staurosporine has been researched along with staurosporine aglycone in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (4.67) | 18.7374 |
| 1990's | 81 (75.70) | 18.2507 |
| 2000's | 16 (14.95) | 29.6817 |
| 2010's | 4 (3.74) | 24.3611 |
| 2020's | 1 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, BA; Brooks, HB; Campbell, RM; Considine, E; DeHahn, TB; Dempsey, JA; Faul, MM; Kumrich, CA; Li, T; Ogg, CA; Paal, M; Patel, BK; Sanchez-Martinez, C; Schultz, RM; Shih, C; Somoza, C; Spencer, CD; Wagner, J; Watkins, SA; Winneroski, LL; Xun, Z; Zhu, G | 1 |
| Argentieri, R; Cavender, D; Chen, X; Malaviya, R; Murray, WV; Wang, B; Wilson, LJ; Yang, C | 1 |
| Decker, SJ; Ohmichi, M; Pang, L; Saltiel, AR | 1 |
| Glass, DJ; Hantzopoulos, P; Ip, NY; Lindsay, NS; Macchi, MJ; Nye, SH; Squinto, SP; Stitt, TN; Yancopoulos, GD | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Dieter, P; Duyster, J; Fitzke, E; Schulze-Specking, A | 1 |
| Nakano, H; Tamaoki, T | 1 |
| Gutman, Y; Zilberman, Y | 1 |
| Abe, K; Saito, H; Takayanagi, M | 1 |
| Keller, H; Zimmermann, A | 1 |
| Bradbury, EM; Crissman, HA; Gadbois, DM; Tobey, RA | 1 |
| Ikeda, E; Mitsuzawa, H; Uno, I; Yoshida, S | 1 |
| Isono, K; Koshino, H; Kudo, T; Onose, R; Osada, H | 1 |
| Isono, K; Kurisaki, T; Magae, J; Nagai, K; Yamasaki, M | 1 |
| Beck, KD; Burton, LE; Hefti, F; Kaplan, DR; Knüsel, B; Nikolics, K; Rabin, S; Rosenthal, A; Winslow, JW | 1 |
| Gschwendt, M; Kittstein, W; Leibersperger, H; Marks, F | 1 |
| Hanna, N; Mong, S; White, JR; Zembryki, D | 1 |
| Cleaveland, JS; Hammond, DJ; Kiener, PA; Schacter, BZ | 1 |
| Kikkawa, U; Koide, H; Nishizuka, Y; Ogita, K | 1 |
| Kessler, DS; Levy, DE | 1 |
| Abe, K; Iri, Y; Saito, H; Takayanagi, M | 1 |
| Apgar, JR | 1 |
| de Médicis, R; Gilbert, C; Grimard, M; Lussier, A; Naccache, PH; Poubelle, PE; Roberge, CJ | 1 |
| Hefti, F; Knüsel, B | 1 |
| Isosaki, M; Kurogochi, Y; Nakashima, T | 1 |
| Buchholz, RA; Cumiskey, WR; Dundore, RL; Harris, AL; Silver, PJ | 1 |
| Bishop, WR; Pachter, JA; Pai, JK; Weinstein, IB | 1 |
| Braquet, P; Ferber, E; Fischer, G; Harell, T; Her, E; Naor, Z; Reiss, N; Zor, U | 1 |
| Behnisch, T; Kase, H; Matthies, H; Reymann, KG | 1 |
| Hannigan, GE; Williams, BR | 1 |
| Perlman, RL; Ruzicka, LA; Tischler, AS | 1 |
| Dale, MM; Muid, RE; Twomey, B | 1 |
| Dale, MM; Muid, RE; Nixon, JS; Sedgwick, AD; Twomey, B; Wilkinson, SE | 1 |
| Levine, L | 1 |
| August, J; Bishop, WR; Pai, JK; Petrin, JM | 1 |
| Jikoh, Y; Nishio, H; Okugawa, K; Segawa, T | 1 |
| Davis, PD; Elliott, LH; Hill, CH; Lawton, G; Nixon, JS; Sedgwick, AD; Wilkinson, SE | 1 |
| Herbert, JM; Maffrand, JP; Seban, E | 1 |
| Kobayashi, S; Kurosawa, M; Okayama, Y | 1 |
| White, JR; Zembryki, D | 1 |
| Davis, PD; Hill, CH; Keech, E; Lawton, G; Nixon, JS; Sedgwick, AD; Wadsworth, J; Westmacott, D; Wilkinson, SE | 1 |
| Burgess, GM; Rüegg, UT | 1 |
| Easom, RA; Hughes, JH; Landt, M; McDaniel, ML; Turk, J; Wolf, BA | 1 |
| Barger, SW; Cheng, B; Mattson, MP | 1 |
| Dauer, WT; Fink, JS; Hamill, LK; Hyman, SE; Lewis, SE; Schwarzschild, MA | 1 |
| Larsen, PM; Wolniak, SM | 1 |
| Azuma, Y; Ishimura, Y; Kizaki, H; Onishi, Y; Suzuki, K | 1 |
| Abraham, I; McCroskey, MC; Sampson, KE | 1 |
| Furukawa, T; Maeda, Y | 1 |
| Connors, TJ; Hudkins, R; Knight, E; Maroney, AC; Neff, N | 1 |
| Ghisalba, O; Goeke, K; Hoehn, P | 1 |
