staurosporine has been researched along with sphingosine in 132 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (4.55) | 18.7374 |
| 1990's | 97 (73.48) | 18.2507 |
| 2000's | 19 (14.39) | 29.6817 |
| 2010's | 10 (7.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burch, RM; Carter, JP; Connor, JR; Mathew, RM; Patch, RJ; Shearer, BG; Sullivan, JP; Waid, P | 1 |
| Rodríguez Del Castillo, A; Trifaró, JM; Vitale, ML | 1 |
| Noble, EP; Ritchie, T; Rosenberg, A | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Bennett, MV; Durand, GM; Gregor, P; Uhl, GR; Zheng, X; Zukin, RS | 1 |
| Pradines-Figueres, A; Raetz, CR | 1 |
| Deli, E; Kiss, Z | 1 |
| Fujii, T; Hashizume, T; Sato, T | 1 |
| Felipo, V; Grisolía, S; Llopis, J; Miñana, MD; Romá, J; Romero, FJ | 1 |
| Evans, CH; Georgescu, HI; Hulkower, KI | 1 |
| MacGlashan, DW; Warner, JA | 1 |
| Kojima, I; Shibata, H | 1 |
| Barrett, KE; Dharmsathaphorn, K; Dinh, S; Kachintorn, U; Vajanaphanich, M; Vongkovit, P | 1 |
| Bement, WM; Capco, DG | 1 |
| Charbonneau, M; Grandin, N | 1 |
| Apgar, JR | 1 |
| Elliott, ME; Goodfriend, TL; Jones, HM; Tomasko, S | 1 |
| Sauro, MD; Zorn, NE | 2 |
| Russell, DH; Zorn, NE | 1 |
| Farley, J; Schuman, E | 1 |
| Campenot, RB; Draker, DD; Walji, AH | 1 |
| Bell, SC; Capetola, RJ; Goodman, MG; Gupta, S; Rosenthale, ME; Weigle, WO | 1 |
| Martin, DB; Pek, SB; Thomas, TP | 1 |
| Brindley, DN; Gomez-Muñoz, A; Hales, P | 1 |
| Barnett, NL; Broyden, NJ; Morris, NJ; Osborne, NN | 1 |
| Crane, DL; Elliott, MS | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Honma, Y; Hozumi, M; Kasukabe, T; Okabe-Kado, J; Umezawa, K | 1 |
| Dufau, ML; Fabbri, A; Tinajero, JC; Ulisse, S | 1 |
| Brieland, JK; Fantone, JC; McNish, RW; Peters-Golden, M | 1 |
| Goodman, HM; Gorin, E; Honeyman, TW; Tai, LR | 1 |
| Adu, J; Burgoyne, RD; Cambray-Deakin, MA | 1 |
| Russell, DH; Weill, CL; Zorn, NE | 1 |
| Boscá, L; Díaz-Guerra, MJ; Junco, M | 1 |
| Ikebuchi, H; Saito, Y; Suzuki, K; Suzuki, S; Terao, T | 1 |
| Cobbold, PH; Cuthbertson, KS; Dixon, CJ; Sanchez-Bueno, A; Woods, NM | 1 |
| August, J; Bishop, WR; Pai, JK; Petrin, JM | 1 |
| Baines, AD; Ho, P | 1 |
| Homonnai, ZT; Kalina, M; Naor, Z; Paz, GF; Rotem, R | 1 |
| Easom, RA; McDaniel, ML; Turk, J; Wolf, BA | 1 |
| Bedoy, CA; Mobley, PL | 1 |
| Insel, PA; Slivka, SR; Weiss, BA | 1 |
| Jacobson, D; O'Flaherty, JT | 1 |
| Arese, P; Bussolino, F; Fischer, E; Kazatchkine, MD; Turrini, F | 1 |
| Capeau, J; Caron, M; Cherqui, G; Picard, J; Wicek, D | 1 |
| Gelfand, EW; Hill, M; May, C; Mills, GB | 1 |
| Artini, M; Avantaggiati, ML; Balsano, C; Chirillo, P; Costanzo, A; Levrero, M; Natoli, G | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| He, H; Herington, AC; Roupas, P | 1 |
| Brooks, BJ; Elliott, MS; Eriotou, P; Hart, KL; Kelly, DF; Morris, RC; Sagar, S | 1 |
| Terrian, DM; Ways, DK | 1 |
| Basu, U; Bennett, GS; Hollander, BA; Quintana, R; Rodriguez, R | 1 |
| Hunchuk, N; Li, XB; Wong, K | 1 |
| Baumgold, J; Curran, P; Fishman, PH; Zhou, XM | 1 |
| Anderson, WH; Kiss, Z | 2 |
| Aviram, M; Oiknine, J | 1 |
| Cordier, J; Glowinski, J; Murphy, NP; Prémont, J | 1 |
| Andersen, CB; Hansen, AB | 1 |
| Andersen, CB; Bouchelouche, PN; Giese, BN; Hansen, AB | 1 |
| Kiss, Z | 1 |
| Buschmann, J; Heinrich, PC; Horn, F; Lottspeich, F; Lütticken, C; Müller-Esterl, W; Roeb, E; Schindler, C; Wegenka, UM; Yuan, J | 1 |
| Tschaikowsky, K | 1 |
| Boniece, IR; Maiese, K; Skurat, K; Wagner, JA | 1 |
| Allen, K; Bell, MA; Carwell, N; Davis, DL; Ganesan, U; Kuo, WN; McCall, LK; Siddeeq, S; Walbey, DL | 1 |
| Hakomori, S; Igarashi, Y; Mazurek, N; Megidish, T | 1 |
| Cunningham, GR; House, FS; Stewart, SJ | 1 |
| Akkerman, JW; Burgers, JA | 1 |
| Rossignol, B; Sergheraert, C; Zoukhri, D | 1 |
| Davis, BB; Thomas, DJ; Zenser, TV | 1 |
| Ishikawa, Y; Ogawa, A; Sasakawa, S | 1 |
| Albino, AP; Jiang, J; Kelsen, D; Schwartz, GK | 1 |
| Bayat-Sarmadi, M; Houdebine, LM | 1 |
| Christ, D; Minardi, AJ; Saz, HJ | 1 |
| Campbell, XZ; Neet, KE | 1 |
| Dawson, G; Wiesner, DA | 1 |
