staurosporine has been researched along with ro 31-8220 in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 50 (67.57) | 18.2507 |
| 2000's | 21 (28.38) | 29.6817 |
| 2010's | 2 (2.70) | 24.3611 |
| 2020's | 1 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Flajolet, M; Greengard, P; Meijer, L | 1 |
| Black, J; Fleming, M; Futer, O; Hare, B; Jacobs, MD; Saxena, K; Swenson, L | 1 |
| Bullock, AN; Debreczeni, JE; Fedorov, OY; Knapp, S; Marsden, BD; Nelson, A | 1 |
| Goekjian, P; Jochum, A; Jung, M; Kunick, C; Marshall, B; Meier, R; Saunders, L; Sippl, W; Trapp, J; Verdin, E | 1 |
| Jagarlapudi, SA; Sinha, BN; Tajne, S; Vadivelan, S | 1 |
| Amin, S; Jaiswal, AS; Law, BK; Narayan, S; Ramisetti, S; Sharma, AK; Singh, P; Singh-Pillay, A | 1 |
| Bennett, J; Berger, BT; Collins, RJ; Elkins, JM; Fedorov, O; Knapp, S; Massirer, KB; Patel, H; Serafim, RAM; Sorrell, FJ; Vasconcelos, SNS; Zuercher, WJ | 1 |
| Gilfillan, AM; Lin, P | 1 |
| Joseph, S; MacDermot, J | 1 |
| Carew, MA; Paleolog, EM; Pearson, JD | 1 |
| Dieter, P; Fitzke, E | 1 |
| Chollet, A; Nemeth, K | 1 |
| Jones, KT; Sharpe, GR | 1 |
| Budworth, J; Gescher, A | 1 |
| Bunn, SJ; Saunders, HI | 1 |
| Abayasekara, RE; Flint, AP; Searle, MJ | 1 |
| Finney, M; Gordon, J; Katira, A; Knox, KA; Michell, RH; Wakelam, M | 1 |
| Henderson, LK; Matthews, N; Nemec, M; Southern, C; Thorp, KM; Wilkinson, PC | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Lutz, EM; Mitchell, R; Simpson, J | 1 |
| Hall, IP; Hill, SJ; McCreath, G | 1 |
| Rodríguez-Liñares, B; Watson, SP | 1 |
| Jones, PM; Persaud, SJ | 1 |
| Keller, HU; Niggli, V | 1 |
| Alverez, J; Garcia-Sancho, J; Montero, M | 1 |
| Cordier, J; Glowinski, J; Murphy, NP; Prémont, J | 1 |
| Bonin, L; Chen, B; Griffith, OH; Hedberg, K; Mobley, PL | 1 |
| Dangelmaier, C; Daniel, JL; Smith, JB | 1 |
| Holden, CM; Mallon, BS; Rumsby, MG; Thompson, HJ; Turner, RA | 1 |
| Litherland, GJ; Mallon, BS; Rumsby, MG; Thompson, HJ | 1 |
| Asselin, J; Blake, RA; Walker, T; Watson, SP | 1 |
| Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R | 1 |
| Nixon, JS; Parker, PJ; Wilkinson, SE | 1 |
| Drew, L; Rumsby, MG; Warr, JR | 1 |
| Fenton, JA; Rumsby, MG; Warr, JR | 1 |
| Edwards, SW; Galvani, DW; Lowe, GM; Slupsky, JR | 1 |
| Budworth, J; Davies, R; Ferry, DR; Gant, TW; Gescher, A; Malkhandi, J | 1 |
| Ahmed, A; Dearn, SR; Morrison, JJ; Smith, SK | 1 |
| Cockram, CS; Ho, SK; Nicholls, MG; Tsang, DS; Yeung, VT | 1 |
| Hall, N; Kelleher, D; Liskamp, RM; Long, A; O'Connell, MA; O'Neill, LA | 1 |
| Akbar, AN; Bacon, PA; Pilling, D; Salmon, M; Shamsadeen, N | 1 |
| Cousin, JM; Haslett, C; Rossi, AG | 1 |
| Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM | 1 |
| Mahon, TM; Matthews, JS; O'Neill, LA | 1 |
| Courage, C; Gescher, A; Hubbard, A; Jones, T | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Bradder, SM; Courage, C; Gescher, A; Jones, T; Schultze-Mosgau, MH | 1 |
| Verspohl, EJ; Wienecke, A | 1 |
| Breitbart, H; Luria, A; Rubinstein, S; Sun, QY | 1 |