| Basu, U; Bennett, GS; Hollander, BA; Quintana, R; Rodriguez, R | 1 |
| Goodman, Y; Mattson, MP | 1 |
| Abraham, I; Aristoff, PA; Laborde, AL; Sampson, KE; Shelly, JA; Skulnick, HI; Wolf, CL | 1 |
| Ando, M; Mori, T; Takagi, K | 1 |
| Isosaki, M; Minami, N; Nakashima, T | 1 |
| Fabre, S; Prudhomme, M; Sancelme, M | 1 |
| Abraham, I; Sampson, KE; Wolf, CL | 1 |
| Nakashio, A; Shibata, S; Ueki, S; Watanabe, S | 1 |
| Matsuda, Y | 1 |
| Bonser, RW; Randall, RW; Spacey, GD | 1 |
| Mizuno, K; Ohno, S; Saido, TC; Suzuki, K; Tamaoki, T | 1 |
| Ishikawa, Y; Ogawa, A; Sasakawa, S | 1 |
| Beppu, T; Hong, SK; Horinouchi, S; Matsumoto, A | 1 |
| Fleck, T; Huwiler, A; Ochsner, M; Pfeilschifter, J | 1 |
| Kitamura, Y; Miyazaki, A; Nomura, Y | 1 |
| Dasgupta, M; Forbes, ME; Glicksman, MA; Lewis, ME; Meyer, SL; Neff, N; Prantner, JE | 1 |
| Maurer, JA; McKay, DB; Wenger, BW | 1 |
| Akin, D; Feldherr, C | 1 |
| Campbell, XZ; Neet, KE | 1 |
| Djakiew, D; Zolfaghari, A | 1 |
| Friedman, L; Lazarovici, P; Matsuda, Y; Ovadia, H; Rasouly, D; Tabekman, R | 1 |
| Herth, C; Mairbäurl, H | 1 |
| Cao, YZ; Hildenbrandt, GR; Reddy, CC; Reddy, PV; Sordillo, LM | 1 |
| Cai, Y; Fredenhagen, A; Hug, P; Peter, HH | 1 |
| Dickens, G; Guroff, G; Lavarreda, M; Zheng, WH | 1 |
| Baxter, GT; Coit, D; Feinstein, SC; Hinkle, B; Hoang, R; Kuo, RC; Makrides, V; Medina-Selby, A; Radeke, MJ; Valenzuela, P | 1 |
| Benndorf, R; Hayess, K | 1 |
| Goretzki, L; Mueller, BM | 1 |
| Agranoff, BW; Heacock, AM | 1 |
| Arioka, M; Kitamoto, K; Kouhashi, M; Takatsuki, A; Yamasaki, M; Yoda, K | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Brodie, C; Lazarovici, P; Matsuda, Y; Ovadia, H; Tabakman, R | 1 |
| Comolli, JC; Hastings, JW | 1 |
| Arase, Y; Chen, Z; Hiwasa, T; Ito, H; Kita, K; Suzuki, N; Umezawa, K | 1 |
| Bilsland, J; Broughton, H; Ellis, S; Harper, S; Hefti, F; Pollack, S; Wilkie, N; Young, L | 1 |
| Ohuchi, K; Yamaki, K | 1 |
| Koppal, T; Lukas, TJ; Mirzoeva, S; Petrova, TV; Van Eldik, LJ; Watterson, DM | 1 |
| Dudler, R; Freydl, E; Granado, J; Hassa, P; Wäspi, U | 1 |
| Courtois, G; Israël, A; Schwamborn, K; Weil, R; Whiteside, ST | 1 |
| Appleyard, SM; Chavkin, C; Pattillo, A; Rogalski, SL; Terman, GW | 1 |
| Birdsall, NJ; Lazareno, S; Popham, A | 1 |
| Fujikawa-Yamamoto, K; Ikeda, T; Murano, H; Ohdoi, C; Wang, S; Yamagishi, H | 1 |
| Kurihara, K; Moore-Hoon, ML; Nakanishi, N; Turner, RJ | 1 |
| Ramonell, K; Somerville, S; Stacey, G; Zhang, B | 1 |
| Kristjánsdóttir, K; Rudolph, J | 1 |
| Kim, YJ; Lee, SI; Moon, SJ; Seo, JT; Seo, SR; Shin, DM; Sugiya, H | 1 |
| Blatt, MR; Garcia-Mata, C; Gay, R; Hills, A; Lamattina, L; Sokolovski, S | 1 |
| Nagasaki, H; Orito, K; Tokuda, M; Wada, Y | 1 |
| Fujikawa-Yamamoto, K; Miyagoshi, M; Yamagishi, H | 1 |
| Iyer, GH; Pazhanisamy, S; Taslimi, P | 1 |
| Chen, CY; Chen, YL; Chiu, HT; Jin, C; Lee, MN; Lin, YC | 1 |
| Asamizu, S; Igarashi, Y; Nagano, S; Onaka, H; Shiro, Y | 1 |
| Gershburg, E; Gershburg, S; Goswami, R; Satorius, A | 1 |
| Courts, C; Gallala, H; Janzen, V; Kraus, D; Nowak, M; Perner, S; Probstmeier, R; Veit, N; Winter, J | 1 |
| Guan, H; Li, Y; Liu, N; Tan, H; Zhang, J; Zheng, J | 1 |
| Fan, SR; Lan, R; Lang, XY; Qin, XY; Ren, TT; Yu, Y | 1 |
4 review(s) available for staurosporine and staurosporine aglycone
| Article | Year |
|---|---|
Potent and specific inhibitors of protein kinase C of microbial origin.
