams, Macrocyclic; Protein Kinase Inhibitors; Pyrroles; Quinones; Recombinant Proteins; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins | 1993 |
Activin modulates the intracellular signaling system activated by gonadotropin-releasing hormone: dual effect on calcium messenger system and protein kinase-C pathway.
Topics: Activins; Alkaloids; Animals; Calcimycin; Calcium; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Inhibins; Intracellular Membranes; Luteinizing Hormone; Marine Toxins; Oxocins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Phorbol ester enhances activation of adenylate cyclase in bovine aortic endothelial cells.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Alkaloids; Analysis of Variance; Animals; Aorta; Bradykinin; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Phosphorylation; Protein Kinase C; Receptors, Adrenergic, beta; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Intracellular mechanism of Pb(2+)-induced norepinephrine release from bovine chromaffin cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Adrenal Medulla; Alkaloids; Animals; Calcium; Calmodulin; Cattle; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Imidazoles; Kinetics; L-Lactate Dehydrogenase; Lead; Norepinephrine; Protein Kinase C; Spectrophotometry, Atomic; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Ni2+ impairs thrombin-induced signal transduction by acting on the agonist and/or receptor in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Cell Membrane; Cytosol; Fura-2; Humans; In Vitro Techniques; Kinetics; Nickel; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Thrombin; Signal Transduction; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils.
Topics: Acetophenones; Alkaloids; Arachidonic Acid; Biological Transport; Cell Membrane; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Opsonin Proteins; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1994 |
Protein kinase C activation facilitates memory retention in rats.
Topics: Alkaloids; Animals; Avoidance Learning; Enzyme Activation; Male; Motor Activity; Phosphorylation; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Retention, Psychology; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
The role of cytosolic Ca2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Ethers, Cyclic; Glycerophospholipids; Isoquinolines; Liver; Male; Okadaic Acid; Phosphatidic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasopressins | 1994 |
Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoenzymes; Isoquinolines; Kinetics; Lysophospholipids; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Inositol phosphate-diacylglycerol signaling pathway in regulation of intraocular pressure.
Topics: Alkaloids; Animals; Aqueous Humor; Calcimycin; Diglycerides; Inositol Phosphates; Intraocular Pressure; Protein Kinase C; Rabbits; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate.
Topics: Alkaloids; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Enzyme Inhibitors; Ethers, Cyclic; Genistein; In Vitro Techniques; Isoflavones; Kupffer Cells; Lipopolysaccharides; Male; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Vanadates | 1994 |
The requirement of p47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Proteins; Cell Membrane; Cytosol; Enzyme Activation; Humans; Ionomycin; Isoquinolines; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Differential effects of phorbol myristate acetate and dexamethasone on protein kinase C activity and eicosanoids production in cultured rat astrocytes.
Topics: Alkaloids; Animals; Astrocytes; Biomarkers; Cells, Cultured; Colforsin; Dexamethasone; Dinoprostone; Eicosanoids; Female; Fluorescent Antibody Technique; Neuroglia; Pregnancy; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Effects of phorbol ester on gap junctions of neonatal rat heart cells.
Topics: Alkaloids; Animals; Animals, Newborn; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Diglycerides; Electric Conductivity; Heart Ventricles; Intercellular Junctions; Kinetics; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mucin secretion by T84 cells: stimulation by PKC, Ca2+, and a protein kinase activated by Ca2+ ionophore.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium; Colonic Neoplasms; Culture Media; Down-Regulation; Egtazic Acid; Humans; Mucins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Changes in proteoglycan core protein (PCP) mRNA levels during HL-60 cell differentiation.
Topics: Aggrecans; Alkaloids; Blotting, Northern; Cell Differentiation; Dimethyl Sulfoxide; Extracellular Matrix Proteins; Gene Expression; Genes, myc; Glycoproteins; Granulocytes; Humans; Kinetics; Lectins, C-Type; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Protein Kinase C; Proteoglycans; RNA, Messenger; RNA, Ribosomal, 18S; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amyloid beta-Protein Precursor; Animals; Cell Line; Glioma; Humans; Isoquinolines; Kinetics; Molecular Weight; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells.
Topics: Adenosine Diphosphate Ribose; Alkaloids; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; Calcium; Cell Line; Humans; Mice; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Respiratory Burst; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tetraspanin 25 | 1993 |
Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Alkaloids; Amiloride; Animals; Carbazoles; Dose-Response Relationship, Drug; Furosemide; Guinea Pigs; Indoles; Isometric Contraction; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Piperazines; Protein Kinase C; Respiratory Muscles; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1993 |
Modulation of activin A action and specificity in the rat gonadotrope by protein kinase C.
Topics: Activins; Alkaloids; Animals; Calcimycin; Dimethyl Sulfoxide; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Inhibins; Kinetics; Luteinizing Hormone; Pituitary Gland; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH-3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolysis; Indoles; Maleimides; Mice; Mitogens; Phosphatidic Acids; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Insulin stimulates the polymorphonuclear leukocyte chemokinesis.
Topics: Adult; Alkaloids; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Female; Humans; Insulin; Male; Neutrophils; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured | 1993 |
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulation of astrocyte proliferation by prostaglandin E2 and the alpha subtype of protein kinase C.
Topics: Alkaloids; Animals; Astrocytes; Cell Division; Cells, Cultured; Dinoprostone; Enzyme Activation; Indomethacin; Lipopolysaccharides; Mice; Mice, Inbred ICR; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Modulation by protein kinase C of arachidonic acid release from permeabilised myometrial cells of guinea pig uterus.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Inositol Phosphates; Myometrium; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
Control of HLA-DR antigen expression by gamma-interferon: separate signal transduction mechanisms in malignant and nonmalignant human thyroid cells.
Topics: Alkaloids; Calcimycin; Carcinoma; Cells, Cultured; Dose-Response Relationship, Drug; Drug Administration Schedule; Goiter; HLA-DR Antigens; Humans; Interferon-gamma; Isoquinolines; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1993 |
12-O-tetradecanoylphorbol-13-acetate and staurosporine induce increased retinoblastoma tumor suppressor gene expression with megakaryocytic differentiation of leukemic cells.
Topics: Alkaloids; Cell Cycle; Cell Differentiation; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Leukemic; Genes, Retinoblastoma; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Phosphorylation; Protein Kinase C; Retinoblastoma Protein; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Interferon-alpha (IFN alpha) induces a cytolytic mechanism in ovarian carcinoma cells through a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Emetine; Female; Humans; Interferon alpha-2; Interferon-alpha; Isoquinolines; Ovarian Neoplasms; Piperazines; Protein Biosynthesis; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
2-Hydroxypropyl-beta-cyclodextrin enhances phorbol ester effects on glucose transport and/or protein kinase C-beta translocation to the plasma membrane in rat adipocytes and soleus muscles.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; 3-O-Methylglucose; Adipose Tissue; Alkaloids; Animals; beta-Cyclodextrins; Cell Membrane; Cyclodextrins; Cytosol; Deoxyglucose; Epididymis; Insulin; Isoenzymes; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Muscles; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters.
Topics: 3T3 Cells; Alkaloids; Animals; Cell Transformation, Viral; Enzyme Activation; Mice; Oncogene Protein pp60(v-src); Phospholipase D; Protein Kinase C; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1993 |
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation.
Topics: Alkaloids; Amino Alcohols; Arachidonic Acid; Enzyme Activation; Humans; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Onium Compounds; Phosphoproteins; Phosphorylation; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Cyclic adenosine 3',5'-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis.
Topics: Adenylyl Cyclases; Alkaloids; Bucladesine; Cell Division; Colforsin; Cyclic AMP; Humans; Interleukin-1; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cytochrome b Group; Dexamethasone; Drug Synergism; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-8; Isoquinolines; NADPH Oxidases; Neutrophils; Piperazines; RNA, Messenger; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Type-specific stimulation of adenylylcyclase by protein kinase C.
Topics: Adenylyl Cyclases; Alkaloids; Cells, Cultured; Cyclic AMP; DNA; Enzyme Activation; Humans; Isoenzymes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Monoclonal antibody 8A2-induced retraction appears to be mediated by protein phosphorylation in goldfish retinal ganglion cell axons.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Axons; Calcium; Cyclic AMP; Ethers, Cyclic; Goldfish; Nerve Regeneration; Okadaic Acid; Organ Culture Techniques; Phorbol Esters; Phorbols; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Retinal Ganglion Cells; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Control of myogenic factor genes by the membrane depolarization/protein kinase C cascade in chick skeletal muscle.
Topics: Alkaloids; Animals; Cell Membrane; Chickens; Electric Stimulation; Gene Expression Regulation; Muscle Denervation; Muscle Proteins; Muscles; Myogenin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1993 |
Parathyroid hormone raises cytosolic calcium in pancreatic islets: study on mechanisms.
Topics: Alkaloids; Animals; Bucladesine; Calcium; Cytosol; GTP-Binding Proteins; In Vitro Techniques; Islets of Langerhans; Male; Parathyroid Hormone; Peptide Fragments; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Teriparatide; Tetradecanoylphorbol Acetate; Verapamil | 1993 |
Desensitization of acetylcholine induced inositol 1,4,5-trisphosphate formation in neuroblastoma SH-SY5Y cells following repetitive acetylcholine stimulations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Alkaloids; Animals; Down-Regulation; Enzyme Activation; Humans; Inosine Triphosphate; Isoquinolines; Neuroblastoma; PC12 Cells; Phosphatidylinositols; Piperazines; Protein Kinase C; Second Messenger Systems; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector.
Topics: Alkaloids; Animals; Benzophenanthridines; Bucladesine; Diglycerides; Exocytosis; In Vitro Techniques; Lacrimal Apparatus; Male; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1993 |
Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alkaloids; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Epithelium; Indomethacin; Models, Biological; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1993 |
Effects of protein kinase C activation on norepinephrine-induced phosphatidylinositide hydrolysis in intact rat aorta.
Topics: Alkaloids; Animals; Aorta, Thoracic; Dinoprost; Enzyme Activation; Hydrolysis; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved sel
Topics: Alkaloids; Bucladesine; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipase D; Protein Kinase C; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Cross-talk between Ca2+ influx and phosphoinositide hydrolysis by extracellular adenosine triphosphate in rat PC12 pheochromocytoma cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcium; Calcium Radioisotopes; Hydrolysis; Kinetics; Nifedipine; PC12 Cells; Pertussis Toxin; Phorbol Esters; Phosphatidylinositols; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
The potentiation by TNF-alpha and PMA of Fc receptor-mediated phagocytosis in neutrophils is independent of reactive oxygen metabolites produced by NADPH oxidase and of protein kinase C.
Topics: Alkaloids; Dose-Response Relationship, Drug; Humans; Immunoglobulin G; In Vitro Techniques; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Onium Compounds; Phagocytosis; Protein Kinase C; Receptors, Fc; Staurosporine; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Desensitization of calcium messenger system in parathyroid hormone-stimulated opossum kidney cells.
Topics: Alkaloids; Animals; Calcium; Clone Cells; Cyclic AMP; Dose-Response Relationship, Drug; Electrophysiology; Intracellular Membranes; Kidney; Opossums; Osmolar Concentration; Parathyroid Hormone; Protein Kinase C; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Histamine; Humans; Peptide Fragments; Pertussis Toxin; Protein Kinase C; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Histamine H2; Staurosporine; Stimulation, Chemical; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.
Topics: Alkaloids; Animals; Cell Line; Collagenases; Dexamethasone; Endopeptidases; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Fibroblasts; Gelatinases; Interleukin-1; Keratinocytes; Mammary Neoplasms, Experimental; Molecular Weight; Mouth Mucosa; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1993 |
Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC.
Topics: Alkaloids; Amiloride; Animals; Carrier Proteins; Cricetinae; Culture Media, Serum-Free; Enzyme Activation; Fibroblasts; Hydrogen-Ion Concentration; Mice; Polylysine; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
The signal transduction pathway for VGF expression due to NGF is different from that due to bFGF in PC12h cell.
Topics: Alkaloids; Animals; Bucladesine; Colforsin; Deoxyadenosines; Fibroblast Growth Factor 2; Heparin; Molecular Weight; Nerve Growth Factors; PC12 Cells; Potassium Chloride; Protein Biosynthesis; Protein Kinase C; Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleosides | 1993 |
Insulin-like growth factor-II in human fetal adrenals: regulation by ACTH, protein kinase C and growth factors.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Alkaloids; Blotting, Northern; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Gene Expression; Gene Expression Regulation; Genes; Growth Substances; Humans; Insulin-Like Growth Factor II; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1993 |
Staurosporine inhibits protein kinases activated by Ca2+ and cyclic AMP in addition to inhibiting protein kinase C in rat islets of Langerhans.
Topics: Alkaloids; Animals; Calcium; Cell Membrane Permeability; Cyclic AMP; Enzyme Activation; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mastoparan stimulates insulin secretion from pancreatic beta-cells by effects at a late stage in the secretory pathway.
Topics: Adenosine Triphosphate; Alkaloids; Amino Acid Sequence; Animals; Calcium; Cell Membrane Permeability; Cyclic AMP; Enzyme Activation; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Insulin; Insulin Secretion; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Molecular Sequence Data; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thionucleotides; Wasp Venoms | 1993 |
Alkylcatechols regulate NGF gene expression in astroglial cells via both protein kinase C- and cAMP-independent mechanisms.
Topics: Alkaloids; Animals; Animals, Newborn; Astrocytes; Brain; Catechols; Cells, Cultured; Cyclic AMP; Drug Synergism; Enzyme Activation; Gene Expression; Kinetics; Mice; Nerve Growth Factors; Protein Kinase C; RNA Probes; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Role of protein kinase-C in the alpha 1-adrenoceptor-mediated responses of perfused rat liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Cell Membrane; Cytosol; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Liver; Male; Perfusion; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Activity of protein kinase C during the differentiation of chick limb bud mesenchymal cells.
Topics: Alkaloids; Animals; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; Contact Inhibition; Mesoderm; Morphogenesis; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Wings, Animal | 1993 |
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Topics: Adenocarcinoma; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Bucladesine; Cell Division; Colforsin; Enzyme Activation; Humans; Protein Kinase C; Staurosporine; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis.
Topics: Alkaloids; Cells, Cultured; Fluorometry; Humans; Isoelectric Focusing; Keratinocytes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Psoriasis; Reference Values; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Regulation of the 12-O-tetradecanoyl-phorbol-13-acetate-induced inhibition of intercellular communication.
Topics: Alkaloids; Animals; Cell Communication; Cell Line; Image Processing, Computer-Assisted; Isoquinolines; Liver; Microscopy, Fluorescence; Protein Kinase C; Pyrimidine Nucleosides; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1993 |
Role of protein kinase C in bradykinin-induced prostaglandin formation in osteoblasts.
Topics: Alkaloids; Animals; Bradykinin; Calcimycin; Cell Membrane; Cells, Cultured; Dinoprostone; Enzyme Activation; Hydrocortisone; Indomethacin; Mice; Osteoblasts; Phorbol 12,13-Dibutyrate; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium.
Topics: Alkaloids; Animals; Bradykinin; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Glycerophospholipids; In Vitro Techniques; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation.
Topics: Alkaloids; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Differentiation; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Papilloma; Protein Kinase C; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Regulation of fibronectin and laminin binding activity in cultured human lymphoblastic cell lines.
Topics: Alkaloids; Cell Adhesion; Fibronectins; Humans; Laminin; Receptors, Fibronectin; Receptors, Laminin; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1993 |
Neurite outgrowth and protein phosphorylation in chick embryonic sensory ganglia induced by a brief exposure to 12-O-tetradecanoylphorbol 13-acetate.
Topics: Alkaloids; Animals; Chick Embryo; Ganglia; Nerve Tissue Proteins; Neurites; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Comparison of phospholipase D activity in vasopressin- and phorbol ester-stimulated fibroblasts.
Topics: Alkaloids; Calcium; Cell Line; Enzyme Activation; Fibroblasts; Glycerol; Glycerophospholipids; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Phospholipase D; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Protection against apoptosis in chicken bursa cells by phorbol ester in vitro.
Topics: Alkaloids; Animals; Apoptosis; B-Lymphocytes; Bursa of Fabricius; Cells, Cultured; Chickens; DNA; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Enhancement of thyrotropin-stimulated iodide organification in porcine thyroid cells after protein kinase-C inhibition.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Glyceryl Ethers; Iodides; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1993 |
Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine.