| Aldershvile, J; Bauersachs, J; Busse, R; Fleming, I; Schäfer, A; Scholz, D | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Martin, WH; Peterson, MF; Spencer, RW; Tate, BF | 1 |
| Gordon, R; Haefner, B; Hoefnagel, E; Masure, S; Mortier, E; Richardson, A; Tuytelaars, A; Verhasselt, P; Wesselink, JJ | 1 |
| Choy, PC; Geiger, JD; Golfman, LS; Haughey, NJ; Jiang, JY; Lee, D; Wong, JT | 1 |
| Chang, SH; Lin, WW; Wang, SM | 1 |
| Alcántara-Hernández, R; Gárcia-Sáinz, JA; Vázquez-Prado, J | 1 |
| Ahn, JS; Ahn, SC; Han, YJ; Kang, DO; Kim, BY; Kim, JH; Ko, HR; Lee, HS; Mheen, TI; Oh, WK | 1 |
| Han, Z; Hendrickson, EA; Lange, TS; Pantazis, P; Wyche, JH | 1 |
| del Carmen Medina, L; García-Sáinz, JA; Vázquez-Prado, J | 1 |
| Chen, CC; Chen, JJ; Chou, CY | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Chen, JS; Song, JG | 1 |
| Gauvreau, G; MacGlashan, DW; Miura, K; Saini, SS | 1 |
| Flores-Jasso, CF; García-Sáinz, JA; Romero-Avila, MT | 1 |
| Bazuine, M; Bosch, RR; Hermus, AR; Maassen, JA; Olthaar, AJ; Schürmann, A; Span, PN; Sweep, CG; Wake, MM; Willems, PH | 1 |
| Bauer, J; Parekh, N | 1 |
| Searl, TJ; Silinsky, EM | 1 |
| Cunningham, FM; Goode, NT; Greenaway, EC; Sepulveda, MF | 1 |
| Alvarez, J; Gutierrez-Fernández, S; Lobatón, CD; Montero, M; Moreno, A | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Namiki, H; Takahashi, H | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B; Turowska, A | 1 |
| Barcia, R; Barcia-Sanjurjo, I; Lazo, PA; Sanz-García, M; Vázquez-Cedeira, M | 1 |
1 review(s) available for staurosporine and ro 31-8220
| Article | Year |
|---|---|
Pharmacological inhibitors of glycogen synthase kinase 3.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Neoplasms; Nervous System Diseases; Parasitic Diseases; Signal Transduction; Stem Cells; Structure-Activity Relationship | 2004 |
73 other study(ies) available for staurosporine and ro 31-8220
| Article | Year |
|---|---|
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Sequence Alignment; Staurosporine | 2005 |
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Topics: Antineoplastic Agents; Crystallization; Crystallography, X-Ray; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Models, Molecular; Molecular Structure; Moloney murine leukemia virus; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-pim-1; Proviruses; Pyrazoles; Pyridazines; Pyrimidines; Structure-Activity Relationship | 2005 |
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Topics: Acetylation; Adenosine; Binding Sites; Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Mimicry; Protein Kinase Inhibitors; Sirtuins; Structure-Activity Relationship; Tubulin | 2006 |
Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.
Topics: Algorithms; Computer Simulation; Databases, Factual; Drug Design; Drug Evaluation, Preclinical; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Models, Chemical; Models, Molecular; Molecular Structure; Oxazines; Protein Kinase Inhibitors; Quinazolines; Reproducibility of Results; Stereoisomerism; Structure-Activity Relationship | 2009 |
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.