Topics: Alkaloids; Bacteria; Carbazoles; Fungi; Indole Alkaloids; Naphthalenes; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine | 1990 |
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
Topics: Alkaloids; Animals; Carbazoles; Humans; Indole Alkaloids; Protein Kinase C; Staurosporine | 1989 |
[Protein kinase inhibitors].
Topics: Alkaloids; Animals; Carbazoles; Cell Differentiation; Cell Division; Hormones; Humans; Indole Alkaloids; Muscle Contraction; Neurotransmitter Agents; Nocardia; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proteins; Staurosporine | 1993 |
K252a and staurosporine microbial alkaloid toxins as prototype of neurotropic drugs.
Topics: Animals; Carbazoles; Enzyme Inhibitors; Humans; Indole Alkaloids; Mice; Nervous System; Protein Kinase C; Staurosporine | 1996 |
103 other study(ies) available for staurosporine and staurosporine aglycone
| Article | Year |
|---|---|
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
Topics: Antineoplastic Agents; Carbazoles; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Humans; Proto-Oncogene Proteins; Pyrroles | 2003 |
Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.
Topics: Animals; Cyclization; Drug Evaluation, Preclinical; Hypersensitivity; Janus Kinase 3; Mast Cells; Mice; Phosphorylation; Protein Kinase Inhibitors; STAT5 Transcription Factor; Staurosporine; Structure-Activity Relationship; T-Lymphocytes | 2009 |
Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase.
Topics: Alkaloids; Carbazoles; Cell Line, Transformed; Humans; Indole Alkaloids; Nerve Growth Factors; Oncogene Proteins; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.
Topics: 3T3 Cells; Alkaloids; Animals; Carbazoles; Growth Substances; Indole Alkaloids; Mice; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine | 1992 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Protein kinase C involved in zymosan-induced release of arachidonic acid and superoxide but not in calcium ionophore-elicited arachidonic acid release or formation of prostaglandin E2 from added arachidonate.
Topics: Alkaloids; Animals; Arachidonic Acids; Blotting, Western; Calcimycin; Carbazoles; Cells, Cultured; Dinoprostone; Indole Alkaloids; Kupffer Cells; Male; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Multiple effects of staurosporine, a kinase inhibitor, on thymocyte functions. Comparison with the effect of tyrosine kinase inhibitors.
Topics: Alkaloids; Animals; Benzylidene Compounds; Calcimycin; Carbazoles; Cell Division; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Indole Alkaloids; Mice; Mice, Inbred BALB C; Nitriles; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Tyrphostins | 1992 |
Neurotrophic effects of epidermal growth factor on cultured brain neurons are blocked by protein kinase inhibitors.
Topics: Alkaloids; Animals; Brain; Carbazoles; Cell Survival; Cells, Cultured; Epidermal Growth Factor; Indole Alkaloids; Neurons; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine | 1992 |
Effects of staurosporine, K 252a and other structurally related protein kinase inhibitors on shape and locomotion of Walker carcinosarcoma cells.
Topics: Alkaloids; Animals; Carbazoles; Carcinoma 256, Walker; Cell Movement; Indole Alkaloids; Protein Kinase C; Staurosporine; Structure-Activity Relationship | 1992 |
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
Topics: Alkaloids; Carbazoles; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Humans; In Vitro Techniques; Indole Alkaloids; Indoles; Interphase; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Staurosporine | 1992 |
Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1.
Topics: Alkaloids; Alleles; Calcium Chloride; Carbazoles; Cloning, Molecular; DNA, Fungal; Escherichia coli; Genes, Fungal; Genetic Complementation Test; Genotype; Homozygote; Indole Alkaloids; Neomycin; Plasmids; Protein Kinase C; Saccharomyces cerevisiae; Staurosporine; Temperature | 1992 |
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.
Topics: Alkaloids; Carbazoles; G2 Phase; Indole Alkaloids; Protein Kinase C; Staurosporine; Streptomyces | 1992 |
Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules.
Topics: Alkaloids; Antifungal Agents; Carbazoles; CD4 Antigens; Down-Regulation; Ethers, Cyclic; Indole Alkaloids; Okadaic Acid; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrans; Receptors, Transferrin; Spiro Compounds; Staurosporine | 1992 |
K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Indole Alkaloids; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurons, Afferent; Neurotrophin 3; Pheochromocytoma; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Rats; Receptor, trkA; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1992 |
Protein kinase C zeta and eta in murine epidermis. TPA induces down-regulation of PKC eta but not PKC zeta.
Topics: Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Cytosol; Down-Regulation; Epidermis; Female; Immunoblotting; Indole Alkaloids; Isoenzymes; Mice; Molecular Sequence Data; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Differential inhibition of histamine release from mast cells by protein kinase C inhibitors: staurosporine and K-252a.
Topics: Alkaloids; Animals; Antibodies, Anti-Idiotypic; Carbazoles; Dinoprostone; Enzyme Activation; Histamine Release; Immunoglobulin E; Indole Alkaloids; Male; Mast Cells; Mice; Mice, Inbred CBA; Molecular Weight; p-Methoxy-N-methylphenethylamine; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; SRS-A; Staurosporine | 1990 |
A microtiter-based assay for the detection of protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaloids; Antibodies; Autoanalysis; Binding, Competitive; Carbazoles; Enzyme Stability; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Indole Alkaloids; Muramidase; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 1990 |
Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain.
