staurosporine has been researched along with rebeccamycin in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fabre, S; Prudhomme, M; Sancelme, M | 1 |
| Anizon, F; Aubertin, AM; Bailly, C; Fabbro, D; Meyer, T; Moreau, P; Ollier, M; Prudhomme, M; Riou, JF; Sancelme, M; Sevère, D; Voldoire, A | 1 |
| Braña, AF; Méndez, C; Rohr, J; Salas, AP; Salas, JA; Sánchez, C; Zhu, L | 1 |
| Asamizu, S; Furumai, T; Igarashi, Y; Onaka, H; Yoshida, R | 1 |
| Méndez, C; Salas, JA; Sánchez, C | 1 |
| Howard-Jones, AR; Walsh, CT | 2 |
| Bingman, CA; McCoy, JG; Phillips, GN; Singh, S; Thorson, JS; Zhang, C | 1 |
| Braña, AF; Carbajo, RJ; Méndez, C; Moris, F; Palomino, M; Pineda-Lucena, A; Salas, AP; Salas, JA; Sánchez, C | 1 |
| Chen, CY; Chen, YL; Chiu, HT; Jin, C; Lee, MN; Lin, YC | 1 |
| Onaka, H | 1 |
| Bhattacharya, A; Groom, K; Zechel, DL | 1 |
| Asamizu, S; Igarashi, Y; Nagano, S; Onaka, H; Shiro, Y | 1 |
2 review(s) available for staurosporine and rebeccamycin
| Article | Year |
|---|---|
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives.
Topics: Antibiotics, Antineoplastic; Carbazoles; Genes, Bacterial; Genetic Engineering; Indoles; Staurosporine | 2006 |
Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by actinomycetes.
Topics: Actinobacteria; Animals; Anti-Bacterial Agents; Carbazoles; Humans; Intercellular Signaling Peptides and Proteins; Peptides; Staurosporine | 2009 |
11 other study(ies) available for staurosporine and rebeccamycin
| Article | Year |
|---|---|
Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors.
Topics: Alkaloids; Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Calcimycin; Candida albicans; Carbazoles; Escherichia coli; Indole Alkaloids; Indoles; Microbial Sensitivity Tests; Mitosporic Fungi; Phosphorylation; Protein Kinase C; Staurosporine; Streptomyces; Streptomyces griseus | 1994 |
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Antineoplastic Agents; Carbazoles; Cell Line; Enzyme Inhibitors; Evaluation Studies as Topic; Humans; Indoles; Magnetic Resonance Spectroscopy; Protein Kinase C; Spectrophotometry, Infrared; Staurosporine; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1998 |
Combinatorial biosynthesis of antitumor indolocarbazole compounds.
Topics: Antineoplastic Agents; Carbazoles; Combinatorial Chemistry Techniques; Indoles; Staurosporine; Streptomyces | 2005 |
Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.
Topics: Amines; Amino Acid Sequence; Carbazoles; Cytochrome P-450 Enzyme System; Deoxy Sugars; Doxorubicin; Indoles; Models, Chemical; Models, Theoretical; Molecular Sequence Data; Mutation; Sequence Homology, Amino Acid; Staurosporine; Streptomyces | 2005 |
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid.
Topics: Carbazoles; Cloning, Molecular; Cytochrome P-450 Enzyme System; Escherichia coli; Flavin-Adenine Dinucleotide; Indoles; Kinetics; Mass Spectrometry; Mixed Function Oxygenases; NAD; Oxidation-Reduction; Oxygen Isotopes; Recombinant Proteins; Staurosporine; Streptomycetaceae | 2006 |
Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin.
Topics: Carbazoles; Cytochrome P-450 Enzyme System; Indoles; Molecular Structure; Oxidation-Reduction; Staurosporine | 2007 |
Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.
Topics: Carbazoles; Crystallization; Crystallography, X-Ray; Escherichia coli; Methyltransferases; Models, Molecular; Molecular Conformation; Protein Conformation; Recombinant Proteins; S-Adenosylhomocysteine; Staurosporine | 2008 |
Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles.
Topics: Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Cell Proliferation; Combinatorial Chemistry Techniques; Humans; Indole Alkaloids; Molecular Structure; Multigene Family; Plasmids; Protein Kinase Inhibitors; Staurosporine; Streptomyces | 2009 |
Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs.
Topics: Actinomycetales; Base Pairing; Carbazoles; Cloning, Molecular; Escherichia coli; Gene Library; Genome, Bacterial; Indole Alkaloids; Indoles; Molecular Sequence Data; Multigene Family; Sequence Analysis, DNA; Staurosporine | 2009 |
Rebeccamycin and staurosporine biosynthesis: insight into the mechanisms of the flavin-dependent monooxygenases RebC and StaC.
Topics: Amino Acid Sequence; Biocatalysis; Carbazoles; Catalytic Domain; Mixed Function Oxygenases; Molecular Sequence Data; Staurosporine | 2011 |
Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis.
Topics: Amino Acid Sequence; Binding Sites; Carbazoles; Cloning, Molecular; Flavin-Adenine Dinucleotide; Indole Alkaloids; Indoles; Molecular Sequence Data; Molecular Structure; Oxidation-Reduction; Oxygenases; Pyrroles; Staurosporine; Streptomyces; Substrate Specificity | 2011 |