| Hakomori, S; Igarashi, Y; Sakakura, C; Shirahama, T; Sweeney, EA | 1 |
| Egashira, K; Fukumoto, Y; Ito, A; Kadokami, T; Shimokawa, H; Takayanagi, T; Takeshita, A | 1 |
| Hashizume, T; Nakao, M; Sato, T | 1 |
| Ducibella, T; LeFevre, L | 1 |
| Igarashi, Y; Kume, S; Ozaki, Y; Ruan, F; Satoh, K; Yatomi, Y | 1 |
| Bredesen, DE; Foster, LM; Kayalar, C; Keane, RW; Nonner, D; Ord, T; Reed, JC; Srinivasan, A; Testa, MP; Wang, HG | 1 |
| Igarashi, Y; Nishiyama, K; Ohi, Y; Ozawa, M; Sakakura, C; Shirahama, T; Sweeney, EA; Takemoto, M | 1 |
| Agranoff, BW; Heacock, AM | 1 |
| Grinstein, S; Törnquist, K; Woodside, M | 1 |
| Baker, A; Briehl, MM; Payne, CM; Powis, G | 1 |
| Cheng, AJ; Ku, WC; Wang, TC | 1 |
| Searl, TJ; Silinsky, EM | 1 |
| Adams, LM; Darges, JW; Robinson, SP | 1 |
| Benton, HP; Koolpe, M; Rodrigo, JJ | 1 |
| Himmelreich, NH; Pozdnyakova, NG; Storchak, LG | 1 |
| Patel, M | 1 |
| Chin, TY; Chueh, SH | 2 |
| Grosman, N | 1 |
| Clift, RE; Reiners, JJ | 1 |
| Hrelia, S; Orlati, S; Porcelli, AM; Rugolo, M | 1 |
| Boustany, RM; Guo, WX; Nikbakht, K; Puranam, KL; Qian, WH | 1 |
| Malaquias, AT; Oliveira, MM | 1 |
| Askew, DJ; Brunner, T; Green, DR; Kuscuoglu, U; Miesfeld, RL | 1 |
| Grant, S; Jarvis, WD | 1 |
| Kobayashi, S; Kumagai, M; Makioka, A; Ohtomo, H; Takeuchi, T | 1 |
| Böhmer, FD; Bosch, TC; Cardenas, M; Cerbon, J; Fabila, YV; Fujisawa, T; Salgado, LM; Wetzker, R; Yum, S | 1 |
| Bhakdi, S; Gulbins, E; Tappe, D; Walev, I | 1 |
| Cho, S; Dawson, G; Dawson, PE | 1 |
| da Rocha, AB; Mans, DR; Regner, A; Schwartsmann, G | 1 |
| Choi, DW; Goldberg, MP; Hyrc, K; Sheline, C; Wang, XQ; Xiao, AY; Yang, A; Yu, SP | 1 |
| Dawson, G; Dawson, SA; Moskal, JR | 1 |
| Djanani, AM; Feistritzer, C; Kaneider, NC; Lindner, J; Mosheimer, BA; Sturn, DH; Wiedermann, CJ | 1 |
| Huwiler, A; Pfeilschifter, J; Ren, S; Xin, C | 1 |
| Hisano, N; Igarashi, Y; Nakahara, K; Ozaki, Y; Yamamura, S; Yatomi, Y | 1 |
| Dawson, G; Goswami, R; Kilkus, J; Phillips, G; Singh, D | 1 |
| Carpenter, DO; Hussain, RJ | 1 |
| Brüne, B; Geisslinger, G; Johann, AM; Schmidt, H; von Knethen, A; Weigert, A | 1 |
| Altevogt, P; Gast, D; Gutwein, P; Issa, Y; Sanderson, MP; Stoeck, A | 1 |
| Caruso-Neves, C; Einicker-Lamas, M; Masuda, CA; Nascimento, MT; Oliveira, MM | 1 |
| Brüne, B; Geisslinger, G; Johann, AM; Schmidt, H; Tzieply, N; von Knethen, A; Weigert, A | 1 |
| Hanck, T; Li, R; Reiser, G; Rohatgi, T | 1 |
| Furuchi, T; Homma, H; Katane, M; Sekine, M; Suzuki, T | 1 |
| Li, R; Reiser, G | 1 |
| Fox, TE; Gowda, R; Hengst, J; Madhunapantula, SV; Robertson, GP; Yun, JK | 1 |
| Li, R; Reiser, G; Zhu, Z | 1 |
| Chieng, YC; Hoon, LS; Hsum, YW; Mooi, LY; Soo, KK; Yew, WT | 1 |
| Chung, DI; Hong, Y; Kong, HH; Moon, EK | 1 |
| Faden, AI; Hanscom, M; Piao, CS; Sabirzhanov, B; Stoica, BA | 1 |
| Ford, AL; Gonzales, E; Holtzman, DM; Lee, JM; Lee, KY; West, T; Xiao, Q; Xu, J; Yan, P | 1 |
| Doyle, A; Leanza, L; O'Reilly, P; Szabo, I; Szegezdi, E; Venturini, E; Zoratti, M | 1 |
| Iba, A; Morita, M; Nagahara, Y; Nakata, T; Shinomiya, T | 1 |
| Li, R; Reiser, G; Stricker, R; Zhu, Z | 1 |
2 review(s) available for staurosporine and sphingosine
| Article | Year |
|---|---|
Protein kinase C targeting in antineoplastic treatment strategies.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cell Survival; Cytoprotection; Enzyme Inhibitors; Humans; Lactones; Macrolides; Mitogen-Activated Protein Kinase Kinases; Naphthalenes; Protein Kinase C; Sphingosine; Staurosporine | 1999 |
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
Topics: Adolescent; Adult; Antineoplastic Agents; Apoptosis; Bryostatins; Cell Division; Child; Child, Preschool; Enzyme Activation; Enzyme Inhibitors; Glioma; Humans; Infant; Lactones; Macrolides; Mutation; Naphthalenes; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Protein Kinase C; Sphingosine; Staurosporine | 2002 |
130 other study(ies) available for staurosporine and sphingosine
| Article | Year |
|---|---|
Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors.