Topics: Adamantane; Antineoplastic Agents; Aza Compounds; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Molecular Structure; Oxaliplatin; Stem Cells; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Topics: Aniline Compounds; Binding Sites; Cell Line, Tumor; Cell Movement; HEK293 Cells; Humans; Maleimides; Microfilament Proteins; Molecular Docking Simulation; Molecular Structure; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Structure-Activity Relationship | 2021 |
The role of calcium and protein kinase C in the IgE-dependent activation of phosphatidylcholine-specific phospholipase D in a rat mast (RBL 2H3) cell line.
Topics: Alkaloids; Animals; Calcium; Cell Line; Enzyme Activation; Histamine Release; Immunoglobulin E; Indoles; Ionomycin; Kinetics; Maleimides; Mast Cells; Phospholipase D; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization.
Topics: Actins; Alkaloids; Calcium; Cations, Divalent; Cell Line; Chemotaxis, Leukocyte; GTP-Binding Proteins; Humans; Indoles; Ionomycin; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Polymers; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella | 1992 |
The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcimycin; Calcium; Cations, Divalent; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Indoles; Maleimides; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; von Willebrand Factor | 1992 |
RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages.
Topics: Alkaloids; Animals; Cells, Cultured; Dinoprostone; Indoles; Kinetics; Macrophages; Maleimides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
A single mutation of the neurokinin-2 (NK2) receptor prevents agonist-induced desensitization. Divergent conformational requirements for NK2 receptor signaling and agonist-induced desensitization in Xenopus oocytes.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Calcium; Cell Membrane; DNA Primers; Enzyme Inhibitors; Female; Humans; Ileum; In Vitro Techniques; Indoles; Kinetics; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Neurokinin A; Oocytes; Peptide Fragments; Piperidines; Point Mutation; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Receptors, Neurokinin-2; Recombinant Proteins; Sequence Deletion; Signal Transduction; Staurosporine; Time Factors; Xenopus | 1995 |
Staurosporine, a non-specific PKC inhibitor, induces keratinocyte differentiation and raises intracellular calcium, but Ro31-8220, a specific inhibitor, does not.
Topics: Alkaloids; Calcium; Cell Differentiation; Cell Division; Humans; Indoles; Intracellular Membranes; Keratinocytes; Protein Kinase C; Protein Precursors; Staining and Labeling; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
Topics: Alkaloids; Breast Neoplasms; Cell Membrane; Cytosol; Humans; Immunoblotting; Indoles; Naphthalenes; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
Staurosporine inhibits inositol phosphate formation in bovine adrenal medullary cells.
Topics: Adrenal Medulla; Alkaloids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Histamine; Indoles; Inositol Phosphates; Isoquinolines; Norepinephrine; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Type C Phospholipases | 1995 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
Inhibition by glucocorticoid and staurosporine of IL-4-dependent CD23 production in B lymphocytes is reversed on engaging CD40.
Topics: Alkaloids; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; CD40 Antigens; Cells, Cultured; Genistein; Humans; In Vitro Techniques; Indoles; Interleukin-4; Isoflavones; Prednisolone; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, IgE; Recombinant Proteins; Signal Transduction; Staurosporine | 1993 |
Inhibition of protein kinase C results in a switch from a non-motile to a motile phenotype in diverse human lymphocyte populations.
Topics: Alkaloids; B-Lymphocytes; Blotting, Western; Cell Line; Cell Movement; Cells, Cultured; Enzyme Activation; Humans; Indoles; Lymphocytes; Maleimides; Marine Toxins; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Protein Kinase C; Staurosporine; T-Lymphocytes | 1995 |
A novel high molecular weight form of protein kinase C in anterior pituitary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Indoles; Isoenzymes; Isoquinolines; Kinetics; Molecular Weight; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Staurosporine | 1995 |
Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells.