Topics: Alkaloids; Amino Acid Sequence; Animals; Arachidonic Acid; Brain; Calcium; Carbazoles; Cells, Cultured; Chlorocebus aethiops; Enzyme Activation; Gene Expression; Indole Alkaloids; Kinetics; Male; Molecular Sequence Data; Peptides; Phospholipids; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; RNA, Messenger; Staurosporine; Substrate Specificity | 1992 |
Protein kinase activity required for an early step in interferon-alpha signaling.
Topics: Alkaloids; Carbazoles; DNA-Binding Proteins; HeLa Cells; Humans; Indole Alkaloids; Interferon-alpha; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, alpha Subunit; Interferon-Stimulated Gene Factor 3, gamma Subunit; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1991 |
Involvement of protein kinase activation in neurotrophic effects of basic fibroblast growth factor in cultured brain neurons.
Topics: Alkaloids; Animals; Carbazoles; Cell Survival; Cells, Cultured; Cerebellum; Corpus Striatum; Enzyme Activation; Fibroblast Growth Factor 2; Hippocampus; Indole Alkaloids; Neurons; Protein Kinase Inhibitors; Protein Kinases; Rats; Staurosporine | 1991 |
Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C.
Topics: Actins; Alkaloids; Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Calcium; Carbazoles; Cell Line; Diglycerides; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macromolecular Substances; Protein Kinase C; Rats; Receptors, Fc; Receptors, IgE; Serotonin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Topics: Alkaloids; Calcium; Calcium Pyrophosphate; Carbazoles; Cholera Toxin; Colchicine; Crystallization; Cytochalasin B; Cytoplasm; Diacylglycerol Kinase; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indole Alkaloids; Neutrophils; Oxidation-Reduction; Pertussis Toxin; Phosphotransferases; Protein Kinase C; Pyrimidinones; Staurosporine; Superoxides; Thiazoles; Uric Acid; Virulence Factors, Bordetella | 1991 |
K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons.
Topics: Alkaloids; Animals; Brain; Carbazoles; Cell Differentiation; Cells, Cultured; Choline O-Acetyltransferase; Dopamine; Dose-Response Relationship, Drug; Indole Alkaloids; Mesencephalon; Nerve Growth Factors; Neurons; Protein Kinase C; Rats; Staurosporine | 1991 |
Role of protein kinase C in catecholamine secretion from digitonin-permeabilized bovine adrenal medullary cells.
Topics: Adrenal Medulla; Alkaloids; Animals; Carbazoles; Catecholamines; Cattle; Cell Membrane Permeability; Cells, Cultured; Digitonin; Indole Alkaloids; Kinetics; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase inhibitors and blood pressure control in spontaneously hypertensive rats.
Topics: Alkaloids; Animals; Blood Pressure; Carbazoles; Dose-Response Relationship, Drug; Heart Rate; Indole Alkaloids; Isoquinolines; Male; Myosin-Light-Chain Kinase; Nitrendipine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Staurosporine; Sulfonamides; Vasodilation | 1991 |
Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.
Topics: Alkaloids; Animals; Carbazoles; Cell Line; Diglycerides; Fibroblasts; Indole Alkaloids; Inositol; Kinetics; Lysophosphatidylcholines; Myristic Acid; Myristic Acids; Phospholipase D; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.
Topics: Alkaloids; Animals; Antigens; Arachidonic Acids; Calcimycin; Carbazoles; Cell Line; Cell Membrane; Cells, Cultured; Dexamethasone; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macrophages; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Serum Albumin, Bovine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Differential effects of protein kinase inhibitors on pre-established long-term potentiation in rat hippocampal neurons in vitro.
Topics: Alkaloids; Animals; Carbazoles; Evoked Potentials; Hippocampus; In Vitro Techniques; Indole Alkaloids; Male; Neurons; Protein Kinase C; Pyramidal Tracts; Rats; Rats, Inbred Strains; Staurosporine | 1991 |
Induced factor binding to the interferon-stimulated response element. Interferon-alpha and platelet-derived growth factor utilize distinct signaling pathways.
Topics: 2',5'-Oligoadenylate Synthetase; Alkaloids; Animals; Base Sequence; Carbazoles; Cross-Linking Reagents; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Indole Alkaloids; Interferon Type I; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Regulatory Sequences, Nucleic Acid; Signal Transduction; Staurosporine; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 1991 |
Mimicry and inhibition of nerve growth factor effects: interactions of staurosporine, forskolin, and K252a in PC12 cells and normal rat chromaffin cells in vitro.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Alkaloids; Animals; Animals, Newborn; Axons; Carbazoles; Cell Line; Colforsin; Dihydroxyphenylalanine; Dopamine; Indole Alkaloids; Kinetics; Nerve Growth Factors; Pheochromocytoma; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine | 1990 |
The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post-receptor mechanisms.
Topics: Alkaloids; Carbazoles; Dimethyl Sulfoxide; Humans; In Vitro Techniques; Indole Alkaloids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burst.
Topics: Alkaloids; Animals; Brain; Carbazoles; Cattle; Diglycerides; Fluorides; Humans; Indole Alkaloids; Kinetics; Myocardium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Rats; Staurosporine; Superoxides; Zymosan | 1990 |
Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line).
Topics: 6-Ketoprostaglandin F1 alpha; Alkaloids; Animals; Calcimycin; Carbazoles; Cell Line; Drug Synergism; Epoprostenol; Indole Alkaloids; Liver; Platelet Activating Factor; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors.