Topics: Alkaloids; Biological Transport; Blood Platelets; Calcimycin; Calcium; Carrier Proteins; Complement Membrane Attack Complex; Cytoplasmic Granules; Exocytosis; Flow Cytometry; Fluorescence; Humans; Kinetics; Membrane Fusion; Membrane Proteins; Phosphatidylserines; Phospholipid Transfer Proteins; Phospholipids; Platelet Activation; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Role of protein kinase C and cytokines on the function and production of cytolytic granules in alpha CD3-activated killer-cell-mediated killing of tumor cells.
Topics: Alkaloids; Animals; Antibodies; Antibody-Dependent Cell Cytotoxicity; CD3 Complex; Cytokines; Cytoplasmic Granules; Cytotoxicity, Immunologic; Female; Granzymes; Immunotherapy, Adoptive; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Protein Kinase C; Serine Endopeptidases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Exposure of platelet fibrinogen receptors by zinc ions: role of protein kinase C.
Topics: Adenosine Diphosphate; Alkaloids; Blood Platelets; Drug Synergism; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Humans; In Vitro Techniques; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine; Zinc | 1993 |
Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway.
Topics: Alkaloids; Bryostatins; Cell Differentiation; Cellular Senescence; Gene Expression; Genes, fos; Humans; Lactones; Macrolides; Neuroblastoma; Neurons; Phenotype; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Mas; Staurosporine; Subcellular Fractions; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Fibroblast contraction of collagen gels requires activation of protein kinase C.
Topics: Alkaloids; Collagen; Enzyme Activation; Fibroblasts; Gels; Humans; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1993 |
Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells.
Topics: Alkaloids; Animals; Biological Transport; Cell Compartmentation; Cell Line; Cytosol; Deoxyglucose; Diglycerides; Down-Regulation; Glucose; Glucose Transporter Type 4; Hyperglycemia; Insulin; Membranes; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
12-O-tetradecanoylphorbol-13-acetate not only modulates proliferation rates, but also alters antigen expression and LAK-cell susceptibility of normal human melanocytes in vitro.
Topics: Alkaloids; Antigens; Cell Division; Cytotoxicity, Immunologic; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Melanocytes; Protein Kinase C; Reference Values; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner.
Topics: Alkaloids; Animals; beta-Adrenergic Receptor Kinases; Carbachol; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Kinetics; Male; Pancreas; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Agents that activate protein kinase C rescue sheep ileal Peyer's patch B cells from apoptosis.
Topics: Alkaloids; Animals; Antigens, Surface; Apoptosis; B-Lymphocytes; Calcimycin; Calcium; Cell Size; DNA Damage; Enzyme Activation; Female; Ileum; Male; Peyer's Patches; Protein Kinase C; Sheep; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Continuous monitoring of nitric oxide release from human umbilical vein endothelial cells.
Topics: Alkaloids; Arginine; Bradykinin; Cells, Cultured; Colforsin; Endothelium, Vascular; Enzyme Activation; Humans; Ionomycin; Kinetics; Nitric Oxide; Polarography; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins | 1993 |
Ectoprotein kinase activities on non-differentiated and differentiated U-937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Calcium; Carcinogens; Cell Differentiation; Cyclic AMP; Enzyme Inhibitors; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Oligopeptides; Phosphorylation; Phosvitin; Piperazines; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Phorbol ester regulation of opioid peptide gene expression in myocardial cells. Role of nuclear protein kinase.
Topics: Alkaloids; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Enzyme Inhibitors; Gene Expression; Heart Ventricles; Isoenzymes; Kinetics; Male; Myocardium; Phorbol Esters; Protein Kinase C; Protein Precursors; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
The activation and nuclear translocation of extracellular signal-regulated kinases (ERK-1 and -2) appear not to be required for elongation of neurites in PC12D cells.
Topics: Alkaloids; Animals; Biological Transport; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Enzyme Activation; Growth Substances; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurites; PC12 Cells; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
1,25-dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades.
Topics: Alkaloids; Calcitriol; Cell Differentiation; Enzyme Inhibitors; Genistein; Humans; Indoles; Isoflavones; Leukemia, Promyelocytic, Acute; Maleimides; Monocytes; Phagocytosis; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Phorbol ester (TPA)-induced differential modulation of cell surface antigens in human pluripotential leukemia (K-562) cell line: effects of protein kinase inhibitors with broad- and PKC selective inhibitory activity.
Topics: Alkaloids; Antigens, CD; CD59 Antigens; Humans; Intercellular Adhesion Molecule-1; Leukemia; Leukocyte Common Antigens; Lymphocyte Function-Associated Antigen-1; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
The relationship between protein kinase C subspecies and multidrug resistance in vincristine resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; CHO Cells; Choline; Cricetinae; Drug Resistance, Multiple; Indoles; Isoenzymes; Kinetics; Phospholipids; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vincristine | 1995 |
Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors.
Topics: Alkaloids; Animals; Bryostatins; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Lactones; Macrolides; Models, Biological; Neoplasm Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thioguanine | 1995 |
Inhibitory effect of phorbol ester on bradykinin-induced phosphoinositide hydrolysis and calcium mobilization in cultured canine tracheal smooth muscle cells.
Topics: Alkaloids; Animals; Bradykinin; Calcium; Cells, Cultured; Dogs; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Female; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Muscle, Smooth; Phorbol Esters; Phosphatidylinositols; Protein Kinase C; Receptors, Bradykinin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Activation of human endometrial phospholipase D by bradykinin.
Topics: Adult; Alkaloids; Bradykinin; Cells, Cultured; DNA; Drug Synergism; Endometrium; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Glycerophospholipids; Humans; Inositol Phosphates; Isoflavones; Kinetics; Middle Aged; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Stromal Cells; Tetradecanoylphorbol Acetate | 1995 |
Extracellular ATP causes of loss of L-selectin from human lymphocytes via occupancy of P2Z purinocepters.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Cells, Cultured; Down-Regulation; Humans; L-Selectin; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Magnesium; Protein Kinase C; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
GTPgammaS-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not tyrosine kinases.
Topics: Alkaloids; Benzylidene Compounds; Cell Membrane Permeability; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroquinones; In Vitro Techniques; Indoles; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nitriles; Phospholipase D; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1996 |
Species differences in the induction of time-dependent potentiation of insulin secretion.
Topics: Alkaloids; Animals; Carbachol; Drug Synergism; Enzyme Inhibitors; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Muscarinic Agonists; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Species Specificity; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 1996 |
The actions of prostaglandin E2 on potassium currents in rat tail artery vascular smooth muscle cells: regulation by protein kinase A and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Male; Muscle, Smooth, Vascular; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Tail; Tetradecanoylphorbol Acetate | 1996 |
Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells.
Topics: Adenylyl Cyclases; Alkaloids; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Insulin; Isoenzymes; Kidney; Molecular Sequence Data; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1996 |
Tamoxifen antagonizes proliferation and invasion of estrogen receptor-negative metastatic follicular thyroid cancer cells via protein kinase C.
Topics: Alkaloids; Antineoplastic Agents, Hormonal; Cell Division; Drug Interactions; Enzyme Inhibitors; Estrogen Antagonists; Humans; Lung Neoplasms; Neoplasm Invasiveness; Protein Kinase C; Receptors, Estrogen; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1996 |
Regulation of p21WAF1/CIP1 expression by p53-independent pathways.
Topics: Alkaloids; Blood; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Ethers, Cyclic; Gene Expression Regulation; Genes, p53; Humans; Okadaic Acid; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Differentiation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Sphingosine; Staurosporine; Suppression, Genetic; Tetradecanoylphorbol Acetate | 1996 |
Protein kinase C modulates natriuretic peptide receptors in astroglial cultures from rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Animals, Newborn; Astrocytes; Atrial Natriuretic Factor; Binding Sites; Brain Stem; Cells, Cultured; Colforsin; Cyclic GMP; Down-Regulation; Enzyme Inhibitors; Hypothalamus; Kinetics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa.
Topics: Alkaloids; Animals; Cells, Cultured; Cholera Toxin; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Gastric Fundus; Gastric Mucosa; Gastrins; Gene Expression; Histamine; Histidine Decarboxylase; Kinetics; Pertussis Toxin; Polymyxin B; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1996 |
Modulation by protein kinase C activation of rat brain delayed-rectifier K+ channel expressed in Xenopus oocytes.
Topics: Alkaloids; Animals; Base Sequence; Brain; Cell Membrane; Diglycerides; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Female; Kinetics; Membrane Potentials; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Naphthalenes; Oocytes; Patch-Clamp Techniques; Potassium Channels; Protein Kinase C; Protein Structure, Secondary; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Xenopus laevis | 1996 |
Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Calcium; Cell Division; Choline; Enzyme Inhibitors; GTP-Binding Proteins; Inositol Phosphates; Mice; Osteoblasts; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Propranolol; Protein Kinase C; Signal Transduction; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Interleukin-1beta activates protein kinase C zeta in renal mesangial cells. Potential role in prostaglandin E2 up-regulation.
Topics: Alkaloids; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cytosol; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Interleukin-1; Kinetics; Male; Molecular Sequence Data; Naphthalenes; NF-kappa B; Oligonucleotide Probes; Oligonucleotides, Antisense; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1996 |
Regulation of epithelial Na+ permeability by protein kinase C is tissue specific.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Amiloride; Animals; Benzophenanthridines; Biological Transport; Bufo marinus; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Organ Specificity; Phenanthridines; Piperazines; Protein Kinase C; Rana catesbeiana; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Urinary Bladder | 1996 |
Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells.
Topics: Alkaloids; Animals; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Enzyme Inhibitors; Interleukin-1; Interleukin-2; Kinetics; Mice; NF-kappa B; Protein Kinase C; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured | 1996 |
Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils.
Topics: Adrenal Glands; Alkaloids; Animals; Azepines; Calcium; Calcium Channel Blockers; Cattle; Chromaffin Granules; Enzyme Inhibitors; Imidazoles; Ion Transport; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Triazoles | 1996 |
Tyrosine kinase is involved in angiotensin II-stimulated phospholipase D activation in aortic smooth muscle cells: function of Ca2+ influx.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Choline; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Genistein; Inositol Phosphates; Ionophores; Isoflavones; Membrane Lipids; Muscle Proteins; Muscle, Smooth, Vascular; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Modulation of the stress-induced synthesis of stress proteins by a phorbol ester and okadaic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Arsenites; Blotting, Northern; Blotting, Western; Enzyme Activation; Ethers, Cyclic; Glioma; Heat-Shock Proteins; Okadaic Acid; Protein Kinase C; Rats; RNA, Messenger; Serine Proteinase Inhibitors; Staurosporine; Stimulation, Chemical; Stress, Physiological; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
GH inhibition of lipogenesis and stimulation of lipolysis in sheep adipose tissue: involvement of protein serine phosphorylation and dephosphorylation and phospholipase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyl-CoA Carboxylase; Adipose Tissue; Alkaloids; Animals; Bridged-Ring Compounds; Culture Techniques; Ethers, Cyclic; Glycerol; Growth Hormone; Isoquinolines; Lipid Metabolism; Lipids; Lipolysis; Male; Norbornanes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Sheep; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Type C Phospholipases | 1996 |
Pharmacological studies on mechanisms involved in Ca2+ oscillations in rat megakaryocytes.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Female; Indoles; Male; Megakaryocytes; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
GABA rho1 receptor: inhibition by protein kinase C activators.
Topics: Alkaloids; Animals; Cyclic AMP; Diterpenes; Electrophysiology; Enzyme Activation; GABA Antagonists; Protein Kinase C; Receptors, GABA; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection; Xenopus laevis | 1995 |
Flow cytometric investigation of neutrophil activation pathways by n-formyl-Met-Leu-Phe and phorbol myristate acetate.
Topics: Alkaloids; Antigens, CD; Calcium; Edetic Acid; Enzyme Inhibitors; Flow Cytometry; Humans; In Vitro Techniques; Ionophores; Light; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Scattering, Radiation; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Modulation of macrophage scavenger receptor transport by protein phosphorylation.
Topics: Animals; Blotting, Northern; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Lipoproteins, LDL; Macrophages, Peritoneal; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pinocytosis; Protein Binding; Protein Kinase C; Receptors, Immunologic; Receptors, Scavenger; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Effects of corticotropin-releasing hormone, lysine vasopressin, oxytocin, and angiotensin II on adrenocorticotropin secretion from porcine anterior pituitary cells.
Topics: Adrenocorticotropic Hormone; Alkaloids; Angiotensin II; Animals; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Synergism; Lypressin; Oxytocin; Pituitary Gland, Anterior; Protein Kinase C; Radioimmunoassay; Signal Transduction; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1996 |
Increased desensitization by picomolar phorbol ester of the endothelium-mediated effect of histamine in the perfused rat mesenteric bed.
Topics: Aging; Alkaloids; Animals; Carbachol; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Histamine; Male; Mesenteric Arteries; Norepinephrine; Parasympathomimetics; Perfusion; Protein Kinase C; Rats; Rats, Wistar; Receptors, Histamine H1; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Vasodilation | 1996 |
Protein phosphorylation in the blood-brain barrier. Possible presence of MARCKS in brain microvessels.
Topics: Alkaloids; Animals; Autoradiography; Blood-Brain Barrier; Brain; Capillaries; Cerebrovascular Circulation; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Molecular Weight; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Proteins; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Protein kinase C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells.
Topics: Alkaloids; Calcium; Calcium-Transporting ATPases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Ionomycin; Ionophores; Lanthanum; Leukemia; Naphthalenes; Phorbol Esters; Protein Kinase C; Sodium; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1995 |
Enhanced expression of GTP-binding proteins in differentiated U937 monocytic cells: possible involvement of tyrosine kinase and protein kinase C.
Topics: Alkaloids; Cell Differentiation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Humans; Isoflavones; Monocytes; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.
Topics: Animals; Antigens, CD; Bacterial Proteins; Cell Line; Cells, Cultured; Chlorocebus aethiops; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Haptoglobins; Hemolysin Proteins; Humans; Kinetics; Lipopolysaccharide Receptors; Macrophages; Monocytes; Receptors, Interleukin; Receptors, Interleukin-6; Recombinant Proteins; Signal Transduction; Staurosporine; Streptolysins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1996 |
Tumor necrosis factor alpha (TNFalpha) induces pro-matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1alpha antagonizes the inductive effect of TNFalpha.
Topics: Alkaloids; Cells, Cultured; Cervix Uteri; Collagenases; Enzyme Induction; Enzyme Inhibitors; Enzyme Precursors; Female; Fibroblasts; Humans; Interleukin-1; Matrix Metalloproteinase 9; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1996 |
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Feedback; Female; Kidney Tubules, Collecting; Male; Ouabain; Patch-Clamp Techniques; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Desensitization of 5HT2 receptors by protein kinase C activation in distal pulmonary vascular smooth muscle cells in culture.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Protein Kinase C; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.
Topics: Alkaloids; Base Sequence; Calcimycin; Cell Hypoxia; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; I-kappa B Proteins; Ionophores; Isoflavones; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Binding; Protein Kinase C; Protein Tyrosine Phosphatases; src-Family Kinases; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
HIV-1 gp41 binding to human T- and B-lymphocytes and monocytes is modulated by phorbol myristate acetate (PMA).
Topics: Adult; B-Lymphocytes; Cell Membrane; Enzyme Inhibitors; Flow Cytometry; HIV Envelope Protein gp41; Humans; Membrane Proteins; Molecular Weight; Monocytes; Protein Binding; Protein Kinase C; Receptors, Cell Surface; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1996 |
Interactions between signaling pathways in mediating GnRH-stimulated GTH release from goldfish pituitary cells: protein kinase C, but not cyclic AMP is an important mediator of GnRH-stimulated gonadotropin secretion in goldfish.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Arachidonic Acid; Calcium Channel Agonists; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Male; Microspheres; Naphthalenes; Pituitary Gland; Potassium; Protein Kinase C; Salmon; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Induction of apoptosis in MDA-231 cells by protein synthesis inhibitors is suppressed by multiple agents.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Cycloheximide; DNA; Epidermal Growth Factor; Female; Humans; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages.
Topics: Animals; Bordetella pertussis; Cytochrome c Group; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Immunization; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Ovalbumin; Peptide Fragments; Protein Kinase C; Receptors, Tachykinin; Staurosporine; Substance P; Superoxides; Tachykinins; Tetradecanoylphorbol Acetate | 1996 |
Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor.