Topics: Enzyme Activation; Enzyme Inhibitors; Phorbol Esters; Piperidines; Protein Kinase C | 1991 |
Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation.
Topics: Actins; Adrenal Medulla; Alkaloids; Animals; Calcium; Cattle; Enzyme Activation; Exocytosis; Kinetics; Macromolecular Substances; Microscopy, Fluorescence; Naphthalenes; Nicotine; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Receptors, Nicotinic; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine.
Topics: Alkaloids; Animals; Animals, Newborn; Astrocytes; Brain; Calcium; Cells, Cultured; Egtazic Acid; Hydrolysis; Inositol Phosphates; Kinetics; Norepinephrine; Phosphatidylinositols; Protein Kinase C; Psychosine; Rats; Sphingosine; Staurosporine | 1992 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Colforsin; Diterpenes; Enzyme Activation; Female; Genetic Variation; Kinetics; Ligands; Molecular Sequence Data; N-Methylaspartate; Oligodeoxyribonucleotides; Oocytes; Polyamines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing; Sphingosine; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Xenopus laevis | 1992 |
Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cysteine; Dose-Response Relationship, Drug; Endotoxins; Humans; Isoquinolines; Kinetics; Lipopolysaccharides; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Staurosporine; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Bryostatins; Down-Regulation; Drug Interactions; Ethers, Cyclic; Hydrolysis; Lactones; Macrolides; Mice; Okadaic Acid; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases | 1992 |
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Enzyme Activation; Glutathione; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1992 |
Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.
Topics: Alkaloids; Animals; Cartilage, Articular; Cells, Cultured; Dinoprostone; Enzyme Activation; Fibroblast Growth Factor 2; Gelatinases; Interleukin-1; Isoenzymes; Kinetics; Pepsin A; Phosphoproteins; Phosphorylation; Protein Kinase C; Rabbits; Recombinant Proteins; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Basophils; Calcium; Cell Degranulation; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptor Aggregation; Signal Transduction; Sphingosine; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa | 1991 |
Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Line; Chlorides; Colon; Humans; Intestinal Mucosa; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase Inhibitors; Rubidium; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Analysis of inducible contractile rings suggests a role for protein kinase C in embryonic cytokinesis and wound healing.
Topics: Alkaloids; Animals; Calcium; Cell Division; Cell-Free System; Egtazic Acid; Female; Hydrogen-Ion Concentration; Neomycin; Oocytes; Phorbol Esters; Protein Kinase C; Second Messenger Systems; Sphingosine; Staurosporine; Wound Healing; Xenopus laevis | 1991 |
Intracellular pH and intracellular free calcium responses to protein kinase C activators and inhibitors in Xenopus eggs.
Topics: Alkaloids; Animals; Calcium; Female; Hydrogen-Ion Concentration; Intracellular Fluid; Oocytes; Protein Kinase C; Sphingosine; Staurosporine; Xenopus laevis | 1991 |
Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C.
Topics: Actins; Alkaloids; Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Calcium; Carbazoles; Cell Line; Diglycerides; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macromolecular Substances; Protein Kinase C; Rats; Receptors, Fc; Receptors, IgE; Serotonin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Sphingosine inhibits angiotensin-stimulated aldosterone synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Angiotensin II; Animals; Bucladesine; Cattle; Cells, Cultured; Isoquinolines; Ouabain; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Zona Glomerulosa | 1991 |
Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Cyclosporins; DNA; Enzyme Activation; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Platelet-Derived Growth Factor; Prolactin; Protein Kinase C; Receptors, Prolactin; Sphingosine; Staurosporine; Thymidine; Tritium | 1991 |
Vasoactive intestinal peptide (VIP) activation of nuclear protein kinase C in purified nuclei of rat splenocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Benzodiazepinones; Cell Nucleus; Enzyme Activation; Insulin-Like Growth Factor I; Isoquinolines; Male; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; Somatostatin; Sphingosine; Spleen; Staurosporine; Vasoactive Intestinal Peptide | 1990 |
Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Electric Stimulation; In Vitro Techniques; Isoquinolines; Microelectrodes; Nervous System Physiological Phenomena; Photoreceptor Cells; Piperazines; Protein Kinase C; Snails; Sphingosine; Staurosporine | 1991 |
Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures.