Topics: Alkaloids; Blood Platelets; Carbazoles; Diglycerides; Drug Synergism; Enzyme Activation; Feedback; Glycerides; Humans; Indole Alkaloids; Neomycin; Phosphatidic Acids; Phosphatidylcholines; Phosphorylation; Propranolol; Protein Kinase C; Second Messenger Systems; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Effect of concanavalin A on serotonin transport into blood platelets: possible involvement of protein kinase C.
Topics: Alkaloids; Animals; Biological Transport, Active; Blood Platelets; Blood Proteins; Calcium; Calcium Radioisotopes; Carbazoles; Concanavalin A; In Vitro Techniques; Indole Alkaloids; Indoles; Lanthanum; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Rabbits; Serotonin; Staurosporine | 1990 |
K252a is a potent and selective inhibitor of phosphorylase kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carbazoles; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Kinetics; Muscles; Phosphorylase Kinase; Piperazines; Protein Kinase Inhibitors; Rabbits; Staurosporine; Structure-Activity Relationship | 1990 |
Characterization of specific binding sites for [3H]-staurosporine on various protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Carbazoles; Indole Alkaloids; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Sulfonamides | 1990 |
Effect of staurosporine on histamine release from rat serosal mast cells.
Topics: Alkaloids; Animals; Calcimycin; Carbazoles; Histamine Release; Indole Alkaloids; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Protein Kinase C; Rats; Rats, Inbred Strains; Serous Membrane; Staurosporine | 1989 |
Differentiation of second messenger systems in mast cell activation.
Topics: Alkaloids; Animals; Antibodies, Anti-Idiotypic; Bone Marrow; Bone Marrow Cells; Calcimycin; Carbazoles; Cell Division; Histamine Release; Immunoglobulin E; Indole Alkaloids; Male; Mast Cells; Protein Kinase C; Rats; Second Messenger Systems; SRS-A; Staurosporine | 1989 |
Potent selective inhibitors of protein kinase C.
Topics: Alkaloids; Animals; Antigens, Differentiation, T-Lymphocyte; Blood Platelets; Brain; Carbazoles; CD3 Complex; Dose-Response Relationship, Drug; Down-Regulation; Imides; Indole Alkaloids; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Antigen, T-Cell; Staurosporine; Structure-Activity Relationship | 1989 |
Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.
Topics: Alkaloids; Animals; Carbazoles; Cell Compartmentation; Cell Membrane; Cytosol; Down-Regulation; Enzyme Activation; Glucose; In Vitro Techniques; Indole Alkaloids; Insulin; Insulin Secretion; Islets of Langerhans; Male; Protein Kinase C; Protein Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Glucose; Hippocampus; Homeostasis; Indole Alkaloids; Neurons; Phosphorylation; Phosphotyrosine; Rats; Septum Pellucidum; Staurosporine; Tyrosine | 1994 |
Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Blotting, Western; Carbazoles; Cell Line; Cells, Cultured; Ciliary Neurotrophic Factor; Cytokines; Growth Inhibitors; Indole Alkaloids; Interleukin-6; Isoquinolines; Leukemia Inhibitory Factor; Lymphokines; Nerve Growth Factors; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oncostatin M; Peptides; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; ras Proteins; Rats; RNA; RNA, Messenger; Staurosporine; Superior Cervical Ganglion; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
The timing of protein kinase activation events in the cascade that regulates mitotic progression in Tradescantia stamen hair cells.
Topics: Alkaloids; Anaphase; Carbazoles; Cell Division; Cells, Cultured; Enzyme Activation; Indole Alkaloids; Mitosis; Naphthalenes; Oligopeptides; Plant Cells; Plants; Polycyclic Compounds; Protein Kinase C; Staurosporine | 1995 |
Biphasic effect of staurosporine on thymocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Apoptosis; Bucladesine; Calcimycin; Carbazoles; Carcinogens; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Indole Alkaloids; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase Inhibitors; Radiation-Sensitizing Agents; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1995 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
K252a, a potent inhibitor of protein kinases, promotes the transition of Dictyostelium cells from growth to differentiation.
Topics: Alkaloids; Animals; Carbazoles; Cell Cycle; Cell Differentiation; Cell Division; Dictyostelium; Indole Alkaloids; Pinocytosis; Protein Kinase Inhibitors; Signal Transduction; Staurosporine | 1994 |
Membranes of human neuroblastoma SH-SY5Y cells contain specific binding sites for [3H]K-252A.
Topics: Alkaloids; Binding Sites; Carbazoles; Cell Line; Humans; Indole Alkaloids; Indoles; Kinetics; Maleimides; Neuroblastoma; Protein Kinase C; Staurosporine; Substrate Specificity; Tritium; Tumor Cells, Cultured | 1995 |
Production of the staurosporine aglycon K-252c with a blocked mutant of the staurosporine producer strain Streptomyces longisporoflavus and by biotransformation of staurosporine with Streptomyces mediocidicus ATCC 13279.
Topics: Alkaloids; Carbazoles; Indole Alkaloids; Mutation; Protein Kinase C; Staurosporine; Streptomyces | 1995 |
Differential sensitivity to inhibitors discriminates between two types of kinases responsible for in vivo phosphorylation of different sites in the carboxy-terminal tail of chicken neurofilament-M.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Chick Embryo; Ganglia, Spinal; Indole Alkaloids; Isoquinolines; Lithium Chloride; Molecular Sequence Data; Neurofilament Proteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sphingosine; Staurosporine; Trifluoperazine | 1994 |
Staurosporine and K-252 compounds protect hippocampal neurons against amyloid beta-peptide toxicity and oxidative injury.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Carbazoles; Hippocampus; Indole Alkaloids; Neurons; Oxidation-Reduction; Protein Kinase C; Rats; Staurosporine | 1994 |
K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Cell Division; Cell Line; CHO Cells; Cricetinae; Drug Synergism; Indole Alkaloids; Indoles; Myosin-Light-Chain Kinase; Paclitaxel; Pyrroles; Staurosporine | 1994 |
Staurosporine and its derivatives enhance f-Met-Leu-Phe-induced superoxide production via phospholipase D activation in human polymorphonuclear leukocytes.