Topics: Carcinogens; Cell Nucleus; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytosol; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Protein Kinase C; Receptors, Aryl Hydrocarbon; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1996 |
Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Clofibrate; Enzyme Inhibitors; Ethanolamine; Ethanolamines; Fibroblasts; Humans; Hypolipidemic Agents; Isoquinolines; Phosphatidylcholines; Phospholipids; Protein Kinase C; Skin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1996 |
Plasminogen activator inhibitor-1 regulation in cultured rat peritubular cells by basic fibroblast growth factor and transforming growth factor-alpha.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Fibroblast Growth Factor 2; Kidney Tubules; Plasminogen Activator Inhibitor 1; Protein Kinase C; Rats; Recombinant Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1996 |
Effects of staurosporine on the capacitative regulation of the state of the Ca2+ reserves in activated Jurkat T lymphocytes.
Topics: Antibodies, Monoclonal; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability; Chelating Agents; Computer Simulation; Econazole; Egtazic Acid; Enzyme Inhibitors; Fura-2; Humans; Jurkat Cells; Kinetics; Lymphocyte Activation; Models, Immunological; Nickel; Protein Kinase C; Receptors, Antigen, T-Cell, alpha-beta; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Serotonin-induced changes in L-leucine transport across rabbit jejunum.
Topics: Animals; Biological Transport; Diffusion; Enzyme Activation; Enzyme Inhibitors; Gallic Acid; Intestinal Absorption; Jejunum; Leucine; Male; Protein Kinase C; Rabbits; Serotonin; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1996 |
Fibrinogen promotes monocyte adhesion via a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Alkaloids; Cell Adhesion; Cells, Cultured; Fibrin; Fibrinogen; Humans; Isoquinolines; Monocytes; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Modulation of drug-induced apoptosis in a human B-lymphoma cell line (HT58).
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Apoptosis; Dexamethasone; DNA Damage; Dose-Response Relationship, Drug; Etoposide; Flow Cytometry; Humans; Immunoglobulin M; Lymphoma, B-Cell; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Ketoconazole and phorbol myristate acetate regulate osteoclast precursor fusion in primary murine marrow culture.
Topics: Acid Phosphatase; Animals; Antifungal Agents; Biomarkers, Tumor; Bone Marrow; Bone Marrow Cells; Cell Fusion; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Giant Cells; Isoenzymes; Ketoconazole; Mice; Osteoclasts; Staurosporine; Tartrate-Resistant Acid Phosphatase; Tetradecanoylphorbol Acetate | 1996 |
Gamma interferon induced increases in intracellular cathepsin B activity in PMA primed THP-1 cells are blocked by inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cathepsin B; Cytoplasm; Humans; Infant; Interferon-gamma; Leukemia, Monocytic, Acute; Phloretin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Induction of thiol recycling by protein kinase C: a potentially pro-oxidant pathway for low-density lipoprotein oxidation.
Topics: Alkaloids; Arteriosclerosis; Benzophenanthridines; Cell Line; Enzyme Inhibitors; Humans; Lipoproteins, LDL; Monocytes; Oxidants; Oxidation-Reduction; Phenanthridines; Protein Kinase C; Staurosporine; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate | 1996 |
Production of C-type natriuretic peptide in human aortic endothelial cells induced by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aorta; Base Sequence; Cells, Cultured; Diglycerides; Endothelium; Enzyme Activation; Enzyme Inhibitors; Humans; Natriuretic Peptide, C-Type; Protein Biosynthesis; Protein Kinase C; Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Function of Ca2+ in phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Calcium; Calcium Channel Blockers; Choline; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Imidazoles; Mice; Osteoblasts; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Potentiation by thyroxine of interferon-gamma-induced antiviral state requires PKA and PKC activities.
Topics: Animals; Calmodulin; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrenes; HeLa Cells; Humans; Indoles; Interferon-gamma; L Cells; Mice; Protein Kinase C; Pyrroles; Pyrrolidinones; Rhabdoviridae Infections; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thyroxine; Time Factors; Vesicular stomatitis Indiana virus; Viral Interference | 1996 |
Phosphorylation of myeloid-related proteins MRP-14 and MRP-8 during human neutrophil activation.
Topics: Antigens, Differentiation; Arachidonic Acid; Calcimycin; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Membrane; Cytochalasin B; Cytoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Regulation of hamster alpha 1B-adrenoceptors expressed in Chinese hamster ovary cells.
Topics: Adrenergic alpha-Agonists; Animals; CHO Cells; Cricetinae; Epinephrine; Phosphatidylinositols; Prazosin; Protein Kinase C; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity.
Topics: Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Naphthalenes; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
Topics: Amino Acid Sequence; Calcium; Chemotactic Factors; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Interleukin-8; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Protein kinase C activity and phosphoprotein pattern in stimulated alveolar macrophages.
Topics: Animals; Cattle; Cytosol; Electrophoresis, Gel, Two-Dimensional; In Vitro Techniques; Indoles; Macrophage Activation; Macrophages, Alveolar; Maleimides; Phosphoproteins; Protein Kinase C; Rats; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates | 1996 |
Protein kinase C modulates flow-initiated contraction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rabbits; Regional Blood Flow; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction | 1996 |
The activation of phospholipase D participates in the mitogenic action of arginine vasopressin in cultured rat glomerular mesangial cells.
Topics: 2,3-Diphosphoglycerate; Animals; Arginine Vasopressin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Diphosphoglyceric Acids; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Glycerophospholipids; Male; Mitogens; Naphthalenes; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Theileria parva sporozoite entry into bovine lymphocytes involves both parasite and host cell signal transduction processes.
Topics: Adenosine; Animals; Cattle; Down-Regulation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Isoflavones; Lymphocytes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Suramin; Tetradecanoylphorbol Acetate; Theileria parva; Trypanocidal Agents; Type C Phospholipases | 1996 |
Arachidonic acid metabolism in murine lymphoma cell sublines differing in radiation sensitivity.
Topics: Animals; Arachidonic Acid; Calcimycin; Cell Line; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Ionomycin; Lymphoma; Mice; Phospholipids; Prostaglandins; Radiation Tolerance; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; X-Rays | 1996 |
Evidence for G-protein-dependent and G-protein-independent activation of phospholipase D in lymphocytes.
Topics: Animals; Carbazoles; Catalysis; Cattle; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Indole Alkaloids; Lymphocytes; Phosphatidylethanolamines; Phospholipase D; Prostaglandins; Protein Kinase C; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Regulation of rat interstitial collagenase gene expression in growth cartilage and chondrocytes by vitamin D3, interleukin-1 beta, and okadaic acid.
Topics: Actins; Animals; Blotting, Northern; Carcinogens; Cartilage; Cells, Cultured; Cholecalciferol; Collagenases; Dactinomycin; DNA, Complementary; Electrophoresis, Agar Gel; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Interleukin-1; Male; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1996 |
ATP modulates sulfobromophthalein uptake in rat liver plasma membrane vesicles.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Membrane; Dose-Response Relationship, Drug; Female; Liver; Rats; Rats, Wistar; Staurosporine; Sulfobromophthalein; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 1996 |
A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin.
Topics: Animals; Animals, Newborn; Bradykinin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hot Temperature; Kinetics; Marine Toxins; Membrane Potentials; Neurons; Neurons, Afferent; Nociceptors; Oxazoles; Pain; Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.
Topics: Antibodies, Monoclonal; Apoptosis; Ceramides; fas Receptor; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Tyrosine kinase inhibition decreases Muc-1 expression in mouse epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Antibodies; Base Sequence; Cell Line; Cells, Cultured; Conserved Sequence; DNA Primers; Enzyme Inhibitors; Epithelium; Female; Gene Expression; Genistein; Isoflavones; Isoquinolines; Kinetics; Mammary Glands, Animal; Mice; Molecular Sequence Data; Mucin-1; Naphthalenes; Peptide Fragments; Polymerase Chain Reaction; Pregnancy; Protein Biosynthesis; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Uterus | 1997 |
Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production.
Topics: Blotting, Western; Cell Nucleus; Cells, Cultured; Cloning, Molecular; Cytosol; DNA-Binding Proteins; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Plasmids; Polymerase Chain Reaction; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection | 1997 |
Study of protein kinase C antagonists on cortical granule exocytosis and cell-cycle resumption in fertilized mouse eggs.
Topics: Alkaloids; Animals; Benzophenanthridines; Cell Cycle; Cell Degranulation; Enzyme Inhibitors; Exocytosis; Humans; Indoles; Male; Maleimides; Mice; Phenanthridines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Zygote | 1997 |
Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Diglycerides; Enzyme Inhibitors; Fatty Acids; Gallic Acid; Glycerides; Guinea Pigs; Male; Neutrophils; Phosphatidic Acids; Propranolol; Serum Albumin, Bovine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triglycerides | 1997 |
Fluorescence depolarization as an early measure of T lymphocyte stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Concanavalin A; Cytoplasm; Enzyme Inhibitors; Fluoresceins; Fluorescence Polarization; Humans; Lymphocyte Activation; Lymphocyte Count; Phosphatidylinositols; Phytohemagglutinins; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Phospholipase D hydrolysis of plasmalogen and diacyl ethanolamine phosphoglycerides by protein kinase C dependent and independent mechanisms.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Glioma; Hydrolysis; Kinetics; Phosphatidylethanolamines; Phospholipase D; Plasmalogens; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Functional properties of cultured endothelial cells derived from large microvessels of human brain.
Topics: Amiloride; Carrier Proteins; Cell Division; Cells, Cultured; Cerebrovascular Circulation; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Microcirculation; Ouabain; Potassium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine | 1997 |
Thrombin inhibits atrial natriuretic peptide receptor activity in cultured bovine endothelial cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Aorta; Atrial Natriuretic Factor; Cattle; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Atrial Natriuretic Factor; Receptors, Thrombin; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors | 1997 |
Protein kinase C involvement in the resting and interferon-gamma-induced K+ channel profile of microglial cells.
Topics: Animals; Animals, Newborn; Carcinogens; Drug Synergism; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; Interferon-gamma; Microglia; Potassium Channels; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1997 |
Involvement of protein kinase C in nerve growth factor- and K-252a-stimulated calcium uptake into PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Agonists; Carbazoles; Carcinogens; Enzyme Inhibitors; Indole Alkaloids; Indoles; Isoenzymes; Naphthalenes; Nerve Growth Factors; PC12 Cells; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Tumor necrosis factor-alpha regulates plasminogen activator inhibitor-1 in rat testicular peritubular cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Isoflavones; Male; Plasminogen Activator Inhibitor 1; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Staurosporine; Testis; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.
Topics: Adenovirus E1B Proteins; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Cycle; Cell Line; Cell Survival; Cycloheximide; Cyclosporine; Dexamethasone; Gamma Rays; Humans; Interleukin-3; Jurkat Cells; Kinetics; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
[Modulation with phorbol myristate acetate and staurosporine of interleukin 2- induced proliferation and nonspecific cytotoxicity of rat lymphocytes].
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; Cytotoxicity, Immunologic; Interleukin-2; Lymphocyte Activation; Lymphocytes; Male; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Calcium; Carcinogens; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fetus; Gene Expression; Glutamic Acid; Kainic Acid; Membrane Proteins; N-Methylaspartate; Naphthalenes; Neurons; Phenanthridines; Potassium Chloride; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Prostaglandin F2alpha stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells.
Topics: Animals; Cell Line; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Interleukin-6; Mice; Naphthalenes; Osteoblasts; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Phosphatidylinositol-3-kinase pathway is stimulated by fungal lipid containing cocoa butter equivalents (CBE) in FMet-Leu-Phe (FMLP)- and phorbolester (PMA)-challenged human neutrophils.
Topics: Cacao; Enzyme Inhibitors; Fungi; Humans; In Vitro Techniques; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1996 |
Contribution of PKC to beta-hexosaminidase-induced airway smooth muscle proliferation.
Topics: Animals; beta-N-Acetylhexosaminidases; Cattle; Cell Count; Cell Division; Diacylglycerol Kinase; Enzyme Inhibitors; Hexosaminidase A; Insulin; Muscle, Smooth; Naphthalenes; Phenylisopropyladenosine; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Thymidine; Trachea | 1997 |
Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation.
Topics: Animals; Arachidonic Acid; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inositol 1,4,5-Trisphosphate; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Regulation of luminol-dependent chemiluminescence and degranulation by bovine neutrophils stimulated with opsonized zymosan.
Topics: Adrenergic beta-Antagonists; Animals; Cattle; Cell Degranulation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Isoflavones; Luminescent Measurements; Luminol; Neutrophils; Pertussis Toxin; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Zymosan | 1996 |
Differential regulation of natriuretic peptide receptors on ciliary body epithelial cells.
Topics: Animals; Atrial Natriuretic Factor; Binding, Competitive; Carbachol; Cells, Cultured; Ciliary Body; Cyclic GMP; Down-Regulation; Epithelial Cells; Epithelium; Fetus; Guanylate Cyclase; Histamine; Humans; Kinetics; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Protein Kinase C; Proteins; Rabbits; Receptors, Atrial Natriuretic Factor; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1997 |
High glucose level inhibits capacitative Ca2+ influx in cultured rat mesangial cells by a protein kinase C-dependent mechanism.
Topics: Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Diabetes Mellitus; Enzyme Activation; Fura-2; Glomerular Mesangium; Glucose; Models, Biological; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils.
Topics: Adenylyl Cyclases; Electrochemistry; Enzyme Activation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Humans; Hydrogen Peroxide; Isoflavones; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Pertussis Toxin; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1997 |
CSF-1-induced and constitutive Il6 gene expression in mouse macrophages: evidence for PKC-dependent and -independent pathways.
Topics: Animals; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Indoles; Interleukin-6; Macrophage Colony-Stimulating Factor; Macrophages, Peritoneal; Male; Maleimides; Mice; Mice, Inbred C57BL; Mice, SCID; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Evidence that protein kinase C is involved in delta-aminolevulinate synthase expression in rat hepatocytes.
Topics: 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Diglycerides; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Naphthalenes; Phenobarbital; Protein Kinase C; Rats; RNA, Messenger; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Apoptosis; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Mice; Neoplasm Proteins; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution.
Topics: 1-Butanol; Actins; Adenocarcinoma; Animals; Butanols; Cell Adhesion; Cell Division; Enzyme Inhibitors; Genistein; Integrin beta1; Isoflavones; Mammary Neoplasms, Experimental; Mice; Microscopy, Fluorescence; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells.
Topics: Animals; Calcineurin; Calmodulin-Binding Proteins; Cell Line; Cell Nucleus; Cold Temperature; DNA-Binding Proteins; Enzyme Inhibitors; Immunosuppressive Agents; Indoles; Ionomycin; Ionophores; Kinetics; Lymphocyte Activation; Maleimides; Mice; NFATC Transcription Factors; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Staurosporine; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors | 1997 |
Mechanism of the morphological changes induced by staurosporine in rat osteoblasts.
Topics: Actin Cytoskeleton; Actins; Animals; Animals, Newborn; Calcimycin; Calcium; Carcinogens; Cells, Cultured; Cytochalasins; Diglycerides; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Microtubules; Osteoblasts; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Vimentin | 1997 |
The C terminus of the human C5a receptor (CD88) is required for normal ligand-dependent receptor internalization.
Topics: Animals; Antigens, CD; Cell Line; Complement C5a; DNA, Complementary; GTP-Binding Proteins; Humans; Iodine Radioisotopes; Kidney; Leukemia, Basophilic, Acute; Ligands; Mutagenesis, Site-Directed; Peptide Fragments; Pertussis Toxin; Protein Binding; Protein Kinase Inhibitors; Rats; Receptor, Anaphylatoxin C5a; Receptors, Complement; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Calcium; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Ibuprofen; Lipoprotein Lipase; Mutation; Phospholipases A; Phospholipases A2; Precipitin Tests; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Levels of DNA strand breaks and superoxide in phorbol ester-treated human granulocytes.
Topics: Chlorides; DNA Damage; Granulocytes; Humans; Kinetics; Respiratory Burst; Sodium Fluoride; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zinc Compounds | 1997 |
Induction of apoptosis through the PKC pathway in cultured dermal papilla fibroblasts.
Topics: Animals; Apoptosis; Biotin; Carcinogens; Cell Division; Cells, Cultured; DNA; DNA Fragmentation; Enzyme Inhibitors; Fetus; Fibroblasts; Flow Cytometry; Hair Follicle; Humans; Isoenzymes; Mice; Mice, Nude; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Scalp; Skin; Skin Transplantation; Staining and Labeling; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine; Tritium; Uracil Nucleotides | 1997 |
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
Topics: Animals; Cell Membrane; Cytosol; Drug Synergism; Enzyme Inhibitors; Indoles; Interleukin-1; Interleukin-2; Isoenzymes; Kinetics; Mice; NF-kappa B; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Time Factors; Tumor Cells, Cultured | 1997 |
Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation.
