staurosporine has been researched along with sirolimus in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Behl, A; Bhat, KA; Chakraborty, S; Chikan, NA; Farooq, S; Goswami, A; Lone, SH; Mondhe, DM; Nayak, D; Rah, B; Rasool, RU | 1 |
| Afratis, K; Gavras, H; Karamanos, NK; Koutsakis, C; Leonardi, S; Papaioannou, D; Piperigkou, Z; Rassias, G; Rigopoulou, D; Vachlioti, E | 1 |
| Carey, GB; Liberti, JP | 1 |
| Kleijn, M; Korthout, MM; Thomas, AA; Voorma, HO | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Foncea, R; Lavandero, S; Pérez, V; Sapag-Hagar, M | 1 |
| del Valle, J; Grand, E; Todisco, A; Wang, LD; Wang, M | 1 |
| Fox, HL; Heydrick, SJ; Jefferson, LS; Kimball, SR; Lynch, CJ; Pham, PT | 1 |
| Proud, CG; Tee, AR | 1 |
| Chodosh, LA; Cinalli, RM; Fox, CJ; Hammerman, PS; Master, SR; Thompson, CB | 1 |
| Boulton, C; Gilliland, DG; Griffin, JD; Gu, TL; Mohi, MG; Neel, BG; Neuberg, D; Sternberg, DW | 1 |
| Dent, P; Grant, S; Hahn, M; Li, W; Rahmani, M; Yu, C | 1 |
| Aoki, H; Fujiwara, K; Kanzawa, T; Kondo, S; Kondo, Y; Mills, GB; Takeuchi, H | 1 |
| Fauconnier, J; Lacampagne, A; Rauzier, JM; Richard, S; Vassort, G | 1 |
| Allenspach, R; Erne, P; Ivanov, D; Joshi, MB; Philippova, M; Resink, TJ | 1 |
| Barten, MJ; Boldt, A; Gummert, JF; Mohr, FW; Sagner, A; Weiss, C | 1 |
| von Mehren, M | 1 |
| Aguilera, N; Auerbach, A; Burger, AM; D'Costa, AM; Jiang, F; Rapoport, AP; Sands, AM; Sausville, EA; Stass, SA; Zhao, MY; Zhao, XF | 1 |
| Esser, J; Gabrielsson, S; Gehrmann, U; Haeggström, JZ; Rådmark, O; Salvado, MD; Samuelsson, B; Scheynius, A; Wetterholm, A | 1 |
| Chen, Y; Deng, X; Fang, Z; Lin, J; Sheng, F; Wei, Y; Xia, B; Zhong, W; Zhou, C; Zhou, J | 1 |
| Lipinski, MM; Xu, Y; Yuan, J | 1 |
| Huang, RC; Kimura, K | 1 |
| Al Mamun Bhuyan, A; Cao, H; Lang, F | 1 |
| Cao, YJ; Du, WX; Huang, YB; Liu, CF; Liu, HH; Shi, LY; Sun, JJ; Wang, F; Yin, XW; Zhang, YL | 1 |
1 review(s) available for staurosporine and sirolimus
| Article | Year |
|---|---|
Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Bevacizumab; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Everolimus; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Niacinamide; Oligonucleotides; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sirolimus; Staurosporine; Sunitinib; Thiazoles | 2006 |
24 other study(ies) available for staurosporine and sirolimus
| Article | Year |
|---|---|
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Diterpenes; Drug Design; Female; Halogenation; Humans; Membrane Proteins; Mice; Proto-Oncogene Proteins c-bcl-2; Salvia; Sarcoma 180; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Topics: Anti-Bacterial Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Quinolines; Receptor, Bradykinin B2 | 2021 |
Stimulation of receptor-associated kinase, tyrosine kinase, and MAP kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in Nb2 lymphoma.
Topics: Alkaloids; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Genistein; Isoflavones; Janus Kinase 2; Lymphocyte Activation; Lymphoma; Molecular Sequence Data; Polyenes; Prolactin; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Signal Transduction; Sirolimus; Staurosporine; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
Phosphorylation of the eIF4E-binding protein PHAS-I after exposure of PC12 cells to EGF and NGF.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Eukaryotic Initiation Factor-4E; Immunophilins; Intracellular Signaling Peptides and Proteins; Nerve Growth Factors; PC12 Cells; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Wortmannin | 1996 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phosphorylation; Polyenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Sirolimus; Staurosporine; Wortmannin | 1998 |
The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner.
Topics: Androstadienes; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genes, jun; Histamine; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Histamine H2; Recombinant Proteins; RNA, Messenger; Sirolimus; Staurosporine; Transfection; Wortmannin | 2000 |
Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.