Topics: Alkaloids; Amino Acid Sequence; Carbazoles; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Humans; Indole Alkaloids; Male; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Pharmacological evidence for regulation of Na(+)-Ca++ exchange by Ca++/calmodulin-dependent protein kinase in isolated bovine adrenal medullary cells.
Topics: Adrenal Medulla; Alkaloids; Animals; Calcium; Calcium Radioisotopes; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Carrier Proteins; Catecholamines; Cattle; Cells, Cultured; Enzyme Activation; Indole Alkaloids; Sodium; Sodium-Calcium Exchanger; Staurosporine | 1994 |
Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors.
Topics: Alkaloids; Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Calcimycin; Candida albicans; Carbazoles; Escherichia coli; Indole Alkaloids; Indoles; Microbial Sensitivity Tests; Mitosporic Fungi; Phosphorylation; Protein Kinase C; Staurosporine; Streptomyces; Streptomyces griseus | 1994 |
Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Drug Interactions; Drug Resistance; Gene Expression; Humans; Indole Alkaloids; Isoquinolines; KB Cells; Membrane Glycoproteins; Neoplasm Proteins; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Verapamil | 1993 |
Facilitatory effect of phorbol ester on 2-deoxyglucose uptake in rat hippocampal slices.
Topics: Alkaloids; Animals; Carbachol; Carbazoles; Deoxyglucose; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Indole Alkaloids; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Rats; Rats, Wistar; Staurosporine | 1993 |
Phospholipase D activation in PDGF-stimulated vascular smooth muscle cells.
Topics: Alkaloids; Animals; Becaplermin; Carbazoles; Cell Line; Enzyme Activation; Indole Alkaloids; Kinetics; Muscle, Smooth, Vascular; Phospholipase D; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Staurosporine | 1993 |
Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC.
Topics: Alkaloids; Animals; Carbazoles; Cattle; Indole Alkaloids; Isoenzymes; Protein Kinase C; Staurosporine; Substrate Specificity | 1993 |
Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Blood Platelets; Carbazoles; Carrier Proteins; Humans; Hydrogen; Indole Alkaloids; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine; Thrombin | 1993 |
Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzoquinones; Carbazoles; Cell Differentiation; Fungal Proteins; Indole Alkaloids; Isoquinolines; Lactams, Macrocyclic; Manganese; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Streptomyces griseus | 1993 |
Protein kinase C inhibitors potentiate angiotensin II-induced phosphoinositide hydrolysis and intracellular Ca2+ mobilization in renal mesangial cells.
Topics: Alkaloids; Angiotensin II; Animals; Calcium; Carbazoles; Cells, Cultured; Glomerular Mesangium; Hydrolysis; Indole Alkaloids; Inositol 1,4,5-Trisphosphate; Isoenzymes; Protein Kinase C; Rats; Spectrometry, Fluorescence; Staurosporine | 1993 |
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1993 |
K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures.
Topics: Alkaloids; Animals; Carbazoles; Cell Differentiation; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Ciliary Neurotrophic Factor; Indole Alkaloids; Mitogens; Motor Neurons; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Parasympathetic Nervous System; Protein Kinase Inhibitors; Rats; Spinal Cord; Staurosporine; Time Factors | 1993 |
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity | 1996 |
Stimulation of nuclear import by simian virus 40-transformed cell extracts is dependent on protein kinase activity.
Topics: 3T3 Cells; Alkaloids; Animals; Carbazoles; Cattle; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Enzyme Inhibitors; Gold Colloid; Indole Alkaloids; Kinetics; Mice; Mice, Inbred BALB C; Nuclear Proteins; Nucleoplasmins; Phosphoproteins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Serum Albumin, Bovine; Simian virus 40; Staurosporine | 1995 |
Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors.
Topics: Alkaloids; Animals; Bryostatins; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Lactones; Macrolides; Models, Biological; Neoplasm Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thioguanine | 1995 |
Inhibition of chemomigration of a human prostatic carcinoma cell (TSU-pr1) line by inhibition of epidermal growth factor receptor function.
Topics: Alkaloids; Antibodies, Monoclonal; Carbazoles; Carcinogens; Carcinoma; Cell Movement; Dimethyl Sulfoxide; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; Indole Alkaloids; Male; Neoplasm Metastasis; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1996 |
Na(+)-K(+)-2Cl- cotransport, Na+/H+ exchange, and cell volume in ferret erythrocytes.
Topics: Adenosine Triphosphate; Animals; Bumetanide; Carbazoles; Carrier Proteins; Chlorides; Enzyme Inhibitors; Erythrocyte Membrane; Erythrocytes; Ferrets; In Vitro Techniques; Indole Alkaloids; Kinetics; Male; Membrane Proteins; Potassium; Protein Kinase Inhibitors; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Staurosporine | 1996 |
Evidence for G-protein-dependent and G-protein-independent activation of phospholipase D in lymphocytes.