Topics: Alkaloids; Benzophenanthridines; Butyrates; Butyric Acid; Calcitriol; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Osteopontin; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tretinoin | 1997 |
Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: a correlation with cell polarity in HepG2 cells.
Topics: 4-Chloro-7-nitrobenzofurazan; Actin Cytoskeleton; Actins; Bile Canaliculi; Biological Transport; Carcinoma, Hepatocellular; Carrier Proteins; Cell Membrane; Cell Polarity; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Humans; Microfilament Proteins; Protein Kinase C; Sphingolipids; Sphingomyelins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Activation of host cell protein kinase C by enteropathogenic Escherichia coli.
Topics: Bacterial Toxins; Cyclic GMP; Diarrhea; Enterotoxins; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Humans; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Reorganization of the cortical actin cytoskeleton during maturation division in the Tubifex egg: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Calcimycin; Calcium; Cell Size; Chelating Agents; Cytoskeleton; Egtazic Acid; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Meiosis; Microinjections; Microscopy, Fluorescence; Oligochaeta; Oocytes; Protein Kinase C; Spectrophotometry; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Osmo-mechanically sensitive phosphatidylinositol signaling regulates a Ca2+ influx channel in renal epithelial cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbamates; Cells, Cultured; Dihydropyridines; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Nifedipine; Phenylcarbamates; Phosphatidylinositols; Rabbits; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Water-Electrolyte Balance | 1997 |
Ribonucleic acid expression of the CLA-1 gene, a human homolog to mouse high density lipoprotein receptor SR-BI, in human adrenal tumors and cultured adrenal cells.
Topics: Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Blotting, Northern; Bucladesine; CD36 Antigens; Cells, Cultured; Cushing Syndrome; Gene Expression; Humans; Hyperplasia; Membrane Proteins; Mice; Molecular Sequence Data; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Staurosporine differentiated human SH-SY5Y neuroblastoma cultures exhibit transient apoptosis and trophic factor independence.
Topics: Apoptosis; Aurintricarboxylic Acid; Calcium Channels; Cell Differentiation; Cell Survival; Electrophysiology; Enzyme Inhibitors; Humans; Ion Channel Gating; Nerve Growth Factors; Neuroblastoma; Neurons; Norepinephrine; Phenotype; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1997 |
Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues.
Topics: Alkaloids; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Indoles; Isoenzymes; Maleimides; Microscopy, Confocal; Models, Chemical; Protein Kinase C; Protein Kinase C-theta; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc Fingers | 1997 |
Role of protein kinases in the in vitro differentiation of human epidermal HaCaT cells.
Topics: Adenine; Cell Differentiation; Cell Line; Enzyme Inhibitors; Epidermal Cells; Epidermis; Genistein; Humans; Indoles; Isoenzymes; Isoflavones; Keratinocytes; Maleimides; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
A factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion.
Topics: Alkaloids; Animals; Benzophenanthridines; Binding Sites; Cell Line; Cysteine; Endosomes; Enzyme Inhibitors; Isoenzymes; Kinetics; Macrophages; Membrane Fusion; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Recombinant Fusion Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1997 |
Priming of mouse macrophages with the macrophage colony-stimulating factor (CSF-1) induces a variety of pathways that regulate expression of the interleukin 6 (Il6) and granulocyte-macrophage colony-stimulating factor (Csfgm) genes.
Topics: Animals; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Indoles; Interleukin-6; Kinetics; Macrophage Colony-Stimulating Factor; Macrophages, Peritoneal; Male; Maleimides; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Protein Kinase Inhibitors; Protein Kinases; Receptor, Macrophage Colony-Stimulating Factor; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cells, Cultured; Connexin 43; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gap Junctions; Myocardium; Patch-Clamp Techniques; Phosphorylation; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Opposite regulation of adenylyl cyclase by protein kinase C in astrocyte and microglia cultures.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Astrocytes; Cell Membrane; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cytosol; Enzyme Inhibitors; Homeostasis; Isoproterenol; Kinetics; Microglia; Naphthalenes; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Induction of neutrophil chemotactic factor production by staurosporine in rat peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Dose-Response Relationship, Drug; Growth Substances; Intercellular Signaling Peptides and Proteins; Male; Neutrophils; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs.
Topics: Alkaloids; Animals; Benzophenanthridines; Carcinogens; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Hormone; Growth Hormone-Releasing Hormone; Isoquinolines; Naphthalenes; Oligopeptides; Phenanthridines; Pituitary Gland; Protein Kinase C; Second Messenger Systems; Sheep; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils.
Topics: Adult; Humans; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxazoles; Phosphatidic Acids; Phospholipase D; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Inflammatory potency of activin A. Effect on prostanoid and nitric oxide formation.
Topics: Activins; Animals; Bone Marrow Cells; Cell Differentiation; Cinnamates; Cyclooxygenase 2; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Genistein; Inflammation; Inhibins; Interleukin-2; Isoenzymes; Lipopolysaccharides; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Necrosis Factor-alpha; Tyrphostins | 1997 |
Effects of inhibitors of signal transduction pathways on transforming growth factor beta1 and osteogenic protein-1-induced insulinlike growth factor binding protein-3 expression in human bone cells.
Topics: Bone and Bones; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cells, Cultured; Culture Media, Conditioned; Gene Expression Regulation; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 3; Isoflavones; Okadaic Acid; Osteoblasts; Phosphoprotein Phosphatases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Vanadates | 1997 |
Activation of endothelin ETA receptors induces phosphorylation of alpha1b-adrenoreceptors in Rat-1 fibroblasts.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Fibroblasts; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Norepinephrine; Peptides, Cyclic; Phosphorylation; Rats; Receptor, Endothelin A; Receptors, Adrenergic, alpha-1; Receptors, Endothelin; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1997 |
SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Enzyme Inhibitors; Epidermis; Humans; Hyperplasia; Keratinocytes; Male; Mice; Mice, Hairless; Molecular Structure; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Cofilin undergoes rapid dephosphorylation in stimulated neutrophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation.
Topics: Actin Depolymerizing Factors; Actins; Amino Acid Sequence; Animals; Calcimycin; Cell Membrane; Diglycerides; Diterpenes; Guinea Pigs; Humans; Hydrogen Peroxide; Immunoblotting; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Oxides; Phosphorylation; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1997 |
Effect of interferon gamma on T lymphocytes from patients with multiple sclerosis.
Topics: Antineoplastic Agents; Calcium; Carcinogens; Cells, Cultured; Chlorides; Enzyme Inhibitors; Female; Homeostasis; Humans; Imidazoles; Interferon-gamma; Lymphocyte Activation; Male; Multiple Sclerosis; Sodium; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1995 |
Characteristics of protein-kinase-C- and ADP-ribosylation-factor-stimulated phospholipase D activities in human embryonic kidney cells.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Cell Line; Digitonin; GTP-Binding Proteins; GTPase-Activating Proteins; Guanine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoenzymes; Kidney; Neomycin; Permeability; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Involvement of different transduction pathways in NF-kappa B activation by several inducers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Antioxidants; Base Sequence; Binding Sites; Cell Line; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Kinetics; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Protein Kinase Inhibitors; Reactive Oxygen Species; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Regulation of cellular phosphorylation of hyaluronan binding protein and its role in the formation of second messenger.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Hyaluronan Receptors; Hyaluronic Acid; Immunoblotting; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Marine Toxins; Oxazoles; Phospholipase C gamma; Phosphorylation; Polyomavirus; Protein Kinase Inhibitors; Protein Kinases; Rats; Second Messenger Systems; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Inhibitory effect of 2-phenyl-4-quinolone on serotonin-mediated changes in the morphology and permeability of endothelial monolayers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cattle; Cell Size; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium; Enzyme Inhibitors; Gap Junctions; Myocardium; Nitroprusside; Permeability; Protein Kinase C; Quinolones; Rats; Serotonin; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Relocation of annexin V to platelet membranes is a phosphorylation-dependent process.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Annexin A5; Biological Transport; Blood Platelets; Calcimycin; Cell Compartmentation; Humans; Membranes; Okadaic Acid; Phosphoproteins; Phosphorylation; Platelet Activation; Protein Binding; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells.
Topics: Astrocytoma; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-fos; Staurosporine; Substance P; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1997 |
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells.
Topics: Aldosterone; Animals; Anti-Bacterial Agents; Cell Line; Dogs; Enzyme Inhibitors; Hydrogen-Ion Concentration; Imidazoles; Kidney; Kinetics; Macrolides; Meglumine; Membrane Potentials; Naphthalenes; Pertussis Toxin; Protein Kinase C; Protein Serine-Threonine Kinases; Proton Pump Inhibitors; Proton-Translocating ATPases; Sodium-Hydrogen Exchangers; Spironolactone; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Zinc | 1997 |
Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium.
Topics: Actin Cytoskeleton; Actins; Animals; Aorta; Cattle; Cell Size; Cells, Cultured; Colforsin; Cytochalasin D; Cytoskeleton; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Genistein; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Inhibition of PAH transport by parathyroid hormone in OK cells: involvement of protein kinase C pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Bucladesine; Cell Line; Cell Membrane; Colforsin; Kidney; Kinetics; Mannitol; p-Aminohippuric Acid; Protein Kinase C; Second Messenger Systems; Staurosporine; Teriparatide; Tetradecanoylphorbol Acetate | 1997 |
Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation.
Topics: Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Flavonoids; Gene Expression Regulation; Humans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Polymerase Chain Reaction; Protein Kinase C; Receptors, LDL; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Regulation of the alpha 2 beta 1 and alpha 3 beta 1 isozymes of the Na,K-ATPase by Ca2+, PKA, and PKC.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Calcium; Cell Line; Cyclic AMP-Dependent Protein Kinases; Macromolecular Substances; Protein Kinase C; Rats; Recombinant Proteins; Sodium-Potassium-Exchanging ATPase; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Reduced cholecystokinin receptor phosphorylation and restored signalling in protein kinase C down-regulated rat pancreatic acinar cells.
Topics: Animals; Calcium; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Immunoblotting; Isoenzymes; Kinetics; Pancreas; Phosphorylation; Protein Kinase C; Rats; Receptors, Cholecystokinin; Signal Transduction; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Suppression of GnRH gene expression in GT1-1 hypothalamic neuronal cells: action of protein kinase C.
Topics: Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Gonadotropin-Releasing Hormone; Hypothalamus; Isoenzymes; Luciferases; Mice; Naphthalenes; Neurons; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-fos; Recombinant Fusion Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1997 |
Activation of the human histamine H2 receptor is linked to cell proliferation and c-fos gene transcription.
Topics: Cell Division; Cell Line; Cimetidine; Cloning, Molecular; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Epinephrine; Genes, fos; Genes, Reporter; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Luciferases; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptors, Histamine H2; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1997 |
Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid.
Topics: Adrenal Glands; Animals; Calcium; Carbachol; Catecholamines; Cattle; Chromaffin Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Genistein; Lysophospholipids; Naphthalenes; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sodium; Sodium-Calcium Exchanger; Staurosporine; Structure-Activity Relationship; Suramin; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Topics: Antigens, Neoplasm; Apoptosis; Brefeldin A; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cycloheximide; Cyclopentanes; Dactinomycin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Immunologic Capping; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Protein kinase C regulation of organic anion transport in renal proximal tubule.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Enzyme Inhibitors; Epithelial Cells; Fluorescein; Homeostasis; Kidney Tubules, Proximal; Killifishes; Models, Biological; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells.
Topics: Animals; bcl-2-Associated X Protein; Bucladesine; Cell Death; Dimerization; DNA Fragmentation; Gene Expression; Genes, p53; Humans; Immunohistochemistry; Mice; Neuroblastoma; Nitric Oxide; Oxidation-Reduction; Penicillamine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; S-Nitroso-N-Acetylpenicillamine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.
Topics: Animals; Bryostatins; Cell Division; Drug Synergism; Enzyme Activation; Growth Inhibitors; Lactones; Leukemia P388; Macrolides; Mice; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1998 |
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antimetabolites; Carcinogens; Cells, Cultured; Cyclic AMP; Deoxyglucose; Diuretics, Osmotic; Enzyme Inhibitors; Estrenes; Gene Expression; Glucose; Growth Hormone; Kidney; Mannitol; Opossums; Phosphodiesterase Inhibitors; Phospholipases A; Pyrrolidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1998 |
Protein kinase C is required for long-lasting synaptic enhancement by the neuropeptide DRNFLRFamide in crayfish.
Topics: Alkaloids; Animals; Astacoidea; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; FMRFamide; Indoles; Maleimides; Neuronal Plasticity; Phenanthridines; Protein Kinase C; Staurosporine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C plays an important role in the human zona pellucida-induced acrosome reaction.
Topics: Acrosome; Culture Media; Cyclic AMP; Cyclic GMP; Female; Humans; Male; Pentoxifylline; Protein Kinase C; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida | 1997 |
Characterization and properties of protein kinase C from the filamentous fungus Trichoderma reesei.
Topics: Chromatography, Affinity; Chromatography, Ion Exchange; Enzyme Inhibitors; Fungal Proteins; Indoles; Kinetics; Maleimides; Molecular Weight; Phosphorylation; Protein Kinase C; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate; Trichoderma | 1998 |
Change of ganglioside accessibility at the plasma membrane surface of cultured neurons, following protein kinase C activation.
Topics: Animals; Cell Membrane; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Gangliosides; Glutamic Acid; Neuraminidase; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vibrio cholerae | 1998 |
Adrenomedullin gene expression and its different regulation in human adrenocortical and medullary tumors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenoma; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Glands; Adrenomedullin; Blotting, Northern; Carcinoma; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Humans; Peptides; Pheochromocytoma; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors.
Topics: Animals; Anti-Anxiety Agents; Chloride Channels; Desoxycorticosterone; Enzyme Activation; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Oocytes; Phorbol Esters; Pregnenolone; Protein Kinase C; Receptors, GABA-A; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis | 1997 |
The microbial alkaloid toxin staurosporine blocks the phorbol ester-induced increase in beta-amyloid precursor protein in PC12 cells.
Topics: Alkaloids; Amyloid beta-Protein Precursor; Animals; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Indoles; Isomerism; Maleimides; PC12 Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Protein kinase C induced changes in erythrocyte Na+/H+ exchange and cytosolic free calcium in humans.
Topics: Calcium; Calpain; Carcinogens; Cytosol; Enzyme Inhibitors; Erythrocytes; Humans; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Alkaloids; Animals; Benzophenanthridines; CD3 Complex; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cycloheximide; Dactinomycin; Enzyme Activation; Enzyme Inhibitors; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phenanthridines; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Up-Regulation | 1998 |
Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells.
Topics: Astrocytoma; Brain Neoplasms; Cytokines; Dipeptides; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Indoles; Interleukin-6; Interleukin-8; Leukemia Inhibitory Factor; Lymphokines; Neoplasm Proteins; Neurokinin-1 Receptor Antagonists; Protein Kinase C; Receptors, Neurokinin-1; RNA, Messenger; RNA, Neoplasm; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Effects of protein kinase C activators and staurosporine on protein kinase activity, cell survival, and proliferation in Tetrahymena thermophila.
Topics: Animals; Autoradiography; Croton Oil; Diglycerides; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Myelin Basic Protein; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tetrahymena thermophila | 1997 |
Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor.
Topics: Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Calcium Channels; Cannabinoids; Carcinogens; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Hormone Antagonists; Indoles; Maleimides; Morpholines; Mutagenesis; Naphthalenes; omega-Conotoxin GVIA; Peptides; Phorbols; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Protein Structure, Tertiary; Rats; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Serine; Signal Transduction; Somatostatin; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Detection of antitumor promoting activity in Raji cells carrying Epstein-Barr virus genome by immunoblotting analysis.
Topics: Animals; Antibodies, Viral; Antigens, Viral; Blotting, Western; Butyrates; Butyric Acid; Carcinogens; Cell Line, Transformed; Curcumin; Electrophoresis, Polyacrylamide Gel; Genome, Viral; Herpesvirus 4, Human; Histamine Antagonists; Humans; Immunoblotting; Mice; Microscopy, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Luteinizing hormone-releasing hormone-signal transduction and stathmin phosphorylation in the gonadotrope alphaT3-1 cell line.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Mice; Mice, Transgenic; Microtubule Proteins; Phosphoproteins; Phosphorylation; Pituitary Gland; Protein Kinase C; Signal Transduction; Stathmin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Selective activation by bryostatin-1 demonstrates unique roles for PKC epsilon in neurite extension and tau phosphorylation.