Topics: Alkaloids; Animals; Axons; Cells, Cultured; Immunoglobulin G; Microscopy, Phase-Contrast; Nerve Degeneration; Nerve Growth Factors; Neurons; Protein Kinase C; Rats; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibody Formation; Antigens, CD; Cell Division; Concanavalin A; Dose-Response Relationship, Drug; Female; Guanosine; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunophenotyping; In Vitro Techniques; Isoquinolines; Lymphocytes; Male; Middle Aged; Piperazines; Pokeweed Mitogens; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Staurosporine | 1991 |
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Unsaturated fatty acids activate glycogen phosphorylase in cultured rat hepatocytes.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Corticosterone; Enzyme Activation; Estradiol; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Kinetics; Liver; Male; Phosphorylase a; Phosphorylases; Progesterone; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Testosterone | 1991 |
Protein kinase C (alpha and beta) immunoreactivity in rabbit and rat retina: effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Aging; Alkaloids; Animals; Antibodies, Monoclonal; Cell Membrane; Cytosol; Fluorescent Antibody Technique; In Vitro Techniques; Isoenzymes; Isoquinolines; Kinetics; Phorbol Esters; Piperazines; Protein Kinase C; Quisqualic Acid; Rabbits; Rats; Retina; Sphingosine; Staurosporine | 1991 |
Protein kinase C modulation of queuine uptake in cultured human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cells, Cultured; Diglycerides; Enzyme Activation; Fibroblasts; Growth Substances; Guanine; Humans; In Vitro Techniques; Isoquinolines; Male; Phorbol Esters; Phosphatidylserines; Piperazines; Protein Kinase C; Sphingosine; Staurosporine | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells.
Topics: Alkaloids; Antibiotics, Antineoplastic; Azepines; Benzoquinones; Cell Differentiation; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Erythrocytes; Genes, abl; Genistein; Humans; Hydroquinones; In Vitro Techniques; Isoflavones; Lactams, Macrocyclic; Leukemia, Myeloid; Myosin-Light-Chain Kinase; Oligonucleotides, Antisense; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Quinones; Rifabutin; RNA, Messenger; Sphingosine; Staurosporine | 1990 |
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cells, Cultured; Chorionic Gonadotropin; Corticotropin-Releasing Hormone; Cyclic AMP; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Leydig Cells; Male; Protein Kinase C; Rats; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate | 1990 |
Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Dinoprostone; Eicosanoids; Enzyme Activation; Female; Macrophages; Peritoneal Cavity; Phorbol Esters; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Superoxides; Zymosan | 1990 |
Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol.
Topics: Adipose Tissue; Alkaloids; Animals; Bucladesine; Dexamethasone; Drug Synergism; Enzyme Activation; Growth Hormone; Hypophysectomy; Isoproterenol; Lipolysis; Male; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Theophylline | 1990 |
Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C.
Topics: Alkaloids; Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Dendrites; Enzyme Inhibitors; N-Methylaspartate; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
The HIV protein, GP120, activates nuclear protein kinase C in nuclei from lymphocytes and brain.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Cell Nucleus; Enzyme Activation; Hippocampus; HIV Envelope Protein gp120; Kinetics; Lymphocytes; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Spleen; Staurosporine | 1990 |
Substrate-dependent inhibition of protein kinase C by specific inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Chromatography, Affinity; Chromatography, Ion Exchange; Gossypol; Homeostasis; Isoquinolines; Kinetics; Ligands; Piperazines; Protein Kinase C; Quercetin; Rats; Sphingosine; Staurosporine; Substrate Specificity | 1990 |
Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated wi
Topics: Alkaloids; Blood; Cell Division; Cell Line; Down-Regulation; Enzyme Activation; Growth Hormone; Humans; Kinetics; Lymphocytes; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, Somatotropin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte.
Topics: Alkaloids; Animals; Arginine Vasopressin; Biological Clocks; Calcium; In Vitro Techniques; Liver; Male; Phenylephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Stimulation, Chemical; Time Factors | 1990 |
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors.
Topics: Alkaloids; Blood Platelets; Carbazoles; Diglycerides; Drug Synergism; Enzyme Activation; Feedback; Glycerides; Humans; Indole Alkaloids; Neomycin; Phosphatidic Acids; Phosphatidylcholines; Phosphorylation; Propranolol; Protein Kinase C; Second Messenger Systems; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Diacylglycerol and protein kinase mediated noradrenergic responses in perfused rat kidneys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glomerular Filtration Rate; Gluconeogenesis; Glycerides; In Vitro Techniques; Isoquinolines; Kidney; Kidney Tubules; Male; Norepinephrine; Perfusion; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Renal Circulation; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Vascular Resistance | 1990 |
Protein kinase C is present in human sperm: possible role in flagellar motility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibodies, Monoclonal; Humans; Immunohistochemistry; Isoquinolines; Kinetics; Male; Piperazines; Protein Kinase C; Reference Values; Sperm Motility; Spermatozoa; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans.