Topics: Animals; Carbazoles; Catalysis; Cattle; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Indole Alkaloids; Lymphocytes; Phosphatidylethanolamines; Phospholipase D; Prostaglandins; Protein Kinase C; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
The staurosporine producing strain Streptomyces longisporoflavus produces metabolites related to K-252a. Proposal for biosynthetic intermediates of K-252a.
Topics: Animals; Carbazoles; Enzyme Inhibitors; Indole Alkaloids; Magnetic Resonance Spectroscopy; Molecular Structure; Protein Kinase C; Staurosporine; Streptomyces; Swine | 1996 |
Involvement of protein kinase C in nerve growth factor- and K-252a-stimulated calcium uptake into PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Agonists; Carbazoles; Carcinogens; Enzyme Inhibitors; Indole Alkaloids; Indoles; Isoenzymes; Naphthalenes; Nerve Growth Factors; PC12 Cells; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2.
Topics: Alternative Splicing; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Line; Cerebellum; Enzyme Inhibitors; Humans; Indole Alkaloids; L Cells; Mice; Mutagenesis, Site-Directed; Nerve Growth Factors; Polymerase Chain Reaction; Protein Structure, Secondary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Rats; Receptor, Ciliary Neurotrophic Factor; Receptors, Nerve Growth Factor; Recombinant Proteins; Sequence Deletion; Signal Transduction; Staurosporine; Transfection | 1997 |
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Carbazoles; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Heat-Shock Proteins; Humans; Indole Alkaloids; Intracellular Signaling Peptides and Proteins; Mice; Phosphorylation; Protein Serine-Threonine Kinases; Staurosporine | 1997 |
Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase.
Topics: Adenoviruses, Human; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Humans; Indole Alkaloids; Indoles; Isoflavones; Isoquinolines; Lactoferrin; Low Density Lipoprotein Receptor-Related Protein-1; Maleimides; Melanoma; Naphthalenes; Phenols; Protein Kinase C; Receptors, Immunologic; Signal Transduction; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1997 |
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Goldfish; Indole Alkaloids; Nerve Crush; Neurites; Okadaic Acid; Optic Nerve; Protein Kinase C; Protein Kinase Inhibitors; Retina; Sphingosine; Staurosporine | 1997 |
Multidrug resistance phenotype conferred by overexpressing bfr2+/pad1+/sks1+ or pap1+ genes and mediated by bfr1+ gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe.
Topics: Anti-Bacterial Agents; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brefeldin A; Carbazoles; Cyclopentanes; Cytochalasin B; Dactinomycin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Fungal Proteins; Gene Expression Regulation, Fungal; Indole Alkaloids; Macrolides; Mycotoxins; Pancreatitis-Associated Proteins; Phenotype; Protein Kinase C; Protein Synthesis Inhibitors; Repressor Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Sequence Analysis, DNA; Staurosporine | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
Protein kinase C-independent selective induction of nitric oxide synthase activity in rat alveolar macrophages by staurosporine.
Topics: Animals; Carbazoles; Cell Line; Enzyme Induction; Enzyme Inhibitors; Indole Alkaloids; Isoenzymes; Lipopolysaccharides; Macrophages, Alveolar; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Novel effects on the Gonyaulax circadian system produced by the protein kinase inhibitor staurosporine.
Topics: Animals; Carbazoles; Circadian Rhythm; Dinoflagellida; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indole Alkaloids; Light; Light Signal Transduction; Luminescent Measurements; Molecular Weight; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proteins; Staurosporine; Time Factors | 1999 |
Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors.
Topics: Anthraquinones; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Genistein; Humans; Indole Alkaloids; Indoles; Lactams, Macrocyclic; Maleimides; Microscopy, Phase-Contrast; Nuclear Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Ultraviolet Rays | 1999 |
The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.
Topics: Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chick Embryo; Chickens; CHO Cells; Cricetinae; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Glucosides; Indole Alkaloids; Nerve Growth Factors; Neurites; Neurons; Neurotrophin 3; Protein Kinase C; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Staurosporine | 1999 |
Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages.
Topics: Animals; Carbazoles; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Indole Alkaloids; Indoles; Interleukin-6; Isoquinolines; Macrophages, Peritoneal; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Time Factors | 1999 |
Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets.
Topics: Amidines; Animals; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Drug Design; Enzyme Inhibitors; Flavonoids; Imidazoles; Indole Alkaloids; Isoquinolines; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Pyridines; Staurosporine; Sulfonamides | 1999 |
Syringolin-mediated activation of the Pir7b esterase gene in rice cells is suppressed by phosphatase inhibitors.
Topics: Carbazoles; Cycloheximide; Enzyme Inhibitors; Esterases; Indole Alkaloids; Okadaic Acid; Oryza; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Protein Synthesis Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Transcription, Genetic | 2000 |
Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway.
Topics: Amino Acid Sequence; Animals; Carbazoles; Cell Cycle Proteins; Cell Line; Gene Expression Regulation; Golgi Apparatus; Humans; Indole Alkaloids; Interferons; Membrane Transport Proteins; Mice; Molecular Sequence Data; NF-kappa B; Phosphoproteins; Phosphorylation; Sequence Homology, Amino Acid; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factor TFIIIA; Tumor Necrosis Factor-alpha | 2000 |
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
Topics: Amino Acid Sequence; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genistein; GTP-Binding Proteins; Indole Alkaloids; Indoles; Lysine; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Receptor, trkB; RNA, Messenger; Staurosporine; Tyrosine; Xenopus | 2000 |
Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.