Topics: Bryostatins; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Lactones; Macrolides; Neurites; Neurons; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Staurosporine; tau Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Differential effects on TNF alpha production by pharmacological agents with varying molecular sites of action.
Topics: Benzoquinones; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-10; Interleukin-4; Lactams, Macrocyclic; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Quinones; Rifabutin; Signal Transduction; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Activity-dependent regulation of [Ca2+]i in avian cochlear nucleus neurons: roles of protein kinases A and C and relation to cell death.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apoptosis; Autonomic Denervation; Brain Stem; Calcium; Chick Embryo; Cochlear Nucleus; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Estrenes; Homeostasis; Indoles; Ion Transport; Maleimides; Nerve Tissue Proteins; Protein Kinase C; Pyrrolidinones; Receptors, Metabotropic Glutamate; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides | 1998 |
Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells.
Topics: Apoptosis; Avian Proteins; Base Sequence; CDX2 Transcription Factor; Cell Division; Cell Movement; Ceramides; Colonic Neoplasms; Culture Media, Serum-Free; DNA Primers; Down-Regulation; Genes, bcl-2; Genes, Homeobox; Homeodomain Proteins; HT29 Cells; Humans; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection | 1998 |
Novel protein kinase C, nPKC, inhibition of murine bumetanide-sensitive Na+,K+,2Cl- cotransporter BSC1 in Xenopus oocyte.
Topics: Animals; Bumetanide; Carrier Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Gene Transfer Techniques; Mice; Naphthalenes; Oocytes; Protein Kinase C; Recombinant Proteins; Rubidium; Sodium-Potassium-Chloride Symporters; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus | 1998 |
Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.
Topics: Animals; Carbachol; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Isoenzymes; Pancreatic Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cattle; Cell Communication; Cells, Cultured; Connexin 43; Dose-Response Relationship, Drug; Enzyme Activation; Gap Junctions; Glucose; Mannitol; Muscle, Smooth, Vascular; Naphthalenes; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
[Interleukin-2 and staurosporine abolish inhibition of splenocyte nonspecific cytotoxicity caused by high doses of phorbol myristate acetate in rats].
Topics: Animals; Cell Division; Cell Survival; Cytotoxicity, Immunologic; Drug Synergism; Enzyme Inhibitors; Humans; Interleukin-2; Male; Rats; Rats, Wistar; Spleen; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
1alpha,25(OH)2-vitamin D3 signaling in chick enterocytes: enhancement of tyrosine phosphorylation and rapid stimulation of mitogen-activated protein (MAP) kinase.
Topics: Animals; Calcitriol; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chickens; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genistein; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
IL-4 secretion and histamine release by human basophils are differentially regulated by protein kinase C activation.
Topics: Basophils; Calcium; Cells, Cultured; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Histamine Release; Humans; Interleukin-4; Ionomycin; Ionophores; Lymphocytes; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
TNF alpha induces a protein kinase C-dependent reduction in astroglial K+ conductance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Barium; Brain; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Membrane Potentials; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Effects of kappa-opioid receptor stimulation in the heart and the involvement of protein kinase C.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Heart; In Vitro Techniques; Inosine Triphosphate; Male; Myocardium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sarcoplasmic Reticulum; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1998 |
Endothelin-stimulated capacitative calcium entry in enteric glial cells: synergistic effects of protein kinase C activity and nitric oxide.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcium; Calcium Channels; Carcinogens; Cells, Cultured; Drug Synergism; Endothelin-3; Enzyme Inhibitors; Guinea Pigs; Myenteric Plexus; Neuroglia; Nickel; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Penicillamine; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Staurosporine-induced versus spontaneous squamous metaplasia in pre- and postmenopausal breast tissue.
Topics: Adult; Aged; Anticarcinogenic Agents; Breast; Breast Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Keratin-10; Keratinocytes; Keratins; Middle Aged; Naphthalenes; Postmenopause; Premenopause; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Thrombomodulin; Tumor Cells, Cultured; Up-Regulation | 1998 |
Multiple second-messenger system modulation of voltage-activated calcium currents in teleost retinal horizontal cells.
Topics: Animals; Bass; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Dopamine; Enzyme Activation; GTP-Binding Proteins; Membrane Potentials; Models, Biological; Neurons; Protein Kinase C; Retina; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Theophylline | 1998 |
Human B lymphocytes synthesize the 92-kDa gelatinase, matrix metalloproteinase-9.
Topics: Androstadienes; B-Lymphocytes; Captopril; Cell Movement; Collagenases; Concanavalin A; Cytokines; Gene Expression Regulation, Enzymologic; Growth Substances; Herpesvirus 4, Human; Humans; Lipopolysaccharides; Matrix Metalloproteinase 9; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Transformation, Genetic; Transforming Growth Factor beta; Wortmannin | 1998 |
Extracellular ATP and bradykinin increase cGMP in vascular endothelial cells via activation of PKC.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Bradykinin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fetus; Kinetics; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phorbol Esters; Polyethylene Glycols; Protein Kinase C; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Time Factors; Vasodilator Agents | 1998 |
Release of a leukocyte activation inhibitor by staurosporine-treated pulmonary artery endothelial cells.
Topics: Animals; Biological Factors; Calcimycin; Cattle; Cell Adhesion; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Diethylcarbamazine; Endothelium, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptidyl-Dipeptidase A; Protein Kinase C; Pulmonary Artery; Rabbits; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
Topics: Calcium; Cell Line; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Mutagenesis, Site-Directed; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Receptors, Calcium-Sensing; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate; Threonine; Type C Phospholipases | 1998 |
Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter.
Topics: Animals; Carrier Proteins; Cell Line; Cloning, Molecular; Cocaine; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phorbol Esters; Protein Kinase C; Recombinant Proteins; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection | 1998 |
Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability.
Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Protein Kinase C; Rats; Serotonin; Serotonin Antagonists; Staurosporine; Tetradecanoylphorbol Acetate; Xanthenes | 1998 |
PMA and staurosporine affect expression of the PCK gene in LLC-PK1-F+ cells.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Half-Life; Hydrogen-Ion Concentration; Kidney; Kinetics; LLC-PK1 Cells; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions, Genetic; RNA, Messenger; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1998 |
Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.
Topics: 3T3 Cells; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprost; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Iodides; Isoquinolines; Kinetics; Mice; Phosphopeptides; Phosphorylation; Protein Kinase C; Recombinant Proteins; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Activation of H+-ATPase by hypotonicity: a novel regulatory mechanism for H+ secretion in IMCD cells.
Topics: Ammonium Chloride; Animals; Cell Line; Cells, Cultured; Enzyme Activation; Fluoresceins; Hydrogen-Ion Concentration; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Naphthalenes; Osmolar Concentration; Protein Kinase C; Proton-Translocating ATPases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium | 1998 |
Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Drug Synergism; Female; Gene Expression Regulation; Interferon-gamma; Interleukin-4; Ionomycin; Mercuric Chloride; Protein Kinase Inhibitors; Rats; Rats, Inbred BN; Receptors, Immunologic; Receptors, OX40; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Th2 Cells; Tumor Necrosis Factor Receptor Superfamily, Member 7; Tumor Necrosis Factor-alpha | 1998 |
Reduced level of ATF is correlated with transcriptional repression of DNA topoisomerase II alpha gene during TPA-induced differentiation of HL-60 cells.
Topics: Activating Transcription Factors; Antigens, Neoplasm; Binding Sites; Blood Proteins; Blotting, Northern; Cell Differentiation; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Repression; HL-60 Cells; Humans; Isoenzymes; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1998 |
Assessment of the mechanism by which prolactin stimulates progesterone production by early corpora lutea of pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Cells, Cultured; Corpus Luteum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Ionomycin; Ionophores; Lipoproteins, LDL; Luteal Phase; Phorbol 12,13-Dibutyrate; Progesterone; Prolactin; Protein Kinase C; Staurosporine; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1998 |
The role of protein kinase C in the desensitization of rat pancreatic islets to cholinergic stimulation.
Topics: Analysis of Variance; Animals; Carbachol; Enzyme Inhibitors; Female; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muscarinic Agonists; Peptide Fragments; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1998 |
Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid.
Topics: Alkaloids; Benzophenanthridines; Biological Transport; Biotin; Cell Line; Colon; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Humans; Intestinal Absorption; Intestinal Mucosa; Kinetics; Pantothenic Acid; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter.
Topics: Aged; Animals; Antineoplastic Agents; Astrocytes; Bromodeoxyuridine; Cell Cycle; Enzyme Inhibitors; Female; Glioblastoma; Humans; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Middle Aged; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Tissue factor activity of SW-480 human colon adenocarcinoma cells is modulated by thrombin and protein kinase C activation.
Topics: Adenocarcinoma; Coagulants; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Hemostatics; Humans; Neoplasm Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Thromboplastin; Tumor Cells, Cultured | 1998 |
Analysis of heat shock-induced monophosphorylation of stathmin in human T lymphoblastic cell line JURKAT by two-dimensional gel electrophoresis.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclosporine; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Hot Temperature; Humans; Isoelectric Point; Jurkat Cells; Microtubule Proteins; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Stathmin; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Effects of genistein and staurosporine on angiotensin II-induced DNA synthesis, protein synthesis and mitogen-activated protein kinase activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Male; Muscle Proteins; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1998 |
Involvement of protein kinases and phosphatases in tyrosine phosphorylation of PKCdelta in rat parotid acinar cells exposed to secretory stimuli.
Topics: Animals; Carbachol; Carcinogens; Enzyme Inhibitors; Epithelial Cells; Genistein; Isoenzymes; Muscarinic Agonists; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney.
Topics: Animals; Anion Transport Proteins; Anions; Biological Transport; Carrier Proteins; Cell Membrane; Dicarboxylic Acids; Diterpenes; DNA Primers; DNA, Complementary; Female; Folic Acid; Glutarates; Kidney; Kinetics; Methotrexate; Oocytes; p-Aminohippuric Acid; Phorbol Esters; Probenecid; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Xenopus laevis | 1998 |
The role of protein kinase C alpha and epsilon isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line.
Topics: Astrocytoma; Atropine; Carbachol; Carcinogens; DNA; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Radioligand Assay; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1998 |
Protein kinase C-independent selective induction of nitric oxide synthase activity in rat alveolar macrophages by staurosporine.
Topics: Animals; Carbazoles; Cell Line; Enzyme Induction; Enzyme Inhibitors; Indole Alkaloids; Isoenzymes; Lipopolysaccharides; Macrophages, Alveolar; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzophenanthridines; Benzoquinones; Brain; Carcinogens; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lactams, Macrocyclic; Microglia; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Calphostin C induces expression of amphiregulin mRNA via reactive oxygen species in IEC-6 cells.
Topics: Acetylcysteine; Amphiregulin; Animals; Cell Line; Drug Interactions; EGF Family of Proteins; Enzyme Inhibitors; Epithelial Cells; Free Radical Scavengers; Glycoproteins; Growth Substances; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Intestines; Naphthalenes; Rats; Reactive Oxygen Species; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1--dissection of the androgen receptor functional domains.
Topics: Aldehyde Reductase; Androgens; Animals; Breast Neoplasms, Male; COS Cells; DNA; Enzyme Inhibitors; Genes, Reporter; Genetic Engineering; Humans; Luciferases; Male; Marine Toxins; Mice; Mutation; Okadaic Acid; Oxazoles; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Androgen; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 1999 |
Role of Ca2+-ATPase inhibitors in activation of cytosolic phospholipase A2 in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cell-Free System; Chelating Agents; Cytosol; DNA, Complementary; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Lipid Metabolism; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Binding; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; U937 Cells | 1999 |
Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: implications for cell death.
Topics: Animals; Apoptosis; Cells, Cultured; Cricetinae; Cricetulus; Culture Media, Serum-Free; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Fibroblasts; Isoenzymes; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Modulation of arterial Na+-K+-ATPase-induced [Ca2+]i reduction and relaxation by norepinephrine, ET-1, and PMA.
Topics: Animals; Calcium; Cytoplasm; Endothelin-1; Male; Mesenteric Arteries; Norepinephrine; Osmolar Concentration; Potassium Chloride; Sodium-Potassium-Exchanging ATPase; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1999 |
Functional regulation of Galpha16 by protein kinase C.
Topics: Amino Acid Sequence; Animals; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Oocytes; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus | 1999 |
Study on the activation of phospholipases A2 by purinergic agonists in rat submandibular ductal cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cations, Divalent; Cell Membrane Permeability; Enzyme Activation; In Vitro Techniques; Male; Oleic Acid; Phospholipases A; Phospholipases A2; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Staurosporine; Submandibular Gland; Tetradecanoylphorbol Acetate | 1999 |
Regulation of the high-affinity H+/peptide cotransporter in renal LLC-PK1 cells.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Survival; Dipeptides; Enzyme Inhibitors; Hydrogen-Ion Concentration; Imidazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Protein Kinase C; Signal Transduction; Staurosporine; Stereoisomerism; Sulfonamides; Swine; Symporters; Tetradecanoylphorbol Acetate; Trifluoperazine | 1999 |
Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat-1 fibroblasts stably expressing alpha1d-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cell Line; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Endothelin-1; Fibroblasts; Norepinephrine; Phentolamine; Piperazines; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells.
Topics: Blotting, Northern; Blotting, Western; Burkitt Lymphoma; CCCTC-Binding Factor; Cell Differentiation; Cytarabine; Dimethyl Sulfoxide; DNA-Binding Proteins; Down-Regulation; Erythrocytes; Gene Expression Regulation; Humans; Isoelectric Focusing; Leukemia, Myeloid; Leukocytes; Megakaryocytes; Phosphorylation; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA Processing, Post-Transcriptional; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1999 |
Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor.
Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Activation of mitogen activated protein kinase in human platelets by genistein.
Topics: Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Mitogen-Activated Protein Kinase 1; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1999 |
Protein kinase C mediates experimental colitis in the rat.
Topics: Animals; Colitis; Colon; Enzyme Inhibitors; Ethanol; Indoles; Intestinal Mucosa; Isoenzymes; Male; Maleimides; Neutropenia; Peroxidase; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Trinitrobenzenesulfonic Acid | 1999 |
A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells.
Topics: Amiloride; Angiotensin II; Animals; Antihypertensive Agents; Cells, Cultured; Cyclic AMP; Diuretics; Imidazoles; Kidney Tubules, Proximal; Losartan; Male; Protein Kinase C; Pyridines; Rabbits; Receptors, Angiotensin; Signal Transduction; Sodium; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Regulation of Ca2+ influx by a protein kinase C activator in chromaffin cells: differential role of P/Q- and L-type Ca2+ channels.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carcinogens; Cattle; Chromaffin Cells; Dose-Response Relationship, Drug; Enzyme Activation; Fluorescence; Fura-2; Manganese; Nitrendipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Potassium; Protein Kinase C; Spider Venoms; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
A role for phosphorylation in the dynamics of keratin intermediate filaments.
Topics: Adenine; Blotting, Western; Cell Line; Cytoskeleton; Densitometry; Fluorescent Antibody Technique; Intermediate Filaments; Keratins; Okadaic Acid; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1999 |
Interferon-gamma, bacterial lipopolysaccharide, and tumor necrosis factor-alpha induce CD11a mRNA and protein via Na+/H+ exchange and protein kinase C-dependent mechanisms in tissue macrophages.
Topics: Amiloride; Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Interferon-gamma; Lipopolysaccharides; Lymphocyte Function-Associated Antigen-1; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Protein Kinase C; Receptors, IgG; RNA, Messenger; Second Messenger Systems; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Thioglycolates; Time Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha | 1999 |
Expression and characterization of protein kinase C in isolated rabbit parietal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminopyrine; Animals; Calcium; Cimetidine; Enzyme Inhibitors; Histamine; In Vitro Techniques; Isoenzymes; Male; Parietal Cells, Gastric; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protons; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Ca2+ and protein kinase C signaling for histamine and sulfidoleukotrienes released from human cultured mast cells.
Topics: Animals; Antibodies; Calcimycin; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Activation; Histamine; Humans; Immunoglobulin E; Leukotrienes; Mast Cells; Protein Kinase C; Rodentia; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent.
Topics: Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Indoles; Lipopolysaccharides; Maleimides; Monocytes; NF-kappa B; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Redox modulation of intracellular free calcium concentration in thyroid FRTL-5 cells: evidence for an enhanced extrusion of calcium.
Topics: Animals; Barium; Calcium; Calcium-Transporting ATPases; Cell Line; Enzyme Activation; Hydrogen-Ion Concentration; Imidazoles; Membrane Potentials; Mercaptoethanol; Oxidation-Reduction; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Binding; Protein Kinase C; Rats; Staurosporine; tert-Butylhydroperoxide; Tetradecanoylphorbol Acetate; Thapsigargin; Thimerosal; Thyroid Gland; Vanadates | 1999 |
Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca2+ and protein kinase C activity.