Topics: Adenosine Diphosphate Ribose; Adipocytes; Aluminum; Amino Acids; Animals; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Fluorine; GTP-Binding Protein alpha Subunits, Gi-Go; Histidinol; Insulin; Intracellular Signaling Peptides and Proteins; Leucine; Male; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Virulence Factors, Bordetella | 2000 |
Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Caspases; Cell Cycle Proteins; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factors; Insulin; Mice; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Kinases; Proteins; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases | 2001 |
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Genetic Vectors; Glucose; Interleukin-3; Lactates; Membrane Potentials; Mice; Mitochondria; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Signal Transduction; Sirolimus; Staurosporine; Thapsigargin; Time Factors; Transcription, Genetic; Transgenes | 2003 |
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Benzamides; Cell Division; Cell Line, Tumor; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Sirolimus; Staurosporine | 2004 |
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Caspases; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin D1; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genes, Dominant; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Sirolimus; Staurosporine; Time Factors; U937 Cells | 2005 |
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inhibitors; Glioma; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases | 2005 |
Ca2+-dependent reduction of IK1 in rat ventricular cells: a novel paradigm for arrhythmia in heart failure?
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Depression, Chemical; Egtazic Acid; Heart Failure; Immunosuppressive Agents; Male; Myocardial Infarction; Myocardium; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sirolimus; Staurosporine; Tacrolimus | 2005 |
T-cadherin protects endothelial cells from oxidative stress-induced apoptosis.
Topics: Adenoviridae; Androstadienes; Apoptosis; Cadherins; Caspases; Cell Survival; Cells, Cultured; Dactinomycin; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoblotting; Immunohistochemistry; Immunosuppressive Agents; MAP Kinase Signaling System; Microscopy, Fluorescence; Models, Biological; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Sirolimus; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2005 |
Novel apoptosis assay to analyze immunosuppression.
Topics: Annexin A5; Apoptosis; Cyclosporine; Flow Cytometry; Humans; Immunosuppression Therapy; Immunosuppressive Agents; In Situ Nick-End Labeling; Lymphocytes; Mycophenolic Acid; Sirolimus; Staurosporine; Tacrolimus | 2006 |
Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; CDC2 Protein Kinase; Cell Proliferation; Cyclin B; Cyclin-Dependent Kinases; Drug Synergism; Female; Flow Cytometry; G1 Phase; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Neoplasm Recurrence, Local; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2009 |
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.
Topics: Aspirin; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Glutathione Transferase; Humans; Leukotriene C4; Macrophages; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Prostaglandin E; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Staurosporine; Toll-Like Receptor 2; Zymosan | 2011 |
Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells.
Topics: Animals; Autophagy; Cisplatin; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Fluorescence; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Lysosomes; Mice; Microscopy, Confocal; Microtubule-Associated Proteins; Neoplasms; Recombinant Fusion Proteins; Red Fluorescent Protein; Sirolimus; Staurosporine | 2012 |
Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis.
Topics: Animals; Apoptosis; Autophagy; Cell Division; HeLa Cells; Humans; Imaging, Three-Dimensional; Kinetics; Mice; Single-Cell Analysis; Sirolimus; Staurosporine; Time-Lapse Imaging | 2013 |
Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.
Topics: Antineoplastic Agents; Autophagy; Carbohydrate Metabolism; Caspase 7; Cell Line, Tumor; Down-Regulation; Drug Synergism; Energy Metabolism; Etoposide; Glutathione; Humans; Lipid Metabolism; Male; Masoprocol; Metabolic Networks and Pathways; Metabolome; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sirolimus; Staurosporine | 2016 |
Triggering of Eryptosis, the Suicidal Erythrocyte Death by Mammalian Target of Rapamycin (mTOR) inhibitor Temsirolimus.
Topics: Aniline Compounds; Annexin A5; Antineoplastic Agents; Benzamides; Benzophenanthridines; Calcium; Casein Kinase I; Caspases; Ceramides; Eryptosis; Erythrocytes; Fluoresceins; Gene Expression Regulation; Hemolysis; Humans; Imidazoles; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphatidylserines; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; Signal Transduction; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Xanthenes | 2017 |
Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway.
Topics: Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; E-Selectin; Gene Knockdown Techniques; Genes, fos; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Mechanistic Target of Rapamycin Complex 2; Protein Kinase C; Rapamycin-Insensitive Companion of mTOR Protein; Regulatory-Associated Protein of mTOR; RNA, Small Interfering; Signal Transduction; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate | 2018 |