Topics: Acetylcholine; Allosteric Regulation; Allosteric Site; Animals; Carbazoles; CHO Cells; Cricetinae; Enzyme Inhibitors; Indole Alkaloids; Indoles; N-Methylscopolamine; Pyrroles; Radioligand Assay; Receptors, Muscarinic; Staurosporine | 2000 |
Establishment of a tetraploid Meth-A cell line through polyploidization by demecolcine but not by staurosporine, K-252A and paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carbazoles; Cell Count; Cell Cycle; Cell Division; Demecolcine; DNA; Enzyme Inhibitors; Flow Cytometry; Indole Alkaloids; Karyotyping; Mice; Paclitaxel; Ploidies; Sarcoma; Staurosporine; Tumor Cells, Cultured | 2001 |
Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indole Alkaloids; Indoles; Isoproterenol; Isoquinolines; Maleimides; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Parotid Gland; Peptides, Cyclic; Phenols; Phosphorus Radioisotopes; Phosphorylation; Rats; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Staurosporine; Sulfonamides; Sympathomimetics; Vanadates | 2002 |
Characterization of early, chitin-induced gene expression in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Carbazoles; Chitin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Plant; Indole Alkaloids; Lectins; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Okadaic Acid; Oligosaccharides; Oxazoles; Phosphorylation; Plant Proteins; RNA, Messenger; Signal Transduction; Staurosporine; Transcriptional Activation; Zinc Fingers | 2002 |
A fluorescence polarization assay for native protein substrates of kinases.
Topics: Amino Acid Sequence; Carbazoles; Cell Cycle Proteins; Enzyme Inhibitors; Fluorescence Polarization; Fluorescent Dyes; Humans; Indole Alkaloids; Membrane Proteins; Nuclear Proteins; Peptides; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Time Factors | 2003 |
Staurosporine-inhibitable protein kinase activity associated with secretory granule membranes isolated from rat submandibular gland cells.
Topics: Animals; Calcium; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indole Alkaloids; Membrane Proteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Secretory Vesicles; Staurosporine; Submandibular Gland | 2003 |
Protein phosphorylation is a prerequisite for intracellular Ca2+ release and ion channel control by nitric oxide and abscisic acid in guard cells.
Topics: Abscisic Acid; Calcium; Calcium Signaling; Carbazoles; Cell Membrane; Genistein; Indole Alkaloids; Ion Channels; Membrane Potentials; Nitric Oxide; Phosphorylation; Plant Proteins; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Staurosporine; Vicia faba | 2005 |
Synthesis of N-protected staurosporinones.
Topics: Carbazoles; Catalysis; Indole Alkaloids; Indoles; Ketones; Staurosporine | 2007 |
Polyploidization of 2nH1 (ES) cells by K-252a and staurosporine.
Topics: Alkaline Phosphatase; Animals; Carbazoles; Cell Cycle; Cells, Cultured; Culture Media; DNA; Embryonal Carcinoma Stem Cells; Embryonic Stem Cells; Enzyme Inhibitors; Indole Alkaloids; Leukemia Inhibitory Factor; Male; Mice; Mice, Inbred C3H; Polyploidy; Staurosporine | 2007 |
Staurosporine-based binding assay for testing the affinity of compounds to protein kinases.
Topics: Binding Sites; Binding, Competitive; Carbazoles; Indole Alkaloids; Intracellular Signaling Peptides and Proteins; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Spectrometry, Fluorescence; Staurosporine | 2008 |
Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs.
Topics: Actinomycetales; Base Pairing; Carbazoles; Cloning, Molecular; Escherichia coli; Gene Library; Genome, Bacterial; Indole Alkaloids; Indoles; Molecular Sequence Data; Multigene Family; Sequence Analysis, DNA; Staurosporine | 2009 |
Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.
Topics: Amino Acid Sequence; Binding Sites; Carbazoles; Cloning, Molecular; Flavin-Adenine Dinucleotide; Indole Alkaloids; Indoles; Molecular Sequence Data; Molecular Structure; Oxidation-Reduction; Oxygenases; Pyrroles; Staurosporine; Streptomyces; Substrate Specificity | 2011 |
Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein-Barr virus.
Topics: Animals; Antiviral Agents; Butadienes; Carbazoles; Cell Line, Tumor; Cell Survival; Genome, Viral; Herpesvirus 4, Human; Humans; Indole Alkaloids; MAP Kinase Signaling System; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; NF-kappa B; Nitriles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Sf9 Cells; Staurosporine; Viral Proteins; Virus Replication | 2012 |
Staurosporine analogs promote distinct patterns of process outgrowth and polyploidy in small cell lung carcinoma cells.
Topics: Carbazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Furans; Humans; Indole Alkaloids; Polyploidy; Signal Transduction; Small Cell Lung Carcinoma; Staurosporine | 2015 |
Important role of a LAL regulator StaR in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576.
Topics: Bacterial Proteins; Binding Sites; Carbazoles; Cloning, Molecular; DNA Mutational Analysis; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Regulator; Indole Alkaloids; Multigene Family; Mutation; Staurosporine; Streptomyces coelicolor | 2019 |
2,3,5,4'-tetrahydoxystilbene-2-O-β-D-glucoside eliminates staurosporine-induced cytotoxicity by restoring BDNF-TrkB/Akt signaling axis.
Topics: Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Survival; Cells, Cultured; Chromones; Fallopia multiflora; Glucosides; Hippocampus; Indole Alkaloids; Morpholines; Neurons; Neuroprotective Agents; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Receptor, trkB; Signal Transduction; Staurosporine; Stilbenes | 2020 |