Topics: Animals; Butanols; Calcium; Cell Membrane; Cell-Free System; Cytosol; Egtazic Acid; Flavonoids; In Vitro Techniques; Isoenzymes; Kinetics; NADPH Oxidases; Neutrophils; Pertussis Toxin; Protein Kinase C; Rats; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1999 |
Sustained phospholipase D activation is associated with keratinocyte differentiation.
Topics: Animals; Bradykinin; Cell Differentiation; Enzyme Activation; Keratinocytes; Mice; Phosphatidic Acids; Phosphatidylethanolamines; Phospholipase D; Protein Isoforms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transglutaminases | 1999 |
Cytoskeletal changes in platelets induced by thrombin and phorbol myristate acetate (PMA).
Topics: Actins; Animals; Aspirin; Blood Platelets; Cytoskeletal Proteins; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Kinetics; Microfilament Proteins; Molecular Weight; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Thrombin | 1998 |
Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells.
Topics: Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glioblastoma; Humans; Isoenzymes; Lymphokines; Oligonucleotides, Antisense; Protein Kinase C; RNA Processing, Post-Transcriptional; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Effect of water extracts of Rhizopus delemar on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors.
Topics: Enzyme Inhibitors; Genistein; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Protein Kinase Inhibitors; Rhizopus; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Water | 1999 |
Protein kinases A and C are opponents in modulating glial Ca2+ -activated K+ channels.
Topics: Animals; Bucladesine; Calcimycin; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; Neuroglia; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C; Rabbits; Retina; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Phorbol ester modulation of active ion transport across the rabbit conjunctival epithelium.
Topics: Animals; Biological Transport, Active; Bumetanide; Chlorine; Conjunctiva; Culture Techniques; Enzyme Inhibitors; Female; Ion Transport; Male; Ouabain; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Protein kinase C-dependent activation of NF-kappaB in enterocytes is independent of IkappaB degradation.
Topics: Biological Transport; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Humans; I-kappa B Proteins; Interleukin-1; Intestinal Mucosa; Intestines; Kinetics; NF-kappa B; Protein Kinase C; Proto-Oncogene Proteins c-fos; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes.
Topics: Autoantibodies; Autoantigens; Cadherins; Cell Line; Cytoskeletal Proteins; Desmoglein 3; Desmogleins; Desmoplakins; Desmosomes; gamma Catenin; Humans; Immunoglobulin G; Keratinocytes; Pemphigus; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Regulation of 5-hydroxytryptamine-induced signal transduction in canine cultured aorta smooth muscle cells by phorbol ester.
Topics: Animals; Aorta; Calcium; Cell Membrane; Cells, Cultured; Cytosol; Dogs; Enzyme Inhibitors; Inositol Phosphates; Isoenzymes; Muscle, Smooth, Vascular; Protein Kinase C; Serotonin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
PKC-beta and PKC-zeta mediate opposing effects on proximal tubule Na+,K+-ATPase activity.
Topics: Animals; Dopamine; Enzyme Inhibitors; Indoles; Isoenzymes; Kidney Tubules, Proximal; Maleimides; Opossums; Peptides; Protein Kinase C; Protein Kinase C beta; Rubidium; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Muscle, Smooth, Vascular; Naphthalenes; Necrosis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reactive Oxygen Species; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Interferon-gamma induces apoptosis and expression of inflammation-related proteins in Chang conjunctival cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Cycle; Cell Division; Cell Line; Cell Survival; Conjunctiva; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epithelial Cells; Fas Ligand Protein; Flow Cytometry; HLA-DR Antigens; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Membrane Glycoproteins; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; STAT1 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Tumor Suppressor Protein p53 | 1999 |
Determination of queuosine modification system deficiencies in cultured human cells.
Topics: Azacitidine; Cells, Cultured; Enzyme Inhibitors; Guanine; Humans; Male; Nucleoside Q; Phosphorylation; Protein Kinase C; RNA, Transfer; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1999 |
The involvement of protein kinase C in the regulation of choline cotransport in Limulus.
Topics: Animals; Arachidonic Acids; Biological Transport; Brain; Carcinogens; Carrier Proteins; Choline; Cholinergic Agents; Enzyme Inhibitors; Hemicholinium 3; Horseshoe Crabs; Nervous System; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Potassium Chloride; Protein Kinase C; Quinacrine; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Dual effect of spermine on mast cell secretion exhibits different calcium and temperature requirements.
Topics: Animals; Calcium; Cholera Toxin; Depression, Chemical; In Vitro Techniques; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Serotonin; Spermine; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1999 |
Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Carcinogens; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; K562 Cells; Macrophages; Monocytes; Phenotype; Protein Kinase C; Proto-Oncogene Proteins c-myc; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors | 1999 |
[3H] gamma-aminobutyric acid transport in rat substantia nigra pars reticulata synaptosomes: pharmacological characterization and phorbol ester-induced inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Basal Ganglia; beta-Alanine; Biological Transport; Carcinogens; Colforsin; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substantia Nigra; Synaptosomes; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alprostadil; Animals; Calcium; Cell Line; Cholera Toxin; Colchicine; Colforsin; Cyclic AMP; Cytochalasin B; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; GTP-Binding Proteins; Indoles; Isoenzymes; Isoproterenol; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1999 |
The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells.
Topics: Animals; Azoles; Cell Survival; Colon; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Activation; Imidazoles; Indoles; Intestinal Mucosa; Isoenzymes; Isoindoles; Male; Maleimides; Nitric Oxide; Nitric Oxide Donors; Organoselenium Compounds; Penicillamine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Nitric oxide activates PKCalpha and inhibits Na+-K+-ATPase in opossum kidney cells.
Topics: Alkaloids; Animals; Arachidonic Acids; Carbazoles; Cell Line; Enzyme Activation; Enzyme Inhibitors; Estrenes; Indoles; Isoenzymes; Kidney; Kidney Tubules, Proximal; Kinetics; Naphthalenes; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Opossums; Protein Kinase C; Protein Kinase C-alpha; Pyrrolidinones; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+.
Topics: 17-alpha-Hydroxyprogesterone; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Drug Synergism; Fura-2; Gonadotropin-Releasing Hormone; Ionomycin; Leydig Cells; Luteinizing Hormone; Male; Melatonin; Pertussis Toxin; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Intracellular Ca2+ and delay of ischemia-induced electrical uncoupling in preconditioned rabbit ventricular myocardium.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Enzyme Activation; Enzyme Inhibitors; Female; Glyburide; In Vitro Techniques; Indoles; Intracellular Fluid; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Myocardium; Papillary Muscles; Potassium Channels; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Interaction of respiratory burst and uptake of dehydroascorbic acid in differentiated HL-60 cells.
Topics: Biological Transport; Biphenyl Compounds; Cell Differentiation; Dehydroascorbic Acid; Glucose; Glutathione; HL-60 Cells; Humans; Neutrophils; Onium Compounds; Oxidation-Reduction; Protein Kinase C; Reducing Agents; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 2000 |
Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow.
Topics: Adult; Antigens, CD; Antigens, CD34; Bone Marrow Cells; Cell Differentiation; Cell Nucleus; Cells, Cultured; Enzyme Inhibitors; Erythropoietin; Gene Expression Regulation, Enzymologic; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Isoenzymes; Naphthalenes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Recombinant Proteins; Staurosporine; Stem Cell Factor; Tetradecanoylphorbol Acetate | 2000 |
Mechanisms of cGMP-dependent mesangial-cell relaxation: a role for myosin light-chain phosphatase activation.
Topics: Angiotensin II; Animals; Azepines; Calcium; Calcium Signaling; Cell Size; Cells, Cultured; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Glomerular Mesangium; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Inhibition of bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilisation by phorbol ester in rat cultured vascular smooth muscle cells.
Topics: Animals; Biological Transport; Bradykinin; Calcium Signaling; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Maleimides; Muscle, Smooth, Vascular; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Reductase; Animals; Benzothiazoles; Cell Line; Drug Synergism; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phthalazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles | 1999 |
Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.
Topics: Animals; Calcium; Carbachol; Cholinergic Agonists; Enzyme Activation; Enzyme Inhibitors; Fura-2; Isoenzymes; Lacrimal Apparatus; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid.
Topics: Animals; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Pyrans; Pyrethrins; Rats; Receptors, Adrenergic, alpha-1; Spiro Compounds; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Induction and secretion of the chemokines interleukin-8 and monocyte chemotactic protein-1 in human immature leukemia cell lines.
Topics: Calcimycin; Carcinogens; Chemokine CCL2; Chemokines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; HL-60 Cells; Humans; Interleukin-8; Ionophores; Leukemia; Protein Biosynthesis; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Topics: Animals; Aorta; Body Water; Bradykinin; Capillary Permeability; Cattle; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Infant, Newborn; Lymphokines; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Penicillamine; Protein Kinase C; Retina; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
The effect of protein kinase C activation on colonic epithelial cellular integrity.
Topics: Animals; Colon; Dose-Response Relationship, Drug; Enzyme Activation; Hydrogen Peroxide; Intestinal Mucosa; Isoenzymes; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Calcium; Cells, Cultured; Collagen; Felodipine; Fluorescent Dyes; Fura-2; Glutathione; Homocysteine; Homocystine; Kinetics; Muscle, Smooth, Vascular; Neomycin; NG-Nitroarginine Methyl Ester; Pravastatin; Rats; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils.
Topics: Acetophenones; Antigens, CD; Benzopyrans; Cells, Cultured; Chemotactic Factors; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dipeptides; Down-Regulation; Humans; Hydroxamic Acids; L-Selectin; Metalloendopeptidases; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Protein kinase C phosphorylates and regulates UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase.
Topics: Amino Acid Motifs; Animals; Carbohydrate Epimerases; Cell Line; Consensus Sequence; Enzyme Activation; Escherichia coli Proteins; Isoenzymes; Liver; Mice; Multienzyme Complexes; Neuraminic Acids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Protein Binding; Protein Kinase C; Recombinant Proteins; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C.
Topics: Alkaloids; Animals; Benzophenanthridines; Cell Division; Cells, Cultured; DNA; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Interleukin-1; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Myocardium; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Kinase regulation of hENaC mediated through a region in the COOH-terminal portion of the alpha-subunit.
Topics: Animals; Enzyme Inhibitors; Epithelial Sodium Channels; Female; Humans; In Vitro Techniques; Mutagenesis, Site-Directed; Oocytes; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Structure, Quaternary; Recombinant Proteins; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis | 2000 |
Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway.
Topics: Amino Acid Sequence; Animals; Carbazoles; Cell Cycle Proteins; Cell Line; Gene Expression Regulation; Golgi Apparatus; Humans; Indole Alkaloids; Interferons; Membrane Transport Proteins; Mice; Molecular Sequence Data; NF-kappa B; Phosphoproteins; Phosphorylation; Sequence Homology, Amino Acid; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factor TFIIIA; Tumor Necrosis Factor-alpha | 2000 |
Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.
Topics: Animals; Biological Transport; Calcium; Carcinogens; Cyclic GMP; Dogs; Enzyme Inhibitors; Female; Femoral Artery; Fluorescent Dyes; Free Radical Scavengers; Fura-2; Hypoglycemic Agents; Insulin; Male; Manganese; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase C; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction | 2000 |
Dexamethasone inhibits the induction of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase by phorbol ester in human promonocytic U937 cells.
Topics: Anti-Inflammatory Agents; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Hydroxyprostaglandin Dehydrogenases; Indoles; Maleimides; Mifepristone; Phorbol Esters; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; U937 Cells | 2000 |
Involvement of superoxide generated by polymorphonuclear leukocytes in endotoxin-induced uveitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Male; Neutrophil Activation; Neutrophils; Protein Kinase C; Rats; Rats, Inbred Lew; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Uveitis, Anterior | 2000 |
Rapid dephosphorylation of H1 histones after apoptosis induction.
Topics: Apoptosis; Deoxyribonucleases; DNA Fragmentation; DNA, Neoplasm; Enzyme Activation; Histones; HL-60 Cells; Humans; Marine Toxins; Nucleosomes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Topotecan | 2000 |
Estrogen directly acts on osteoclasts via inhibition of inward rectifier K+ channels.
Topics: Animals; Barium; Calcium; Cells, Cultured; Chelating Agents; Cyclic AMP; Dose-Response Relationship, Drug; Estradiol; Guanosine Diphosphate; Membrane Potentials; Okadaic Acid; Osteoclasts; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Progesterone; Rats; Rats, Wistar; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors | 2000 |
Modulation of neutrophil migration and superoxide anion release by metoprolol.
Topics: Adrenergic beta-Antagonists; Cells, Cultured; Chemotaxis, Leukocyte; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Metoprolol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Differential regulation of microglial NO production by protein kinase C inhibitors.
Topics: Animals; Carbazoles; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Indoles; Isoquinolines; Lipopolysaccharides; Microglia; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Isoforms; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 2001 |
TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway.
Topics: Benzoquinones; Cell Nucleus; Cyclooxygenase 2; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelial Cells; Estrenes; Gene Expression Regulation; Genistein; Humans; I-kappa B Kinase; Isoenzymes; Lactams, Macrocyclic; Lung; Membrane Proteins; Mutagenesis, Site-Directed; NF-kappa B; NF-kappaB-Inducing Kinase; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase C gamma; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrrolidines; Pyrrolidinones; Quinones; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2000 |
PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells.
Topics: Animals; Cell Line; Enzyme Activation; Intermediate Filaments; Melatonin; Mice; Phosphorylation; Protein Kinase C; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Vimentin | 2000 |
Protein kinase A or C modulates the apoptosis induced by lectin II isolated from Korean mistletoe, Viscum album var. Coloratum, in the human leukemic HL-60 cells.
Topics: Apoptosis; Bucladesine; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Indoles; Lectins; Mistletoe; Plant Lectins; Plant Preparations; Plant Proteins; Plants, Medicinal; Protein Kinase C; Pyrroles; Ribosome Inactivating Proteins, Type 2; Staurosporine; Tetradecanoylphorbol Acetate; Toxins, Biological | 2000 |
Two mechanisms of synaptic vesicle recycling in rat brain nerve terminals.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Bacterial Agents; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Glutamic Acid; Macrolides; Potassium Channel Blockers; Potassium Chloride; Presynaptic Terminals; Protein Kinase C; Proton-Translocating ATPases; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Staurosporine; Synaptic Vesicles; Synaptosomes; Tetradecanoylphorbol Acetate; Vacuolar Proton-Translocating ATPases | 2000 |
Role of protein kinase C in alpha(1)-adrenergic regulation of a(Na)(i) in guinea pig ventricular myocytes.
Topics: Adrenergic alpha-Agonists; Animals; Enzyme Inhibitors; Extracellular Space; Guinea Pigs; Heart Ventricles; Indoles; Intracellular Membranes; Maleimides; Myocardium; Phenylephrine; Potassium; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium; Staurosporine; Strophanthidin; Tetradecanoylphorbol Acetate; Tetrodotoxin | 2000 |
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2.
Topics: Animals; Antioxidants; beta-Naphthoflavone; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Hydroquinones; Indoles; Leucine Zippers; NF-E2-Related Factor 2; Oxidative Stress; Phosphorylation; Protein Kinase C; Pyrroles; Rats; Response Elements; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured | 2000 |
Differential localization of protein kinase C isotypes in equine eosinophils and neutrophils.
Topics: Animals; Brain; Cell Membrane; Cell Nucleus; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Horses; Indoles; Intracellular Membranes; Isoenzymes; Maleimides; Neutrophils; Organ Specificity; Protein Kinase C; Rats; Respiratory Burst; Staurosporine; Subcellular Fractions; Superoxides; Tetradecanoylphorbol Acetate | 2000 |
Entamoeba invadens: protein kinase C inhibitors block the growth and encystation.
Topics: Alkaloids; Animals; Benzophenanthridines; Entamoeba; Enzyme Inhibitors; Naphthalenes; Phenanthridines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Modulation of alveolar macrophage phagocytosis by leukotrienes is Fc receptor-mediated and protein kinase C-dependent.
Topics: Acetophenones; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Female; Hydroxyurea; Immune Sera; Immunoglobulin G; Klebsiella pneumoniae; Leukotriene Antagonists; Leukotrienes; Macrophages, Alveolar; Microspheres; Naphthalenes; Phagocytosis; Protein Kinase C; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Fc; Receptors, Leukotriene B4; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Tetrazoles | 2000 |
Activation of dopamine D(1)-like receptor causes phosphorylation of alpha(1)-subunit of Na(+),K(+)-ATPase in rat renal proximal tubules.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cell Line; Dopamine Agonists; Enzyme Inhibitors; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutation; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway.