Topics: Alkaloids; Animals; Culture Techniques; Diglycerides; Glucose; Glycerides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine | 1990 |
Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Isoquinolines; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics | 1989 |
Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Azo Compounds; Cell Adhesion; Complement System Proteins; Diamide; Enzyme Activation; Erythrocytes; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Monocytes; Palmitoylcarnitine; Phagocytosis; Phosphorylation; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Complement; Sphingosine; Staurosporine; Structure-Activity Relationship | 1989 |
A further comparison of insulin- and phorbol ester-stimulated glucose transport in adipocytes.
Topics: Adenosine Triphosphate; Adipose Tissue; Alkaloids; Animals; Arsenicals; Biological Transport, Active; Cell Fractionation; Cell Survival; Deoxyglucose; Glucose; In Vitro Techniques; Insulin; Kinetics; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion.
Topics: Alkaloids; Animals; Antilymphocyte Serum; Cell Line; Interleukin-1; Interleukin-2; Mice; Phorbol Esters; Phytohemagglutinins; Protein Kinase C; Sphingosine; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.
Topics: Alkaloids; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; HeLa Cells; Hepatitis B virus; Humans; Isoquinolines; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenes; Oligodeoxyribonucleotides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Vaccinia virus; Viral Regulatory and Accessory Proteins | 1994 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effect of protein kinase C modulation on gonadotrophin-induced granulosa cell steroidogenesis.
Topics: Alkaloids; Animals; Cell Differentiation; Cyclic AMP; Female; Gonadotropins, Equine; Granulosa Cells; Pregnancy; Progesterone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Activation of transfer RNA-guanine ribosyltransferase by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Buffers; Diphosphates; Enzyme Activation; Enzyme Reactivators; Enzyme Stability; Isoquinolines; Liver; Naphthalenes; Pentosyltransferases; Phosphoric Monoester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sphingosine; Staurosporine | 1995 |
Retinoic acid induces translocation of protein kinase C (PKC) and activation of nuclear PKC (nPKC) in rat splenocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Biological Transport; Cell Nucleus; Cytosol; Enzyme Activation; Isoquinolines; Lymphocytes; Male; Nuclear Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Sphingosine; Spleen; Staurosporine; Tretinoin | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Differential sensitivity to inhibitors discriminates between two types of kinases responsible for in vivo phosphorylation of different sites in the carboxy-terminal tail of chicken neurofilament-M.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Chick Embryo; Ganglia, Spinal; Indole Alkaloids; Isoquinolines; Lithium Chloride; Molecular Sequence Data; Neurofilament Proteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sphingosine; Staurosporine; Trifluoperazine | 1994 |
N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx.
Topics: Alkaloids; Biological Transport, Active; Blood Proteins; Calcium; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Superoxides | 1995 |
Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the alpha isozyme mediates both potentiation and desensitization.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alkaloids; Aluminum Compounds; Animals; Brain; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fluorides; GTP-Binding Proteins; Humans; Isoenzymes; Isoproterenol; Kinetics; Manganese; Neuroblastoma; Neuropeptide Y; Propanolamines; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Selective down-regulation of protein kinase c-epsilon by carcinogens does not prevent stimulation of phospholipase D by phorbol ester and platelet-derived growth factor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Isoenzymes; Mice; Mice, Inbred C3H; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Platelet-Derived Growth Factor; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Involvement of second messengers in lipopolysaccharide stimulation of low density lipoprotein uptake by macrophages.
Topics: Alkaloids; Animals; Bucladesine; Cells, Cultured; Diglycerides; Enzyme Activation; Humans; Lipopolysaccharides; Lipoproteins, LDL; Macrophages; Mice; Protein Kinase C; Second Messenger Systems; Sphingosine; Staurosporine | 1994 |
Is protein kinase C activity required for the N-methyl-D-aspartate-evoked rise in cytosolic Ca2+ in mouse striatal neurons?
Topics: Alkaloids; Animals; Biological Transport; Calcium; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium Chloride; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Chelating Agents; Enzyme Activation; Hydrogen Peroxide; Hydrolysis; Mice; Phenanthrolines; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1994 |
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.
Topics: 3T3 Cells; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; Catechols; Cell Line; Cytokines; DNA-Binding Proteins; Genistein; Growth Inhibitors; Humans; Immune Sera; Interferon-gamma; Interleukin-11; Interleukin-6; Isoflavones; Kinetics; Leukemia Inhibitory Factor; Liver Neoplasms; Lymphokines; Mice; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Nitriles; Oligodeoxyribonucleotides; Oncostatin M; Peptides; Protein Kinase Inhibitors; Rats; Recombinant Proteins; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tyrphostins | 1994 |
Protein kinase C inhibitors suppress LPS-induced TNF production in alveolar macrophages and in whole blood: the role of encapsulation into liposomes.
Topics: Alkaloids; Animals; Lipopolysaccharides; Liposomes; Macrophages, Alveolar; Male; Monocytes; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tumor Necrosis Factor-alpha | 1994 |
Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Fibroblasts; Hydrogen Peroxide; Hydrolysis; Kinetics; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Sphingosine; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1994 |
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Cell Death; Cell Hypoxia; Cells, Cultured; Dibutyryl Cyclic GMP; Hippocampus; Isoquinolines; Nerve Tissue Proteins; Nitric Oxide; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides | 1993 |
Regulation of the phosphorylation of histones and glycogen synthase.