Topics: Alkaloids; Cells, Cultured; Colforsin; Endothelium, Vascular; Histamine; Humans; Hydrolysis; Indoles; Nitroprusside; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Receptors, Histamine H1; Sodium Fluoride; Staurosporine; Umbilical Veins | 1994 |
Phosphorylation of JAK2 in thrombin-stimulated human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Chelating Agents; Egtazic Acid; In Vitro Techniques; Indoles; Janus Kinase 2; Kinetics; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Staurosporine; Styrenes; Thrombin; Vanadates | 1994 |
Inhibition of insulin release by staurosporine and Ro 31-8220: a role for protein kinase C?
Topics: Alkaloids; Animals; In Vitro Techniques; Indoles; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Protein Kinase C; Rats; Staurosporine | 1994 |
Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41,251 on PMN locomotion, cell polarity, and pinocytosis.
Topics: Alkaloids; Amino Acid Sequence; Cell Movement; Cell Polarity; Cell Size; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Indoles; Molecular Sequence Data; Molecular Weight; Neutrophils; Oligopeptides; Phosphoproteins; Pinocytosis; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine | 1994 |
Is protein kinase C activity required for the N-methyl-D-aspartate-evoked rise in cytosolic Ca2+ in mouse striatal neurons?
Topics: Alkaloids; Animals; Biological Transport; Calcium; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium Chloride; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Decreased phosphorylation of four 20-kDa proteins precedes staurosporine-induced disruption of the actin/myosin cytoskeleton in rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Animals, Newborn; Astrocytes; Azepines; Cells, Cultured; Cytoskeleton; Indoles; Isoquinolines; Myosin-Light-Chain Kinase; Myosins; Nerve Tissue Proteins; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine | 1994 |
Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization.
Topics: Alkaloids; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; Indoles; Inositol Phosphates; Phosphatidic Acids; Phosphorylation; Platelet Aggregation Inhibitors; Precipitin Tests; Serotonin; Signal Transduction; Staurosporine; Type C Phospholipases; Tyrosine | 1994 |
Protein kinase C activation of phospholipase D in C6 glioma cells.
Topics: Alkaloids; Animals; Cell Line; Enzyme Activation; Glioma; Indoles; Phorbol Esters; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Staurosporine and its derivative RO31-8220, both inhibitors of protein kinase C, have different effects on C6 glioma cell morphology.
Topics: Alkaloids; Cell Line; Glioma; Indoles; Molecular Weight; Phosphoproteins; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Blood Platelets; Egtazic Acid; Humans; Indoles; Inositol Phosphates; Phosphorylation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Staurosporine; Styrenes; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine | 1994 |
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Indoles; Isoquinolines; Lung; Male; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes | 1993 |
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Indoles; Isoenzymes; Maleimides; Molecular Conformation; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship | 1993 |
A role for protein kinase C in the multidrug resistance phenotype of human carcinoma KB cell lines.
Topics: Alkaloids; Biological Transport, Active; Colchicine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Indoles; Phenotype; Protein Kinase C; Staurosporine; Tumor Cells, Cultured; Vinblastine | 1995 |
The relationship between protein kinase C subspecies and multidrug resistance in vincristine resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; CHO Cells; Choline; Cricetinae; Drug Resistance, Multiple; Indoles; Isoenzymes; Kinetics; Phospholipids; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vincristine | 1995 |
GTPgammaS-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not tyrosine kinases.
Topics: Alkaloids; Benzylidene Compounds; Cell Membrane Permeability; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroquinones; In Vitro Techniques; Indoles; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nitriles; Phospholipase D; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1996 |
Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Division; Cell Line; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Maleimides; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine | 1996 |
Activation of protein kinase C is required for oxytocin-induced contractility in human pregnant myometrium.
Topics: Adult; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Humans; In Vitro Techniques; Indoles; Isoflavones; Myometrium; Oxytocin; Phospholipase D; Pregnancy; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Uterine Contraction | 1996 |
Endothelin-3 attenuates the cyclic GMP responses to C-type natriuretic peptide in cultured mouse astrocytes.