Topics: Animals; Blotting, Western; Carrier Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Lectins; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Receptors, Cell Surface; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; U937 Cells | 2001 |
Hemicholinium-3 mustard reveals two populations of cycling choline cotransporters in Limulus.
Topics: Alkaloids; Animals; Benzophenanthridines; Binding, Competitive; Biological Transport; Carcinogens; Carrier Proteins; Cell Membrane; Choline; Cholinergic Agents; Cholinergic Fibers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Ganglia, Invertebrate; Hemicholinium 3; Horseshoe Crabs; Male; Membrane Transport Proteins; Phenanthridines; Potassium Chloride; Protein Kinase C; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 2001 |
Characterization of adenylyl cyclases in cultured human granulosa cells.
Topics: Adenylyl Cyclases; Calcimycin; Calcium; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Inhibitors; Female; Granulosa Cells; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoenzymes; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.
Topics: Androstadienes; Apoptosis; Bacterial Proteins; Bacterial Toxins; bcl-X Protein; Biomarkers; Cell Differentiation; Cell Size; DNA Fragmentation; Gene Expression Regulation; Humans; Microtubule-Associated Proteins; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphopyruvate Hydratase; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; rhoA GTP-Binding Protein; Signal Transduction; Staurosporine; Synaptophysin; Tetradecanoylphorbol Acetate; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Wortmannin | 2001 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Down-Regulation; Drug Resistance, Neoplasm; Formazans; Humans; Immunoblotting; Male; Prostatic Neoplasms; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Transfection; Tumor Cells, Cultured | 2001 |
Arginine vasopressin inhibits apoptosis of rat glomerular mesangial cells via V1a receptors.
Topics: Animals; Apoptosis; Arginine Vasopressin; Cells, Cultured; Electrophoresis, Agar Gel; Enzyme-Linked Immunosorbent Assay; Glomerular Mesangium; Kidney Glomerulus; Male; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Nutritional lipid emulsions modulate cellular signaling and activation of human neutrophils.
Topics: Blood; Calcium; Cytosol; Emulsions; Estrenes; Fluorescent Dyes; Fura-2; Humans; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Signal Transduction; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases; Zymosan | 2001 |
Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells.
Topics: Carcinogens; Cells, Cultured; Chloride Channels; Ciliary Body; Down-Regulation; Enzyme Inhibitors; Humans; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pigment Epithelium of Eye; Potassium Channels; Protein Kinase C; Protein Phosphatase 1; Rubidium Radioisotopes; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Protein kinase C regulates transcription of the human guanylate cyclase C gene.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blotting, Western; Catalytic Domain; Cell Line; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Hepatocyte Nuclear Factor 4; Humans; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 2001 |
Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cytochalasin B; Enzyme Inhibitors; Fibrinogen; Genistein; Glutathione Transferase; Humans; In Vitro Techniques; Interleukin-8; Kinetics; Macrophage-1 Antigen; Neutrophil Activation; Neutrophils; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Recombinant Fusion Proteins; src Homology Domains; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates | 2001 |
Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
Topics: Calcineurin; Calcineurin Inhibitors; Calcium Signaling; Capsid; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Herpesvirus 8, Human; Humans; Indoles; Ionomycin; Maleimides; Microscopy, Electron; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; Virus Activation | 2001 |
Follicle-stimulating hormone promotes the growth of human epithelial ovarian cancer cells through the protein kinase C-mediated system.
Topics: Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Female; Follicle Stimulating Hormone; Humans; Isoenzymes; Ovarian Neoplasms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine | 2001 |
Shedding of growth hormone-binding protein is inhibited by hydroxamic acid-based protease inhibitors: proposed mechanism of activation of growth hormone-binding protein secretase.
Topics: Animals; Carrier Proteins; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ethylmaleimide; Humans; Hydroxamic Acids; Metalloendopeptidases; Protein Kinase C; Receptors, Somatotropin; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 2001 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein.
Topics: Animals; Binding Sites; Carrier Proteins; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Activation; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Microscopy, Confocal; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Phosphatidic Acids; Phosphorylation; Protein Kinase C; Recombinant Fusion Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 2001 |
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
Topics: Dimerization; Dynamins; Endocytosis; Epidermal Growth Factor; ErbB Receptors; GTP Phosphohydrolases; HeLa Cells; Humans; Phosphoamino Acids; Phosphorylation; Protein Binding; Receptor, ErbB-2; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Enzyme Activation; Epithelial Cells; Genes, myc; Genes, Retinoblastoma; Humans; Male; Phosphorylation; Prostate; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-myc; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2001 |
Deterioration of the protein kinase C-K(ATP) channel pathway in regulation of coronary flow in hypercholesterolaemic rabbits.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Enzyme Inhibitors; Heart Ventricles; Hypercholesterolemia; In Vitro Techniques; Male; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Kinase C; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Carbachol; Carcinogens; Cell Communication; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Acid; Interleukin-1; Parietal Cells, Gastric; Phenanthridines; Protein Kinase C; Rabbits; Sphingomyelin Phosphodiesterase; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Prevention of staurosporine-induced cell death in embryonic chick cardiomyocyte is more dependent on caspase-2 than caspase-3 inhibition and is independent of sphingomyelinase activation and ceramide generation.
Topics: Animals; Apoptosis; Caspase 2; Caspase 3; Caspase Inhibitors; Ceramides; Chick Embryo; Cysteine Proteinase Inhibitors; Enzyme Activation; Heart; Myocardium; Oligopeptides; Sphingomyelin Phosphodiesterase; Sphingomyelins; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Tumor necrosis factor-alpha is induced through phorbol ester--and glycated human albumin-dependent pathway in THP-1 cells.
Topics: Carcinogens; Catalase; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Insulin Resistance; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase C; Serum Albumin; Signal Transduction; Staurosporine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Effects of protein kinase C inhibitors on insulin secretory responses from rodent pancreatic islets.
Topics: Animals; Carbachol; Carbazoles; Cholinergic Agonists; Colforsin; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glucose; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mice; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
A kainate receptor increases the efficacy of GABAergic synapses.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Benzodiazepines; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Neurons; Protein Kinase C; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Staurosporine; Synapses; Tetradecanoylphorbol Acetate; Tetrodotoxin | 2001 |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase Calpha.
Topics: Adenosine Triphosphate; Blotting, Western; Cell Membrane; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Cytosol; Enzyme Activation; Enzyme Inhibitors; Female; Granulosa Cells; Humans; Indoles; Isoenzymes; Luteal Cells; Maleimides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 2001 |
Activation of protein kinase C increases acetylcholine release from frog motor nerves by a direct action on L-type Ca(2+) channels and apparently not by depolarisation of the terminal.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Enzyme Inhibitors; Motor Neurons; Naphthalenes; Neuromuscular Junction; Nimodipine; Phorbols; Potassium Chloride; Presynaptic Terminals; Protein Kinase C; Rana temporaria; Staurosporine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2001 |
Immunobiology of CD28 expression on human neutrophils. I. CD28 regulates neutrophil migration by modulating CXCR-1 expression.
Topics: Adult; CD28 Antigens; Cells, Cultured; Chemotaxis, Leukocyte; Cross-Linking Reagents; Dactinomycin; Down-Regulation; Flow Cytometry; Gene Expression Regulation; Humans; Interleukin-8; Neutrophil Infiltration; Neutrophils; Receptors, Interleukin-8A; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Uncoupling of ATP-induced inositol phosphate formation and Ca(2+) mobilization by phorbol ester in canine cultured tracheal epithelial cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Cells, Cultured; Dogs; Enzyme Inhibitors; Epithelial Cells; Female; Inositol Phosphates; Male; Protein Kinase C; Protein Transport; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea; Uridine Triphosphate | 2001 |
Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha.
Topics: Astrocytes; Astrocytoma; Carbachol; Carcinogens; Cell Cycle; Cell Division; Cholinergic Agonists; Culture Media, Serum-Free; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Indoles; Isoenzymes; Maleimides; Organometallic Compounds; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils.
Topics: Adjuvants, Immunologic; Basophils; Calcium; Cell Survival; Complement C5a; DNA-Binding Proteins; Humans; Indoles; Interleukin-3; Interleukin-5; Intracellular Fluid; Janus Kinase 2; Leukotriene C4; MAP Kinase Signaling System; Milk Proteins; Nerve Growth Factor; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, IgE; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators | 2001 |
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.
Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Visualizing postendocytic traffic of synaptic vesicles at hippocampal synapses.
Topics: Animals; Buffers; Calcium; Carcinogens; Cell Membrane; Cells, Cultured; Chelating Agents; Egtazic Acid; Endocytosis; Enzyme Inhibitors; Green Fluorescent Proteins; Hippocampus; Indicators and Reagents; Luminescent Proteins; Membrane Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; R-SNARE Proteins; Rats; Staurosporine; Synaptic Vesicles; Synaptophysin; Tetradecanoylphorbol Acetate; Transfection | 2001 |
Effect of interleukin 1, lipopolysaccharide and phorbol esters on phospholipase D activity in chondrocytes.
Topics: Animals; Cattle; Chondrocytes; Dinoprostone; Down-Regulation; Interleukin-1; Lipopolysaccharides; Phospholipase D; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Pulmonary artery vasoconstriction but not [Ca2+]i signal stimulated by thromboxane A2 is partially resistant to NO.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium Signaling; Enzyme Inhibitors; Indoles; Male; Maleimides; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Protein Kinase C; Pulmonary Artery; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Thromboxane A2; Vasoconstriction | 2001 |
Antagonizing effect of protein kinase C activation on the mu-opioid agonist-induced inhibition of high voltage-activated calcium current in rat periaqueductal gray neuron.
Topics: Analgesics, Opioid; Animals; Calcium Channels; Calcium Signaling; Carcinogens; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Female; Male; Membrane Potentials; Neurons; Pain; Periaqueductal Gray; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Staurosporine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2001 |
Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.
Topics: Acetylcysteine; Adenoviridae; Alkaloids; Animals; Animals, Newborn; Annexin A5; Antioxidants; Apoptosis; Benzophenanthridines; Caspases; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Glutathione; Hydrogen Peroxide; Immunoblotting; In Situ Nick-End Labeling; Injections, Intravenous; Microscopy, Fluorescence; Myocardium; Necrosis; Phenanthridines; Protein Isoforms; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Bucladesine; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycosphingolipids; Leishmania donovani; Leishmaniasis, Visceral; Lipopolysaccharides; Macrophages; Mice; Okadaic Acid; Ornithine Decarboxylase; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Inhibition of voltage-gated Ca(2+) current by PACAP in rat adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Chromaffin Cells; Cytosol; Electric Conductivity; In Vitro Techniques; Ion Channel Gating; Male; Neuropeptides; Nicotine; Patch-Clamp Techniques; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
Characterization and regulation of a cloned ovine gastrointestinal peptide transporter (oPepT1) expressed in a mammalian cell line.
Topics: Animals; Carrier Proteins; CHO Cells; Cloning, Molecular; Cricetinae; Dipeptides; DNA, Complementary; Enzyme Inhibitors; Female; Hydrogen-Ion Concentration; Kinetics; Oocytes; Peptide Transporter 1; Protein Kinase C; Sheep; Staurosporine; Symporters; Tetradecanoylphorbol Acetate; Transfection | 2002 |
Effect of protein kinase C on endoplasmic reticulum cholesterol.
Topics: Acetophenones; Benzopyrans; Bryostatins; Calcium; Cell Membrane; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Inhibitors; Fibroblasts; Humans; Lactones; Macrolides; Mitogens; Naphthalenes; Protein Isoforms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.
Topics: Amiloride; Animals; Apoptosis; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; G1 Phase; Hematopoietic Stem Cells; Hydrogen-Ion Concentration; Interleukin-3; Lovastatin; Membrane Lipids; Mice; Monoterpenes; Naphthalenes; Neoplastic Stem Cells; Phosphatidylserines; Phosphorylation; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Resting Phase, Cell Cycle; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 2002 |
Inhibitory effect of menaquinone-7 (vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in rat bone tissues in vitro.
Topics: Animals; Bone and Bones; Bone Marrow Cells; Bone Resorption; Bucladesine; Calcitonin; Calcium; Carcinogens; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Hemostatics; Male; Osteoclasts; Oxytocics; Peptide Fragments; Rats; Rats, Wistar; Staurosporine; Teriparatide; Tetradecanoylphorbol Acetate; Vitamin K 2 | 2001 |
Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Carcinogens; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Protein Transport; Receptors, Retinoic Acid; RNA, Messenger; STAT3 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Tretinoin; Tumor Cells, Cultured | 2002 |
Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP.
Topics: Adenosine Triphosphate; Calcium; Carcinogens; Cell Line; Cell Membrane; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Ionomycin; Ionophores; Isoenzymes; Luminescent Proteins; Magnesium; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Recombinant Fusion Proteins; Saponins; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2002 |
Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Binding Sites; Casein Kinase II; Chlorocebus aethiops; COS Cells; DNA Primers; Enzyme Inhibitors; G-Protein-Coupled Receptor Kinases; Inositol Phosphates; Ligands; Models, Molecular; Polymerase Chain Reaction; Protein Conformation; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Leukotriene B4; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Threonine; Transfection | 2002 |
Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway.
Topics: Adenoma; Adult; Animals; Apoptosis; Carcinoma; Cell Division; DNA Fragmentation; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mice; Middle Aged; Neoplasm Proteins; Pituitary Neoplasms; Protein Kinase C; Signal Transduction; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5.
Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Granulosa Cells; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Protein 5; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
Effect of protein kinase C on multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Colorectal Neoplasms; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Gene Expression Regulation; Humans; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells.
Topics: Adult; Agatoxins; Alkaloids; Benzophenanthridines; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Cell Size; Diglycerides; Dimethyl Sulfoxide; Enzyme Inhibitors; Erythrocytes; Humans; Ion Transport; Ionophores; Marine Toxins; Okadaic Acid; Osmotic Fragility; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Protein Kinase C; Spider Venoms; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Inhibition of prostaglandin E(2) production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action.
Topics: Animals; Arachidonic Acid; Araliaceae; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Lactones; Lignans; Macrophages, Peritoneal; Male; Membrane Proteins; Plant Roots; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 2002 |
Mechanisms of regulation of phospholipase D1 by protein kinase Calpha.
Topics: Animals; Binding Sites; Catalytic Domain; Cloning, Molecular; COS Cells; Enzyme Activation; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation, Enzymologic; Isoenzymes; Mutation; Phospholipase D; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Protein Structure, Tertiary; Rats; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2003 |
Cholinergic activation of glucose transport in bovine chromaffin cells involves calmodulin and protein kinase Czeta signaling.
Topics: Acetylcholine; Androstadienes; Animals; Biological Transport; Blotting, Northern; Calmodulin; Cattle; Cholinergic Agonists; Chromaffin Cells; Down-Regulation; Enzyme Inhibitors; Genistein; Glucose; Mitogen-Activated Protein Kinases; Models, Biological; Mutagens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2002 |
Effect of protein kinase C activation on Na+-H+ exchange in erythrocytes of frog Rana temporaria.
Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Biological Transport; Carcinogens; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Phosphoprotein Phosphatases; Protein Kinase C; Rana temporaria; Sodium; Sodium Fluoride; Sodium Radioisotopes; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Involvement of protein kinase C in glutamate release from cultured microglia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, Cultured; Glutamic Acid; Kinetics; Lipopolysaccharides; Microglia; Nitroarginine; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Indoles; Isoenzymes; Mice; Molecular Mimicry; Monosaccharide Transport Proteins; Muscle Proteins; Oligopeptides; Peptides; Protein Kinase C; Protein Kinase C beta; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Modulation of gap junction mediated intercellular communication in TM3 Leydig cells.
Topics: Animals; Biological Transport; Bucladesine; Cell Adhesion; Cell Line; Cell Membrane; Coloring Agents; Connexin 43; Enzyme Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Glyceraldehyde-3-Phosphate Dehydrogenases; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mice; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation.
Topics: Actins; Alkaloids; Animals; Benzophenanthridines; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; In Vitro Techniques; Indoles; Liver; Male; Maleimides; Phenanthridines; Phorbol Esters; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Angiotensin II-induced ionic currents and signalling pathways in submandibular ganglion neurons.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cricetinae; Enzyme Inhibitors; GTP-Binding Proteins; Ion Channels; Neurons, Afferent; Patch-Clamp Techniques; Protein Kinase C; Signal Transduction; Staurosporine; Submandibular Gland; Tetradecanoylphorbol Acetate | 2003 |
Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis.