Topics: Alkaloids; AMP-Activated Protein Kinases; Animals; Arachidonic Acid; Autoradiography; Cattle; Electrophoresis, Polyacrylamide Gel; Glycogen Synthase; Guanylate Kinases; Histones; Multienzyme Complexes; Nucleoside-Phosphate Kinase; Phosphatidylethanolamines; Phosphatidylinositols; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Rabbits; Sphingosine; Staurosporine; Swine | 1993 |
Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoenzymes; Isoquinolines; Kinetics; Lysophospholipids; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulation of the receptor for platelet-activating factor on human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkaloids; Antimycin A; Blood Platelets; Calmodulin; Cyclic AMP; Deoxyglucose; Energy Metabolism; Humans; Phosphoproteins; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sphingosine; Staurosporine; Sulfonamides | 1993 |
Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector.
Topics: Alkaloids; Animals; Benzophenanthridines; Bucladesine; Diglycerides; Exocytosis; In Vitro Techniques; Lacrimal Apparatus; Male; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1993 |
Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alkaloids; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Epithelium; Indomethacin; Models, Biological; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1993 |
Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Blood Platelets; Carbazoles; Carrier Proteins; Humans; Hydrogen; Indole Alkaloids; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine; Thrombin | 1993 |
Protein kinase C: a novel target for inhibiting gastric cancer cell invasion.
Topics: Alkaloids; Amino Acid Sequence; Cell Adhesion; DNA Probes; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Sequence Data; Neoplasm Invasiveness; Polymerase Chain Reaction; Protein Kinase C; Sphingosine; Staurosporine; Stomach Neoplasms | 1993 |
Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Alkaloids; Animals; Cells, Cultured; Epithelial Cells; Epithelium; Female; Gene Expression Regulation; Genistein; Isoflavones; Isoquinolines; Mammary Glands, Animal; Milk Proteins; Phenols; Phenylacetates; Piperazines; Polymyxin B; Pregnancy; Prolactin; Protein Kinase Inhibitors; Quercetin; Rabbits; Sphingosine; Staurosporine; Succinates | 1993 |
Effects of calmodulin and protein kinase C antagonists on muscle in the filariid, Acanthocheilonema viteae.
Topics: Acetylcholine; Alkaloids; Animals; Calmodulin; Dipetalonema; Enzyme Inhibitors; Female; In Vitro Techniques; Muscle Contraction; Muscles; Phorbols; Potassium Chloride; Protein Kinase C; Sphingosine; Staurosporine; Transducers | 1995 |
Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors.
Topics: Alkaloids; Animals; Bryostatins; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Lactones; Macrolides; Models, Biological; Neoplasm Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thioguanine | 1995 |
Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.
Topics: Alkaloids; Animals; Apoptosis; Cells, Cultured; Ceramides; Chick Embryo; DNA Damage; Enzyme Inhibitors; Neurons; Protein Kinase C; Sphingomyelins; Sphingosine; Staurosporine; Time Factors | 1996 |
Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Differentiation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Sphingosine; Staurosporine; Suppression, Genetic; Tetradecanoylphorbol Acetate | 1996 |
Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Coronary Vasospasm; Cytosol; Enzyme Activation; Histamine; Interleukin-1; Male; Muscle, Smooth, Vascular; Nifedipine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Ryanodine; Sarcoplasmic Reticulum; Serotonin; Sphingosine; Staurosporine; Swine; Terpenes; Thapsigargin | 1996 |
Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Arachidonic Acid; Blood Platelets; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lysophospholipids; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Wortmannin | 1996 |
Study of protein kinase C antagonists on cortical granule exocytosis and cell-cycle resumption in fertilized mouse eggs.
Topics: Alkaloids; Animals; Benzophenanthridines; Cell Cycle; Cell Degranulation; Enzyme Inhibitors; Exocytosis; Humans; Indoles; Male; Maleimides; Mice; Phenanthridines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Zygote | 1997 |
N,N-dimethylsphingosine phosphorylation in human platelets.
Topics: Blood Platelets; Ceramides; Humans; Phosphorylation; Platelet Activation; Signal Transduction; Sphingosine; Staurosporine | 1997 |
Activation of CPP32 during apoptosis of neurons and astrocytes.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Bisbenzimidazole; Caspase 3; Caspases; Cell-Free System; Cells, Cultured; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Mice; Mice, Inbred Strains; Neurons; Poly(ADP-ribose) Polymerases; Sphingosine; Staurosporine | 1997 |
Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression.
Topics: Androgens; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Male; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Staurosporine | 1997 |
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Goldfish; Indole Alkaloids; Nerve Crush; Neurites; Okadaic Acid; Optic Nerve; Protein Kinase C; Protein Kinase Inhibitors; Retina; Sphingosine; Staurosporine | 1997 |
Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells.
Topics: Amiloride; Animals; Anti-Bacterial Agents; Cells, Cultured; Deoxyglucose; Hydrogen; Hydrogen-Ion Concentration; Macrolides; Nigericin; Ouabain; Phosphorylcholine; Pituitary Gland; Polymerase Chain Reaction; Rats; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine | 1997 |
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.
Topics: Animals; Apoptosis; Dexamethasone; DNA, Complementary; Enzyme Inhibitors; Humans; Mice; Mice, SCID; Neoplasm Proteins; Sphingosine; Staurosporine; Thapsigargin; Thioredoxins; Transfection; Tumor Cells, Cultured | 1997 |
Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Enzyme Activation; Half-Life; Humans; Indoles; Maleimides; Nasopharyngeal Neoplasms; Protein Kinase C; Protein Synthesis Inhibitors; Sphingosine; Staurosporine; Telomerase; Tumor Cells, Cultured | 1997 |
Increases in acetylcholine release produced by phorbol esters are not mediated by protein kinase C at motor nerve endings.