Topics: Adenosine Diphosphate Ribose; Animals; Astrocytes; Atrial Natriuretic Factor; Binding, Competitive; Calcimycin; Calcium; Cells, Cultured; Cyclic GMP; Cycloheximide; Dose-Response Relationship, Drug; Endothelin-3; Enzyme Inhibitors; Indoles; Ionophores; Mice; Natriuretic Peptide, C-Type; Phospholipase D; Phospholipases A; Phosphoprotein Phosphatases; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proteins; Staurosporine; Type C Phospholipases | 1996 |
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
The regulation of apoptosis in resting T lymphocytes.
Topics: Apoptosis; Blood; Cells, Cultured; Culture Media; Enzyme Inhibitors; Eosinophils; Growth Substances; Humans; Indoles; Kinetics; Lymphocyte Activation; Neutrophils; Oligopeptides; Protein Kinase C; Signal Transduction; Staurosporine; T-Lymphocytes | 1997 |
Regulation of granulocyte apoptosis by PKC inhibition and elevation of [Ca2+]i.
Topics: Apoptosis; Calcimycin; Calcium; Cells, Cultured; Enzyme Inhibitors; Eosinophils; Humans; Indoles; Kinetics; Neutrophils; Protein Kinase C; Staurosporine; Thapsigargin | 1997 |
Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo.
Topics: Animals; Calcium; Cell Aggregation; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Enzyme Inhibitors; Eosinophils; Female; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoenzymes; Isoquinolines; Leukotriene B4; Pertussis Toxin; Phospholipase C beta; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
Topics: Animals; Cell Membrane; Cytosol; Drug Synergism; Enzyme Inhibitors; Indoles; Interleukin-1; Interleukin-2; Isoenzymes; Kinetics; Mice; NF-kappa B; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Time Factors; Tumor Cells, Cultured | 1997 |
Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues.
Topics: Alkaloids; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Indoles; Isoenzymes; Maleimides; Microscopy, Confocal; Models, Chemical; Protein Kinase C; Protein Kinase C-theta; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc Fingers | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine.
Topics: Adenocarcinoma; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indoles; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1997 |
The role of protein kinase C in the desensitization of rat pancreatic islets to cholinergic stimulation.
Topics: Analysis of Variance; Animals; Carbachol; Enzyme Inhibitors; Female; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muscarinic Agonists; Peptide Fragments; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase inhibitors induce the interphase transition by inactivating mitogen-activated protein kinase in mouse eggs.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Genistein; Immunoblotting; Indoles; Interphase; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Ovum; Protein-Tyrosine Kinases; Staurosporine | 1998 |
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Benzoquinones; Calcium; Calmodulin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Hydroquinones; Imidazoles; In Vitro Techniques; Indoles; Isometric Contraction; Lactams, Macrocyclic; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Oxazines; Quinones; Rabbits; Rifabutin; Staurosporine | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
The use of beta, gamma-methyleneadenosine 5'-triphosphate to determine ATP competition in a scintillation proximity kinase assay.
Topics: Adenosine Triphosphate; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Indoles; Kinetics; Kinetin; Protein Kinase Inhibitors; Purines; Scintillation Counting; Staurosporine | 1999 |
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3.
Topics: Amino Acid Sequence; Animals; Chromosome Mapping; Chromosomes, Human, Pair 1; Cloning, Molecular; Enzyme Activation; Humans; In Situ Hybridization, Fluorescence; Indoles; Mice; Molecular Sequence Data; Mutation; Oncogene Proteins; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Staurosporine; Tissue Distribution | 1999 |
Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Kinetics; Lysophosphatidylcholines; Myocardium; Nimodipine; Phospholipases A; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Sulfonamides | 1999 |
Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alprostadil; Animals; Calcium; Cell Line; Cholera Toxin; Colchicine; Colforsin; Cyclic AMP; Cytochalasin B; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; GTP-Binding Proteins; Indoles; Isoenzymes; Isoproterenol; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1999 |
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid.