Topics: Androstenedione; Animals; Cells, Cultured; Colforsin; Cordyceps; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydroxycholesterols; Isoquinolines; Leydig Cells; Male; Mice; Mice, Inbred C57BL; Mycelium; Progestins; Protein Kinase C; Staurosporine; Sulfonamides; Testosterone; Tetradecanoylphorbol Acetate | 2003 |
Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA; Female; Hematopoiesis; Humans; K562 Cells; Megakaryocytes; Mice; Microtubule Proteins; Phosphoproteins; Polyploidy; Stathmin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Phorbol ester stimulates expression of the human tryptophanyl-tRNA synthetase gene.
Topics: Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Interferon-gamma; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tryptophan-tRNA Ligase | 2003 |
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; CD4-Positive T-Lymphocytes; Cell Death; Cells, Cultured; Conserved Sequence; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Endopeptidases; Etoposide; fas Receptor; Fas-Associated Death Domain Protein; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Peptide Fragments; Protein Structure, Tertiary; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2003 |
Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.
Topics: Amino Acid Sequence; Animals; Blotting, Western; COS Cells; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Metalloendopeptidases; Mice; Models, Biological; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Protease Inhibitors; Protein Kinase C; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels?
Topics: Animals; Anions; Carbachol; Cell Line; Enzyme Activation; Genetic Vectors; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Phospholipids; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Kinase C; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 2003 |
Cytometric analysis of protein expression and apoptosis in human primary cells with a novel microfluidic chip-based system.
Topics: Apoptosis; CD3 Complex; Cells, Cultured; E-Selectin; Endothelium, Vascular; Fibroblasts; Flow Cytometry; Humans; Interleukin-1; Lymphocytes; Microchemistry; Protein Biosynthesis; Software; Staining and Labeling; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
In vitro anti-inflammatory and pro-aggregative effects of a lipid compound, petrocortyne A, from marine sponges.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Autocrine Communication; Cell Adhesion Molecules; Cell Aggregation; Cell Differentiation; Cell Line; Fatty Alcohols; Genistein; Hepatocyte Growth Factor; Humans; Insulin-Like Growth Factor II; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; Phosphorylation; Polymers; Polyynes; Porifera; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
Exocytosis of a complement component C3-like protein by tunicate hemocytes.
Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcimycin; Carrageenan; Cell Survival; Cholera Toxin; Colchicine; Colforsin; Complement C3; Cytochalasin D; Cytoplasmic Vesicles; Enzyme-Linked Immunosorbent Assay; Exocytosis; Hemocytes; Immunohistochemistry; Kinetics; Lipopolysaccharides; Mannans; Microscopy, Electron; Phenanthridines; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Urochordata | 2004 |
Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction.
Topics: Amino Acid Sequence; Animals; Cytosol; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Green Fluorescent Proteins; Hydrolysis; Luminescent Proteins; Microscopy, Confocal; Molecular Sequence Data; Mutagenesis; Naphthalenes; Oocytes; Osmosis; Phosphatidylinositol 4,5-Diphosphate; Point Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Rabbits; RNA, Complementary; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Xenopus; Xenopus laevis | 2004 |
Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells).
Topics: Animals; Cell Line; Cytochalasin D; Enzyme Inhibitors; Genistein; Macrophages; Mice; Nucleic Acid Synthesis Inhibitors; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation; Cyclooxygenase 1; Cyclooxygenase 2; Cytochalasin B; Dinoprostone; Edema; Female; Gastric Mucosa; Gene Expression; Genistein; Hindlimb; Humans; Indomethacin; Isoenzymes; Korea; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Medicine, East Asian Traditional; Membrane Proteins; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatic Elastase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plant Extracts; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Staurosporine; Stomach; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2004 |
Inhibition of platelet adherence to mononuclear cells by alpha-tocopherol: role of P-selectin.
Topics: Administration, Oral; Adult; alpha-Tocopherol; Blood Platelets; Enzyme Inhibitors; Humans; Leukocytes, Mononuclear; P-Selectin; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 2004 |
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate | 2004 |
Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.
Topics: Boron Compounds; Calcium; Calcium Channel Blockers; Cytosol; Dantrolene; Dose-Response Relationship, Drug; Estrenes; Fatty Alcohols; Glycols; HeLa Cells; Humans; Imidazoles; Indoles; Intracellular Space; Maleimides; Nickel; Nifedipine; Plasmids; Propranolol; Protein Kinase Inhibitors; Pyrrolidinones; Receptors, Leukotriene B4; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection | 2004 |
Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C.
Topics: Amiloride; Animals; Arachidonic Acids; Brefeldin A; Cytochrome P-450 Enzyme System; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Kidney Cortex; Kinetics; Male; Models, Biological; Nocodazole; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate | 2004 |
Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
Topics: Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2E1; Glutathione; Humans; Indoles; Iron; Lipid Peroxidation; Maleimides; Oxidative Stress; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
Adenylyl cyclase-cAMP system inhibits thrombin-induced HSP27 in vascular smooth muscle cells.
Topics: Adenine; Adenylyl Cyclases; Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; DNA Primers; Heat-Shock Proteins; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 2005 |
Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring.
Topics: Apoptosis; Cell Differentiation; Cell Line, Tumor; Diosgenin; Fractionation, Field Flow; Humans; Leukemia, Erythroblastic, Acute; Staurosporine; Tetradecanoylphorbol Acetate | 2004 |
Sphingosine 1-phosphate breakdown in platelets.
Topics: Blood Platelets; Cell Membrane; Ceramides; Chromatography, High Pressure Liquid; Humans; Lysophospholipids; Models, Biological; Phosphatidate Phosphatase; Phosphorylation; Platelet Activation; Platelet Aggregation; Signal Transduction; Sphingolipids; Sphingomyelins; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors | 2004 |
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Bradykinin; Cell Line, Tumor; Cell Membrane; COS Cells; Cytoplasm; Cytosol; Diacylglycerol Kinase; DNA, Complementary; Glutathione Transferase; Glycerol; Green Fluorescent Proteins; GTP-Binding Proteins; Humans; Kinetics; Microscopy, Confocal; Models, Biological; Mutation; Norepinephrine; Peptides; Phosphorylation; Point Mutation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Thrombin; Time Factors; Transcriptional Activation | 2005 |
Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells.
Topics: Alkaloids; Antineoplastic Agents; Benzophenanthridines; Capsaicin; Carboxylesterase; Carcinogens; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia, Myeloid; Macrophages; Models, Chemical; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Mitochondrial K(ATP) channels in respiratory neurons and their role in the hypoxic facilitation of rhythmic activity.
Topics: Animals; Animals, Newborn; Calcium; Cell Hypoxia; Decanoic Acids; Diazoxide; Enzyme Inhibitors; Fluorescent Antibody Technique; Fluorescent Dyes; Hydroxy Acids; In Vitro Techniques; Medulla Oblongata; Mice; Mitochondria; Neurons; Periodicity; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Respiration; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
PKCalpha is involved in phorbol ester TPA-mediated stabilization of p14ARF.
Topics: Butadienes; Cell Line, Tumor; Doxycycline; Genes, p53; Humans; Leupeptins; Lovastatin; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Nitriles; Proteasome Inhibitors; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p14ARF | 2005 |
Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Clone Cells; Cyclic AMP-Dependent Protein Kinases; Drug Combinations; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Opossums; Parathyroid Hormone; Protein Kinase C; Sodium-Phosphate Cotransporter Proteins; Staurosporine; Symporters; Tetradecanoylphorbol Acetate | 2005 |
Phytoestrogens modulate prostaglandin production in bovine endometrium: cell type specificity and intracellular mechanisms.
Topics: Animals; Cattle; Dactinomycin; Endometrium; Epithelial Cells; Estradiol; Estrenes; Female; Glycine max; Oxytocin; Phytoestrogens; Prostaglandins; Pyrrolidinones; Staurosporine; Stromal Cells; Tetradecanoylphorbol Acetate | 2005 |
Glycoprotein isolated from Solanum nigrum L. modulates the apoptotic-related signals in 12-O-tetradecanoylphorbol 13-acetate-stimulated MCF-7 cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; DNA Fragmentation; Enzyme Inhibitors; Glycoproteins; Humans; NF-kappa B; Plant Proteins; Protein Kinase C; Protein Kinase C-alpha; Pyrrolidines; Solanum nigrum; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
The role of calcium desensitization in vascular hyporeactivity and its regulation after hemorrhagic shock in the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Vessels; Calcium; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Indoles; Insulin; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Oxazoles; Perfusion; Protein Kinase Inhibitors; Rats; Rats, Wistar; Shock, Hemorrhagic; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
Cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors.
Topics: Apoptosis; Calcimycin; Calcium; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Chelating Agents; Colorectal Neoplasms; Cycloheximide; Dactinomycin; Drug Synergism; Edetic Acid; Egtazic Acid; Enzyme Activation; Enzyme Activators; Humans; Ionophores; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Escape; Tumor Necrosis Factor-alpha | 2005 |
The effect of PKC activity on the TTX-R sodium currents from rat nodose ganglion neurons.
Topics: Animals; Animals, Newborn; Enzyme Activators; Enzyme Inhibitors; Kinetics; Membrane Potentials; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Wistar; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Tetrodotoxin | 2005 |
Role of protein kinase C in expression of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Apoptosis; Enzyme Activation; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoenzymes; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2005 |
Na+/Mg2+ antiport in erythrocytes of spontaneously hypertensive rats: role of Mg2+ in the pathogenesis of hypertension.
Topics: Animals; Biological Transport; Blood Pressure; Enzyme Inhibitors; Erythrocytes; Hypertension; Magnesium; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement.
Topics: Alkaloids; Anesthetics, Intravenous; Animals; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etomidate; Excitatory Amino Acid Transporter 3; Female; Glutamic Acid; Ketamine; Membrane Potentials; Oocytes; Phenanthridines; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thiopental; Xenopus | 2006 |
Protein kinase C-mediated endothelial barrier regulation is caveolin-1-dependent.
Topics: Animals; Cadherins; Caveolin 1; Cell Adhesion; Cells, Cultured; Dextrans; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Gap Junctions; Immunoblotting; Immunohistochemistry; Lasers; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 2006 |
Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells.
Topics: Animals; Apoptosis; beta Catenin; Bone and Bones; Bone Development; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Enzyme Inhibitors; Etoposide; Gene Expression Regulation; Isoquinolines; Lithium Chloride; Luciferases; Mice; Naphthalenes; NIH 3T3 Cells; Osteoblasts; Parathyroid Hormone; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad3 Protein; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Transforming Growth Factor beta | 2006 |
Equol and para-ethyl-phenol stimulate prostaglandin F(2alpha) secretion in bovine corpus luteum: intracellular mechanisms of action.
Topics: Animals; Calcium; Cattle; Cells, Cultured; Corpus Luteum; Dactinomycin; Diet; Dinoprost; Equol; Estrenes; Female; Glycine max; Isoflavones; Luteinizing Hormone; Phenols; Phytoestrogens; Pyrrolidinones; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2006 |
Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.
Topics: Animals; Benzo(a)pyrene; Blotting, Western; Cell Survival; Electrophoretic Mobility Shift Assay; Endothelial Cells; Endothelium, Vascular; Enzyme Activators; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Phosphorylation; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 2006 |
Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells.
Topics: Acetophenones; Action Potentials; Adenoma; Animals; Benzopyrans; Carcinogens; Cell Line; Cell Line, Tumor; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Neurons; Pituitary Neoplasms; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C-delta; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 2007 |
Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity: evidence of protein kinase C involvement.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 3; Neuroprotective Agents; Oxidative Stress; Propofol; Protein Kinase C; Rats; Staurosporine; tert-Butylhydroperoxide; Tetradecanoylphorbol Acetate; Xenopus | 2007 |
Protein kinase C activity in mouse eggs regulates gamete membrane interaction.
Topics: Actins; Animals; Antibodies, Monoclonal; Antigens, CD; Cell Membrane; Cytoskeleton; Male; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Microvilli; Naphthalenes; Ovum; Protein Kinase C; Protein Kinase Inhibitors; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Tetraspanin 29 | 2007 |
Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.
Topics: Animals; Carcinogens; Cells, Cultured; Dimerization; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hepatocyte Nuclear Factor 1-beta; Humans; Inflammation; MafG Transcription Factor; Male; Mutation; Naphthalenes; Nitric Oxide Synthase Type II; Protein Kinase C; Rats; Rats, Sprague-Dawley; Repressor Proteins; Response Elements; RNA, Small Interfering; Signal Transduction; Smad6 Protein; Smad7 Protein; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2007 |
Isoform-specific translocation of PKC isoforms in NIH3T3 cells by TPA.
Topics: Animals; Cell Compartmentation; Cell Membrane; Cytoplasm; Enzyme Activation; Golgi Apparatus; Green Fluorescent Proteins; Isoenzymes; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; Protein Kinase C; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2007 |
Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C.
Topics: Benzophenanthridines; Cell Line, Tumor; Enzyme Inhibitors; Humans; Naphthalenes; Neoplasm Invasiveness; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin | 1997 |
Emodin increases Ca(2+) influx through L-type Ca(2+) channel in guinea pig gallbladder smooth muscle.
Topics: Animals; Calcium Channel Agonists; Calcium Channels, L-Type; Calcium Signaling; Dose-Response Relationship, Drug; Emodin; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2008 |
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
Topics: Animals; Apoptosis; Aspartic Acid; Calcimycin; Hydrogen Peroxide; Hypotonic Solutions; Ion Channels; Ionophores; Nitrobenzoates; PC12 Cells; Rats; Sphingosine; Staurosporine; Stereoisomerism; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uric Acid | 2009 |
Calcium homeostasis and its relationship to superoxide production in blood and milk neutrophils of lactating goats.
Topics: Animals; Apoptosis; Calcium; Female; Goats; Homeostasis; Immunity, Innate; In Vitro Techniques; Ionomycin; Ionophores; Lactation; Mammary Glands, Animal; Milk; Neutrophils; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 2010 |
Modulation of single-channel properties of TRPV1 by phosphorylation.
Topics: Algorithms; Capsaicin; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Enzyme Activation; HEK293 Cells; Humans; Ion Channel Gating; Kinetics; Nerve Growth Factor; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; TRPV Cation Channels | 2010 |
Mechanism of hCG-induced spermiation in the toad Rhinella arenarum (Amphibia, Anura).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Bufo arenarum; Chorionic Gonadotropin; Cyclic AMP-Dependent Protein Kinases; Indoles; Isoquinolines; Male; Maleimides; Ouabain; Protein Kinase C; Sertoli Cells; Sodium-Potassium-Exchanging ATPase; Spermatozoa; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 2010 |
Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk.
Topics: Cell Line, Transformed; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enzyme Activation; Fenoldopam; Gene Expression; Humans; Kidney; NADPH Oxidases; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Dopamine D1; RNA, Small Interfering; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2011 |
Luteinizing hormone (LH) acts through PKA and PKC to modulate T-type calcium currents and intracellular calcium transients in mice Leydig cells.
Topics: Animals; Benzophenanthridines; Calcium; Calcium Channels, T-Type; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Electrophysiological Phenomena; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mice; Peptides; Protein Kinase C; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 2011 |
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Anticarcinogenic Agents; Benzopyrans; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Oleanolic Acid; Precursor Cells, B-Lymphoid; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2012 |
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.
Topics: Animals; Arachidonic Acid; Brain Neoplasms; Calcium; Cell Line, Tumor; Glioma; Histamine; Inositol Phosphates; Pyrilamine; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2013 |
Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckβ promoter via the protein kinase C signaling pathway.
Topics: Base Sequence; Cell Line, Tumor; Choline Kinase; CpG Islands; GATA Transcription Factors; Humans; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Protein c-ets-1; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2014 |
Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation.
Topics: Catecholamines; Cell Differentiation; Cell Line, Tumor; Humans; Neuroblastoma; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin | 2015 |
Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway.
Topics: Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; E-Selectin; Gene Knockdown Techniques; Genes, fos; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Mechanistic Target of Rapamycin Complex 2; Protein Kinase C; Rapamycin-Insensitive Companion of mTOR Protein; Regulatory-Associated Protein of mTOR; RNA, Small Interfering; Signal Transduction; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate | 2018 |
STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation.
Topics: Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Herpesvirus 8, Human; Humans; Phosphorylation; STAT3 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Virus Activation | 2019 |