Topics: Acetylcholine; Animals; Carcinogens; Enzyme Inhibitors; Naphthalenes; Neuromuscular Junction; Phorbol Esters; Protein Kinase C; Rana pipiens; Sphingosine; Staurosporine | 1998 |
Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine.
Topics: Animals; Calcimycin; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Masoprocol; Mice; Neutrophils; Protein Kinase C; Reactive Oxygen Species; Sphingosine; Staurosporine | 1997 |
Adenosine 5'-triphosphate, uridine 5'-triphosphate, bradykinin, and lysophosphatidic acid induce different patterns of calcium responses by human articular chondrocytes.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Calcium-Binding Proteins; Cartilage, Articular; Chondrocytes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Interleukin-1; Ligands; Lysophospholipids; Purinergic Agonists; Receptors, Cell Surface; Recombinant Proteins; Sphingosine; Staurosporine; Thapsigargin; Uridine Triphosphate | 1998 |
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes | 1998 |
Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic.
Topics: Animals; Apoptosis; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Free Radical Scavengers; Metalloporphyrins; Neurons; Rats; Sphingosine; Staurosporine; Superoxide Dismutase | 1998 |
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway.
Topics: Adenosine Triphosphate; Animals; Aorta; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; DNA; Enzyme Activation; Enzyme Inhibitors; Estrenes; Inositol 1,4,5-Trisphosphate; Kinetics; Lysophospholipids; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase C; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Swine; Thapsigargin; Virulence Factors, Bordetella | 1998 |
Influence of probes for calcium-calmodulin and protein kinase C signalling on the plasma membrane Ca2+-ATPase activity of rat synaptosomes and leukocyte membranes.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Enzyme Inhibitors; Gallic Acid; Imidazoles; Leukocytes; Male; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Staurosporine; Synaptosomes | 1998 |
Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator.
Topics: Animals; Apoptosis; Aryl Hydrocarbon Receptor Nuclear Translocator; DNA-Binding Proteins; Doxorubicin; Liver Neoplasms, Experimental; Mice; Receptors, Aryl Hydrocarbon; Sphingosine; Staurosporine; Transcription Factors; Tumor Cells, Cultured | 1999 |
Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells.
Topics: Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Epithelial Cells; GTP-Binding Proteins; Histamine; Humans; Inositol Phosphates; Lysophospholipids; Magnesium; Nasal Cavity; Palmitic Acid; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Staurosporine; Thapsigargin; Time Factors; Virulence Factors, Bordetella | 1998 |
CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide.
Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Ceramides; Cyclins; Dose-Response Relationship, Drug; Etoposide; Humans; Membrane Glycoproteins; Models, Biological; Molecular Chaperones; Neurodegenerative Diseases; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Sphingosine; Staurosporine; Time Factors; Transfection; Vincristine | 1999 |
Phospholipid signalling pathways in Trypanosoma cruzi growth control.
Topics: Adenylate Cyclase Toxin; Animals; Benzylamines; Carbazoles; Cell Division; Culture Media; Cyclic AMP; Dose-Response Relationship, Drug; Estrenes; Indoles; Lysophospholipids; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Protein Kinases; Pyrroles; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides; Trypanosoma cruzi; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis.
Topics: Animals; Apoptosis; Caspases; Dexamethasone; Enzyme Inhibitors; fas Receptor; Glucocorticoids; Humans; Mice; Mutagenesis; Sphingosine; Staurosporine; Tumor Cells, Cultured | 1999 |
Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cyclic AMP; Egtazic Acid; Estrenes; Imidazoles; Ionomycin; Manganese; Muscle, Smooth, Vascular; Phosphorylcholine; Pyrrolidinones; Sphingosine; Staurosporine; Swine; Thapsigargin; Thionucleosides; Thionucleotides; Virulence Factors, Bordetella | 2000 |
Entamoeba invadens: protein kinase C inhibitors block the growth and encystation.
Topics: Alkaloids; Animals; Benzophenanthridines; Entamoeba; Enzyme Inhibitors; Naphthalenes; Phenanthridines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Selective protein kinase inhibitors block head-specific differentiation in hydra.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoquinones; Carrier Proteins; Cell Cycle; Humans; Hydra; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Protein Kinase C; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Sphingosine; Staurosporine | 2000 |
Streptolysin O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral sphingomyelinase.
Topics: Bacterial Proteins; Cell Membrane Permeability; Ceramides; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Granulocytes; Humans; Hydroxamic Acids; Isoenzymes; L-Selectin; N-Formylmethionine Leucyl-Phenylalanine; Phenanthrolines; Phosphotransferases (Alcohol Group Acceptor); Second Messenger Systems; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Streptolysins | 2000 |
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Daunorubicin; Enzyme Inhibitors; Etoposide; Humans; Infant; Morpholines; Nerve Degeneration; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Neurons; Nucleic Acid Synthesis Inhibitors; Sphingosine; Staurosporine; Thiolester Hydrolases; Transfection; Tumor Cells, Cultured | 2001 |
Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Intracellular Membranes; Membrane Potentials; Mice; Microscopy, Confocal; Mitochondria; Neurons; Oxidative Stress; Phosphorylation; Precipitin Tests; Pyruvic Acid; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Sphingosine; Staurosporine; Succinic Acid; Time Factors | 2003 |
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glioma; Glycoconjugates; Glycosylation; Humans; Morpholines; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialyltransferases; Sphingosine; Staurosporine; Transfection | 2004 |
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Biotransformation; Blotting, Western; Cells, Cultured; Colforsin; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Protein Kinases; Purinergic Agonists; Purinergic P1 Receptor Agonists; Rats; Receptors, Lysosphingolipid; Sphingosine; Staurosporine | 2004 |
Sphingosine 1-phosphate breakdown in platelets.