Topics: Animals; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Pyrans; Pyrethrins; Rats; Receptors, Adrenergic, alpha-1; Spiro Compounds; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
pp60v-src reactivation inhibits serum-induced accumulation of inositol phosphates and phosphatidylethanol in tsNRK.
Topics: Animals; Benzoquinones; Cell Line, Transformed; Culture Media; Enzyme Inhibitors; Genes, src; Glycerophospholipids; Indoles; Inositol Phosphates; Isoenzymes; Kidney; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phospholipase C gamma; Phosphotyrosine; Protein Kinase C; Quinones; Rats; Rifabutin; Staurosporine; Temperature; Type C Phospholipases | 1999 |
The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C.
Topics: Apoptosis; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Indoles; Maleimides; Molecular Structure; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Structure-Activity Relationship | 2000 |
Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin | 2000 |
Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
Topics: Bridged-Ring Compounds; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Naphthalenes; NF-kappaB-Inducing Kinase; Norbornanes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Thiocarbamates; Thiones; Tyrphostins | 2000 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils.
Topics: Adjuvants, Immunologic; Basophils; Calcium; Cell Survival; Complement C5a; DNA-Binding Proteins; Humans; Indoles; Interleukin-3; Interleukin-5; Intracellular Fluid; Janus Kinase 2; Leukotriene C4; MAP Kinase Signaling System; Milk Proteins; Nerve Growth Factor; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, IgE; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators | 2001 |
alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta.
Topics: Androstadienes; Animals; Calcium; Cells, Cultured; Chromones; COS Cells; Enzyme Inhibitors; Indoles; Inositol Phosphates; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Receptors, Transforming Growth Factor beta; Staurosporine; Transforming Growth Factor beta; Wortmannin | 2002 |
Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Indoles; Isoenzymes; Mice; Molecular Mimicry; Monosaccharide Transport Proteins; Muscle Proteins; Oligopeptides; Peptides; Protein Kinase C; Protein Kinase C beta; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents | 2003 |
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings.
Topics: Acetylcholine; Adenosine; Amphibians; Animals; Binomial Distribution; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Evoked Potentials; Indoles; Maleimides; Monte Carlo Method; Nerve Endings; Neuromuscular Junction; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rana pipiens; Staurosporine; Synaptic Vesicles | 2003 |
Protein kinase C (PKC) isotype profile in eosinophils from ponies with sweet itch and role in histamine-induced eosinophil activation.
Topics: Animals; Blotting, Western; Carbazoles; Dermatitis, Allergic Contact; Enzyme Inhibitors; Eosinophils; Histamine; Horse Diseases; Horses; Indoles; Isoenzymes; Lymphocyte Activation; Male; Protein Kinase C; Staurosporine; Superoxides | 2003 |
Modulation of histamine-induced Ca2+ release by protein kinase C. Effects on cytosolic and mitochondrial [Ca2+] peaks.
Topics: Aequorin; Calcium; Carbachol; Cytosol; Down-Regulation; Endoplasmic Reticulum; Enzyme Inhibitors; HeLa Cells; Histamine; Humans; Imidazoles; Indoles; Inositol 1,4,5-Trisphosphate; Maleimides; Mitochondria; Oscillometry; Protein Kinase C; Pyridines; Staurosporine; Time Factors; Transfection | 2003 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Carbazoles; Cell Membrane; Chlorocebus aethiops; COS Cells; Diglycerides; Estrenes; HeLa Cells; HL-60 Cells; Humans; Indoles; Maleimides; Membranes; Microscopy, Confocal; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Pyrrolidinones; Staurosporine | 2007 |
Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells.
Topics: Adenocarcinoma; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Fas-Associated Death Domain Protein; Humans; Indoles; Maleimides; Protein Kinase C; Staurosporine; TNF Receptor-Associated Death Domain Protein; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Differential inhibitor sensitivity between human kinases VRK1 and VRK2.
Topics: DNA Damage; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Staurosporine; Vaccinia virus | 2011 |