Topics: Blood Platelets; Cell Membrane; Ceramides; Chromatography, High Pressure Liquid; Humans; Lysophospholipids; Models, Biological; Phosphatidate Phosphatase; Phosphorylation; Platelet Activation; Platelet Aggregation; Signal Transduction; Sphingolipids; Sphingomyelins; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors | 2004 |
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.
Topics: Androstadienes; Animals; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 8; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Membrane Microdomains; Oligodendroglioma; PC12 Cells; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Rats; Sphingosine; Staurosporine; Transfection; Tumor Suppressor Proteins; Wortmannin | 2005 |
A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3.
Topics: Animals; Carbazoles; Carcinogens; Diterpenes; Enzyme Inhibitors; Hippocampus; Indoles; Isoenzymes; Lactams; Long-Term Potentiation; Male; Protein Kinase C; Rats; Rats, Wistar; Sphingosine; Staurosporine | 2005 |
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Humans; Jurkat Cells; Lysophospholipids; Macrophages; Mice; RNA, Small Interfering; Sphingosine; Staurosporine | 2006 |
L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Female; Humans; Neural Cell Adhesion Molecule L1; Ovarian Neoplasms; Sphingosine; Staurosporine; Transfection | 2007 |
Trypanosoma cruzi epimastigotes: regulation of myo-inositol transport by effectors of protein kinases A and C.
Topics: Animals; Biological Transport; Bucladesine; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Inositol; Kinetics; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sphingosine; Staurosporine; Trypanosoma cruzi | 2007 |
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Line, Tumor; Cell Polarity; Cell Survival; Coculture Techniques; Cytokines; Humans; Lysophospholipids; Macrophage Activation; Macrophages; Neoplasms; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Staurosporine | 2007 |
Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death.
Topics: alpha-Crystallin A Chain; alpha-Crystallin B Chain; Animals; Astrocytes; Cell Death; Cell Line; Cells, Cultured; Humans; Immunoprecipitation; Insecta; Protein Binding; Rats; Receptor, PAR-2; Sphingosine; Staurosporine | 2009 |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
Topics: Animals; Apoptosis; Aspartic Acid; Calcimycin; Hydrogen Peroxide; Hypotonic Solutions; Ion Channels; Ionophores; Nitrobenzoates; PC12 Cells; Rats; Sphingosine; Staurosporine; Stereoisomerism; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uric Acid | 2009 |
Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sphingosine; Staurosporine | 2011 |
Targeting sphingosine kinase-1 to inhibit melanoma.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Humans; Lysophospholipids; Melanocytes; Melanoma; Mice; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; RNA, Small Interfering; Skin Neoplasms; Sphingosine; Staurosporine; Thiazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity.
Topics: alpha-Crystallin A Chain; Animals; Astrocytes; Cell Survival; Phosphorylation; Primary Cell Culture; Rats; Rats, Wistar; Sphingosine; Staurosporine | 2012 |
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Anticarcinogenic Agents; Benzopyrans; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Oleanolic Acid; Precursor Cells, B-Lymphoid; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2012 |
Protein kinase C signaling molecules regulate encystation of Acanthamoeba.
Topics: Acanthamoeba castellanii; Benzophenanthridines; Gene Silencing; Isoenzymes; Phylogeny; Protein Kinase C; Real-Time Polymerase Chain Reaction; Sequence Alignment; Sphingosine; Staurosporine | 2012 |
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Etoposide; Gene Expression Regulation; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Immunoprecipitation; Neural Inhibition; Neuroblastoma; Neurons; Peptide Fragments; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Rats; Signal Transduction; Sphingosine; Staurosporine; Transfection | 2012 |
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
Topics: Alternative Splicing; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-X Protein; Brain Injuries; CELF1 Protein; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Functional Laterality; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Male; Mice; Neurons; Pregnancy; Rats; RNA Precursors; RNA-Binding Proteins; RNA, Small Interfering; Sphingosine; Staurosporine; Time Factors; Transfection | 2012 |
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cisplatin; Gene Expression Regulation, Neoplastic; Humans; Kv1.1 Potassium Channel; Kv1.3 Potassium Channel; Mitochondria; Neoplasms; Potassium Channel Blockers; RNA, Messenger; Sphingosine; Staurosporine; Tumor Burden | 2014 |
Loss of Bcl-2 expression correlates with increasing sensitivity to apoptosis in differentiating ES cells.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Embryonic Stem Cells; Membrane Potential, Mitochondrial; Mice; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Staurosporine | 2014 |
Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria.
Topics: alpha-Crystallins; Animals; Antimycin A; Astrocytes; Brain; Cell Death; Cell Survival; Cells, Cultured; Escherichia coli; Extracellular Space; MAP Kinase Signaling System; Mitochondria; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Sphingosine; Staurosporine; TOR Serine-Threonine Kinases | 2015 |